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Actualmente, toma interés el abordaje de la satisfacción laboral como un aspecto clave en el desarrollo y rendimiento de todo tipo de organizaciones. Una empresa que posee altos niveles de satisfacción entre sus empleados posee mejores niveles de rendimiento. En el caso del sector textil de Arequipa, Perú, la aplicación de estrategias para la satisfacción laboral es un área que se encuentra en construcción. El objetivo de este trabajo es describir la satisfacción laboral de trabajadores de empresas de fabricación textil de Arequipa, Perú. La investigación es cuantitativa, de tipo no experimental y de corte descriptivo, se aplicó un cuestionario a trabajadores de algunas empresas del sector. Los resultados indican que los trabajadores de estas organizaciones se encuentran medianamente satisfechos en sus puestos de trabajo, evidenciando así un déficit en el máximo rendimiento posible por parte de estas empresas. Los directores y gerentes de estas empresas deben generar políticas encaminadas a mejorar los niveles de satisfacción laboral, permitiendo de este modo incrementar la productividad y eficacia de sus organizaciones.

Ubiquitous in most superconducting materials, weak-links are well-known for their limiting effect on the critical current. Still, they are at the root of important features of superconductivity. Using quantitative magneto-optical imaging and the thermomagnetic model, we correlate local maxima in magnetization loops of patterned Nb films to a magnetic field-induced weak-to-strong-link crossover. This tunable phenomenon can be exploited in superconducting electronics, e.g., flux valves and injectors, or as a simple strategy to adjust the critical current in specialized devices., Comment: 7 pages and 4 figures

Anaplastic lymphoma kinase–negative anaplastic large cell lymphoma (ALK– ALCL) is an aggressive neoplasm of T-cell/null-cell lineage. The T-Cell Project is a global prospective cohort study that consecutively enrolled patients newly diagnosed with peripheral T-cell lymphoma, registered through a centralized computer database between September 2006 and February 2018. Of 1553 validated cases from 74 sites in 13 countries worldwide, 235 were reported as ALK– ALCL. The median age at diagnosis was 54 years (range, 18-89 years), with a male predominance (62%). Stage III to IV disease was identified in 71% of patients, bulky disease and bone marrow involvement were uncommon, and 66% of patients presented with a low (0-1) International Prognostic Index score. Of all treated patients, 85% received multiagent initial chemotherapy, and 8% were consolidated with autologous hematopoietic cell transplantation. The initial overall and complete response rates were 77% and 63%, respectively. After a median follow-up of 52 months (95% confidence interval [CI], 41-63), the median progression-free survival (PFS) and overall survival (OS) were 41 months (95% CI, 17-62) and 55 months (95% CI, 36-75), respectively. The 3- and 5-year PFS rates were 52% and 43%, and the 3- and 5-year OS rates were 60% and 49%. Treatments containing both anthracycline and etoposide were associated with superior OS (P = .05) but not PFS (P = .18). In this large prospective cohort study, outcomes comparable to those previously reported in the retrospective International Peripheral T-Cell Lymphoma Project were observed. The study underscores the need for introducing novel platforms for ALK– ALCL and establishes a benchmark for future clinical trials. This trial was registered at www.clinicaltrials.gov as #NCT01142674.

El estudio tuvo como objetivo explicar lo que se entiende por calidad educativa y las consideraciones filosóficas que se deben exponer en un contexto de realidad virtual por la pandemia de la COVID-19. El estudio se apoya en el paradigma histórico hermenéutico, de enfoque cualitativo, socio crítico; para ello, se realizó un rastreo minucioso de información documental. Entre los principales hallazgos, se tiene que, en la situación de pandemia el paradigma más aceptado es el constructivista, en el que la incorporación de las TIC juega un papel importante. Igualmente, en cuanto a las consideraciones filosóficas, quedan claras las dos aristas que componen el protagonismo que han tenido las TIC en la virtualidad, siendo según su ubicación geográfica, temporal y cultural: el ingenieril y humanístico. Finalmente, se concluye que la educación de calidad constituye la principal herramienta para combatir los diversos problemas sociales y lograr niveles óptimos de crecimiento y desarrollo, tanto social como económico; sin embargo, para entenderlo no puede dejarse de lado la filosofía involucrada en el mismo proceso de enseñanza-aprendizaje, en una realidad social o cultural.

