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BackgroundIt is still controversial whether or not serum uric acid, a key risk for coronary heart disease, is significantly associated with prognosis of acute myocardial infarction (AMI) . And there are rare large-scale and multicenter studies on serum uric acid and long prognosis of AMI in China.ObjectiveTo investigate the relationship between serum uric acid and long-term prognosis in AMI patients.MethodsOne thousand and ninety-eight AMI patients from 9 hospitals (Chengdu First People's Hospital, Chengdu Second People's Hospital, the Third People's Hospital of Chengdu, the First Affiliated Hospital of Chengdu Medical College, Dujiangyan Medical Center, Pidu District People's Hospital, Chengdu, Shuangliu District First People's Hospital, Jintang First People's Hospital, the People's Hospital of Pengzhou) in Chengdu during September 2016 to July 2019 were consecutively reSScruited. Baseline data were collected via the electronic medical record system of each hospital by trained professionals, including: (1) demographic data: age, gender, prevalence of smoking; (2) clinical complications and related information: hypertension, diabetes, blood pressure, heart rate, Killip class, AMI type (NSTEMI or STEMI) , prevalence of percutaneous coronary intervention (PCI) ; (3) laboratory parameters: serum SScreatinine (Scr) , uric acid (UA) , triglyceride (TG) , total cholesterol (TC) , low-density lipoprotein cholesterol (LDL-C) , high-density lipoprotein cholesterol (HDL-C) , estimated glomerular filtration rate (eGFR) ; (4) post-discharge medication: aspirin, clopidogrel/tigrelol, statins, Beta-blockers, ACEI/ARB, diuretics. Baseline data were compared between patients with and without major adverse cardiovascular and cerebrovascular events (MACCE) during post-discharge follow-up. Then, prognosis was compared aSScross UA tertile subgroups〔A: UA

Capture and catalytic conversion of CO2 into value‐added chemicals is a promising and sustainable approach to relieve global warming and the energy crisis. Nitrogen‐rich porous organic polymers (POPs) are promising materials for CO2 capture and separation, but their application in the additive‐free catalytic conversion of CO2 into cyclic carbonates is still a challenge. Herein, a nitrogen‐rich click‐based POP (CPP) was developed for the cycloaddition reaction of CO2 with epoxides in the absence of metal, solvents, and additives. The introduction of imidazolium‐based ionic liquids on the CPP host backbone could modulate the porosity, CO2 adsorption/desorption, CO2 selectivity over N2, and catalytic activity in the chemical transformation. A tentative catalytic pathway was proposed to account for the superior catalytic activity of the catalytic systems, in which the incorporated ionic liquid and porous properties of CPP synergistically contributed to the catalytic reaction. This study provides a platform to understand the cooperative effects of porous properties and nucleophilic anions on the cycloaddition reaction of CO2 with epoxides. [ABSTRACT FROM AUTHOR]

Abstract: Formic acid (FA) is one of the most favorable chemical hydrogen storage materials for renewable energy transformation, the development of efficient heterogeneous catalysts for ultraclean H2 generation from FA in the absence of any alkalis or additives under mild conditions remains a major challenge. Here, we present a porous organic polymer containing triphenylamine (TPA) and 2,6‐bis(1,2,3‐triazol‐4‐yl)pyridyl (BTP) units (TB‐POP). The ultrafine palladium nanoparticles (NPs) with an average size of 1.5±0.6 nm can be facilely generated using convenient methods and are uniformly dispersed over the TB‐POP support. TPA and BTP units are homogeneously arranged in the host framework of TB‐POP; they serve as effective alternatives of basic sites to deprotonate FA into formate intermediates. Pd@TB‐POP has demonstrated remarkable catalytic activity and high selectivity in additive‐free dehydrogenation of aqueous FA solution. The value of initial turnover frequency (TOF) at 50 °C is as high as 1344 h−1. In sharp contrast, the use of sodium formate as an additive in the catalytic system results in the decrement of catalytic activity. The ultrafine palladium NPs are effectively immobilized during dehydrogenation of FA, and no aggregation of palladium NPs is observed after consecutive catalytic runs. [ABSTRACT FROM AUTHOR]

