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1. Role of the Microbiome in Regulating Bone Metabolism and Susceptibility to Osteoporosis

Author

Cronin, Owen, Lanham-New, Susan A., Corfe, Bernard M., Gregson, Celia L., Darling, Andrea L., Ahmadi, Kourosh R., Gibson, Philippa S., Tobias, Jon H., Ward, Kate A., Traka, