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1. Outcomes with General Anesthesia Compared to Conscious Sedation for Endovascular Treatment of Medium Vessel Occlusions: Results of an International Multicentric Study

Author

Radu, Răzvan Alexandru, Costalat, Vincent, Romoli, Michele, Musmar, Basel, Siegler, James E., Ghozy, Sherief, Khalife, Jane, Salim, Hamza, Shaikh, Hamza, Adeeb, Nimer, Cuellar-Saenz, Hugo H., Thomas, Ajith J., Kadirvel, Ramanathan, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Regenhardt, Robert W., Bernstock, Joshua D., Patel, Aman B., Rabinov, James D., Stapleton, Christopher J., Cancelliere, Nicole M., Marotta, Thomas R., Mendes Pereira, Vitor, El Naamani, Kareem, Amllay, Abdelaziz, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Meyer, Lukas, Fiehler, Jens, Faizy, Tobias D., Guerreiro, Helena, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Mounayer, Charbel, Kühn, Anna Luisa, Puri, Ajit S., Dyzmann, Christian, Kan, Peter T., Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard L. L., Tan, Benjamin YQ, Gopinathan, Anil, Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Chervak, Lina M., Vagal, Achala, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Alexandre, Andrea M., Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., YMD, Markus A., Jesser, Jessica, Weyland, Charlotte, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Aziz, Yasmin, Gory, Benjamin, Paul Stracke, Christian, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Hsieh, Cheng-Yang, Liebeskind, David S., Tancredi, Illario, Fahed, Robert, Lubicz, Boris, Essibayi, Muhammed Amir, Baker, Amanda, Altschul, David, Scarcia, Luca, Kalsoum, Erwah, Dmytriw, Adam A., and Guenego, Adrien

Published
2024
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2. Dual Layer vs Single Layer Woven EndoBridge Device in the Treatment of Intracranial Aneurysms: A Propensity Score-Matched Analysis

Author

Dmytriw, Adam A., Salim, Hamza, Musmar, Basel, Aslan, Assala, Cancelliere, Nicole M., McLellan, Rachel M., Algin, Oktay, Ghozy, Sherief, Dibas, Mahmoud, Lay, Sovann V., Guenego, Adrien, Renieri, Leonardo, Carnevale, Joseph, Saliou, Guillaume, Mastorakos, Panagiotis, Naamani, Kareem El, Shotar, Eimad, Premat, Kevin, Möhlenbruch, Markus, Kral, Michael, Doron, Omer, Chung, Charlotte, Salem, Mohamed M., Lylyk, Ivan, Foreman, Paul M., Vachhani, Jay A., Shaikh, Hamza, Župančić, Vedran, Hafeez, Muhammad U., Catapano, Joshua, Waqas, Muhammad, Tutino, Vincent M., Ibrahim, Mohamed K., Mohammed, Marwa A., Imamoglu, Cetin, Bayrak, Ahmet, Rabinov, James D., Ren, Yifan, Schirmer, Clemens M., Piano, Mariangela, Kühn, Anna L., Michelozzi, Caterina, Elens, Stéphanie, Starke, Robert M., Hassan, Ameer E., Ogilvie, Mark, Sporns, Peter, Jones, Jesse, Brinjikji, Waleed, Nawka, Marie T., Psychogios, Marios, Ulfert, Christian, Diestro, Jose Danilo Bengzon, Pukenas, Bryan, Burkhardt, Jan-Karl, Huynh, Thien, Martinez-Gutierrez, Juan Carlos, Essibayi, Muhammed Amir, Sheth, Sunil A., Spiegel, Gary, Tawk, Rabih, Lubicz, Boris, Panni, Pietro, Puri, Ajit S., Pero, Guglielmo, Nossek, Erez, Raz, Eytan, Killer-Oberfalzer, Monika, Griessenauer, Christoph J., Asadi, Hamed, Siddiqui, Adnan, Brook, Allan L., Altschul, David, Ducruet, Andrew F., Albuquerque, Felipe C., Regenhardt, Robert W., Stapleton, Christopher J., Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Boddu, Srikanth, Knopman, Jared, Aziz-Sultan, Mohammad A., Tjoumakaris, Stavropoula I., Clarençon, Frédéric, Limbucci, Nicola, Cuellar-Saenz, Hugo H., Jabbour, Pascal M., Pereira, Vitor Mendes, Patel, Aman B., and Adeeb, Nimer

Published
2024
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3. Long-Term Follow-Up of Cerebral Aneurysms Completely Occluded at 6 Months After Intervention with the Woven EndoBridge (WEB) Device: a Retrospective Multicenter Observational Study

Author

El Naamani, Kareem, Mastorakos, Panagiotis, Adeeb, Nimer, Lan, Mathews, Castiglione, James, Khanna, Omaditya, Diestro, Jose Danilo Bengzon, McLellan, Rachel M., Dibas, Mahmoud, Vranic, Justin E., Aslan, Assala, Cuellar-Saenz, Hugo H., Guenego, Adrien, Carnevale, Joseph, Saliou, Guillaume, Ulfert, Christian, Möhlenbruch, Markus, Foreman, Paul M., Vachhani, Jay A., Hafeez, Muhammad U., Waqas, Muhammad, Tutino, Vincent M., Rabinov, James D., Ren, Yifan, Michelozzi, Caterina, Spears, Julian, Panni, Pietro, Griessenauer, Christoph J., Asadi, Hamed, Regenhardt, Robert W., Stapleton, Christopher J., Ghozy, Sherief, Siddiqui, Adnan, Patel, Nirav J., Kan, Peter, Boddu, Srikanth, Knopman, Jared, Aziz-Sultan, Mohammad A., Zanaty, Mario, Ghosh, Ritam, Abbas, Rawad, Amllay, Abdelaziz, Tjoumakaris, Stavropoula I., Gooch, Michael R., Cancelliere, Nicole M., Herial, Nabeel A., Rosenwasser, Robert H., Zarzour, Hekmat, Schmidt, Richard F., Pereira, Vitor Mendes, Patel, Aman B., Jabbour, Pascal, and Dmytriw, Adam A.

Published
2024
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4. Off-Label use of Woven EndoBridge device for intracranial brain aneurysm treatment: Modeling of occlusion outcome

Author

Dibas, Mahmoud, Spears, Julian, Sundararajan, Sri Hari, Al Balush, Ali, Vranic, Justin E., Inoue, Yasuaki, Mirshahi, Shervin, Alotaibi, Naif M., Harker, Pablo, Tutino, Vincent M., Sporns, Peter, Brehm, Alex, Essibayi, Muhammed Amir, Jabal, Mohamed Sobhi, Musmar, Basel, Adeeb, Nimer, Salim, Hamza, Aslan, Assala, Cancelliere, Nicole M., McLellan, Rachel M., Algin, Oktay, Ghozy, Sherief, Lay, Sovann V., Guenego, Adrien, Renieri, Leonardo, Carnevale, Joseph, Saliou, Guillaume, Mastorakos, Panagiotis, Naamani, Kareem El, Shotar, Eimad, Premat, Kevin, Möhlenbruch, Markus, Kral, Michael, Doron, Omer, Chung, Charlotte, Salem, Mohamed M, Lylyk, Ivan, Foreman, Paul M., Vachhani, Jay A., Shaikh, Hamza, Župančić, Vedran, Hafeez, Muhammad U., Catapano, Joshua, Waqas, Muhammad, Yavuz, Kivilcim, Gunes, Yasin Celal, Rabinov, James D., Ren, Yifan, Schirmer, Clemens M., Piano, Mariangela, Kühn, Anna L., Michelozzi, Caterina, Starke, Robert M., Hassan, Ameer, Ogilvie, Mark, Nguyen, Anh, Jones, Jesse, Brinjikji, Waleed, Nawka, Marie T., Psychogios, Marios, Ulfert, Christian, Diestro, Jose Danilo Bengzon, Pukenas, Bryan, Burkhardt, Jan-Karl, Huynh, Thien, Gutierrez, Juan Carlos Martinez, Sheth, Sunil A., Spiegel, Gary, Tawk, Rabih, Lubicz, Boris, Panni, Pietro, Puri, Ajit S., Pero, Guglielmo, Nossek, Erez, Raz, Eytan, Killer-Oberfalzer, Monika, Griessenauer, Christoph J., Asadi, Hamed, Siddiqui, Adnan, Brook, Allan L., Haranhalli, Neil, Ducruet, Andrew F., Albuquerque, Felipe C., Regenhardt, Robert W., Stapleton, Christopher J., Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Boddu, Srikanth, Knopman, Jared, Aziz-Sultan, Mohammad A., Tjoumakaris, Stavropoula I., Clarençon, Frédéric, Limbucci, Nicola, Cuellar-Saenz, Hugo H., Jabbour, Pascal M, Pereira, Vitor Mendes, Patel, Aman B., Altschul, David, and Dmytriw, Adam A.

Published
2024
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5. The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium

Author

Dmytriw, Adam A., Dibas, Mahmoud, Ghozy, Sherief, Adeeb, Nimer, Diestro, Jose Danilo Bengzon, Phan, Kevin, Cuellar-Saenz, Hugo H., Sweid, Ahmad, Lay, Sovann V., Guenego, Adrien, Renieri, Leonardo, Al Balushi, Ali, Saliou, Guillaume, Möhlenbruch, Markus, Regenhardt, Robert W., Vranic, Justin E., Lylyk, Ivan, Foreman, Paul M., Vachhani, Jay A., Župančić, Vedran, Hafeez, Muhammad U., Rutledge, Caleb, Waqas, Muhammad, Tutino, Vincent M., Rabinov, James D., Ren, Yifan, Schirmer, Clemens M., Piano, Mariangela, Kühn, Anna L., Michelozzi, Caterina, Elens, Stéphanie, Starke, Robert M., Hassan, Ameer, Salehani, Arsalaan, Sporns, Peter, Jones, Jesse, Psychogios, Marios, Spears, Julian, Lubicz, Boris, Panni, Pietro, Puri, Ajit S., Pero, Guglielmo, Griessenauer, Christoph J., Asadi, Hamed, Stapleton, Christopher J., Siddiqui, Adnan, Ducruet, Andrew F., Albuquerque, Felipe C., Du, Rose, Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Boddu, Srikanth, Tjoumakaris, Stavropoula, Knopman, Jared, Aziz-Sultan, Mohammad A., Limbucci, Nicola, Jabbour, Pascal, Cognard, Christophe, and Patel, Aman B.

