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Previous studies on the academic achievement (AA) of students who pursue education in English-medium instruction settings indicate that standardised international language tests demonstrate low predictive power for study success. Consequently, there seems to be clear value in exploring alternative means of determining influential correlators between language proficiency and academic performance, especially in countries where international tests are neither a prerequisite for university admission nor a cost-effective option. This study explored Hungarian native-speakers, members of a linguistic minority living in Romania, studying for a degree in English Language and Literature. English (L3) and Romanian (L2) form-meaning based receptive vocabulary tests have been employed to explore the extent to which they predict AA. The results show significant positive correlations between lexical knowledge in the tested languages and AA. However, regression analyses indicate that English vocabulary scores emerge as the best single predictors and explain over 30% of variance. This suggests that, in the case of typologically close languages, lexical tests are likely measuring the same underlying trait. Given the relatively high predictive power of vocabulary tests in relation to AA, we conclude that lexical knowledge is an important explanatory factor of AA, even in the case of multilinguals.

The FORESEE is an open access, climatological database for Central Europe containing observed and projected meteorological data for the 1951–2100 period. As a climate service, FORESEE disseminates basic meteorological variables at a daily time step with a 0.1° × 0.1° spatial resolution including maximum/minimum temperature, precipitation, incoming shortwave solar radiation and daylight vapour pressure deficit. The future climate in FORESEE v4.0 and FORESEE-HUN v1.0 is projected by 14 regional climate models from the EURO-CORDEX database using the Representative Concentration Pathways (RCP) 4.5 and 8.5 scenarios. Based on RCP4.5 the country-specific results indicate similar projected mean changes in annual mean temperature (1.5–1.7 °C) but considerable differences in precipitation (from −1.6 to 6.9%) in the region for 2071–2100 relative to 1991–2020. We present two case studies to demonstrate the applicability of FORESEE in climate change impact studies using the ensemble approach. Climate change induced negative weather effect (15.4% and 28.9% mean loss for 2071–2100 according to RCP4.5 and RCP8.5, respectively) might dominate the future winter wheat yields in Hungary that is superimposed to the overall trend determined by other factors. The projections provide consistent results about the mean advance in the start of the growing season for forests in Hungary up to 2100 with ensemble mean of 9.1 days (RCP4.5) and 19.8 days (RCP8.5). We also demonstrate that the representative model selection method might lead to misleading results in impact studies that should be considered. The updated FORESEE is a way forward in the dissemination of policy-relevant essential climate data in Central Europe.

Aims: Impairment of blood–brain barrier (BBB) is involved in numerous neurological diseases from developmental to aging stages. Reliable imaging of increased BBB permeability is therefore crucial for basic research and preclinical studies. Today, the analysis of extravasation of exogenous dyes is the principal method to study BBB leakage. However, these procedures are challenging to apply in pups and embryos and may appear difficult to interpret. Here we introduce a novel approach based on agonist‐induced internalization of a neuronal G protein‐coupled receptor widely distributed in the mammalian brain, the somatostatin receptor type 2 (SST2). Methods: The clinically approved SST2 agonist octreotide (1 kDa), when injected intraperitoneally does not cross an intact BBB. At sites of BBB permeability, however, OCT extravasates and induces SST2 internalization from the neuronal membrane into perinuclear compartments. This allows an unambiguous localization of increased BBB permeability by classical immunohistochemical procedures using specific antibodies against the receptor. Results: We first validated our approach in sensory circumventricular organs which display permissive vascular permeability. Through SST2 internalization, we next monitored BBB opening induced by magnetic resonance imaging‐guided focused ultrasound in murine cerebral cortex. Finally, we proved that after intraperitoneal agonist injection in pregnant mice, SST2 receptor internalization permits analysis of BBB integrity in embryos during brain development. Conclusions: This approach provides an alternative and simple manner to assess BBB dysfunction and development in different physiological and pathological conditions. [ABSTRACT FROM AUTHOR]

