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2. The Role of Oligomeric Gold-Thiolate Units in Single Molecule Junc-tions of Thiol-Anchored Molecules

Author

Leary, Edmund, Zotti, Linda A., Miguel, Delia, Márquez, Irene R., Palomino-Ruiz, Lucía, Cuerva, Juan Manuel, Rubio-Bollinger, Gabino, González, M. Teresa, and Agrait, Nicolás

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

Using the break junction (BJ) technique we show that Au(RS)2 units play a significant role in thiol-terminated molecular junctions formed on gold. We have studied a range of thiol-terminated compounds, either with the sulfur atoms in direct conjugation with a phenyl core, or bonded to saturated methylene groups. For all molecules we observe at least two distinct groups of conductance plateaus. By a careful analysis of the length behavior of these plateaus, comparing the behavior across the different cores and with methyl sulfide anchor groups, we demonstrate that the lower conductance groups correspond to the incorporation of Au(RS)2 oligomeric units at the contacts. These structural motifs are found on the surface of gold nanoparticles but they have not before been shown to exist in molecular-break junctions. The results, while exemplifying the complex nature of thiol chemistry on gold, moreover clarify the conductance of 1,4-benzenedithiol on gold. We show that true Au-S-Ph-S-Au junctions have a relatively narrow conductance distribution., Comment: 9 pages, 7 figures

Published
2018
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3. Chirality-induced spin selectivity in functionalized carbon nanotube networks: The role of spin–orbit coupling.

Author

Firouzeh, Seyedamin, Illescas-Lopez, Sara, Hossain, Md Anik, Cuerva, Juan Manuel, Álvarez de Cienfuegos, Luis, and Pramanik, Sandipan

Subjects
SPIN-orbit interactions, CARBON nanotubes, CHIRALITY
Abstract

Spin–orbit coupling in a chiral medium is generally assumed to be a necessary ingredient for the observation of the chirality-induced spin selectivity (CISS) effect. However, some recent studies have suggested that CISS may manifest even when the chiral medium has zero spin–orbit coupling. In such systems, CISS may arise due to an orbital polarization effect, which generates an electromagnetochiral anisotropy in two-terminal conductance. Here, we examine these concepts using a chirally functionalized carbon nanotube network as the chiral medium. A transverse measurement geometry is used, which nullifies any electromagnetochiral contribution but still exhibits the tell-tale signs of the CISS effect. This suggests that CISS may not be explained solely by electromagnetochiral effects. The role of nanotube spin–orbit coupling on the observed pure CISS signal is studied by systematically varying nanotube diameter. We find that the magnitude of the CISS signal scales proportionately with the spin–orbit coupling strength of the nanotubes. We also find that nanotube diameter dictates the supramolecular chirality of the medium, which in turn determines the sign of the CISS signal. [ABSTRACT FROM AUTHOR]

Published
2023
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4. CD1 and iNKT cells mediate immune responses against the GBS hemolytic lipid toxin induced by a non-toxic analog

Author

Furuta, Anna, primary, Coleman, Michelle, additional, Casares, Raquel, additional, Seepersaud, Ravin, additional, Orvis, Austyn, additional, Brokaw, Alyssa, additional, Quach, Phoenicia, additional, Nguyen, Shayla, additional, Sweeney, Erin, additional, Sharma, Kavita, additional, Wallen, Grace, additional, Sanghavi, Rhea, additional, Mateos-Gil, Jaime, additional, Cuerva, Juan Manuel, additional, Millán, Alba, additional, and Rajagopal, Lakshmi, additional

Published
2023
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5. Cell Survival Enabled by Leakage of a Labile Metabolic Intermediate

Author

Medina-Carmona, Encarnacion, Gutierrez-Rus, Luis I, Manssour-Triedo, Fadia, Newton, Matilda S, Gamiz-Arco, Gloria, Mota, Antonio J, Reiné, Pablo, Cuerva, Juan Manuel, Ortega-Muñoz, Mariano, Andrés-León, Eduardo, Ortega-Roldan, Jose Luis, Seelig, Burckhard, Ibarra-Molero, Beatriz, Sanchez-Ruiz, Jose M, Medina-Carmona, Encarnacion, Gutierrez-Rus, Luis I, Manssour-Triedo, Fadia, Newton, Matilda S, Gamiz-Arco, Gloria, Mota, Antonio J, Reiné, Pablo, Cuerva, Juan Manuel, Ortega-Muñoz, Mariano, Andrés-León, Eduardo, Ortega-Roldan, Jose Luis, Seelig, Burckhard, Ibarra-Molero, Beatriz, and Sanchez-Ruiz, Jose M