Published
2023
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6. Correction to: The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium

Author

Dmytriw, Adam A., Dibas, Mahmoud, Ghozy, Sherief, Adeeb, Nimer, Diestro, Jose Danilo Bengzon, Phan, Kevin, Cuellar-Saenz, Hugo H., Sweid, Ahmad, Lay, Sovann V., Guenego, Adrien, Renieri, Leonardo, Al Balushi, Ali, Saliou, Guillaume, Möhlenbruch, Markus, Regenhardt, Robert W., Vranic, Justin E., Lylyk, Ivan, Foreman, Paul M., Vachhani, Jay A., Župančić, Vedran, Hafeez, Muhammad U., Rutledge, Caleb, Waqas, Muhammad, Tutino, Vincent M., Rabinov, James D., Ren, Yifan, Schirmer, Clemens M., Piano, Mariangela, Kühn, Anna L., Michelozzi, Caterina, Elens, Stéphanie, Starke, Robert M., Hassan, Ameer, Salehani, Arsalaan, Sporns, Peter, Jones, Jesse, Psychogios, Marios, Spears, Julian, Lubicz, Boris, Panni, Pietro, Puri, Ajit S., Pero, Guglielmo, Griessenauer, Christoph J., Asadi, Hamed, Stapleton, Christopher J., Siddiqui, Adnan, Ducruet, Andrew F., Albuquerque, Felipe C., Du, Rose, Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Boddu, Srikanth, Tjoumakaris, Stavropoula, Jared Knopman, Aziz-Sultan, Mohammad A., Limbucci, Nicola, Jabbour, Pascal, Cognard, Christophe, and Patel, Aman B.

Published
2023
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7. Outcomes of mechanical thrombectomy in anticoagulated patients with acute distal and medium vessel stroke

Author

Salim, Hamza, primary, Musmar, Basel, additional, Adeeb, Nimer, additional, Yedavalli, Vivek, additional, Lakhani, Dhairya, additional, Grewal, Sahibjot Singh, additional, El Naamani, Kareem, additional, Henninger, Nils, additional, Sundararajan, Sri Hari, additional, Kühn, Anna Luisa, additional, Khalife, Jane, additional, Ghozy, Sherief, additional, Scarcia, Luca, additional, Tan, Benjamin YQ, additional, Regenhardt, Robert W, additional, Heit, Jeremy J, additional, Cancelliere, Nicole M, additional, Bernstock, Joshua D, additional, Rouchaud, Aymeric, additional, Fiehler, Jens, additional, Sheth, Sunil, additional, Puri, Ajit S, additional, Dyzmann, Christian, additional, Colasurdo, Marco, additional, Barreau, Xavier, additional, Renieri, Leonardo, additional, Filipe, João Pedro, additional, Harker, Pablo, additional, Radu, Răzvan Alexandru, additional, Abdalkader, Mohamad, additional, Klein, Piers, additional, Marotta, Thomas R, additional, Spears, Julian, additional, Ota, Takahiro, additional, Mowla, Ashkan, additional, Jabbour, Pascal, additional, Biswas, Arundhati, additional, Clarençon, Frédéric, additional, Siegler, James E, additional, Nguyen, Thanh N, additional, Varela, Ricardo, additional, Baker, Amanda, additional, Essibayi, Muhammed Amir, additional, Altschul, David, additional, Gonzalez, Nestor R, additional, Möhlenbruch, Markus A, additional, Costalat, Vincent, additional, Gory, Benjamin, additional, Stracke, Christian Paul, additional, Aziz-Sultan, Mohammad Ali, additional, Hecker, Constantin, additional, Shaikh, Hamza, additional, Liebeskind, David S, additional, Pedicelli, Alessandro, additional, Alexandre, Andrea M, additional, Tancredi, Illario, additional, Faizy, Tobias D, additional, Kalsoum, Erwah, additional, Lubicz, Boris, additional, Patel, Aman B, additional, Pereira, Vitor Mendes, additional, Guenego, Adrien, additional, Dmytriw, Adam A, additional, Amllay, Abdelaziz, additional, Vagal, Achala, additional, ter Schiphorst, Adrien, additional, Thomas, Ajith J., additional, Gopinathan, Anil, additional, Dusart, Anne, additional, Capirossi, Carolina, additional, Mounayer, Charbel, additional, Weyland, Charlotte, additional, Hsieh, Cheng-Yang, additional, Griessenauer, Christoph J., additional, Stapleton, Christopher J., additional, Bellante, Flavio, additional, Marnat, Gaultier, additional, Forestier, Géraud, additional, Cuellar-Saenz, Hugo H., additional, Valente, Iacopo, additional, Sibon, Igor, additional, Rabinov, James D., additional, Berge, Jérôme, additional, Jesser, Jessica, additional, Carlos Martinez-Gutierrez, Juan, additional, Premat, Kevin, additional, Yeo, Leonard LL., additional, Chervak, Lina, additional, Meyer, Lukas, additional, Elhorany, Mahmoud, additional, and Quintero-Consuegra, Miguel, additional

Published
2024
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9. International Study of Intracranial Aneurysm Treatment Using Woven EndoBridge: Results of the WorldWideWEB Consortium

Author

Dmytriw, Adam A., Diestro, Jose Danilo Bengzon, Dibas, Mahmoud, Phan, Kevin, Sweid, Ahmad, Cuellar-Saenz, Hugo H., Lay, Sovann V., Guenego, Adrien, Renieri, Leonardo, Al Balushi, Ali, Sundararajan, Sri Hari, Carnevale, Joseph, Saliou, Guillaume, Möhlenbruch, Markus, Vranic, Justin E., Rabinov, James D., Lylyk, Ivan, Foreman, Paul M., Vachhani, Jay A., Župančić, Vedran, Hafeez, Muhammad U., Rutledge, Caleb, Waqas, Muhammad, Tutino, Vincent M., Abbas, Rawad, Inoue, Yasuaki, Capirossi, Carolina, Ren, Yifan, Schirmer, Clemens M., Piano, Mariangela, Kühn, Anna Luisa, Michelozzi, Caterina, Elens, Stéphanie, Regenhardt, Robert W., Ghozy, Sherief, Alotaibi, Naif M., Tjoumakaris, Stavropoula, Starke, Robert M., Lubicz, Boris, Panni, Pietro, Puri, Ajit S., Pero, Guglielmo, Griessenauer, Christoph J., Asadi, Hamed, Brooks, Mark, Maingard, Julian, Jhamb, Ashu, Siddiqui, Adnan, Ducruet, Andrew F., Albuquerque, Felipe C., Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Savardekar, Amey, Boddu, Srikanth, Knopman, Jared, Limbucci, Nicola, Chen, Karen S., Aziz-Sultan, Mohammad A., Stapleton, Christopher J., Jabbour, Pascal, Cognard, Christophe, Patel, Aman B., and Adeeb, Nimer

Published
2021
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10. Predictors of Aneurysm Obliteration in Patients Treated with the WEB Device: Results of a Multicenter Retrospective Study.

Author

Mastorakos, Panagiotis, El Naamani, Kareem, Adeeb, Nimer, Lan, Mathews, Castiglione, James, Khanna, Omaditya, Ghosh, Ritam, Bengzon Diestro, Jose Danilo, Dibas, Mahmoud, McLellan, Rachel M., Algin, Oktay, Ghozy, Sherief, Cancelliere, Nicole M., Aslan, Assala, Cuellar-Saenz, Hugo H., Lay, Sovann V., Guenego, Adrien, Renieri, Leonardo, Carnevale, Joseph, and Saliou, Guillaume

Published
2024
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11. Morphological characteristics of brain aneurysms among age groups

Author

Sanchez, Sebastian, primary, Essibayi, Muhammed Amir, additional, Hickerson, Meredith, additional, Ojeda, Diego J, additional, Kasab, Sami Al, additional, Yoshimura, Shinichi, additional, Jabbour, Pascal M., additional, Mascitelli, Justin, additional, Levitt, Michael R., additional, Cuellar-Saenz, Hugo H., additional, Brinjikji, Waleed, additional, Spiotta, Alejandro M., additional, Shaban, Amir, additional, and Samaniego, Edgar A, additional

Published
2023
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14. Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation

Author

Senchenkova, Elena Y., Ansari, Junaid, Becker, Felix, Vital, Shantel A., Al-Yafeai, Zaki, Sparkenbaugh, Erica M., Pawlinski, Rafal, Stokes, Karen Y., Carroll, Jennifer L., Dragoi, Ana-Maria, Qin, Cheng Xue, Ritchie, Rebecca H., Sun, Hai, Cuellar-Saenz, Hugo H., Rubinstein, Mara R., Han, Yiping W., Orr, A. Wayne, Perretti, Mauro, Granger, D. Neil, and Gavins, Felicity N.E.

