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3. Altered microbial bile acid metabolism exacerbates T cell-driven inflammation during graft-versus-host disease

Author

Lindner, Sarah, Miltiadous, Oriana, Ramos, Ruben J. F., Paredes, Jenny, Kousa, Anastasia I., Dai, Anqi, Fei, Teng, Lauder, Emma, Frame, John, Waters, Nicholas R., Sadeghi, Keimya, Armijo, Gabriel K., Ghale, Romina, Victor, Kristen, Gipson, Brianna, Monette, Sebastien, Russo, Marco Vincenzo, Nguyen, Chi L., Slingerland, John, Taur, Ying, Markey, Kate A., Andrlova, Hana, Giralt, Sergio, Perales, Miguel-Angel, Reddy, Pavan, Peled, Jonathan U., Smith, Melody, Cross, Justin R., Burgos da Silva, Marina, Campbell, Clarissa, and van den Brink, Marcel R. M.

Published
2024
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6. Connecting copper and cancer: from transition metal signalling to metalloplasia

Author

Ge, Eva J, Bush, Ashley I, Casini, Angela, Cobine, Paul A, Cross, Justin R, DeNicola, Gina M, Dou, Q Ping, Franz, Katherine J, Gohil, Vishal M, Gupta, Sanjeev, Kaler, Stephen G, Lutsenko, Svetlana, Mittal, Vivek, Petris, Michael J, Polishchuk, Roman, Ralle, Martina, Schilsky, Michael L, Tonks, Nicholas K, Vahdat, Linda T, Van Aelst, Linda, Xi, Dan, Yuan, Peng, Brady, Donita C, and Chang, Christopher J

Subjects
2.1 Biological and endogenous factors, Aetiology, Cancer, Autophagy, Cell Proliferation, Copper, Humans, Neoplasms, Signal Transduction, Medical and Health Sciences, Oncology & Carcinogenesis
Abstract

Copper is an essential nutrient whose redox properties make it both beneficial and toxic to the cell. Recent progress in studying transition metal signalling has forged new links between researchers of different disciplines that can help translate basic research in the chemistry and biology of copper into clinical therapies and diagnostics to exploit copper-dependent disease vulnerabilities. This concept is particularly relevant in cancer, as tumour growth and metastasis have a heightened requirement for this metal nutrient. Indeed, the traditional view of copper as solely an active site metabolic cofactor has been challenged by emerging evidence that copper is also a dynamic signalling metal and metalloallosteric regulator, such as for copper-dependent phosphodiesterase 3B (PDE3B) in lipolysis, mitogen-activated protein kinase kinase 1 (MEK1) and MEK2 in cell growth and proliferation and the kinases ULK1 and ULK2 in autophagy. In this Perspective, we summarize our current understanding of the connection between copper and cancer and explore how challenges in the field could be addressed by using the framework of cuproplasia, which is defined as regulated copper-dependent cell proliferation and is a representative example of a broad range of metalloplasias. Cuproplasia is linked to a diverse array of cellular processes, including mitochondrial respiration, antioxidant defence, redox signalling, kinase signalling, autophagy and protein quality control. Identifying and characterizing new modes of copper-dependent signalling offers translational opportunities that leverage disease vulnerabilities to this metal nutrient.

Published
2022

10. Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease

Author

Docampo, Melissa D., da Silva, Marina B., Lazrak, Amina, Nichols, Katherine B., Lieberman, Sophia R., Slingerland, Ann E., Armijo, Gabriel K., Shono, Yusuke, Nguyen, Chi, Monette, Sebastien, Dwomoh, Emmanuel, Lee, Nicole, Geary, Clair D., Perobelli, Suelen M., Smith, Melody, Markey, Kate A., Vardhana, Santosha A., Kousa, Anastasia I., Zamir, Eli, Greenfield, Itamar, Sun, Joseph C., Cross, Justin R., Peled, Jonathan U., Jenq, Robert R., Stein-Thoeringer, Christoph K., and van den Brink, Marcel R.M.

Published
2022
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11. Characterization, structure and inhibition of the human succinyl-CoA:glutarate-CoA transferase, a genetic modifier of glutaric aciduria type 1

Author

Khamrui, Susmita, primary, Dodatko, Tetyana, additional, Wu, Ruoxi, additional, Leandro, João, additional, Sabovic, Amanda, additional, Violante, Sara, additional, Cross, Justin R., additional, Marsan, Eric, additional, Kumar, Kunal, additional, DeVita, Robert J., additional, Lazarus, Michael B., additional, and Houten, Sander M., additional

Published
2024
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13. A High-Fiber Dietary Intervention (NUTRIVENTION) in Precursor Plasma Cell Disorders Improves Disease Biomarkers and Delays Progression to Myeloma

Author

Shah, Urvi, primary, Cogrossi, Laura Lucia, additional, Derkach, Andriy, additional, Castro, Francesca, additional, Fei, Teng, additional, DeWolf, Susan, additional, Garces, Juan-Jose, additional, Policastro, Anna, additional, Grioni, Matteo, additional, Sisti, Sofia, additional, Blaslov, Jenna, additional, Adintori, Peter, additional, Hosszu, Kinga K., additional, McAvoy, Devin, additional, Baichoo, Mirae, additional, Cross, Justin R., additional, Anuraj, Aishwarya, additional, Pohl, Charlotte, additional, Ramos, Ruben, additional, Paredes, Jenny, additional, Gipson, Brianna, additional, Maclachlan, Kylee, additional, Gradissimo, Ana, additional, Boiocchi, Leonardo, additional, Koche, Richard, additional, Chaligne, Ronan, additional, Block, Torin, additional, Korde, Neha, additional, Tan, Carlyn Rose, additional, Hultcrantz, Malin, additional, Hassoun, Hani, additional, Shah, Gunjan, additional, Scordo, Michael, additional, Lahoud, Oscar B., additional, Chung, David J., additional, Landau, Heather J., additional, Peled, Jonathan U., additional, Clementi, Nicola, additional, Chesi, Marta, additional, Bergsagel, Peter, additional, Mailankody, Sham, additional, Pollak, Michael, additional, D'Souza, Anita, additional, Landgren, Ola, additional, Chimonas, Susan, additional, Giralt, Sergio A., additional, Usmani, Saad, additional, Iyengar, Neil M., additional, Lesokhin, Alexander, additional, Bellone, Matteo, additional, and van den Brink, Marcel R.M., additional

Published
2024
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16. Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase

Author

Savino, Angela Maria, Fernandes, Sara Isabel, Olivares, Orianne, Zemlyansky, Anna, Cousins, Antony, Markert, Elke K., Barel, Shani, Geron, Ifat, Frishman, Liron, Birger, Yehudit, Eckert, Cornelia, Tumanov, Sergey, MacKay, Gillian, Kamphorst, Jurre J., Herzyk, Pawel, Fernández-García, Jonatan, Abramovich, Ifat, Mor, Inbal, Bardini, Michela, Barin, Ersilia, Janaki-Raman, Sudha, Cross, Justin R., Kharas, Michael G., Gottlieb, Eyal, Izraeli, Shai, and Halsey, Christina

Published
2020
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18. Microbiota modulate sympathetic neurons via a gut–brain circuit

Author

Muller, Paul A., Schneeberger, Marc, Matheis, Fanny, Wang, Putianqi, Kerner, Zachary, Ilanges, Anoj, Pellegrino, Kyle, del Mármol, Josefina, Castro, Tiago B. R., Furuichi, Munehiro, Perkins, Matthew, Han, Wenfei, Rao, Arka, Pickard, Amanda J., Cross, Justin R., Honda, Kenya, de Araujo, Ivan, and Mucida, Daniel

Published
2020
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22. Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus

Author

Kim, Sohn G., Becattini, Simone, Moody, Thomas U., Shliaha, Pavel V., Littmann, Eric R., Seok, Ruth, Gjonbalaj, Mergim, Eaton, Vincent, Fontana, Emily, Amoretti, Luigi, Wright, Roberta, Caballero, Silvia, Wang, Zhong-Min X., Jung, Hea-Jin, Morjaria, Sejal M., Leiner, Ingrid M., Qin, Weige, Ramos, Ruben J. J. F., Cross, Justin R., Narushima, Seiko, Honda, Kenya, Peled, Jonathan U., Hendrickson, Ronald C., Taur, Ying, van den Brink, Marcel R. M., and Pamer, Eric G.