Abstract: In the presence of aromatic carboxylic acids, three new d10 transition metal coordination polymers, [Ag(PAHT)] n (1), [Ag2(HCA)] n (2) and [Cu6(CA)2(H2O)] n (3) (HPAHT=2-phenyl-4-amino-6-hydroxy-1,3,5-triazine, H3CA=cyanuric acid) have been synthesized based on in-situ 1,3,5-triazine derivatives resulting from 2,4-diamino-6-phenyl-1,3,5-triazine, 2-chloro-4,6-diamino-1,3,5-triazine and melamine under hydrothermal conditions. Complexes 1–3 have been characterized by single-crystal X-ray diffraction, IR spectra, elemental analysis and thermogravimetric analysis (TGA). The compound 1 exhibits a uninodal three-connected 3D network with a rare lig LiGe type topology, which contains right-handed and left-handed [Ag(PAHT)] n helical chains. For compound 2, the 3D network is comprised of 2D sheet by strongly Ag–O and weakly Ag(I)…Ag(I) interactions. In compound 3, it is infrequently observed that dodecanuclear copper(I) units as secondary building units (SBUs) construct 3D network by the ligands CA3− with a rare uninodal 10-connected bct topology (312.428.55). The photoluminescent properties of three compounds have also been measured. [Copyright &y& Elsevier]

Objective: To assess the age-related differences in the management strategies and outcomes of patients with acute coronary syndrome (ACS) under the chest pain center model., Methods: Clinical data of 2 833 patients with ACS were enrolled in the retrospective observational registry between January 2017 and June 2019 at 11 hospitals with chest pain centers in Chengdu. The patients were divided into four groups according to their ages: < 55 years old group (n = 569), 55-64 years old group (n = 556), 65-74 years old group (n = 804), ≥ 75 years old group (n = 904). The collected data included the patients' demographic characteristics, cardiovascular risk factors, medical history, symptoms and signs of onset, experimental examination, types of ACS and the time from the symptom to the hospital (S-to-D), etc., and the clinical characteristics, management strategies, all-cause mortality in the hospital, and the incidence of major adverse cardiovascular and cerebrovascular events (MACCE) within 1 year after discharge were compared. The primary end point was the clinical outcome of ACS patients in different age groups, including all-cause deaths in the hospital and the incidence of MACCE within 1 year after discharge. The secondary end point was the proportion of ACS patients underwent percutaneous coronary intervention (PCI) in different age groups. Multivariate Logistic regression was used to analyze the risk factors of all-cause deaths in ACS patients. Kaplan-Meier curve was used to express the incidence of MACCE within 1 year after discharge in different age groups. Multivariate Cox regression was used to analyze the factors affecting the incidence of MACCE within 1 year after discharge of ACS patients., Results: As age increased, the proportion of male patients gradually decreased, and the percentages of male patients aged < 55 years old, 55-64 years old, 65-74 years old, and ≥ 75 years old were 87.2% (496/569), 77.0% (428/556), 66.4% (534/804), and 60.1% (543/904), respectively; and ACS patients combined with hypertension, diabetes, coronary heart disease, and stroke history were more common [the percentages of patients with hypertension aged < 55 years old, 55-64 years old, 65-74 years old, ≥ 75 years old were 41.3% (235/569), 52.2% (290/556), 59.7% (480/804), and 66.9% (605/904); the percentages of diabetes were 18.6% (106/569), 25.5% (142/556), 27.0% (217/804), and 28.2% (255/904); the percentages of coronary heart disease were 10.1% (57/564), 13.9% (77/555), 17.6% (141/803), and 23.7% (213/899); the percentages of stroke were 0.7% (4/564), 4.0% (22/552), 4.5% (36/801), and 8.6% (77/894)]. But the percentages of patients with a history of active smoking, typical chest pain/chest tightness and dyslipidemia were significantly reduced [the percentages of smoking history were 60.2% (340/565), 48.0% (266/554), 33.7% (270/801), and 21.7% (195/899), typical chest pain/chest tightness were 96.9% (536/553), 96.4% (516/535), 91.8% (716/780), 90.2% (776/860); the percentages of dyslipidemia were 11.2% (63/565), 9.2% (51/553), 5.7% (46/802), and 4.9% (44/896)], the time of S-to-D was significantly prolonged [minutes: 176.0 (73.5, 557.0), 194.5 (89.3, 682.3), 221.0 (98.8, 940.5), and 270.0 (115.0, 867.0)], hemoglobin (Hb) level was significantly reduced (g/L: 145.44±17.43, 135.95±19.25, 129.75±19.03, 122.19±20.55), and the incidence of non-ST-segment elevation myocardial infarction (NSTEMI) increased significantly [18.6% (106/569), 20.5% (114/556), 26.6% (214/804), 26.5% (240/904)], and the differences were statistically significant (all P < 0.05). The proportion of Killip grade III-IV were the highest in patients aged ≥ 75 years old, 9.0% and 12.6%, respectively. Compared with the groups aged < 55 years old, 55-64 years old, and 65-74 years old, the proportion of patients aged ≥ 75 years old who underwent PCI was the lowest, and the all-cause mortality in the hospital and the incidence of 1-year MACCE of patients underwent PCI were significantly lower than those of patients underwent conservative treatment [6.0% (28/463) vs. 10.4% (45/434), 14.6% (43/294) vs. 24.3 % (55/226), both P < 0.05]. As age increased, the hospital all-cause mortality and the 1-year MACCE incidence increased (all-cause mortality rates in < 55 years old, 55-64 years old, 65-74 years old, ≥ 75 years old groups were 0.9%, 2.2%, 5.5%, 8.3%, and the 1-year MACCE incidences were 5.0%, 6.7%, 13.9%, 18.7%, both P < 0.01). The multivariate Logistic regression analysis showed that age, cardiogenic shock, ST-segment elevation myocardial infarction (STEMI), the number of vascular disease and underwent PCI were the independent risk factors of all-cause mortality [the odds ratio (OR) and 95% confidence interval (95%CI) were 1.644 (1.356-1.993), 11.794 (7.469-18.621), 2.449 (1.419-4.227), 1.334 (1.096-1.624), 0.391 (0.247-0.619), all P < 0.001]. Cox regression analysis showed that age, STEMI, the number of vascular disease and underwent PCI were independent risk factors of the occurrence of MACCE within 1 year after discharge [hazard ratio (HR) and 95%CI were 1.354 (1.205-1.521), 1.387 (1.003-1.916), 1.314 (1.155-1.495), 0.547 (0.402-0.745), all P < 0.05]., Conclusions: In the chest pain center model, compared with other age of ACS patients, the proportion of NSTEMI in elderly patients group aged ≥ 75 years old was higher, the proportion of PCI was lower, and the clinical outcome was worse. However, the prognosis of elderly patients receiving PCI treatment was better than the patients receiving conservative treatment.

