Author: "Cucchetti A." - Searchworks@Jio Institute Digital Library Search Results

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2,637 results on '"Cucchetti A."'

1. Recurrence and tumor-related death after resection of hepatocellular carcinoma in patients with metabolic syndrome.

Author: Berardi, Giammauro, Cucchetti, Alessandro, Sposito, Carlo, Ratti, Francesca, Nebbia, Martina, DSouza, Daniel, Pascual, Franco, Dogeas, Epameinondas, Tohme, Samer, Vitale, Alessandro, DAmico, Francesco, Alessandris, Remo, Panetta, Valentina, Simonelli, Ilaria, Colasanti, Marco, Russolillo, Nadia, Moro, Amika, Fiorentini, Guido, Serenari, Matteo, Rotellar, Fernando, Zimitti, Giuseppe, Famularo, Simone, Ivanics, Tommy, Donando, Felipe, Hoffman, Daniel, Onkendi, Edwin, Essaji, Yasmin, Giuliani, Tommaso, Lopez Ben, Santiago, Caula, Celia, Rompianesi, Gianluca, Chopra, Asmita, Abu Hilal, Mohammed, Sapisochin, Gonzalo, Torzilli, Guido, Corvera, Carlos, Alseidi, Adnan, Helton, Scott, Troisi, Roberto, Simo, Kerri, Conrad, Claudius, Cescon, Matteo, Cleary, Sean, Kwon, David, Ferrero, Alessandro, Ettorre, Giuseppe, Cillo, Umberto, Geller, David, Cherqui, Daniel, Serrano, Pablo, Ferrone, Cristina, Aldrighetti, Luca, Kingham, T, and Mazzaferro, Vincenzo
Subjects: Hepatocellular carcinoma, Metabolic syndrome, Metabolic-associated fatty liver disease, Nonalcoholic fatty liver disease, Obesity, Recurrence, Steatosis
Abstract: BACKGROUND & AIMS: Metabolic syndrome (MS) is a growing epidemic and a risk factor for the development of hepatocellular carcinoma (HCC). This study investigated the long-term outcomes of liver resection (LR) for HCC in patients with MS. Rates, timing, patterns, and treatment of recurrences were investigated, and cancer-specific survivals were assessed. METHODS: Between 2001 and 2021, data from 24 clinical centers were collected. Overall survival (OS), recurrence-free survival (RFS), and cancer-specific survival were analyzed as well as recurrence patterns and treatment. The analysis was conducted using a competing-risk framework. The trajectory of the risk of recurrence over time was applied to a competing risk analysis. For post-recurrence survival, death resulting from tumor progression was the primary endpoint, whereas deaths with recurrence relating to other causes were considered as competing events. RESULTS: In total, 813 patients were included in the study. Median OS was 81.4 months (range 28.1-157.0 months), and recurrence occurred in 48.3% of patients, with a median RFS of 39.8 months (range 15.7-174.7 months). Cause-specific hazard of recurrence showed a first peak 6 months (0.027), and a second peak 24 months (0.021) after surgery. The later the recurrence, the higher the chance of receiving curative intent approaches (p = 0.001). Size >5 cm, multiple tumors, microvascular invasion, and cirrhosis were independent predictors of recurrence showing a cause-specific hazard over time. RFS was associated with death for recurrence (hazard ratio: 0.985, 95% CI: 0.977-0.995; p = 0.002). CONCLUSIONS: Patients with MS undergoing LR for HCC have good long-term survival. Recurrence occurs in 48% of patients with a double-peak incidence and time-specific hazards depending on tumor-related factors and underlying disease. The timing of recurrence significantly impacts survival. Surveillance after resection should be adjusted over time depending on risk factors. IMPACT AND IMPLICATIONS: Metabolic syndrome (MS) is a growing epidemic and a significant risk factor for the development of hepatocellular carcinoma (HCC). The present study demonstrated that patients who undergo surgical resection for HCC on MS have a good long-term survival and that recurrence occurs in almost half of the cases with a double peak incidence and time-specific hazards depending on tumor-related factors and underlying liver disease. Also, the timing of recurrence significantly impacts survival. Clinicians should therefore adjust follow-up after surgery accordingly, considering timing of recurrence and specific risk factors. Also, the results of the present study might help design future trials on the use of adjuvant therapy following resection.
Published: 2024

