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696 results on '"Cserni, Gábor"'

1. TRPS1 expression in breast angiosarcoma

Author

Pancsa, Tamás, Pósfai, Boglárka, Schubert, Anna, Almási, Szintia, Papp, Eszter, Chien, Yi-Che Chang, Kálmán, Endre, Kovács, Kristóf Attila, Kulka, Janina, Varga, Linda, Cserni, Gábor, and Kuthi, Levente

Published
2024
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2. Role of the kisspeptin-KISS1R axis in the pathogenesis of chronic kidney disease and uremic cardiomyopathy

Author

Dinh, Hoa, Kovács, Zsuzsanna Z. A., Kis, Merse, Kupecz, Klaudia, Sejben, Anita, Szűcs, Gergő, Márványkövi, Fanni, Siska, Andrea, Freiwan, Marah, Pósa, Szonja Polett, Galla, Zsolt, Ibos, Katalin Eszter, Bodnár, Éva, Lauber, Gülsüm Yilmaz, Goncalves, Ana Isabel Antunes, Acar, Eylem, Kriston, András, Kovács, Ferenc, Horváth, Péter, Bozsó, Zsolt, Tóth, Gábor, Földesi, Imre, Monostori, Péter, Cserni, Gábor, Podesser, Bruno K., Lehoczki, Andrea, Pokreisz, Peter, Kiss, Attila, Dux, László, Csabafi, Krisztina, and Sárközy, Márta

Published
2024
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5. The kisspeptin-1 receptor antagonist peptide-234 aggravates uremic cardiomyopathy in a rat model

Author

Dinh, Hoa, Kovács, Zsuzsanna Z. A., Márványkövi, Fanni, Kis, Merse, Kupecz, Klaudia, Szűcs, Gergő, Freiwan, Marah, Lauber, Gülsüm Yilmaz, Acar, Eylem, Siska, Andrea, Ibos, Katalin Eszter, Bodnár, Éva, Kriston, András, Kovács, Ferenc, Horváth, Péter, Földesi, Imre, Cserni, Gábor, Podesser, Bruno K., Pokreisz, Peter, Kiss, Attila, Dux, László, Csabafi, Krisztina, and Sárközy, Márta

Published
2023
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7. Neuregulin-1β Improves Uremic Cardiomyopathy and Renal Dysfunction in Rats

Author

Sárközy, Márta, Watzinger, Simon, Kovács, Zsuzsanna Z.A., Acar, Eylem, Márványkövi, Fanni, Szűcs, Gergő, Lauber, Gülsüm Yilmaz, Galla, Zsolt, Siska, Andrea, Földesi, Imre, Fintha, Attila, Kriston, András, Kovács, Ferenc, Horváth, Péter, Kővári, Bence, Cserni, Gábor, Krenács, Tibor, Szabó, Petra Lujza, Szabó, Gábor Tamás, Monostori, Péter, Zins, Karin, Abraham, Dietmar, Csont, Tamás, Pokreisz, Peter, Podesser, Bruno K., and Kiss, Attila

Published
2023
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8. Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer

Author

De Schepper, Maxim, Vincent-Salomon, Anne, Christgen, Matthias, Van Baelen, Karen, Richard, François, Tsuda, Hitoshi, Kurozumi, Sasagu, Brito, Maria Jose, Cserni, Gabor, Schnitt, Stuart, Larsimont, Denis, Kulka, Janina, Fernandez, Pedro Luis, Rodríguez-Martínez, Paula, Olivar, Ana Aula, Melendez, Cristina, Van Bockstal, Mieke, Kovacs, Aniko, Varga, Zsuzsanna, Wesseling, Jelle, Bhargava, Rohit, Boström, Pia, Franchet, Camille, Zambuko, Blessing, Matute, Gustavo, Mueller, Sophie, Berghian, Anca, Rakha, Emad, van Diest, Paul J., Oesterreich, Steffi, Derksen, Patrick W.B., Floris, Giuseppe, and Desmedt, Christine