Published
2019
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27. Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

Author

Intlekofer, Andrew M., Shih, Alan H., Wang, Bo, Nazir, Abbas, Rustenburg, Ariën S., Albanese, Steven K., Patel, Minal, Famulare, Christopher, Correa, Fabian M., Takemoto, Naofumi, Durani, Vidushi, Liu, Hui, Taylor, Justin, Farnoud, Noushin, Papaemmanuil, Elli, Cross, Justin R., Tallman, Martin S., Arcila, Maria E., Roshal, Mikhail, Petsko, Gregory A., Wu, Bin, Choe, Sung, Konteatis, Zenon D., Biller, Scott A., Chodera, John D., Thompson, Craig B., Levine, Ross L., and Stein, Eytan M.

Published
2018
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28. Data from Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Author

Ye, Jiangbin, primary, Fan, Jing, primary, Venneti, Sriram, primary, Wan, Ying-Wooi, primary, Pawel, Bruce R., primary, Zhang, Ji, primary, Finley, Lydia W.S., primary, Lu, Chao, primary, Lindsten, Tullia, primary, Cross, Justin R., primary, Qing, Guoliang, primary, Liu, Zhandong, primary, Simon, M. Celeste, primary, Rabinowitz, Joshua D., primary, and Thompson, Craig B., primary

Published
2023
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29. Supplementary Table 1 from Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Author

Ye, Jiangbin, primary, Fan, Jing, primary, Venneti, Sriram, primary, Wan, Ying-Wooi, primary, Pawel, Bruce R., primary, Zhang, Ji, primary, Finley, Lydia W.S., primary, Lu, Chao, primary, Lindsten, Tullia, primary, Cross, Justin R., primary, Qing, Guoliang, primary, Liu, Zhandong, primary, Simon, M. Celeste, primary, Rabinowitz, Joshua D., primary, and Thompson, Craig B., primary

Published
2023
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30. Data from Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia

Author

Santomasso, Bianca D., primary, Park, Jae H., primary, Salloum, Darin, primary, Riviere, Isabelle, primary, Flynn, Jessica, primary, Mead, Elena, primary, Halton, Elizabeth, primary, Wang, Xiuyan, primary, Senechal, Brigitte, primary, Purdon, Terence, primary, Cross, Justin R., primary, Liu, Hui, primary, Vachha, Behroze, primary, Chen, Xi, primary, DeAngelis, Lisa M., primary, Li, Daniel, primary, Bernal, Yvette, primary, Gonen, Mithat, primary, Wendel, Hans-Guido, primary, Sadelain, Michel, primary, and Brentjens, Renier J., primary

Published
2023
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31. Figure S1, Figure S2, Figure S3, Figure S4 from Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia

Author

Santomasso, Bianca D., primary, Park, Jae H., primary, Salloum, Darin, primary, Riviere, Isabelle, primary, Flynn, Jessica, primary, Mead, Elena, primary, Halton, Elizabeth, primary, Wang, Xiuyan, primary, Senechal, Brigitte, primary, Purdon, Terence, primary, Cross, Justin R., primary, Liu, Hui, primary, Vachha, Behroze, primary, Chen, Xi, primary, DeAngelis, Lisa M., primary, Li, Daniel, primary, Bernal, Yvette, primary, Gonen, Mithat, primary, Wendel, Hans-Guido, primary, Sadelain, Michel, primary, and Brentjens, Renier J., primary

