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853 results on '"Cruz-Correa, Marcia"'

1. Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Author

Chen, Zhishan, Guo, Xingyi, Tao, Ran, Huyghe, Jeroen R., Law, Philip J., Fernandez-Rozadilla, Ceres, Ping, Jie, Jia, Guochong, Long, Jirong, Li, Chao, Shen, Quanhu, Xie, Yuhan, Timofeeva, Maria N., Thomas, Minta, Schmit, Stephanie L., Díez-Obrero, Virginia, Devall, Matthew, Moratalla-Navarro, Ferran, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah E. W., Svinti, Victoria, Donnelly, Kevin, Farrington, Susan M., Blackmur, James, Vaughan-Shaw, Peter G., Shu, Xiao-Ou, Lu, Yingchang, Broderick, Peter, Studd, James, Harrison, Tabitha A., Conti, David V., Schumacher, Fredrick R., Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John L., Jenkins, Mark A., Win, Aung Ko, Pai, Rish K., Figueiredo, Jane C., Haile, Robert W., Gallinger, Steven, Woods, Michael O., Newcomb, Polly A., Duggan, David, Cheadle, Jeremy P., Kaplan, Richard, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Jukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri A., Rissanen, Harri, Pukkala, Eero, Eriksson, Johan G., Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie J., Ruiz-Narvaez, Edward, Palmer, Julie R., Buchanan, Daniel D., Platz, Elizabeth A., Visvanathan, Kala, Ulrich, Cornelia M., Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter T., Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha L., Potter, John D., Tsilidis, Kostas K., Schulze, Matthias B., Gunter, Marc J., Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Bishop, D. Timothy, Giles, Graham G., Southey, Melissa C., Idos, Gregory E., McDonnell, Kevin J., Abu-Ful, Zomoroda, Greenson, Joel K., Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope O., van Guelpen, Bethany, Hudson, Thomas J., Hampel, Heather, Pearlman, Rachel, Berndt, Sonja I., Hayes, Richard B., Martinez, Marie Elena, Thomas, Sushma S., Pharoah, Paul D. P., Larsson, Susanna C., Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly F., Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew T., Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David J., Joshi, Amit D., Schafmayer, Clemens, Scacheri, Peter C., Kundaje, Anshul, Schoen, Robert E., Hampe, Jochen, Stadler, Zsofia K., Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Edlund, Christopher K., Gauderman, W. James, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen J., van Duijnhoven, Franzel, Feskens, Edith J. M., Sakoda, Lori C., Gago-Dominguez, Manuela, Wolk, Alicja, Pardini, Barbara, FitzGerald, Liesel M., Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie A., Kooperberg, Charles, Li, Christopher I., Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Le Marchand, Loic, Wu, Anna H., Qu, Chenxu, McNeil, Caroline E., Coetzee, Gerhard, Hayward, Caroline, Deary, Ian J., Harris, Sarah E., Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Lau, Ken S., Zhao, Hongyu, Hsu, Li, Cai, Qiuyin, Dunlop, Malcolm G., Gruber, Stephen B., Houlston, Richard S., Moreno, Victor, Casey, Graham, Peters, Ulrike, Tomlinson, Ian, and Zheng, Wei

Published
2024
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4. Cancer health disparities in racial/ethnic minorities in the United States

Author

Zavala, Valentina A, Bracci, Paige M, Carethers, John M, Carvajal-Carmona, Luis, Coggins, Nicole B, Cruz-Correa, Marcia R, Davis, Melissa, de Smith, Adam J, Dutil, Julie, Figueiredo, Jane C, Fox, Rena, Graves, Kristi D, Gomez, Scarlett Lin, Llera, Andrea, Neuhausen, Susan L, Newman, Lisa, Nguyen, Tung, Palmer, Julie R, Palmer, Nynikka R, Pérez-Stable, Eliseo J, Piawah, Sorbarikor, Rodriquez, Erik J, Sanabria-Salas, María Carolina, Schmit, Stephanie L, Serrano-Gomez, Silvia J, Stern, Mariana C, Weitzel, Jeffrey, Yang, Jun J, Zabaleta, Jovanny, Ziv, Elad, and Fejerman, Laura

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Women's Health, American Indian or Alaska Native, Minority Health, Cancer, Digestive Diseases, Social Determinants of Health, Behavioral and Social Science, Health Disparities, Lung, 2.1 Biological and endogenous factors, Good Health and Well Being, Ethnicity, Female, Health Status Disparities, Humans, Male, Minority Groups, Neoplasms, United States, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

There are well-established disparities in cancer incidence and outcomes by race/ethnicity that result from the interplay between structural, socioeconomic, socio-environmental, behavioural and biological factors. However, large research studies designed to investigate factors contributing to cancer aetiology and progression have mainly focused on populations of European origin. The limitations in clinicopathological and genetic data, as well as the reduced availability of biospecimens from diverse populations, contribute to the knowledge gap and have the potential to widen cancer health disparities. In this review, we summarise reported disparities and associated factors in the United States of America (USA) for the most common cancers (breast, prostate, lung and colon), and for a subset of other cancers that highlight the complexity of disparities (gastric, liver, pancreas and leukaemia). We focus on populations commonly identified and referred to as racial/ethnic minorities in the USA-African Americans/Blacks, American Indians and Alaska Natives, Asians, Native Hawaiians/other Pacific Islanders and Hispanics/Latinos. We conclude that even though substantial progress has been made in understanding the factors underlying cancer health disparities, marked inequities persist. Additional efforts are needed to include participants from diverse populations in the research of cancer aetiology, biology and treatment. Furthermore, to eliminate cancer health disparities, it will be necessary to facilitate access to, and utilisation of, health services to all individuals, and to address structural inequities, including racism, that disproportionally affect racial/ethnic minorities in the USA.