2. Euclid. I. Overview of the Euclid mission

Author: Euclid Collaboration, Mellier, Y., Abdurro'uf, Barroso, J. A. Acevedo, Achúcarro, A., Adamek, J., Adam, R., Addison, G. E., Aghanim, N., Aguena, M., Ajani, V., Akrami, Y., Al-Bahlawan, A., Alavi, A., Albuquerque, I. S., Alestas, G., Alguero, G., Allaoui, A., Allen, S. W., Allevato, V., Alonso-Tetilla, A. V., Altieri, B., Alvarez-Candal, A., Alvi, S., Amara, A., Amendola, L., Amiaux, J., Andika, I. T., Andreon, S., Andrews, A., Angora, G., Angulo, R. E., Annibali, F., Anselmi, A., Anselmi, S., Arcari, S., Archidiacono, M., Aricò, G., Arnaud, M., Arnouts, S., Asgari, M., Asorey, J., Atayde, L., Atek, H., Atrio-Barandela, F., Aubert, M., Aubourg, E., Auphan, T., Auricchio, N., Aussel, B., Aussel, H., Avelino, P. P., Avgoustidis, A., Avila, S., Awan, S., Azzollini, R., Baccigalupi, C., Bachelet, E., Bacon, D., Baes, M., Bagley, M. B., Bahr-Kalus, B., Balaguera-Antolinez, A., Balbinot, E., Balcells, M., Baldi, M., Baldry, I., Balestra, A., Ballardini, M., Ballester, O., Balogh, M., Bañados, E., Barbier, R., Bardelli, S., Baron, M., Barreiro, T., Barrena, R., Barriere, J. -C., Barros, B. J., Barthelemy, A., Bartolo, N., Basset, A., Battaglia, P., Battisti, A. J., Baugh, C. M., Baumont, L., Bazzanini, L., Beaulieu, J. -P., Beckmann, V., Belikov, A. N., Bel, J., Bellagamba, F., Bella, M., Bellini, E., Benabed, K., Bender, R., Benevento, G., Bennett, C. L., Benson, K., Bergamini, P., Bermejo-Climent, J. R., Bernardeau, F., Bertacca, D., Berthe, M., Berthier, J., Bethermin, M., Beutler, F., Bevillon, C., Bhargava, S., Bhatawdekar, R., Bianchi, D., Bisigello, L., Biviano, A., Blake, R. P., Blanchard, A., Blazek, J., Blot, L., Bosco, A., Bodendorf, C., Boenke, T., Böhringer, H., Boldrini, P., Bolzonella, M., Bonchi, A., Bonici, M., Bonino, D., Bonino, L., Bonvin, C., Bon, W., Booth, J. T., Borgani, S., Borlaff, A. S., Borsato, E., Bose, B., Botticella, M. T., Boucaud, A., Bouche, F., Boucher, J. S., Boutigny, D., Bouvard, T., Bouwens, R., Bouy, H., Bowler, R. A. A., Bozza, V., Bozzo, E., Branchini, E., Brando, G., Brau-Nogue, S., Brekke, P., Bremer, M. N., Brescia, M., Breton, M. -A., Brinchmann, J., Brinckmann, T., Brockley-Blatt, C., Brodwin, M., Brouard, L., Brown, M. L., Bruton, S., Bucko, J., Buddelmeijer, H., Buenadicha, G., Buitrago, F., Burger, P., Burigana, C., Busillo, V., Busonero, D., Cabanac, R., Cabayol-Garcia, L., Cagliari, M. S., Caillat, A., Caillat, L., Calabrese, M., Calabro, A., Calderone, G., Calura, F., Quevedo, B. Camacho, Camera, S., Campos, L., Canas-Herrera, G., Candini, G. P., Cantiello, M., Capobianco, V., Cappellaro, E., Cappelluti, N., Cappi, A., Caputi, K. I., Cara, C., Carbone, C., Cardone, V. F., Carella, E., Carlberg, R. G., Carle, M., Carminati, L., Caro, F., Carrasco, J. M., Carretero, J., Carrilho, P., Duque, J. Carron, Carry, B., Carvalho, A., Carvalho, C. S., Casas, R., Casas, S., Casenove, P., Casey, C. M., Cassata, P., Castander, F. J., Castelao, D., Castellano, M., Castiblanco, L., Castignani, G., Castro, T., Cavet, C., Cavuoti, S., Chabaud, P. -Y., Chambers, K. C., Charles, Y., Charlot, S., Chartab, N., Chary, R., Chaumeil, F., Cho, H., Chon, G., Ciancetta, E., Ciliegi, P., Cimatti, A., Cimino, M., Cioni, M. -R. L., Claydon, R., Cleland, C., Clément, B., Clements, D. L., Clerc, N., Clesse, S., Codis, S., Cogato, F., Colbert, J., Cole, R. E., Coles, P., Collett, T. E., Collins, R. S., Colodro-Conde, C., Colombo, C., Combes, F., Conforti, V., Congedo, G., Conseil, S., Conselice, C. J., Contarini, S., Contini, T., Conversi, L., Cooray, A. R., Copin, Y., Corasaniti, P. -S., Corcho-Caballero, P., Corcione, L., Cordes, O., Corpace, O., Correnti, M., Costanzi, M., Costille, A., Courbin, F., Mifsud, L. Courcoult, Courtois, H. M., Cousinou, M. -C., Covone, G., Cowell, T., Cragg, C., Cresci, G., Cristiani, S., Crocce, M., Cropper, M., Crouzet, P. E, Csizi, B., Cuby, J. -G., Cucchetti, E., Cucciati, O., Cuillandre, J. -C., Cunha, P. A. C., Cuozzo, V., Daddi, E., D'Addona, M., Dafonte, C., Dagoneau, N., Dalessandro, E., Dalton, G. B., D'Amico, G., Dannerbauer, H., Danto, P., Das, I., Da Silva, A., da Silva, R., Doumerg, W. d'Assignies, Daste, G., Davies, J. E., Davini, S., Dayal, P., de Boer, T., Decarli, R., De Caro, B., Degaudenzi, H., Degni, G., de Jong, J. T. A., de la Bella, L. F., de la Torre, S., Delhaise, F., Delley, D., Delucchi, G., De Lucia, G., Denniston, J., De Paolis, F., De Petris, M., Derosa, A., Desai, S., Desjacques, V., Despali, G., Desprez, G., De Vicente-Albendea, J., Deville, Y., Dias, J. D. F., Díaz-Sánchez, A., Diaz, J. J., Di Domizio, S., Diego, J. M., Di Ferdinando, D., Di Giorgio, A. M., Dimauro, P., Dinis, J., Dolag, K., Dolding, C., Dole, H., Sánchez, H. Domínguez, Doré, O., Dournac, F., Douspis, M., Dreihahn, H., Droge, B., Dryer, B., Dubath, F., Duc, P. -A., Ducret, F., Duffy, C., Dufresne, F., Duncan, C. A. J., Dupac, X., Duret, V., Durrer, R., Durret, F., Dusini, S., Ealet, A., Eggemeier, A., Eisenhardt, P. R. M., Elbaz, D., Elkhashab, M. Y., Ellien, A., Endicott, J., Enia, A., Erben, T., Vigo, J. A. Escartin, Escoffier, S., Sanz, I. Escudero, Essert, J., Ettori, S., Ezziati, M., Fabbian, G., Fabricius, M., Fang, Y., Farina, A., Farina, M., Farinelli, R., Farrens, S., Faustini, F., Feltre, A., Ferguson, A. M. N., Ferrando, P., Ferrari, A. G., Ferré-Mateu, A., Ferreira, P. G., Ferreras, I., Ferrero, I., Ferriol, S., Ferruit, P., Filleul, D., Finelli, F., Finkelstein, S. L., Finoguenov, A., Fiorini, B., Flentge, F., Focardi, P., Fonseca, J., Fontana, A., Fontanot, F., Fornari, F., Fosalba, P., Fossati, M., Fotopoulou, S., Fouchez, D., Fourmanoit, N., Frailis, M., Fraix-Burnet, D., Franceschi, E., Franco, A., Franzetti, P., Freihoefer, J., Frenk, C. . S., Frittoli, G., Frugier, P. -A., Frusciante, N., Fumagalli, A., Fumagalli, M., Fumana, M., Fu, Y., Gabarra, L., Galeotta, S., Galluccio, L., Ganga, K., Gao, H., García-Bellido, J., Garcia, K., Gardner, J. P., Garilli, B., Gaspar-Venancio, L. -M., Gasparetto, T., Gautard, V., Gavazzi, R., Gaztanaga, E., Genolet, L., Santos, R. Genova, Gentile, F., George, K., Gerbino, M., Ghaffari, Z., Giacomini, F., Gianotti, F., Gibb, G. P. S., Gillard, W., Gillis, B., Ginolfi, M., Giocoli, C., Girardi, M., Giri, S. K., Goh, L. W. K., Gómez-Alvarez, P., Gonzalez-Perez, V., Gonzalez, A. H., Gonzalez, E. J., Gonzalez, J. C., Beauchamps, S. Gouyou, Gozaliasl, G., Gracia-Carpio, J., Grandis, S., Granett, B. R., Granvik, M., Grazian, A., Gregorio, A., Grenet, C., Grillo, C., Grupp, F., Gruppioni, C., Gruppuso, A., Guerbuez, C., Guerrini, S., Guidi, M., Guillard, P., Gutierrez, C. M., Guttridge, P., Guzzo, L., Gwyn, S., Haapala, J., Haase, J., Haddow, C. R., Hailey, M., Hall, A., Hall, D., Hamaus, N., Haridasu, B. S., Harnois-Déraps, J., Harper, C., Hartley, W. G., Hasinger, G., Hassani, F., Hatch, N. A., Haugan, S. V. H., Häußler, B., Heavens, A., Heisenberg, L., Helmi, A., Helou, G., Hemmati, S., Henares, K., Herent, O., Hernández-Monteagudo, C., Heuberger, T., Hewett, P. C., Heydenreich, S., Hildebrandt, H., Hirschmann, M., Hjorth, J., Hoar, J., Hoekstra, H., Holland, A. D., Holliman, M. S., Holmes, W., Hook, I., Horeau, B., Hormuth, F., Hornstrup, A., Hosseini, S., Hu, D., Hudelot, P., Hudson, M. J., Huertas-Company, M., Huff, E. M., Hughes, A. C. N., Humphrey, A., Hunt, L. K., Huynh, D. D., Ibata, R., Ichikawa, K., Iglesias-Groth, S., Ilbert, O., Ilić, S., Ingoglia, L., Iodice, E., Israel, H., Israelsson, U. E., Izzo, L., Jablonka, P., Jackson, N., Jacobson, J., Jafariyazani, M., Jahnke, K., Jain, B., Jansen, H., Jarvis, M. J., Jasche, J., Jauzac, M., Jeffrey, N., Jhabvala, M., Jimenez-Teja, Y., Muñoz, A. Jimenez, Joachimi, B., Johansson, P. H., Joudaki, S., Jullo, E., Kajava, J. J. E., Kang, Y., Kannawadi, A., Kansal, V., Karagiannis, D., Kärcher, M., Kashlinsky, A., Kazandjian, M. V., Keck, F., Keihänen, E., Kerins, E., Kermiche, S., Khalil, A., Kiessling, A., Kiiveri, K., Kilbinger, M., Kim, J., King, R., Kirkpatrick, C. C., Kitching, T., Kluge, M., Knabenhans, M., Knapen, J. H., Knebe, A., Kneib, J. -P., Kohley, R., Koopmans, L. V. E., Koskinen, H., Koulouridis, E., Kou, R., Kovács, A., Kovačić, I., Kowalczyk, A., Koyama, K., Kraljic, K., Krause, O., Kruk, S., Kubik, B., Kuchner, U., Kuijken, K., Kümmel, M., Kunz, M., Kurki-Suonio, H., Lacasa, F., Lacey, C. G., La Franca, F., Lagarde, N., Lahav, O., Laigle, C., La Marca, A., La Marle, O., Lamine, B., Lam, M. C., Lançon, A., Landt, H., Langer, M., Lapi, A., Larcheveque, C., Larsen, S. S., Lattanzi, M., Laudisio, F., Laugier, D., Laureijs, R., Laurent, V., Lavaux, G., Lawrenson, A., Lazanu, A., Lazeyras, T., Boulc'h, Q. Le, Brun, A. M. C. Le, Brun, V. Le, Leclercq, F., Lee, S., Graet, J. Le, Legrand, L., Leirvik, K. N., Jeune, M. Le, Lembo, M., Mignant, D. Le, Lepinzan, M. D., Lepori, F., Reun, A. Le, Leroy, G., Lesci, G. F., Lesgourgues, J., Leuzzi, L., Levi, M. E., Liaudat, T. I., Libet, G., Liebing, P., Ligori, S., Lilje, P. B., Lin, C. -C., Linde, D., Linder, E., Lindholm, V., Linke, L., Li, S. -S., Liu, S. J., Lloro, I., Lobo, F. S. N., Lodieu, N., Lombardi, M., Lombriser, L., Lonare, P., Longo, G., López-Caniego, M., Lopez, X. Lopez, Alvarez, J. Lorenzo, Loureiro, A., Loveday, J., Lusso, E., Macias-Perez, J., Maciaszek, T., Maggio, G., Magliocchetti, M., Magnard, F., Magnier, E. A., Magro, A., Mahler, G., Mainetti, G., Maino, D., Maiorano, E., Malavasi, N., Mamon, G. A., Mancini, C., Mandelbaum, R., Manera, M., Manjón-García, A., Mannucci, F., Mansutti, O., Outeiro, M. Manteiga, Maoli, R., Maraston, C., Marcin, S., Marcos-Arenal, P., Margalef-Bentabol, B., Marggraf, O., Marinucci, D., Marinucci, M., Markovic, K., Marleau, F. R., Marpaud, J., Martignac, J., Martín-Fleitas, J., Martin-Moruno, P., Martin, E. L., Martinelli, M., Martinet, N., Martin, H., Martins, C. J. A. P., Marulli, F., Massari, D., Massey, R., Masters, D. C., Matarrese, S., Matsuoka, Y., Matthew, S., Maughan, B. J., Mauri, N., Maurin, L., Maurogordato, S., McCarthy, K., McConnachie, A. W., McCracken, H. J., McDonald, I., McEwen, J. D., McPartland, C. J. R., Medinaceli, E., Mehta, V., Mei, S., Melchior, M., Melin, J. -B., Ménard, B., Mendes, J., Mendez-Abreu, J., Meneghetti, M., Mercurio, A., Merlin, E., Metcalf, R. B., Meylan, G., Migliaccio, M., Mignoli, M., Miller, L., Miluzio, M., Milvang-Jensen, B., Mimoso, J. P., Miquel, R., Miyatake, H., Mobasher, B., Mohr, J. J., Monaco, P., Monguió, M., Montoro, A., Mora, A., Dizgah, A. Moradinezhad, Moresco, M., Moretti, C., Morgante, G., Morisset, N., Moriya, T. J., Morris, P. W., Mortlock, D. J., Moscardini, L., Mota, D. F., Mottet, S., Moustakas, L. A., Moutard, T., Müller, T., Munari, E., Murphree, G., Murray, C., Murray, N., Musi, P., Nadathur, S., Nagam, B. C., Nagao, T., Naidoo, K., Nakajima, R., Nally, C., Natoli, P., Navarro-Alsina, A., Girones, D. Navarro, Neissner, C., Nersesian, A., Nesseris, S., Nguyen-Kim, H. N., Nicastro, L., Nichol, R. C., Nielbock, M., Niemi, S. -M., Nieto, S., Nilsson, K., Noller, J., Norberg, P., Nouri-Zonoz, A., Ntelis, P., Nucita, A. A., Nugent, P., Nunes, N. J., Nutma, T., Ocampo, I., Odier, J., Oesch, P. A., Oguri, M., Oliveira, D. Magalhaes, Onoue, M., Oosterbroek, T., Oppizzi, F., Ordenovic, C., Osato, K., Pacaud, F., Pace, F., Padilla, C., Paech, K., Pagano, L., Page, M. J., Palazzi, E., Paltani, S., Pamuk, S., Pandolfi, S., Paoletti, D., Paolillo, M., Papaderos, P., Pardede, K., Parimbelli, G., Parmar, A., Partmann, C., Pasian, F., Passalacqua, F., Paterson, K., Patrizii, L., Pattison, C., Paulino-Afonso, A., Paviot, R., Peacock, J. A., Pearce, F. R., Pedersen, K., Peel, A., Peletier, R. F., Ibanez, M. Pellejero, Pello, R., Penny, M. T., Percival, W. J., Perez-Garrido, A., Perotto, L., Pettorino, V., Pezzotta, A., Pezzuto, S., Philippon, A., Pierre, M., Piersanti, O., Pietroni, M., Piga, L., Pilo, L., Pires, S., Pisani, A., Pizzella, A., Pizzuti, L., Plana, C., Polenta, G., Pollack, J. E., Poncet, M., Pöntinen, M., Pool, P., Popa, L. A., Popa, V., Popp, J., Porciani, C., Porth, L., Potter, D., Poulain, M., Pourtsidou, A., Pozzetti, L., Prandoni, I., Pratt, G. W., Prezelus, S., Prieto, E., Pugno, A., Quai, S., Quilley, L., Racca, G. D., Raccanelli, A., Rácz, G., Radinović, S., Radovich, M., Ragagnin, A., Ragnit, U., Raison, F., Ramos-Chernenko, N., Ranc, C., Rasera, Y., Raylet, N., Rebolo, R., Refregier, A., Reimberg, P., Reiprich, T. H., Renk, F., Renzi, A., Retre, J., Revaz, Y., Reylé, C., Reynolds, L., Rhodes, J., Ricci, F., Ricci, M., Riccio, G., Ricken, S. O., Rissanen, S., Risso, I., Rix, H. -W., Robin, A. C., Rocca-Volmerange, B., Rocci, P. -F., Rodenhuis, M., Rodighiero, G., Monroy, M. Rodriguez, Rollins, R. P., Romanello, M., Roman, J., Romelli, E., Romero-Gomez, M., Roncarelli, M., Rosati, P., Rosset, C., Rossetti, E., Roster, W., Rottgering, H. J. A., Rozas-Fernández, A., Ruane, K., Rubino-Martin, J. A., Rudolph, A., Ruppin, F., Rusholme, B., Sacquegna, S., Sáez-Casares, I., Saga, S., Saglia, R., Sahlén, M., Saifollahi, T., Sakr, Z., Salvalaggio, J., Salvaterra, R., Salvati, L., Salvato, M., Salvignol, J. -C., Sánchez, A. G., Sanchez, E., Sanders, D. B., Sapone, D., Saponara, M., Sarpa, E., Sarron, F., Sartori, S., Sartoris, B., Sassolas, B., Sauniere, L., Sauvage, M., Sawicki, M., Scaramella, R., Scarlata, C., Scharré, L., Schaye, J., Schewtschenko, J. A., Schindler, J. -T., Schinnerer, E., Schirmer, M., Schmidt, F., Schmidt, M., Schneider, A., Schneider, M., Schneider, P., Schöneberg, N., Schrabback, T., Schultheis, M., Schulz, S., Schuster, N., Schwartz, J., Sciotti, D., Scodeggio, M., Scognamiglio, D., Scott, D., Scottez, V., Secroun, A., Sefusatti, E., Seidel, G., Seiffert, M., Sellentin, E., Selwood, M., Semboloni, E., Sereno, M., Serjeant, S., Serrano, S., Setnikar, G., Shankar, F., Sharples, R. M., Short, A., Shulevski, A., Shuntov, M., Sias, M., Sikkema, G., Silvestri, A., Simon, P., Sirignano, C., Sirri, G., Skottfelt, J., Slezak, E., Sluse, D., Smith, G. P., Smith, L. C., Smith, R. E., Smit, S. J. A., Soldano, F., Solheim, B. G. B., Sorce, J. G., Sorrenti, F., Soubrie, E., Spinoglio, L., Mancini, A. Spurio, Stadel, J., Stagnaro, L., Stanco, L., Stanford, S. A., Starck, J. -L., Stassi, P., Steinwagner, J., Stern, D., Stone, C., Strada, P., Strafella, F., Stramaccioni, D., Surace, C., Sureau, F., Suyu, S. H., Swindells, I., Szafraniec, M., Szapudi, I., Taamoli, S., Talia, M., Tallada-Crespí, P., Tanidis, K., Tao, C., Tarrío, P., Tavagnacco, D., Taylor, A. N., Taylor, J. E., Taylor, P. L., Teixeira, E. M., Tenti, M., Idiago, P. Teodoro, Teplitz, H. I., Tereno, I., Tessore, N., Testa, V., Testera, G., Tewes, M., Teyssier, R., Theret, N., Thizy, C., Thomas, P. D., Toba, Y., Toft, S., Toledo-Moreo, R., Tolstoy, E., Tommasi, E., Torbaniuk, O., Torradeflot, F., Tortora, C., Tosi, S., Tosti, S., Trifoglio, M., Troja, A., Trombetti, T., Tronconi, A., Tsedrik, M., Tsyganov, A., Tucci, M., Tutusaus, I., Uhlemann, C., Ulivi, L., Urbano, M., Vacher, L., Vaillon, L., Valageas, P., Valdes, I., Valentijn, E. A., Valenziano, L., Valieri, C., Valiviita, J., Broeck, M. Van den, Vassallo, T., Vavrek, R., Vega-Ferrero, J., Venemans, B., Venhola, A., Ventura, S., Kleijn, G. Verdoes, Vergani, D., Verma, A., Vernizzi, F., Veropalumbo, A., Verza, G., Vescovi, C., Vibert, D., Viel, M., Vielzeuf, P., Viglione, C., Viitanen, A., Villaescusa-Navarro, F., Vinciguerra, S., Visticot, F., Voggel, K., von Wietersheim-Kramsta, M., Vriend, W. J., Wachter, S., Walmsley, M., Walth, G., Walton, D. M., Walton, N. A., Wander, M., Wang, L., Wang, Y., Weaver, J. R., Weller, J., Wetzstein, M., Whalen, D. J., Whittam, I. H., Widmer, A., Wiesmann, M., Wilde, J., Williams, O. R., Winther, H. -A., Wittje, A., Wong, J. H. W., Wright, A. H., Yankelevich, V., Yeung, H. W., Yoon, M., Youles, S., Yung, L. Y. A., Zacchei, A., Zalesky, L., Zamorani, G., Vitorelli, A. Zamorano, Marc, M. Zanoni, Zennaro, M., Zerbi, F. M., Zinchenko, I. A., Zoubian, J., Zucca, E., and Zumalacarregui, M.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The current standard model of cosmology successfully describes a variety of measurements, but the nature of its main ingredients, dark matter and dark energy, remains unknown. Euclid is a medium-class mission in the Cosmic Vision 2015-2025 programme of the European Space Agency (ESA) that will provide high-resolution optical imaging, as well as near-infrared imaging and spectroscopy, over about 14,000 deg^2 of extragalactic sky. In addition to accurate weak lensing and clustering measurements that probe structure formation over half of the age of the Universe, its primary probes for cosmology, these exquisite data will enable a wide range of science. This paper provides a high-level overview of the mission, summarising the survey characteristics, the various data-processing steps, and data products. We also highlight the main science objectives and expected performance., Comment: Accepted for publication in the A&A special issue`Euclid on Sky'
Published: 2024

