1. High Prevalence of Anal Human Papillomavirus–Associated Cancer Precursors in a Contemporary Cohort of Asymptomatic HIV-Infected Women
- Author
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Heard, Isabelle, Etienney, Isabelle, Potard, Valérie, Poizot-Martin, Isabelle, Moore, Catherine, Lesage, Anne-Carole, Ressiot, Emmanuelle, Crenn-Hebert, Catherine, Fléjou, Jean-François, Cubie, Heather, Costagliola, Dominique, Darragh, Teresa M, Franceschi, S, Palefsky, J, Heard, I, Costagliola, D, Cubie, H, Bergeron, C, Carcelain, G, Foulot, H, Crenn-Hébert, C, Tubiana, R, Poizot-Martin, I, Richet, A Isabelle, Lefebvre, B, Jablonski, C Rousset, Viard, JP, Garau, X Sastre, Bonmarchand, M, Cuccu, L, Richet, A, Torchin, D, Carbonne, B, Fléjou, JF, Hoyeau, N, Poizot, I, Ducassou, MJ, Ressiot, E, Figarella-Branger, D, Meier, F, Gorbatchev, C, Rousset-Jablonski, C, Etienney, I, Lesage, A, Potard, V, Taibi, S, Cubie, Virology H, and Moore, C
- Subjects
Cervical Cancer ,Digestive Diseases ,Clinical Research ,Prevention ,Sexually Transmitted Infections ,Infectious Diseases ,Cancer ,Cost Effectiveness Research ,HIV/AIDS ,2.2 Factors relating to the physical environment ,Aetiology ,2.1 Biological and endogenous factors ,Infection ,Good Health and Well Being ,Adult ,Anus Neoplasms ,Asymptomatic Diseases ,Biopsy ,Cohort Studies ,Condylomata Acuminata ,Cross-Sectional Studies ,Cytological Techniques ,Female ,HIV Infections ,Histocytochemistry ,Humans ,Middle Aged ,Papillomaviridae ,Papillomavirus Infections ,Precancerous Conditions ,Prevalence ,Risk Assessment ,ANRS-C017 VIHGY Study Group ,HIV ,anal cancer screening ,anal intraepithelial neoplasia ,human papillomavirus ,women ,Biological Sciences ,Medical and Health Sciences ,Microbiology - Abstract
BackgroundAlthough human immunodeficiency virus (HIV)-infected women are at high risk for anal cancer, few data have been published on prevalence of and risk factors for anal precancer and potential screening strategies in this risk group.MethodsA cross-sectional anal screening study was nested in a gynecological cohort of HIV-infected women. Anal swab specimens were collected for cytology and human papillomavirus (HPV) testing. High-resolution anoscopy, with biopsy when indicated, was systematically performed.ResultsAmong the 171 enrolled women, median age was 47.3 years and 98% were receiving combination antiretroviral therapy. Median CD4(+) count was 655 cells/µL and HIV load was
- Published
- 2015