En el ámbito internacional se vivencian grandes desafíos y retos, en este escenario, las poblaciones hacen frente a las adversidades y logran salir adelante superándolas, gracias a la resiliencia. La presente investigación tuvo como objetivo determinar las diferencias que existen en los factores asociados a la resiliencia en los docentes de las escuelas públicas de Lima Metropolitana en Perú, según grado académico, sexo y situación laboral. El enfoque de la investigación fue cuantitativo, diseño no experimental, tipo descriptiva, nivel comparativo. El instrumento utilizado fue la Escala de Resiliencia Docente (Guerra, 2013), el cual fue alcanzado a través de formulario google, la muestra estuvo representada por 384 docentes de dichas escuelas públicas. Los hallazgos del estudio evidencian que no existen diferencias significativas en la resiliencia docente según la situación laboral; sin embargo, existen diferencias significativas en la resiliencia docente según el sexo y grado académico. Se concluye, que no existen diferencias significativas en la resiliencia según la percepción de los propios docentes respecto a la situación laboral; sin embargo, se aprecia que existen diferencias significativas en cuanto al sexo y grado académico, lo que está demostrando que estas características son determinantes para diferenciar los niveles de resiliencia que se van alcanzando.

La mujer a lo largo de la historia tuvo un rol importante como madre, esposa e integrante de la sociedad; aunque muchas veces, su presencia y aporte fue invisibilizado. La presente investigación tuvo como objetivo explicar la importancia de la presencia de la mujer a través de la historia de la humanidad; este artículo de revisión se apoya en el paradigma histórico hermenéutico de enfoque cualitativo. El estudio es explicativo, se realizó un rastreo cuidadoso de información documental en las cuales se abordóel rol que ha tenido la mujer en la historia. Se investigóel término en estudio, analizándolo a través del tiempo. Los resultados indican que la importancia que ha tenido la mujer a través de la historia, está en su situación humana y propia de ser mujer, con sus particulares características físicas, psicológicas y emocionales; siendo una integrante de un entorno social, en el que, por las razones culturales, muchas veces, no se respetó sus derechos, recibiendo un trato injusto. Las conclusiones

International audience; We describe the MAPA project, funded under the Connecting Europe Facility programme, whose goal is the development of an open-source de-identification toolkit for all official European Union languages. It will be developed since January 2020 until December 2021.

