Search

Abstract We present an extension of the GM2Calc software to calculate the muon anomalous magnetic moment ( $${a_\mu ^{{\text {BSM}}}}$$ a μ BSM ) in the Two-Higgs Doublet Model. The Two-Higgs Doublet Model is one of the simplest and most popular extensions of the Standard Model. It is one of the few single field extensions that can give large contributions to $${a_\mu ^{{\text {BSM}}}}$$ a μ BSM . It is essential to include two-loop corrections to explain the long standing discrepancy between the Standard Model prediction and the experimental measurement in the Two-Higgs Doublet Model. The new version GM2Calc 2 implements the state of the art two-loop calculation for the general, flavour violating Two-Higgs Doublet Model as well as for the flavour aligned Two-Higgs Doublet Model and the type I, II, X and Y flavour conserving variants. Input parameters can be provided in either the gauge basis or the mass basis, and we provide an easy to use SLHA-like command-line interface to specify these. Using this interface users may also select between Two-Higgs Doublet Model types and choose which contributions to apply. In addition, GM2Calc 2 also provides interfaces in C++, C, Python and Mathematica, to make it easy to interface with other codes.

Abstract We present a likelihood analysis of the general two Higgs doublet model, using the most important currently measured flavour observables, in view of the anomalies in charged current tree-level and neutral current one-loop rare decays of B mesons in b → cl ν ¯ $$ \overline{\nu} $$ and b → sμ + μ − transitions, respectively. We corroborate that the model explains the latter and it is able to simultaneously fit the experimental values of the R(D) charged current ratio at 1σ, but it can not accommodate the D * charmed meson observables R(D *) and F L (D *). We find that the fitted values for the angular observables in b → sμ + μ − transitions exhibit better agreement with the general two Higgs double model in comparison to the SM. We also make predictions for future collider observables BR(t → ch), BR(h → bs), BR(h → τμ), BR(B s → τ + τ − ), BR(B + → K + τ + τ − ) and the flavour violating decays of the τ lepton, BR(τ → 3μ) and BR(τ → μγ). The model predicts values of BR(t → ch), BR(B s → τ + τ − ) and BR(B + → K + τ + τ − ) that are out of reach of future experiments, but its predictions for BR(h → bs) and BR(h → τμ) are within the future sensitivity of the HL-LHC or the ILC. We also find that the predictions for the τ → 3μ and τ → μγ decays are well within the projected limits of the Belle II experiment. Finally, using the latest measurement of the Fermilab Muon g − 2 Collaboration, we performed a simultaneous fit to ∆a μ constrained by the charged anomalies, finding solutions at the 1σ level. Once the neutral anomalies are included, however, a simultaneous explanation is unfeasible.

Abstract Motivated by the fact that the Next-to-Minimal Supersymmetric Standard Model is one of the most plausible models that can accommodate electroweak baryogenesis, we analyze its phase structure by tracing the temperature dependence of the minima of the effective potential. Our results reveal rich patterns of phase structure that end in the observed electroweak symmetry breaking vacuum. We classify these patterns according to the first transition in their history and show the strong first-order phase transitions that may be possible in each type of pattern. These could allow for the generation of the matter-antimatter asymmetry or potentially observable gravitational waves. For a selection of benchmark points, we checked that the phase transitions completed and calculated the nucleation temperatures. We furthermore present samples that feature strong first-order phase transitions from an extensive scan of the whole parameter space. We highlight common features of our samples, including the fact that the Standard Model like Higgs is often not the lightest Higgs in the model.

Abstract In Ref. (GAMBIT Collaboration: Athron et. al., Eur. Phys. J. C. arXiv:1705.07908, 2017) we introduced the global-fitting framework GAMBIT. In this addendum, we describe a new minor version increment of this package. GAMBIT 1.1 includes full support for Mathematica backends, which we describe in some detail here. As an example, we backend SUSYHD (Vega and Villadoro, JHEP 07:159, 2015), which calculates the mass of the Higgs boson in the MSSM from effective field theory. We also describe updated likelihoods in PrecisionBit and DarkBit, and updated decay data included in DecayBit.