Published
2019
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15. Risk factors and predictors of intracranial hemorrhage after mechanical thrombectomy in acute ischemic stroke: insights from the Stroke Thrombectomy and Aneurysm Registry (STAR)

Author

Ironside, Natasha, primary, Chen, Ching-Jen, additional, Chalhoub, Reda M, additional, Kellogg, Ryan T, additional, Ding, Dale, additional, Maier, Ilko, additional, Al Kasab, Sami, additional, Jabbour, Pascal, additional, Kim, Joon-tae, additional, Wolfe, Stacey Q, additional, Rai, Ansaar, additional, Starke, Robert M, additional, Psychogios, Marios-Nikos, additional, Shaban, Amir, additional, Arthur, Adam S, additional, Yoshimura, Shinichi, additional, Grossberg, Jonathan A, additional, Alawieh, Ali, additional, Fragata, Isabel, additional, Polifka, Adam J, additional, Mascitelli, Justin R, additional, Osbun, Joshua W, additional, Matouk, Charles, additional, Levitt, Michael R, additional, Dumont, Travis M, additional, Cuellar-Saenz, Hugo H, additional, Williamson, Richard, additional, Romano, Daniele G, additional, Crosa, Roberto Javier, additional, Gory, Benjamin, additional, Mokin, Maxim, additional, Moss, Mark, additional, Limaye, Kaustubh, additional, Kan, Peter, additional, Spiotta, Alejandro M, additional, and Park, Min S, additional

Published
2023
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16. Technical and clinical outcomes in concurrent multivessel occlusions treated with mechanical thrombectomy: insights from the STAR collaboration

Author

Saad, Hassan, primary, Eshraghi, Sheila, additional, Alawieh, Ali M, additional, Akbik, Feras, additional, Cawley, C Michael, additional, Howard, Brian M, additional, Ash, Makenna, additional, Hsu, Alice, additional, Pabaney, Aqueel, additional, Maier, Ilko, additional, Al Kasab, Sami, additional, El Naamani, Kareem, additional, Jabbour, Pascal, additional, Kim, Joon-tae, additional, Wolfe, Stacey Q, additional, Rai, Ansaar, additional, Starke, Robert M, additional, Psychogios, Marios-Nikos, additional, Shaban, Amir, additional, Arthur, Adam S, additional, Yoshimura, Shinichi, additional, Fragata, Isabel, additional, Cuellar-Saenz, Hugo H, additional, Polifka, Adam J, additional, Mascitelli, Justin, additional, Osbun, Joshua W, additional, Matouk, Charles, additional, Park, Min S, additional, Levitt, Michael R, additional, Dumont, Travis M, additional, Williamson, Richard, additional, Spiotta, Alejandro M, additional, and Grossberg, Jonathan A, additional

Published
2022
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17. The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium

Author

Dmytriw, Adam A., primary, Dibas, Mahmoud, additional, Ghozy, Sherief, additional, Adeeb, Nimer, additional, Diestro, Jose Danilo Bengzon, additional, Phan, Kevin, additional, Cuellar-Saenz, Hugo H., additional, Sweid, Ahmad, additional, Lay, Sovann V., additional, Guenego, Adrien, additional, Renieri, Leonardo, additional, Al Balushi, Ali, additional, Saliou, Guillaume, additional, Möhlenbruch, Markus, additional, Regenhardt, Robert W., additional, Vranic, Justin E., additional, Lylyk, Ivan, additional, Foreman, Paul M., additional, Vachhani, Jay A., additional, Župančić, Vedran, additional, Hafeez, Muhammad U., additional, Rutledge, Caleb, additional, Waqas, Muhammad, additional, Tutino, Vincent M., additional, Rabinov, James D., additional, Ren, Yifan, additional, Schirmer, Clemens M., additional, Piano, Mariangela, additional, Kühn, Anna L., additional, Michelozzi, Caterina, additional, Elens, Stéphanie, additional, Starke, Robert M., additional, Hassan, Ameer, additional, Salehani, Arsalaan, additional, Sporns, Peter, additional, Jones, Jesse, additional, Psychogios, Marios, additional, Spears, Julian, additional, Lubicz, Boris, additional, Panni, Pietro, additional, Puri, Ajit S., additional, Pero, Guglielmo, additional, Griessenauer, Christoph J., additional, Asadi, Hamed, additional, Stapleton, Christopher J., additional, Siddiqui, Adnan, additional, Ducruet, Andrew F., additional, Albuquerque, Felipe C., additional, Du, Rose, additional, Kan, Peter, additional, Kalousek, Vladimir, additional, Lylyk, Pedro, additional, Boddu, Srikanth, additional, Tjoumakaris, Stavropoula, additional, Knopman, Jared, additional, Aziz-Sultan, Mohammad A., additional, Limbucci, Nicola, additional, Jabbour, Pascal, additional, Cognard, Christophe, additional, and Patel, Aman B., additional

Published
2022
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18. Multicenter Study for the Treatment of Sidewall versus Bifurcation Intracranial Aneurysms with Use of Woven EndoBridge (WEB)

Author

Adeeb, Nimer, primary, Dibas, Mahmoud, additional, Diestro, Jose Danilo Bengzon, additional, Cuellar-Saenz, Hugo H., additional, Sweid, Ahmad, additional, Kandregula, Sandeep, additional, Lay, Sovann V., additional, Guenego, Adrien, additional, Renieri, Leonardo, additional, Sundararajan, Sri Hari, additional, Saliou, Guillaume, additional, Aslan, Assala, additional, Möhlenbruch, Markus, additional, Vranic, Justin E., additional, Regenhardt, Robert W., additional, Savardekar, Amey, additional, Mamilly, Ahmed, additional, Lylyk, Ivan, additional, Foreman, Paul M., additional, Vachhani, Jay A., additional, Župančić, Vedran, additional, Hafeez, Muhammad U., additional, Rutledge, Caleb, additional, Waqas, Muhammad, additional, Parra Farinas, Carmen, additional, Tutino, Vincent M., additional, Inoue, Yasuaki, additional, Mirshahi, Shervin, additional, Rabinov, James D., additional, Ren, Yifan, additional, Schirmer, Clemens M., additional, Piano, Mariangela, additional, Kühn, Anna L., additional, Michelozzi, Caterina, additional, Elens, Stéphanie, additional, Starke, Robert M., additional, Hassan, Ameer, additional, Salehani, Arsalaan, additional, Sporns, Peter, additional, Brehm, Alex, additional, Jones, Jesse, additional, Psychogios, Marios, additional, Spears, Julian, additional, Lubicz, Boris, additional, Panni, Pietro, additional, Puri, Ajit S., additional, Pero, Guglielmo, additional, Griessenauer, Christoph J., additional, Asadi, Hamed, additional, Stapleton, Christopher J., additional, Siddiqui, Adnan, additional, Ducruet, Andrew F., additional, Albuquerque, Felipe C., additional, Kan, Peter, additional, Kalousek, Vladimir, additional, Lylyk, Pedro, additional, Boddu, Srikanth, additional, Knopman, Jared, additional, Aziz-Sultan, Mohammad A., additional, Limbucci, Nicola, additional, Jabbour, Pascal, additional, Cognard, Christophe, additional, Patel, Aman B., additional, and Dmytriw, Adam A., additional

Published
2022
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19. Comparing treatment outcomes of various intracranial bifurcation aneurysms locations using the Woven EndoBridge (WEB) device.

Author

Adeeb, Nimer, Dibas, Mahmoud, Diestro, Jose Danilo Bengzon, Phan, Kevin, Cuellar-Saenz, Hugo H., Sweid, Ahmad, Lay, Sovann V., Guenego, Adrien, Aslan, Assala, Renieri, Leonardo, Sundararajan, Sri Hari, Saliou, Guillaume, Möhlenbruch, Markus, Regenhardt, Robert W., Vranic, Justin E., Lylyk, Ivan, Foreman, Paul M., Vachhani, Jay A., Župančić, Vedran, and Hafeez, Muhammad U.

Subjects
CAROTID artery diseases, ACADEMIC medical centers, THERAPEUTIC embolization, RETROSPECTIVE studies, TREATMENT effectiveness, COMPARATIVE studies, ENDOVASCULAR surgery, INTRACRANIAL aneurysms, LONGITUDINAL method
Abstract

Background The Woven EndoBridge (WEB) device has Food and Drug Administration approval for treatment of wide-necked intracranial bifurcation aneurysms. The WEB device has been shown to result in adequate occlusion in bifurcation aneurysms overall, but its usefulness in the individual bifurcation locations has been evaluated separately only in few case series, which were limited by small sample sizes. Objective To compare angiographic and clinical outcomes after treatment of bifurcation aneurysms at various locations, including anterior communicating artery (AComA), anterior cerebral artery (ACA) bifurcation distal to AComA, basilar tip, internal carotid artery (ICA) bifurcation, and middle cerebral artery (MCA) bifurcation aneurysms using the WEB device. Methods A retrospective cohort analysis was conducted at 22 academic institutions worldwide to compare treatment outcomes of patients with intracranial bifurcation aneurysms using the WEB device. Data include patient and aneurysm characteristics, procedural details, angiographic and functional outcomes, and complications. Results A total of 572 aneurysms were included. MCA (36%), AComA (35.7%), and basilar tip (18.9%) aneurysms were most common. The rate of adequate aneurysm occlusion was significantly higher for basilar tip (91.6%) and ICA bifurcation (96.7%) aneurysms and lower for ACA bifurcation (71.4%) and AComA (80.6%) aneurysms (p=0.04). Conclusion To our knowledge, this is the most extensive study to date that compares the treatment of different intracranial bifurcation aneurysms using the WEB device. Basilar tip and ICA bifurcation aneurysms showed significantly higher rates of aneurysm occlusion than other locations. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Intrasaccular flow disruption for ruptured aneurysms: an international multicenter study

Author

Diestro, Jose Danilo Bengzon, primary, Dibas, Mahmoud, additional, Adeeb, Nimer, additional, Regenhardt, Robert W, additional, Vranic, Justin E, additional, Guenego, Adrien, additional, Lay, Sovann V, additional, Renieri, Leonardo, additional, Al Balushi, Ali, additional, Shotar, Eimad, additional, Premat, Kevin, additional, El Naamani, Kareem, additional, Saliou, Guillaume, additional, Möhlenbruch, Markus A., additional, Lylyk, Ivan, additional, Foreman, Paul M, additional, Vachhani, Jay A, additional, Župančić, Vedran, additional, Hafeez, Muhammad U, additional, Rutledge, Caleb, additional, Rai, Hamid, additional, Tutino, Vincent M, additional, Mirshani, Shervin, additional, Ghozy, Sherief, additional, Harker, Pablo, additional, Alotaibi, Naif M, additional, Rabinov, James D, additional, Ren, Yifan, additional, Schirmer, Clemens M, additional, Goren, Oded, additional, Piano, Mariangela, additional, Kuhn, Anna Luisa, additional, Michelozzi, Caterina, additional, Elens, Stephanie, additional, Starke, Robert M, additional, Hassan, Ameer, additional, Salehani, Arsalaan, additional, Nguyen, Anh, additional, Jones, Jesse, additional, Psychogios, Marios, additional, Spears, Julian, additional, Parra-Fariñas, Carmen, additional, Bres Bullrich, Maria, additional, Mayich, Michael, additional, Salem, Mohamed M, additional, Burkhardt, Jan-Karl, additional, Jankowitz, Brian T, additional, Domingo, Ricardo A, additional, Huynh, Thien, additional, Tawk, Rabih, additional, Ulfert, Christian, additional, Lubicz, Boris, additional, Panni, Pietro, additional, Puri, Ajit S, additional, Pero, Guglielmo, additional, Griessenauer, Christoph J, additional, Asadi, Hamed, additional, Siddiqui, Adnan, additional, Ducruet, Andrew F, additional, Albuquerque, Felipe C, additional, Du, Rose, additional, Kan, Peter, additional, Kalousek, Vladimir, additional, Lylyk, Pedro, additional, Boddu, Srikanth Reddy, additional, Stapleton, Christopher J, additional, Knopman, Jared, additional, Jabbour, Pascal, additional, Tjoumakaris, Stavropoula, additional, Clarençon, Frédéric, additional, Limbucci, Nicola, additional, Aziz-Sultan, Mohammad A, additional, Cuellar-Saenz, Hugo H, additional, Cognard, Christophe, additional, Patel, Aman B, additional, and Dmytriw, Adam A, additional