In Romanian media, Szeklerland — a region in Central Romania with an ethnic Hungarian majority – is often evoked as a troublesome part of the country, where Romanians are discriminated against and Hungarian separatism undermines the authority of the state. This representation has endured since the fall of Communism in 1989, even though — unlike in other regions of Europe — the local Hungarian autonomist movement has always relied on peaceful means. The mainstream Romanian discourse, with its focus on the political efforts of Hungarian parties, the symbolic rivalry between Hungarian and Romanian elites, and the fight for economic resources has largely been unchanged. This conflict-oriented perspective makes for a skewed and ethnicized representation of Szeklerland, portrayed as an ‘intolerant region’. While the region witnessed only a minor Hungarian–Romanian conflict in March 1990, the topics of instability and constant tension pervaded the media discourse regarding Szeklerland during the 1990s. Even though the dominant nationalist discourse has become less virulent, this pattern has persisted with the advent of digital and new media formats. Many contemporary representations of Szeklerland on commercial television and social media platforms keep reproducing the stereotypes inherited from the 1990s. This article is based on a historical approach, and, through the analysis of several recent Romanian short documentary films about the Szekler area, highlights the reproduction of the region’s imagery and the most common strategies that feed this polarizing representation.

The subjects of this analysis are normative acts and their practical applications in the protection of wild flora and fauna, that is, international and Hungarian regulations on the protection of nature. Naturally, the laws on protecting the environment are much wider in scope than the subject matter of this article, as they include the protection of the elements that constitute the environment as well as sanctions regarding behaviours related to waste disposal. In describing the regulations that protect the environment, we have primarily focused on analysing the criminal law situation. Then, we present the regulatory solutions of the European Union and international law in detail, with an accompanying analysis of the most important international organizations. The final part of this paper is dedicated to a description of the domestic organizations charged with processing criminal offences against the environment.

In my paper I focused on the anniversary of the Romanian "Great Union" (The Declaration of Alba Iulia, 1. 12. 1918) and of the Hungarian signing of the Trianon Peace Treaty (4. 6. 1920). Although these two anniversaries are closely connected, they play very different roles in the national narratives and in the collective memories of Romanians and Hungarians. No wonder that also the ways and aims of their commemoration are significantly different. First, I tried to explain in short what had happened on those two dates a century ago, then I sum up the history of the two anniversaries along the 20th century, and finally I took a look at their commemoration and instrumentalization in the present, with the occasion of the centenary.

This study provided a novel flipped classroom model with a detailed combination of in-class and out-of-class activities to teach a Vietnamese-English Translation module. The study aimed to (1) provide an in-depth insight into how the model was actually implemented in a specific scenario to make the teaching-learning process more interesting and meaningful, and (2) investigate the effectiveness of the flipped classroom model towards learners’ translation performance through various assessments. 39 English-majored juniors at Banking University of Ho Chi Minh City, Vietnam participated in the study during the second semester of the 2018-2019 academic year. The study implemented a case-study mixed method design, applying assessment analysis and content analysis of one specific learning scenario to clarify how the flipped learning model contributed to the training process. Results show that a careful design of the flipped model contributed to the relevant literature on how to implement flipped learning in actual classroom settings, but also effectively improved learners’ performance in translation studies.

We report on an 11-year-old girl with cystic fibrosis who presented with thoracic pain and an extensive subcutaneous emphysema and subsequently developed progressive respiratory distress. The chest computed tomography revealed a huge pneumomediastinum. Due to the development of severe respiratory failure, urgent needle thoracocentesis was necessary that resulted in only temporary improvement. Therefore, under general anesthesia two mediastinal drains were introduced. Using active suction, the size of the pneumomediastinum decreased gradually and the drains were removed after 3 weeks. Here, we describe an extremely rare situation, when acute surgical intervention was necessary in a child with spontaneous pneumomediastinum.