Published
2021

5. Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Author

Fernandez-Rozadilla, Ceres, Timofeeva, Maria, Chen, Zhishan, Law, Philip, Thomas, Minta, Schmit, Stephanie, Díez-Obrero, Virginia, Hsu, Li, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah, Svinti, Victoria, Donnelly, Kevin, Farrington, Susan, Blackmur, James, Vaughan-Shaw, Peter, Shu, Xiao-ou, Long, Jirong, Cai, Qiuyin, Guo, Xingyi, Lu, Yingchang, Broderick, Peter, Studd, James, Huyghe, Jeroen, Harrison, Tabitha, Conti, David, Dampier, Christopher, Devall, Mathew, Schumacher, Fredrick, Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Moratalla-Navarro, Ferran, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John, Jenkins, Mark, Win, Aung Ko, Pai, Rish, Figueiredo, Jane, Haile, Robert, Gallinger, Steven, Woods, Michael, Newcomb, Polly, Duggan, David, Cheadle, Jeremy, Kaplan, Richard, Maughan, Timothy, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Lukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri, Rissanen, Harri, Pukkala, Eero, Eriksson, Johan, Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Zanke, Brent, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie, Ruiz-Narvaez, Edward, Palmer, Julie, Buchanan, Daniel, Platz, Elizabeth, Visvanathan, Kala, Ulrich, Cornelia, Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha, Potter, John, Tsilidis, Konstantinos, Schulze, Matthias, Gunter, Marc, Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Stern, Mariana, Pardamean, Bens, Bishop, Timothy, Giles, Graham, Southey, Melissa, Idos, Gregory, McDonnell, Kevin, Abu-Ful, Zomoroda, Greenson, Joel, Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope, van Guelpen, Bethany, Hudson, Thomas, Hampel, Heather, Pearlman, Rachel, Berndt, Sonja, Hayes, Richard, Martinez, Marie Elena, Thomas, Sushma, Corley, Douglas, Pharoah, Paul, Larsson, Susanna, Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly, Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew, Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David, Joshi, Amit, Schafmayer, Clemens, Scacheri, Peter, Kundaje, Anshul, Nickerson, Deborah, Schoen, Robert, Hampe, Jochen, Stadler, Zsofia, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Papadopoulos, Nickolas, Edlund, Chistopher, Gauderman, William, Thomas, Duncan, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen, van Duijnhoven, Franzel, Feskens, Edith, Sakoda, Lori, Gago-Dominguez, Manuela, Wolk, Alicja, Naccarati, Alessio, Pardini, Barbara, FitzGerald, Liesel, Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie, Kooperberg, Charles, Li, Christopher, Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Tangen, Catherine, Mardis, Elaine, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Haiman, Christopher, Le Marchand, Loic, Wu, Anna, Qu, Chenxu, McNeil, Caroline, Coetzee, Gerhard, Hayward, Caroline, Deary, Ian, Harris, Sarah, Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Moreno, Victor, Casey, Graham, Gruber, Stephen, Tomlinson, Ian, Zheng, Wei, Dunlop, Malcolm, Houlston, Richard, and Peters, Ulrike

Published
2023
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9. Development of a methylation-based, tissue-agnostic test for the detection of molecular residual disease by circulating tumor DNA.

Author

Shen, John Paul Y.C., Reiter, Johannes, Babiarz, Joshua, Srinivasan, Preethi, Lu, Fei, Haghshenas, Ehsan, Chen, Tzu-Chun, Liang, Nathan, Joshi, Jayashree, Huang, Hsiao-Yun, Cerna, Liliana, Alexander, Spenser, Gutman, Boris, Kushwaha, Garima, Aushev, Vasily N., Cruz-Correa, Marcia, Rabinowitz, Matthew, Kawli, Trupti, Aleshin, Alexey, and Cohen, Stacey A.

Published
2025
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10. Genomic alterations in circulating tumor DNA (ctDNA) and response to telisotuzumab adizutecan (ABBV-400) treatment in patients (pts) with colorectal cancer (CRC).

Author

Cecchini, Michael, Sharma, Manish R, Kuboki, Yasutoshi, Perets, Ruth, Cohen, Jonathan, Raimbourg, Judith, Nakajima, Takako Eguchi, Cruz-Correa, Marcia, Ghiringhelli, François, Raghav, Kanwal Pratap Singh, Vasilopoulos, Athanasios, Luo, Xizhi, Neagu Aristide, Martha Raluca, Morrison Thiele, Gladys, Hunter, Zoe, Burns, Michael Charles, Roberts-Rapp, Lisa, and Strickler, John H

Published
2025
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11. Amivantamab with or without chemotherapy in right-sided metastatic colorectal cancer: Updated results from OrigAMI-1, an open-label, phase 1b/2 study.

Author

Raghav, Kanwal Pratap Singh, Van Cutsem, Eric, Arnold, Dirk, Oberstein, Paul Eliezer, Lee, Myung Ah, Cruz-Correa, Marcia, Chen, Eric Xueyu, Han, Sae-Won, Malik, Rozita Abdul, Eng, Cathy, Moreno, Victor, Chowdhury, Sanjib, Iwasawa, Ryota, Schnepp, Robert W., Bhattacharya, Rianka, Lorenzini, Patricia A, Baig, Mahadi, Pietrantonio, Filippo, and Hecht, Joel R

Published
2025
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13. Diagnostic Accuracy of a Blood-Based Biomarker Panel for Colorectal Cancer Detection: A Pilot Study †.

Author

Caraballo, Elba V., Centeno-Girona, Hilmaris, Torres-Velásquez, Brenda Carolina, Martir-Ocasio, Madeline M., González-Pons, María, López-Acevedo, Sheila N., and Cruz-Correa, Marcia

Subjects
RESEARCH funding, CARRIER proteins, RECEIVER operating characteristic curves, EARLY detection of cancer, PILOT projects, ENZYME-linked immunosorbent assay, COLORECTAL cancer, DNA, CASE-control method, BIOMARKERS, CONNECTIVE tissue growth factor, SENSITIVITY & specificity (Statistics)
Abstract

Simple Summary: This study investigates four blood-based biomarkers, mSEPT9, IGFBP2, DKK3, and PKM2, for colorectal cancer (CRC) detection. Current CRC screening methods are often invasive, leading to low compliance. We evaluated the diagnostic accuracy of these plasma biomarkers individually and their combinations in 124 CRC patients and 124 healthy controls. Our results showed that the combination of plasma biomarkers improved accuracy; the combined model outperformed individual biomarkers in detecting CRC. These findings suggest that a multi-biomarker blood test could offer a less invasive, effective alternative for CRC detection, potentially improving early detection rates and patient adherence to screening guidelines. Further research is needed to validate these findings in larger, diverse populations and explore their integration into routine clinical practice. Background: Colorectal cancer (CRC) is a leading cause of death worldwide. Despite its preventability through screening, compliance still needs to improve due to the invasiveness of current tools. There is a growing demand for validated molecular biomarker panels for minimally invasive blood-based CRC screening. This study assessed the diagnostic accuracy of four promising blood-based CRC biomarkers, individually and in combination. Methods: This case–control study involved plasma samples from 124 CRC cases and 124 age- and sex-matched controls. Biomarkers tested included methylated DNA encoding the Septin-9 gene (mSEPT9) using Epi proColon® 2.0 CE, insulin-like growth factor binding protein 2 (IGFBP2), dickkopf-3 (DKK3), and pyruvate kinase M2 (PKM2) by ELISA. Diagnostic accuracy was measured using the receiver operating characteristic (ROC), area under the curve (AUC), as well as sensitivity and specificity. Results: Diagnostic accuracy for mSEPT9, IGFBP2, DKK3, and PKM2 was 62.9% (95% CI: 56.8–62.9%), 69.7% (95% CI: 63.1–69.7%), 61.6% (95% CI: 54.6–61.6%), and 50.8% (95% CI: 43.4–50.8%), respectively. The combined biomarkers yielded an AUC of 74.4% (95% CI: 68.1–80.6%), outperforming all biomarkers except IGFBP2. Conclusions: These biomarkers show potential for developing a minimally invasive CRC detection tool as an alternative to existing approaches, potentially increasing adherence, early detection, and survivorship. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