Published
2022
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21. Transradial Versus Transfemoral Access for Woven EndoBridge (WEB) Embolization of Intracranial Aneurysms: A Propensity-Score Matched Multicenter Study (P1-1.Virtual)

Author

Dibas, Mahmoud, primary, Adeeb, Nimer, additional, Diestro, Jose Danilo Bengzon, additional, Cuellar-Saenz, Hugo H., additional, Sweid, Ahmad, additional, Lay, Sovann V., additional, Guenego, Adrien, additional, Aslan, Asala, additional, Renieri, Leonardo, additional, Sundararajan, Sri Hari, additional, Saliou, Guillaume, additional, Möhlenbruch, Markus, additional, Regenhardt, Robert W., additional, Vranic, Justin E., additional, Lylyk, Ivan, additional, Foreman, Paul M., additional, Vachhani, Jay A., additional, Župančić, Vedran, additional, Hafeez, Muhammad U., additional, Rutledge, Caleb, additional, Waqas, Muhammad, additional, Tutino, Vincent M., additional, Rabinov, James D., additional, Ren, Yifan, additional, Schirmer, Clemens M., additional, Piano, Mariangela, additional, Kühn, Anna L., additional, Michelozzi, Caterina, additional, Elens, Stéphanie, additional, Starke, Robert M., additional, Hassan, Ameer E., additional, Salehani, Arsalaan, additional, Sporns, Peter, additional, Jones, Jesse, additional, Psychogios, Marios, additional, Spears, Julian, additional, Lubicz, Boris, additional, Panni, Pietro, additional, Puri, Ajit S., additional, Pero, Guglielmo, additional, Griessenauer, Christoph J., additional, Asadi, Hamed, additional, Stapleton, Christopher J., additional, Siddiqui, Adnan, additional, Ducruet, Andrew F., additional, Albuquerque, Felipe C., additional, Kan, Peter, additional, Kalousek, Vladimir, additional, Lylyk, Pedro, additional, Boddu, Srikanth, additional, Knopman, Jared, additional, Aziz-Sultan, Mohammad A., additional, Limbucci, Nicola, additional, Jabbour, Pascal, additional, Cognard, Christophe, additional, Patel, Aman B., additional, and Dmytriw, Adam A., additional

Published
2022
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22. The Woven EndoBridge (WEB) device for the treatment of Intracranial Aneurysms: A Decade of Lessons Learned and Changes in Practice from the WorldwideWEB Consortium (P1-1.Virtual)

Author

Dibas, Mahmoud, primary, Adeeb, Nimer, additional, Diestro, Jose Danilo Bengzon, additional, Cuellar-Saenz, Hugo H., additional, Sweid, Ahmad, additional, Lay, Sovann V., additional, Guenego, Adrien, additional, Aslan, Asala, additional, Renieri, Leonardo, additional, Sundararajan, Sri Hari, additional, Saliou, Guillaume, additional, Möhlenbruch, Markus, additional, Regenhardt, Robert W., additional, Vranic, Justin E., additional, Lylyk, Ivan, additional, Foreman, Paul M., additional, Vachhani, Jay A., additional, Župančić, Vedran, additional, Hafeez, Muhammad U., additional, Rutledge, Caleb, additional, Waqas, Muhammad, additional, Tutino, Vincent M., additional, Rabinov, James D., additional, Ren, Yifan, additional, Schirmer, Clemens M., additional, Piano, Mariangela, additional, Kühn, Anna L., additional, Michelozzi, Caterina, additional, Elens, Stéphanie, additional, Starke, Robert M., additional, Hassan, Ameer E., additional, Salehani, Arsalaan, additional, Sporns, Peter, additional, Jones, Jesse, additional, Psychogios, Marios, additional, Spears, Julian, additional, Lubicz, Boris, additional, Panni, Pietro, additional, Puri, Ajit S., additional, Pero, Guglielmo, additional, Griessenauer, Christoph J., additional, Asadi, Hamed, additional, Stapleton, Christopher J., additional, Siddiqui, Adnan, additional, Ducruet, Andrew F., additional, Albuquerque, Felipe C., additional, Kan, Peter, additional, Kalousek, Vladimir, additional, Lylyk, Pedro, additional, Boddu, Srikanth, additional, Knopman, Jared, additional, Aziz-Sultan, Mohammad A., additional, Limbucci, Nicola, additional, Jabbour, Pascal, additional, Cognard, Christophe, additional, Patel, Aman B., additional, and Dmytriw, Adam A., additional

Published
2022
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23. Comparing treatment outcomes of various intracranial bifurcation aneurysms locations using the Woven EndoBridge (WEB) device

Author

Adeeb, Nimer, primary, Dibas, Mahmoud, additional, Diestro, Jose Danilo Bengzon, additional, Phan, Kevin, additional, Cuellar-Saenz, Hugo H, additional, Sweid, Ahmad, additional, Lay, Sovann V, additional, Guenego, Adrien, additional, Aslan, Assala, additional, Renieri, Leonardo, additional, Sundararajan, Sri Hari, additional, Saliou, Guillaume, additional, Möhlenbruch, Markus, additional, Regenhardt, Robert W, additional, Vranic, Justin E, additional, Lylyk, Ivan, additional, Foreman, Paul M, additional, Vachhani, Jay A, additional, Župančić, Vedran, additional, Hafeez, Muhammad U, additional, Rutledge, Caleb, additional, Waqas, Muhammad, additional, Tutino, Vincent M, additional, Rabinov, James D, additional, Ren, Yifan, additional, Schirmer, Clemens M, additional, Piano, Mariangela, additional, Kuhn, Anna L, additional, Michelozzi, Caterina, additional, Elens, Stephanie, additional, Starke, Robert M, additional, Hassan, Ameer, additional, Salehani, Arsalaan, additional, Brehm, Alex, additional, MohammedAli, MajdEddin, additional, Jones, Jesse, additional, Psychogios, Marios, additional, Spears, Julian, additional, Lubicz, Boris, additional, Panni, Pietro, additional, Puri, Ajit S, additional, Pero, Guglielmo, additional, Griessenauer, Christoph J, additional, Asadi, Hamed, additional, Siddiqui, Adnan, additional, Ducruet, Andrew, additional, Albuquerque, Felipe C, additional, Du, Rose, additional, Kan, Peter, additional, Kalousek, Vladimir, additional, Lylyk, Pedro, additional, Stapleton, Christopher J, additional, Boddu, Srikanth, additional, Knopman, Jared, additional, Aziz-Sultan, Mohammad A, additional, Limbucci, Nicola, additional, Jabbour, Pascal, additional, Cognard, Christophe, additional, Patel, Aman B, additional, and Dmytriw, Adam A, additional

Published
2022
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24. Repeat Flow Diversion for Cerebral Aneurysms Failing Prior Flow Diversion: Safety and Feasibility From Multicenter Experience

Author

Salem, Mohamed M., primary, Sweid, Ahmad, additional, Kuhn, Anna L., additional, Dmytriw, Adam A., additional, Gomez-Paz, Santiago, additional, Maragkos, Georgios A., additional, Waqas, Muhammad, additional, Parra-Farinas, Carmen, additional, Salehani, Arsalaan, additional, Adeeb, Nimer, additional, Brouwer, Patrick, additional, Pickett, Gwynedd, additional, Ku, Jerry, additional, X.D. Yang, Victor, additional, Weill, Alain, additional, Radovanovic, Ivan, additional, Cognard, Christophe, additional, Spears, Julian, additional, Cuellar-Saenz, Hugo H., additional, Renieri, Leonardo, additional, Kan, Peter, additional, Limbucci, Nicola, additional, Mendes Pereira, Vitor, additional, Harrigan, Mark R., additional, Puri, Ajit S., additional, Levy, Elad I., additional, Moore, Justin M., additional, Ogilvy, Christopher S., additional, Marotta, Thomas R., additional, Jabbour, Pascal, additional, and Thomas, Ajith J., additional

Published
2022
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25. The Spectrum of Acute Cerebrovascular Disease in Patients with COVID-19

Author

Triay, Rachel, primary, Buchhanolla, Prabandh, additional, Gaudet, Alexas, additional, Winter, Victoria, additional, Gaudet, Alexandra, additional, Riel-Romero, Rosario Maria S., additional, Javalkar, Vijayakumar, additional, Kelley, Roger E., additional, Ansari, Junaid, additional, Faraji, Mehdi, additional, Gonzalez-Toledo, Eduardo, additional, Cuellar-Saenz, Hugo H., additional, Bailey, Steven, additional, Siddaiah, Harish, additional, and Gavins, Felicity N. E., additional

Published
2022
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26. International Study of Intracranial Aneurysm Treatment Using Woven EndoBridge: Results of the WorldWideWEB Consortium