Published
2022
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9. High expression of progesterone receptor may be an adverse prognostic factor in oestrogen receptor-negative/progesterone receptor-positive breast cancer: results of comprehensive re-evaluation of multi-institutional case series

Author

Kunc, Michał, Pęksa, Rafał, Cserni, Gabor, Iżycka-Świeszewska, Ewa, Łacko, Aleksandra, Radecka, Barbara, Braun, Marcin, Pikiel, Joanna, Litwiniuk, Maria, Pogoda, Katarzyna, Szwajkosz, Anna, Biernat, Wojciech, and Senkus, Elżbieta

Published
2022
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10. Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome

Author

Tóth, Melinda E., Sárközy, Márta, Szűcs, Gergő, Dukay, Brigitta, Hajdu, Petra, Zvara, Ágnes, Puskás, László G., Szebeni, Gábor J., Ruppert, Zsófia, Csonka, Csaba, Kovács, Ferenc, Kriston, András, Horváth, Péter, Kővári, Bence, Cserni, Gábor, Csont, Tamás, and Sántha, Miklós

Published
2022
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13. Sentinel Node

Author

Cserni, Gábor, van Krieken, J. H. J. M., Series Editor, Sapino, Anna, editor, and Kulka, Janina, editor

Published
2020
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14. Digital Whole Slide Image Analysis of Elevated Stromal Content and Extracellular Matrix Protein Expression Predicts Adverse Prognosis in Triple-Negative Breast Cancer.

Author

Karancsi, Zsófia, Gregus, Barbara, Krenács, Tibor, Cserni, Gábor, Nagy, Ágnes, Szőcs-Trinfa, Klementina Fruzsina, Kulka, Janina, and Tőkés, Anna Mária

Subjects
TRIPLE-negative breast cancer, EXTRACELLULAR matrix proteins, BREAST cancer prognosis, OVERALL survival, PROGNOSIS
Abstract

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with a poor prognosis and limited treatment options. This study evaluates the prognostic value of stromal markers in TNBC, focusing on the tumor–stroma ratio (TSR) and overall stroma ratio (OSR) in whole slide images (WSI), as well as the expression of type-I collagen, type-III collagen, and fibrillin-1 on tissue microarrays (TMAs), using both visual assessment and digital image analysis (DIA). A total of 101 female TNBC patients, primarily treated with surgery between 2005 and 2016, were included. We found that high visual OSR correlates with worse overall survival (OS), advanced pN categories, lower stromal tumor-infiltrating lymphocyte count (sTIL), lower mitotic index, and patient age (p < 0.05). TSR showed significant connections to the pN category and mitotic index (p < 0.01). High expression levels of type-I collagen (>45%), type-III collagen (>30%), and fibrillin-1 (>20%) were linked to significantly worse OS (p = 0.004, p = 0.013, and p = 0.005, respectively) and progression-free survival (PFS) (p = 0.028, p = 0.025, and p = 0.002, respectively), validated at the mRNA level. Our results highlight the importance of stromal characteristics in promoting tumor progression and metastasis and that targeting extracellular matrix (ECM) components may offer novel therapeutic strategies. Furthermore, DIA can be more accurate and objective in evaluating TSR, OSR, and immunodetected stromal markers than traditional visual examination. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Revisiting surgical margins for invasive breast cancer patients treated with breast conservation therapy : Evidence for adopting a 1 mm negative width