Author

Schmit, Stephanie L, Edlund, Christopher K, Schumacher, Fredrick R, Gong, Jian, Harrison, Tabitha A, Huyghe, Jeroen R, Qu, Chenxu, Melas, Marilena, Van Den Berg, David J, Wang, Hansong, Tring, Stephanie, Plummer, Sarah J, Albanes, Demetrius, Alonso, M Henar, Amos, Christopher I, Anton, Kristen, Aragaki, Aaron K, Arndt, Volker, Barry, Elizabeth L, Berndt, Sonja I, Bezieau, Stéphane, Bien, Stephanie, Bloomer, Amanda, Boehm, Juergen, Boutron-Ruault, Marie-Christine, Brenner, Hermann, Brezina, Stefanie, Buchanan, Daniel D, Butterbach, Katja, Caan, Bette J, Campbell, Peter T, Carlson, Christopher S, Castelao, Jose E, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Cheng, Iona, Cheng, Ya-Wen, Chin, Lee Soo, Church, James M, Church, Timothy, Coetzee, Gerhard A, Cotterchio, Michelle, Cruz Correa, Marcia, Curtis, Keith R, Duggan, David, Easton, Douglas F, English, Dallas, Feskens, Edith JM, Fischer, Rocky, FitzGerald, Liesel M, Fortini, Barbara K, Fritsche, Lars G, Fuchs, Charles S, Gago-Dominguez, Manuela, Gala, Manish, Gallinger, Steven J, Gauderman, W James, Giles, Graham G, Giovannucci, Edward L, Gogarten, Stephanie M, Gonzalez-Villalpando, Clicerio, Gonzalez-Villalpando, Elena M, Grady, William M, Greenson, Joel K, Gsur, Andrea, Gunter, Marc, Haiman, Christopher A, Hampe, Jochen, Harlid, Sophia, Harju, John F, Hayes, Richard B, Hofer, Philipp, Hoffmeister, Michael, Hopper, John L, Huang, Shu-Chen, Huerta, Jose Maria, Hudson, Thomas J, Hunter, David J, Idos, Gregory E, Iwasaki, Motoki, Jackson, Rebecca D, Jacobs, Eric J, Jee, Sun Ha, Jenkins, Mark A, Jia, Wei-Hua, Jiao, Shuo, Joshi, Amit D, Kolonel, Laurence N, Kono, Suminori, Kooperberg, Charles, Krogh, Vittorio, Kuehn, Tilman, Küry, Sébastien, LaCroix, Andrea, Laurie, Cecelia A, Lejbkowicz, Flavio, Lemire, Mathieu, Lenz, Heinz-Josef, and Levine, David

Subjects
Humans, Colorectal Neoplasms, Genetic Predisposition to Disease, Prognosis, Case-Control Studies, Follow-Up Studies, Genotype, Polymorphism, Single Nucleotide, Ethnic Groups, United States, Genome-Wide Association Study, Genetic Loci, Polymorphism, Single Nucleotide, Oncology And Carcinogenesis, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

BackgroundPrevious genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk.MethodsWe conducted a GWAS in European descent CRC cases and control subjects using a discovery-replication design, followed by examination of novel findings in a multiethnic sample (cumulative n = 163 315). In the discovery stage (36 948 case subjects/30 864 control subjects), we identified genetic variants with a minor allele frequency of 1% or greater associated with risk of CRC using logistic regression followed by a fixed-effects inverse variance weighted meta-analysis. All novel independent variants reaching genome-wide statistical significance (two-sided P < 5 × 10-8) were tested for replication in separate European ancestry samples (12 952 case subjects/48 383 control subjects). Next, we examined the generalizability of discovered variants in East Asians, African Americans, and Hispanics (12 085 case subjects/22 083 control subjects). Finally, we examined the contributions of novel risk variants to familial relative risk and examined the prediction capabilities of a polygenic risk score. All statistical tests were two-sided.ResultsThe discovery GWAS identified 11 variants associated with CRC at P < 5 × 10-8, of which nine (at 4q22.2/5p15.33/5p13.1/6p21.31/6p12.1/10q11.23/12q24.21/16q24.1/20q13.13) independently replicated at a P value of less than .05. Multiethnic follow-up supported the generalizability of discovery findings. These results demonstrated a 14.7% increase in familial relative risk explained by common risk alleles from 10.3% (95% confidence interval [CI] = 7.9% to 13.7%; known variants) to 11.9% (95% CI = 9.2% to 15.5%; known and novel variants). A polygenic risk score identified 4.3% of the population at an odds ratio for developing CRC of at least 2.0.ConclusionsThis study provides insight into the architecture of common genetic variation contributing to CRC etiology and improves risk prediction for individualized screening.

Published
2019

15. The Research Centers in Minority Institutions (RCMI) Translational Research Network: Building and Sustaining Capacity for Multi-Site Basic Biomedical, Clinical and Behavioral Research.

Author

Ofili, Elizabeth O, Tchounwou, Paul B, Fernandez-Repollet, Emma, Yanagihara, Richard, Akintobi, Tabia H, Lee, Jae E, Malouhi, Mohamad, Garner, Solomon T, Hayes, Traci T, Baker, Almelida R, Dent, Andrew L, Abdelrahim, Muna, Rollins, Latrice, Chang, Sandra P, Sy, Angela, Hernandez, Brenda Y, Bullard, Pamela L, Noel, Richard J, Shiramizu, Bruce, Hedges, Jerris R, Berry, Marla J, Bond, Vincent C, Lima, Maria F, Mokuau, Noreen, Kirken, Robert A, Cruz-Correa, Marcia, Sarpong, Daniel F, Vadgama, Jaydutt, Yates, Clayton, Kahn, Shafiq A, Soliman, Karam F, Perry, George, Pezzano, Mark, Luciano, Carlos A, Barnett, M Edwina, Oyekan, Adebayo, Kumar, Deepak, and Norris, Keith C

Subjects
Health Services and Systems, Health Sciences, Health Disparities, Social Determinants of Health, Minority Health, Rural Health, Behavioral and Social Science, American Indian or Alaska Native, Clinical Research, Good Health and Well Being, Behavioral Research, Biomedical Research, Cultural Diversity, Ethnicity, Health Status Disparities, Humans, Minority Groups, Research Personnel, Research Support as Topic, Translational Research, Biomedical, United States, Workforce, Minority-serving Institutions, Underrepresented, Health Inequities, Workforce Diversity, RCMI Investigators and RTRN Team Members, Public Health and Health Services, Public Health, Epidemiology, Public health
Abstract

The Research Centers in Minority Institutions (RCMI) program was established by the US Congress to support the development of biomedical research infrastructure at minority-serving institutions granting doctoral degrees in the health professions or in a health-related science. RCMI institutions also conduct research on diseases that disproportionately affect racial and ethnic minorities (ie, African Americans/Blacks, American Indians and Alaska Natives, Hispanics, Native Hawaiians and Other Pacific Islanders), those of low socioeconomic status, and rural persons. Quantitative metrics, including the numbers of doctoral science degrees granted to underrepresented students, NIH peer-reviewed research funding, peer-reviewed publications, and numbers of racial and ethnic minorities participating in sponsored research, demonstrate that RCMI grantee institutions have made substantial progress toward the intent of the Congressional legislation, as well as the NIH/NIMHD-linked goals of addressing workforce diversity and health disparities. Despite this progress, nationally, many challenges remain, including persistent disparities in research and career development awards to minority investigators. The continuing underrepresentation of minority investigators in NIH-sponsored research across multiple disease areas is of concern, in the face of unrelenting national health inequities. With the collaborative network support by the RCMI Translational Research Network (RTRN), the RCMI community is uniquely positioned to address these challenges through its community engagement and strategic partnerships with non-RCMI institutions. Funding agencies can play an important role by incentivizing such collaborations, and incorporating metrics for research funding that address underrepresented populations, workforce diversity and health equity.

