Search

Your search keyword '"Cui, Chaoyu"' showing total 103 results
Start Over Author "Cui, Chaoyu"
103 results on '"Cui, Chaoyu"'

6. A Novel Reconfigurable Compliant Mechanism with Adjustable Motion Direction and Multiple Motion Modes

Author

Du, Junjie, Zhang, Xianmin, Zhu, Benliang, Xu, Hao, Cui, Chaoyu, Huang, Yanjiang, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Okada, Masafumi, editor

Published
2023
Full Text
View/download PDF

7. Genetic-Algorithm-Based Pose Design for Soft Magnetic Origami Robots

Author

Cui, Chaoyu, Zhu, Benliang, Lin, Rongzhou, Du, Junjie, Zhang, Xianmin, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Okada, Masafumi, editor

Published
2023
Full Text
View/download PDF

8. Origami-Based Rotating Bistable Mechanism

Author

Wu, Zhenfeng, Li, Jierong, Cui, Chaoyu, Yang, Lixin, Zhang, Xianmin, Zhu, Benliang, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Okada, Masafumi, editor

Published
2023
Full Text
View/download PDF

13. The mntHgene of Burkholderia cenocepaciainfluences motility and quorum sensing to control virulence

Author

Yang, Chunxi, Cui, Chaoyu, and Deng, Fengyi

Abstract

Quorum sensing (QS) signals widely exist in bacteria to control biological functions in response to populations of cells. Burkholderia cenocepacia, an important opportunistic pathogen in patients with cystic fibrosis (CF), is commonly found in the environment and mostly utilizes the N-acylhomoserine lactone (AHL) and cis-2-dodecenoic acid (BDSF) QS systems to control biological functions. Our previous study illuminated the detailed mechanism by which B.cenocepaciaintegrates BDSF and cyclic diguanosine monophosphate (c-di-GMP) signals to control virulence. Here, we employed Tn5 transposon mutagenesis to identify genes related to the BDSF QS system. One of the most significantly attenuated mutants had an insertion in the mntHgene. Here, we showed that MntH (Bcam0836), a manganese transport protein, controls QS-regulated phenotypes, including motility, biofilm formation and virulence. We also found that. BDSF production was attenuated at both the gene and signaling levels in the Bcam0836 mutant, and that Bcam0836 influenced the expression of some genes regulated by the BDSF receptor RpfR and the downstream regulator GtrR. These results show that the manganese transport protein. MntH modulates a subset of genes and functions regulated by the QS system in B. cenocepacia.

Published
2024
Full Text
View/download PDF

16. DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response

Author

Jiao, Huipeng, primary, James, Sharmy J., additional, Png, Chin Wen, additional, Cui, Chaoyu, additional, Li, Heng, additional, Li, Liang, additional, Chia, Wan Ni, additional, Min, Nyo, additional, Li, Weiyun, additional, Claser, Carla, additional, Rénia, Laurent, additional, Wang, Hongyan, additional, Chen, Mark I-Cheng, additional, Chu, Justin Jang Hann, additional, Tan, Kevin Shyong Wei, additional, Deng, Yinyue, additional, and Zhang, Yongliang, additional

Published
2024
Full Text
View/download PDF

29. Cassini Oval Scanning for High-Speed AFM Imaging

Author

Liao, Yu, primary, Zhang, Xianmin, additional, Yu, Longhuan, additional, Lai, Jianhao, additional, Zhu, Benliang, additional, Li, Hai, additional, Yang, Zhuobo, additional, Cui, Chaoyu, additional, and Feng, Ke, additional

Published
2022
Full Text
View/download PDF

31. A Novel Harmonic Atomic Force Microscopy With Tip-Sample Couplings

Author

Feng, Ke, Lai, Jianhao, Gao, Jiarui, Cui, Chaoyu, Zhu, Benliang, and Zhang, Xianmin