Author

Rakha, Emad A., Quinnd, Cecily, Masannat, Yazan A., Lee, Andrew H. S., Tang, Puay Hoon, Karakatsanis, Andreas, Matraii, Zoltan Tamas, Al Shaibanii, Salman Husain M., Gehanii, Salahddin A., Shaabanj, Abeer, Khoutl, Hazem, Chagla, Leena, Cserni, Gábor, Varga, Zsuzsanna, Yong, Wong Fuh, Meattini, Icro, Kulka, Janina, Yang, Wentao, Tse, Gary M., Pinder, Sarah E., Fox, Stephen, Dixon, J. Michael, Rakha, Emad A., Quinnd, Cecily, Masannat, Yazan A., Lee, Andrew H. S., Tang, Puay Hoon, Karakatsanis, Andreas, Matraii, Zoltan Tamas, Al Shaibanii, Salman Husain M., Gehanii, Salahddin A., Shaabanj, Abeer, Khoutl, Hazem, Chagla, Leena, Cserni, Gábor, Varga, Zsuzsanna, Yong, Wong Fuh, Meattini, Icro, Kulka, Janina, Yang, Wentao, Tse, Gary M., Pinder, Sarah E., Fox, Stephen, and Dixon, J. Michael

Abstract

Clinical trials have demonstrated conclusively the non-inferiority of breast-conserving surgery followed by breast radiation therapy (BCT) compared with mastectomy for the treatment of early-stage invasive breast cancer (BC). The definition of the required surgical margin to ensure adequate removal of the cancer by BCT to obtain an acceptable low local recurrence (LR) rate remains controversial. Meta-analyses published by Houssami et al. in 2010 and 2014 demonstrated significantly lower LR rates for patients with a negative margin compared with those with positive (ink on tumour) or close (defined as ≤1 mm or ≤2 mm) margins. Neither meta-analysis addressed whether ‘no ink on tumour’ was adequate to define a negative margin because of a lack of data. Nevertheless, in 2014, the Society of Surgical Oncology (SSO) and the American Society for Radiation Oncology (ASTRO) with advice from pathologists reviewed these data together and published guidelines recommending that a margin of ‘no ink on tumour’ was sufficient to define a clear margin in BCT. Subsequently, clinical practice has varied with some national and international bodies endorsing ‘no ink on tumour’, whilst others have recommended a ≥1 mm margin as acceptable margins for BCT. A more recent meta-analysis conducted by Bundred and colleagues in 2022 did have sufficient data to compare ‘no ink on tumour’ and 1 mm and concluded that 1 mm rather than ‘no ink on tumour’, should be used as a minimum negative margin, and recommended that international guidelines be revised. The current review presents a balanced assessment of the evidence relating margin width and local recurrence after BCT. This review concludes that guidelines should consider re-defining a negative margin as ≥1 mm rather than ‘no ink on tumour’ in the context of BCT, recognising there will be variation to tailor therapy for any individual patient situation to ensure optimal patient care.

Published
2024
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18. Revisiting surgical margins for invasive breast cancer patients treated with breast conservation therapy - Evidence for adopting a 1 mm negative width

Author

Rakha, Emad A, Quinn, Cecily, Masannat, Yazan A, Lee, Andrew H S, Tan, Puay Hoon, Karakatsanis, Andreas, Matrai, Zoltan Tamas, Al Shaibani, Salman Husain M, Gehani, Salahddin A, Shaaban, Abeer, Khout, Hazem, Chagla, Leena, Cserni, Gábor, Varga, Zsuzsanna; https://orcid.org/0000-0002-2855-983X, Yong, Wong Fuh, Meattini, Icro, Kulka, Janina, Yang, Wentao, Tse, Gary M, Pinder, Sarah E, Fox, Stephen, Dixon, J Michael, Rakha, Emad A, Quinn, Cecily, Masannat, Yazan A, Lee, Andrew H S, Tan, Puay Hoon, Karakatsanis, Andreas, Matrai, Zoltan Tamas, Al Shaibani, Salman Husain M, Gehani, Salahddin A, Shaaban, Abeer, Khout, Hazem, Chagla, Leena, Cserni, Gábor, Varga, Zsuzsanna; https://orcid.org/0000-0002-2855-983X, Yong, Wong Fuh, Meattini, Icro, Kulka, Janina, Yang, Wentao, Tse, Gary M, Pinder, Sarah E, Fox, Stephen, and Dixon, J Michael