Published
2019

16. Supplementary Table S2 from Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer

Author

Yaeger, Rona, primary, Uboha, Nataliya V., primary, Pelster, Meredith S., primary, Bekaii-Saab, Tanios S., primary, Barve, Minal, primary, Saltzman, Joel, primary, Sabari, Joshua K., primary, Peguero, Julio A., primary, Paulson, Andrew Scott, primary, Jänne, Pasi A., primary, Cruz-Correa, Marcia, primary, Anderes, Kenna, primary, Velastegui, Karen, primary, Yan, Xiaohong, primary, Der-Torossian, Hirak, primary, Klempner, Samuel J., primary, and Kopetz, Scott E., primary

Published
2024
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17. Supplementary Figure S1 from Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer

Author

Yaeger, Rona, primary, Uboha, Nataliya V., primary, Pelster, Meredith S., primary, Bekaii-Saab, Tanios S., primary, Barve, Minal, primary, Saltzman, Joel, primary, Sabari, Joshua K., primary, Peguero, Julio A., primary, Paulson, Andrew Scott, primary, Jänne, Pasi A., primary, Cruz-Correa, Marcia, primary, Anderes, Kenna, primary, Velastegui, Karen, primary, Yan, Xiaohong, primary, Der-Torossian, Hirak, primary, Klempner, Samuel J., primary, and Kopetz, Scott E., primary

Published
2024
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18. Supplementary Appendix from Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer

Author

Yaeger, Rona, primary, Uboha, Nataliya V., primary, Pelster, Meredith S., primary, Bekaii-Saab, Tanios S., primary, Barve, Minal, primary, Saltzman, Joel, primary, Sabari, Joshua K., primary, Peguero, Julio A., primary, Paulson, Andrew Scott, primary, Jänne, Pasi A., primary, Cruz-Correa, Marcia, primary, Anderes, Kenna, primary, Velastegui, Karen, primary, Yan, Xiaohong, primary, Der-Torossian, Hirak, primary, Klempner, Samuel J., primary, and Kopetz, Scott E., primary

Published
2024
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19. Data from Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer

Author

Yaeger, Rona, primary, Uboha, Nataliya V., primary, Pelster, Meredith S., primary, Bekaii-Saab, Tanios S., primary, Barve, Minal, primary, Saltzman, Joel, primary, Sabari, Joshua K., primary, Peguero, Julio A., primary, Paulson, Andrew Scott, primary, Jänne, Pasi A., primary, Cruz-Correa, Marcia, primary, Anderes, Kenna, primary, Velastegui, Karen, primary, Yan, Xiaohong, primary, Der-Torossian, Hirak, primary, Klempner, Samuel J., primary, and Kopetz, Scott E., primary

Published
2024
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20. First-in-human study of ABBV-400, a novel c-Met–targeting antibody-drug conjugate, in advanced solid tumors: Results in colorectal cancer.

Author

Sharma, Manish, primary, Strickler, John H, additional, Sommerhalder, David, additional, Kuboki, Yasutoshi, additional, Perets, Ruth, additional, Cohen, Jonathan, additional, Raimbourg, Judith, additional, Nakajima, Takako Eguchi, additional, Yamamoto, Noboru, additional, Cruz-Correa, Marcia, additional, O'Neil, Bert, additional, Ghiringhelli, François, additional, Raghav, Kanwal Pratap Singh, additional, Li, Rui, additional, Morrison Thiele, Gladys, additional, Neagu Aristide, Martha Raluca, additional, Freise, Kevin Jay, additional, Biesdorf de Almeida, Carla, additional, Vasilopoulos, Athanasios, additional, and Powderly, John D., additional

Published
2024
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22. Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Author

Fernandez-Rozadilla, Ceres, Timofeeva, Maria, Chen, Zhishan, Law, Philip, Thomas, Minta, Schmit, Stephanie, Díez-Obrero, Virginia, Hsu, Li, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah, Svinti, Victoria, Donnelly, Kevin, Farrington, Susan, Blackmur, James, Vaughan-Shaw, Peter, Shu, Xiao-ou, Long, Jirong, Cai, Qiuyin, Guo, Xingyi, Lu, Yingchang, Broderick, Peter, Studd, James, Huyghe, Jeroen, Harrison, Tabitha, Conti, David, Dampier, Christopher, Devall, Mathew, Schumacher, Fredrick, Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Moratalla-Navarro, Ferran, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John, Jenkins, Mark, Win, Aung Ko, Pai, Rish, Figueiredo, Jane, Haile, Robert, Gallinger, Steven, Woods, Michael, Newcomb, Polly, Duggan, David, Cheadle, Jeremy, Kaplan, Richard, Maughan, Timothy, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Lukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri, Rissanen, Harri, Pukkala, Eero, Eriksson, Johan, Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Zanke, Brent, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie, Ruiz-Narvaez, Edward, Palmer, Julie, Buchanan, Daniel, Platz, Elizabeth, Visvanathan, Kala, Ulrich, Cornelia, Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha, Potter, John, Tsilidis, Konstantinos, Schulze, Matthias, Gunter, Marc, Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Stern, Mariana, Pardamean, Bens, Bishop, Timothy, Giles, Graham, Southey, Melissa, Idos, Gregory, McDonnell, Kevin, Abu-Ful, Zomoroda, Greenson, Joel, Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope, van Guelpen, Bethany, Hudson, Thomas, Hampel, Heather, Pearlman, Rachel, Berndt, Sonja, Hayes, Richard, Martinez, Marie Elena, Thomas, Sushma, Corley, Douglas, Pharoah, Paul, Larsson, Susanna, Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly, Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew, Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David, Joshi, Amit, Schafmayer, Clemens, Scacheri, Peter, Kundaje, Anshul, Nickerson, Deborah, Schoen, Robert, Hampe, Jochen, Stadler, Zsofia, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Papadopoulos, Nickolas, Edlund, Chistopher, Gauderman, William, Thomas, Duncan, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen, van Duijnhoven, Franzel, Feskens, Edith, Sakoda, Lori, Gago-Dominguez, Manuela, Wolk, Alicja, Naccarati, Alessio, Pardini, Barbara, FitzGerald, Liesel, Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie, Kooperberg, Charles, Li, Christopher, Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Tangen, Catherine, Mardis, Elaine, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Haiman, Christopher, Le Marchand, Loic, Wu, Anna, Qu, Chenxu, McNeil, Caroline, Coetzee, Gerhard, Hayward, Caroline, Deary, Ian, Harris, Sarah, Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Moreno, Victor, Casey, Graham, Gruber, Stephen, Tomlinson, Ian, Zheng, Wei, Dunlop, Malcolm, Houlston, Richard, and Peters, Ulrike

