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3. Etrinabdione (VCE-004.8), a B55a activator, promotes angiogenesis and arteriogenesis in critical limb ischemia.

Author

Garcia-Martin, Adela, primary, Prados, Maria E, additional, Lastres-Cubillo, Isabel, additional, Ponce-Diaz-Martin, Francisco J, additional, Cerero, Laura, additional, Garrido-Rodriguez, Martin, additional, Navarrete, Carmen, additional, Pineda, Rafael, additional, Rodriguez, Ana B, additional, Munoz, Ignacio, additional, Moya, Javier, additional, Medeot, Antonella, additional, Moreno, Jose A, additional, Chacon, Antonio, additional, Garcia-Revillo, Jose, additional, and Munoz, Eduardo, additional

Published
2024
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5. Legends from Remission of Spontaneous Canine Tumors after Systemic Cellular Viroimmunotherapy

Author

Cejalvo, Teresa, primary, Perisé-Barrios, Ana Judith, primary, del Portillo, Isabel, primary, Laborda, Eduardo, primary, Rodriguez-Milla, Miguel A., primary, Cubillo, Isabel, primary, Vázquez, Fernando, primary, Sardón, David, primary, Ramirez, Manuel, primary, Alemany, Ramon, primary, del Castillo, Noemí, primary, and García-Castro, Javier, primary

Published
2023
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6. Table S1 from Remission of Spontaneous Canine Tumors after Systemic Cellular Viroimmunotherapy

Author

Cejalvo, Teresa, primary, Perisé-Barrios, Ana Judith, primary, del Portillo, Isabel, primary, Laborda, Eduardo, primary, Rodriguez-Milla, Miguel A., primary, Cubillo, Isabel, primary, Vázquez, Fernando, primary, Sardón, David, primary, Ramirez, Manuel, primary, Alemany, Ramon, primary, del Castillo, Noemí, primary, and García-Castro, Javier, primary

Published
2023
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7. Data from Remission of Spontaneous Canine Tumors after Systemic Cellular Viroimmunotherapy

Author

Cejalvo, Teresa, primary, Perisé-Barrios, Ana Judith, primary, del Portillo, Isabel, primary, Laborda, Eduardo, primary, Rodriguez-Milla, Miguel A., primary, Cubillo, Isabel, primary, Vázquez, Fernando, primary, Sardón, David, primary, Ramirez, Manuel, primary, Alemany, Ramon, primary, del Castillo, Noemí, primary, and García-Castro, Javier, primary

Published
2023
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8. Figure S4 from Remission of Spontaneous Canine Tumors after Systemic Cellular Viroimmunotherapy

Author

Cejalvo, Teresa, primary, Perisé-Barrios, Ana Judith, primary, del Portillo, Isabel, primary, Laborda, Eduardo, primary, Rodriguez-Milla, Miguel A., primary, Cubillo, Isabel, primary, Vázquez, Fernando, primary, Sardón, David, primary, Ramirez, Manuel, primary, Alemany, Ramon, primary, del Castillo, Noemí, primary, and García-Castro, Javier, primary

Published
2023
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9. Differences in Expression of IQSEC2 Transcript Isoforms in Male and Female Cases with Loss of Function Variants and Neurodevelopmental Disorder

Author

Baladron, Beatriz, primary, Mielu, Lidia M., additional, López-Martín, Estrella, additional, Barrero, Maria J., additional, Lopez, Lidia, additional, Alvarado, Jose I., additional, Monzón, Sara, additional, Varona, Sarai, additional, Cuesta, Isabel, additional, Cazorla, Rosario, additional, Lara, Julián, additional, Iglesias, Gemma, additional, Román, Enriqueta, additional, Ros, Purificación, additional, Gomez-Mariano, Gema, additional, Cubillo, Isabel, additional, Miguel, Esther Hernandez-San, additional, Rivera, Daniel, additional, Alonso, Javier, additional, Bermejo-Sánchez, Eva, additional, Posada, Manuel, additional, and Martínez-Delgado, Beatriz, additional

Published
2022
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11. Corrigendum: H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells

Author

Fernández, Agustín F., primary, Bayón, Gustavo F., additional, Urdinguio, Rocío G., additional, Toraño, Estela G., additional, García, María G., additional, Carella, Antonella, additional, Petrus-Reurer, Sandra, additional, Ferrero, Cecilia, additional, Martinez-Camblor, Pablo, additional, Cubillo, Isabel, additional, García-Castro, Javier, additional, Delgado-Calle, Jesús, additional, Pérez-Campo, Flor M., additional, Riancho, José A., additional, Bueno, Clara, additional, Menéndez, Pablo, additional, Mentink, Anouk, additional, Mareschi, Katia, additional, Claire, Fabian, additional, Fagnani, Corrado, additional, Medda, Emanuela, additional, Toccaceli, Virgilia, additional, Brescianini, Sonia, additional, Moran, Sebastián, additional, Esteller, Manel, additional, Stolzing, Alexandra, additional, de Boer, Jan, additional, Nisticò, Lorenza, additional, Stazi, Maria A., additional, and Fraga, Mario F., additional