Author

Dmytriw, Adam A., primary, Diestro, Jose Danilo Bengzon, additional, Dibas, Mahmoud, additional, Phan, Kevin, additional, Sweid, Ahmad, additional, Cuellar-Saenz, Hugo H., additional, Lay, Sovann V., additional, Guenego, Adrien, additional, Renieri, Leonardo, additional, Al Balushi, Ali, additional, Sundararajan, Sri Hari, additional, Carnevale, Joseph, additional, Saliou, Guillaume, additional, Möhlenbruch, Markus, additional, Vranic, Justin E., additional, Harker, Pablo, additional, Rabinov, James D., additional, Lylyk, Ivan, additional, Foreman, Paul M., additional, Vachhani, Jay A., additional, Župančić, Vedran, additional, Hafeez, Muhammad U., additional, Rutledge, Caleb, additional, Waqas, Muhammad, additional, Tutino, Vincent M., additional, Abbas, Rawad, additional, Inoue, Yasuaki, additional, Capirossi, Carolina, additional, Ren, Yifan, additional, Schirmer, Clemens M., additional, Piano, Mariangela, additional, Kühn, Anna Luisa, additional, Michelozzi, Caterina, additional, Elens, Stéphanie, additional, Regenhardt, Robert W., additional, Ghozy, Sherief, additional, Alotaibi, Naif M., additional, Tjoumakaris, Stavropoula, additional, Starke, Robert M., additional, Lubicz, Boris, additional, Panni, Pietro, additional, Puri, Ajit S., additional, Pero, Guglielmo, additional, Griessenauer, Christoph J., additional, Ulfert, Christian, additional, Asadi, Hamed, additional, Brooks, Mark, additional, Maingard, Julian, additional, Jhamb, Ashu, additional, Siddiqui, Adnan, additional, Ducruet, Andrew F., additional, Albuquerque, Felipe C., additional, Kan, Peter, additional, Kalousek, Vladimir, additional, Lylyk, Pedro, additional, Savardekar, Amey, additional, Boddu, Srikanth, additional, Knopman, Jared, additional, Limbucci, Nicola, additional, Chen, Karen S., additional, Aziz-Sultan, Mohammad A., additional, Stapleton, Christopher J., additional, Jabbour, Pascal, additional, Cognard, Christophe, additional, Patel, Aman B., additional, and Adeeb, Nimer, additional

Published
2022
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29. Intrasaccular flow disruption for ruptured aneurysms: an international multicenter study

Author

Diestro, Jose Danilo Bengzon, Dibas, Mahmoud, Adeeb, Nimer, Regenhardt, Robert W, Vranic, Justin E, Guenego, Adrien, Lay, Sovann V, Renieri, Leonardo, Al Balushi, Ali, Shotar, Eimad, Premat, Kevin, El Naamani, Kareem, Saliou, Guillaume, Mo¨hlenbruch, Markus A., Lylyk, Ivan, Foreman, Paul M, Vachhani, Jay A, Župančić, Vedran, Hafeez, Muhammad U, Rutledge, Caleb, Rai, Hamid, Tutino, Vincent M, Mirshani, Shervin, Ghozy, Sherief, Harker, Pablo, Alotaibi, Naif M, Rabinov, James D, Ren, Yifan, Schirmer, Clemens M, Goren, Oded, Piano, Mariangela, Kuhn, Anna Luisa, Michelozzi, Caterina, Elens, Stephanie, Starke, Robert M, Hassan, Ameer, Salehani, Arsalaan, Nguyen, Anh, Jones, Jesse, Psychogios, Marios, Spears, Julian, Parra-Fariñas, Carmen, Bres Bullrich, Maria, Mayich, Michael, Salem, Mohamed M, Burkhardt, Jan-Karl, Jankowitz, Brian T, Domingo, Ricardo A, Huynh, Thien, Tawk, Rabih, Ulfert, Christian, Lubicz, Boris, Panni, Pietro, Puri, Ajit S, Pero, Guglielmo, Griessenauer, Christoph J, Asadi, Hamed, Siddiqui, Adnan, Ducruet, Andrew F, Albuquerque, Felipe C, Du, Rose, Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Boddu, Srikanth Reddy, Stapleton, Christopher J, Knopman, Jared, Jabbour, Pascal, Tjoumakaris, Stavropoula, Clarencon, Frédéric, Limbucci, Nicola, Aziz-Sultan, Mohammad A, Cuellar-Saenz, Hugo H, Cognard, Christophe, Patel, Aman B, and Dmytriw, Adam A

Abstract

BackgroundThe Woven EndoBridge (WEB) device is a novel intrasaccular flow disruptor tailored for bifurcation aneurysms. We aim to describe the degree of aneurysm occlusion at the latest follow-up, and the rate of complications of aneurysms treated with the WEB device stratified according to rupture status.MethodsOur data were taken from the WorldWideWeb Consortium, an international multicenter cohort including patients treated with the WEB device. Aneurysms were classified into two groups: ruptured and unruptured. We compared clinical and radiologic outcomes of both groups. Propensity score matching (PSM) was done to match according to age, gender, bifurcation, location, prior treatment, neck, height, dome width, daughter sac, incorporated branch, pretreatment antiplatelets, and last imaging follow-up.ResultsThe study included 676 patients with 691 intracranial aneurysms (529 unruptured and 162 ruptured) treated with the WEB device. The PSM analysis had 55 pairs. In both the unmatched (85.8% vs 84.3%, p=0.692) and matched (94.4% vs 83.3%, p=0.066) cohorts there was no significant difference in the adequate occlusion rate at the last follow-up. Likewise, there were no significant differences in both ischemic and hemorrhagic complications between the two groups. There was no documented aneurysm rebleeding after WEB device implantation.ConclusionThere was no significant difference in both the radiologic outcomes and complications between unruptured and ruptured aneurysms. Our findings support the feasibility of treatment of ruptured aneurysms with the WEB device.

Published
2023
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30. Technical and clinical outcomes in concurrent multivessel occlusions treated with mechanical thrombectomy: insights from the STAR collaboration

Author

Saad, Hassan, Eshraghi, Sheila, Alawieh, Ali M, Akbik, Feras, Cawley, C Michael, Howard, Brian M, Ash, Makenna, Hsu, Alice, Pabaney, Aqueel, Maier, Ilko, Al Kasab, Sami, El Naamani, Kareem, Jabbour, Pascal, Kim, Joon-tae, Wolfe, Stacey Q, Rai, Ansaar, Starke, Robert M, Psychogios, Marios-Nikos, Shaban, Amir, Arthur, Adam S, Yoshimura, Shinichi, Fragata, Isabel, Cuellar-Saenz, Hugo H, Polifka, Adam J, Mascitelli, Justin, Osbun, Joshua W, Matouk, Charles, Park, Min S, Levitt, Michael R, Dumont, Travis M, Williamson, Richard, Spiotta, Alejandro M, and Grossberg, Jonathan A

Abstract

BackgroundEndovascular thrombectomy (EVT) has become the mainstay treatment for large vessel occlusion, with favorable safety and efficacy profile. However, the safety and efficacy of EVT in concurrent multi-territory occlusions (MTVOs) remains unclear.ObjectiveTo investigate the prevalence, clinical and technical outcomes of concurrent EVT for MTVOs.MethodsData were included from the Stroke Thrombectomy and Aneurysm Registry (STAR) with 32 stroke centers for EVT performed to treat bilateral anterior or concurrent anterior and posterior circulation occlusions between 2017 and 2021. Patients with MTVO were identified, and propensity score matching was used to compare this group with patients with occlusion in a single arterial territory.ResultsOf a total of 7723 patients who underwent EVT for acute ischemic stroke, 54 (0.7%) underwent EVT for MTVOs (mean age 69±12.5; female 50%). 28% had bilateral and 72% had anterior and posterior circulations occlusions. The rate of successful recanalization (Thrombolysis in Cerebral Infarction 2b/3), complications, modified Rankin score at 90 days, and mortality was not significantly different between the matched cohorts. Multivariate analysis confirmed that MTVOs were not associated with poor functional outcome, symptomatic intracranial hemorrhage, or longer procedure time.ConclusionCompared with EVT for single vessel occlusions, EVT in appropriately selected patients with MTVOs has a similar efficacy and safety profile.

Published
2023
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34. Assessment of Thrombectomy versus Combined Thrombolysis and Thrombectomy in Patients with Acute Ischemic Stroke and Medium Vessel Occlusion

Author

Dmytriw, Adam A., Ghozy, Sherief, Salim, Hamza Adel, Musmar, Basel, Siegler, James E., Kobeissi, Hassan, Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Regenhardt, Robert W., Cancelliere, Nicole M., El Naamani, Kareem, Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Kühn, Anna Luisa, Puri, Ajit S., Dyzmann, Christian, Kan, Peter T., Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Marotta, Thomas R., Stapleton, Christopher J., Rabinov, James D., Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard L. L., Tan, Benjamin Y. Q., Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Adeeb, Nimer, Cuellar-Saenz, Hugo H., Tjoumakaris, Stavropoula I., Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., Möhlenbruch, Markus A., Jesser, Jessica, Costalat, Vincent, Schiphorst, Adrien ter, Yedavalli, Vivek, Harker, Pablo, Chervak, Lina M., Aziz, Yasmin, Gory, Benjamin, Stracke, Christian Paul, Hecker, Constantin, Kadirvel, Ramanathan, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Thomas, Ajith J., Hsieh, Cheng-Yang, Liebeskind, David S., Radu, Răzvan Alexandru, Alexandre, Andrea M., Tancredi, Illario, Faizy, Tobias D., Fahed, Robert, Weyland, Charlotte S., Lubicz, Boris, Patel, Aman B., Pereira, Vitor Mendes, and Guenego, Adrien

Abstract

This international multicenter study found that adjunctive intravenous thrombolysis may not provide benefit to mechanical thrombectomy in patients with acute ischemic stroke caused by distal and medium vessel occlusion.

Published
2024
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35. Implications of the use of mechanical thrombectomy on outcome in large vessel occlusion following the 2015 landmark trials.