Published
2023
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23. Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study

Author

Win, Aung Ko, Dowty, James G., Reece, Jeanette C., Lee, Grant, Templeton, Allyson S., Plazzer, John-Paul, Buchanan, Daniel D., Akagi, Kiwamu, Aksoy, Seçil, Alonso, Angel, Alvarez, Karin, Amor, David J., Ankathil, Ravindran, Aretz, Stefan, Arnold, Julie L., Aronson, Melyssa, Austin, Rachel, Backman, Ann-Sofie, Bajwa-ten Broeke, Sanne W., Barca-Tierno, Verónica, Barwell, Julian, Bernstein, Inge, Berthet, Pascaline, Betz, Beate, Bignon, Yves-Jean, Boisjoli, Talya, Bonadona, Valérie, Briollais, Laurent, Brunet, Joan, Bucksch, Karolin, Buecher, Bruno, Buettner, Reinhard, Burn, John, Caldés, Trinidad, Capella, Gabriel, Caron, Olivier, Casey, Graham, Chew, Min H., Choi, Yun-hee, Church, James, Clendenning, Mark, Colas, Chrystelle, Cops, Elisa J., Coupier, Isabelle, Cruz-Correa, Marcia, de la Chapelle, Albert, de Wind, Niels, Dębniak, Tadeusz, Della Valle, Adriana, Delnatte, Capuccine, Dhooge, Marion, Dominguez-Valentin, Mev, Drouet, Youenn, Duijkers, Floor A., Engel, Christoph, Esperon, Patricia, Evans, D. Gareth, Falcón de Vargas, Aída, Figueiredo, Jane C, Foulkes, William, Fourme, Emmanuelle, Frebourg, Thierry, Gallinger, Steven, Garre, Pilar, Genuardi, Maurizio, Gerdes, Anne-Marie, Gima, Lauren M., Giraud, Sophie, Goodwin, Annabel, Görgens, Heike, Green, Kate, Guillem, Jose, Guillén-Ponce, Carmen, Guimbaud, Roselyne, Guindalini, Rodrigo S.C., Half, Elizabeth E., Hall, Michael J, Hampel, Heather, Hansen, Thomas V.O., Heinimann, Karl, Hes, Frederik J., Hill, James, Ho, Judy W.C., Holinski-Feder, Elke, Hoogerbrugge, Nicoline, Hüneburg, Robert, Huntley, Vanessa, James, Paul A., Jensen, Uffe B, John, Thomas, Juhari, Wan K.W., Kalady, Matthew, Kastrinos, Fay, Kloor, Matthias, Kohonen-Corish, Maija RJ, Krogh, Lotte N., Kupfer, Sonia S., Ladabaum, Uri, Lagerstedt-Robinson, Kristina, Lalloo, Fiona, Lasset, Christine, Latchford, Andrew, Laurent-Puig, Pierre, Lautrup, Charlotte K., Leggett, Barbara A., Lejeune, Sophie, LeMarchand, Loic, Ligtenberg, Marjolijn, Lindor, Noralane, Loeffler, Markus, Longy, Michel, Lopez, Francisco, Lowery, Jan, Lubiński, Jan, Lucassen, Anneke M, Lynch, Patrick M., Malińska, Karolina, Matsubara, Nagahide, Mecklin, Jukka-Pekka, Møller, Pål, Monahan, Kevin, Morrison, Patrick J., Nattermann, Jacob, Navarro, Matilde, Neffa, Florencia, Neklason, Deborah, Newcomb, Polly A., Ngeow, Joanne, Nichols, Cassandra, Nielsen, Maartje, Nixon, Dawn M., Nogues, Catherine, Okkels, Henrik, Olschwang, Sylviane, Pachter, Nicholas, Pai, Rish K., Palmero, Edenir I., Pande, Mala, Parry, Susan, Patel, Swati G., Pearlman, Rachel, Perne, Claudia, Pineda, Marta, Poplawski, Nicola K, Pylvänäinen, Kirsi, Qiu, Jay, Rahner, Nils, Ramesar, Raj, Rasmussen, Lene J., Redler, Silke, Reis, Rui M., Ricciardiello, Luigi, Rogoża-Janiszewska, Emilia, Rosty, Christophe, Samadder, N. Jewel, Sampson, Julian R., Schackert, Hans K., Schmiegel, Wolff, Schulmann, Karsten, Schuster, Helène, Scott, Rodney, Senter, Leigha, Seppälä, Toni T, Shtoyerman, Rakefet, Sijmons, Rolf H., Snyder, Carrie, Solomon, Ilana B., Soto, Jose Luis, Southey, Melissa C., Spigelman, Allan, Spirandelli, Florencia, Spurdle, Amanda B., Steinke-Lange, Verena, Stoffel, Elena M., Strassburg, Christian P., Sunde, Lone, Susman, Rachel, Syngal, Sapna, Tanakaya, Kohji, Tezcan, Gülçin, Therkildsen, Christina, Thibodeau, Steve, Tomita, Naohiro, Tucker, Katherine M., Tunca, Berrin, Turchetti, Daniela, Uhrhammer, Nancy, Utsunomiya, Joji, Vaccaro, Carlos, van Duijnhoven, Fränzel J.B., van Wanzeele, Meghan J., Vangala, Deepak B., Vasen, Hans F.A., von Knebel Doeberitz, Magnus, von Salomé, Jenny, Wadt, Karin A.W., Ward, Robyn L., Weitz, Jürgen, Weitzel, Jeffrey N., Williams, Heinric, Winship, Ingrid, Wise, Paul E., Wods, Julie, Woods, Michael O., Yamaguchi, Tatsuro, Zachariae, Silke, Zahary, Mohd N., Hopper, John L., Haile, Robert W., Macrae, Finlay A., Möslein, Gabriela, and Jenkins, Mark A.