Abstract

Clinical trials have demonstrated conclusively the non-inferiority of breast-conserving surgery followed by breast radiation therapy (BCT) compared with mastectomy for the treatment of early-stage invasive breast cancer (BC). The definition of the required surgical margin to ensure adequate removal of the cancer by BCT to obtain an acceptable low local recurrence (LR) rate remains controversial. Meta-analyses published by Houssami et al. in 2010 and 2014 demonstrated significantly lower LR rates for patients with a negative margin compared with those with positive (ink on tumour) or close (defined as ≤1 mm or ≤2 mm) margins. Neither meta-analysis addressed whether 'no ink on tumour' was adequate to define a negative margin because of a lack of data. Nevertheless, in 2014, the Society of Surgical Oncology (SSO) and the American Society for Radiation Oncology (ASTRO) with advice from pathologists reviewed these data together and published guidelines recommending that a margin of 'no ink on tumour' was sufficient to define a clear margin in BCT. Subsequently, clinical practice has varied with some national and international bodies endorsing 'no ink on tumour', whilst others have recommended a ≥1 mm margin as acceptable margins for BCT. A more recent meta-analysis conducted by Bundred and colleagues in 2022 did have sufficient data to compare 'no ink on tumour' and 1 mm and concluded that 1 mm rather than 'no ink on tumour', should be used as a minimum negative margin, and recommended that international guidelines be revised. The current review presents a balanced assessment of the evidence relating margin width and local recurrence after BCT. This review concludes that guidelines should consider re-defining a negative margin as ≥1 mm rather than 'no ink on tumour' in the context of BCT, recognising there will be variation to tailor therapy for any individual patient situation to ensure optimal patient care.

Published
2024

30. Role of the kisspeptin-KISS1R axis in the pathogenesis of chronic kidney disease and uremic cardiomyopathy

Author

Dinh, Hoa, primary, Kovács, Zsuzsanna Z. A., additional, Kis, Merse, additional, Kupecz, Klaudia, additional, Sejben, Anita, additional, Szűcs, Gergő, additional, Márványkövi, Fanni, additional, Siska, Andrea, additional, Freiwan, Marah, additional, Pósa, Szonja Polett, additional, Galla, Zsolt, additional, Ibos, Katalin Eszter, additional, Bodnár, Éva, additional, Lauber, Gülsüm Yilmaz, additional, Goncalves, Ana Isabel Antunes, additional, Acar, Eylem, additional, Kriston, András, additional, Kovács, Ferenc, additional, Horváth, Péter, additional, Bozsó, Zsolt, additional, Tóth, Gábor, additional, Földesi, Imre, additional, Monostori, Péter, additional, Cserni, Gábor, additional, Podesser, Bruno K., additional, Lehoczki, Andrea, additional, Pokreisz, Peter, additional, Kiss, Attila, additional, Dux, László, additional, Csabafi, Krisztina, additional, and Sárközy, Márta, additional

Published
2023
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32. Breast lesions with myoepithelial phenotype

Author

Foschini, Maria P, Nishimura, Rieko, Fabbri, Viscardo Paolo, Varga, Zsuzsanna, Kaya, Handan, Cserni, Gábor, and University of Zurich

Subjects
Histology, 10049 Institute of Pathology and Molecular Pathology, 03.01. Általános orvostudomány, 610 Medicine & health, General Medicine, Pathology and Forensic Medicine
Abstract

Myoepithelial cells (MECs) constitute a continuous layer of cells surrounding the breast glands, localised between the epithelial cells (ECs) and the basal membrane. MECs play important roles in normal mammary gland as they produce basal membrane and stimulate secretion. During neoplastic transformation, MECs act as a barrier preventing stromal invasion. MECs themselves can undergo a great variety of changes, ranging from hyperplastic to metaplastic, to neoplastic, and giving rise to a wide spectrum of morphological pictures sometimes difficult to interpret on routine diagnoses. Several benign and malignant breast tumours can present features of MECs differentiation. As these latter tumours are quite infrequent, the purpose of the present study is to offer a review of the morphological spectrum of MECs lesions, with correlations to prognosis.