3. Toward mapping turbulence in the intracluster medium III. Constraints on the turbulent power spectrum with Athena/X-IFU

Author: Beaumont, Sophie, Molin, Alexeï, Clerc, Nicolas, Pointecouteau, Étienne, Vanel, Mélina, Cucchetti, Edoardo, Peille, Philippe, and Pajot, François
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Context. Future X-ray observatories with high spectral resolution and imaging capabilities will enable measurements and mappings of emission line shifts in the intracluster medium (ICM). Such direct measurements can serve as unique probes of turbulent motions in the ICM. Determining the level and scales of turbulence will improve our understanding of the galaxy cluster dynamical evolution and assembly, together with a more precise evaluation of the non thermal support pressure budget. This will allow for more accurate constraints to be placed on the masses of galaxy clusters, among other potential benfits. Aims. In this view, we implemented the methods presented in the previous instalments of our work to characterize the turbulence in the ICM in a feasibility study with the X-IFU on board the future European X-ray observatory, Athena. Methods. From idealized mock observations of a toy model cluster, we reconstructed the second-order structure function built with the observed velocity field to constrain the turbulence. We carefully accounted for the various sources of errors to derive the most realistic and comprehensive error budget within the limits of our approach. With prior assumptions on the dissipation scale and power spectrum slope, we constrained the parameters of the turbulent power spectrum model through the use of MCMC sampling. Results. With favourable assumptions, we were able to retrieve the injection scale, velocity dispersion, and power spectrum slope, with 1sigma uncertainties better than ~15% of the input values. We demonstrated the efficiency of our carefully set framework to constrain the turbulence in the ICM from high-resolution X-ray spectroscopic observations, paving the way for more in-depth investigation of the optimal required observing strategy within a more restrictive observational setup with the future X-IFU instrument., Comment: Accepted for publication in Astronomy and Astrophysics
Published: 2024
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4. Italian survey about intraperitoneal drain use in distal pancreatectomy

Author: Pecorelli, Nicolò, Ricci, Claudio, Esposito, Alessandro, Capretti, Giovanni, Partelli, Stefano, Butturini, Giovanni, Boggi, Ugo, Cucchetti, Alessandro, Zerbi, Alessandro, Salvia, Roberto, and Falconi, Massimo
Published: 2024
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5. Survival After Transarterial Radioembolization in Patients with Unresectable Intrahepatic Cholangiocarcinoma: An Updated Meta-analysis and Meta-regression

Author: Cocozza, Maria Adriana, Dajti, Elton, Braccischi, Lorenzo, Modestino, Francesco, Reimer, Peter, Cucchetti, Alessandro, Barbara, Giovanni, and Mosconi, Cristina
Published: 2024
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6. Radiomics of Intrahepatic Cholangiocarcinoma and Peritumoral Tissue Predicts Postoperative Survival: Development of a CT-Based Clinical-Radiomic Model

Author: Fiz, Francesco, Rossi, Noemi, Langella, Serena, Conci, Simone, Serenari, Matteo, Ardito, Francesco, Cucchetti, Alessandro, Gallo, Teresa, Zamboni, Giulia A., Mosconi, Cristina, Boldrini, Luca, Mirarchi, Mariateresa, Cirillo, Stefano, Ruzzenente, Andrea, Pecorella, Ilaria, Russolillo, Nadia, Borzi, Martina, Vara, Giulio, Mele, Caterina, Ercolani, Giorgio, Giuliante, Felice, Cescon, Matteo, Guglielmi, Alfredo, Ferrero, Alessandro, Sollini, Martina, Chiti, Arturo, Torzilli, Guido, Ieva, Francesca, and Viganò, Luca
Published: 2024
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7. A snapshot on current approaches to lymphadenectomy in liver resection for intrahepatic cholangiocarcinoma: results from an international survey

Author: Sposito, Carlo, Maspero, Marianna, Cucchetti, Alessandro, and Mazzaferro, Vincenzo
Published: 2024
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8. REDISCOVER guidelines for borderline-resectable and locally advanced pancreatic cancer: management algorithm, unanswered questions, and future perspectives

Author: Boggi, Ugo, Kauffmann, Emanuele F., Napoli, Niccolò, Barreto, S. George, Besselink, Marc G., Fusai, Giuseppe K., Hackert, Thilo, Hilal, Mohammad Abu, Marchegiani, Giovanni, Salvia, Roberto, Shrikhande, Shailesh V., Truty, Mark, Werner, Jens, Wolfgang, Christopher, Bannone, Elisa, Capretti, Giovanni, Cattelani, Alice, Coppola, Alessandro, Cucchetti, Alessandro, De Sio, Davide, Di Dato, Armando, Di Meo, Giovanna, Fiorillo, Claudio, Gianfaldoni, Cesare, Ginesini, Michael, Hidalgo Salinas, Camila, Lai, Quirino, Miccoli, Mario, Montorsi, Roberto, Pagnanelli, Michele, Poli, Andrea, Ricci, Claudio, Sucameli, Francesco, Tamburrino, Domenico, Viti, Virginia, Cameron, John, Clavien, Pierre-Alain, and Asbun, Horacio J.
Published: 2024
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9. Advanced Energy Scale Correction Techniques for the X-ray Transition Edge Sensors of the Athena mission

Author: Cucchetti, E., Smith, S. J., Witthoeft, M. C., Eckart, M., Pajot, F., Peille, P., and Porter, F. S.
Published: 2024
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10. Intraperitoneal prophylactic drain after pancreaticoduodenectomy: an Italian survey

Author: Ricci, Claudio, Pecorelli, Nicolò, Esposito, Alessandro, Capretti, Giovanni, Partelli, Stefano, Butturini, Giovanni, Boggi, Ugo, Cucchetti, Alessandro, Zerbi, Alessandro, Salvia, Roberto, and Falconi, Massimo
Published: 2024
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11. ASO Visual Abstract: Radiomics of Intrahepatic Cholangiocarcinoma and Peritumoral Tissue Predicts Postoperative Survival: Development of a CT-Based Clinical-Radiomic Model

Author: Fiz, Francesco, Rossi, Noemi, Langella, Serena, Conci, Simone, Serenari, Matteo, Ardito, Francesco, Cucchetti, Alessandro, Gallo, Teresa, Zamboni, Giulia A., Mosconi, Cristina, Boldrini, Luca, Mirarchi, Mariateresa, Cirillo, Stefano, Ruzzenente, Andrea, Pecorella, Ilaria, Russolillo, Nadia, Borzi, Martina, Vara, Giulio, Mele, Caterina, Ercolani, Giorgio, Giuliante, Felice, Cescon, Matteo, Guglielmi, Alfredo, Ferrero, Alessandro, Sollini, Martina, Chiti, Arturo, Torzilli, Guido, Ieva, Francesca, and Viganò, Luca
Published: 2024
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12. Risk factors and scores for prediction of coronary artery aneurysms in Kawasaki disease: a European monocentric study

Author: La Vecchia, Adriano, Stracquadaino, Rita, Mauri, Lucia, Baselli, Lucia Augusta, Abdallah, Rozan, Cucchetti, Martina, Colli, Anna Maria, Agostoni, Carlo, and Dellepiane, Rosa Maria
Published: 2024
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13. The Cryo-Harness Technology for the Athena X-IFU Detection Chain

Author: Geoffray, H., Adams, J., Fossecave, H., Cucchetti, E., Bellouard, E., Peille, P., Daniel, C., Maisonnave, O., Guilhem, E., Jolly, A., Maussang, I., Jackon, B., Bandler, S., Doriese, B., Durkin, M., van der Kuur, J., van Leeuwen, B. J., Kiviranta, M., Prêle, D., Ravera, L., and Parot, Y.
Published: 2024
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14. Impedance Matching Between SQUID and Warm Amplifier for TES Readout in TDM for the ATHENA X-IFU Instrument

Author: Gonzalez, Manuel, Parot, Yann, Prele, Damien, Kirsch, Christian, Cucchetti, Edoardo, Peille, Philippe, Murat, David, Ravera, Laurent, and Van der Kuur, Jan
Published: 2024
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15. Enhanced Image Processing for the CASPEX Cameras Onboard the Rashid-1 Rover

Author: Théret, Nicolas, Cucchetti, Edoardo, Robert, Emilie, Virmontois, Cédric, Millancourt, Charles, Douaglin, Quentin, Amsili, Alice, Belloir, Jean-Marc, Amilineni, Santosh, Khoory, Mohammed, Ioannou, Zacharias, Lalucaa, Valerian, Lucas, Sylvain, and Yana, Charles
Published: 2024
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16. Correction: Intraperitoneal prophylactic drain after pancreaticoduodenectomy: an Italian survey

Author: Ricci, Claudio, Pecorelli, Nicolò, Esposito, Alessandro, Capretti, Giovanni, Partelli, Stefano, Butturini, Giovanni, Boggi, Ugo, Cucchetti, Alessandro, Zerbi, Alessandro, Salvia, Roberto, and Falconi, Massimo
Published: 2024
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17. Anicet Le Pors (1931-) comunismo francés, tecnocracia y disidencia. Los sentidos de la contradicción en una trayectoria comunista