Author

Kuybu, Okkes, Javalkar, Vijayakumar, Amireh, Abdallah, Kaur, Arshpreet, Kelley, Roger E., Cuellar-Saenz, Hugo H., and Sharma, Pankaj

Subjects
STROKE treatment, HOSPITALS, BLOOD vessels, CEREBRAL ischemia, CHI-squared test, DISABILITY evaluation, INTRAVENOUS therapy, THROMBOLYTIC therapy, VEIN surgery, LOGISTIC regression analysis, TREATMENT effectiveness, DESCRIPTIVE statistics, HOSPITAL mortality, THROMBECTOMY
Abstract

Background The effectiveness of mechanical thrombectomy (MT) was demonstrated in five landmark trials published in2015.Mechanical thrombectomy is now standard of care for acute ischemic stroke and has been growing in popularity after publication of landmark trials. Objective To analyze outcomes and trends of the use of MT and intravenous thrombolysis (IVT) in patients with acute ischemic stroke in US hospitals before and after publication of these trials. Methods Patients discharged with a diagnosis of ischemic stroke between 2012 to 2017 were diagnosed using ICD codes from the National Inpatient Sample. Thereafter, patients given acute stroke treatment were identified using the corresponding procedure codes for IVT and MT. The primary clinical outcomes of in-hospital mortality and disability were then compared between two time periods: 2012-2014 (pre-landmark trials) and 2015-2017 (post-landmark trials). Binary logistic regression and X² tests were used for statistical analysis. Results A total of 57 675 patients (median age 68.9 years (range 18-90), 50.1% female) were identified with acute procedures. Of these patients, 57.6% were from the post-landmark trials time period. Despite an increased number of cases, the rate of IVT decreased from 84.3% to 75.9% and the rate of IVT+MT decreased from 7.1% to 6.3%. After publication of the pivotal trials in 2015, the rates of MT increased from 8.7% to 17.8%. Significant reductions of in-hospital mortality (7.1% vs 8.7%, p<0.001) and disability (64% vs 66.2%, p<0.001) were noted. Conclusion The analysis showed a significant increase in the proportion of patients receiving MT after 2015. This has translated into reduction of in-hospital mortality and improvement in disability. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Comparison of pipeline embolization device and flow redirection endoluminal device in the treatment of intracranial aneurysms: A systematic review and meta-analysis

Author

Musmar, Basel, Orscelik, Atakan, Salim, Hamza, Musmar, Fares, Adeeb, Nimer, Naamani, Kareem El, Essibayi, Muhammed Amir, Spellicy, Samantha, Abdelgadir, Jihad, Dmytriw, Adam A., Patel, Aman B., Pereira, Vitor Mendes, Cuellar-Saenz, Hugo H., Guthikonda, Bharat, Zomorodi, Ali, Jabbour, Pascal, and Hasan, David

Abstract

Background Advancements in flow diversion technology have revolutionized the treatment of intracranial aneurysms. The pipeline embolization device (PED) and the flow redirection endoluminal device (FRED) have emerged as prominent tools in this field. This study aims to compare the safety and efficacy profiles of PED and FRED in the treatment of intracranial aneurysms.Methods Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive literature search was conducted across PubMed, Web of Science, and Scopus databases. Studies comparing PED and FRED were included and data extraction focused on study characteristics, patient demographics, and clinical and radiological outcomes. Primary outcomes were favorable outcomes, described as modified Rankin scale (mRS) 0–2 score, and complete/near-complete occlusion, while secondary outcomes included retreatment rate and thromboembolic and hemorrhagic complications.Results Five studies, comprising 1238 patients, were included. No significant differences were found between PED and FRED in terms of complete occlusion at 6 months and 1 year, complete/near-complete occlusion at the last follow up, retreatment rates, and thromboembolic, in-stent thrombosis and hemorrhagic complications. However, FRED was significantly associated with higher favorable outcomes compared to PED (odds ratio: 0.37; confidence interval: 0.17 to 0.81; p = 0.01).Conclusion This study showed that both PED and FRED had comparable rates of complete occlusion, retreatment and complications, and FRED also demonstrated a higher likelihood of achieving favorable outcomes. The study underscores the need for further research with larger cohorts and longer follow up to consolidate these findings.

Published
2024
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37. Creation of a predictive calculator to determine adequacy of occlusion of the woven endobridge (WEB) device in intracranial aneurysms—A retrospective analysis of the WorldWide WEB Consortium database

Author

Musmar, Basel, Adeeb, Nimer, Gendreau, Julian, Horowitz, Melanie Alfonzo, Salim, Hamza Adel, Sanmugananthan, Praveen, Aslan, Assala, Brown, Nolan J, Cancelliere, Nicole M, McLellan, Rachel M, Algin, Oktay, Ghozy, Sherief, Dibas, Mahmoud, Orscelik, Atakan, Senol, Yigit Can, Lay, Sovann V, Guenego, Adrien, Renieri, Leonardo, Carnevale, Joseph, Saliou, Guillaume, Mastorakos, Panagiotis, El Naamani, Kareem, Shotar, Eimad, Premat, Kevin, Möhlenbruch, Markus, Kral, Michael, Doron, Omer, Chung, Charlotte, Salem, Mohamed M, Lylyk, Ivan, Foreman, Paul M, Vachhani, Jay A, Shaikh, Hamza, Župančić, Vedran, Hafeez, Muhammad U, Catapano, Joshua, Waqas, Muhammad, Tutino, Vincent M, Gokhan, Yuce, Imamoglu, Cetin, Bayrak, Ahmet, Rabinov, James D, Ren, Yifan, Schirmer, Clemens M, Piano, Mariangela, Kühn, Anna L, Michelozzi, Caterina, Elens, Stéphanie, Starke, Robert M, Hassan, Ameer E, Ogilvie, Mark, Nguyen, Anh, Jones, Jesse, Brinjikji, Waleed, Nawka, Marie T, Psychogios, Marios, Ulfert, Christian, Bengzon Diestro, Jose Danilo, Pukenas, Bryan, Burkhardt, Jan-Karl, Huynh, Thien, Martinez-Gutierrez, Juan Carlos, Essibayi, Muhammed Amir, Sheth, Sunil A, Spiegel, Gary, Tawk, Rabih, Lubicz, Boris, Panni, Pietro, Puri, Ajit S, Pero, Guglielmo, Nossek, Erez, Raz, Eytan, Killer-Oberfalzer, Monika, Griessenauer, Christoph J, Asadi, Hamed, Siddiqui, Adnan, Brook, Allan L, Altschul, David, Ducruet, Andrew F, Albuquerque, Felipe C, Regenhardt, Robert W, Stapleton, Christopher J, Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Boddu, Srikanth, Knopman, Jared, Aziz-Sultan, Mohammad A, Tjoumakaris, Stavropoula I, Clarençon, Frédéric, Limbucci, Nicola, Bydon, Mohamad, Hasan, David, Cuellar-Saenz, Hugo H, Jabbour, Pascal M, Pereira, Vitor Mendes, Patel, Aman B, and Dmytriw, Adam A

Abstract

Background Endovascular treatment with the woven endobridge (WEB) device has been widely utilized for managing intracranial aneurysms. However, predicting the probability of achieving adequate occlusion (Raymond–Roy classification 1 or 2) remains challenging.Objective Our study sought to develop and validate a predictive calculator for adequate occlusion using the WEB device via data from a large multi-institutional retrospective cohort.Methods We used data from the WorldWide WEB Consortium, encompassing 356 patients from 30 centers across North America, South America, and Europe. Bivariate and multivariate regression analyses were performed on a variety of demographic and clinical factors, from which predictive factors were selected. Calibration and validation were conducted, with variance inflation factor (VIF) parameters checked for collinearity.Results A total of 356 patients were included: 124 (34.8%) were male, 108 (30.3%) were elderly (≥65 years), and 118 (33.1%) were current smokers. Mean maximum aneurysm diameter was 7.09 mm (SD 2.71), with 112 (31.5%) having a daughter sac. In the multivariate regression, increasing aneurysm neck size (OR 0.706 [95% CI: 0.535–0.929], p= 0.13) and partial aneurysm thrombosis (OR 0.135 [95% CI: 0.024–0.681], p= 0.016) were found to be the only statistically significant variables associated with poorer likelihood of achieving occlusion. The predictive calculator shows a c-statistic of 0.744. Hosmer–Lemeshow goodness-of-fit test indicated a satisfactory model fit with a p-value of 0.431. The calculator is available at: https://neurodx.shinyapps.io/WEBDEVICE/.Conclusion The predictive calculator offers a substantial contribution to the clinical toolkit for estimating the likelihood of adequate intracranial aneurysm occlusion by WEB device embolization.

Published
2024
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38. Incidence and clinical outcomes of perforations during mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke: A retrospective, multicenter, and multinational study

Author

Dmytriw, Adam A, Musmar, Basel, Salim, Hamza, Ghozy, Sherief, Siegler, James E, Kobeissi, Hassan, Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N, Heit, Jeremy J, Regenhardt, Robert W, Cancelliere, Nicole M, Bernstock, Joshua D, Naamani, Kareem El, Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Kühn, Anna Luisa, Puri, Ajit S, Dyzmann, Christian, Kan, Peter T, Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Marotta, Thomas R, Stapleton, Christopher J, Rabinov, James D, Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard LL, Tan, Benjamin YQ, Gopinathan, Anil, Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Chervak, Lina, Vagal, Achala, Adeeb, Nimer, Cuellar-Saenz, Hugo H, Tjoumakaris, Stavropoula I, Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R, Möhlenbruch, Markus A, Jesser, Jessica, Costalat, Vincent, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Aziz, Yasmin, Gory, Benjamin, Stracke, Christian Paul, Hecker, Constantin, Kadirvel, Ramanathan, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J, Thomas, Ajith J, Hsieh, Cheng-Yang, Liebeskind, David S, Alexandru Radu, Răzvan, Alexandre, Andrea M, Tancredi, Illario, Faizy, Tobias D, Fahed, Robert, Weyland, Charlotte, Lubicz, Boris, Patel, Aman B, Pereira, Vitor Mendes, and Guenego, Adrien

Abstract

Background: Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium vessel occlusion (MeVO) remain less explored. This multicenter, retrospective study aims to investigate the incidence and clinical outcomes of vessel perforations (confirmed by extravasation during an angiographic series) during MT for AIS caused by MeVO.Methods: Data were collected from 37 academic centers across North America, Asia, and Europe between September 2017 and July 2021. A total of 1373 AIS patients with MeVO underwent MT. Baseline characteristics, procedural details, and clinical outcomes were analyzed.Results: The incidence of vessel perforation was 4.8% (66/1373). Notably, our analysis indicates variations in perforation rates across different arterial segments: 8.9% in M3 segments, 4.3% in M2 segments, and 8.3% in A2 segments (p= 0.612). Patients with perforation had significantly worse outcomes, with lower rates of favorable angiographic outcomes (TICI 2c-3: 23% vs 58.9%, p< 0.001; TICI 2b-3: 56.5% vs 88.3%, p< 0.001). Functional outcomes were also worse in the perforation group (mRS 0–1 at 3 months: 22.7% vs 36.6%, p= 0.031; mRS 0–2 at 3 months: 28.8% vs 53.9%, p< 0.001). Mortality was higher in the perforation group (30.3% vs 16.8%, p= 0.008).Conclusion: This study reveals that while the occurrence of vessel perforation in MT for AIS due to MeVO is relatively rare, it is associated with poor functional outcomes and higher mortality. The findings highlight the need for increased caution and specialized training in performing MT for MeVO. Further prospective research is required for risk mitigation strategies.