Published
2023
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32. Supplementary Figure 5 from Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Author

Ye, Jiangbin, primary, Fan, Jing, primary, Venneti, Sriram, primary, Wan, Ying-Wooi, primary, Pawel, Bruce R., primary, Zhang, Ji, primary, Finley, Lydia W.S., primary, Lu, Chao, primary, Lindsten, Tullia, primary, Cross, Justin R., primary, Qing, Guoliang, primary, Liu, Zhandong, primary, Simon, M. Celeste, primary, Rabinowitz, Joshua D., primary, and Thompson, Craig B., primary

Published
2023
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33. Supplementary Figure 2 from Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Author

Ye, Jiangbin, primary, Fan, Jing, primary, Venneti, Sriram, primary, Wan, Ying-Wooi, primary, Pawel, Bruce R., primary, Zhang, Ji, primary, Finley, Lydia W.S., primary, Lu, Chao, primary, Lindsten, Tullia, primary, Cross, Justin R., primary, Qing, Guoliang, primary, Liu, Zhandong, primary, Simon, M. Celeste, primary, Rabinowitz, Joshua D., primary, and Thompson, Craig B., primary

Published
2023
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34. Supplementary Figure 4 from Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Author

Ye, Jiangbin, primary, Fan, Jing, primary, Venneti, Sriram, primary, Wan, Ying-Wooi, primary, Pawel, Bruce R., primary, Zhang, Ji, primary, Finley, Lydia W.S., primary, Lu, Chao, primary, Lindsten, Tullia, primary, Cross, Justin R., primary, Qing, Guoliang, primary, Liu, Zhandong, primary, Simon, M. Celeste, primary, Rabinowitz, Joshua D., primary, and Thompson, Craig B., primary

Published
2023
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35. Supplementary Figure 1B from Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Author

Ye, Jiangbin, primary, Fan, Jing, primary, Venneti, Sriram, primary, Wan, Ying-Wooi, primary, Pawel, Bruce R., primary, Zhang, Ji, primary, Finley, Lydia W.S., primary, Lu, Chao, primary, Lindsten, Tullia, primary, Cross, Justin R., primary, Qing, Guoliang, primary, Liu, Zhandong, primary, Simon, M. Celeste, primary, Rabinowitz, Joshua D., primary, and Thompson, Craig B., primary

Published
2023
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36. Table S1, Table S2, Table S3, Table S4 from Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia

Author

Santomasso, Bianca D., primary, Park, Jae H., primary, Salloum, Darin, primary, Riviere, Isabelle, primary, Flynn, Jessica, primary, Mead, Elena, primary, Halton, Elizabeth, primary, Wang, Xiuyan, primary, Senechal, Brigitte, primary, Purdon, Terence, primary, Cross, Justin R., primary, Liu, Hui, primary, Vachha, Behroze, primary, Chen, Xi, primary, DeAngelis, Lisa M., primary, Li, Daniel, primary, Bernal, Yvette, primary, Gonen, Mithat, primary, Wendel, Hans-Guido, primary, Sadelain, Michel, primary, and Brentjens, Renier J., primary

Published
2023
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37. Supplementary Figure 3 from Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Author

Ye, Jiangbin, primary, Fan, Jing, primary, Venneti, Sriram, primary, Wan, Ying-Wooi, primary, Pawel, Bruce R., primary, Zhang, Ji, primary, Finley, Lydia W.S., primary, Lu, Chao, primary, Lindsten, Tullia, primary, Cross, Justin R., primary, Qing, Guoliang, primary, Liu, Zhandong, primary, Simon, M. Celeste, primary, Rabinowitz, Joshua D., primary, and Thompson, Craig B., primary

Published
2023
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38. Supplemental Figure 5 from Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor

Author

Vitiello, Gerardo A., primary, Medina, Benjamin D., primary, Zeng, Shan, primary, Bowler, Timothy G., primary, Zhang, Jennifer Q., primary, Loo, Jennifer K., primary, Param, Nesteene J., primary, Liu, Mengyuan, primary, Moral, Alec J., primary, Zhao, Julia N., primary, Rossi, Ferdinand, primary, Antonescu, Cristina R., primary, Balachandran, Vinod P., primary, Cross, Justin R., primary, and DeMatteo, Ronald P., primary

Published
2023
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39. Supplemental Figure 1 from Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor

Author

Vitiello, Gerardo A., primary, Medina, Benjamin D., primary, Zeng, Shan, primary, Bowler, Timothy G., primary, Zhang, Jennifer Q., primary, Loo, Jennifer K., primary, Param, Nesteene J., primary, Liu, Mengyuan, primary, Moral, Alec J., primary, Zhao, Julia N., primary, Rossi, Ferdinand, primary, Antonescu, Cristina R., primary, Balachandran, Vinod P., primary, Cross, Justin R., primary, and DeMatteo, Ronald P., primary

Published
2023
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40. Supplemental Fig.1-4;Supplemental Tables 1-3; Suipplemental Methods from Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial

Author

Xu, Ran, primary, Shimizu, Fumiko, primary, Hovinga, Koos, primary, Beal, Kathryn, primary, Karimi, Sasan, primary, Droms, Leif, primary, Peck, Kyung K., primary, Gutin, Philip, primary, Iorgulescu, J. Bryan, primary, Kaley, Thomas, primary, DeAngelis, Lisa, primary, Pentsova, Elena, primary, Nolan, Craig, primary, Grommes, Christian, primary, Chan, Timothy, primary, Bobrow, Dylan, primary, Hormigo, Adilia, primary, Cross, Justin R., primary, Wu, Nian, primary, Takebe, Naoko, primary, Panageas, Katherine, primary, Ivy, Percy, primary, Supko, Jeffrey G., primary, Tabar, Viviane, primary, and Omuro, Antonio, primary

Published
2023
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41. Supplemental Figure 3 from Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor

Author

Vitiello, Gerardo A., primary, Medina, Benjamin D., primary, Zeng, Shan, primary, Bowler, Timothy G., primary, Zhang, Jennifer Q., primary, Loo, Jennifer K., primary, Param, Nesteene J., primary, Liu, Mengyuan, primary, Moral, Alec J., primary, Zhao, Julia N., primary, Rossi, Ferdinand, primary, Antonescu, Cristina R., primary, Balachandran, Vinod P., primary, Cross, Justin R., primary, and DeMatteo, Ronald P., primary

Published
2023
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42. Supplemental Figure 4 from Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor

Author

Vitiello, Gerardo A., primary, Medina, Benjamin D., primary, Zeng, Shan, primary, Bowler, Timothy G., primary, Zhang, Jennifer Q., primary, Loo, Jennifer K., primary, Param, Nesteene J., primary, Liu, Mengyuan, primary, Moral, Alec J., primary, Zhao, Julia N., primary, Rossi, Ferdinand, primary, Antonescu, Cristina R., primary, Balachandran, Vinod P., primary, Cross, Justin R., primary, and DeMatteo, Ronald P., primary

Published
2023
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43. Supplemental Figure 2 from Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor

Author

Vitiello, Gerardo A., primary, Medina, Benjamin D., primary, Zeng, Shan, primary, Bowler, Timothy G., primary, Zhang, Jennifer Q., primary, Loo, Jennifer K., primary, Param, Nesteene J., primary, Liu, Mengyuan, primary, Moral, Alec J., primary, Zhao, Julia N., primary, Rossi, Ferdinand, primary, Antonescu, Cristina R., primary, Balachandran, Vinod P., primary, Cross, Justin R., primary, and DeMatteo, Ronald P., primary

Published
2023
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44. Microbial Bile Acid Metabolism Shapes Effector T Cell Responses during Graft-Versus-Host Disease in Mouse and Human