Abstract The Dark Matter Particle Explorer (DAMPE) recently released measurements of the electron spectrum with a hint of a narrow peak at about 1.4 TeV. We investigate dark matter (DM) models that could produce such a signal by annihilation in a nearby subhalo whilst simultaneously satisfying constraints from DM searches. In our model-independent approach, we consider all renormalizable interactions via a spin 0 or 1 mediator between spin 0 or 1/2 DM particles and the Standard Model leptons. We find that of the 20 combinations, 10 are ruled out by velocity or helicity suppression of the annihilation cross section to fermions. The remaining 10 models, though, evade constraints from the relic density, collider and direct detection searches, and include models of spin 0 and 1/2 DM coupling to a spin 0 or 1 mediator. We delineate the regions of mediator mass and couplings that could explain the DAMPE excess. In all cases the mediator is required to be heaver than about 2 TeV by LEP limits.

Abstract We describe the open-source global fitting package GAMBIT: the Global And Modular Beyond-the-Standard-Model Inference Tool. GAMBIT combines extensive calculations of observables and likelihoods in particle and astroparticle physics with a hierarchical model database, advanced tools for automatically building analyses of essentially any model, a flexible and powerful system for interfacing to external codes, a suite of different statistical methods and parameter scanning algorithms, and a host of other utilities designed to make scans faster, safer and more easily-extendible than in the past. Here we give a detailed description of the framework, its design and motivation, and the current models and other specific components presently implemented in GAMBIT. Accompanying papers deal with individual modules and present first GAMBIT results. GAMBIT can be downloaded from gambit.hepforge.org .

Abstract The Higgs boson discovery stirred interest in next-to-minimal supersymmetric models, due to the apparent fine-tuning required to accommodate it in minimal theories. To assess their naturalness, we compare fine-tuning in a ℤ3 conserving semi-constrained Next-to-Minimal Supersymmetric Standard Model (NMSSM) to the constrained MSSM (CMSSM). We contrast popular fine-tuning measures with naturalness priors, which automatically appear in statistical measures of the plausibility that a given model reproduces the weak scale. Our comparison shows that naturalness priors provide valuable insight into the hierarchy problem and rigorously ground naturalness in Bayesian statistics. For the CMSSM and semi-constrained NMSSM we demonstrate qualitative agreement between naturalness priors and popular fine tuning measures. Thus, we give a clear plausibility argument that favours relatively light superpartners.

Introduction: Acute ischemic strokes (AIS) due to tandem occlusion (TO) of intracranial anterior large vessel and concomitant extracranial internal carotid artery (EICA) are represent in 15–20% of all ischemic strokes. The endovascular treatment (EVT) strategy for those patients is still unclear. Although the intracranial mechanical thrombectomy (MT) is considered as a standard treatment approach, the EICA lesion stent necessity remains a matter of debate. We sought to assess the efficacy and safety of EVT in tandem lesions, particularly the EICA stenting management. Methods: We retrospectively analyzed all patients with anterior circulation stroke associated with EICA lesion and receiving EVT in the three participated stroke centers between November 2017 and December 2020. Patients’ data were collected from our prospective stroke registry (STAY ALIVE). Patients enrolled in our study were divided into two groups depending on whether acute carotid stenting (ACS) or balloon angioplasty only (BAO) technique was used. Our primary outcome was the 90-day functional outcome assessed by modified Rankin scale (mRS). Mortality at 90 days and symptomatic intracranial hemorrhage (sICH) were considered as secondary outcomes. Results: A total of 101 patients (age: 67 ± 10 years, 38.6% female) were enrolled in our study, including 29 (28.3%) BAO cases, and 72 (71.3%) patients treated with ACS. Patients in the BAO group were slightly older (70 ± 9 years vs. 66 ± 10 years, p = 0.054), and had higher prevalence of comorbidities such as hypertension (100.0% vs. 59.4%, p < 0.001). There was no significant difference in favorable outcomes (51.7% vs. 54.4%, p = 0.808) between the groups. However, we observed a trend towards higher rates of sICH (8.3% vs. 3.4%, p = 0.382) and 90-day mortality (23.5% vs. 13.8%, p = 0.278) with significantly higher frequency of distal embolization (39.1% vs. 17.9%, p = 0.043) in patients with ACS. In the overall population age (p = 0.013), atrial fibrillation (AF) (p = 0.008), National Institutes of Health Stroke Scale (NIHSS) baseline (p = 0.029), and successful recanalization (p = 0.023) were associated with favorable outcome. Conclusion: Endovascular approach of EICA in addition to MT was safe and effective in tandem occlusion of anterior circulation. Furthermore, our results suggest that balloon angioplasty technique without acute stenting shows a comparable favorable outcome rate to ACS with moderately less hemorrhagic events and mortality rates.

Abstract We derive the field-dependent masses in Fermi gauges for arbitrary scalar extensions of the Standard Model. These masses can be used to construct the effective potential for various models of new physics. We release a flexible Mathematica notebook (VefFermi) which performs these calculations and renders large-scale phenomenological studies of various models possible. Motivated by the debate on the importance of gauge dependence, we show that, even in relatively simple models, there exist points where the global minimum is discontinuous in the gauge parameter. Such points require some care in discovering, indicating that a gauge-dependent treatment might still give reasonable results when examining the global features of a model.

The stability of the electroweak vacuum imposes important constraints on new physics models. Such new physics models may introduce one or more new thermal phases with a lower free energy than that of the electroweak vacuum. In this case, the early universe may stay or have already evolved into one of these deeper vacuum states. We investigate this possibility in detail in the singlet extension of the Standard Model, and delineate the corresponding constraints in its parameter space. We also discuss the situation in supersymmetry as another example. To account for the possibility that the universe is trapped in a non-electroweak vacuum, we propose a procedure of calculating the vacuum stability limit efficiently.

Hydroxyapatite (HAp) polymer composites have gained significant attention due to their applications in bone regeneration and tooth implants. This review examines the synthesis, properties, and applications of Hap, highlighting various manufacturing methods, including wet, dry, hydrothermal, and sol–gel processes. The properties of HAp are influenced by precursor materials and are commonly obtained from natural calcium-rich sources like eggshells, seashells, and fish scales. Composite materials, such as cellulose–hydroxyapatite and gelatin–hydroxyapatite, exhibit promising strength and biocompatibility for bone and tissue replacement. Metallic implants and scaffolds enhance stability, including well-known titanium-based and stainless steel-based implants and ceramic body implants. Biopolymers, like chitosan and alginate, combined with Hap, offer chemical stability and strength for tissue engineering. Collagen, fibrin, and gelatin play crucial roles in mimicking natural bone composition. Various synthesis methods like sol–gel, hydrothermal, and solution casting produce HAp crystals, with potential applications in bone repair and regeneration. Additionally, the use of biowaste materials, like eggshells and snails or seashells, not only supports sustainable HAp production but also reduces environmental impact. This review emphasizes the significance of understanding the properties of calcium–phosphate (Ca-P) compounds and processing methods for scaffold generation, highlighting novel characteristics and mechanisms of biomaterials in bone healing. Comparative studies of these methods in specific applications underscore the versatility and potential of HAp composites in biomedical engineering. Overall, HAp composites offer promising solutions for improving patient outcomes in bone replacement and tissue engineering and advancing medical practices.

