1. High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership.
- Author
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Carlucci, Philip M, Li, Jessica, Fava, Andrea, Deonaraine, Kristina K, Wofsy, David, James, Judith A, Putterman, Chaim, Diamond, Betty, Davidson, Anne, Fine, Derek M, Monroy-Trujillo, Jose, Atta, Mohamed G, DeJager, Wade, Guthridge, Joel M, Haag, Kristin, Rao, Deepak A, Brenner, Michael B, Lederer, James A, Apruzzese, William, Belmont, H Michael, Izmirly, Peter M, Zaminski, Devyn, Wu, Ming, Connery, Sean, Payan-Schober, Fernanda, Furie, Richard, Dall’Era, Maria, Cho, Kerry, Kamen, Diane, Kalunian, Kenneth, Anolik, Jennifer, Barnas, Jennifer, Ishimori, Mariko, Weisman, Michael H, Goff, Jennifer, Dunn, Patrick J, Raychaudhuri, Soumya, Zhang, Fan, Korsunsky, Ilya, Nathan, Aparna, Mears, Joseph, Ishigaki, Kazuyoshi, Xiao, Qian, Millard, Nghia, Weinand, Kathryn, Sakaue, Saori, Utz, PJ, Mao, Rong, Robinson, Bill, Maecker, Holden, Macwana, Susan, Bridges, S Louis, Bykerk, Vivian, Donlin, Laura, Goodman, Susan, DiCarlo, Edward, Smith, Melanie, Lakhanpal, Amit, Sherman, Heather, Singaraju, Anvita, Shakib, Lorien, Ritchlin, Christopher, Boyce, Brendan, Tabechian, Darren, McDavid, Andrew, Rangel-Moreno, Javier, Meednu, Nida, Albrecht, Jen, Wei, Kevin, Helena Jonsson, A, Simmons, Daimon, Keras, Gregory, Keegan, Joshua, Watts, Gerald, Li Zhu, Yuhong, Chicoine, Adam, Jian Li, Zhihan, Gravallese, Ellen M, Howard, Kaitlyn, McGeachy, Mandy, Firestein, Gary S, Boyle, David L, Ceponis, Arnold, Gregersen, Peter K, Horowitz, Diane, Perlman, Harris, Dominguez, Salina, Cuda, Carla M, Mandolin, Arthur M, Thakrar, Anjali, Bathon, Joan M, Hughes, Laura, Michael Holers, V, Seifert, Jennifer, Deane, Kevin, Moreland, Larry W, Filer, Andrew, Raza, Karim, Sahbudin, Ilfita, and Pitzalis, Costantino
- Subjects
Clinical Research ,Kidney Disease ,Lupus ,Autoimmune Disease ,Humans ,Lupus Nephritis ,Prospective Studies ,Incidence ,Proteinuria ,Kidney Function Tests ,Kidney ,systemic lupus erythematosus ,lupus nephritis ,diagnosis ,Accelerating Medicines Partnership (AMP) RA/SLE Network ,Clinical Sciences ,Immunology ,Public Health and Health Services ,Arthritis & Rheumatology - Abstract
ObjectiveDelayed detection of LN associates with worse outcomes. There are conflicting recommendations regarding a threshold level of proteinuria at which biopsy will likely yield actionable management. This study addressed the association of urine protein:creatinine ratios (UPCR) with clinical characteristics and investigated the incidence of proliferative and membranous histology in patients with a UPCR between 0.5 and 1.MethodsA total of 275 SLE patients (113 first biopsy, 162 repeat) were enrolled in the multicentre multi-ethnic/racial Accelerating Medicines Partnership across 15 US sites at the time of a clinically indicated renal biopsy. Patients were followed for 1 year.ResultsAt biopsy, 54 patients had UPCR
- Published
- 2022