Published
2024
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39. Morphological characteristics of brain aneurysms among age groups

Author

Sanchez, Sebastian, Essibayi, Muhammed Amir, Hickerson, Meredith, Ojeda, Diego J, Kasab, Sami Al, Yoshimura, Shinichi, Jabbour, Pascal M., Mascitelli, Justin, Levitt, Michael R., Cuellar-Saenz, Hugo H., Brinjikji, Waleed, Spiotta, Alejandro M., Shaban, Amir, and Samaniego, Edgar A

Abstract

Background Patient's age is an important factor in determining the risk of aneurysm rupture. However, there is limited data on how aneurysm morphology differs among age groups. We studied morphological characteristics of brain aneurysms among age groups in a large cohort.Methods Aneurysms from the Stroke Thrombectomy and Aneurysm Registry (STAR) were analyzed. The following parameters were included: location, size, neck, width, height, aspect ratio, and regular versus irregular morphology. The risk of rupture presentation was estimated using logistic regression.Results A total of 1407 unruptured and 607 ruptured saccular aneurysms were included. The most common locations of ruptured aneurysms in patients younger than 70 years-old were the middle cerebral artery (MCA) and the anterior communicating artery (ACOM). The most common location of ruptured aneurysms in patients older than 70 years-old were the posterior communicating artery (PCOM) and ACOM. The size of unruptured aneurysms increased with age (p < .001). Conversely, the size of ruptured aneurysms was similar among age groups (p = .142). Unruptured and ruptured aneurysms became more irregular at presentation with older age (p < .001 and p .025, respectively). Irregular morphology and location were associated with rupture status across all age groups in multivariate regression.Conclusions Younger patients have small unruptured and ruptured aneurysms, and ruptured aneurysms are mostly located in the MCA and ACOM. Older patients have larger and more irregular unruptured aneurysms, and ruptured aneurysms are mostly located in the PCOM and ACOM. An irregular morphology increases the risk of rupture in all age groups.

Published
2024
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41. Defining ideal middle cerebral artery bifurcation aneurysm size for Woven EndoBridge embolization.

Author

Adeeb N, Musmar B, Salim HA, Aslan A, Alla A, Cancelliere NM, McLellan RM, Algin O, Ghozy S, Dibas M, Lay SV, Guenego A, Renieri L, Carnevale J, Saliou G, Mastorakos P, Naamani KE, Shotar E, Premat K, Möhlenbruch M, Kral M, Doron O, Chung C, Salem MM, Lylyk I, Foreman PM, Vachhani JA, Shaikh H, Župančić V, Hafeez MU, Catapano JS, Waqas M, Tutino VM, Ibrahim MK, Mohammed MA, Ozates MO, Ayberk G, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan A, Ogilvie M, Nguyen A, Jones J, Brinjikji W, Nawka MT, Psychogios M, Ulfert C, Diestro JDB, Pukenas B, Burkhardt JK, Domingo RA, Huynh T, Martinez-Gutierrez JC, Essibayi MA, Sheth SA, Spiegel G, Tawk RG, Lubicz B, Panni P, Puri AS, Pero G, Nossek E, Raz E, Killer-Oberfalzer M, Griessenauer CJ, Asadi H, Siddiqui A, Brook AL, Altschul D, Ducruet AF, Albuquerque FC, Regenhardt RW, Stapleton CJ, Kan P, Kalousek V, Lylyk P, Boddu S, Knopman J, Aziz-Sultan MA, Tjoumakaris SI, Clarençon F, Limbucci N, Cuellar-Saenz HH, Jabbour PM, Mendes Pereira V, Patel AB, and Dmytriw AA

Abstract

Objective: The Woven EndoBridge (WEB) device was approved to treat wide-necked bifurcation aneurysms. The device is designed as an intrasaccular flow disruptor covering aneurysm widths up to 10 mm. Although prior studies combined all aneurysm sizes, it is known that aneurysms behave differently in response to endovascular treatment based on their size. Therefore, the authors' objective was to identify ideal middle cerebral artery (MCA) aneurysm width and neck sizes most suitable for WEB treatment., Methods: The WorldWideWEB consortium is a large multicenter retrospective database that analyzes intracranial aneurysms treated with the WEB device. In this study, all unruptured MCA bifurcation aneurysms with available measurements were included. Cutoff values based on aneurysm width and neck in relation to aneurysm occlusion status were measured using the receiver operating characteristic (ROC) curve. Propensity score matching (PSM) was then used to compare treatment outcomes between aneurysms smaller and larger than the cutoff value for both width and neck size., Results: The ideal cutoff values for MCA bifurcation aneurysm width and neck were 6.1 mm and 4.6 mm, respectively. On PSM, 87 matched pairs were compared based on width size (≤ 6.1 mm and > 6.1 mm), and 77 matched pairs were compared based on neck size (≤ 4.6 mm and > 4.6 mm). There was a significant difference in adequate aneurysm occlusion between aneurysms smaller and larger than those cutoff values for both widths (93% vs 76%, p = 0.0017) and neck sizes (90% vs 70%, p = 0.0026). The retreatment rate was also significantly higher for larger aneurysms in both parameters., Conclusions: This study shows that MCA bifurcation aneurysms ≤ 6.1 mm in width and ≤ 4.6 mm in neck size are significantly better candidates for WEB treatment, leading to improved occlusion status and reduced retreatment rate, which are important considerations when using WEB devices.

Published
2024
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42. Treatment of large intracranial aneurysms using the Woven EndoBridge (WEB): a propensity score-matched analysis.

Author

Musmar B, Salim HA, Adeeb N, Aslan A, Aljeradat B, Diestro JDB, McLellan RM, Algin O, Ghozy S, Dibas M, Lay SV, Guenego A, Renieri L, Cancelliere NM, Carnevale J, Saliou G, Mastorakos P, El Naamani K, Shotar E, Premat K, Möhlenbruch M, Kral M, Vranic JE, Chung C, Salem MM, Lylyk I, Foreman PM, Vachhani JA, Shaikh H, Župančić V, Hafeez MU, Catapano J, Waqas M, Tutino VM, Ibrahim MK, Mohammed MA, Ozates MO, Ayberk G, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan A, Ogilvie M, Nguyen A, Jones J, Brinjikji W, Nawka MT, Psychogios M, Ulfert C, Spears J, Jankowitz BT, Burkhardt JK, Domingo RA, Huynh T, Martinez-Gutierrez JC, Essibayi MA, Sheth SA, Spiegel G, Tawk R, Lubicz B, Panni P, Puri AS, Pero G, Nossek E, Raz E, Killer-Oberfalzer M, Griessenauer CJ, Asadi H, Siddiqui A, Brook A, Altschul D, Ducruet AF, Albuquerque FC, Regenhardt RW, Stapleton CJ, Kan P, Kalousek V, Lylyk P, Boddu S, Knopman J, Aziz-Sultan MA, Tjoumakaris SI, Clarençon F, Limbucci N, Cuellar-Saenz HH, Jabbour PM, Pereira VM, Patel AB, and Dmytriw AA

Subjects
Humans, Male, Female, Middle Aged, Retrospective Studies, Aged, Treatment Outcome, Adult, Embolization, Therapeutic methods, Intracranial Aneurysm therapy, Intracranial Aneurysm surgery, Propensity Score, Endovascular Procedures methods
Abstract

The Woven EndoBridge (WEB) device is primarily used for treating wide-neck intracranial bifurcation aneurysms under 10 mm. Limited data exists on its efficacy for large aneurysms. We aim to assess angiographic and clinical outcomes of the WEB device in treating large versus small aneurysms. We conducted a retrospective review of the WorldWide WEB Consortium database, from 2011 to 2022, across 30 academic institutions globally. Propensity score matching (PSM) was employed to compare small and large aneurysms on baseline characteristics. A total of 898 patients were included. There was no significant difference observed in clinical presentations, smoking status, pretreatment mRS, presence of multiple aneurysms, bifurcation location, or prior treatment between the two groups. After PSM, 302 matched pairs showed significantly lower last follow-up adequate occlusion rates (81% vs 90%, p = 0.006) and higher retreatment rates (12% vs 3.6%, p < 0.001) in the large aneurysm group. These findings may inform treatment decisions and patient counseling. Future studies are needed to further explore this area., (© 2024. The Author(s).)

Published
2024
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43. Predictors of Aneurysm Obliteration in Patients Treated with the WEB Device: Results of a Multicenter Retrospective Study.

