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735 results on '"Csiba, László"'

1. Prevention of infections and fever to improve outcome in older patients with acute stroke (PRECIOUS): a randomised, open, phase III, multifactorial, clinical trial with blinded outcome assessment

Author

Kerkhoff, Henk, Wermer, Marieke JH., Jellema, Korné, Kwa, Vincent IH., Jansen, Ben P., Schreuder, Tobien AHCML., Zinkstok, Sanne M., Moudrous, Walid, Antsov, Katrin, Gross-Paju, Katrin, Kalju, Inga, Hamann, Gerhard F., Rosenkranz, Michael, Gumbinger, Christoph, Royl, Georg, Müller, Susanne, Vassilopoulou, Sophie, Protogerou, Athanasios D., Manios, Efstathios, Bereczki, Dániel, Jakab, Gábor, Nagy, Ferenc, Folyovich, András, Szapáry, László, Gilberti, Nicola, Righetti, Enrico, Bassi, Pietro, Marcheselli, Simona, Giossi, Alessia, Holtan, Anne G., Maini, Sameer, Fryze, Waldemar, Brola, Waldemar, Sobolewski, Piotr, Bilik, Marta, Davies, Ruth, Nair, Anand, Dutta, Dipankar, Cooper, Martin, Rashed, Khalid, Shaw, Louise, Selvarajah, Johann R., Redgrave, Jessica, MacLeod, Mary Joan, Clatworthy, Philip, Papavasileiou, Vasileios, Cvoro, Vera, Halse, Omid, Ghani, Usman, de Jonge, Jeroen C., Sluis, Wouter M., Reinink, Hendrik, Bath, Philip M., Woodhouse, Lisa J., Zweedijk, Berber, van de Beek, Diederik, Aamodt, Anne Hege, Alpers, Iris, Ciccone, Alfonso, Csiba, Laszlo, Demotes, Jacques, Kõrv, Janika, Kurkowska-Jastrzebska, Iwona, Dawson, Jesse, Macleod, Malcolm R., Ntaios, George, Poli, Sven, Milionis, Haralampos, Ricci, Stefano, Cenciarelli, Silvia, Candelaresi, Paolo, de Bruijn, Sebastiaan FTM., Pathansali, Rohan, Krishnan, Kailash, Clarke, Brian, Thomalla, Götz, and van der Worp, H Bart

Published
2024
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2. Carotid Disease: Usefulness of the Ultrasound

Author

Pánczél, Gyula, Kemény, Vendel, Oláh, László, Csiba, László, Rodríguez, Camilo N., editor, Baracchini, Claudio, editor, Mejia-Mantilla, Jorge H., editor, Czosnyka, Marek, editor, Suarez, Jose I, editor, Csiba, László, editor, Puppo, Corina, editor, and Bartels, Eva, editor

Published
2022
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3. Assessment of malformations, variations and diameters of vessels forming the circle of Willis – An autopsy study in a non-cerebrovascular cohort

Author

Orosz László, Gyöngyösi Zoltán, Susán Zsolt, Siró Péter, Hoksbergen Arjan Willem, Csiba László, and Fülesdi Béla

Subjects
circle of willis, autopsy, diameter, configuration, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

The collateral capacity of the circle of Willis (CoW) may play an important role in the development of ischemic strokes. The occurrence of classical polygon shows wide geographical variations and morphological data on diameters of the Willisian collaterals are scarce. We aimed to assess CoW variations and vessel diameters in a Central European cohort.

