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483 results on '"Cross, J H."'

1. Iron and infection : neonatal iron transition

Author

Cross, J. H., Cerami, C., and Prentice, A. M.

Subjects
618.92
Abstract

Neonates, particularly those born preterm (PTB) and low birthweight (LBW), are especially susceptible to bacterial infections that cause an estimated 225,000 deaths annually. Iron is a vital substrate for the most common organisms causing septicaemia. Full-term babies elicit an immediate post-natal hypoferremia assumed to have evolved as an innate defence. This thesis aimed to test whether preterm and low birthweight newborns are capable of a similar response. A longitudinal observational study was conducted in 430 hospital-delivered Gambian babies. Demographic, anthropometric and haematological data were collected from 152 babies who were either PTB (between ≥32- < 37 weeks gestational age) and/or LBW (< 2500g) (PTB/LBW) and 278 full-term, normal-weight babies (FTB/NBW). Blood was sampled from the umbilical cord and matched venous blood samples from all neonates between 6-24 hours after delivery. An additional matched venous blood sample was taken from all full-term, normal birth weight newborns between 24-192 hours of life. In both FTB/NBW and PTB/LBW neonates, serum iron decreased 3-fold compared to umbilical blood concentrations within 12h of delivery (23·3±0·35 vs 7·5±0·22 ng/ml, P < 0.001, n=425). Hepcidin levels doubled (27·0±0·96 vs 52·9±1·63 ng/ml, P < 0·001, n=425). In FTB/NBW neonates, a steady increase in serum iron and TSAT follows (to 16.5±3.9μmol/L and 36.7±9.2% respectively by 136-192hrs postdelivery), even in the presence of relatively high serum hepcidin levels (45.2±19.1ng/ml) suggestive of hepcidin resistance possibly caused by iron saturation of macrophages. Our findings confirm that a very rapid hypoferremia occurs in the early hours of post-natal life with evidence that it is mediated by an increase in hepcidin. The strength and consistency of this effect in all neonates indicates that it may have evolved as an innate immune response designed to protect newborns from bacterial septicaemia.

Published
2020
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2. Effect of Fenfluramine on Generalized Tonic–Clonic Seizures in Rare Epilepsy Syndromes: A Review of Published Studies.

Author

Cross, J. H., Devinsky, O., Gil-Nagel, A., Ceulemans, B., Lagae, L., Schoonjans, A.-S., Ryvlin, P., Nabbout, R., Haas, S., Lothe, A., and Polega, S.

Subjects
*EPILEPSY, *SEIZURES (Medicine), *FENFLURAMINE, *SYNDROMES, *PEOPLE with epilepsy, *SUDDEN death
Abstract

This article, published in Neuropediatrics, reviews the effectiveness of fenfluramine (FFA) in treating generalized tonic-clonic seizures (GTCS) or tonic-clonic seizures (TCS) in patients with rare epilepsy syndromes. The study included data from 13 studies, including randomized-controlled trials, observational studies, open-label studies, and a case series. The results showed that FFA led to a clinically significant reduction in GTCS or TCS frequency in patients with rare epilepsy syndromes. However, further research is needed to determine the impact of FFA on sudden unexpected death in epilepsy (SUDEP) in these patient populations. [Extracted from the article]

Published
2023
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3. Individualized prediction of seizure relapse and outcomes following antiepileptic drug withdrawal after pediatric epilepsy surgery

Author

Lamberink, Herm J., Boshuisen, Kim, Otte, Willem M., Geleijns, Karin, Braun, Kees P. J., Feucht, M, Gröppel, G, Kahane, P, Minotti, L, Arzimanoglou, A, Ryvlin, P, Panagiotakaki, E, de Bellescize, J, Ostrowsky‐Coste, K, Hirsch, E, Valenti, M, Polster, T, Sassen, R, Hoppe, C, Kuczaty, S, Elger, C, Schubert, S, Strobl, K, Bast, T, Barba, C, Guerrini, R, Giordano, F, Francione, S, Caputo, D, Boshuisen, K, Braun, K P J, Uiterwaal, C S P M, van Nieuwenhuizen, O, Leijten, F S, van Rijen, P C, Seeck, M, Yalnizoglu, D, Turanli, G, Topcu, M, Özkara, C, Uzan, M, Cross, J H, DʼArgenzio, L, and Harkness, W

Published
2018
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4. Capillariasis

Author

Cross, J. H., Belizario, V., Black, Samuel J., editor, Seed, J. Richard, editor, Murrell, K. Darwin, editor, and Fried, Bernard, editor

Published
2007
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17. Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation

Author

Barba, Maria Cristina, Cross, J. H., Braun, K., Cossu, M., Klotz, K. A., De Masi, S., Perez Jimenez, M. A., Gaily, E., Specchio, N., Cabral, P., Toulouse, J., Dimova, P., Battaglia, Domenica Immacolata, Freri, E., Consales, A., Cesaroni, E., Tarta-Arsene, O., Gil-Nagel, A., Mindruta, I., Di Gennaro, G., Giulioni, M., Tisdall, M. M., Eltze, C., Tahir, M. Z., Jansen, F., van Rijen, P., Sanders, M., Tassi, L., Francione, S., Lo Russo, G., Jacobs, J., Bast, T., Matta, G., Budke, M., Fournier del Castillo, C., Metsahonkala, E. -L., Karppinen, A., Ferreira, J. C., Minkin, K., Marras, C. E., Arzimanoglou, A., Guerrini, R., Barba C., Battaglia D. (ORCID:0000-0003-0491-4021), Barba, Maria Cristina, Cross, J. H., Braun, K., Cossu, M., Klotz, K. A., De Masi, S., Perez Jimenez, M. A., Gaily, E., Specchio, N., Cabral, P., Toulouse, J., Dimova, P., Battaglia, Domenica Immacolata, Freri, E., Consales, A., Cesaroni, E., Tarta-Arsene, O., Gil-Nagel, A., Mindruta, I., Di Gennaro, G., Giulioni, M., Tisdall, M. M., Eltze, C., Tahir, M. Z., Jansen, F., van Rijen, P., Sanders, M., Tassi, L., Francione, S., Lo Russo, G., Jacobs, J., Bast, T., Matta, G., Budke, M., Fournier del Castillo, C., Metsahonkala, E. -L., Karppinen, A., Ferreira, J. C., Minkin, K., Marras, C. E., Arzimanoglou, A., Guerrini, R., Barba C., and Battaglia D. (ORCID:0000-0003-0491-4021)

Abstract

Objective: To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015. Methods: We collected information on volumes and types of surgery, pathology, and seizure outcome from 20 recognized epilepsy surgery reference centers in 10 European countries. Results: We analyzed retrospective aggregate data on 1859 operations. The proportion of surgeries significantly increased over time (P <.0001). Engel class I outcome was achieved in 69.3% of children, with no significant improvement between 2008 and 2015. The proportion of histopathological findings consistent with glial scars significantly increased between the ages of 7 and 16 years (P for trend =.0033), whereas that of the remaining pathologies did not vary across ages. A significant increase in unilobar extratemporal surgeries (P for trend =.0047) and a significant decrease in unilobar temporal surgeries (P for trend =.0030) were observed between 2008 and 2015. Conversely, the proportion of multilobar surgeries and unrevealing magnetic resonance imaging cases remained unchanged. Invasive investigations significantly increased, especially stereo-electroencephalography. We found different trends comparing centers starting their activity in the 1990s to those whose programs were developed in the past decade. Multivariate analysis revealed a significant variability of the proportion of the different pathologies and surgical approaches across countries, centers, and age groups between 2008 and 2015. Significance: Between 2008 and 2015, we observed a significant increase in the volume of pediatric epilepsy surgeries, stability in the proportion of Engel class I outcomes, and a modest increment in complexity of the procedures.

Published
2020

31. Epilepsies post cerebral infections

Author

Arzimanoglou, A, Cross, J H, Gaillard, W D, Holthausen, H, Jayakar, P, Kahane, P, Mathern, G, Arzimanoglou, A ( A ), Cross, J H ( J H ), Gaillard, W D ( W D ), Holthausen, H ( H ), Jayakar, P ( P ), Kahane, P ( P ), Mathern, G ( G ), Ramantani, G, Arzimanoglou, A, Cross, J H, Gaillard, W D, Holthausen, H, Jayakar, P, Kahane, P, Mathern, G, Arzimanoglou, A ( A ), Cross, J H ( J H ), Gaillard, W D ( W D ), Holthausen, H ( H ), Jayakar, P ( P ), Kahane, P ( P ), Mathern, G ( G ), and Ramantani, G

Published
2017

33. Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation

Author

Barba, C., Cross, J. H., Braun, K., Cossu, M., Klotz, K. A., De Masi, S., Perez Jimenez, M. A., Gaily, E., Specchio, N., Cabral, P., Toulouse, J., Dimova, P., Battaglia, D., Freri, E., Consales, A., Cesaroni, E., Tarta-Arsene, O., Gil-Nagel, A., Mindruta, I., Di Gennaro, G., Giulioni, M., Tisdall, M. M., Eltze, C., Tahir, M. Z., Jansen, F., van Rijen, P., Sanders, M., Tassi, L., Francione, S., Lo Russo, G., Jacobs, J., Bast, T., Matta, G., Budke, M., Fournier del Castillo, C., Metsahonkala, E. -L., Karppinen, A., Ferreira, J. C., Minkin, K., Marras, C. E., Lucenteforte, E, Arzimanoglou, A., and Guerrini, R.

Subjects
0301 basic medicine, Male, medicine.medical_specialty, Multivariate analysis, Adolescent, Neurosurgery, Stereoelectroencephalography, Neurosurgical Procedures, 03 medical and health sciences, Epilepsy, Settore MED/39 - NEUROPSICHIATRIA INFANTILE, 0302 clinical medicine, children, Seizures, Medicine, Humans, survey, Epilepsy surgery, Preschool, Child, Retrospective Studies, medicine.diagnostic_test, business.industry, Age Factors, Magnetic resonance imaging, Retrospective cohort study, Electroencephalography, medicine.disease, Magnetic Resonance Imaging, Temporal Lobe, 3. Good health, Surgery, Europe, epilepsy surgery, histopathology, outcome, Child, Preschool, Female, Treatment Outcome, 030104 developmental biology, Neurology, Histopathology, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

OBJECTIVE: To profile European trends in pediatric epilepsy surgery (

Published
2019

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