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1. Substernal lead removal: experience from the EV ICD pivotal study

Author

Amin, A, primary, Crozier, I, additional, Murgatroyd, F, additional, Boersma, L V A, additional, Manlucu, J, additional, Knight, B P, additional, Leclercq, C, additional, Birgersdotter-Green, U M, additional, Chan, J Y S, additional, Roukoz, H, additional, Biffi, M, additional, Sagi, V, additional, Wiggenhorn, C, additional, and Friedman, P, additional

Published
2024
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2. Chronic safety and performance of the extravascular ICD: results from the global EV ICD Pivotal study

Author

Boersma, L, primary, Friedman, P, additional, Murgatroyd, F, additional, Manlucu, J, additional, Knight, B P, additional, Clementy, N, additional, Leclercq, C, additional, Amin, A, additional, Merkely, B P, additional, Birgersdotter-Green, U M, additional, Chan, J Y S, additional, Biffi, M, additional, Knops, R E, additional, Wiggenhorn, C, additional, and Crozier, I, additional

Published
2023
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3. CHRONIC SAFETY AND PERFORMANCE OF THE EXTRAVASCULAR ICD: RESULTS FROM THE GLOBAL EV ICD PIVOTAL STUDY

Author

Manlucu, J., primary, Friedman, P., additional, Murgatroyd, F., additional, Boersma, L., additional, Knight, B., additional, Clementy, N., additional, Leclercq, C., additional, Amin, A., additional, Merkely, B., additional, Birgersdotter-Green, U., additional, Chan, J. Sun, additional, Biffi, M., additional, Knops, R., additional, Wiggenhorn, C., additional, Crozier, I., additional, and Molan, A., additional

Published
2023
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6. 707 Photography and AI in an outbreak-based mpox trial

Author

Saknite, I., McNeil, A.J., Kasereka, S., Tshilombo, J.M., Malamba, E., Tshi-Manina, O., Lodi, F., Tshimanga, C., Baudouin, M., Marcel, A., Djese, R., Diphanga, G., Mutombo, P., Nzengu, G., Mukendi, G., Amani, F., Kitenge, O Kasangi, Ndjekembo, M., Mayaka, J., Lonza, H., Ndjeka, D., Ibemba, S., Lukala, C., Okamba, M., Clementine, N.N., Edwige, M.M., Oleko, J., Takoy, D., Jean-Claude, L.M., Basika, M., Kayembe, G., Dilu, A., Nganga, B., Ali, R., Tshomba, A.O., Silaphet, T., Jiang, B., Millard, M., Cowen, E.W., Crozier, I., Dawant, B.M., Dodd, L.E., Davey, R.T., Jr., Lane, H.C., Muyembe-Tamfum, J.J., Biampata, J.L., Nussenblatt, V., Mbaya, O Tshiani, Mbala-Kingebeni, P., and Tkaczyk, E.R.

Published
2024
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7. Three-year chronic follow-up from the pilot study of a substernal extravascular implantable cardioverter defibrillator

Author

Crozier, I, primary, Haqqani, H, additional, Kotschet, E, additional, Shaw, D, additional, Prabhu, A, additional, Roubos, J, additional, Alison, J, additional, Melton, I, additional, Denman, R, additional, Lin, T, additional, Almeida, A, additional, Thompson, A, additional, Lande, J, additional, Liang, S, additional, and O’donnell, D, additional

Published
2022
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9. Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author

Kuhn J.H., Adkins S., Agwanda B.R., Al Kubrusli R., Alkhovsky S.V., Amarasinghe G.K., Avsic-Zupanc T., Ayllon M.A., Bahl J., Balkema-Buschmann A., Ballinger M.J., Basler C.F., Bavari S., Beer M., Bejerman N., Bennett A.J., Bente D.A., Bergeron E., Bird B.H., Blair C.D., Blasdell K.R., Blystad D.-R., Bojko J., Borth W.B., Bradfute S., Breyta R., Briese T., Brown P.A., Brown J.K., Buchholz U.J., Buchmeier M.J., Bukreyev A., Burt F., Buttner C., Calisher C.H., Cao M., Casas I., Chandran K., Charrel R.N., Cheng Q., Chiaki Y., Chiapello M., Choi I.-R., Ciuffo M., Clegg J.C.S., Crozier I., Dal Bo E., de la Torre J.C., de Lamballerie X., de Swart R.L., Debat H., Dheilly N.M., Di Cicco E., Di Paola N., Di Serio F., Dietzgen R.G., Digiaro M., Dolnik O., Drebot M.A., Drexler J.F., Dundon W.G., Duprex W.P., Durrwald R., Dye J.M., Easton A.J., Ebihara H., Elbeaino T., Ergunay K., Ferguson H.W., Fooks A.R., Forgia M., Formenty P.B.H., Franova J., Freitas-Astua J., Fu J., Furl S., Gago-Zachert S., Gao G.F., Garcia M.L., Garcia-Sastre A., Garrison A.R., Gaskin T., Gonzalez J.-P.J., Griffiths A., Goldberg T.L., Groschup M.H., Gunther S., Hall R.A., Hammond J., Han T., Hepojoki J., Hewson R., Hong J., Hong N., Hongo S., Horie M., Hu J.S., Hu T., Hughes H.R., Huttner F., Hyndman T.H., Ilyas M., Jalkanen R., Jiang D., Jonson G.B., Junglen S., Kadono F., Kaukinen K.H., Kawate M., Klempa B., Klingstrom J., Kobinger G., Koloniuk I., Kondo H., Koonin E.V., Krupovic M., Kubota K., Kurath G., Laenen L., Lambert A.J., Langevin S.L., Lee B., Lefkowitz E.J., Leroy E.M., Li S., Li L., Li J., Liu H., Lukashevich I.S., Maes P., de Souza W.M., Marklewitz M., Marshall S.H., Marzano S.-Y.L., Massart S., McCauley J.W., Melzer M., Mielke-Ehret N., Miller K.M., Ming T.J., Mirazimi A., Mordecai G.J., Muhlbach H.-P., Muhlberger E., Naidu R., Natsuaki T., Navarro J.A., Netesov S.V., Neumann G., Nowotny N., Nunes M.R.T., Olmedo-Velarde A., Palacios G., Pallas V., Palyi B., Papa A., Paraskevopoulou S., Park A.C., Parrish C.R., Patterson D.A., Pauvolid-Correa A., Paweska J.T., Payne S., Peracchio C., Perez D.R., Postler T.S., Qi L., Radoshitzky S.R., Resende R.O., Reyes C.A., Rima B.K., Luna G.R., Romanowski V., Rota P., Rubbenstroth D., Rubino L., Runstadler J.A., Sabanadzovic S., Sall A.A., Salvato M.S., Sang R., Sasaya T., Schulze A.D., Schwemmle M., Shi M., Shi X., Shi Z., Shimomoto Y., Shirako Y., Siddell S.G., Simmonds P., Sironi M., Smagghe G., Smither S., Song J.-W., Spann K., Spengler J.R., Stenglein M.D., Stone D.M., Sugano J., Suttle C.A., Tabata A., Takada A., Takeuchi S., Tchouassi D.P., Teffer A., Tesh R.B., Thornburg N.J., Tomitaka Y., Tomonaga K., Tordo N., Torto B., Towner J.S., Tsuda S., Tu C., Turina M., Tzanetakis I.E., Uchida J., Usugi T., Vaira A.M., Vallino M., van den Hoogen B., Varsani A., Vasilakis N., Verbeek M., von Bargen S., Wada J., Wahl V., Walker P.J., Wang L.-F., Wang G., Wang Y., Waqas M., Wei T., Wen S., Whitfield A.E., Williams J.V., Wolf Y.I., Wu J., Xu L., Yanagisawa H., Yang C., Yang Z., Zerbini F.M., Zhai L., Zhang Y.-Z., Zhang S., Zhang J., Zhang Z., and Zhou X.

Subjects
Virus classification, Negative-stranded RNA viruses
Abstract

In March 2021, following the annual International Committee on Taxonomy of Viruses (ICTV) ratifcation vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by four families (Aliusviridae, Crepuscuviridae, Myriaviridae, and Natareviridae), three subfamilies (Alpharhabdovirinae, Betarhabdovirinae, and Gammarhabdovirinae), 42 genera, and 200 species. Thirty-nine species were renamed and/ or moved and seven species were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV

Published
2021

10. 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author

Kuhn, J.H., Adkins, S., Agwanda, B.R., Al Kubrusli, R., Alkhovsky, S.V., Amarasinghe, G.K., Avšič-Županc, T., Ayllón, M.A., Bahl, J., Balkema-Buschmann, A., Ballinger, M.J., Basler, C.F., Bavari, S., Beer, M., Bejerman, N., Bennett, A.J., Bente, D.A., Bergeron, É., Bird, B.H., Blair, C.D., Blasdell, K.R., Blystad, D-R, Bojko, J., Borth, W.B., Bradfute, S., Breyta, R., Briese, T., Brown, P.A., Brown, J.K., Buchholz, U.J., Buchmeier, M.J., Bukreyev, A., Burt, F., Büttner, C., Calisher, C.H., Cao, M., Casas, I., Chandran, K., Charrel, R.N., Cheng, Q., Chiaki, Y., Chiapello, M., Choi, I-R, Ciuffo, M., Clegg, J.C.S., Crozier, I., Dal Bó, E., de la Torre, J.C., de Lamballerie, X., de Swart, R.L., Debat, H., Dheilly, N.M., Di Cicco, E., Di Paola, N., Di Serio, F., Dietzgen, R.G., Digiaro, M., Dolnik, O., Drebot, M.A., Drexler, J.F., Dundon, W.G., Duprex, W.P., Dürrwald, R., Dye, J.M., Easton, A.J., Ebihara, H., Elbeaino, T., Ergünay, K., Ferguson, H.W., Fooks, A.R., Forgia, M., Formenty, P.B.H., Fránová, J., Freitas-Astúa, J., Fu, J., Fürl, S., Gago-Zachert, S., Gāo, G.F., García, M.L., García-Sastre, A., Garrison, A.R., Gaskin, T., Gonzalez, J-P.J., Griffiths, A., Goldberg, T.L., Groschup, M.H., Günther, S., Hall, R.A., Hammond, J., Han, T., Hepojoki, J., Hewson, R., Hong, J., Hong, N., Hongo, S., Horie, M., Hu, J.S., Hu, T., Hughes, H.R., Hüttner, F., Hyndman, T.H., Ilyas, M., Jalkanen, R., Jiāng, D., Jonson, G.B., Junglen, S., Kadono, F., Kaukinen, K.H., Kawate, M., Klempa, B., Klingström, J., Kobinger, G., Koloniuk, I., Kondo, H., Koonin, E.V., Krupovic, M., Kubota, K., Kurath, G., Laenen, L., Lambert, A.J., Langevin, S.L., Lee, B., Lefkowitz, E.J., Leroy, E.M., Li, S., Li, L., Lǐ, J., Liu, H., Lukashevich, I.S., Maes, P., de Souza, W.M., Marklewitz, M., Marshall, S.H., Marzano, S-Y.L., Massart, S., McCauley, J.W., Melzer, M., Mielke-Ehret, N., Miller, K.M., Ming, T.J., Mirazimi, A., Mordecai, G.J., Mühlbach, H-P, Mühlberger, E., Naidu, R., Natsuaki, T., Navarro, J.A., Netesov, S.V., Neumann, G., Nowotny, N., Nunes, M.R.T., Olmedo-Velarde, A., Palacios, G., Pallas, V., Pályi, B., Papa, A., Paraskevopoulou, S., Park, A.C., Parrish, C.R., Patterson, D.A., Pauvolid-Corrêa, A., Pawęska, J.T., Payne, S., Peracchio, C., Pérez, D.R., Postler, T.S., Qi, L., Radoshitzky, S.R., Resende, R.O., Reyes, C.A., Rima, B.K., Luna, G.R., Romanowski, V., Rota, P., Rubbenstroth, D., Rubino, L., Runstadler, J.A., Sabanadzovic, S., Sall, A.A., Salvato, M.S., Sang, R., Sasaya, T., Schulze, A.D., Schwemmle, M., Shi, M., Shi, X., Shí, Z., Shimomoto, Y., Shirako, Y., Siddell, S.G., Simmonds, P., Sironi, M., Smagghe, G., Smither, S., Song, J-W, Spann, K., Spengler, J.R., Stenglein, M.D., Stone, D.M., Sugano, J., Suttle, C.A., Tabata, A., Takada, A., Takeuchi, S., Tchouassi, D.P., Teffer, A., Tesh, R.B., Thornburg, N.J., Tomitaka, Y., Tomonaga, K., Tordo, N., Torto, B., Towner, J.S., Tsuda, S., Tu, C., Turina, M., Tzanetakis, I.E., Uchida, J., Usugi, T., Vaira, A.M., Vallino, M., van den Hoogen, B., Varsani, A., Vasilakis, N., Verbeek, M., von Bargen, S., Wada, J., Wahl, V., Walker, P.J., Wang, L-F, Wang, G., Wang, Y., Waqas, M., Wèi, T., Wen, S., Whitfield, A.E., Williams, J.V., Wolf, Y.I., Wu, J., Xu, L., Yanagisawa, H., Yang, C., Yang, Z., Zerbini, F.M., Zhai, L., Zhang, Y-Z, Zhang, S., Zhang, J., Zhang, Z., Zhou, X., Kuhn, J.H., Adkins, S., Agwanda, B.R., Al Kubrusli, R., Alkhovsky, S.V., Amarasinghe, G.K., Avšič-Županc, T., Ayllón, M.A., Bahl, J., Balkema-Buschmann, A., Ballinger, M.J., Basler, C.F., Bavari, S., Beer, M., Bejerman, N., Bennett, A.J., Bente, D.A., Bergeron, É., Bird, B.H., Blair, C.D., Blasdell, K.R., Blystad, D-R, Bojko, J., Borth, W.B., Bradfute, S., Breyta, R., Briese, T., Brown, P.A., Brown, J.K., Buchholz, U.J., Buchmeier, M.J., Bukreyev, A., Burt, F., Büttner, C., Calisher, C.H., Cao, M., Casas, I., Chandran, K., Charrel, R.N., Cheng, Q., Chiaki, Y., Chiapello, M., Choi, I-R, Ciuffo, M., Clegg, J.C.S., Crozier, I., Dal Bó, E., de la Torre, J.C., de Lamballerie, X., de Swart, R.L., Debat, H., Dheilly, N.M., Di Cicco, E., Di Paola, N., Di Serio, F., Dietzgen, R.G., Digiaro, M., Dolnik, O., Drebot, M.A., Drexler, J.F., Dundon, W.G., Duprex, W.P., Dürrwald, R., Dye, J.M., Easton, A.J., Ebihara, H., Elbeaino, T., Ergünay, K., Ferguson, H.W., Fooks, A.R., Forgia, M., Formenty, P.B.H., Fránová, J., Freitas-Astúa, J., Fu, J., Fürl, S., Gago-Zachert, S., Gāo, G.F., García, M.L., García-Sastre, A., Garrison, A.R., Gaskin, T., Gonzalez, J-P.J., Griffiths, A., Goldberg, T.L., Groschup, M.H., Günther, S., Hall, R.A., Hammond, J., Han, T., Hepojoki, J., Hewson, R., Hong, J., Hong, N., Hongo, S., Horie, M., Hu, J.S., Hu, T., Hughes, H.R., Hüttner, F., Hyndman, T.H., Ilyas, M., Jalkanen, R., Jiāng, D., Jonson, G.B., Junglen, S., Kadono, F., Kaukinen, K.H., Kawate, M., Klempa, B., Klingström, J., Kobinger, G., Koloniuk, I., Kondo, H., Koonin, E.V., Krupovic, M., Kubota, K., Kurath, G., Laenen, L., Lambert, A.J., Langevin, S.L., Lee, B., Lefkowitz, E.J., Leroy, E.M., Li, S., Li, L., Lǐ, J., Liu, H., Lukashevich, I.S., Maes, P., de Souza, W.M., Marklewitz, M., Marshall, S.H., Marzano, S-Y.L., Massart, S., McCauley, J.W., Melzer, M., Mielke-Ehret, N., Miller, K.M., Ming, T.J., Mirazimi, A., Mordecai, G.J., Mühlbach, H-P, Mühlberger, E., Naidu, R., Natsuaki, T., Navarro, J.A., Netesov, S.V., Neumann, G., Nowotny, N., Nunes, M.R.T., Olmedo-Velarde, A., Palacios, G., Pallas, V., Pályi, B., Papa, A., Paraskevopoulou, S., Park, A.C., Parrish, C.R., Patterson, D.A., Pauvolid-Corrêa, A., Pawęska, J.T., Payne, S., Peracchio, C., Pérez, D.R., Postler, T.S., Qi, L., Radoshitzky, S.R., Resende, R.O., Reyes, C.A., Rima, B.K., Luna, G.R., Romanowski, V., Rota, P., Rubbenstroth, D., Rubino, L., Runstadler, J.A., Sabanadzovic, S., Sall, A.A., Salvato, M.S., Sang, R., Sasaya, T., Schulze, A.D., Schwemmle, M., Shi, M., Shi, X., Shí, Z., Shimomoto, Y., Shirako, Y., Siddell, S.G., Simmonds, P., Sironi, M., Smagghe, G., Smither, S., Song, J-W, Spann, K., Spengler, J.R., Stenglein, M.D., Stone, D.M., Sugano, J., Suttle, C.A., Tabata, A., Takada, A., Takeuchi, S., Tchouassi, D.P., Teffer, A., Tesh, R.B., Thornburg, N.J., Tomitaka, Y., Tomonaga, K., Tordo, N., Torto, B., Towner, J.S., Tsuda, S., Tu, C., Turina, M., Tzanetakis, I.E., Uchida, J., Usugi, T., Vaira, A.M., Vallino, M., van den Hoogen, B., Varsani, A., Vasilakis, N., Verbeek, M., von Bargen, S., Wada, J., Wahl, V., Walker, P.J., Wang, L-F, Wang, G., Wang, Y., Waqas, M., Wèi, T., Wen, S., Whitfield, A.E., Williams, J.V., Wolf, Y.I., Wu, J., Xu, L., Yanagisawa, H., Yang, C., Yang, Z., Zerbini, F.M., Zhai, L., Zhang, Y-Z, Zhang, S., Zhang, J., Zhang, Z., and Zhou, X.

Abstract

In March 2021, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by four families (Aliusviridae, Crepuscuviridae, Myriaviridae, and Natareviridae), three subfamilies (Alpharhabdovirinae, Betarhabdovirinae, and Gammarhabdovirinae), 42 genera, and 200 species. Thirty-nine species were renamed and/or moved and seven species were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.

Published
2021

11. The extravascular implantable cardioverter-defibrillator: characterization of anatomical parameters impacting substernal implantation and defibrillation efficacy.

Author

Molnar L., Crozier I., Haqqani H., O'Donnell D., Kotschet E., Alison J., Thompson A.E., Bhatia V.A., Papp R., Zima E., Jermendy A., Apor A., Merkely B., Molnar L., Crozier I., Haqqani H., O'Donnell D., Kotschet E., Alison J., Thompson A.E., Bhatia V.A., Papp R., Zima E., Jermendy A., Apor A., and Merkely B.

Abstract

AIMS: The aim of this study is to provide a thorough, quantified assessment of the substernal space as the site of extravascular implantable cardioverter-defibrillator (ICD) lead placement using computed tomography (CT) scans and summarizing adverse events and defibrillation efficacy across anatomical findings. Subcutaneous ICDs are an alternative to transvenous defibrillators but have limitations related to ICD lead distance from the heart. An alternative extravascular system with substernal lead placement has the potential to provide defibrillation at lower energy and pacing therapies from a single device. METHODS AND RESULTS: A multi-centre, non-randomized, retrospective analysis of 45 patient CT scans quantitatively and qualitatively assessing bony, cardiac, vascular, and other organ structures from two human clinical studies with substernal lead placement. Univariate logistic regression was used to evaluate 15 anatomical parameters for impact on defibrillation outcome and adjusted for multiple comparisons. Adverse events were summarized. Substernal implantation was attempted or completed in 45 patients. Defibrillation testing was successful in 37 of 41 subjects (90%) using >=10 J safety margin. There were two intra-procedural adverse events in one patient, including reaction to anaesthesia and an episode of transient atrial fibrillation during ventricular fibrillation induction. Anatomical factors associated with defibrillation failure included large rib cage width, myocardium extending very posteriorly, and a low heart position in the chest (P-values <0.05), though not significant adjusting for multiple comparisons. CONCLUSION(S): Retrospective analysis demonstrates the ability to implant within the substernal space with low intra-procedural adverse events and high defibrillation efficacy despite a wide range of anatomical variability.Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.

Published
2021

12. Design and Preliminary Results of Sensing and Detection for an Extravascular Implantable Cardioverter-Defibrillator.

Author

Crozier I., Liu Y., O'Donnell D., Haqqani H., Kotschet E., Swerdlow C.D., Zhang X., Sawchuk R., Greenhut S., Grinberg Y., Crozier I., Liu Y., O'Donnell D., Haqqani H., Kotschet E., Swerdlow C.D., Zhang X., Sawchuk R., Greenhut S., and Grinberg Y.

Abstract

OBJECTIVES: This study reports the sensing and arrhythmia detection performance of a novel extravascular (EV) implantable cardioverter-defibrillator (ICD) in a first-in-human pilot study. BACKGROUND: The EV ICD lead is implanted in the substernal space, resulting in novel sensing and detection challenges. It uses a programmable sensing profile with new or modified discrimination of oversensing and of ventricular tachycardia (VT) from supraventricular tachycardia (SVT). METHOD(S): Electrograms were post-processed from induced ventricular fibrillation (VF) at implant to determine virtual detection times for each programmable sensitivity and the least-sensitive safe sensitivity setting. In ambulatory patients, programmed sensitivity provided at least a twofold safety margin for detecting induced VF. Noise discrimination was stress tested, and the effects of source, posture, and lead maturation were determined on electrogram amplitude. Telemetry Holter monitors were used to quantify undersensing and oversensing. RESULT(S): In 20 patients at implant, the least-sensitive safe sensitivity for VF detection ranged from 0.1 to 0.6 mV. Seventeen patients were followed up for a total of 16.6 patient-years. Electrogram amplitudes were stable over time, but there were significant differences among postures and sensing vectors. For the primary sensing vector, the weighted oversensing and undersensing rates were 1.03% and 0.40% respectively, on a beat-to-beat basis. Oversensing did not cause inappropriate therapy in patients with in situ leads. Oversensing discriminators withheld VF detection in 4 of 5 spontaneous, sustained oversensed episodes. SVT-VT discriminators correctly classified 93% of 128 sustained SVTs in monitor zones. CONCLUSION(S): In the EV ICD pilot study, oversensing did not cause inappropriate therapy during ambulatory follow-up of stable leads.Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Published
2021

13. Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author

Kuhn, J.H., Adkins, S., Agwanda, B.R., Al Kubrusli, R., Alkhovsky, S.V., Amarasinghe, G.K., Avšič-Županc, T., Ayllón, M.A., Bahl, J., Balkema-Buschmann, A., Ballinger, M.J., Basler, C.F., Bavari, S., Beer, M., Bejerman, N., Bennett, A.J., Bente, D.A., Bergeron, É., Bird, B.H., Blair, C.D., Blasdell, K.R., Blystad, D-R, Bojko, J., Borth, W.B., Bradfute, S., Breyta, R., Briese, T., Brown, P.A., Brown, J.K., Buchholz, U.J., Buchmeier, M.J., Bukreyev, A., Burt, F., Büttner, C., Calisher, C.H., Cao, M., Casas, I., Chandran, K., Charrel, R.N., Cheng, Q., Chiaki, Y., Chiapello, M., Choi, I-R, Ciuffo, M., Clegg, J.C.S., Crozier, I., Dal Bó, E., de la Torre, J.C., de Lamballerie, X., de Swart, R.L., Debat, H., Dheilly, N.M., Di Cicco, E., Di Paola, N., Di Serio, F., Dietzgen, R.G., Digiaro, M., Dolnik, O., Drebot, M.A., Drexler, J.F., Dundon, W.G., Duprex, W.P., Dürrwald, R., Dye, J.M., Easton, A.J., Ebihara, H., Elbeaino, T., Ergünay, K., Ferguson, H.W., Fooks, A.R., Forgia, M., Formenty, P.B.H., Fránová, J., Freitas-Astúa, J., Fu, J., Fürl, S., Gago-Zachert, S., Gāo, G.F., García, M.L., García-Sastre, A., Garrison, A.R., Gaskin, T., Gonzalez, J-P.J., Griffiths, A., Goldberg, T.L., Groschup, M.H., Günther, S., Hall, R.A., Hammond, J., Han, T., Hepojoki, J., Hewson, R., Hong, J., Hong, N., Hongo, S., Horie, M., Hu, J.S., Hu, T., Hughes, H.R., Hüttner, F., Hyndman, T.H., Ilyas, M., Jalkanen, R., Jiāng, D., Jonson, G.B., Junglen, S., Kadono, F., Kaukinen, K.H., Kawate, M., Klempa, B., Klingström, J., Kobinger, G., Koloniuk, I., Kondo, H., Koonin, E.V., Krupovic, M., Kubota, K., Kurath, G., Laenen, L., Lambert, A.J., Langevin, S.L., Lee, B., Lefkowitz, E.J., Leroy, E.M., Li, S., Li, L., Lǐ, J., Liu, H., Lukashevich, I.S., Maes, P., de Souza, W.M., Marklewitz, M., Marshall, S.H., Marzano, S-Y.L., Massart, S., McCauley, J.W., Melzer, M., Mielke-Ehret, N., Miller, K.M., Ming, T.J., Mirazimi, A., Mordecai, G.J., Mühlbach, H-P, Mühlberger, E., Naidu, R., Natsuaki, T., Navarro, J.A., Netesov, S.V., Neumann, G., Nowotny, N., Nunes, M.R.T., Olmedo-Velarde, A., Palacios, G., Pallás, V., Pályi, B., Papa, A., Paraskevopoulou, S., Park, A.C., Parrish, C.R., Patterson, D.A., Pauvolid-Corrêa, A., Pawęska, J.T., Payne, S., Peracchio, C., Pérez, D.R., Postler, T.S., Qi, L., Radoshitzky, S.R., Resende, R.O., Reyes, C.A., Rima, B.K., Luna, G.R., Romanowski, V., Rota, P., Rubbenstroth, D., Rubino, L., Runstadler, J.A., Sabanadzovic, S., Sall, A.A., Salvato, M.S., Sang, R., Sasaya, T., Schulze, A.D., Schwemmle, M., Shi, M., Shí, X., Shí, Z., Shimomoto, Y., Shirako, Y., Siddell, S.G., Simmonds, P., Sironi, M., Smagghe, G., Smither, S., Song, J-W, Spann, K., Spengler, J.R., Stenglein, M.D., Stone, D.M., Sugano, J., Suttle, C.A., Tabata, A., Takada, A., Takeuchi, S., Tchouassi, D.P., Teffer, A., Tesh, R.B., Thornburg, N. J., Tomitaka, Y., Tomonaga, K., Tordo, N., Torto, B., Towner, J.S., Tsuda, S., Tu, C., Turina, M., Tzanetakis, I.E., Uchida, J., Usugi, T., Vaira, A.M., Vallino, M., van den Hoogen, B., Varsani, A., Vasilakis, N., Verbeek, M., von Bargen, S., Wada, J., Wahl, V., Walker, P.J., Wang, L-F, Wang, G., Wang, Y., Waqas, M., Wèi, T., Wen, S., Whitfield, A.E., Williams, J.V., Wolf, Y.I., Wu, J., Xu, L., Yanagisawa, H., Yang, C., Yang, Z., Zerbini, F.M., Zhai, L., Zhang, Y-Z, Zhang, S., Zhang, J., Zhang, Z., Zhou, X., Kuhn, J.H., Adkins, S., Agwanda, B.R., Al Kubrusli, R., Alkhovsky, S.V., Amarasinghe, G.K., Avšič-Županc, T., Ayllón, M.A., Bahl, J., Balkema-Buschmann, A., Ballinger, M.J., Basler, C.F., Bavari, S., Beer, M., Bejerman, N., Bennett, A.J., Bente, D.A., Bergeron, É., Bird, B.H., Blair, C.D., Blasdell, K.R., Blystad, D-R, Bojko, J., Borth, W.B., Bradfute, S., Breyta, R., Briese, T., Brown, P.A., Brown, J.K., Buchholz, U.J., Buchmeier, M.J., Bukreyev, A., Burt, F., Büttner, C., Calisher, C.H., Cao, M., Casas, I., Chandran, K., Charrel, R.N., Cheng, Q., Chiaki, Y., Chiapello, M., Choi, I-R, Ciuffo, M., Clegg, J.C.S., Crozier, I., Dal Bó, E., de la Torre, J.C., de Lamballerie, X., de Swart, R.L., Debat, H., Dheilly, N.M., Di Cicco, E., Di Paola, N., Di Serio, F., Dietzgen, R.G., Digiaro, M., Dolnik, O., Drebot, M.A., Drexler, J.F., Dundon, W.G., Duprex, W.P., Dürrwald, R., Dye, J.M., Easton, A.J., Ebihara, H., Elbeaino, T., Ergünay, K., Ferguson, H.W., Fooks, A.R., Forgia, M., Formenty, P.B.H., Fránová, J., Freitas-Astúa, J., Fu, J., Fürl, S., Gago-Zachert, S., Gāo, G.F., García, M.L., García-Sastre, A., Garrison, A.R., Gaskin, T., Gonzalez, J-P.J., Griffiths, A., Goldberg, T.L., Groschup, M.H., Günther, S., Hall, R.A., Hammond, J., Han, T., Hepojoki, J., Hewson, R., Hong, J., Hong, N., Hongo, S., Horie, M., Hu, J.S., Hu, T., Hughes, H.R., Hüttner, F., Hyndman, T.H., Ilyas, M., Jalkanen, R., Jiāng, D., Jonson, G.B., Junglen, S., Kadono, F., Kaukinen, K.H., Kawate, M., Klempa, B., Klingström, J., Kobinger, G., Koloniuk, I., Kondo, H., Koonin, E.V., Krupovic, M., Kubota, K., Kurath, G., Laenen, L., Lambert, A.J., Langevin, S.L., Lee, B., Lefkowitz, E.J., Leroy, E.M., Li, S., Li, L., Lǐ, J., Liu, H., Lukashevich, I.S., Maes, P., de Souza, W.M., Marklewitz, M., Marshall, S.H., Marzano, S-Y.L., Massart, S., McCauley, J.W., Melzer, M., Mielke-Ehret, N., Miller, K.M., Ming, T.J., Mirazimi, A., Mordecai, G.J., Mühlbach, H-P, Mühlberger, E., Naidu, R., Natsuaki, T., Navarro, J.A., Netesov, S.V., Neumann, G., Nowotny, N., Nunes, M.R.T., Olmedo-Velarde, A., Palacios, G., Pallás, V., Pályi, B., Papa, A., Paraskevopoulou, S., Park, A.C., Parrish, C.R., Patterson, D.A., Pauvolid-Corrêa, A., Pawęska, J.T., Payne, S., Peracchio, C., Pérez, D.R., Postler, T.S., Qi, L., Radoshitzky, S.R., Resende, R.O., Reyes, C.A., Rima, B.K., Luna, G.R., Romanowski, V., Rota, P., Rubbenstroth, D., Rubino, L., Runstadler, J.A., Sabanadzovic, S., Sall, A.A., Salvato, M.S., Sang, R., Sasaya, T., Schulze, A.D., Schwemmle, M., Shi, M., Shí, X., Shí, Z., Shimomoto, Y., Shirako, Y., Siddell, S.G., Simmonds, P., Sironi, M., Smagghe, G., Smither, S., Song, J-W, Spann, K., Spengler, J.R., Stenglein, M.D., Stone, D.M., Sugano, J., Suttle, C.A., Tabata, A., Takada, A., Takeuchi, S., Tchouassi, D.P., Teffer, A., Tesh, R.B., Thornburg, N. J., Tomitaka, Y., Tomonaga, K., Tordo, N., Torto, B., Towner, J.S., Tsuda, S., Tu, C., Turina, M., Tzanetakis, I.E., Uchida, J., Usugi, T., Vaira, A.M., Vallino, M., van den Hoogen, B., Varsani, A., Vasilakis, N., Verbeek, M., von Bargen, S., Wada, J., Wahl, V., Walker, P.J., Wang, L-F, Wang, G., Wang, Y., Waqas, M., Wèi, T., Wen, S., Whitfield, A.E., Williams, J.V., Wolf, Y.I., Wu, J., Xu, L., Yanagisawa, H., Yang, C., Yang, Z., Zerbini, F.M., Zhai, L., Zhang, Y-Z, Zhang, S., Zhang, J., Zhang, Z., and Zhou, X.

Abstract

Unfortunately, the inclusion of original names (in non-Latin script) of the following authors caused problems with author name indexing in PubMed. Therefore, these original names were removed from XML data to correct the PubMed record...

Published
2021

15. First-in-Human Chronic Implant Experience of the Substernal Extravascular Implantable Cardioverter-Defibrillator.

Author

Haqqani H., Shaw D., Prabhu A., Roubos N., Alison J., Melton I., Denman R., Almeida A., Portway B., Sawchuk R., Thompson A., Sherfesee L., Liang S., Lentz L., DeGroot P., Cheng A., O'Donnell D., Crozier I., Kotschet E., Lin T., Haqqani H., Shaw D., Prabhu A., Roubos N., Alison J., Melton I., Denman R., Almeida A., Portway B., Sawchuk R., Thompson A., Sherfesee L., Liang S., Lentz L., DeGroot P., Cheng A., O'Donnell D., Crozier I., Kotschet E., and Lin T.

Abstract

Objectives: The aim of this study was to evaluate the safety and performance of an extravascular (EV) implantable cardioverter-defibrillator (ICD). Background(s): Limitations of existing transvenous and subcutaneous ICD systems include lead reliability and morbidity issues associated with ICD lead implantation in the vasculature or lack of pacing therapies (e.g., antitachycardia pacing) in subcutaneous systems. The EV defibrillator uses a novel substernal lead placement to address these limitations. Method(s): This was a prospective, nonrandomized, chronic pilot study conducted at 4 centers in Australia and New Zealand. Participants were 21 patients referred for ICD implantation. Patients received EV ICD systems. Data collection included major systemic and procedural adverse events, defibrillation testing at implantation, and sensing and pacing thresholds. Result(s): Among 20 patients who underwent successful implantation, the median defibrillation threshold was 15 J, and 90% passed defibrillation testing with a >=10-J safety margin. Mean R-wave amplitude was 3.4 +/- 2.0 mV, mean ventricular fibrillation amplitude was 2.8 +/- 1.7 mV, and pacing was successful in 95% at <=10 V. There were no intraprocedural complications. Two patients have undergone elective chronic system removal since hospital discharge. In the 15 patients presently implanted, the systems are stable in long-term follow-up. Conclusion(s): This first-in-human evaluation of an EV ICD demonstrated the feasibility of substernal lead placement, defibrillation, and pacing with a chronically implanted system. There were no acute major complications, and pacing, defibrillation, and sensing performance at implantation were successful in most patients. (Extravascular ICD Pilot Study [EV ICD]; NCT03608670)Copyright © 2020 The Authors