Abstract Using the GAMBIT global fitting framework, we constrain the MSSM with an eV-scale gravitino as the lightest supersymmetric particle, and the six electroweakinos (neutralinos and charginos) as the only other light new states. We combine 15 ATLAS and 12 CMS searches at 13 TeV, along with a large collection of ATLAS and CMS measurements of Standard Model signatures. This model, which we refer to as the $${{\tilde{G}}}$$ G ~ -EWMSSM, exhibits quite varied collider phenomenology due to its many permitted electroweakino production processes and decay modes. Characteristic $${{\tilde{G}}}$$ G ~ -EWMSSM signal events have two or more Standard Model bosons and missing energy due to the escaping gravitinos. While much of the $${{\tilde{G}}}$$ G ~ -EWMSSM parameter space is excluded, we find several viable parameter regions that predict phenomenologically rich scenarios with multiple neutralinos and charginos within the kinematic reach of the LHC during Run 3, or the High Luminosity LHC. In particular, we identify scenarios with Higgsino-dominated electroweakinos as light as 140 GeV that are consistent with our combined set of collider searches and measurements. The full set of $${{\tilde{G}}}$$ G ~ -EWMSSM parameter samples and GAMBIT input files generated for this work is available via Zenodo.

The aim of this work is to investigate the bonding properties of the ceramic dispersion-strengthened 316L (CDS-316L) composites with the reference 316L stainless steel (REF-316L) using a Gleeble 3800 physical simulator. In previous works, two different composites, REF-316L and 316L, with 1 wt% Al2O3 composite (CDS-316L) have been prepared by spark plasma sintering (SPS). In the present work, these specimens were diffusion-bonded using the following parameters: a temperature range of 950–1000 °C and a uniaxial pressure of 20–30 MPa. It was observed that the deformation of the CDS-316L during the uniaxial bonding process was higher compared to the 316L steel rods. The addition of alumina particles increased the micro-hardness of the 316L steel. The samples were broken in the CDS-316L zones, not at the diffusion-bonded interfaces. No diffusion zones have been observed within the investigated magnification for all composites, where the interfaces between the different specimens were well defined.

Abstract We investigate the extent to which perturbative calculations of the electroweak phase transition are arbitrary and uncertain, owing to their gauge, renormalisation scale and scheme dependence, as well as treatments of the Goldstone catastrophe and daisy diagrams. Using the complete parameter space of the Standard Model extended by a real scalar singlet with a ℤ2 symmetry as a test, we explore the properties of the electroweak phase transition in general R ξ and covariant gauges, OS and MS ¯ $$ \overline{\textrm{MS}} $$ renormalisation schemes, and for common treatments of the Goldstone catastrophe and daisy diagrams. Reassuringly, we find that different renormalisation schemes and different treatments of the Goldstone catastrophe and daisy diagrams typically lead to only modest changes in predictions for the critical temperature and strength of the phase transition. On the other hand, the gauge and renormalisation scale dependence may be significant, and often impact the existence of the phase transition altogether.

A biodegradable amorphous carbonated calcium phosphate (caCP)-incorporated polycaprolactone (PCL) composite layer was successfully deposited by a spin coater. In this specific coating, the PCL acts as a bioadhesive, since it provides a better adherence of the coatings to the substrate compared to powder coatings. The caCP–PCL coatings were deposited and formed thin layers on the surface of a Si3N4–3 wt% MWCNT (multiwalled carbon nanotube) substrate, which is an emerging type of implant material in the biomedical field. The composite coatings were examined regarding their morphology, structure and biological performance. The biocompatibility of the samples was tested in vitro with MC3T3-E1 preosteoblast cells. Owing to the caCP–PCL thin layer, the cell viability values were considerably increased compared to the substrate material. The ALP and LDH tests showed numerous living cells on the investrigated coatings. The morphology of the MC3T3-E1 cells was examined by fluorescent staining (calcein and DAPI) and scanning electron microscopy, both of which revealed a well-spread, adhered and confluent monolayer of cells. All performed biocompatibility tests were positive and indicated the applicability of the deposited thin composite layers as possible candidates for orthopaedic implants for an extended period.