Published
2022
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40. Chronic kidney disease induces left ventricular overexpression of the pro-hypertrophic microRNA-212

Author

Sárközy, Márta, Gáspár, Renáta, Zvara, Ágnes, Siska, Andrea, Kővári, Bence, Szűcs, Gergő, Márványkövi, Fanni, Kovács, Mónika G., Diószegi, Petra, Bodai, László, Zsindely, Nóra, Pipicz, Márton, Gömöri, Kamilla, Kiss, Krisztina, Bencsik, Péter, Cserni, Gábor, Puskás, László G., Földesi, Imre, Thum, Thomas, Bátkai, Sándor, and Csont, Tamás

Published
2019
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41. ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations

Author

Cserni, Bálint, Kilmartin, Darren, O’Loughlin, Mark, Andreu, Xavier, Bagó-Horváth, Zsuzsanna, Bianchi, Simonetta, Chmielik, Ewa, Figueiredo, Paulo, Floris, Giuseppe, Foschini, Maria Pia, Kovács, Anikó, Heikkilä, Päivi, Kulka, Janina, Laenkholm, Anne Vibeke, Liepniece-Karele, Inta, Marchiò, Caterina, Provenzano, Elena, Regitnig, Peter, Reiner, Angelika, Ryška, Aleš, Sapino, Anna, Stovgaard, Elisabeth Specht, Quinn, Cecily, Zolota, Vasiliki, Webber, Mark, Glynn, Sharon A., Bori, Rita, Csörgő, Erika, Oláh-Németh, Orsolya, Pancsa, Tamás, Sejben, Anita, Sejben, István, Vörös, András, Zombori, Tamás, Nyári, Tibor, Callagy, Grace, Cserni, Gábor, Cserni, Bálint, Kilmartin, Darren, O’Loughlin, Mark, Andreu, Xavier, Bagó-Horváth, Zsuzsanna, Bianchi, Simonetta, Chmielik, Ewa, Figueiredo, Paulo, Floris, Giuseppe, Foschini, Maria Pia, Kovács, Anikó, Heikkilä, Päivi, Kulka, Janina, Laenkholm, Anne Vibeke, Liepniece-Karele, Inta, Marchiò, Caterina, Provenzano, Elena, Regitnig, Peter, Reiner, Angelika, Ryška, Aleš, Sapino, Anna, Stovgaard, Elisabeth Specht, Quinn, Cecily, Zolota, Vasiliki, Webber, Mark, Glynn, Sharon A., Bori, Rita, Csörgő, Erika, Oláh-Németh, Orsolya, Pancsa, Tamás, Sejben, Anita, Sejben, István, Vörös, András, Zombori, Tamás, Nyári, Tibor, Callagy, Grace, and Cserni, Gábor

Abstract

Tumour-infiltrating lymphocytes (TILs) reflect antitumour immunity. Their evaluation of histopathology specimens is influenced by several factors and is subject to issues of reproducibility. ONEST (Observers Needed to Evaluate Subjective Tests) helps in determining the number of observers that would be sufficient for the reliable estimation of inter-observer agreement of TIL categorisation. This has not been explored previously in relation to TILs. ONEST analyses, using an open-source software developed by the first author, were performed on TIL quantification in breast cancers taken from two previous studies. These were one reproducibility study involving 49 breast cancers, 23 in the first circulation and 14 pathologists in the second circulation, and one study involving 100 cases and 9 pathologists. In addition to the estimates of the number of observers required, other factors influencing the results of ONEST were examined. The analyses reveal that between six and nine observers (range 2–11) are most commonly needed to give a robust estimate of reproducibility. In addition, the number and experience of observers, the distribution of values around or away from the extremes, and outliers in the classification also influence the results. Due to the simplicity and the potentially relevant information it may give, we propose ONEST to be a part of new reproducibility analyses.