Published
2020

16. 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author

Kuhn, J.H., Adkins, S., Alioto, D., Alkhovsky, S.V., Amarasinghe, G.K., Anthony, S.J., Avšič-Županc, T., Ayllón, M.A., Bahl, J., Balkema-Buschmann, A., Ballinger, M.J., Bartonička, T., Basler, C., Bavari, S., Beer, M., Bente, D.A., Bergeron, É., Bird, B.H., Blair, C., Blasdell, K.R., Bradfute, S.B., Breyta, R., Briese, T., Brown, P.A., Buchholz, U.J., Buchmeier, M.J., Bukreyev, A., Burt, F., Buzkan, N., Calisher, C.H., Cao, M., Casas, I., Chamberlain, J., Chandran, K., Charrel, R.N., Chen, B., Chiumenti, M., Choi, I-R, Clegg, J.C.S., Crozier, I., da Graça, J.V., Dal Bó, E., Dávila, A.M.R., de la Torre, J.C., de Lamballerie, X., de Swart, R.L., Di Bello, P.L., Di Paola, N., Di Serio, F., Dietzgen, R.G., Digiaro, M., Dolja, V.V., Dolnik, O., Drebot, M.A., Drexler, J.F., Dürrwald, R., Dufkova, L., Dundon, W.G., Duprex, W.P., Dye, J.M., Easton, A.J., Ebihara, H., Elbeaino, T., Ergünay, K., Fernandes, J., Fooks, A.R., Formenty, P.B.H., Forth, L.F., Fouchier, R.A.M., Freitas-Astúa, J., Gago-Zachert, S., Gāo, G.F., García, M.L., García-Sastre, A., Garrison, A.R., Gbakima, A., Goldstein, T., Gonzalez, J-P.J., Griffiths, A., Groschup, M.H., Günther, S., Guterres, A., Hall, R.A., Hammond, J., Hassan, M., Hepojoki, J., Hepojoki, S., Hetzel, U., Hewson, R., Hoffmann, B., Hongo, S., Höper, D., Horie, M., Hughes, H.R., Hyndman, T.H., Jambai, A., Jardim, R., Jiāng, D., Jin, Q., Jonson, G.B., Junglen, S., Karadağ, S., Keller, K.E., Klempa, B., Klingström, J., Kobinger, G., Kondō, H., Koonin, E.V., Krupovic, M., Kurath, G., Kuzmin, I.V., Laenen, L., Lamb, R.A., Lambert, A.J., Langevin, S.L., Lee, B., Lemos, E.R.S., Leroy, E.M., Li, D., Lǐ, J., Liang, M., Liú, W., Liú, Y., Lukashevich, I.S., Maes, P., Marciel de Souza, W., Marklewitz, M., Marshall, S.H., Martelli, G.P., Martin, R.R., Marzano, S-Y.L., Massart, S., McCauley, J.W., Mielke-Ehret, N., Minafra, A., Minutolo, M., Mirazimi, A., Mühlbach, H-P, Mühlberger, E., Naidu, R., Natsuaki, T., Navarro, B., Navarro, J.A., Netesov, S.V., Neumann, G., Nowotny, N., Nunes, M.R.T., Nylund, A., Økland, A.L., Oliveira, R.C., Palacios, G., Pallas, V., Pályi, B., Papa, A., Parrish, C.R., Pauvolid-Corrêa, A., Pawęska, J.T., Payne, S., Perez, D.R., Pfaff, F., Radoshitzky, S.R., Rahman, A-U, Ramos-González, P.L., Resende, R.O., Reyes, C.A., Rima, B.K., Romanowski, V., Robles Luna, G., Rota, P., Rubbenstroth, D., Runstadler, J.A., Ruzek, D., Sabanadzovic, S., Salat, J., Sall, A.A., Salvato, M.S., Sarpkaya, K., Sasaya, T., Schwemmle, M., Shabbir, M.Z., Shí, X., Shí, Z., Shirako, Y., Simmonds, P., Širmarová, J., Sironi, M., Smither, S., Smura, T., Song, J-W, Spann, K.M., Spengler, J.R., Stenglein, M.D., Stone, D.M., Straková, P., Takada, A., Tesh, R.B., Thornburg, N.J., Tomonaga, K., Tordo, N., Towner, J.S., Turina, M., Tzanetakis, I., Ulrich, R.G., Vaira, A.M., van den Hoogen, B., Varsani, A., Vasilakis, N., Verbeek, M., Wahl, V., Walker, P.J., Wang, H., Wang, J., Wang, X., Wang, L-F, Wèi, T., Wells, H., Whitfield, A.E., Williams, J.V., Wolf, Y.I., Wú, Z., Yang, X., Yáng, X., Yu, X., Yutin, N., Zerbini, F.M., Zhang, T., Zhang, Y-Z, Zhou, G., Zhou, X., Kuhn, J.H., Adkins, S., Alioto, D., Alkhovsky, S.V., Amarasinghe, G.K., Anthony, S.J., Avšič-Županc, T., Ayllón, M.A., Bahl, J., Balkema-Buschmann, A., Ballinger, M.J., Bartonička, T., Basler, C., Bavari, S., Beer, M., Bente, D.A., Bergeron, É., Bird, B.H., Blair, C., Blasdell, K.R., Bradfute, S.B., Breyta, R., Briese, T., Brown, P.A., Buchholz, U.J., Buchmeier, M.J., Bukreyev, A., Burt, F., Buzkan, N., Calisher, C.H., Cao, M., Casas, I., Chamberlain, J., Chandran, K., Charrel, R.N., Chen, B., Chiumenti, M., Choi, I-R, Clegg, J.C.S., Crozier, I., da Graça, J.V., Dal Bó, E., Dávila, A.M.R., de la Torre, J.C., de Lamballerie, X., de Swart, R.L., Di Bello, P.L., Di Paola, N., Di Serio, F., Dietzgen, R.G., Digiaro, M., Dolja, V.V., Dolnik, O., Drebot, M.A., Drexler, J.F., Dürrwald, R., Dufkova, L., Dundon, W.G., Duprex, W.P., Dye, J.M., Easton, A.J., Ebihara, H., Elbeaino, T., Ergünay, K., Fernandes, J., Fooks, A.R., Formenty, P.B.H., Forth, L.F., Fouchier, R.A.M., Freitas-Astúa, J., Gago-Zachert, S., Gāo, G.F., García, M.L., García-Sastre, A., Garrison, A.R., Gbakima, A., Goldstein, T., Gonzalez, J-P.J., Griffiths, A., Groschup, M.H., Günther, S., Guterres, A., Hall, R.A., Hammond, J., Hassan, M., Hepojoki, J., Hepojoki, S., Hetzel, U., Hewson, R., Hoffmann, B., Hongo, S., Höper, D., Horie, M., Hughes, H.R., Hyndman, T.H., Jambai, A., Jardim, R., Jiāng, D., Jin, Q., Jonson, G.B., Junglen, S., Karadağ, S., Keller, K.E., Klempa, B., Klingström, J., Kobinger, G., Kondō, H., Koonin, E.V., Krupovic, M., Kurath, G., Kuzmin, I.V., Laenen, L., Lamb, R.A., Lambert, A.J., Langevin, S.L., Lee, B., Lemos, E.R.S., Leroy, E.M., Li, D., Lǐ, J., Liang, M., Liú, W., Liú, Y., Lukashevich, I.S., Maes, P., Marciel de Souza, W., Marklewitz, M., Marshall, S.H., Martelli, G.P., Martin, R.R., Marzano, S-Y.L., Massart, S., McCauley, J.W., Mielke-Ehret, N., Minafra, A., Minutolo, M., Mirazimi, A., Mühlbach, H-P, Mühlberger, E., Naidu, R., Natsuaki, T., Navarro, B., Navarro, J.A., Netesov, S.V., Neumann, G., Nowotny, N., Nunes, M.R.T., Nylund, A., Økland, A.L., Oliveira, R.C., Palacios, G., Pallas, V., Pályi, B., Papa, A., Parrish, C.R., Pauvolid-Corrêa, A., Pawęska, J.T., Payne, S., Perez, D.R., Pfaff, F., Radoshitzky, S.R., Rahman, A-U, Ramos-González, P.L., Resende, R.O., Reyes, C.A., Rima, B.K., Romanowski, V., Robles Luna, G., Rota, P., Rubbenstroth, D., Runstadler, J.A., Ruzek, D., Sabanadzovic, S., Salat, J., Sall, A.A., Salvato, M.S., Sarpkaya, K., Sasaya, T., Schwemmle, M., Shabbir, M.Z., Shí, X., Shí, Z., Shirako, Y., Simmonds, P., Širmarová, J., Sironi, M., Smither, S., Smura, T., Song, J-W, Spann, K.M., Spengler, J.R., Stenglein, M.D., Stone, D.M., Straková, P., Takada, A., Tesh, R.B., Thornburg, N.J., Tomonaga, K., Tordo, N., Towner, J.S., Turina, M., Tzanetakis, I., Ulrich, R.G., Vaira, A.M., van den Hoogen, B., Varsani, A., Vasilakis, N., Verbeek, M., Wahl, V., Walker, P.J., Wang, H., Wang, J., Wang, X., Wang, L-F, Wèi, T., Wells, H., Whitfield, A.E., Williams, J.V., Wolf, Y.I., Wú, Z., Yang, X., Yáng, X., Yu, X., Yutin, N., Zerbini, F.M., Zhang, T., Zhang, Y-Z, Zhou, G., and Zhou, X.

Abstract

In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new genera were added, two were deleted, one was moved, and three were renamed. At the species rank, 160 species were added, four were deleted, ten were moved and renamed, and 30 species were renamed. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.

Published
2020

23. A Miller’s Tale

Author

Oldroyd, David, Dowe, Phil, Mackenzie, Adrian, Bashford, Alison, Bowker, Geoffrey C., Chalmers, Alan, Crozier, I. J., Dargavel, John, Riemens, Wendy, Dowling, Andrew, Forrest, Peter, Frankel, David, Garfield, Jay, Godfrey, Honor, Grout, Andrew, Hart, Phillip, Hooker, C. A., Luxford, Yvonne, Maelzer, Bronwyn, Martin, Brian, Rasmussen, Nicolas, Reingold, Nathan, Robin, Libby, Shortland, Michael, Sprod, Tim, Sutton, John, and Sysak, Janusz

Published
1997
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25. Shifting the paradigm - Applying universal standards of care to Ebola virus disease

Author

Crozier, I., Bausch, D.G., Mulangu, S., Muyembe, J.-J., Fischer, W.A., II, Diaz, J.V., Wohl, D.A., Kojan, R., and Jacob, S.T.

Abstract

As the Democratic Republic of Congo’s (DRC’s) 10th outbreak of Ebola virus disease (EVD) rages in this resource-limited, wartorn region, advances in the delivery of supportive care and the introduction of investigational therapies provide a glimmer of hope amid the mounting infections. In the absence of effective therapies or vaccines, EVD outbreak response has centered around the most basic of public health principles — identification and isolation of patients with suspected and confirmed EVD and tracking of all the contacts of the confirmed patients, who are then rapidly isolated if they show signs of disease. This strategy of “identify, isolate, and track” allows public health responders to curtail and eventually eliminate virus transmission in the community and has been the foundation of EVD outbreakcontrol efforts since the disease was first described in 1976.

Published
2019
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26. An integrated approach to emergency triage assessment and treatment in Uganda

Author

Kinoti, S.N., Burnett, S.M., Crozier, I, Kirunda, I, Mbonye, M.K., Naikoba, S, Ronald, A, Rubashembusya, T, Willis, K.S., and Weaver, M.R.

Abstract

Background: Reducing mortality among patients who present to primary referral facilities in need of emergency care requires efficient triage and immediate correct management known more commonly as Emergency Triage, Assessment and Treatment (ETAT). Integrated Management of Infectious Disease (IMID) training and on-site support (OSS) have been the tools used to build capacity among mid-level practitioners who have been found to be lacking in ETAT skills in the region.Objective: To investigate the use of Integrated Management of Infectious Disease (IMID) training and on-site support (OSS) tools to improve ETAT in health care facilities in rural Uganda.Design: Randomized mixed methods evaluation.Setting: Thirty-six facilities in Uganda were randomized 1:1 to arm A (IMID and OSS) and arm B (IMID alone).Subjects: Two mid-level practitioners, (clinical officers or senior nurses), from each facility participated in offsite IMID training. Staff at 18 facilities in arm A participated in OSS (two days each month of outreach and quality improvement for nine months).Results: Time series data on facility performance of three ETAT indicators were compared over 14 months and data on mortality among pediatric inpatients were compared across arms. Improvements differed across facilities and indicators, but steady improvement in triage occurred in arm A, with convergence across arms in the management of emergency patients. Analysis of baseline indicators and improvements demonstrated that facilities could improve their performance regardless of their starting point.Conclusion: IMID and OSS both improved the management of patients with an acute illness presenting to rural health facilities.

Published
2018

27. Taxonomy of the order Mononegavirales: update 2019

Author

Amarasinghe, G.K., Ayllón, M.A., Bào, Y., Basler, C.F., Bavari, S., Blasdell, K.R., Briese, T., Brown, P.A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U.J., Chabi-Jesus, C., Chandran, K., Chiapponi, C., Crozier, I., de Swart, R.L., Dietzgen, R.G., Dolnik, O., Drexler, J.F., Dürrwald, R., Dundon, W.G., Duprex, W.P., Dye, J.M., Easton, A.J., Fooks, A.R., Formenty, P.B.H., Fouchier, R.A.M., Freitas-Astúa, J., Griffiths, A., Hewson, R., Horie, M., Hyndman, T.H., Jiāng, D., Kitajima, E.W., Kobinger, G.P., Kondō, H., Kurath, G., Kuzmin, I.V., Lamb, R.A., Lavazza, A., Lee, B., Lelli, D., Leroy, E.M., Lǐ, J., Maes, P., Marzano, S-Y.L., Moreno, A., Mühlberger, E., Netesov, S.V., Nowotny, N., Nylund, A., Økland, A.L., Palacios, G., Pályi, B., Paweska, J.T., Payne, S.L., Prosperi, A., Ramos-González, P.L., Rima, B.K., Rota, P., Rubbenstroth, D., Shī, M., Simmonds, P., Smither, S.J., Sozzi, E., Spann, K., Stenglein, M.D., Stone, D.M., Takada, A., Tesh, R.B., Tomonaga, K., Tordo, N., Towner, J.S., van den Hoogen, B., Vasilakis, N., Wahl, V., Walker, P.J., Wang, L-F, Whitfield, A.E., Williams, J.V., Zerbini, F.M., Zhāng, T., Zhang, Y-Z, Kuhn, J.H., Amarasinghe, G.K., Ayllón, M.A., Bào, Y., Basler, C.F., Bavari, S., Blasdell, K.R., Briese, T., Brown, P.A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U.J., Chabi-Jesus, C., Chandran, K., Chiapponi, C., Crozier, I., de Swart, R.L., Dietzgen, R.G., Dolnik, O., Drexler, J.F., Dürrwald, R., Dundon, W.G., Duprex, W.P., Dye, J.M., Easton, A.J., Fooks, A.R., Formenty, P.B.H., Fouchier, R.A.M., Freitas-Astúa, J., Griffiths, A., Hewson, R., Horie, M., Hyndman, T.H., Jiāng, D., Kitajima, E.W., Kobinger, G.P., Kondō, H., Kurath, G., Kuzmin, I.V., Lamb, R.A., Lavazza, A., Lee, B., Lelli, D., Leroy, E.M., Lǐ, J., Maes, P., Marzano, S-Y.L., Moreno, A., Mühlberger, E., Netesov, S.V., Nowotny, N., Nylund, A., Økland, A.L., Palacios, G., Pályi, B., Paweska, J.T., Payne, S.L., Prosperi, A., Ramos-González, P.L., Rima, B.K., Rota, P., Rubbenstroth, D., Shī, M., Simmonds, P., Smither, S.J., Sozzi, E., Spann, K., Stenglein, M.D., Stone, D.M., Takada, A., Tesh, R.B., Tomonaga, K., Tordo, N., Towner, J.S., van den Hoogen, B., Vasilakis, N., Wahl, V., Walker, P.J., Wang, L-F, Whitfield, A.E., Williams, J.V., Zerbini, F.M., Zhāng, T., Zhang, Y-Z, and Kuhn, J.H.

Abstract

In February 2019, following the annual taxon ratification vote, the order Mononegavirales was amended by the addition of four new subfamilies and 12 new genera and the creation of 28 novel species. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV).