Published
2022
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4. Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial

Author

Shoamanesh, Ashkan, Mundl, Hardi, Smith, Eric E, Masjuan, Jaime, Milanov, Ivan, Hirano, Teruyuki, Agafina, Alina, Campbell, Bruce, Caso, Valeria, Mas, Jean-Louis, Dong, Qiang, Turcani, Peter, Christensen, Hanne, Ferro, Jose M, Veltkamp, Roland, Mikulik, Robert, De Marchis, Gian Marco, Robinson, Thompson, Lemmens, Robin, Stepien, Adam, Greisenegger, Stefan, Roine, Risto, Csiba, Laszlo, Khatri, Pooja, Coutinho, Jonathan, Lindgren, Arne G, Demchuk, Andrew M, Colorado, Pablo, Kirsch, Bodo, Neumann, Christoph, Heenan, Laura, Xu, Lizhen, Connolly, Stuart J, and Hart, Robert G

Published
2022
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5. Evidence for postnatal neurogenesis in the human amygdala

Author

Roeder, Sebastian S., Burkardt, Petra, Rost, Fabian, Rode, Julian, Brusch, Lutz, Coras, Roland, Englund, Elisabet, Håkansson, Karl, Possnert, Göran, Salehpour, Mehran, Primetzhofer, Daniel, Csiba, László, Molnár, Sarolta, Méhes, Gábor, Tonchev, Anton B., Schwab, Stefan, Bergmann, Olaf, and Huttner, Hagen B.

Published
2022
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9. Neuropsychiatric symptoms, quality of life and caregivers’ burden in dementia

Author

Majer Réka, Adeyi Olar, Bagoly Zsuzsa, Simon Viktória, Csiba László, Kardos László, Hortobágyi Tibor, and Frecska Ede

Subjects
caregivers, caregivers’ burden, dementia, illness intrusiveness, neurocognitive disorders, neuropsychiatric symptoms of dementia, quality of life, Medicine
Abstract

The objective of this research is to identify the relationship between the neuropsychiatric symptoms (NPSs) of patients with major neurocognitive disorder (mNCD), their quality of life, illness intrusiveness and the caregiver’s burden. We assessed 131 patients with mNCD. Examination methods included WHO well-being index short version, illness intrusiveness rating scale, Alzheimer’s Disease Assessment Scale-Cog, Mini Mental State Examination and neuropsychiatric inventory. The results were analysed using standard statistical tests. In our sample, the prevalence of NPSs is 100%. A significant correlation (p < 0.0001) was observed with quality of life and illness intrusiveness. Additionally, a strong relationship was observed between NPSs and the caregiver’s burden (r = 0.9). The result is significantly twice as much stronger in comparison to the relationship between NPS and cognitive symptoms (r = 0.4). This is the first study in Hungary to assess the impact of NPS on the burden of relatives and quality of life. NPS had twice stronger impact on caregivers’ burden than cognitive decline. However, further studies are needed to assess the sub-syndromes in mNCD in relation to NPS.

Published
2020
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10. Correlation between calcium, water contents and ultrasonographic appearance of atherosclerotic lesions of carotid artery lesions

Author

Fülesdi Béla, Farkas Szabolcs, Gyöngyösi Zoltán, Siró Péter, Bereczki Dániel, Bacsó József, and Csiba László

Subjects
ca and water contents, carotid plaque, b-mode ultrasound, ultrasonic tissue characterisation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

We tested the hypothesis whether there is a correlation between the echogenicity and calcium and water contents of carotid plaques.

Published
2020
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16. Behavioural and psychological symptoms in neurocognitive disorders: Specific patterns in dementia subtypes

Author

Majer Réka, Simon Viktória, Csiba László, Kardos László, Frecska Ede, and Hortobágyi Tibor

Subjects
alzheimer’s disease, behaviour and psychological symptoms in dementia (bpsd), dementia, neurocognitive disorder, vascular dementia, Medicine
Abstract

Behavioural and psychological symptoms in dementia (BPSD) form an important sub-syndrome of dementia. We assessed the frequency and severity of BPSD in a random sample of Hungarian treatment-naïve dementia patients. Furthermore, we examined the relationship between cognitive symptoms and BPSD and the pattern of BPSD in specific types of dementias.