Abstract

This article presents a novel harmonic atomic force microscopy with tip-sample couplings (TS-HAFM) working in force modulation mode for imaging samples of different mechanical properties. Compared with traditional harmonic atomic force microscopy (T-HAFM), TS-HAFM has better harmonic characteristics and imaging resolution. T-HAFM does not consider the effect of tip-sample couplings on probe vibration; it can only generate harmonics in the free vibration state. However, after the tip touches the sample, the tip-sample coupling shifts the probe frequency and attenuates the probe's harmonic characteristics. TS-HAFM considers the effect of tip-sample couplings on probe vibration and can prevent problems of image resolution reduction and vibration stability degradation caused by harmonic attenuation. We first tested the Young's modulus of the sample and calculated the tip-sample contact's equivalent contact stiffness based on the Johnson–Kendall–Roberts model. The harmonic probe with tip-sample couplings and the traditional harmonic probe were subsequently designed. Then, the two probes were applied to the topography detection of polypropylene spheres covered with PDMS film and cells on PDMS substrates. Experimental results showed that TS-HAFM was up to 2.01 times more sensitive than T-HAFM in detecting samples of different mechanical properties. When detecting soft samples on PDMS substrates, TS-HAFM still has higher imaging clarity. TS-HAFM has emerged as a powerful platform for high resolution imaging of samples with different mechanical properties, while improving resistance to system interference.

Published
2024
Full Text
View/download PDF

39. Disruption of Quorum Sensing and Virulence in Burkholderia cenocepacia by a Structural Analogue of the cis-2-Dodecenoic Acid Signal

Author

Cui Chaoyu, Sun Xiuyun, Yang Chunxi, Kang Li, Shihao Song, Yutong Huang, Yinyue Deng, Shuo Zhao, and Yongliang Zhang

Subjects
Burkholderia cenocepacia, Homoserine, Virulence, Microbial Sensitivity Tests, Acyl-Butyrolactones, Applied Microbiology and Biotechnology, Microbiology, Fatty Acids, Monounsaturated, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Pathogen, Cyclic GMP, Unsaturated fatty acid, 030304 developmental biology, Antibacterial agent, 0303 health sciences, Ecology, biology, 030306 microbiology, Public and Environmental Health Microbiology, Biofilm, food and beverages, Quorum Sensing, Burkholderia Infections, Gene Expression Regulation, Bacterial, biology.organism_classification, Quorum sensing, Phenotype, chemistry, Biofilms, Food Science, Biotechnology, Signal Transduction
Abstract

Quorum sensing (QS) signals are widely used by bacterial pathogens to control biological functions and virulence in response to changes in cell population densities. Burkholderia cenocepacia employs a molecular mechanism in which the cis -2-dodecenoic acid (named B urkholderia d iffusible s ignal f actor, abbreviated as BDSF) QS system regulates N -acyl homoserine lactone (AHL) signal production and virulence by modulating intracellular levels of cyclic diguanosine monophosphate (c-di-GMP). Thus, inhibition of BDSF signaling may offer a non-antibiotic-based therapeutic strategy against BDSF-regulated bacterial infections. In this study, we report the synthesis of small molecule mimics of the BDSF signal and evaluate their ability to inhibit BDSF QS signaling in B. cenocepacia . A novel structural analogue of BDSF, 14-Me-C16:Δ 2 ( cis -14-methylpentadec-2-enoic acid), was observed to inhibit BDSF production and impair BDSF-regulated phenotypes in B. cenocepacia , including motility, biofilm formation and virulence, while it did not inhibit the growth rate of this pathogen. 14-Me-C16:Δ 2 also reduced AHL signal production. Genetic and biochemical analyses showed that 14-Me-C16:Δ 2 inhibited the production of the BDSF and AHL signals by decreasing the expression of their synthase-encoding genes. Notably, 14-Me-C16:Δ 2 attenuated BDSF-regulated phenotypes in various Burkholderia species. These findings suggest that 14-Me-C16:Δ 2 could potentially be developed as a new therapeutic agent against pathogenic Burkholderia species by interfering with their QS signaling. IMPORTANCE Burkholderia cenocepacia is an important opportunistic pathogen which can cause life-threatening infections in susceptible individuals, particularly in cystic fibrosis and immunocompromised patients. It usually employs two type quorum sensing (QS) systems, including the cis -2-dodecenoic acid (BDSF) system and N -acyl homoserine lactone (AHL) system, to regulate virulence. In this study, we have designed and identified an unsaturated fatty acid compound ( cis -14-methylpentadec-2-enoic acid, named as 14-Me-C16:Δ 2 ) that is capable of interfering with B. cenocepacia QS signaling and virulence. We demonstrate that 14-Me-C16:Δ 2 reduced BDSF and AHL signal production in B. cenocepacia . It also impaired QS-regulated phenotypes in various Burkholderia species. These results suggest that 14-Me-C16:Δ 2 could interfere with QS signaling in many Burkholderia species and might be developed as a new antibacterial agent.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results