Author: Cucchetti, Humberto
Published: 2024

18. The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase

Author: Barret, Didier, Albouys, Vincent, Herder, Jan-Willem den, Piro, Luigi, Cappi, Massimo, Huovelin, Juhani, Kelley, Richard, Mas-Hesse, J. Miguel, Paltani, Stéphane, Rauw, Gregor, Rozanska, Agata, Svoboda, Jiri, Wilms, Joern, Yamasaki, Noriko, Audard, Marc, Bandler, Simon, Barbera, Marco, Barcons, Xavier, Bozzo, Enrico, Ceballos, Maria Teresa, Charles, Ivan, Costantini, Elisa, Dauser, Thomas, Decourchelle, Anne, Duband, Lionel, Duval, Jean-Marc, Fiore, Fabrizio, Gatti, Flavio, Goldwurm, Andrea, Hartog, Roland den, Jackson, Brian, Jonker, Peter, Kilbourne, Caroline, Korpela, Seppo, Macculi, Claudio, Mendez, Mariano, Mitsuda, Kazuhisa, Molendi, Silvano, Pajot, François, Pointecouteau, Etienne, Porter, Frederick, Pratt, Gabriel W., Prêle, Damien, Ravera, Laurent, Sato, Kosuke, Schaye, Joop, Shinozaki, Keisuke, Skup, Konrad, Soucek, Jan, Thibert, Tanguy, Vink, Jacco, Webb, Natalie, Chaoul, Laurence, Raulin, Desi, Simionescu, Aurora, Torrejon, Jose Miguel, Acero, Fabio, Branduardi-Raymont, Graziella, Ettori, Stefano, Finoguenov, Alexis, Grosso, Nicolas, Kaastra, Jelle, Mazzotta, Pasquale, Miller, Jon, Miniutti, Giovanni, Nicastro, Fabrizio, Sciortino, Salvatore, Yamaguchi, Hiroya, Beaumont, Sophie, Cucchetti, Edoardo, D'Andrea, Matteo, Eckart, Megan, Ferrando, Philippe, Kammoun, Elias, Lotti, Simone, Mesnager, Jean-Michel, Natalucci, Lorenzo, Peille, Philippe, de Plaa, Jelle, Ardellier, Florence, Argan, Andrea, Bellouard, Elise, Carron, Jérôme, Cavazzuti, Elisabetta, Fiorini, Mauro, Khosropanah, Pourya, Martin, Sylvain, Perry, James, Pinsard, Frederic, Pradines, Alice, Rigano, Manuela, Roelfsema, Peter, Schwander, Denis, Torrioli, Guido, Ullom, Joel, Vera, Isabel, Villegas, Eduardo Medinaceli, Zuchniak, Monika, Brachet, Frank, Cicero, Ugo Lo, Doriese, William, Durkin, Malcom, Fioretti, Valentina, Geoffray, Hervé, Jacques, Lionel, Kirsch, Christian, Smith, Stephen, Adams, Joseph, Gloaguen, Emilie, Hoogeveen, Ruud, van der Hulst, Paul, Kiviranta, Mikko, van der Kuur, Jan, Ledot, Aurélien, van Leeuwen, Bert-Joost, van Loon, Dennis, Lyautey, Bertrand, Parot, Yann, Sakai, Kazuhiro, van Weers, Henk, Abdoelkariem, Shariefa, Adam, Thomas, Adami, Christophe, Aicardi, Corinne, Akamatsu, Hiroki, Alonso, Pablo Eleazar Merino, Amato, Roberta, André, Jérôme, Angelinelli, Matteo, Anon-Cancela, Manuel, Anvar, Shebli, Atienza, Ricardo, Attard, Anthony, Auricchio, Natalia, Balado, Ana, Bancel, Florian, Barusso, Lorenzo Ferrari, Bernard, Vivian, Berrocal, Alicia, Blin, Sylvie, Bonino, Donata, Bonnet, François, Bonny, Patrick, Boorman, Peter, Boreux, Charles, Bounab, Ayoub, Boutelier, Martin, Boyce, Kevin, Brienza, Daniele, Bruijn, Marcel, Bulgarelli, Andrea, Calarco, Simona, Callanan, Paul, Camus, Thierry, Canourgues, Florent, Capobianco, Vito, Cardiel, Nicolas, Castellani, Florent, Cheatom, Oscar, Chervenak, James, Chiarello, Fabio, Clerc, Nicolas, Clerc, Laurent, Cobo, Beatriz, Coeur-Joly, Odile, Coleiro, Alexis, Colonges, Stéphane, Corcione, Leonardo, Coriat, Mickael, Coynel, Alexandre, Cuttaia, Francesco, D'Ai, Antonino, D'anca, Fabio, Dadina, Mauro, Daniel, Christophe, DeNigris, Natalie, Dercksen, Johannes, DiPirro, Michael, Doumayrou, Eric, Dubbeldam, Luc, Dupieux, Michel, Dupourqué, Simon, Durand, Jean Louis, Eckert, Dominique, Eiriz, Valvanera, Ercolani, Eric, Etcheverry, Christophe, Finkbeiner, Fred, Fiocchi, Mariateresa, Fossecave, Hervé, Franssen, Philippe, Frericks, Martin, Gabici, Stefano, Gant, Florent, Gao, Jian-Rong, Gastaldello, Fabio, Genolet, Ludovic, Ghizzardi, Simona, Gil, M Angeles Alcacera, Giovannini, Elisa, Godet, Olivier, Gomez-Elvira, Javier, Gonzalez, Manuel, Gonzalez, Raoul, Gottardi, Luciano, Granat, Dolorès, Gros, Michel, Guignard, Nicolas, Hieltjes, Paul, Hurtado, Adolfo Jesus, Irwin, Kent, Jacquey, Christian, Janiuk, Agnieszka, Jaubert, Jean, Jiménez, Maria, Jolly, Antoine, Jourdan, Thierry, Julien, Sabine, Kedziora, Bartosz, Korb, Andrew, Kreykenbohm, Ingo, König, Ole, Langer, Mathieu, Laudet, Philippe, Laurent, Philippe, Laurenza, Monica, Lesrel, Jean, Ligori, Sebastiano, Lorenz, Maximilian, Luminari, Alfredo, Maffei, Bruno, Maisonnave, Océane, Marelli, Lorenzo, Massonet, Didier, Maussang, Irwin, Melchor, Alejandro Gonzalo, Mer, Isabelle Le, Michalski, Lea, Millerioux, Jean-Pierre, Mineo, Teresa, Minervini, Gabriele, Molin, Alexeï, Monestes, David, Montinaro, Nicola, Mot, Baptiste, Murat, David, Nagayoshi, Kenichiro, Nazé, Yaël, Noguès, Loïc, Pailot, Damien, Panessa, Francesca, Parodi, Luigi, Petit, Pascal, Piconcelli, Enrico, Pinto, Ciro, Plaza, Jose Miguel Encinas, Poyatos, David, Prouvé, Thomas, Ptak, Andy, Puccetti, Simonetta, Puccio, Elena, Ramon, Pascale, Reina, Manuel, Rioland, Guillaume, Rodriguez, Louis, Roig, Anton, Rollet, Bertrand, Roncarelli, Mauro, Roudil, Gilles, Rudnicki, Tomasz, Sanisidro, Julien, Sciortino, Luisa, Silva, Vitor, Sordet, Michael, Soto-Aguilar, Javier, Spizzi, Pierre, Surace, Christian, Sánchez, Miguel Fernández, Taralli, Emanuele, Terrasa, Guilhem, Terrier, Régis, Todaro, Michela, Ubertini, Pietro, Uslenghi, Michela, de Vaate, Jan Geralt Bij, Vaccaro, Davide, Varisco, Salvatore, Varnière, Peggy, Vibert, Laurent, Vidriales, María, Villa, Fabrizio, Vodopivec, Boris Martin, Volpe, Angela, de Vries, Cor, Wakeham, Nicholas, Walmsley, Gavin, Wise, Michael, de Wit, Martin, and Woźniak, Grzegorz
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract: The Athena X-ray Integral Unit (X-IFU) is the high resolution X-ray spectrometer, studied since 2015 for flying in the mid-30s on the Athena space X-ray Observatory, a versatile observatory designed to address the Hot and Energetic Universe science theme, selected in November 2013 by the Survey Science Committee. Based on a large format array of Transition Edge Sensors (TES), it aims to provide spatially resolved X-ray spectroscopy, with a spectral resolution of 2.5 eV (up to 7 keV) over an hexagonal field of view of 5 arc minutes (equivalent diameter). The X-IFU entered its System Requirement Review (SRR) in June 2022, at about the same time when ESA called for an overall X-IFU redesign (including the X-IFU cryostat and the cooling chain), due to an unanticipated cost overrun of Athena. In this paper, after illustrating the breakthrough capabilities of the X-IFU, we describe the instrument as presented at its SRR, browsing through all the subsystems and associated requirements. We then show the instrument budgets, with a particular emphasis on the anticipated budgets of some of its key performance parameters. Finally we briefly discuss on the ongoing key technology demonstration activities, the calibration and the activities foreseen in the X-IFU Instrument Science Center, and touch on communication and outreach activities, the consortium organisation, and finally on the life cycle assessment of X-IFU aiming at minimising the environmental footprint, associated with the development of the instrument. Thanks to the studies conducted so far on X-IFU, it is expected that along the design-to-cost exercise requested by ESA, the X-IFU will maintain flagship capabilities in spatially resolved high resolution X-ray spectroscopy, enabling most of the original X-IFU related scientific objectives of the Athena mission to be retained. (abridged)., Comment: 48 pages, 29 figures, Accepted for publication in Experimental Astronomy with minor editing
Published: 2022
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19. Recurrence and tumor-related death after resection of hepatocellular carcinoma in patients with metabolic syndrome

Author: Giammauro Berardi, Alessandro Cucchetti, Carlo Sposito, Francesca Ratti, Martina Nebbia, Daniel M. D’Souza, Franco Pascual, Epameinondas Dogeas, Samer Tohme, Alessandro Vitale, Francesco Enrico D’Amico, Remo Alessandris, Valentina Panetta, Ilaria Simonelli, Marco Colasanti, Nadia Russolillo, Amika Moro, Guido Fiorentini, Matteo Serenari, Fernando Rotellar, Giuseppe Zimitti, Simone Famularo, Tommy Ivanics, Felipe Gaviria Donando, Daniel Hoffman, Edwin Onkendi, Yasmin Essaji, Tommaso Giuliani, Santiago Lopez Ben, Celia Caula, Gianluca Rompianesi, Asmita Chopra, Mohammed Abu Hilal, Gonzalo Sapisochin, Guido Torzilli, Carlos Corvera, Adnan Alseidi, Scott Helton, Roberto I. Troisi, Kerri Simo, Claudius Conrad, Matteo Cescon, Sean Cleary, David Choon Hyuck Kwon, Alessandro Ferrero, Giuseppe Maria Ettorre, Umberto Cillo, David Geller, Daniel Cherqui, Pablo E. Serrano, Cristina Ferrone, Luca Aldrighetti, T. Peter Kingham, and Vincenzo Mazzaferro
Subjects: Hepatocellular carcinoma, Metabolic syndrome, Nonalcoholic fatty liver disease, Metabolic-associated fatty liver disease, Recurrence, Steatosis, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Background & Aims: Metabolic syndrome (MS) is a growing epidemic and a risk factor for the development of hepatocellular carcinoma (HCC). This study investigated the long-term outcomes of liver resection (LR) for HCC in patients with MS. Rates, timing, patterns, and treatment of recurrences were investigated, and cancer-specific survivals were assessed. Methods: Between 2001 and 2021, data from 24 clinical centers were collected. Overall survival (OS), recurrence-free survival (RFS), and cancer-specific survival were analyzed as well as recurrence patterns and treatment. The analysis was conducted using a competing-risk framework. The trajectory of the risk of recurrence over time was applied to a competing risk analysis. For post-recurrence survival, death resulting from tumor progression was the primary endpoint, whereas deaths with recurrence relating to other causes were considered as competing events. Results: In total, 813 patients were included in the study. Median OS was 81.4 months (range 28.1–157.0 months), and recurrence occurred in 48.3% of patients, with a median RFS of 39.8 months (range 15.7–174.7 months). Cause-specific hazard of recurrence showed a first peak 6 months (0.027), and a second peak 24 months (0.021) after surgery. The later the recurrence, the higher the chance of receiving curative intent approaches (p = 0.001). Size >5 cm, multiple tumors, microvascular invasion, and cirrhosis were independent predictors of recurrence showing a cause-specific hazard over time. RFS was associated with death for recurrence (hazard ratio: 0.985, 95% CI: 0.977–0.995; p = 0.002). Conclusions: Patients with MS undergoing LR for HCC have good long-term survival. Recurrence occurs in 48% of patients with a double-peak incidence and time-specific hazards depending on tumor-related factors and underlying disease. The timing of recurrence significantly impacts survival. Surveillance after resection should be adjusted over time depending on risk factors. Impact and implications: Metabolic syndrome (MS) is a growing epidemic and a significant risk factor for the development of hepatocellular carcinoma (HCC). The present study demonstrated that patients who undergo surgical resection for HCC on MS have a good long-term survival and that recurrence occurs in almost half of the cases with a double peak incidence and time-specific hazards depending on tumor-related factors and underlying liver disease. Also, the timing of recurrence significantly impacts survival. Clinicians should therefore adjust follow-up after surgery accordingly, considering timing of recurrence and specific risk factors. Also, the results of the present study might help design future trials on the use of adjuvant therapy following resection.
Published: 2024
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20. Cure Probabilities After Resection of Pancreatic Ductal Adenocarcinoma: A Multi-Institutional Analysis of 2554 Patients

Author: Crippa, Stefano, Malleo, Giuseppe, Langella, Serena, Ricci, Claudio, Casciani, Fabio, Belfiori, Giulio, Galati, Sara, Ingaldi, Carlo, Lionetto, Gabriella, Ferrero, Alessandro, Casadei, Riccardo, Ercolani, Giorgio, Salvia, Roberto, Falconi, Massimo, and Cucchetti, Alessandro
Published: 2024
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21. Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines.