Abstract We introduce the GAMBIT Universal Model Machine (GUM), a tool for automatically generating code for the global fitting software framework GAMBIT, based on Lagrangian-level inputs. GUM accepts models written symbolically in FeynRules and SARAH formats, and can use either tool along with MadGraph and CalcHEP to generate GAMBIT model, collider, dark matter, decay and spectrum code, as well as GAMBIT interfaces to corresponding versions of SPheno, micrOMEGAs, Pythia and Vevacious (C ). In this paper we describe the features, methods, usage, pathways, assumptions and current limitations of GUM. We also give a fully worked example, consisting of the addition of a Majorana fermion simplified dark matter model with a scalar mediator to GAMBIT via GUM, and carry out a corresponding fit.

Abstract We assess the status of a wide class of WIMP dark matter (DM) models in light of the latest experimental results using the global fitting framework GAMBIT. We perform a global analysis of effective field theory (EFT) operators describing the interactions between a gauge-singlet Dirac fermion and the Standard Model quarks, the gluons and the photon. In this bottom-up approach, we simultaneously vary the coefficients of 14 such operators up to dimension 7, along with the DM mass, the scale of new physics and several nuisance parameters. Our likelihood functions include the latest data from Planck, direct and indirect detection experiments, and the LHC. For DM masses below 100 GeV, we find that it is impossible to satisfy all constraints simultaneously while maintaining EFT validity at LHC energies. For new physics scales around 1 TeV, our results are influenced by several small excesses in the LHC data and depend on the prescription that we adopt to ensure EFT validity. Furthermore, we find large regions of viable parameter space where the EFT is valid and the relic density can be reproduced, implying that WIMPs can still account for the DM of the universe while being consistent with the latest data.

Abstract The Fermilab Muon g −2 experiment recently reported its first measurement of the anomalous magnetic moment a μ FNAL $$ {a}_{\mu}^{\mathrm{FNAL}} $$ , which is in full agreement with the previous BNL measurement and pushes the world average deviation ∆ a μ 2021 $$ \Delta {a}_{\mu}^{2021} $$ from the Standard Model to a significance of 4.2σ. Here we provide an extensive survey of its impact on beyond the Standard Model physics. We use state-of-the-art calculations and a sophisticated set of tools to make predictions for a μ , dark matter and LHC searches in a wide range of simple models with up to three new fields, that represent some of the few ways that large ∆a μ can be explained. In addition for the particularly well motivated Minimal Supersymmetric Standard Model, we exhaustively cover the scenarios where large ∆a μ can be explained while simultaneously satisfying all relevant data from other experiments. Generally, the a μ result can only be explained by rather small masses and/or large couplings and enhanced chirality flips, which can lead to conflicts with limits from LHC and dark matter experiments. Our results show that the new measurement excludes a large number of models and provides crucial constraints on others. Two-Higgs doublet and leptoquark models provide viable explanations of a μ only in specific versions and in specific parameter ranges. Among all models with up to three fields, only models with chirality enhancements can accommodate a μ and dark matter simultaneously. The MSSM can simultaneously explain a μ and dark matter for Bino-like LSP in several coannihilation regions. Allowing under abundance of the dark matter relic density, the Higgsino- and particularly Wino-like LSP scenarios become promising explanations of the a μ result.

Bioactive glasses (BGs) are especially useful materials in soft and bone tissue engineering and even in dentistry. They can be the solution to many medical problems, and they have a huge role in the healing processes of bone fractures. Interestingly, they can also promote skin regeneration and wound healing. Bioactive glasses are able to attach to the bone tissues and form an apatite layer which further initiates the biomineralization process. The formed intermediate apatite layer makes a connection between the hard tissue and the bioactive glass material which results in faster healing without any complications or side effects. This review paper summarizes the most recent advancement in the preparation of diverse types of BGs, such as silicate-, borate- and phosphate-based bioactive glasses. We discuss their physical, chemical, and mechanical properties detailing how they affect their biological performances. In order to get a deeper insight into the state-of-the-art in this area, we also consider their medical applications, such as bone regeneration, wound care, and dental/bone implant coatings.