Capture and catalytic conversion of CO 2 into value-added chemicals is a promising and sustainable approach to relieve global warming and the energy crisis. Nitrogen-rich porous organic polymers (POPs) are promising materials for CO 2 capture and separation, but their application in the additive-free catalytic conversion of CO 2 into cyclic carbonates is still a challenge. Herein, a nitrogen-rich click-based POP (CPP) was developed for the cycloaddition reaction of CO 2 with epoxides in the absence of metal, solvents, and additives. The introduction of imidazolium-based ionic liquids on the CPP host backbone could modulate the porosity, CO 2 adsorption/desorption, CO 2 selectivity over N 2 , and catalytic activity in the chemical transformation. A tentative catalytic pathway was proposed to account for the superior catalytic activity of the catalytic systems, in which the incorporated ionic liquid and porous properties of CPP synergistically contributed to the catalytic reaction. This study provides a platform to understand the cooperative effects of porous properties and nucleophilic anions on the cycloaddition reaction of CO 2 with epoxides., (© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

The synthesis of five-membered cyclic carbonates via catalytic cycloaddition reaction of CO 2 with epoxides is considered to be an effective technology for alleviation of the energy crisis and global warming. Various commercial organic bases and ionic salts were used as catalysts, while the relationship of catalytic activity and compound structure has been seldom explored. Herein, a facilely obtained binary catalytic system based on triethylamine/NBu 4 Br was developed for CO 2 activation and chemical fixation. The highly efficient catalytic system showed outstanding conversion and above 99% selectivity under metal-free mild reaction conditions (100 °C, 1 atm) in one hour. The detailed process of CO 2 activation and chemical fixation was investigated at the molecular level by a series of experiments and theoretical calculation, which provided a mode for the design and synthesis of a highly efficient catalytic system for conversion of CO 2 under mild conditions., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)