Author: Coccolini, Federico, Corradi, Francesco, Sartelli, Massimo, Coimbra, Raul, Kryvoruchko, Igor, Leppaniemi, Ari, Doklestic, Krstina, Bignami, Elena, Biancofiore, Giandomenico, Bala, Miklosh, Marco, Ceresoli, Damaskos, Dimitris, Biffl, Walt, Fugazzola, Paola, Santonastaso, Domenico, Agnoletti, Vanni, Sbarbaro, Catia, Nacoti, Mirco, Hardcastle, Timothy, Mariani, Diego, De Simone, Belinda, Tolonen, Matti, Ball, Chad, Podda, Mauro, Di Carlo, Isidoro, Di Saverio, Salomone, Navsaria, Pradeep, Bonavina, Luigi, Abu-Zidan, Fikri, Soreide, Kjetil, Fraga, Gustavo, Carvalho, Vanessa, Batista, Sergio, Hecker, Andreas, Cucchetti, Alessandro, Ercolani, Giorgio, Tartaglia, Dario, Wani, Imtiaz, Kurihara, Hayato, Tan, Edward, Litvin, Andrey, Melotti, Rita, Sganga, Gabriele, Zoro, Tamara, Isirdi, Alessandro, DeAngelis, Nicola, Weber, Dieter, Hodonou, Adrien, tenBroek, Richard, Parini, Dario, Khan, Jim, Sbrana, Giovanni, Coniglio, Carlo, Giarratano, Antonino, Gratarola, Angelo, Zaghi, Claudia, Romeo, Oreste, Kelly, Michael, Forfori, Francesco, Chiarugi, Massimo, Moore, Ernest, Catena, Fausto, Malbrain, Manu, and Galante, Joseph
Subjects: Acute, Emergency, Morbidity, Pain, Surgery, Treatment, Abdomen, Analgesics, Anesthesia, Humans, Pain, Postoperative, Perioperative Care, United States
Abstract: BACKGROUND: Non-traumatic emergency general surgery involves a heterogeneous population that may present with several underlying diseases. Timeous emergency surgical treatment should be supplemented with high-quality perioperative care, ideally performed by multidisciplinary teams trained to identify and handle complex postoperative courses. Uncontrolled or poorly controlled acute postoperative pain may result in significant complications. While pain management after elective surgery has been standardized in perioperative pathways, the traditional perioperative treatment of patients undergoing emergency surgery is often a haphazard practice. The present recommended pain management guidelines are for pain management after non-traumatic emergency surgical intervention. It is meant to provide clinicians a list of indications to prescribe the optimal analgesics even in the absence of a multidisciplinary pain team. MATERIAL AND METHODS: An international expert panel discussed the different issues in subsequent rounds. Four international recognized scientific societies: World Society of Emergency Surgery (WSES), Global Alliance for Infection in Surgery (GAIS), Italian Society of Anesthesia, Analgesia Intensive Care (SIAARTI), and American Association for the Surgery of Trauma (AAST), endorsed the project and approved the final manuscript. CONCLUSION: Dealing with acute postoperative pain in the emergency abdominal surgery setting is complex, requires special attention, and should be multidisciplinary. Several tools are available, and their combination is mandatory whenever is possible. Analgesic approach to the various situations and conditions should be patient based and tailored according to procedure, pathology, age, response, and available expertise. A better understanding of the patho-mechanisms of postoperative pain for short- and long-term outcomes is necessary to improve prophylactic and treatment strategies.
Published: 2022

22. The 1st i-EUS consensus on the management of pancreatic fluid collections – Part 2

Author: Aragona, Giovanni, Arcidiacono, Paolo Giorgio, Arvanitaki, Marianna, Badas, Roberta, Barresi, Luca, Berretti, Debora, Bocus, Paolo, Camellini, Lorenzo, Cintorino, Davide, Cugia, Luigi, Dabizzi, Emanuele, De Angelis, Claudio Giovanni, Blanco, Giovanna Del Vecchio, Matteo, Francesco Maria Di, Mitri, Roberto Di, Ercolani, Giorgio, Falconi, Massimo, Fantin, Alberto, Ligresti, Dario, Macchiarelli, Raffaele, Mangiafico, Santi, Mangiavillano, Benedetto, Manno, Mauro, Maruzzelli, Luigi, Marzioni, Marco, Pedicini, Vittorio, Piras, Enrico, Pollino, Valeria, Sethi, Amrita, Siddiqui, Uzma, Togliani, Thomas, Traina, Mario, Tringali, Alberto, Venezia, Giovanna, Zerbi, Alessandro, Capurso, Gabriele, Coluccio, Chiara, Rizzo, Giacomo Emanuele Maria, Crinò, Stefano Francesco, Cucchetti, Alessandro, Facciorusso, Antonio, Hassan, Cesare, Amato, Arnaldo, Auriemma, Francesco, Bertani, Helga, Binda, Cecilia, Cipolletta, Fabio, Forti, Edoardo, Fugazza, Alessandro, Lisotti, Andrea, Maida, Marcello, Sinagra, Emanuele, Sbrancia, Monica, Spadaccini, Marco, Tacelli, Matteo, Vanella, Giuseppe, Anderloni, Andrea, Fabbri, Carlo, and Tarantino, Ilaria
Published: 2024
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23. Risk factors and scores for prediction of coronary artery aneurysms in Kawasaki disease: a European monocentric study

Author: Adriano La Vecchia, Rita Stracquadaino, Lucia Mauri, Lucia Augusta Baselli, Rozan Abdallah, Martina Cucchetti, Anna Maria Colli, Carlo Agostoni, and Rosa Maria Dellepiane
Subjects: Kawasaki disease, Aneurysm, Risk scores, Risk factors, Outcome, Cardiology, Pediatrics, RJ1-570
Abstract: Abstract Background Japanese Kawasaki disease (KD) risk scores cannot be adopted in non-Japanese patients. In North American populations a baseline coronary artery Z-score > 2 and the Son score are associated with coronary artery aneurysms (CAAs) at 4 and 8 weeks from disease onset. In European populations, the Kawanet and Kawanet-echo scores are associated with intravenous immunoglobulin resistance. This study aims to evaluate the association between KD risk scores and baseline coronary artery Z-scores with CAAs at one, two, and six months in a European population. Methods Historical cohort study of all the children diagnosed with KD in a tertiary care hospital in Milan, Italy, between 1st January 2015 and 31st May 2021. Univariate and multivariate (adjusting for age and corticosteroid therapy) logistic regression analyses were used to study the association between the risk scores, a baseline Z-score ≥ 2 and ≥ 2.5 with CAAs. Results Eighty-nine patients were diagnosed with KD at our Centre, and 12 were excluded based on the exclusion criteria. We included 77 patients, 51 (66%) males, and 26 (34%) females, with a median age at presentation of 27 months (IQR 13–46). A baseline Z-score ≥ 2 was correlated with CAAs at one and two-month follow-ups (odds ratio (OR) 10, 95% confidence interval (CI) 2–72, and OR 18, CI 3-357) but not at six-month follow-up. The Son score showed an association with one and two-month follow-up CAAs (OR 3, CI 1.3-7, and OR 3, CI 1.3-8) but not with a six-month follow-up. Conclusions Patients with a baseline Z-score ≥ 2 are at higher risk for CAAs in the long term. The Son score should be tested in larger European samples. Further studies should keep the observational periods longer than 8 weeks from KD onset.
Published: 2024
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24. REDISCOVER International Guidelines on the Perioperative Care of Surgical Patients With Borderline-resectable and Locally Advanced Pancreatic Cancer

Author: Boggi, Ugo, Kauffmann, Emanuele, Napoli, Niccolò, Barreto, S. George, Besselink, Marc G., Fusai, Giuseppe K., Hackert, Thilo, Abu Hilal, Mohammad, Marchegiani, Giovanni, Salvia, Roberto, Shrikhande, Shailesh V., Truty, Mark, Werner, Jens, Wolfgang, Christopher L., Bannone, Elisa, Capretti, Giovanni, Cattelani, Alice, Coppola, Alessandro, Cucchetti, Alessandro, De Sio, Davide, Di Dato, Armando, Di Meo, Giovanna, Fiorillo, Claudio, Gianfaldoni, Cesare, Ginesini, Michael, Hidalgo Salinas, Camila, Lai, Quirino, Miccoli, Mario, Montorsi, Roberto, Pagnanelli, Michele, Poli, Andrea, Ricci, Claudio, Sucameli, Francesco, Tamburrino, Domenico, Viti, Virginia, Addeo, Pietro F., Alfieri, Sergio, Bachellier, Philippe, Baiocchi, Gian Luca, Balzano, Gianpaolo, Barbarello, Linda, Brolese, Alberto, Busquets, Juli, Butturini, Giovanni, Caniglia, Fabio, Caputo, Damiano, Casadei, Riccardo, Chunhua, Xi, Colangelo, Ettore, Coratti, Andrea, Costa, Francesca, Crafa, Francesco, Dalla Valle, Raffaele, De Carlis, Luciano, de Wilde, Roeland F., Del Chiaro, Marco, Di Benedetto, Fabrizio, Di Sebastiano, Pierluigi, Dokmak, Safi, Hogg, Melissa, Egorov, Vyacheslav I., Ercolani, Giorgio, Ettorre, Giuseppe Maria, Falconi, Massimo, Ferrari, Giovanni, Ferrero, Alessandro, Filauro, Marco, Giardino, Alessandro, Grazi, Gian Luca, Gruttadauria, Salvatore, Izbicki, Jakob R, Jovine, Elio, Katz, Matthew, Keck, Tobias, Khatkov, Igor, Kiguchi, Gozo, Kooby, David, Lang, Hauke, Lombardo, Carlo, Malleo, Giuseppe, Massani, Marco, Mazzaferro, Vincenzo, Memeo, Riccardo, Miao, Yi, Mishima, Kohei, Molino, Carlo, Nagakawa, Yuichi, Nakamura, Masafumi, Nardo, Bruno, Panaro, Fabrizio, Pasquali, Claudio, Perrone, Vittorio, Rangelova, Elena, Liu, Rong, Romagnoli, Renato, Romito, Raffaele, Rosso, Edoardo, Schulick, Richard, Siriwardena, Ajith, Spampinato, Marcello Giuseppe, Strobel, Oliver, Testini, Mario, Troisi, Roberto Ivan, Uzunoglo, Faik G., Valente, Roberto, Veneroni, Luigi, Zerbi, Alessandro, Vicente, Emilio, Vistoli, Fabio, Vivarelli, Marco, Wakabayashi, Go, Zanus, Giacomo, Zureikat, Amer, Zyromski, Nicholas J., Coppola, Roberto, D’Andrea, Vito, Davide, José, Dervenis, Christos, Frigerio, Isabella, Konlon, Kevin C., Michelassi, Fabrizio, Montorsi, Marco, Nealon, William, Portolani, Nazario, Sousa Silva, Donzília, Bozzi, Giuseppe, Ferrari, Viviana, Trivella, Maria G., Cameron, John, Clavien, Pierre-Alain, Asbun, Horacio J., Boraschi, Piero, Campani, Daniela, Cappelli, Carla, Cioni, Roberto, Dominici, Massimo, Esposito, Irene, Gambacorta, Maria A, Marciano, Emanuele, Masi, Gianluca, Morganti, Alessio, Mutignani, Massimiliano, Neri, Emanuele, Paiar, Fabiola, Reni, Michele, Rotondo, Maria Isabella, Silvestris, Nicola, Tortora, Giampaolo, Vasile, Enrico, and Volterrani, Duccio
Published: 2024
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25. Probability of lymph node metastases in patients undergoing adequate lymphadenectomy during surgery for intrahepatic cholangiocarcinoma: a retrospective multicenter study