Published
2021
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25. Supplementary Figure S2 from Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma

Author

Schoen, Robert E., primary, Boardman, Lisa A., primary, Cruz-Correa, Marcia, primary, Bansal, Ajay, primary, Kastenberg, David, primary, Hur, Chin, primary, Dzubinski, Lynda, primary, Kaufman, Sharon F., primary, Rodriguez, Luz M., primary, Richmond, Ellen, primary, Umar, Asad, primary, Szabo, Eva, primary, Salazar, Andres, primary, McKolanis, John, primary, Beatty, Pamela, primary, Pai, Reetesh K., primary, Singhi, Aatur D., primary, Jacqueline, Camille M., primary, Bao, Riyue, primary, Diergaarde, Brenda, primary, McMurray, Ryan P., primary, Strand, Carrie, primary, Foster, Nathan R., primary, Zahrieh, David M., primary, Limburg, Paul J., primary, and Finn, Olivera J., primary

Published
2024
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26. Supplementary Table S2 from Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma

Author

Schoen, Robert E., primary, Boardman, Lisa A., primary, Cruz-Correa, Marcia, primary, Bansal, Ajay, primary, Kastenberg, David, primary, Hur, Chin, primary, Dzubinski, Lynda, primary, Kaufman, Sharon F., primary, Rodriguez, Luz M., primary, Richmond, Ellen, primary, Umar, Asad, primary, Szabo, Eva, primary, Salazar, Andres, primary, McKolanis, John, primary, Beatty, Pamela, primary, Pai, Reetesh K., primary, Singhi, Aatur D., primary, Jacqueline, Camille M., primary, Bao, Riyue, primary, Diergaarde, Brenda, primary, McMurray, Ryan P., primary, Strand, Carrie, primary, Foster, Nathan R., primary, Zahrieh, David M., primary, Limburg, Paul J., primary, and Finn, Olivera J., primary

Published
2024
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27. Supplementary Methods S2 from Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma

Author

Schoen, Robert E., primary, Boardman, Lisa A., primary, Cruz-Correa, Marcia, primary, Bansal, Ajay, primary, Kastenberg, David, primary, Hur, Chin, primary, Dzubinski, Lynda, primary, Kaufman, Sharon F., primary, Rodriguez, Luz M., primary, Richmond, Ellen, primary, Umar, Asad, primary, Szabo, Eva, primary, Salazar, Andres, primary, McKolanis, John, primary, Beatty, Pamela, primary, Pai, Reetesh K., primary, Singhi, Aatur D., primary, Jacqueline, Camille M., primary, Bao, Riyue, primary, Diergaarde, Brenda, primary, McMurray, Ryan P., primary, Strand, Carrie, primary, Foster, Nathan R., primary, Zahrieh, David M., primary, Limburg, Paul J., primary, and Finn, Olivera J., primary

Published
2024
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28. Variability in Cancer Risk and Outcomes Within US Latinos by National Origin and Genetic Ancestry

Author

Stern, Mariana C, Fejerman, Laura, Das, Rina, Setiawan, V Wendy, Cruz-Correa, Marcia R, Perez-Stable, Eliseo J, and Figueiredo, Jane C

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Oncology and Carcinogenesis, Cancer, Prevention, Urologic Diseases, Lung, Women's Health, Social Determinants of Health, Colo-Rectal Cancer, Digestive Diseases, Rare Diseases, Breast Cancer, Genetics, Good Health and Well Being, Hispanic, Latino
Abstract

Latinos have lower rates for most common cancer sites and higher rates of some less common cancers (gallbladder, liver, gastric, and cervical) than other ethnic/racial groups. Latinos are a highly heterogeneous population with diverse national origins, unique genetic admixture patterns, and wide spectrum of socio-demographic characteristics. Across the major cancers (breast, colorectal, prostate, lung, and liver) US-born Latinos have higher incidence and worse survival than foreign-born, and those with low-socioeconomic status have the lowest incidence. Puerto Rican and Cuban Latinos have higher incidence rates than Mexican Latinos. We have identified the following themes as understudied and critical to reduce the cancer burden among US Latinos: (1) etiological studies considering key sources of heterogeneity, (2) culturally sensitive cancer prevention strategies, (3) description of the molecular tumor landscape to guide treatments and improve outcomes, and (4) development of prediction models of disease risk and outcomes accounting for heterogeneity of Latinos.

Published
2016

29. Fine-mapping analysis including over 254 000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Author

Chen, Zhishan, Guo, Xingyi, Tao, Ran, Huyghe, Jeroen R., Law, Philip J., Fernandez-Rozadilla, Ceres, Ping, Jie, Jia, Guochong, Long, Jirong, Li, Chao, Shen, Quanhu, Xie, Yuhan, Timofeeva, Maria N., Thomas, Minta, Schmit, Stephanie L., Díez-Obrero, Virginia, Devall, Matthew, Moratalla-Navarro, Ferran, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah E. W., Svinti, Victoria, Donnelly, Kevin, Farrington, Susan M., Blackmur, James, Vaughan-Shaw, Peter G., Shu, Xiao-Ou, Lu, Yingchang, Broderick, Peter, Studd, James, Harrison, Tabitha A., Conti, David V., Schumacher, Fredrick R., Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John L., Jenkins, Mark A., Win, Aung Ko, Pai, Rish K., Figueiredo, Jane C., Haile, Robert W., Gallinger, Steven, Woods, Michael O., Newcomb, Polly A., Duggan, David, Cheadle, Jeremy P., Kaplan, Richard, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Jukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri A., Rissanen, Harri, Pukkala, Eero, Eriksson, Johan G., Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie J., Ruiz-Narvaez, Edward, Palmer, Julie R., Buchanan, Daniel D., Platz, Elizabeth A., Visvanathan, Kala, Ulrich, Cornelia M., Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter T., Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha L., Potter, John D., Tsilidis, Kostas K., Schulze, Matthias B., Gunter, Marc J., Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Bishop, D. Timothy, Giles, Graham G., Southey, Melissa C., Idos, Gregory E., McDonnell, Kevin J., Abu-Ful, Zomoroda, Greenson, Joel K., Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope O., van Guelpen, Bethany, Hudson, Thomas J., Hampel, Heather, Pearlman, Rachel, Berndt, Sonja I., Hayes, Richard B., Martinez, Marie Elena, Thomas, Sushma S., Pharoah, Paul D. P., Larsson, Susanna C., Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly F., Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew T., Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David J., Joshi, Amit D., Schafmayer, Clemens, Scacheri, Peter C., Kundaje, Anshul, Schoen, Robert E., Hampe, Jochen, Stadler, Zsofia K., Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Edlund, Christopher K., Gauderman, W. James, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen J., van Duijnhoven, Franzel, Feskens, Edith J. M., Sakoda, Lori C., Gago-Dominguez, Manuela, Wolk, Alicja, Pardini, Barbara, FitzGerald, Liesel M., Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie A., Kooperberg, Charles, Li, Christopher I., Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Le Marchand, Loic, Wu, Anna H., Qu, Chenxu, McNeil, Caroline E., Coetzee, Gerhard, Hayward, Caroline, Deary, Ian J., Harris, Sarah E., Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Lau, Ken S., Zhao, Hongyu, Hsu, Li, Cai, Qiuyin, Dunlop, Malcolm G., Gruber, Stephen B., Houlston, Richard S., Moreno, Victor, Casey, Graham, Peters, Ulrike, Tomlinson, Ian, Zheng, Wei, Chen, Zhishan, Guo, Xingyi, Tao, Ran, Huyghe, Jeroen R., Law, Philip J., Fernandez-Rozadilla, Ceres, Ping, Jie, Jia, Guochong, Long, Jirong, Li, Chao, Shen, Quanhu, Xie, Yuhan, Timofeeva, Maria N., Thomas, Minta, Schmit, Stephanie L., Díez-Obrero, Virginia, Devall, Matthew, Moratalla-Navarro, Ferran, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah E. W., Svinti, Victoria, Donnelly, Kevin, Farrington, Susan M., Blackmur, James, Vaughan-Shaw, Peter G., Shu, Xiao-Ou, Lu, Yingchang, Broderick, Peter, Studd, James, Harrison, Tabitha A., Conti, David V., Schumacher, Fredrick R., Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John L., Jenkins, Mark A., Win, Aung Ko, Pai, Rish K., Figueiredo, Jane C., Haile, Robert W., Gallinger, Steven, Woods, Michael O., Newcomb, Polly A., Duggan, David, Cheadle, Jeremy P., Kaplan, Richard, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Jukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri A., Rissanen, Harri, Pukkala, Eero, Eriksson, Johan G., Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie J., Ruiz-Narvaez, Edward, Palmer, Julie R., Buchanan, Daniel D., Platz, Elizabeth A., Visvanathan, Kala, Ulrich, Cornelia M., Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter T., Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha L., Potter, John D., Tsilidis, Kostas K., Schulze, Matthias B., Gunter, Marc J., Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Bishop, D. Timothy, Giles, Graham G., Southey, Melissa C., Idos, Gregory E., McDonnell, Kevin J., Abu-Ful, Zomoroda, Greenson, Joel K., Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope O., van Guelpen, Bethany, Hudson, Thomas J., Hampel, Heather, Pearlman, Rachel, Berndt, Sonja I., Hayes, Richard B., Martinez, Marie Elena, Thomas, Sushma S., Pharoah, Paul D. P., Larsson, Susanna C., Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly F., Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew T., Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David J., Joshi, Amit D., Schafmayer, Clemens, Scacheri, Peter C., Kundaje, Anshul, Schoen, Robert E., Hampe, Jochen, Stadler, Zsofia K., Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Edlund, Christopher K., Gauderman, W. James, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen J., van Duijnhoven, Franzel, Feskens, Edith J. M., Sakoda, Lori C., Gago-Dominguez, Manuela, Wolk, Alicja, Pardini, Barbara, FitzGerald, Liesel M., Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie A., Kooperberg, Charles, Li, Christopher I., Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Le Marchand, Loic, Wu, Anna H., Qu, Chenxu, McNeil, Caroline E., Coetzee, Gerhard, Hayward, Caroline, Deary, Ian J., Harris, Sarah E., Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Lau, Ken S., Zhao, Hongyu, Hsu, Li, Cai, Qiuyin, Dunlop, Malcolm G., Gruber, Stephen B., Houlston, Richard S., Moreno, Victor, Casey, Graham, Peters, Ulrike, Tomlinson, Ian, and Zheng, Wei

