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Simple Summary: Models of species distribution allow us to learn how different environmental factors determine where species are found. Our study focused on the Chilean dolphin in Seno Skyring, Chilean Patagonia. We used three different methods to predict where these dolphins are likely to be found, based on environmental data like water temperature, salinity, and proximity to the coast, as well as human activities like fish farming. We found that dolphins are most commonly found within six kilometers of the coast, in areas with many fish farms. This suggests that the dolphins may be attracted to areas near fish farms. Understanding these patterns is crucial for developing strategies to protect the endangered Chilean dolphin, especially given the large fish-farming industry in Chile. Our research highlights the need for more knowledge and comprehensive conservation efforts to ensure the dolphins' long-term survival. Species distribution modeling helps understand how environmental factors influence species distribution, creating profiles to predict presence in unexplored areas and assess ecological impacts. This study examined the habitat use and population ecology of the Chilean dolphin in Seno Skyring, Chilean Patagonia. We used three models—random forest (RF), generalized linear model (GLM), and artificial neural network (ANN)—to predict dolphin distribution based on environmental and biotic data like water temperature, salinity, and fish farm density. Our research has determined that the RF model is the most precise tool for predicting the habitat preferences of Chilean dolphins. The results indicate that these dolphins are primarily located within six kilometers of the coast, strongly correlating with areas featuring numerous fish farms, sheltered waters close to the shore with river inputs, and shallow productive zones. This suggests a potential association between dolphin presence and fish-farming activities. These findings can guide targeted conservation measures, such as regulating fish-farming practices and protecting vital coastal areas to improve the survival prospects of the Chilean dolphin. Given the extensive fish-farming industry in Chile, this research highlights the need for greater knowledge and comprehensive conservation efforts to ensure the species' long-term survival. By understanding and mitigating the impacts of fish farming and other human activities, we can better protect the habitat and well-being of Chilean dolphins. [ABSTRACT FROM AUTHOR]