Author: Carlo Sposito, Alessandro Cucchetti, Francesca Ratti, Laura Alaimo, Francesco Ardito, Stefano Di Sandro, Matteo Serenari, Giammauro Berardi, Marianna Maspero, Giuseppe Maria Ettorre, Matteo Cescon, Fabrizio Di Benedetto, Felice Giuliante, Andrea Ruzzenente, Giorgio Ercolani, Luca Aldrighetti, and Vincenzo Mazzaferro
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Introduction Nodal metastases (LNM) are one of the major determinants of prognosis following surgery for intrahepatic cholangiocarcinoma (ICC). Previous studies investigating the correlation between clinical-radiological features and the probability of LNM include patients undergoing inadequate nodal sampling. Aim of this study was to develop a model to predict the risk of LNM in patients undergoing adequate lymphadenectomy using preoperative clinical and radiological features. Methods Patients undergoing radical surgery for ICC with adequate lymphadenectomy at seven Italian Centers between 2000 and 2023 were collected and divided in a derivation and a validation cohort. Logistic regression and dominance analysis were applied in the derivation cohort to identify variables associated with LNM at pathology. The final coefficients were derived from the model having the highest c-statistic in the derivation cohort with the lowest number of variables included (parsimony). The model was then tested in the external validation cohort and the linear predictor was divided into quartiles to generate four risk categories. Results A total of 693 patients were identified. Preoperative Ca19-9, clinically suspicious lymph nodes at radiology, patients’ age and tumour burden score were significantly associated with LNM. These factors were included in a model (https://aicep.website/?cff-form=20) showing a c-statistic of 0.723 (95%CI: 0.680, 0.766) and 0.771 (95%CI: 0.699, 0.842) in the derivation and validation cohort respectively. A progressive increase of pathological lymph node positivity across risk groups was observed (29.9% in low-risk, 45.1% in intermediate-low risk, 51.5% in intermediate-high risk and 87.3% in high-risk patients; p=0.001). Conclusions A novel model that combines preoperative Ca19-9, clinically suspicious lymph nodes at radiology, patients’ age and tumour burden score was developed to predict the risk of lymph node metastasis (LNM) before surgery. The model exhibited high accuracy, and has the potential to assist clinicians in the management of patients who are candidate to surgery.
Published: 2024
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26. A test platform for the detection and readout chain for the Athena X-IFU

Author: Betancourt-Martinez, Gabriele, Pajot, François, Beaumont, Sophie, Roudil, Gilles, Adams, Joseph, Akamatsu, Hiroki, Bandler, Simon, Bertrand, Bernard, Bruijn, Marcel, Castellani, Florent, Cucchetti, Edoardo, Doriese, William, Dupieux, Michel, Geoffray, Hervé, Gottardi, Luciano, Jackson, Brian, van der Kuur, Jan, Kiviranta, Mikko, Miniussi, Antoine, Peille, Phillipe, Ravensberg, Kevin, Ravera, Laurent, Reintsema, Carl, Sakai, Kazuhiro, Smith, Stephen, Wakeham, Nicholas, van Weers, Henk, Wernicke, Doreen, and Witthoeft, Michael
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract: We present a test platform for the Athena X-IFU detection chain, which will serve as the first demonstration of the representative end-to-end detection and readout chain for the X-IFU, using prototypes of the future flight electronics and currently available subsystems. This test bench, housed in a commercial two-stage ADR cryostat, includes a focal plane array placed at the 50 mK cold stage of the ADR with a kilopixel array of transition-edge sensor microcalorimeter spectrometers and associated cold readout electronics. Prototype room temperature electronics for the X-IFU provide the readout, and will evolve over time to become more representative of the X-IFU mission baseline. The test bench yields critical feedback on subsystem designs and interfaces, in particular the warm readout electronics, and will provide an in-house detection system for continued testing and development of the warm readout electronics and for the validation of X-ray calibration sources. In this paper, we describe the test bench subsystems and design, characterization of the cryostat, and current status of the project., Comment: 11 pages, 4 figures, to appear in Proc. SPIE Astronomical Telescopes and Instrumentation, 2020
Published: 2021
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27. Fully covered versus partially covered self-expandable metal stents for palliation of distal malignant biliary obstruction: a systematic review and meta-analysis

Author: Vanella, Giuseppe, Coluccio, Chiara, Cucchetti, Alessandro, Leone, Roberto, Dell’Anna, Giuseppe, Giuffrida, Paolo, Abbatiello, Carmela, Binda, Cecilia, Fabbri, Carlo, and Arcidiacono, Paolo Giorgio
Published: 2024
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28. The X-CLASS survey: A catalogue of 1646 X-ray-selected galaxy clusters up to z$\sim$1.5

Author: Koulouridis, E., Clerc, N., Sadibekova, T., Chira, M., Drigga, E., Faccioli, L., Fèvre, J. P. Le, Garrel, C., Gaynullina, E., Gkini, A., Kosiba, M., Pacaud, F., Pierre, M., Ridl, J., Tazhenova, K., Adami, C., Altieri, B., Baguley, J. -C., Cabanac, R., Cucchetti, E., Khalikova, A., Lieu, M., Melin, J. -B., Molham, M., Ramos-Ceja, M. E., Soucail, G., Takey, A., and Valtchanov, I.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract: Cosmological probes based on galaxy clusters rely on cluster number counts and large-scale structure information. X-ray cluster surveys are well suited for this purpose, since they are far less affected than optical surveys by projection effects, and cluster properties can be predicted with good accuracy. The XMM Cluster Archive Super Survey, X-CLASS, is a serendipitous search of X-ray-detected galaxy clusters in 4176 XMM-Newton archival observations until August 2015. All observations are clipped to exposure times of 10 and 20 ks to obtain uniformity and they span ~269 deg$^2$ across the high-Galactic latitude sky ($|b|> 20^o$). The main goal of the survey is the compilation of a well-selected cluster sample suitable for cosmological analyses. We describe the detection algorithm, the visual inspection, the verification process and the redshift validation of the cluster sample, as well as the cluster selection function computed by simulations. We also present the various metadata that are released with the catalogue, along with the redshifts of 124 clusters obtained with a dedicated multi-object spectroscopic follow-up programme. With this publication we release the new X-CLASS catalogue of 1646 well-selected X-ray-detected clusters over a wide sky area, along with their selection function. The sample spans a wide redshift range, from the local Universe up to z~1.5, with 982 spectroscopically confirmed clusters, and over 70 clusters above z=0.8. Because of its homogeneous selection and thorough verification, the cluster sample can be used for cosmological analyses, but also as a test-bed for the upcoming eROSITA observations and other current and future large-area cluster surveys. It is the first time that such a catalogue is made available to the community via an interactive database which gives access to a wealth of supplementary information, images, and data., Comment: Accepted for publication in A&A
Published: 2021
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29. The i-EUS consensus on the management of pancreatic fluid collections – Part 1

Author: Aragona, Giovanni, Arcidiacono, Paolo Giorgio, Arvanitaki, Marianna, Badas, Roberta, Barresi, Luca, Berretti, Debora, Bocus, Paolo, Camellini, Lorenzo, Cintorino, Davide, Cugia, Luigi, Dabizzi, Emanuele, De Angelis, Claudio Giovanni, Blanco, Giovanna Del Vecchio, Matteo, Francesco Maria Di, Mitri, Roberto Di, Ercolani, Giorgio, Falconi, Massimo, Fantin, Alberto, Ligresti, Dario, Macchiarelli, Raffaele, Mangiafico, Santi, Mangiavillano, Benedetto, Manno, Mauro, Maruzzelli, Luigi, Marzioni, Marco, Pedicini, Vittorio, Piras, Enrico, Pollino, Valeria, Sethi, Amrita, Siddiqui, Uzma, Togliani, Thomas, Traina, Mario, Tringali, Alberto, Venezia, Giovanna, Zerbi, Alessandro, Capurso, Gabriele, Rizzo, Giacomo Emanuele Maria, Coluccio, Chiara, Crinò, Stefano Francesco, Cucchetti, Alessandro, Facciorusso, Antonio, Hassan, Cesare, Amato, Arnaldo, Auriemma, Francesco, Bertani, Helga, Binda, Cecilia, Cipolletta, Fabio, Forti, Edoardo, Fugazza, Alessandro, Lisotti, Andrea, Maida, Marcello, Sinagra, Emanuele, Sbrancia, Monica, Spadaccini, Marco, Tacelli, Matteo, Vanella, Giuseppe, Anderloni, Andrea, Fabbri, Carlo, and Tarantino, Ilaria
Published: 2024
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30. ‘Potentially curative therapies’ for hepatocellular carcinoma: how many patients can actually be cured?

Author: Cucchetti, Alessandro, Elshaarawy, Omar, Han, Guohong, Chong, Charing C. N., Serra, Carla, O’Rourke, Joanne Marie, Crew, Richard, Felicani, Cristina, Ercolani, Giorgio, Shah, Tahir, Vogel, Arndt, Lai, Paul B. S., and Johnson, Philip J.
Published: 2023
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31. Textbook Outcome After Trans-arterial Chemoembolization for Hepatocellular Carcinoma

Author: Mosconi, Cristina, O’Rourke, Joanne, Kloeckner, Roman, Sturm, Lukas, Golfieri, Rita, Celsa, Ciro, Fateen, Waleed, Odisio, Bruno C., Garanzini, Enrico Matteo, Peck-Radosavljevic, Markus, Borghi, Alberto, Ma, Yuk Ting, Stoehr, Fabian, Bettinger, Dominik, Giuffrida, Paolo, Aithal, Guruprasad P., Lin, Yuan-Mao, Spreafico, Carlo, Giampalma, Emanuela, Johnson, Philip, and Cucchetti, Alessandro
Published: 2023
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32. The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase

Author: Barret, Didier, Albouys, Vincent, Herder, Jan-Willem den, Piro, Luigi, Cappi, Massimo, Huovelin, Juhani, Kelley, Richard, Mas-Hesse, J. Miguel, Paltani, Stéphane, Rauw, Gregor, Rozanska, Agata, Svoboda, Jiri, Wilms, Joern, Yamasaki, Noriko, Audard, Marc, Bandler, Simon, Barbera, Marco, Barcons, Xavier, Bozzo, Enrico, Ceballos, Maria Teresa, Charles, Ivan, Costantini, Elisa, Dauser, Thomas, Decourchelle, Anne, Duband, Lionel, Duval, Jean-Marc, Fiore, Fabrizio, Gatti, Flavio, Goldwurm, Andrea, Hartog, Roland den, Jackson, Brian, Jonker, Peter, Kilbourne, Caroline, Korpela, Seppo, Macculi, Claudio, Mendez, Mariano, Mitsuda, Kazuhisa, Molendi, Silvano, Pajot, François, Pointecouteau, Etienne, Porter, Frederick, Pratt, Gabriel W., Prêle, Damien, Ravera, Laurent, Sato, Kosuke, Schaye, Joop, Shinozaki, Keisuke, Skup, Konrad, Soucek, Jan, Thibert, Tanguy, Vink, Jacco, Webb, Natalie, Chaoul, Laurence, Raulin, Desi, Simionescu, Aurora, Torrejon, Jose Miguel, Acero, Fabio, Branduardi-Raymont, Graziella, Ettori, Stefano, Finoguenov, Alexis, Grosso, Nicolas, Kaastra, Jelle, Mazzotta, Pasquale, Miller, Jon, Miniutti, Giovanni, Nicastro, Fabrizio, Sciortino, Salvatore, Yamaguchi, Hiroya, Beaumont, Sophie, Cucchetti, Edoardo, D’Andrea, Matteo, Eckart, Megan, Ferrando, Philippe, Kammoun, Elias, Lotti, Simone, Mesnager, Jean-Michel, Natalucci, Lorenzo, Peille, Philippe, de Plaa, Jelle, Ardellier, Florence, Argan, Andrea, Bellouard, Elise, Carron, Jérôme, Cavazzuti, Elisabetta, Fiorini, Mauro, Khosropanah, Pourya, Martin, Sylvain, Perry, James, Pinsard, Frederic, Pradines, Alice, Rigano, Manuela, Roelfsema, Peter, Schwander, Denis, Torrioli, Guido, Ullom, Joel, Vera, Isabel, Villegas, Eduardo Medinaceli, Zuchniak, Monika, Brachet, Frank, Cicero, Ugo Lo, Doriese, William, Durkin, Malcom, Fioretti, Valentina, Geoffray, Hervé, Jacques, Lionel, Kirsch, Christian, Smith, Stephen, Adams, Joseph, Gloaguen, Emilie, Hoogeveen, Ruud, van der Hulst, Paul, Kiviranta, Mikko, van der Kuur, Jan, Ledot, Aurélien, van Leeuwen, Bert-Joost, van Loon, Dennis, Lyautey, Bertrand, Parot, Yann, Sakai, Kazuhiro, van Weers, Henk, Abdoelkariem, Shariefa, Adam, Thomas, Adami, Christophe, Aicardi, Corinne, Akamatsu, Hiroki, Alonso, Pablo Eleazar Merino, Amato, Roberta, André, Jérôme, Angelinelli, Matteo, Anon-Cancela, Manuel, Anvar, Shebli, Atienza, Ricardo, Attard, Anthony, Auricchio, Natalia, Balado, Ana, Bancel, Florian, Barusso, Lorenzo Ferrari, Bascuñan, Arturo, Bernard, Vivian, Berrocal, Alicia, Blin, Sylvie, Bonino, Donata, Bonnet, François, Bonny, Patrick, Boorman, Peter, Boreux, Charles, Bounab, Ayoub, Boutelier, Martin, Boyce, Kevin, Brienza, Daniele, Bruijn, Marcel, Bulgarelli, Andrea, Calarco, Simona, Callanan, Paul, Campello, Alberto Prada, Camus, Thierry, Canourgues, Florent, Capobianco, Vito, Cardiel, Nicolas, Castellani, Florent, Cheatom, Oscar, Chervenak, James, Chiarello, Fabio, Clerc, Laurent, Clerc, Nicolas, Cobo, Beatriz, Coeur-Joly, Odile, Coleiro, Alexis, Colonges, Stéphane, Corcione, Leonardo, Coriat, Mickael, Coynel, Alexandre, Cuttaia, Francesco, D’Ai, Antonino, D’anca, Fabio, Dadina, Mauro, Daniel, Christophe, Dauner, Lea, DeNigris, Natalie, Dercksen, Johannes, DiPirro, Michael, Doumayrou, Eric, Dubbeldam, Luc, Dupieux, Michel, Dupourqué, Simon, Durand, Jean Louis, Eckert, Dominique, Eiriz, Valvanera, Ercolani, Eric, Etcheverry, Christophe, Finkbeiner, Fred, Fiocchi, Mariateresa, Fossecave, Hervé, Franssen, Philippe, Frericks, Martin, Gabici, Stefano, Gant, Florent, Gao, Jian-Rong, Gastaldello, Fabio, Genolet, Ludovic, Ghizzardi, Simona, Gil, Ma Angeles Alcacera, Giovannini, Elisa, Godet, Olivier, Gomez-Elvira, Javier, Gonzalez, Raoul, Gonzalez, Manuel, Gottardi, Luciano, Granat, Dolorès, Gros, Michel, Guignard, Nicolas, Hieltjes, Paul, Hurtado, Adolfo Jesús, Irwin, Kent, Jacquey, Christian, Janiuk, Agnieszka, Jaubert, Jean, Jiménez, Maria, Jolly, Antoine, Jourdan, Thierry, Julien, Sabine, Kedziora, Bartosz, Korb, Andrew, Kreykenbohm, Ingo, König, Ole, Langer, Mathieu, Laudet, Philippe, Laurent, Philippe, Laurenza, Monica, Lesrel, Jean, Ligori, Sebastiano, Lorenz, Maximilian, Luminari, Alfredo, Maffei, Bruno, Maisonnave, Océane, Marelli, Lorenzo, Massonet, Didier, Maussang, Irwin, Melchor, Alejandro Gonzalo, Le Mer, Isabelle, Millan, Francisco Javier San, Millerioux, Jean-Pierre, Mineo, Teresa, Minervini, Gabriele, Molin, Alexeï, Monestes, David, Montinaro, Nicola, Mot, Baptiste, Murat, David, Nagayoshi, Kenichiro, Nazé, Yaël, Noguès, Loïc, Pailot, Damien, Panessa, Francesca, Parodi, Luigi, Petit, Pascal, Piconcelli, Enrico, Pinto, Ciro, Plaza, Jose Miguel Encinas, Plaza, Borja, Poyatos, David, Prouvé, Thomas, Ptak, Andy, Puccetti, Simonetta, Puccio, Elena, Ramon, Pascale, Reina, Manuel, Rioland, Guillaume, Rodriguez, Louis, Roig, Anton, Rollet, Bertrand, Roncarelli, Mauro, Roudil, Gilles, Rudnicki, Tomasz, Sanisidro, Julien, Sciortino, Luisa, Silva, Vitor, Sordet, Michael, Soto-Aguilar, Javier, Spizzi, Pierre, Surace, Christian, Sánchez, Miguel Fernández, Taralli, Emanuele, Terrasa, Guilhem, Terrier, Régis, Todaro, Michela, Ubertini, Pietro, Uslenghi, Michela, de Vaate, Jan Geralt Bij, Vaccaro, Davide, Varisco, Salvatore, Varnière, Peggy, Vibert, Laurent, Vidriales, María, Villa, Fabrizio, Vodopivec, Boris Martin, Volpe, Angela, de Vries, Cor, Wakeham, Nicholas, Walmsley, Gavin, Wise, Michael, de Wit, Martin, and Woźniak, Grzegorz
Published: 2023
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33. Fluorescence Cholangiography Using Indocyanine Green Improves the Identification of Biliary Structures During Laparoscopic Cholecystectomy