Author

Lindner, Sarah, primary, Miltiadous, Oriana, additional, Ramos, Ruben, additional, Dai, Anqi, additional, Kousa, Anastasia, additional, Sanchez, Jenny Paredes, additional, Fei, Teng, additional, Frame, John, additional, Nguyen, Chi L., additional, Armijo, Gabriel K, additional, Ghale, Romina, additional, Monette, Sebastien, additional, Slingerland, John, additional, Andrlova, Hana, additional, da Silva, Marina Burgos, additional, Taur, Ying, additional, Markey, Kate Ann, additional, Peled, Jonathan U., additional, Smith, Melody, additional, Giralt, Sergio A, additional, Perales, Miguel-Angel, additional, Cross, Justin R., additional, Campbell, Clarissa, additional, and van den Brink, Marcel R.M., additional

Published
2023
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45. Acyl‐CoA dehydrogenase substrate promiscuity: Challenges and opportunities for development of substrate reduction therapy in disorders of valine and isoleucine metabolism.

Author

Houten, Sander M., Dodatko, Tetyana, Dwyer, William, Violante, Sara, Chen, Hongjie, Stauffer, Brandon, DeVita, Robert J., Vaz, Frédéric M., Cross, Justin R., Yu, Chunli, and Leandro, João

Abstract

Toxicity of accumulating substrates is a significant problem in several disorders of valine and isoleucine degradation notably short‐chain enoyl‐CoA hydratase (ECHS1 or crotonase) deficiency, 3‐hydroxyisobutyryl‐CoA hydrolase (HIBCH) deficiency, propionic acidemia (PA), and methylmalonic aciduria (MMA). Isobutyryl‐CoA dehydrogenase (ACAD8) and short/branched‐chain acyl‐CoA dehydrogenase (SBCAD, ACADSB) function in the valine and isoleucine degradation pathways, respectively. Deficiencies of these acyl‐CoA dehydrogenase (ACAD) enzymes are considered biochemical abnormalities with limited or no clinical consequences. We investigated whether substrate reduction therapy through inhibition of ACAD8 and SBCAD can limit the accumulation of toxic metabolic intermediates in disorders of valine and isoleucine metabolism. Using analysis of acylcarnitine isomers, we show that 2‐methylenecyclopropaneacetic acid (MCPA) inhibited SBCAD, isovaleryl‐CoA dehydrogenase, short‐chain acyl‐CoA dehydrogenase and medium‐chain acyl‐CoA dehydrogenase, but not ACAD8. MCPA treatment of wild‐type and PA HEK‐293 cells caused a pronounced decrease in C3‐carnitine. Furthermore, deletion of ACADSB in HEK‐293 cells led to an equally strong decrease in C3‐carnitine when compared to wild‐type cells. Deletion of ECHS1 in HEK‐293 cells caused a defect in lipoylation of the E2 component of the pyruvate dehydrogenase complex, which was not rescued by ACAD8 deletion. MCPA was able to rescue lipoylation in ECHS1 KO cells, but only in cells with prior ACAD8 deletion. SBCAD was not the sole ACAD responsible for this compensation, which indicates substantial promiscuity of ACADs in HEK‐293 cells for the isobutyryl‐CoA substrate. Substrate promiscuity appeared less prominent for 2‐methylbutyryl‐CoA at least in HEK‐293 cells. We suggest that pharmacological inhibition of SBCAD to treat PA should be investigated further. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease

Author

Jenq, Robert R., Taur, Ying, Devlin, Sean M., Ponce, Doris M., Goldberg, Jenna D., Ahr, Katya F., Littmann, Eric R., Ling, Lilan, Gobourne, Asia C., Miller, Liza C., Docampo, Melissa D., Peled, Jonathan U., Arpaia, Nicholas, Cross, Justin R., Peets, Tatanisha K., Lumish, Melissa A., Shono, Yusuke, Dudakov, Jarrod A., Poeck, Hendrik, Hanash, Alan M., Barker, Juliet N., Perales, Miguel-Angel, Giralt, Sergio A., Pamer, Eric G., and van den Brink, Marcel R.M.