Published
2019
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17. Prestroke CHA2DS2-VASc Score and Severity of Acute Stroke in Patients with Atrial Fibrillation: Findings from RAF Study

Author

Acciarresi, Monica, Paciaroni, Maurizio, Agnelli, Giancarlo, Falocci, Nicola, Caso, Valeria, Becattini, Cecilia, Marcheselli, Simona, Rueckert, Christina, Pezzini, Alessandro, Morotti, Andrea, Costa, Paolo, Padovani, Alessandro, Csiba, Laszló, Szabó, Lilla, Sohn, Sung-Il, Tassinari, Tiziana, Abdul-Rahim, Azmil H., Michel, Patrik, Cordier, Maria, Vanacker, Peter, Remillard, Suzette, Alberti, Andrea, Venti, Michele, D'Amore, Cataldo, Scoditti, Umberto, Denti, Licia, Orlandi, Giovanni, Chiti, Alberto, Gialdini, Gino, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Putaala, Jukka, Tatlisumak, Turgut, Masotti, Luca, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Martini, Giuseppe, Tsivgoulis, Georgios, Vadikolias, Kostantinos, Liantinioti, Chrissoula, Corea, Francesco, Del Sette, Massimo, Ageno, Walter, De Lodovici, Maria Luisa, Bono, Giorgio, Baldi, Antonio, D'Anna, Sebastiano, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Consoli, Domenico, Galati, Franco, Pieroni, Alessio, Toni, Danilo, Monaco, Serena, Baronello, Mario Maimone, Barlinn, Kristian, Pallesen, Lars-Peder, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, Mosconi, Maria Giulia, and Lees, Kennedy R.

Published
2017
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23. Enalapril Is Superior to Lisinopril in Improving Endothelial Function without a Difference in Blood–Pressure–Lowering Effects in Newly Diagnosed Hypertensives.

Author

Nagy, Attila, Májer, Réka, Boczán, Judit, Sipka Jr., Sándor, Szabó, Attila, Enyedi, Enikő Edit, Tatai, Ottó, Fagyas, Miklós, Papp, Zoltán, Csiba, László, and Tóth, Attila

Subjects
LISINOPRIL, AMBULATORY blood pressure monitoring, ENALAPRIL, SYSTOLIC blood pressure, CAROTID intima-media thickness, ENDOTHELIUM diseases
Abstract

Angiotensin–converting enzyme (ACE) inhibitors are the primarily chosen drugs to treat various cardiovascular diseases, such as hypertension. Although the most recent guidelines do not differentiate among the various ACE inhibitory drugs, there are substantial pharmacological differences. Goal: Here, we tested if lipophilicity affects the efficacy of ACE inhibitory drugs when used as the first therapy in newly identified hypertensives in a prospective study. Methods: We tested the differences in the cardiovascular efficacy of the hydrophilic lisinopril (8.3 ± 3.0 mg/day) and the lipophilic enalapril (5.5 ± 2.3 mg/day) (n = 59 patients). The cardiovascular parameters were determined using sonography (flow-mediated dilation (FMD) in the brachial artery, intima-media thickness of the carotid artery), 24 h ambulatory blood pressure monitoring (peripheral arterial blood pressure), and arteriography (aortic blood pressure, augmentation index, and pulse wave velocity) before and after the initiation of ACE inhibitor therapy. Results: Both enalapril and lisinopril decreased blood pressure. However, lisinopril failed to improve arterial endothelial function (lack of effects on FMD) when compared to enalapril. Enalapril-mediated improved arterial endothelial function (FMD) positively correlated with its blood–pressure–lowering effect. In contrast, there was no correlation between the decrease in systolic blood pressure and FMD in the case of lisinopril treatment. Conclusion: The blood–pressure–lowering effects of ACE inhibitor drugs are independent of their lipophilicity. In contrast, the effects of ACE inhibition on arterial endothelial function are associated with lipophilicity: the hydrophilic lisinopril was unable to improve, while the lipophilic enalapril significantly improved endothelial function. Moreover, the effects on blood pressure and endothelial function did not correlate in lisinopril-treated patients, suggesting divergent mechanisms in the regulation of blood pressure and endothelial function upon ACE inhibitory treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Elevated Blood Alcohol Concentration Is Associated with Improved Clinical Outcomes of Intravenous Thrombolysis Treatment in Acute Ischemic Stroke Patients—A Retrospective Study

Author

Árokszállási, Tamás, primary, Balogh, Eszter, additional, Orbán-Kálmándi, Rita, additional, Pásztor, Máté, additional, Árokszállási, Anita, additional, Nagy, Edit Boglárka, additional, Belán, Ivett, additional, May, Zsolt, additional, Csépány, Tünde, additional, Csiba, László, additional, Bagoly, Zsuzsa, additional, and Oláh, László, additional

Published
2023
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38. Intra-Arterial Thrombolysis in Second Trimester of Pregnancy. A Case Report

Author

Pongrácz Endre, Farkas Szabolcs, and Csiba László

Subjects
ischemic stroke, pregnancy, intra-arterial thrombolysis, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Here we present a successful intra-arterial thrombolysis performed in the second trimester of pregnancy (21 weeks). The intervention resulted in complete recanalization of the occluded right middle cerebral artery and favourable clinical and gestational outcome. Together with cases described in respective medical literature our report affirms that in pregnancy acute ischemic stroke could be treated effectively applying intra-arterial thrombolysis (using rt-PA). This therapy could provide opportunity to help in such desperate situations.

Published
2015
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40. The neuropeptide landscape of human prefrontal cortex

Author

Zhong, Wen, primary, Barde, Swapnali, additional, Mitsios, Nicholas, additional, Adori, Csaba, additional, Oksvold, Per, additional, Feilitzen, Kalle von, additional, O’Leary, Liam, additional, Csiba, László, additional, Hortobágyi, Tibor, additional, Szocsics, Péter, additional, Mechawar, Naguib, additional, Maglóczky, Zsófia, additional, Renner, Éva, additional, Palkovits, Miklós, additional, Uhlén, Mathias, additional, Mulder, Jan, additional, and Hökfelt, Tomas, additional

Published
2022
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44. Effects of acute alcohol consumption on neuronal activity and cerebral vasomotor response

Author

Balogh, Eszter, Árokszállási, Tamás, Körtefái, Katalin, Nagy, Veronika Éva, Csiba, László, and Oláh, László

Subjects
Adult, genetic structures, Alcohol Drinking, Ultrasonography, Doppler, Transcranial, Cerebral vasoreactivity, Transcranial Doppler, Visual activation, Cerebrovascular Circulation, Acute alcohol consumption, Evoked Potentials, Visual, Humans, Original Article, Neurovascular coupling, Blood Flow Velocity
Abstract

Introduction In the majority of European countries, driving after drinking small-moderate amount of alcohol is legal. Motivated by our previous studies on cerebral hemodynamics, we aimed to study whether a small-moderate blood alcohol content (BAC), at which driving is legal in some countries (0.8 g/L), influences the neuronal activity, neurovascular coupling, and cerebral vasoreactivity. Methods Analyses of pattern-reversal visual evoked potential (VEP) and transcranial Doppler (TCD) examinations were performed in thirty young healthy adults before and 30 min after alcohol consumption. Cerebral vasoreactivity was evaluated by breath holding test in both middle cerebral arteries. By using a visual cortex stimulation paradigm, visually evoked flow velocity response during reading was measured in both posterior cerebral arteries (PCA). Results The BAC was 0.82 g/L and 0.94 g/L 30 and 60 min after drinking alcohol, respectively. Latency of the VEP P100 wave increased after alcohol consumption. Resting absolute flow velocity values increased, whereas pulsatility indices in the PCA decreased after alcohol ingestion, indicating vasodilation of cerebral microvessels. Breath holding index and the visually evoked maximum relative flow velocity increase in the PCA and steepness of rise of the flow velocity curve were smaller after than before alcohol consumption. Conclusion BAC close to a legal value at which driving is allowed in some European countries inhibited the neuronal activity and resulted in dilation of cerebral arterioles. Cerebral vasodilation may explain the decrease of cerebral vasoreactivity and might contribute to the disturbance of visually evoked flow response after alcohol consumption.