Author: D’Acapito, Fabrizio, Cucchetti, Alessandro, Solaini, Leonardo, Serenari, Matteo, Framarini, Massimo, and Ercolani, Giorgio
Published: 2023
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34. Constraining the origin and models of chemical enrichment in galaxy clusters using the Athena X-IFU

Author: Mernier, F., Cucchetti, E., Tornatore, L., Biffi, V., Pointecouteau, E., Clerc, N., Peille, P., Rasia, E., Barret, D., Borgani, S., Bulbul, E., Dauser, T., Dolag, K., Ettori, S., Gaspari, M., Pajot, F., Roncarelli, M., Wilms, J., and Noûs, C.
Subjects: Astrophysics - Astrophysics of Galaxies, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The chemical enrichment of the Universe at all scales is related to stellar winds and explosive supernovae phenomena. Metals produced by stars and later spread at the mega-parsec scale through the intra-cluster medium (ICM) become a fossil record of the chemical enrichment of the Universe and of the dynamical and feedback mechanisms determining their circulation. As demonstrated by the results of the soft X-ray spectrometer onboard Hitomi, high resolution X-ray spectroscopy is the path to to differentiate among the models that consider different metal production mechanisms, predict the outcoming yields, and are function of the nature, mass, and/or initial metallicity of their stellar progenitor. Transformational results shall be achieved through improvements in the energy resolution and effective area of X-ray observatories to detect rare metals (e.g. Na, Al) and constrain yet uncertain abundances (e.g. C, Ne, Ca, Ni). The X-ray Integral Field Unit (X-IFU) instrument onboard the next-generation European X-ray observatory Athena is expected to deliver such breakthroughs. Starting from 100 ks of synthetic observations of 12 abundance ratios in the ICM of four simulated clusters, we demonstrate that the X-IFU will be capable of recovering the input chemical enrichment models at both low ($z = 0.1$) and high ($z = 1$) redshifts, while statistically excluding more than 99.5% of all the other tested combinations of models. By fixing the enrichment models which provide the best fit to the simulated data, we also show that the X-IFU will constrain the slope of the stellar initial mass function within $\sim$12%. These constraints will be key ingredients in our understanding of the chemical enrichment of the Universe and its evolution., Comment: 17 pages, 6 figures, accepted for publication in A&A
Published: 2020
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35. The origins of the Reference: analysis and development of the service

Author: Paolo Cucchetti
Subjects: history of libraries, reference service, public libraries, university libraries, special libraries, Bibliography. Library science. Information resources
Abstract: This paper analyzes the origins and development of the reference service and how it has become the most important practice within libraries. Through a historical investigation that begins in the second half of the nineteenth century and continues beyond the middle of the twentieth century, the diffusion of this activity in its various components and ramifications is outlined, focusing on the application differences present in the various types of library institutions. The research analyzes the causes that led to the birth of this activity, which has completely revolutionized the way of perceiving libraries and their work. Using the sources of the main authors who have dealt with this topic, it is possible to understand the growth of the concept of “assistance” towards readers, its various extensions and above all the consequences that these ideas had on the evolution of the image of libraries within the society.
Published: 2023
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36. Alarming correlation between multidrug-resistant bacteriobilia and morbidity after pancreatic surgery

Author: Gibiino, Giulia, Cucchetti, Alessandro, Mocchegiani, Federico, Bocchino, Antonio, Gaudenzi, Federico, Binda, Cecilia, Raumer, Luigi, Fabbri, Carlo, Cristini, Francesco, Vivarelli, Marco, and Ercolani, Giorgio
Published: 2023
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37. European’ health care indicators and pancreatic cancer incidence and mortality: A mediation analysis of Eurostat data and Global Burden of Disease Study 2019

Author: Cucchetti, Alessandro, Johnson, Philip, Capurso, Gabriele, Crippa, Stefano, Pacilio, Carlo Alberto, Fabbri, Carlo, Falconi, Massimo, and Ercolani, Giorgio
Published: 2023
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38. Survival benefit of second line therapies for recurrent hepatocellular carcinoma: repeated hepatectomy, thermoablation and second-line transplant referral in a real life national scenario

Author: Milana, Flavio, Bertacco, Alessandra, De Carlis, Riccardo, Ratti, Francesca, Russolillo, Nadia, Iaria, Maurizio, Razionale, Francesco, Tartaglia, Giuseppe, Ciulli, Cristina, Carissimi, Francesca, Laureiro, Zoe L., Marinelli, Laura, DePeppo, Valerio, Montuori, Mauro, Marchitelli, Ivan, Franceschi, Angelo, Notte, Francesca, Manzoni, Alberto, Cosola, Davide, Corleone, Pio, Fumagalli, Luca, Salvador, Luca, Mantovani, Guido, Cucchetti, Alessandro, Cammarata, Francesco, Conticchio, Maria, Patrone, Renato, Bernasconi, Davide P., Famularo, Simone, Cillo, Umberto, Lauterio, Andrea, Donadon, Matteo, Vitale, Alessandro, Serenari, Matteo, Cipriani, Federica, Fazio, Federico, Giuffrida, Mario, Ardito, Francesco, Dominioni, Tommaso, Garancini, Mattia, Lai, Quirino, Nicolini, Daniele, Molfino, Sarah, Perri, Pasquale, Pinotti, Enrico, Conci, Simone, Ferrari, Cecilia, Zanello, Matteo, Patauner, Stefan, Zimmitti, Giuseppe, Germani, Paola, Chiarelli, Marco, Romano, Maurizio, De Angelis, Michela, La Barba, Giuliano, Troci, Albert, Ferraro, Valentina, Izzo, Francesco, Antonucci, Adelmo, Belli, Andrea, Memeo, Riccardo, Crespi, Michele, Ercolani, Giorgio, Boccia, Luigi, Zanus, Giacomo, Tarchi, Paola, Hilal, Moh'd Abu, Frena, Antonio, Jovine, Elio, Griseri, Guido, Ruzzenente, Andrea, Zago, Mauro, Grazi, Gianluca, Baiocchi, Gian L., Vivarelli, Marco, Rossi, Massimo, Romano, Fabrizio, Maestri, Marcello, Giuliante, Felice, Valle, Raffaele D., Ferrero, Alessandro, Aldrighetti, Luca, De Carlis, Luciano, Cescon, Matteo, and Torzilli, Guido
Published: 2023
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39. Implementation of a patient blood management in an Italian City Hospital: is it effective in reducing the use of red blood cells?

Author: Ercolani, Giorgio, Solaini, Leonardo, D’Acapito, Fabrizio, Isopi, Claudio, Pacilio, Carlo Alberto, Moretti, Cinzia, Agostini, Vanessa, and Cucchetti, Alessandro
Published: 2023
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40. The Athena X-IFU Instrument Simulator xifusim

Author: Kirsch, C., Lorenz, M., Peille, P., Dauser, T., Ceballos, M. T., Cobo, B., Merino-Alonso, P. E., Cucchetti, E., Smith, S. J., Gottardi, L., Hartog, R. H. den, Miniussi, A., Durkin, M., Prêle, D., and Wilms, J.
Published: 2022
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41. SIXTE -- The Generic X-ray Instrument Simulation Toolkit

Author: Dauser, Thomas, Falkner, Sebastian, Lorenz, Maximilian, Kirsch, Christian, Peille, Philippe, Cucchetti, Edoardo, Schmid, Christian, Brand, Thorsten, Oertel, Mirjam, Smith, Randall, and Wilms, Jörn
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: We give an overview of the SImulation of X-ray TElescopes (SIXTE) software package, a generic, mission-independent Monte Carlo simulation toolkit for X-ray astronomical instrumentation. The package is based on a modular approach for the source definition, the description of the optics, and the detector type such that new missions can be easily implemented. The targets to be simulated are stored in a flexible input format called SIMPUT. Based on this source definition, a sample of photons is produced and then propagated through the optics. In order to model the detection process, the software toolkit contains modules for various detector types, ranging from proportional counter and Si-based detectors, to more complex descriptions like transition edge sensor (TES) devices. The implementation of characteristic detector effects and a detailed modeling of the read-out process allow for representative simulations and therefore enable the analysis of characteristic features, such as for example pile-up, and their impact on observations. We present an overview of the implementation of SIXTE from the input source, the imaging, and the detection process, highlighting the modular approach taken by the SIXTE software package. In order to demonstrate the capabilities of the simulation software, we present a selection of representative applications, including the all-sky survey of eROSITA and a study of pile-up effects comparing the currently operating XMM-Newton with the planned Athena-WFI instrument. A simulation of a galaxy cluster with the Athena- X-IFU shows the capability of SIXTE to predict the expected performance of an observation for a complex source with a spatially varying spectrum and our current knowledge of the future instrument., Comment: accepted for publication in A&A
Published: 2019
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42. Personalised management of patients with hepatocellular carcinoma: a multiparametric therapeutic hierarchy concept