RESUMEN Objetivo: El objetivo del presente estudio es verificar por primera vez en la literatura el efecto sintomático y modificador de enfermedad del ozono (O2-O3) mediante la mejoría clínica (dolor, función y rigidez), bioquímica (proteína C-reactiva [PCR], velocidad de sedimentación globular [VSG], ácido úrico) y radiológica (mínimo espacio articular medial y lateral) en una serie de pacientes con artrosis de rodilla. Material y métodos: Se realizó un estudio cuasiexperimental prospectivo tipo antes y después a 115 pacientes con artrosis de rodilla con Kellgren-Lawrence grado 2 o más. El protocolo de ozono consistió en 4 sesiones (una sesión/semana) de una infiltración intrarticular de 20 ml de una mezcla médica de oxígeno-ozono (95-5 %) a una concentración de 20 µg/ml. Las variables de resultado incluyeron variables clínicas (dolor, rigidez y función), bioquímicas (PCR, VSG, ácido úrico) y radiológicas (mínimo espacio articular femorotibial). Resultados: La edad media de los pacientes fue de 64.81 ± 11.22 años. Los pacientes femeninos representaron el 75.6 % (n = 87), con una relación mujer/hombre de 3:1. Variables bioquímicas: la PCR disminuyó de 0.42 ± 0.54 mg/dl a 0.31 ± 0.33 mg/dl (p = 0.0142). La VSG disminuyó sus valores desde 14.52 ± 10.14 mm/h hasta 13.08 ± 8.78 mm/h (p = 0,0014). El ácido úrico en suero disminuyó su valor de 5.12 ± 1.22 mg/dl a 5.05 ± 1.24 (p = 0.1307). Variables clínicas: el ozono (O2-O3) mejoró significativamente las variables clínicas dolor, rigidez y función (p = 0.0000). El dolor medido por EVA fue de 7.11 ± 1.11 puntos y disminuyó significativamente a 3.56 ± 1.56 puntos (p = 0.0000). Antes de la intervención, la subescala WOMAC-dolor fue de 14.3 ± 2.29 puntos y disminuyó a 7.13 ± 3.13 puntos (p = 0.0000), la subescala WOMAC-rigidez fue de 2.73 ± 1.39 puntos y disminuyó a 1.16 ± 1.13 puntos (p = 0.0000), la subescala WOMAC-función fue de 41.66 ± 8.1 puntos y mejoró a 25.29 ± 9.72 puntos (p = 0.0000). Variables radiológicas: en 53 pacientes analizados radiológicamente (según protocolo estandarizado) al año de seguimiento después del tratamiento con ozono, el compartimento interno aumento significativamente de 4.12 ± 1.41 mm a 4.4 ± 1.35 mm (p = 0.0008) y el compartimento externo aumentó de 6 ± 1.37 a 6.16 ± 1.4 mm (p = 0.0753). Conclusiones: El ozono intrarticular ha demostrado efecto sintomático y modificador de la enfermedad en los pacientes con artrosis de rodilla, mejorando el dolor, la función y la rigidez; disminuyendo los marcadores de inflamación (PCR, VSG y ácido úrico), y aumentando el mínimo espacio articular del componente medial y lateral evidenciado radiológicamente. En este estudio se ha evidenciado que el ozono modula la inflamación, disminuye el dolor y la rigidez, mejora la función y tiene efecto anabólico en los pacientes con artrosis de rodilla. No se ha observado ningún efecto adverso tras las infiltraciones intrarticulares de ozono. ABSTRACT Purpose: The objective of the present study is to verify for the first time in the literature the symptomatic and modifying disease effect of ozone (O2-O3) through clinical (pain, function and stiffness), biochemical (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR], uric acid) and radiological improvement (minimum medial and lateral joint space) in a series of patients with osteoarthritis of the knee. Methods: A prospective quasi-experimental before-and-after study was performed in 115 patients with knee osteoarthritis Kellgren-Lawrence grade 2 or more. The ozone protocol consisted of 4 sessions (one session / week) of an intra-articular injection of 20 ml of a medical mixture of Oxygen-Ozone (95-5ºC) at a concentration of 20 µg / ml. Outcome variables included clinical (pain, stiffness, and function), biochemical (CRP, ESR, uric acid), and radiological variables (minimal femorotibial joint space). Results: Mean age of the patients was 64.81 ± 11.22 years. Female patients accounted for 75.6 % (n = 87), with a female / male ratio of 3 : 1. Biochemical-variables: CRP decreased from 0.42 ± 0.54 mg/dL to 0.31 ± 0.33 mg/dL (p = 0.0142). ESR decreased from 14.52 ± 10.14 mm/h to 13.08 ± 8.78 mm/h (p= 0.0014). Serum uric acid decreased from 5.12 ± 1.22 mg/dL to 5.05 ± 1.24 (p = 0.1307). Clinical variables: Ozone (O2-O3) significantly improved pain, stiffness and function clinical variables (p = 0.0000). Pain measured by VAS was 7.11 ± 1.11 points and decreased significantly to 3.56 ± 1.56 points (p = 0.0000). Before the intervention, WOMAC-pain subscale was 14.3 ± 22.29 points and decreased to 7.13 ± 33.13 points (p = 0.0000), WOMAC-stiffness subscale was 2.73 ± 1.39 points and decreased to 1.16 ± 1.13 points (p = 0.0000), WOMAC-function subscale was 41.66 ± 8, 1 points and improved to 25.29 ± 9.72 points (p = 0.0000). Radiological variables: In 53 patients analyzed radiologically (according to standardized protocol) at one year of follow-up after ozone treatment, the internal compartment increased significantly from 4.12 ± 1.41 mm to 4.4 ± 1.35 mm (p = 0.0008) and the external compartment increased from 6 ± 1.37 to 6.16 ± 1.4 mm (p = 0.0753). Conclusions: Intra articular ozone has demonstrated a symptomatic and disease modifying effect in patients with osteoarthritis of the knee, improving pain, function and stiffness; decreasing markers of inflammation (CRP, ESR and uric acid), and increasing the minimal joint space of the medial and lateral component evidenced radiologically. In this study it has been shown that ozone modulates inflammation, decreases pain and stiffness, improves function and has an anabolic effect in patients with osteoarthritis of the knee. No adverse effect has been observed after intra articular infiltrations of ozone.

Pediatric acute B-cell lymphoblastic leukemia (B-ALL) constitutes a heterogeneous and aggressive neoplasia in which new targeted therapies are required. Long non-coding RNAs have recently emerged as promising disease-specific biomarkers for the clinic. Here, we identified pediatric B-ALL-specific lncRNAs and associated mRNAs by comparing the transcriptomic signatures of tumoral and non-tumoral samples. We identified 48 lncRNAs that were differentially expressed between pediatric B-ALL and healthy bone marrow samples. The most relevant lncRNA/mRNA pair was AL133346.1/CCN2 (previously known as RP11-69I8.3/CTGF), whose expression was positively correlated and increased in B-ALL samples. Their differential expression pattern and their strong correlation were validated in external B-ALL datasets (Therapeutically Applicable Research to Generate Effective Treatments, Cancer Cell Line Encyclopedia). Survival curve analysis demonstrated that patients with "high" expression levels of CCN2 had higher overall survival than those with "low" levels (p = 0.042), and this gene might be an independent prognostic biomarker in pediatric B-ALL. These findings provide one of the first detailed descriptions of lncRNA expression profiles in pediatric B-ALL and indicate that these potential biomarkers could help in the classification of leukemia subtypes and that CCN2 expression could predict the survival outcome of pediatric B-cell acute lymphoblastic leukemia patients.

Mammalian SWI/SNF (SWitch/Sucrose Non-Fermentable) complexes are ATP-dependent chromatin remodelers whose subunits have emerged among the most frequently mutated genes in cancer. Studying SWI/SNF function in cancer cell line models has unveiled vulnerabilities in SWI/SNF-mutant tumors that can lead to the discovery of new therapeutic drugs. However, choosing an appropriate cancer cell line model for SWI/SNF functional studies can be challenging because SWI/SNF subunits are frequently altered in cancer by various mechanisms, including genetic alterations and post-transcriptional mechanisms. In this work, we combined genomic, transcriptomic, and proteomic approaches to study the mutational status and the expression levels of the SWI/SNF subunits in a panel of 38 lung adenocarcinoma (LUAD) cell lines. We found that the SWI/SNF complex was mutated in more than 76% of our LUAD cell lines and there was a high variability in the expression of the different SWI/SNF subunits. These results underline the importance of the SWI/SNF complex as a tumor suppressor in LUAD and the difficulties in defining altered and unaltered cell models for the SWI/SNF complex. These findings will assist researchers in choosing the most suitable cellular models for their studies of SWI/SNF to bring all of its potential to the development of novel therapeutic applications.