Abstract Purpose The revision of any total knee replacement is carried out in a significant number of cases, due to the excessive internal rotation of the tibial component. The goal was to develop a personalized method, using only the geometric parameters of the tibia, without the femoral guidelines, to calculate the postoperative rotational position of tibial component malrotation within a tolerable error threshold in every case. Methods Preoperative CT scans of eighty‐five osteoarthritic knees were examined by three independent medical doctors twice over 7 weeks. The geometric centre of the tibia was produced by the ellipse annotation drawn 8 mm below the tibial plateau, the sagittal and frontal axes of the ellipse were transposed to the slice of the tibial tuberosity. With the usage of several guide lines, a right triangle was drawn within which the personalized Berger angle was calculated. Results A very good intra‐observer (0.89‐0.925) and inter‐observer (0.874) intra‐class correlation coefficient (ICC) was achieved. Even if the average of the personalized Berger values were similar to the original 18° (18.32° in our case), only 70.6% of the patients are between the clinically tolerable thresholds (12.2° and 23.8°). Conclusion The method, measured on the preoperative CT scans, is capable of calculating the required correction during the planning of revision arthroplasties which are necessary due to the tibial component malrotation. The personalized Berger angle isn’t altered during arthroplasty, this way it determines which one of the anterior reference points of the tibia (medial 1/3 or the tip of the tibial tuberosity, medial border or 1/6 or 1/3 or the centre of the patellar tendon) can be used during the positioning of the tibial component. Level of evidence Level II, Diagnostic Study (Methodological Study).

A szerző tanulmányában megvizsgálja a nemzetközi szervezett bűnözéssel és a bűnszervezetekkel kapcsolatos főbb elméleteket, empirikus kutatásokon alapuló eredményeket, illetve a bűnszervezetek nemzetközi és hatályos jogi meghatározásait. A tanulmány célja rámutatni, hogy mennyiben alkalmazhatók a jogi meghatározások a kutatások által feltárt különböző felépítésű bűnszervezettípusokra. Ennek érdekében széles körű áttekintést nyújt a nemzetközi és hazai elméleti megközelítésekről és kutatások eredményeiről, illetve ennek megfelelően elemzi a nemzetközi és hazai jogi szabályozást. A kutatások eredményei szerint a nemzetközi szervezett bűnözői csoportok sokféleséget mutatnak, eltérő jellegzetességek jellemzők a struktúra, cél, összetétel és egyéb tekintetben. Ennek megfelelően a cikk rámutat arra, hogy a nemzetközi meghatározások kellően tágak és alkalmazhatók a különböző típusú nemzetközi bűnszervezetekre, míg a szerző megállapítása szerint a hazai jogi meghatározás eléggé szűken értelmezhető, abból indokolatlanul kiszorul a sokszínűséget mutató nemzetközi szervezett bűnözői csoportok nagy része.

Ebben a cikkben megvizsgálom a régi és a hatályos magyar büntetőeljárási törvény bizonyítási tilalmakra vonatkozó rendelkezéseit. A jogszabály elemzés célja egyrészt megállapítani, hogy a 2018. július 01-én hatályba lépett törvény mennyiben változtathatja meg a korábbi nyomozási gyakorlatot, másrészt felmerülhetnek-e jogértelmezési problémák a jogalkalmazók körében. Az elemzéshez gyakorlati példákat hoztam, melyeket több mint 20 éves bűnügyi nyomozói és vizsgálói múltamból merítettem. Az elemzés alapján megállapítottam, hogy a törvényi szabályozás egyértelmű és nagyrészt alkalmazható, azonban bizonyos tekintetben kiegészítésre vagy további értelmezésre szorul.

Very small glaciers (2) account for more than 80% of the total number of glaciers and more than 15% of the total glacier area in the European Alps. This study seeks to better understand the impact of extreme snowfall events on the resilience of very small glaciers and ice patches in the southeastern European Alps, an area with the highest mean annual precipitation in the entire Alpine chain. Mean annual precipitation here is up to 3300 mm water equivalent, and the winter snow accumulation is approximately 6.80 m at 1800 m asl averaged over the period 1979–2018. As a consequence, very small glaciers and ice/firn patches are still present in this area at rather low altitudes (1830–2340 m). We performed repeated geodetic mass balance measurements on 14 ice bodies during the period 2006–2018 and the results show an increase greater than 10% increase in ice volume over this period. This is in accordance with several extreme winter snow accumulations in the 2000s, promoting a positive mass balance in the following years. The long-term evolution of these very small glaciers and ice bodies matches well with changes in mean temperature of the ablation season linked to variability of Atlantic Multidecadal Oscillation. Nevertheless, the recent behaviour of such residual ice masses in this area where orographic precipitation represents an important component of weather amplification is somehow different to most of the Alps. We analysed synoptic meteorological conditions leading to the exceptional snowy winters in the 2000s, which appear to be related to the influence and modification of atmospheric planetary waves and Arctic Amplification, with further positive feedbacks due to change in local sea surface temperature and its interactions with low level flows and the orography. Although further summer warming is expected in the next decades, we conclude that modification of storm tracks and more frequent occurrence of extreme snowfall events during winter are crucial in ensuring the resilience of small glacial remnants in maritime alpine sectors.