Author

Mastorakos P, Naamani KE, Adeeb N, Lan M, Castiglione J, Khanna O, Ghosh R, Bengzon Diestro JD, Dibas M, McLellan RM, Algin O, Ghozy S, Cancelliere NM, Aslan A, Cuellar-Saenz HH, Lay SV, Guenego A, Renieri L, Carnevale J, Saliou G, Shotar E, Premat K, Möhlenbruch M, Kral M, Vranic JE, Chung C, Salem MM, Lylyk I, Foreman PM, Vachhani JA, Shaikh H, Župančić V, Hafeez MU, Catapano J, Waqas M, Tutino VM, Ibrahim MK, Mohammed MA, Rabinov JD, Ren Y, Schirmer CM, Piano M, Bullrich MB, Mayich M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan AE, Ogilvie M, Nguyen A, Jones J, Brinjikji W, Psychogios M, Ulfert C, Spears J, Jankowitz BT, Burkhardt JK, Domingo RA, Huynh T, Tawk RG, Lubicz B, Nawka MT, Panni P, Puri AS, Pero G, Nossek E, Raz E, Killer-Oberpfalzer M, Ozates MO, Ayberk G, Regenhardt RW, Griessenauer CJ, Asadi H, Siddiqui A, Ducruet AF, Albuquerque FC, Patel NJ, Stapleton CJ, Kan P, Kalousek V, Lylyk P, Boddu S, Knopman J, Aziz-Sultan MA, Clarençon F, Limbucci N, Zanaty M, Martinez-Gutierrez JC, Sheth S, Spiegel G, Abbas R, Amllay A, Tjoumakaris SI, Gooch MR, Herial NA, Rosenwasser RH, Zarzour H, Schmidt RF, Pereira VM, Patel AB, Jabbour PM, and Dmytriw AA

Subjects
Humans, Male, Female, Middle Aged, Retrospective Studies, Treatment Outcome, Aged, Risk Factors, Intracranial Aneurysm diagnostic imaging, Intracranial Aneurysm therapy, Intracranial Aneurysm surgery, Embolization, Therapeutic instrumentation, Embolization, Therapeutic methods
Abstract

Background and Purpose: Despite the numerous studies evaluating the occlusion rates of aneurysms following WEB embolization, there are limited studies identifying predictors of occlusion. Our purpose was to identify predictors of aneurysm occlusion and the need for retreatment., Materials and Methods: This is a review of a prospectively maintained database across 30 academic institutions. We included patients with previously untreated cerebral aneurysms embolized using the WEB who had available intraprocedural data and long-term follow-up., Results: We studied 763 patients with a mean age of 59.9 (SD, 11.7) years. Complete aneurysm occlusion was observed in 212/726 (29.2%) cases, and contrast stasis was observed in 485/537 (90.3%) of nonoccluded aneurysms. At the final follow-up, complete occlusion was achieved in 497/763 (65.1%) patients, and retreatment was required for 56/763 (7.3%) patients. On multivariable analysis, history of smoking, maximal aneurysm diameter, and the presence of an aneurysm wall branch were negative predictors of complete occlusion (OR, 0.5, 0.8, and 0.4, respectively). Maximal aneurysm diameter, the presence of an aneurysm wall branch, posterior circulation location, and male sex increase the chances of retreatment (OR, 1.2, 3.8, 3.0, and 2.3 respectively). Intraprocedural occlusion resulted in a 3-fold increase in the long-term occlusion rate and a 5-fold decrease in the retreatment rate ( P < .001), offering a specificity of 87% and a positive predictive value of 85% for long-term occlusion., Conclusions: Intraprocedural occlusion can be used to predict the chance of long-term aneurysm occlusion and the need for retreatment after embolization with a WEB device. Smoking, aneurysm size, and the presence of an aneurysm wall branch are associated with decreased chances of successful treatment., (© 2024 by American Journal of Neuroradiology.)

Published
2024
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44. Association of preprocedural antiplatelet use with decreased thromboembolic complications for intracranial aneurysms undergoing intrasaccular flow disruption.

Author

Diestro JDB, Adeeb N, Musmar B, Salim H, Aslan A, Cancelliere NM, McLellan RM, Algin O, Ghozy S, Lay SV, Guenego A, Renieri L, Carnevale J, Saliou G, Mastorakos P, El Naamani K, Shotar E, Premat K, Möhlenbruch M, Kral M, Bernstock JD, Doron O, Chung C, Salem MM, Lylyk I, Foreman PM, Vachhani JA, Shaikh H, Župančić V, Hafeez MU, Catapano J, Waqas M, Ibrahim MK, Mohammed MA, Imamoglu C, Bayrak A, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan AE, Ogilvie M, Nguyen A, Jones J, Brinjikji W, Nawka MT, Psychogios M, Ulfert C, Pukenas B, Burkhardt JK, Huynh T, Martinez-Gutierrez JC, Essibayi MA, Sheth SA, Spiegel G, Tawk RG, Lubicz B, Panni P, Puri AS, Pero G, Nossek E, Raz E, Killer-Oberpfalzer M, Griessenauer CJ, Asadi H, Siddiqui A, Brook AL, Altschul D, Spears J, Marotta TR, Ducruet AF, Albuquerque FC, Regenhardt RW, Stapleton CJ, Kan P, Kalousek V, Lylyk P, Boddu S, Knopman J, Aziz-Sultan MA, Tjoumakaris SI, Jabbour PM, Clarençon F, Limbucci N, Cuellar-Saenz HH, Mendes Pereira V, Patel AB, and Dmytriw AA

Subjects
Humans, Male, Female, Retrospective Studies, Middle Aged, Aged, Postoperative Complications prevention & control, Postoperative Complications etiology, Postoperative Complications epidemiology, Adult, Intracranial Aneurysm, Platelet Aggregation Inhibitors administration & dosage, Platelet Aggregation Inhibitors therapeutic use, Thromboembolism prevention & control, Thromboembolism etiology, Endovascular Procedures methods
Abstract

Objective: This study was conducted to investigate the impact of antiplatelet administration in the periprocedural period on the occurrence of thromboembolic complications (TECs) in patients undergoing treatment using the Woven EndoBridge (WEB) device for intracranial wide-necked bifurcation aneurysms. The primary objective was to assess whether the use of antiplatelets in the pre- and postprocedural phases reduces the likelihood of developing TECs, considering various covariates., Methods: A retrospective multicenter observational study was conducted within the WorldWideWEB Consortium and comprised 38 academic centers with endovascular treatment capabilities. Univariable and multivariable logistic regression analyses were performed to determine the association between antiplatelet use and TECs, adjusting for covariates. Missing predictor data were addressed using multiple imputation., Results: The study comprised two cohorts: one addressing general thromboembolic events and consisting of 1412 patients, among whom 103 experienced TECs, and another focusing on symptomatic thromboembolic events and comprising 1395 patients, of whom 50 experienced symptomatic TECs. Preprocedural antiplatelet use was associated with a reduced likelihood of overall TECs (OR 0.32, 95% CI 0.19-0.53, p < 0.001) and symptomatic TECs (OR 0.49, 95% CI 0.25-0.95, p = 0.036), whereas postprocedural antiplatelet use showed no significant association with TECs. The study also revealed additional predictors of TECs, including stent use (overall: OR 4.96, 95% CI 2.38-10.3, p < 0.001; symptomatic: OR 3.24, 95% CI 1.26-8.36, p = 0.015), WEB single-layer sphere (SLS) type (overall: OR 0.18, 95% CI 0.04-0.74, p = 0.017), and posterior circulation aneurysm location (symptomatic: OR 18.43, 95% CI 1.48-230, p = 0.024)., Conclusions: The findings of this study suggest that the preprocedural administration of antiplatelets is associated with a reduced likelihood of TECs in patients undergoing treatment with the WEB device for wide-necked bifurcation aneurysms. However, postprocedural antiplatelet use did not show a significant impact on TEC occurrence.

Published
2024
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45. Stent-assisted Woven EndoBridge device for the treatment of intracranial aneurysms: an international multicenter study.

Author

Diestro JDB, Dibas M, Adeeb N, Regenhardt RW, Vranic JE, Guenego A, Lay SV, Renieri L, Balushi AA, Shotar E, Premat K, Namaani KE, Saliou G, Möhlenbruch MA, Lylyk I, Foreman PM, Vachhani JA, Župančić V, Hafeez MU, Rutledge C, Rai H, Tutino VM, Mirshahi S, Ghozy S, Harker P, Alotaibi NM, Rabinov JD, Ren Y, Schirmer CM, Goren O, Piano M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan AE, Salehani A, Nguyen A, Jones J, Psychogios M, Spears J, Marotta T, Pereira V, Parra-Fariñas C, Bres-Bullrich M, Mayich M, Salem MM, Burkhardt JK, Jankowitz BT, Domingo RA, Huynh T, Tawk R, Ulfert C, Lubicz B, Panni P, Puri AS, Pero G, Griessenauer CJ, Asadi H, Siddiqui A, Ducruet AF, Albuquerque FC, Patel N, Kan P, Kalousek V, Lylyk P, Boddu S, Stapleton CJ, Knopman J, Jabbour P, Tjoumakaris S, Clarençon F, Limbucci N, Aziz-Sultan MA, Cuellar-Saenz HH, Cognard C, Patel AB, and Dmytriw AA

Subjects
Humans, Treatment Outcome, Retrospective Studies, Stents, Intracranial Aneurysm diagnostic imaging, Intracranial Aneurysm surgery, Embolization, Therapeutic, Endovascular Procedures
Abstract

Objective: The Woven EndoBridge (WEB) device is an intrasaccular flow disruptor designed for wide-necked bifurcation aneurysms. These aneurysms may require the use of a concomitant stent. The objective of this study was to determine the clinical and radiological outcomes of patients undergoing stent-assisted WEB treatment. In addition, the authors also sought to determine the predictors of a concomitant stent in aneurysms treated with the WEB device., Methods: The data for this study were taken from the WorldWideWEB Consortium, an international multicenter cohort including patients treated with the WEB device. Aneurysms were classified into two groups based on treatment: stent-assisted WEB and WEB device alone. The authors compared clinical and radiological outcomes of both groups. Univariable and multivariable binary logistic regression analyses were performed to determine factors that predispose to stent use., Results: The study included 691 intracranial aneurysms (31 with stents and 660 without stents) treated with the WEB device. The adequate occlusion status did not differ between the two groups at the latest follow-up (83.3% vs 85.6%, p = 0.915). Patients who underwent stenting had more thromboembolic (32.3% vs 6.5%, p < 0.001) and procedural (16.1% vs 3.0%, p < 0.001) complications. Aneurysms treated with a concomitant stent had wider necks, greater heights, and lower dome-to-neck ratios. Increasing neck size was the only significant predictor for stent use., Conclusions: This study demonstrates that there is no difference in the degree of aneurysm occlusion between the two groups; however, complications were more frequent in the stent group. In addition, a wider aneurysm neck predisposes to stent assistance in WEB-treated aneurysms.

Published
2023
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