Abstract

Many metabolites are generated in one step of a biochemical pathway and consumed in a subsequent step. Such metabolic intermediates are often reactive molecules which, if allowed to freely diffuse in the intracellular milieu, could lead to undesirable side reactions and even become toxic to the cell. Therefore, metabolic intermediates are often protected as protein-bound species and directly transferred between enzyme active sites in multi-functional enzymes, multi-enzyme complexes and metabolons. Sequestration of reactive metabolic intermediates thus contributes to metabolic efficiency. It is not known, however, whether this evolutionary adaptation can be relaxed in response to challenges to organismal survival. Here, we report evolutionary repair experiments on E. coli cells in which an enzyme crucial for the biosynthesis of proline has been deleted. The deletion makes cells unable to grow in a culture medium lacking proline. Remarkably, however, cell growth is efficiently restored by many single mutations (12 at least) in the gene of glutamine synthetase. The mutations cause the leakage to the intracellular milieu of a highly reactive phosphorylated intermediate common to the biosynthetic pathways of glutamine and proline. This intermediate is generally assumed to exist only as a protein-bound species. Nevertheless, its diffusion upon mutation-induced leakage enables a new route to proline biosynthesis. Our results support that leakage of sequestered metabolic intermediates can readily occur and contribute to organismal adaptation in some scenarios. Enhanced availability of reactive molecules may enable the generation of new biochemical pathways and the potential of mutation-induced leakage in metabolic engineering is noted.

Published
2023

6. Cell Survival Enabled by Leakage of a Labile Metabolic Intermediate

Author

Human Frontier Science Program, Ministerio de Ciencia e Innovación (España), European Commission, National Aeronautics and Space Administration (US), Junta de Andalucía, Medina-Carmona, E., Gutierrez-Rus, Luis I., Manssour-Triedo, Fadia, Newton, Matilda S., Gamiz-Arco, Gloria, Mota, A. J., Reiné, Pablo, Cuerva, Juan Manuel, Ortega-Muñoz, Mariano, Andrés-León, Eduardo, Ortega-Roldan, Jose Luis, Seelig, Burckhard, Ibarra-Molero, Beatriz, Sánchez-Ruiz, J.M., Human Frontier Science Program, Ministerio de Ciencia e Innovación (España), European Commission, National Aeronautics and Space Administration (US), Junta de Andalucía, Medina-Carmona, E., Gutierrez-Rus, Luis I., Manssour-Triedo, Fadia, Newton, Matilda S., Gamiz-Arco, Gloria, Mota, A. J., Reiné, Pablo, Cuerva, Juan Manuel, Ortega-Muñoz, Mariano, Andrés-León, Eduardo, Ortega-Roldan, Jose Luis, Seelig, Burckhard, Ibarra-Molero, Beatriz, and Sánchez-Ruiz, J.M.

Abstract

Many metabolites are generated in one step of a biochemical pathway and consumed in a subsequent step. Such metabolic intermediates are often reactive molecules which, if allowed to freely diffuse in the intracellular milieu, could lead to undesirable side reactions and even become toxic to the cell. Therefore, metabolic intermediates are often protected as protein-bound species and directly transferred between enzyme active sites in multi-functional enzymes, multi-enzyme complexes, and metabolons. Sequestration of reactive metabolic intermediates thus contributes to metabolic efficiency. It is not known, however, whether this evolutionary adaptation can be relaxed in response to challenges to organismal survival. Here, we report evolutionary repair experiments on Escherichia coli cells in which an enzyme crucial for the biosynthesis of proline has been deleted. The deletion makes cells unable to grow in a culture medium lacking proline. Remarkably, however, cell growth is efficiently restored by many single mutations (12 at least) in the gene of glutamine synthetase. The mutations cause the leakage to the intracellular milieu of a highly reactive phosphorylated intermediate common to the biosynthetic pathways of glutamine and proline. This intermediate is generally assumed to exist only as a protein-bound species. Nevertheless, its diffusion upon mutation-induced leakage enables a new route to proline biosynthesis. Our results support that leakage of sequestered metabolic intermediates can readily occur and contribute to organismal adaptation in some scenarios. Enhanced availability of reactive molecules may enable the generation of new biochemical pathways and the potential of mutation-induced leakage in metabolic engineering is noted.