A szerző áttekintést nyújt a magyar büntető igazságszolgáltatás reintegrációs törvényének és politikájának legújabb fejleményeiről.

Professor of History, István Rugonfalvi Kiss served as Rector Magnificus of the Hungarian Royal István Tisza University of Debrecen in the academic year of 1932-1933. A historian of Székely origin, he first served as the local archivist of the Baron Radvánszky family estate, then he acquired a growing reputation as the chief archivists of Győr County. Starting in 1911, he became college professor of history at the Arts Academy of the Debrecen Protestant College, then from 1914 until his retirement in 1942 he served as professor of Hungarian history of the newly established University of Debrecen. He served as dean several times and he was appointed Rector of the University in the academic year of 1932-1933. In historical scholarship he represented the conservative alternative, thus he was violently opposed to Gyula Szekfű’s view of history. He is the author of work on the last Hungarian uprising of noblemen as well as on the history of the Székely people. After the the Second World War, owing to his previous political activism, he was imprisoned and subsequently he lived in the circle of his family, isolated from professional activity.

Neurokinin (NK) signaling is involved in various inflammatory processes. A common manifestation of systemic inflammation is fever, which is usually induced in animal models with the administration of bacterial lipopolysaccharide (LPS). A role for the NK1 receptor was shown in LPS-induced fever, but the underlying mechanisms of how the NK1 receptor contributes to febrile response, especially in the early phase, have remained unknown. We administered LPS (120 µg/kg, intraperitoneally) to mice with the Tacr1 gene, i.e., the gene encoding the NK1 receptor, either present (Tacr1+/+) or absent (Tacr1−/−) and measured their thermoregulatory responses, serum cytokine levels, tissue cyclooxygenase-2 (COX-2) expression, and prostaglandin (PG) E2 concentration. We found that the LPS-induced febrile response was attenuated in Tacr1−/− compared to their Tacr1+/+ littermates starting from 40 min postinfusion. The febrigenic effect of intracerebroventricularly administered PGE2 was not suppressed in the Tacr1−/− mice. Serum concentration of pyrogenic cytokines did not differ between Tacr1−/− and Tacr1+/+ at 40 min post-LPS infusion. Administration of LPS resulted in amplification of COX-2 mRNA expression in the lungs, liver, and brain of the mice, which was statistically indistinguishable between the genotypes. In contrast, the LPS-induced augmentation of COX-2 protein expression was attenuated in the lungs and tended to be suppressed in the liver of Tacr1−/− mice compared with Tacr1+/+ mice. The Tacr1+/+ mice responded to LPS with a significant surge of PGE2 production in the lungs, whereas Tacr1−/− mice did not. In conclusion, the NK1 receptor is necessary for normal fever genesis. Our results suggest that the NK1 receptor contributes to the early phase of LPS-induced fever by enhancing COX-2 protein expression in the periphery. These findings advance the understanding of the crosstalk between NK signaling and the “cytokine-COX-2-prostaglandin E2” axis in systemic inflammation, thereby open up the possibilities for new therapeutic approaches.