Published
2019
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12. Remission of Spontaneous Canine Tumors after Systemic Cellular Viroimmunotherapy

Author

Cejalvo, Teresa, primary, Perisé-Barrios, Ana Judith, additional, del Portillo, Isabel, additional, Laborda, Eduardo, additional, Rodriguez-Milla, Miguel A., additional, Cubillo, Isabel, additional, Vázquez, Fernando, additional, Sardón, David, additional, Ramirez, Manuel, additional, Alemany, Ramon, additional, del Castillo, Noemí, additional, and García-Castro, Javier, additional

Published
2018
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13. MOESM9 of Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells

Author

Toraño, Estela, Bayón, Gustavo, Real, Álvaro, Sierra, Marta, García, María, Carella, Antonella, Belmonte, Thalia, Urdinguio, Rocío, Cubillo, Isabel, García-Castro, Javier, Delgado-Calle, Jesús, Pérez-Campo, Flor, Riancho, José, Fraga, Mario, and Fernández, Agustín

Abstract

Additional file 9: Figure S1. Venn diagram showing the overlap of 5mC and 5hmC differentially hyper- and hypohydroxymethylated CpG sites at promoters (left panel), and in CGIs (right panel).

Published
2016
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14. Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells

Author

Instituto de Salud Carlos III, Fundación Ramón Areces, Principado de Asturias, Comunidad de Madrid, European Commission, Fundación Científica Asociación Española Contra el Cáncer, Obra Social Cajastur, Toraño, Estela G., Bayón, Gustavo F., Real, Álvaro del, Sierra, Marta I., García, María G., Carella, Antonella, Belmonte, Thalia, Urdinguio, Rocío G., Cubillo, Isabel, García-Castro, Javier, Delgado-Calle, Jesús, Pérez-Campo, Flor Maria, Riancho, José A., Fraga, Mario F., Fernández, Agustín F., Instituto de Salud Carlos III, Fundación Ramón Areces, Principado de Asturias, Comunidad de Madrid, European Commission, Fundación Científica Asociación Española Contra el Cáncer, Obra Social Cajastur, Toraño, Estela G., Bayón, Gustavo F., Real, Álvaro del, Sierra, Marta I., García, María G., Carella, Antonella, Belmonte, Thalia, Urdinguio, Rocío G., Cubillo, Isabel, García-Castro, Javier, Delgado-Calle, Jesús, Pérez-Campo, Flor Maria, Riancho, José A., Fraga, Mario F., and Fernández, Agustín F.

Abstract

[Background]: Age-associated changes in genomic DNA methylation have been primarily attributed to 5-methylcytosine (5mC). However, the recent discovery of 5-hydroxymethylcytosine (5hmC) suggests that this epigenetic mark might also play a role in the process. [Methods]: Here, we analyzed the genome-wide profile of 5hmc in mesenchymal stem cells (MSCs) obtained from bone-marrow donors, aged 2-89 years. [Results]: We identified 10,685 frequently hydroxymethylated CpG sites in MSCs that were, as in other cell types, significantly associated with low density CpG regions, introns, the histone posttranslational modification H3k4me1 and enhancers. Study of the age-associated changes to 5hmC identified 785 hyper- and 846 hypo-hydroxymethylated CpG sites in the MSCs obtained from older individuals. [Conclusions]: DNA hyper-hydroxymethylation in the advanced-age group was associated with loss of 5mC, which suggests that, at specific CpG sites, this epigenetic modification might play a role in DNA methylation changes during lifetime. Since bone-marrow MSCs have many clinical applications, and the fact that the epigenomic alterations in this cell type associated with aging identified in this study could have associated functional effects, the age of donors should be taken into account in clinical settings.

Published
2016

15. Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells

Author

Toraño, Estela G., primary, Bayón, Gustavo F., additional, del Real, Álvaro, additional, Sierra, Marta I., additional, García, María G., additional, Carella, Antonella, additional, Belmonte, Thalia, additional, Urdinguio, Rocío G., additional, Cubillo, Isabel, additional, García-Castro, Javier, additional, Delgado-Calle, Jesús, additional, Pérez-Campo, Flor M., additional, Riancho, José A., additional, Fraga, Mario F., additional, and Fernández, Agustín F., additional

Published
2016
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16. H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells

Author

Fernández, Agustín F., primary, Bayón, Gustavo F., additional, Urdinguio, Rocío G., additional, Toraño, Estela G., additional, García, María G., additional, Carella, Antonella, additional, Petrus-Reurer, Sandra, additional, Ferrero, Cecilia, additional, Martinez-Camblor, Pablo, additional, Cubillo, Isabel, additional, García-Castro, Javier, additional, Delgado-Calle, Jesús, additional, Pérez-Campo, Flor M., additional, Riancho, José A., additional, Bueno, Clara, additional, Menéndez, Pablo, additional, Mentink, Anouk, additional, Mareschi, Katia, additional, Claire, Fabian, additional, Fagnani, Corrado, additional, Medda, Emanuela, additional, Toccaceli, Virgilia, additional, Brescianini, Sonia, additional, Moran, Sebastián, additional, Esteller, Manel, additional, Stolzing, Alexandra, additional, de Boer, Jan, additional, Nisticò, Lorenza, additional, Stazi, Maria A., additional, and Fraga, Mario F., additional