Abstract

Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV. Our cis-eQTL/mQTL and colocalization analyses using colorectal tissue-specific transcriptome and methylome data separately from 1299 and 321 individuals, along with functional genomic investigation, uncovered 136 putative CRC susceptibility genes, including 56 genes not previously reported. Analyses of single-cell RNA-seq data from colorectal tissues revealed 17 putative CRC susceptibility genes with distinct expression patterns in specific cell types. Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.

Published
2024
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30. Genetic epidemiology of BRCA1- and BRCA2-associated cancer across Latin America

Author

Herzog, Josef S., Chavarri-Guerra, Yanin, Castillo, Danielle, Abugattas, Julio, Villarreal-Garza, Cynthia, Sand, Sharon, Clague-Dehart, Jessica, Alvarez-Gómez, Rosa M., Wegman-Ostrosky, Talia, Mohar, Alejandro, Mora, Pamela, Del Toro-Valero, Azucena, Daneri-Navarro, Adrian, Rodriguez, Yenni, Cruz-Correa, Marcia, Ashton-Prolla, Patricia, Alemar, Bárbara, Mejia, Rosa, Gallardo, Lenny, Shaw, Robin, Yang, Kai, Cervantes, Aleck, Tsang, Kevin, Nehoray, Bita, Barrera Saldana, Hugo, Neuhausen, Susan, and Weitzel, Jeffrey N.

Published
2021
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31. A snapshot of current genetic testing practice in Lynch syndrome: The results of a representative survey of 33 Latin American existing centres/registries

Author

Della Valle, Adriana, Rossi, Benedito Mauro, Palmero, Edenir Inêz, Antelo, Marina, Vaccaro, Carlos Alberto, López-Kostner, Francisco, Alvarez, Karin, Cruz-Correa, Marcia, Bruno, Luisina Inés, Forones, Nora Manoukian, Mindiola, Jorge Andres Rugeles, Buleje, José, Spirandelli, Florencia, Bohorquez, Mabel, Cock-Rada, Alicia Maria, Sullcahuaman, Yasser, Nascimento, Ivana, Abe-Sandes, Kiyoko, Lino-Silva, Leonardo S., Petracchi, Florencia, Mampel, Alejandra, Rodriguez, Yeni, Rossi, Norma Teresa, Yañez, Claudio Benavides, Rubio, Cladelis, Petta-Lajus, Tirzah Braz, Silveira-Lucas, Elizabeth Lemos, Jiménez, Geiner, Peña, Carlos Mario Muñeton, Reyes-Silva, Carlos, Ayala-Madrigal, María de la Luz, del Monte, Julio Sánchez, Quispe, Richard, Recalde, Alcides, Neffa, Florencia, Sarroca, Carlos, de Campos Reis Galvão, Henrique, Golubicki, Mariano, Piñero, Tamara A., Kalfayan, Pablo G., Ferro, Fabiana Alejandra, Gonzalez, Maria Laura, Pérez-Mayoral, Julyann, Pimenta, Celia Aparecida Marques, Uyaban, Sandra Patricia Bello, Protzel, Ana, Chávez, Guiliana, Dueñas, Milagros, Gil, María Luisa Guevara, Spirandelli, Enrique, Chialina, Sergio, Echeverry, Magdalena, Fuenmayor, Luis José Palacios, Torres, Mariela, Palma, Thais F.Bonfim, Héritas, Nadia Cambados, Martin, Claudia, Suárez, Alfonso, Vallejo, Michael, Rafaela de Souza Timoteo, Ana, Ayala, Carlos Afanador, Jaramillo-Koupermann, Gabriela, Hernández-Sandoval, Jesús Arturo, Guerrero, Angélica Hernandez, Dominguez-Barrera, Constantino, Bazo-Alvarez, Juan Carlos, Wernhoff, Patrik, Plazzer, John-Paul, Balavarca, Yesilda, Hovig, Eivind, Møller, Pål, and Dominguez-Valentin, Mev

Published
2019
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32. Tislelizumab plus chemotherapy (chemo) versus placebo plus chemo as first-line treatment for locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma: RATIONALE-305 European/North American patient subgroup.