Published
2023

8. Cell Survival Enabled by Leakage of a Labile Metabolic Intermediate

Author

Medina-Carmona, Encarnación, primary, Gutierrez-Rus, Luis I, additional, Manssour-Triedo, Fadia, additional, Newton, Matilda S, additional, Gamiz-Arco, Gloria, additional, Mota, Antonio J, additional, Reiné, Pablo, additional, Cuerva, Juan Manuel, additional, Ortega-Muñoz, Mariano, additional, Andrés-León, Eduardo, additional, Ortega-Roldan, Jose Luis, additional, Seelig, Burckhard, additional, Ibarra-Molero, Beatriz, additional, and Sanchez-Ruiz, Jose M, additional

Published
2023
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10. 2D self-assembly of o-OPE foldamers for chiroptical barcoding

Author

López-Sicilia, Irene, primary, Ortuño, Ana, additional, Reiné, Pablo, additional, Otero, Dario, additional, Martin-Romero, Maria Teresa, additional, Camacho, Luis, additional, Alvarez de Cienfuegos, Luis, additional, Orte, Angel, additional, Giner-Casares, Juan J, additional, Miguel, Delia, additional, and Cuerva, Juan Manuel, additional

Published
2023
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12. Cell survival enabled by leakage of a labile metabolic intermediate

Author

Medina-Carmona, Encarnación, primary, Gutierrez-Rus, Luis I., additional, Manssour-Triedo, Fadia, additional, Newton, Matilda S., additional, Gamiz-Arco, Gloria, additional, Mota, Antonio J., additional, Reiné, Pablo, additional, Cuerva, Juan Manuel, additional, Ortega-Muñoz, Mariano, additional, Andrés-León, Eduardo, additional, Ortega-Roldan, Jose Luis, additional, Seelig, Burckhard, additional, Ibarra-Molero, Beatriz, additional, and Sanchez-Ruiz, Jose M., additional

Published
2022
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14. Heme-binding enables allosteric modulationin an ancient TIM-barrel glycosidase

Author

Ministerio de Economía y Competitividad (España), Gamiz-Arco, Gloria, Gutierrez-Rus, Luis I., Risso, Valeria A., Ibarra-Molero, Beatriz, Hoshino, Yosuke, Petrović, Dušan, Justicia, Jose, Cuerva, Juan Manuel, Romero-Rivera, Adrian, Seelig, Burckhard, Gavira Gallardo, J. A., Kamerlin, Shina C.L., Gaucher, Eric A., Sánchez-Ruiz, Jose M., Ministerio de Economía y Competitividad (España), Gamiz-Arco, Gloria, Gutierrez-Rus, Luis I., Risso, Valeria A., Ibarra-Molero, Beatriz, Hoshino, Yosuke, Petrović, Dušan, Justicia, Jose, Cuerva, Juan Manuel, Romero-Rivera, Adrian, Seelig, Burckhard, Gavira Gallardo, J. A., Kamerlin, Shina C.L., Gaucher, Eric A., and Sánchez-Ruiz, Jose M.

Abstract

Glycosidases are phylogenetically widely distributed enzymes that are crucial for the cleavage of glycosidic bonds. Here, we present the exceptional properties of a putative ancestor of bacterial and eukaryotic family-1 glycosidases. The ancestral protein shares the TIM-barrel fold with its modern descendants but displays large regions with greatly enhanced conformational flexibility. Yet, the barrel core remains comparatively rigid and the ancestral glycosidase activity is stable, with an optimum temperature within the experimental range for thermophilic family-1 glycosidases. None of the ∼5500 reported crystallographic structures of ∼1400 modern glycosidases show a bound porphyrin. Remarkably, the ancestral glycosidase binds heme tightly and stoichiometrically at a well-defined buried site. Heme binding rigidifies this TIM-barrel and allosterically enhances catalysis. Our work demonstrates the capability of ancestral protein reconstructions to reveal valuable but unexpected biomolecular features when sampling distant sequence space. The potential of the ancestral glycosidase as a scaffold for custom catalysis and biosensor engineering is discussed.