This study aims to implement the predictive multivariable DMC controller in a real plant and compare it to multi-loop PID. The practical application is made in a pilot plant located in the IFES / Serra, where pressure and level are controlled with pump speed and valve opening. Tuning of the DMC controller is obtained through a simulator based on genetic algorithm. The plant responses to step using multi-loop PID and DMC are compared with and without constraints on valve opening and pump speed. The DMC controller is also tested with output restriction (pressure and level). The didactic interface developed with LabVIEW software is used to interact with MATLAB and CompactRIO controller, allowing the use of MATLAB optimization functions in the implementation of the DMC controller.

Comunicació presentada a la Tenth International Conference on Language Resources and Evaluation (LREC 2016), celebrada els dies 23 a 28 de maig de 2016 a Portorož, Eslovènia. A key point in Sentiment Analysis is to determine the polarity of the sentiment implied by a certain word or expression. In basic Sentiment Analysis systems this sentiment polarity of the words is accounted and weighted in different ways to provide a degree of positivity/negativity. Currently words are also modelled as continuous dense vectors, known as word embeddings, which seem to encode interesting semantic knowledge. With regard to Sentiment Analysis, word embeddings are used as features to more complex supervised classification systems to obtain sentiment classifiers. In this paper we compare a set of existing sentiment lexicons and sentiment lexicon generation techniques. We also show a simple but effective technique to calculate a word polarity value for each word in a domain using existing continuous word embeddings generation methods. Further, we also show that word embeddings calculated on in-domain corpus capture the polarity better than the ones calculated on general-domain corpus. This work has been supported by Vicomtech-IK4 and partially funded by TUNER project (TIN2015-65308-C5-1-R).

Background: The International Peripheral T-cell Lymphoma Project was organized to better understand the T-cell and natural killer (NK) cell lymphomas, and our task is to present the clinicopathologic correlations and therapeutic results for adult T-cell leukemia/lymphoma (ATL). Patients and methods: Among 1153 patients with T-cell or NK cell lymphomas, 126 patients (9.6%) with ATL were represented in this project. All were categorized as aggressive ATL, i.e. acute or lymphoma type, and 87% fell into the lymphoma type. Results: The median age was 62 years and the male to female ratio was 1.2 : 1. Significant prognostic factors for overall survival (OS) by univariate analysis were the presence of B symptoms (P = 0.018), platelet count

Purpose Peripheral T-cell lymphoma (PTCL) and natural killer/T-cell lymphoma (NKTCL) are rare and heterogeneous forms of non-Hodgkin's lymphoma (NHL) that, in general, are associated with a poor clinical outcome. Patients and Methods A cohort of 1,314 cases of PTCL and NKTCL was organized from 22 centers worldwide, consisting of patients with previously untreated PTCL or NKTCL who were diagnosed between 1990 and 2002. Tissue biopsies, immunophenotypic markers, molecular genetic studies, and clinical information from consecutive patients at each site were reviewed by panels of four expert hematopathologists and classified according to the WHO classification. Results A diagnosis of PTCL or NKTCL was confirmed in 1,153 (87.8%) of the cases. The most common subtypes were PTCL not otherwise specified (NOS; 25.9%), angioimmunoblastic type (18.5%), NKTCL (10.4%), and adult T-cell leukemia/lymphoma (ATLL; 9.6%). Misclassification occurred in 10.4% of the cases including Hodgkin's lymphoma (3%), B-cell lymphoma (1.4%), unclassifiable lymphoma (2.8%), or a diagnosis other than lymphoma (2.3%). We found marked variation in the frequency of the various subtypes by geographic region. The use of an anthracycline-containing regimen was not associated with an improved outcome in PTCL-NOS or angioimmunoblastic type, but was associated with an improved outcome in anaplastic large-cell lymphoma, ALK positive. Conclusion The WHO classification is useful for defining subtypes of PTCL and NKTCL. However, expert hematopathology review is important for accurate diagnosis. The clinical outcome for patients with most of these lymphoma subtypes is poor with standard therapies, and novel agents and new modalities are needed to improve survival.