Benign biliary stricture is a rare condition and the majority of the cases are caused by operative trauma or chronic inflammation based on various etiology. Although the initial results of endoscopic, percutaneous and surgical treatment are impressive, no comparison about long term stricture resolution is available.The goal of this study was to compare the long term disease free survival in benign biliary strictures with various etiology after surgery, percutaneous transhepatic-and endoscopic treatment.PubMed, Embase, and Cochrane Library were searched by computer and manually for published studies. The investigators selected the publications according to the inclusion and exclusion criteria, processed the data and assessed the quality of the selected studies. Meta-analysis of data of 24 publications was performed to compare long term disease free survival of different treatment groups.Compared the subgroups surgery resulted in the highest long term stricture resolution rate, followed by the percutaneous transhepatic treatment, the multiple plastic stent insertion and covered self-expanding metal stents (SEMS), however the difference was not significant. All compared methods are significantly superior to the single plastic stent placement. Long term stricture resolution rate irrespectively of any therapy is still not more than 84%.In summary, the use of single plastic stent is not recommended. Further randomized studies and innovative technical development are required for improving the treatment of benign biliary strictures.

Leptin is one of the major adipokines in obesity that indicates the severity of fat accumulation. It is also an important etiological factor of consequent cardiometabolic and autoimmune disorders. Aging has been demonstrated to aggravate obesity and to induce leptin resistance and hyperleptinemia. Hyperleptinemia, on the other hand, may promote the development of age-related abnormalities. While major weight loss has been demonstrated to ameliorate hyperleptinemia, obese people show a poor tendency to achieve lasting success in this field. The question arises whether training intervention per se is able to reduce the level of this adipokine.We aimed to review the literature on the effects of training intervention on peripheral leptin level in obesity during aging, in order to evaluate the independent efficacy of this method. In the studies that were included in our analysis, changes of adiponectin levels (when present) were also evaluated.3481 records were identified through searching of PubMed, Embase and Cochrane Library Database. Altogether 19 articles were suitable for analyses.Empirical research papers were eligible provided that they reported data of middle-aged or older (above 45 years of age) overweight or obese (body mass index above 25) individuals and included physical training intervention or at least fitness status of groups together with corresponding blood leptin values.We used random effect models in each of the meta-analyses calculating with the DerSimonian and Laird weighting methods. I-squared indicator and Q test were performed to assess heterogeneity. To assess publication bias Egger's test was applied. In case of significant publication bias, the Duval and Tweedie's trim and fill algorithm was used.Training intervention leads to a decrease in leptin level of middle-aged or older, overweight or obese male and female groups, even without major weight loss, indicated by unchanged serum adiponectin levels. Resistance training appears to be more efficient in reducing blood leptin level than aerobic training alone.Physical training, especially resistance training successfully reduces hyperleptinemia even without diet or major weight loss.

BACKGROUND:Sepsis is usually accompanied by changes of body temperature (Tb), but whether fever and hypothermia predict mortality equally or differently is not fully clarified. We aimed to find an association between Tb and mortality in septic patients with meta-analysis of clinical trials. METHODS:We searched the PubMed, EMBASE, and Cochrane Controlled Trials Registry databases (from inception to February 2016). Human studies reporting Tb and mortality of patients with sepsis were included in the analyses. Average Tb with SEM and mortality rate of septic patient groups were extracted by two authors independently. RESULTS:Forty-two studies reported Tb and mortality ratios in septic patients (n = 10,834). Pearson correlation analysis revealed weak negative linear correlation (R2 = 0.2794) between Tb and mortality. With forest plot analysis, we found a 22.2% (CI, 19.2-25.5) mortality rate in septic patients with fever (Tb > 38.0°C), which was higher, 31.2% (CI, 25.7-37.3), in normothermic patients, and it was the highest, 47.3% (CI, 38.9-55.7), in hypothermic patients (Tb < 36.0°C). Meta-regression analysis showed strong negative linear correlation between Tb and mortality rate (regression coefficient: -0.4318; P < 0.001). Mean Tb of the patients was higher in the lowest mortality quartile than in the highest: 38.1°C (CI, 37.9-38.4) vs 37.1°C (CI, 36.7-37.4). CONCLUSIONS:Deep Tb shows negative correlation with the clinical outcome in sepsis. Fever predicts lower, while hypothermia higher mortality rates compared with normal Tb. Septic patients with the lowest (< 25%) chance of mortality have higher Tb than those with the highest chance (> 75%).

A szerző áttekintést nyújt a rendőrök lőfegyver használatának jogi és gyakorlati kereteiről Magyarországon.