Published
2021

15. Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase

Author

Gamiz-Arco, Gloria, primary, Gutierrez-Rus, Luis I., additional, Risso, Valeria A., additional, Ibarra-Molero, Beatriz, additional, Hoshino, Yosuke, additional, Petrović, Dušan, additional, Justicia, Jose, additional, Cuerva, Juan Manuel, additional, Romero-Rivera, Adrian, additional, Seelig, Burckhard, additional, Gavira, Jose A., additional, Kamerlin, Shina C. L., additional, Gaucher, Eric A., additional, and Sanchez-Ruiz, Jose M., additional

Published
2021
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17. Extended enantiopure ortho-phenylene ethylene (o-OPE)-based helical systems as scaffolds for supramolecular architectures: a study of chiroptical response and its connection to the CISS effect

Author

Ortuño, Ana M., primary, Reiné, Pablo, additional, Resa, Sandra, additional, Álvarez de Cienfuegos, Luis, additional, Blanco, Victor, additional, Paredes, José Manuel, additional, Mota, Antonio J., additional, Mazzeo, Giuseppe, additional, Abbate, Sergio, additional, Ugalde, Jesus M., additional, Mujica, Vladimiro, additional, Longhi, Giovanna, additional, Miguel, Delia, additional, and Cuerva, Juan Manuel, additional

Published
2021
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20. Lipid analogs reveal features critical for hemolysis and diminish granadaene mediated Group B Streptococcus infection

Author

Armistead, Blair, primary, Herrero-Foncubierta, Pilar, additional, Coleman, Michelle, additional, Quach, Phoenicia, additional, Whidbey, Christopher, additional, Justicia, Jose, additional, Tapia, Ruben, additional, Casares, Raquel, additional, Millán, Alba, additional, Haidour, Ali, additional, Granger, Javier Rodriguez, additional, Vornhagen, Jay, additional, Santana-Ufret, Verónica, additional, Merillat, Sean, additional, Adams Waldorf, Kristina, additional, Cuerva, Juan Manuel, additional, and Rajagopal, Lakshmi, additional

Published
2020
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21. Corrigendum: The cyl Genes Reveal the Biosynthetic and Evolutionary Origins of the Group B Streptococcus Hemolytic Lipid, Granadaene

Author

Armistead, Blair, primary, Whidbey, Christopher, additional, Iyer, Lakshminarayan M., additional, Herrero-Foncubierta, Pilar, additional, Quach, Phoenicia, additional, Haidour, Ali, additional, Aravind, L., additional, Cuerva, Juan Manuel, additional, Jaspan, Heather B., additional, and Rajagopal, Lakshmi, additional

Published
2020
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27. Granadaene: Proposed structure of the group B Streptococcus polyenic pigment

Author

Rosa-Fraile, Manuel, Rodriguez-Granger, Javier, Haidour-Benamin, Ali, Cuerva, Juan Manuel, and Sampedro, Antonio

Subjects
Streptococcus agalactiae -- Structure, Streptococcus agalactiae -- Genetic aspects, Nuclear magnetic resonance spectroscopy -- Usage, Biological sciences
Abstract

The chemical nature of the red pigment produced by the group B streptococcus (GBS) Streptococcus agalactiae, earlier thought to be a carotene, is investigated. Elemental analysis and mass and nuclear magnetic resonance spectral studies result in a proposal of the structure to be a 676-Da ornithine rhamno-polyene with a linear chain of 12 conjugated double bonds, named granadaene, which may help understand its biosynthetic pathway and the role of cyl-genes in the universal linkage between pigment and hemolytic activity in GBS.

Published
2006

33. Herramienta de modelado de dominio específico (DSM) para la creación de módulos en sistemas de gestión del aprendizaje (LMS)

Author

Montenegro Marín, Carlos E., Gaona, Alonso, Cuerva, Juan Manuel, Sanjuán Martínez, Óscar, Montenegro Marín, Carlos E., Gaona, Alonso, Cuerva, Juan Manuel, and Sanjuán Martínez, Óscar

Abstract

The general objective is to make domain-specific modeling for the construction of modules of learning management systems (LMS) platform independent. For this, the start point is a metamodel for the contruction a domain specific language (DSL), that with model-driven engineering (MDE) and applying the appropriate transformations are achieved from a independent model platform, deploy this model with LMS modules in moodle.