Published
2014
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19. H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells

Author

Ferníández, Agustín F., Bayíáón, Gustavo F., Urdinguio, Rocíáóío G., Toraíáóíño, Estela G., Garcíáóíñíía, Maríáóíñía G., Carella, Antonella, Petrus-Reurer, Sandra, Ferrero, Cecilia, Martinez-Camblor, Pablo, Cubillo, Isabel, Garcíáóíñííía-Castro, Javier, Delgado-Calle, Jesíáóíñíííús, Píáóíñíííúérez-Campo, Flor M., Riancho, Josíáóíñíííúéé A., Bueno, Clara, Meníáóíñíííúéééndez, Pablo, Mentink, Anouk, Mareschi, Katia, Claire, Fabian, Fagnani, Corrado, Medda, Emanuela, Toccaceli, Virgilia, Brescianini, Sonia, Moran, Sebastiíáóíñíííúéééán, Esteller, Manel, Stolzing, Alexandra, de Boer, Jan, Nisticíáóíñíííúéééáò, Lorenza, Stazi, Maria A., and Fraga, Mario F.

Abstract

In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone post-translational modifications. However, the chromatin marks associated with changes in DNA methylation in adult stem cells during lifetime are still largely unknown. Here, DNA methylation profiling of mesenchymal stem cells (MSCs) obtained from individuals aged 2 to 92 yr identified 18,735 hypermethylated and 45,407 hypomethylated CpG sites associated with aging. As in differentiated cells, hypermethylated sequences were enriched in chromatin repressive marks. Most importantly, hypomethylated CpG sites were strongly enriched in the active chromatin mark H3K4me1 in stem and differentiated cells, suggesting this is a cell type–independent chromatin signature of DNA hypomethylation during aging. Analysis of scedasticity showed that interindividual variability of DNA methylation increased during aging in MSCs and differentiated cells, providing a new avenue for the identification of DNA methylation changes over time. DNA methylation profiling of genetically identical individuals showed that both the tendency of DNA methylation changes and scedasticity depended on nongenetic as well as genetic factors. Our results indicate that the dynamics of DNA methylation during aging depend on a complex mixture of factors that include the DNA sequence, cell type, and chromatin context involved and that, depending on the locus, the changes can be modulated by genetic and/or external factors.

Published
2015
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20. H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells.

Author

Fernández AF, Bayón GF, Urdinguio RG, Toraño EG, García MG, Carella A, Petrus-Reurer S, Ferrero C, Martinez-Camblor P, Cubillo I, García-Castro J, Delgado-Calle J, Pérez-Campo FM, Riancho JA, Bueno C, Menéndez P, Mentink A, Mareschi K, Claire F, Fagnani C, Medda E, Toccaceli V, Brescianini S, Moran S, Esteller M, Stolzing A, de Boer J, Nisticò L, Stazi MA, and Fraga MF

Subjects
Adolescent, Aged, Aged, 80 and over, Cell Differentiation, Cells, Cultured, Child, Child, Preschool, Chromatin genetics, Epigenesis, Genetic, Histones genetics, Humans, Microarray Analysis, Middle Aged, Promoter Regions, Genetic, Protein Processing, Post-Translational, Sequence Analysis, DNA, Twins, Monozygotic, Young Adult, Aging genetics, DNA genetics, DNA Methylation, Stem Cells cytology
Abstract

In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone post-translational modifications. However, the chromatin marks associated with changes in DNA methylation in adult stem cells during lifetime are still largely unknown. Here, DNA methylation profiling of mesenchymal stem cells (MSCs) obtained from individuals aged 2 to 92 yr identified 18,735 hypermethylated and 45,407 hypomethylated CpG sites associated with aging. As in differentiated cells, hypermethylated sequences were enriched in chromatin repressive marks. Most importantly, hypomethylated CpG sites were strongly enriched in the active chromatin mark H3K4me1 in stem and differentiated cells, suggesting this is a cell type-independent chromatin signature of DNA hypomethylation during aging. Analysis of scedasticity showed that interindividual variability of DNA methylation increased during aging in MSCs and differentiated cells, providing a new avenue for the identification of DNA methylation changes over time. DNA methylation profiling of genetically identical individuals showed that both the tendency of DNA methylation changes and scedasticity depended on nongenetic as well as genetic factors. Our results indicate that the dynamics of DNA methylation during aging depend on a complex mixture of factors that include the DNA sequence, cell type, and chromatin context involved and that, depending on the locus, the changes can be modulated by genetic and/or external factors., (© 2015 Fernández et al.; Published by Cold Spring Harbor Laboratory Press.)

Published
2015
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