Published
2023

43. Genomic Landscape of Normal and Breast Cancer Tissues in a Hungarian Pilot Cohort

Author

Pipek, Orsolya, primary, Alpár, Donát, additional, Rusz, Orsolya, additional, Bödör, Csaba, additional, Udvarnoki, Zoltán, additional, Medgyes-Horváth, Anna, additional, Csabai, István, additional, Szállási, Zoltán, additional, Madaras, Lilla, additional, Kahán, Zsuzsanna, additional, Cserni, Gábor, additional, Kővári, Bence, additional, Kulka, Janina, additional, and Tőkés, Anna Mária, additional

Published
2023
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48. Prognostic Markers of Microinvasive Breast Carcinoma: A Systematic Review and Meta-Analysis

Author

Ambrosini-Spaltro Andrea, Di Donato Francesco, Saragoni Luca, Cserni Gábor, Rakha Emad, and Foschini Maria Pia

Subjects
03.02. Klinikai orvostan
Abstract

(1) Background: The prognostic factors of microinvasive (≤1 mm) breast carcinoma are not completely clear. The aim of this study was to perform a systematic review and meta-analysis to clarify these factors. (2) Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology was followed. Two databases were interrogated, PubMed and Embase, and papers in English were included to address this question. The selected studies were those that reported on female patients affected by microinvasive carcinoma, and on prognostic factors with a hazard ratio (HR) for disease-free survival (DFS) and overall survival (OS). (3) Results: In total, 618 records were identified. After removing duplicates (166), identification, and screening (336 by title and abstract alone, 116 by full text and eventual supplementary material), 5 papers were selected. Seven different meta-analyses were conducted in this study, all referring to DFS, analyzing the following prognostic factors: estrogen receptor, progesterone receptor, HER2 status, multifocality and grade of microinvasion, patient’s age, and lymph node status. Only lymph node status was associated with prognosis and DFS (total number of cases: 1528; Z = 1.94; p = 0.05). The other factors examined did not significantly affect prognosis (p > 0.05). (4) Conclusions: Positive lymph node status significantly worsens prognosis in patients with microinvasive breast carcinoma.

Published
2023
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50. ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations

Author

Cserni, Bálint, primary, Kilmartin, Darren, additional, O’Loughlin, Mark, additional, Andreu, Xavier, additional, Bagó-Horváth, Zsuzsanna, additional, Bianchi, Simonetta, additional, Chmielik, Ewa, additional, Figueiredo, Paulo, additional, Floris, Giuseppe, additional, Foschini, Maria Pia, additional, Kovács, Anikó, additional, Heikkilä, Päivi, additional, Kulka, Janina, additional, Laenkholm, Anne-Vibeke, additional, Liepniece-Karele, Inta, additional, Marchiò, Caterina, additional, Provenzano, Elena, additional, Regitnig, Peter, additional, Reiner, Angelika, additional, Ryška, Aleš, additional, Sapino, Anna, additional, Stovgaard, Elisabeth Specht, additional, Quinn, Cecily, additional, Zolota, Vasiliki, additional, Webber, Mark, additional, Glynn, Sharon A., additional, Bori, Rita, additional, Csörgő, Erika, additional, Oláh-Németh, Orsolya, additional, Pancsa, Tamás, additional, Sejben, Anita, additional, Sejben, István, additional, Vörös, András, additional, Zombori, Tamás, additional, Nyári, Tibor, additional, Callagy, Grace, additional, and Cserni, Gábor, additional

Published
2023
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