Published
2011

34. Amide-Substituted Titanocenes in Hydrogen-Atom Transfer Catalysis.

Author

Zhang, Yong-Qiang, Jakoby, Verena, Stainer, Katharina, Schmer, Alexander, Klare, Sven, Bauer, Mirko, Grimme, Stefan, Cuerva, Juan Manuel, and Gansäuer, Andreas

Subjects
HYDROGEN-deuterium exchange, HYDROGEN atom, SCHRODINGER'S equation for the hydrogen atom, SURFACE chemistry, CATALYSIS
Abstract

Two new catalytic systems for hydrogen-atom transfer (HAT) catalysis involving the N−H bonds of titanocene(III) complexes with pendant amide ligands are reported. In a monometallic system, a bifunctional catalyst for radical generation and reduction through HAT catalysis depending on the coordination of the amide ligand is employed. The pendant amide ligand is used to activate Crabtree's catalyst to yield an efficient bimetallic system for radical generation and HAT catalysis. [ABSTRACT FROM AUTHOR]

Published
2016
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35. Amid-substituierte Titanocene für die H-Atom-Transfer-Katalyse.

Author

Zhang, Yong‐Qiang, Jakoby, Verena, Stainer, Katharina, Schmer, Alexander, Klare, Sven, Bauer, Mirko, Grimme, Stefan, Cuerva, Juan Manuel, and Gansäuer, Andreas

Abstract

Copyright of Angewandte Chemie is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
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41. Cationic Intermediates in the Intramolecular Insertion of Alkenes into (?3-Allyl)palladium(II) Complexes

Author

Gómez-Bengoa, Enrique, Cuerva, Juan Manuel, Echavarren, Antonio M., and Martorell, Gabriel

Abstract

The palladium-catalyzed carbocyclizationof allyl carboxylates with alkenes developed by Oppolzer proceeds smoothly via cationic complexes (depicted schematically on the right). In contrast, complexes with two donor phosphane ligands or a bidentate ligand are not productive intermediates in the cyclization process.

Published
1997
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43. Titelbild: Amid-substituierte Titanocene für die H-Atom-Transfer-Katalyse (Angew. Chem. 4/2016).

Author

Zhang, Yong‐Qiang, Jakoby, Verena, Stainer, Katharina, Schmer, Alexander, Klare, Sven, Bauer, Mirko, Grimme, Stefan, Cuerva, Juan Manuel, and Gansäuer, Andreas

Subjects
CHEMISTRY periodicals
Abstract

Einem katalytischen Tango gleicht die Kopplung der Katalysezyklen in der difunktionellen Metall‐Ligand‐ oder in der kooperativen Katalyse. In ihrer Zuschrift auf S. 1546 ff. zeigen A. Gansäuer et al., dass Amide durch amidsubstituierte Titanocen(III)‐Katalysatoren oder durch kooperative Katalyse mit Titanocen und Crabtrees Katalysator für die radikalische Reduktion aktiviert werden können (Graphik: Dina Schwarz G. Henriques). [ABSTRACT FROM AUTHOR]

Published
2016
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44. In situ real-time monitoring of the mechanism of self-assembly of short peptide supramolecular polymers

Author

Mari C. Mañas-Torres, Juan A. González-Vera, Víctor Blanco, Modesto T. López-López, Juan M. Cuerva, Luis Álvarez de Cienfuegos, Angel Orte, Francisco Conejero-Lara, Cristina Gila-Vilchez, [Manas-Torres, Mari C.] Univ Granada UGR, Fac Ciencias, Dept Quim Organ, Granada 18071, Spain, [Blanco, Victor] Univ Granada UGR, Fac Ciencias, Dept Quim Organ, Granada 18071, Spain, [Cuerva, Juan Manuel] Univ Granada UGR, Fac Ciencias, Dept Quim Organ, Granada 18071, Spain, [Alvarez de Cienfuegos, Luis] Univ Granada UGR, Fac Ciencias, Dept Quim Organ, Granada 18071, Spain, [Gila-Vilchez, Cristina] UGR, Fac Ciencias, Dept Fis Aplicada, Granada, Spain, [Lopez-Lopez, Modesto T.] UGR, Fac Ciencias, Dept Fis Aplicada, Granada, Spain, [Gonzalez-Vera, Juan A.] UGR, Fac Farm, Dept Fis Quim, Granada 18072, Spain, [Orte, Angel] UGR, Fac Farm, Dept Fis Quim, Granada 18072, Spain, [Conejero-Lara, Francisco] UGR, Fac Ciencias, Dept Quim Fis, Granada, Spain, [Lopez-Lopez, Modesto T.] Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain, [Alvarez de Cienfuegos, Luis] Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain, Ministerio de Economia, Industria y Competitividad, MINECO, Agencia Estatal de Investigacion, AEI, Spain, Fondo Europeo de Desarrollo Regional, FEDER, European Union, FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades (Spain), and Ministerio de Ciencia e Innovacion/Agencia Estatal de Investigacion