Published
2019

28. Taxonomy of the order Mononegavirales: Second update 2018

Author

Maes, P., Amarasinghe, G.K., Ayllón, M.A., Basler, C.F., Bavari, S., Blasdell, K.R., Briese, T., Brown, P.A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U.J., Chandran, K., Crozier, I., de Swart, R.L., Dietzgen, R.G., Dolnik, O., Domier, L.L., Drexler, J.F., Dürrwald, R., Dundon, W.G., Duprex, W.P., Dye, J.M., Easton, A.J., Fooks, A.R., Formenty, P.B.H., Fouchier, R.A.M., Freitas-Astúa, J., Ghedin, E., Griffiths, A., Hewson, R., Horie, M., Hurwitz, J.L., Hyndman, T.H., Jiāng, D., Kobinger, G.P., Kondō, H., Kurath, G., Kuzmin, I.V., Lamb, R.A., Lee, B., Leroy, E.M., Lǐ, J., Marzano, S-Y.L., Mühlberger, E., Netesov, S.V., Nowotny, N., Palacios, G., Pályi, B., Paweska, J.T., Payne, S.L., Rima, B.K., Rota, P., Rubbenstroth, D., Simmonds, P., Smither, S.J., Song, Q., Song, T., Spann, K., Stenglein, M.D., Stone, D.M., Takada, A., Tesh, R.B., Tomonaga, K., Tordo, N., Towner, J.S., van den Hoogen, B., Vasilakis, N., Wahl, V., Walker, P.J., Wang, D., Wang, L-F, Whitfield, A.E., Williams, J.V., Yè, G., Zerbini, F.M., Zhang, Y-Z, Kuhn, J.H., Maes, P., Amarasinghe, G.K., Ayllón, M.A., Basler, C.F., Bavari, S., Blasdell, K.R., Briese, T., Brown, P.A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U.J., Chandran, K., Crozier, I., de Swart, R.L., Dietzgen, R.G., Dolnik, O., Domier, L.L., Drexler, J.F., Dürrwald, R., Dundon, W.G., Duprex, W.P., Dye, J.M., Easton, A.J., Fooks, A.R., Formenty, P.B.H., Fouchier, R.A.M., Freitas-Astúa, J., Ghedin, E., Griffiths, A., Hewson, R., Horie, M., Hurwitz, J.L., Hyndman, T.H., Jiāng, D., Kobinger, G.P., Kondō, H., Kurath, G., Kuzmin, I.V., Lamb, R.A., Lee, B., Leroy, E.M., Lǐ, J., Marzano, S-Y.L., Mühlberger, E., Netesov, S.V., Nowotny, N., Palacios, G., Pályi, B., Paweska, J.T., Payne, S.L., Rima, B.K., Rota, P., Rubbenstroth, D., Simmonds, P., Smither, S.J., Song, Q., Song, T., Spann, K., Stenglein, M.D., Stone, D.M., Takada, A., Tesh, R.B., Tomonaga, K., Tordo, N., Towner, J.S., van den Hoogen, B., Vasilakis, N., Wahl, V., Walker, P.J., Wang, D., Wang, L-F, Whitfield, A.E., Williams, J.V., Yè, G., Zerbini, F.M., Zhang, Y-Z, and Kuhn, J.H.

Abstract

In October 2018, the order Mononegavirales was amended by the establishment of three new families and three new genera, abolishment of two genera, and creation of 28 novel species. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV).

Published
2019

33. PPA2 gene is involved in neonatal fatal acute dilated cardiomyopathy

Author

Moreau De Bellaing, A., primary, Guimier, A., additional, Bajolle, F., additional, Turner, C., additional, Grove, M., additional, Dunn, K., additional, Katta, G., additional, Crozier, I., additional, Kidd, A., additional, Mayr, J., additional, Rotig, A., additional, Di Rago, J.P., additional, Delahodde, A., additional, Lyonnet, S., additional, Doudney, K., additional, Kennedy, H., additional, Amiel, J., additional, Gordon, C., additional, and Bonnet, D., additional

Published
2019
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35. PPA2 gene is involved in neonatal fatal acute dilated cardiomyopathy

Author

Bellaing, A. Moreau de, primary, Guimier, A., additional, Bajolle, F., additional, Turner, C., additional, Grove, M., additional, Dunn, K., additional, Katta, G., additional, Crozier, I., additional, Kidd, A., additional, Mayr, J., additional, Rotig, A., additional, Di Rago, JP., additional, Delahodde, A., additional, Lyonnet, S., additional, Kennedy, H., additional, Doudney, K., additional, Amiel, J., additional, Gordon, C., additional, and Bonnet, D., additional

Published
2018
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38. Sudden Cardiac Death Due to Deficiency of the Mitochondrial Inorganic Pyrophosphatase PPA2

Author

Kennedy, H., Haack, T.B., Hartill, V., Matakovic, L., Baumgartner, E.R., Potter, H., Mackay, R., Alston, C.L., O'Sullivan, S., McFarland, R., Connolly, G., Gannon, C., King, R., Mead, S., Crozier, I., Chan, W., Florkowski, C.M., Sage, M., Hofken, T., Alhaddad, B., Kremer, L.S., Kopajtich, R., Feichtinger, R.G., Sperl, W., Rodenburg, R.J.T., Minet, J.C., Dobbie, A., Strom, T.M., Meitinger, T., George, P.M., Johnson, C.A., Taylor, R.W., Prokisch, H., Doudney, K., Mayr, J.A., Kennedy, H., Haack, T.B., Hartill, V., Matakovic, L., Baumgartner, E.R., Potter, H., Mackay, R., Alston, C.L., O'Sullivan, S., McFarland, R., Connolly, G., Gannon, C., King, R., Mead, S., Crozier, I., Chan, W., Florkowski, C.M., Sage, M., Hofken, T., Alhaddad, B., Kremer, L.S., Kopajtich, R., Feichtinger, R.G., Sperl, W., Rodenburg, R.J.T., Minet, J.C., Dobbie, A., Strom, T.M., Meitinger, T., George, P.M., Johnson, C.A., Taylor, R.W., Prokisch, H., Doudney, K., and Mayr, J.A.

Abstract

Contains fulltext : 171563.pdf (Publisher’s version ) (Open Access), We have used whole-exome sequencing in ten individuals from four unrelated pedigrees to identify biallelic missense mutations in the nuclear-encoded mitochondrial inorganic pyrophosphatase (PPA2) that are associated with mitochondrial disease. These individuals show a range of severity, indicating that PPA2 mutations may cause a spectrum of mitochondrial disease phenotypes. Severe symptoms include seizures, lactic acidosis, cardiac arrhythmia, and death within days of birth. In the index family, presentation was milder and manifested as cardiac fibrosis and an exquisite sensitivity to alcohol, leading to sudden arrhythmic cardiac death in the second decade of life. Comparison of normal and mutant PPA2-containing mitochondria from fibroblasts showed that the activity of inorganic pyrophosphatase was significantly reduced in affected individuals. Recombinant PPA2 enzymes modeling hypomorphic missense mutations had decreased activity that correlated with disease severity. These findings confirm the pathogenicity of PPA2 mutations and suggest that PPA2 is a cardiomyopathy-associated protein, which has a greater physiological importance in mitochondrial function than previously recognized.

Published
2016

49. Integrated microscopy techniques for comprehensive pathology evaluation of an implantable left atrial pressure sensor

Author

Roberts, A, primary, Trainor, K E, additional, Weeks, B, additional, Jackson, N, additional, Troughton, R W, additional, Charles, C J, additional, Rademaker, M T, additional, Melton, I C, additional, Crozier, I G, additional, Hafelfinger, W, additional, Gutfinger, D E, additional, Eigler, N L, additional, Abraham, W T, additional, and Clubb, F J, additional

Published
2013
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