Author: Baccarani, Umberto, Brancaccio, Giuseppina, Cozzolongo, Raffaele, Cucchetti, Alessandro, De Matthaeis, Nicoletta, Di Sandro, Stefano, Famularo, Simone, Finotti, Michele, Foschi, Francesco G, Ghinolfi, Davide, Guarracino, Marco, Gruttadauria, Salvatore, Guarino, Maria, Kostandini, Alba, Lenci, Ilaria, Levi Sandri, Giovanni B, Manzia, Tommaso M, Marasco, Giovanni, Masarone, Mario, Mazzarelli, Chiara, Melandro, Fabio, Miele, Luca, Morisco, Filomena, Nicolini, Daniele, Pagano, Duilio, Pelizzaro, Filippo, Pieri, Giulia, Piscaglia, Fabio, Plaz Torres, Maria Corina, Pravisani, Riccardo, Rendina, Maria, Romano, Fabrizio, Russo, Francesco P, Sacco, Rodolfo, Sangiovanni, Angelo, Sposito, Carlo, Tortora, Raffaella, Tovoli, Francesco, Viganò, Mauro, Violi, Paola, Vitale, Alessandro, Cabibbo, Giuseppe, Iavarone, Massimo, Viganò, Luca, Pinato, David J, Ponziani, Francesca Romana, Lai, Quirino, Casadei-Gardini, Andrea, Celsa, Ciro, Galati, Giovanni, Gambato, Martina, Crocetti, Laura, Renzulli, Matteo, Giannini, Edoardo G, Farinati, Fabio, Trevisani, Franco, and Cillo, Umberto
Published: 2023
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43. Towards mapping turbulence in the intra-cluster medium -- I. Sample variance in spatially-resolved X-ray line diagnostics

Author: Clerc, N., Cucchetti, E., Pointecouteau, E., and Peille, P.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: X-ray observations of galaxy clusters provide insights on the nature of gaseous turbulent motions, their physical scales and on the fundamental processes they are related to. Spatially-resolved, high-resolution spectral measurements of X-ray emission lines provide diagnostics on the nature of turbulent motions in emitting atmospheres. Since they are acting on scales comparable to the size of the objects, the uncertainty on these physical parameters is limited by the number of observational measurements, through sample variance. We propose a different and complementary approach for the computation of sample variance to repeating numerical simulations (i.e. Monte-Carlo sampling) by introducing new analytical developments for lines diagnosis. We consider the model of a "turbulent gas cloud", consisting in isotropic and uniform turbulence described by a universal Kolmogorov power-spectrum with random amplitudes and phases in an optically thin medium. Following a simple prescription for the 4-term correlation of Fourier coefficients, we derive generic expressions for the sample mean and variance of line centroid shift, line broadening and projected velocity structure function. We perform a numerical validation based on Monte-Carlo simulations for two popular models of gas emissivity based on the beta-model. Generic expressions for the sample variance of line centroid shifts and broadening in arbitrary apertures are derived and match the simulations within their range of applicability. Generic expressions for the mean and variance of the structure function are provided and verified against simulations. An application to the Athena/X-IFU and XRISM/Resolve instruments forecasts the potential of sensitive, spatially-resolved spectroscopy to probe the inertial range of turbulent velocity cascades in a Coma-like galaxy cluster., Comment: 15 pages, 28 figures, 8 appendices. Accepted for publication in Astronomy & Astrophysics
Published: 2019
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44. Towards mapping turbulence in the intra-cluster medium -- II. Measurement uncertainties in the estimation of structure functions

Author: Cucchetti, E., Clerc, N., Pointecouteau, E., Peille, P., and Pajot, F.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: X-ray observations of the hot gas filling the intra-cluster medium provide a wealth of information on the dynamics of clusters of galaxies. The global equilibrium of the ICM is believed to be partially ensured by non-thermal pressure support, notably the dissipation of energy through turbulent motions. Accurate mapping of turbulence using X-ray emission lines is challenging due to the lack of spatially-resolved spectroscopy. Only future instruments such as the X-ray Integral Field Unit (X-IFU) on Athena will have the spatial and spectral resolution to quantitatively investigate the ICM turbulence at all scales. Powerful diagnostics for these studies are line shift and the line broadening maps, and the second-order structure function. When estimating these quantities, instruments will be limited by uncertainties of their measurements, and by the sample variance (aka cosmic variance) of the observation. We extend here the formalism started in our companion paper I to include the effect of statistical uncertainties in the estimation of these line diagnostics, in particular for structure functions. We demonstrate that statistics contribute to the total variance through different terms, which depend on the geometry of the detector, the spatial binning and the nature of the turbulent field. These terms are important when probing the small scales of the turbulence. An application of these equations is performed for the X-IFU, using synthetic turbulent velocity maps of a Coma-like cluster of galaxies. Results are in excellent agreement with the formulas both for the structure function estimation (<3%) and its variance (<10%). The expressions derived here and in paper I are generic, and ensure an estimation of the total errors in any X-ray measurement of turbulent structure functions. They also open the way for optimisations in the upcoming instrumentation and in observational strategies., Comment: 14 pages, 5 figures, 1 appendix. Accepted for publication in Astronomy & Astrophysics
Published: 2019
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45. Probing Macro-Scale Gas Motions and Turbulence in Diffuse Cosmic Plasmas

Author: Bulbul, Esra, Gaspari, Massimo, Alvarez, Gabriella, Avestruz, Camille, Bautz, Mark, Benson, Brad, Biffi, Veronica, Burke, Douglas, Clerc, Nicolas, Chadayammuri, Urmila, Churazov, Eugene, Cucchetti, Edoardo, Eckert, Dominique, Ettori, Stefano, Forman, Bill, Gastaldello, Fabio, Ghirardini, Vittorio, Kraft, Ralph, Markevitch, Maxim, McDonald, Mike, Miller, Eric, Mroczkowski, Tony, Nagai, Daisuke, Nulsen, Paul, Pratt, Gabriel W., Randall, Scott, Reiprich, Thomas, Roncarelli, Mauro, Simionescu, Aurora, Smith, Randall, Tremblay, Grant, Walker, Stephen, Zhuravleva, Irina, and ZuHone, John
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Clusters of galaxies, the largest collapsed structures in the Universe, are located at the intersection of extended filaments of baryons and dark matter. Cosmological accretion onto clusters through large scale filaments adds material at cluster outskirts. Kinetic energy in the form of bulk motions and turbulence due to this accretion provides a form of pressure support against gravity, supplemental to thermal pressure. Significant amount of non-thermal pressure support could bias cluster masses derived assuming hydrostatic equilibrium, the primary proxy for cluster cosmology studies. Sensitive measurements of Doppler broadening and shift of astrophysical lines, and the relative fluctuations in thermodynamical quantities (e.g., density, pressure, and entropy) are primary diagnostic tools. Forthcoming planned and proposed X-ray (with large etendue, throughput, and high spectral resolution) and SZ observatories will provide crucial information on the assembly and virialisation processes of clusters, involving turbulent eddies cascading at various spatial scales and larger gas bulk motions in their external regions to the depth or their potential wells., Comment: 5 pages, 3 figures, Science white paper submitted to the Astro2020 Decadal Survey
Published: 2019

46. Regret affects the choice between neoadjuvant therapy and upfront surgery for potentially resectable pancreatic cancer

Author: Alfieri, Sergio, Amato, Arnaldo, Amisano, Marco, Anderloni, Andrea, Maestri, Antonio, Coluccio, Chiara, Brandi, Giovanni, Casadei-Gardini, Andrea, Cennamo, Vincenzo, Crinò, Stefano Francesco, Valle, Raffaele Dalla, De Angelis, Claudio, Di Battista, Monica, Di Maio, Massimo, Di Marco, Mariacristina, Di Marco, Marco, Di Matteo, Francesco, Di Mitri, Roberto, Ettorre, Giuseppe Maria, Facciorusso, Antonio, Farina, Gabriella, Ferrari, Giovanni, Fornaro, Lorenzo, Frigerio, Isabella, Frisone, Daniele, Fuccio, Lorenzo, Gardini, Andrea, Garufi, Carlo, Giampieri, Riccardo, Grazi, Gian Luca, Jovine, Elio, Kauffmann, Emanuele, Langella, Serena, Larghi, Alberto, Manno, Mauro, Marciano, Emanuele, Marzioni, Marco, Merighi, Alberto, Mutignani, Massimiliano, Nardo, Bruno, Niger, Monica, Palmisano, Valentina, Partelli, Stefano, Pinto, Carmine, Piras, Enrico, Rapposelli, Ilario Giovanni, Reni, Michele, Ricci, Claudio, Rimassa, Lorenza, Siena, Salvatore, Spada, Cristiano, Sperti, Elisa, Spezzaferro, Mariangela, Sposito, Carlo, Tamberi, Stefano, Troisi, Roberto, Veneroni, Luigi, Vivarelli, Marco, Zerbi, Alessandro, Cucchetti, Alessandro, Djulbegovic, Benjamin, Crippa, Stefano, Hozo, Iztok, Sbrancia, Monica, Tsalatsanis, Athanasios, Binda, Cecilia, Fabbri, Carlo, Salvia, Roberto, Falconi, Massimo, and Ercolani, Giorgio
Published: 2023
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47. Determinants of outcomes of transmural EUS-guided gallbladder drainage: systematic review with proportion meta-analysis and meta-regression

Author: Fabbri, Carlo, Binda, Cecilia, Sbrancia, Monica, Dajti, Elton, Coluccio, Chiara, Ercolani, Giorgio, Anderloni, Andrea, and Cucchetti, Alessandro
Published: 2022
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48. Risk factors and scores for prediction of coronary artery aneurysms in Kawasaki disease: a European monocentric study

Author: La Vecchia, A, Stracquadaino, R, Mauri, L, Baselli, L, Abdallah, R, Cucchetti, M, Colli, A, Agostoni, C, Dellepiane, R, La Vecchia, Adriano, Stracquadaino, Rita, Mauri, Lucia, Baselli, Lucia Augusta, Abdallah, Rozan, Cucchetti, Martina, Colli, Anna Maria, Agostoni, Carlo, Dellepiane, Rosa Maria, La Vecchia, A, Stracquadaino, R, Mauri, L, Baselli, L, Abdallah, R, Cucchetti, M, Colli, A, Agostoni, C, Dellepiane, R, La Vecchia, Adriano, Stracquadaino, Rita, Mauri, Lucia, Baselli, Lucia Augusta, Abdallah, Rozan, Cucchetti, Martina, Colli, Anna Maria, Agostoni, Carlo, and Dellepiane, Rosa Maria
Abstract: Background: Japanese Kawasaki disease (KD) risk scores cannot be adopted in non-Japanese patients. In North American populations a baseline coronary artery Z-score > 2 and the Son score are associated with coronary artery aneurysms (CAAs) at 4 and 8 weeks from disease onset. In European populations, the Kawanet and Kawanet-echo scores are associated with intravenous immunoglobulin resistance. This study aims to evaluate the association between KD risk scores and baseline coronary artery Z-scores with CAAs at one, two, and six months in a European population. Methods: Historical cohort study of all the children diagnosed with KD in a tertiary care hospital in Milan, Italy, between 1st January 2015 and 31st May 2021. Univariate and multivariate (adjusting for age and corticosteroid therapy) logistic regression analyses were used to study the association between the risk scores, a baseline Z-score ≥ 2 and ≥ 2.5 with CAAs. Results: Eighty-nine patients were diagnosed with KD at our Centre, and 12 were excluded based on the exclusion criteria. We included 77 patients, 51 (66%) males, and 26 (34%) females, with a median age at presentation of 27 months (IQR 13–46). A baseline Z-score ≥ 2 was correlated with CAAs at one and two-month follow-ups (odds ratio (OR) 10, 95% confidence interval (CI) 2–72, and OR 18, CI 3-357) but not at six-month follow-up. The Son score showed an association with one and two-month follow-up CAAs (OR 3, CI 1.3-7, and OR 3, CI 1.3-8) but not with a six-month follow-up. Conclusions: Patients with a baseline Z-score ≥ 2 are at higher risk for CAAs in the long term. The Son score should be tested in larger European samples. Further studies should keep the observational periods longer than 8 weeks from KD onset.
Published: 2024

49. Image Quality of Spectral Filter Arrays for Planetary Rover Applications: From Demosaicing to Color Correction.

Author: Edoardo Cucchetti, Emilie Robert, Alexandre Delahaye, Mathieu Boutillier, Christophe Latry, Karine Mathieu, Nicolas Théret, and Cédric Virmontois
Published: 2022
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50. Hue-specific Color Correction for Raw-RGB Images.

Author: Emilie Robert, Magali Estribeau, Cédric Virmontois, Pierre Magnan, Justin Plantier, and Edoardo Cucchetti
Published: 2022
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