Subjects
chemistry.chemical_classification, Fluorescence-lifetime imaging microscopy, Chemistry, Kinetics, Proliferation, Pathway complexity, Hydrogels, Fluorescence, Supramolecular polymers, Dipeptide, Micellar, Self-healing hydrogels, Materials Chemistry, Biophysics, Nucleation, General Materials Science, Interphase, Fiber, Self-assembly, Networks, Gels, Stability, Spectroscopy
Abstract

This study was supported by projects CTQ2017-86568-R and FIS2017-85954-R (Ministerio de Economia, Industria y Competitividad, MINECO, and Agencia Estatal de Investigacion, AEI, Spain, cofunded by Fondo Europeo de Desarrollo Regional, FEDER, European Union), and by FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades (Spain) project P18-FR-3533. We want to thank "Unidad de Excelencia Quimica aplicada a Biomedicina y Medioambiente" of the University of Granada. Thanks go to the CIC personnel of the University of Granada for technical assistance. We thank the Centro de Servicios de Informatica y Redes de Comunicaciones (CSIRC), Universidad de Granada, for providing the computing time. Authors acknowledge to Dr Rosario Herranz and Dr Francisco Fueyo-Gonzalez for the fluorophore 9-azetidinyl-5-butyl-quinolimide (AQui) used in this study, which was synthesized at Instituto de Quimica Medica-CSIC (IQM-CSIC) with the support of the Ministerio de Ciencia e Innovacion/Agencia Estatal de Investigacion grant FU2015-67284-R., Making use of the combination of multiparametric Fluorescence Lifetime Imaging Microscopy (FLIM) and single-molecule Fluorescence Lifetime Correlation Spectroscopy (FLCS), we have been able to study for the early stages of the fluorenylmethyloxycarbonyl-diphenylalanine (Fmoc-FF) self-assembly process with single-molecule resolution, the kinetics of fiber formation, the packaging of the peptides within the fibers and the capacity of the peptides to reassemble after disruption (self-healing) in the presence of different metallic cations. Other techniques such as FTIR, TEM, DSC and DFT calculations support our findings. The impact that the mechanism of self-assembly has on the physical (rigidity and self-healing) properties of the resulting gels have also been evaluated by rheology. Calcium ions are able to promote the self-assembly of Fmoc-FF faster and more efficiently, forming more rigid hydrogels than do cesium ions. The reasons behind this effect may be explained by the different capacities that these two cations have to coordinate with the peptide, modulate its hydrophobicity and stabilize the water-solute interphase. These findings shed light on the impact that small changes have on the process of self-assembly and can help to understand the influence of the environmental conditions on the in vivo uncontrolled self-assembly of certain proteins., Ministerio de Economia, Industria y Competitividad, MINECO CTQ2017-86568-R FIS2017-85954-R, Agencia Estatal de Investigacion, AEI, Spain CTQ2017-86568-R FIS2017-85954-R, Fondo Europeo de Desarrollo Regional, FEDER, European Union CTQ2017-86568-R FIS2017-85954-R, FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades (Spain) P18-FR-3533, Ministerio de Ciencia e Innovacion/Agencia Estatal de Investigacion FU2015-67284-R

Published
2021

45. Amide-Substituted Titanocenes in Hydrogen-Atom Transfer Catalysis.

Author

Zhang YQ, Jakoby V, Stainer K, Schmer A, Klare S, Bauer M, Grimme S, Cuerva JM, and Gansäuer A

Abstract

Two new catalytic systems for hydrogen-atom transfer (HAT) catalysis involving the N-H bonds of titanocene(III) complexes with pendant amide ligands are reported. In a monometallic system, a bifunctional catalyst for radical generation and reduction through HAT catalysis depending on the coordination of the amide ligand is employed. The pendant amide ligand is used to activate Crabtree's catalyst to yield an efficient bimetallic system for radical generation and HAT catalysis., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2016
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