Author

Arkenau, Hendrik-Tobias, primary, Tabernero, Josep, additional, Cruz-Correa, Marcia, additional, Zimina, Anastasia V., additional, Poddubskaya, Elena, additional, Moiseenko, Fedor Vladimirovich, additional, Spigel, David R., additional, Wyrwicz, Lucjan S., additional, Disel, Umut, additional, Pazo Cid, Roberto, additional, Cubillo Gracian, Antonio, additional, Alés Diaz, Inmaculada, additional, Fornaro, Lorenzo, additional, Evesque, Ludovic, additional, Xu, Yaling, additional, Sheng, Tao, additional, Yang, Silu, additional, Li, Liyun, additional, Moehler, Markus H., additional, and Xu, Rui-Hua, additional

Published
2024
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33. Tislelizumab (TIS) plus chemotherapy (Chemo) vs placebo (PBO) plus chemo as first-line (1L) treatment of advanced gastric or gastroesophageal junction adenocarcinoma (GC/GEJC): Health-related quality of life (HRQoL) outcomes in the RATIONALE-305 study.

Author

Cruz-Correa, Marcia, primary, Xu, Rui-Hua, additional, Moehler, Markus H., additional, Oh, Do-Youn, additional, Kato, Ken, additional, Spigel, David R., additional, Arkenau, Hendrik-Tobias, additional, Tabernero, Josep, additional, Zimina, Anastasia V., additional, Bai, Yuxian, additional, Shi, Jianhua, additional, Lee, Keun-Wook, additional, Hirano, Hidekazu, additional, Wyrwicz, Lucjan S., additional, Pazo Cid, Roberto, additional, Xu, Hui, additional, Sheng, Tao, additional, and Barnes, Gisoo, additional

Published
2024
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38. 1526 Nous-209 genetic vaccine encoding shared cancer neoantigens is safe and elicits robust immune response in healthy Lynch syndrome carriers: interim results from Phase 1 cancer interception trial

Author

D’Alise, Morena, primary, Willis, Jason, additional, Leoni, Guido, additional, Cruz-Correa, Marcia, additional, Hall, Michael J, additional, Idos, Gregory E, additional, Garzia, Irene, additional, Antonucci, Laura, additional, Cotugno, Gabriella, additional, Siani, Loredana, additional, Gogov, Sven, additional, Liu, Diane, additional, Lee, Jack, additional, Vornik, Lana A, additional, Uribe, Laura Reyes, additional, Garcia-Gonzalez, Araceli, additional, Richmond, Ellen, additional, Umar, Asad, additional, Brown, Powel H, additional, Rodriguez, Luz Maria, additional, Scarselli, Elisa, additional, and Vilar, Eduardo, additional

Published
2023
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43. The spectrum of genetic variants in hereditary pancreatic cancer includes Fanconi anemia genes

Author

Slavin, Thomas P., Neuhausen, Susan L., Nehoray, Bita, Niell-Swiller, Mariana, Solomon, Ilana, Rybak, Christina, Blazer, Kathleen, Adamson, Aaron, Yang, Kai, Sand, Sharon, Guerrero-Llamas, Nancy, Castillo, Danielle, Herzog, Josef, Wu, Xiwei, Tao, Shu, Raja, Shivali, Chung, Vincent, Singh, Gagandeep, Nadesan, Sue, Brown, Sandra, Cruz-Correa, Marcia, Petersen, Gloria M., Weitzel, Jeffrey, and Clinical Cancer Genomics Community Research Network (CCGCRN)

Published
2018
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46. Supplementary Table S5 from Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma

Author

Schoen, Robert E., primary, Boardman, Lisa A., primary, Cruz-Correa, Marcia, primary, Bansal, Ajay, primary, Kastenberg, David, primary, Hur, Chin, primary, Dzubinski, Lynda, primary, Kaufman, Sharon F., primary, Rodriguez, Luz M., primary, Richmond, Ellen, primary, Umar, Asad, primary, Szabo, Eva, primary, Salazar, Andres, primary, McKolanis, John, primary, Beatty, Pamela, primary, Pai, Reetesh K., primary, Singhi, Aatur D., primary, Jacqueline, Camille M., primary, Bao, Riyue, primary, Diergaarde, Brenda, primary, McMurray, Ryan P., primary, Strand, Carrie, primary, Foster, Nathan R., primary, Zahrieh, David M., primary, Limburg, Paul J., primary, and Finn, Olivera J., primary

Published
2023
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47. Supplementary Figure S2 from Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma

Author

Schoen, Robert E., primary, Boardman, Lisa A., primary, Cruz-Correa, Marcia, primary, Bansal, Ajay, primary, Kastenberg, David, primary, Hur, Chin, primary, Dzubinski, Lynda, primary, Kaufman, Sharon F., primary, Rodriguez, Luz M., primary, Richmond, Ellen, primary, Umar, Asad, primary, Szabo, Eva, primary, Salazar, Andres, primary, McKolanis, John, primary, Beatty, Pamela, primary, Pai, Reetesh K., primary, Singhi, Aatur D., primary, Jacqueline, Camille M., primary, Bao, Riyue, primary, Diergaarde, Brenda, primary, McMurray, Ryan P., primary, Strand, Carrie, primary, Foster, Nathan R., primary, Zahrieh, David M., primary, Limburg, Paul J., primary, and Finn, Olivera J., primary

Published
2023
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48. Supplementary Methods S1 from Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma

Author

Schoen, Robert E., primary, Boardman, Lisa A., primary, Cruz-Correa, Marcia, primary, Bansal, Ajay, primary, Kastenberg, David, primary, Hur, Chin, primary, Dzubinski, Lynda, primary, Kaufman, Sharon F., primary, Rodriguez, Luz M., primary, Richmond, Ellen, primary, Umar, Asad, primary, Szabo, Eva, primary, Salazar, Andres, primary, McKolanis, John, primary, Beatty, Pamela, primary, Pai, Reetesh K., primary, Singhi, Aatur D., primary, Jacqueline, Camille M., primary, Bao, Riyue, primary, Diergaarde, Brenda, primary, McMurray, Ryan P., primary, Strand, Carrie, primary, Foster, Nathan R., primary, Zahrieh, David M., primary, Limburg, Paul J., primary, and Finn, Olivera J., primary

Published
2023
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49. Data from Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma

Author

Schoen, Robert E., primary, Boardman, Lisa A., primary, Cruz-Correa, Marcia, primary, Bansal, Ajay, primary, Kastenberg, David, primary, Hur, Chin, primary, Dzubinski, Lynda, primary, Kaufman, Sharon F., primary, Rodriguez, Luz M., primary, Richmond, Ellen, primary, Umar, Asad, primary, Szabo, Eva, primary, Salazar, Andres, primary, McKolanis, John, primary, Beatty, Pamela, primary, Pai, Reetesh K., primary, Singhi, Aatur D., primary, Jacqueline, Camille M., primary, Bao, Riyue, primary, Diergaarde, Brenda, primary, McMurray, Ryan P., primary, Strand, Carrie, primary, Foster, Nathan R., primary, Zahrieh, David M., primary, Limburg, Paul J., primary, and Finn, Olivera J., primary

Published
2023
Full Text
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