Published
2021

45. High Neutrophil–Lymphocyte Ratio and Low Lymphocyte–Monocyte Ratio Combination after Thrombolysis Is a Potential Predictor of Poor Functional Outcome of Acute Ischemic Stroke

Author

Sadeghi, Farzaneh, primary, Sarkady, Ferenc, additional, Zsóri, Katalin S., additional, Szegedi, István, additional, Orbán-Kálmándi, Rita, additional, Székely, Edina G., additional, Vasas, Nikolett, additional, Berényi, Ervin, additional, Csiba, László, additional, Bagoly, Zsuzsa, additional, and Shemirani, Amir H., additional

Published
2022
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46. Low α2-Plasmin Inhibitor Antigen Levels on Admission Are Associated With More Severe Stroke and Unfavorable Outcomes in Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis

Author

Székely, Edina Gabriella, primary, Orbán-Kálmándi, Rita, additional, Szegedi, István, additional, Katona, Éva, additional, Baráth, Barbara, additional, Czuriga-Kovács, Katalin Réka, additional, Lóczi, Linda, additional, Vasas, Nikolett, additional, Fekete, István, additional, Fekete, Klára, additional, Berényi, Ervin, additional, Oláh, László, additional, Csiba, László, additional, and Bagoly, Zsuzsa, additional

Published
2022
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47. The neuropeptide landscape of human prefrontal cortex

Author

Zhong, Wen, Barde, Swapnali, Mitsios, Nicholas, Adori, Csaba, Oksvold, Per, Feilitzen, Kalle von, O’Leary, Liam, Csiba, László, Hortobágyi, Tibor, Szocsics, Péter, Mechawar, Naguib, Maglóczky, Zsófia, Renner, Éva, Palkovits, Miklós, Uhlén, Mathias, Mulder, Jan, Hökfelt, Tomas, Zhong, Wen, Barde, Swapnali, Mitsios, Nicholas, Adori, Csaba, Oksvold, Per, Feilitzen, Kalle von, O’Leary, Liam, Csiba, László, Hortobágyi, Tibor, Szocsics, Péter, Mechawar, Naguib, Maglóczky, Zsófia, Renner, Éva, Palkovits, Miklós, Uhlén, Mathias, Mulder, Jan, and Hökfelt, Tomas

Abstract

Human prefrontal cortex (hPFC) is a complex brain region involved in cognitive and emotional processes and several psychiatric disorders. Here, we present an overview of the distribution of the peptidergic systems in 17 subregions of hPFC and three reference cortices obtained by microdissection and based on RNA sequencing and RNAscope methods integrated with published single-cell transcriptomics data. We detected expression of 60 neuropeptides and 60 neuropeptide receptors in at least one of the hPFC subregions. The results reveal that the peptidergic landscape in PFC consists of closely located and functionally different subregions with unique peptide/transmitter-related profiles. Neuropeptide-rich PFC subregions were identified, encompassing regions from anterior cingulate cortex/orbitofrontal gyrus. Furthermore, marked differences in gene expression exist between different PFC regions (>5-fold; cocaine and amphetamine-regulated transcript peptide) as well as between PFC regions and reference regions, for example, for somatostatin and several receptors. We suggest that the present approach allows definition of, still hypothetical, microcircuits exemplified by glutamatergic neurons expressing a peptide cotransmitter either as an agonist (hypocretin/orexin) or antagonist (galanin). Specific neuropeptide receptors have been identified as possible targets for neuronal afferents and, interestingly, peripheral blood-borne peptide hormones (leptin, adiponectin, gastric inhibitory peptide, glucagon-like peptides, and peptide YY). Together with other recent publications, our results support the view that neuropeptide systems may play an important role in hPFC and underpin the concept that neuropeptide signaling helps stabilize circuit connectivity and fine-tune/modulate PFC functions executed during health and disease., Funding agency: National Genomics Infrastructure in Stockholm - Science for Life Laboratory; Knut and Alice Wallenberg Foundation; Swedish Research Council [2018-02753, 2020-02956]; SciLifeLab; Wallenberg Data Driven Life Science Program [KAW 2020.0239]; Hungarian Brain Research Program [2017-1.2.1-NKP-201700002]