Published
2015
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47. A Pilot Plant Based Dietary Intervention in MGUS and SMM Patients with Elevated BMI Is Feasible and Associated with Improvements in Metabolic and Microbiome Biomarkers of Progression

Author

Shah, Urvi A., primary, Derkach, Andriy, additional, Castro, Francesca, additional, Anuraj, Aishwarya, additional, Blaslov, Jenna, additional, Tran, Linh, additional, Adintori, Peter A., additional, Burge, Miranda, additional, Funkhouser, Sharon, additional, Hosszu, Kinga, additional, Cross, Justin R., additional, Pollak, Michael N., additional, McAvoy, Devin P., additional, Nemirovsky, David, additional, Maclachlan, Kylee H., additional, Mailankody, Sham, additional, Korde, Neha, additional, Tan, Carlyn, additional, Hultcrantz, Malin, additional, Patel, Dhwani, additional, Hassoun, Hani, additional, Shah, Gunjan L., additional, Scordo, Michael, additional, Lahoud, Oscar B., additional, Chung, David J., additional, Mayerhoefer, Marius E., additional, Peled, Jonathan U., additional, Landau, Heather, additional, D'Souza, Anita, additional, Landgren, Ola, additional, Giralt, Sergio A., additional, Iyengar, Neil M., additional, Usmani, Saad, additional, van den Brink, Marcel R.M., additional, and Lesokhin, Alexander M., additional

Published
2022
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48. A Randomized Placebo Controlled Study of a Plant-Based Dietary Versus Supplement Versus Placebo Intervention in Patients with Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Multiple Myeloma (SMM) - the Nutrition Prevention (NUTRIVENTION-3) Study

Author

Shah, Urvi A., primary, Castro, Francesca, additional, Anuraj, Aishwarya, additional, Schach, Eliana, additional, Derkach, Andriy, additional, Joseph, Nisha S., additional, Adintori, Peter A., additional, Guttentag, Laura, additional, Blaslov, Jenna, additional, Cross, Justin R., additional, Maclachlan, Kylee H., additional, Mailankody, Sham, additional, Korde, Neha, additional, Tan, Carlyn, additional, Hultcrantz, Malin, additional, Hassoun, Hani, additional, Lahoud, Oscar B., additional, Shah, Gunjan L., additional, Scordo, Michael, additional, Peled, Jonathan U., additional, Chung, David J., additional, Landau, Heather, additional, Mao, Jun J., additional, Iyengar, Neil M., additional, Usmani, Saad, additional, Giralt, Sergio A., additional, van den Brink, Marcel R.M., additional, and Lesokhin, Alexander M., additional

Published
2022
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49. Fructose Treatment Targets Myeloid Leukemogenesis in IDH2 Mutants By Exhausting Alpha-Ketoglutarate Pools

Author

Savino, Angela Maria, primary, Turner, Briana, additional, Jeong, Sangmoo, additional, Schild, Tanya, additional, Yang, Xuejing, additional, Luo, Hanzhi, additional, Chirayil, Rachel, additional, Cullen, Quinlan, additional, Chan, Mandy, additional, Han, Grace, additional, Chang, Kathryn, additional, Raman, Sudha Janaki, additional, Cross, Justin R, additional, Keshari, Kayvan, additional, and Kharas, Michael G, additional

Published
2022
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50. Ogdh Is a Genetic Vulnerability and Therapeutic Target in Acute Myeloid Leukemia

Author

Millman, Scott E, primary, Chaves-Perez, Almudena, additional, Morris, John P, additional, Chen, Chi-Chao, additional, Ho, Yu-Jui, additional, Raman, Sudha Janaki, additional, Yashinskie, Jossie J, additional, Mezzadra, Riccardo, additional, Narendra, Varun, additional, Tian, Sha, additional, Wuest, Alexandra, additional, Luan, Wei, additional, Cross, Justin R, additional, Finley, Lydia WS, additional, and Lowe, Scott W, additional

Published
2022
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