Published
2022
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48. The neuropeptide landscape of human prefrontal cortex

Author

Zhong, Wen; https://orcid.org/0000-0002-7422-6104, Barde, Swapnali, Mitsios, Nicholas, Adori, Csaba, Oksvold, Per, von Feilitzen, Kalle, O’Leary, Liam, Csiba, László, Hortobágyi, Tibor; https://orcid.org/0000-0001-5732-7942, Szocsics, Péter, Mechawar, Naguib, Maglóczky, Zsófia, Renner, Éva, Palkovits, Miklós; https://orcid.org/0000-0003-0578-0387, Uhlén, Mathias; https://orcid.org/0000-0002-4858-8056, Mulder, Jan, Hökfelt, Tomas; https://orcid.org/0000-0002-3587-0116, Zhong, Wen; https://orcid.org/0000-0002-7422-6104, Barde, Swapnali, Mitsios, Nicholas, Adori, Csaba, Oksvold, Per, von Feilitzen, Kalle, O’Leary, Liam, Csiba, László, Hortobágyi, Tibor; https://orcid.org/0000-0001-5732-7942, Szocsics, Péter, Mechawar, Naguib, Maglóczky, Zsófia, Renner, Éva, Palkovits, Miklós; https://orcid.org/0000-0003-0578-0387, Uhlén, Mathias; https://orcid.org/0000-0002-4858-8056, Mulder, Jan, and Hökfelt, Tomas; https://orcid.org/0000-0002-3587-0116

Abstract

Human prefrontal cortex (hPFC) is a complex brain region involved in cognitive and emotional processes and several psychiatric disorders. Here, we present an overview of the distribution of the peptidergic systems in 17 subregions of hPFC and three reference cortices obtained by microdissection and based on RNA sequencing and RNAscope methods integrated with published single-cell transcriptomics data. We detected expression of 60 neuropeptides and 60 neuropeptide receptors in at least one of the hPFC subregions. The results reveal that the peptidergic landscape in PFC consists of closely located and functionally different subregions with unique peptide/transmitter–related profiles. Neuropeptide-rich PFC subregions were identified, encompassing regions from anterior cingulate cortex/orbitofrontal gyrus. Furthermore, marked differences in gene expression exist between different PFC regions (>5-fold; cocaine and amphetamine–regulated transcript peptide) as well as between PFC regions and reference regions, for example, for somatostatin and several receptors. We suggest that the present approach allows definition of, still hypothetical, microcircuits exemplified by glutamatergic neurons expressing a peptide cotransmitter either as an agonist (hypocretin/orexin) or antagonist (galanin). Specific neuropeptide receptors have been identified as possible targets for neuronal afferents and, interestingly, peripheral blood-borne peptide hormones (leptin, adiponectin, gastric inhibitory peptide, glucagon-like peptides, and peptide YY). Together with other recent publications, our results support the view that neuropeptide systems may play an important role in hPFC and underpin the concept that neuropeptide signaling helps stabilize circuit connectivity and fine-tune/modulate PFC functions executed during health and disease.

Published
2022

49. Can carotid ultrasound predict neurological risk after carotid intervention?

Author

Yi-chun CHEN, OLÁH, László, and CSIBA, László

Subjects
CAROTID artery ultrasonography, CAROTID artery stenosis, CAROTID endarterectomy, CAROTID artery, ISCHEMIC stroke, ATHEROSCLEROTIC plaque
Abstract

Copyright of Clinical Neuroscience / Ideggyógyászati Szemle is the property of LifeTime Media Kft. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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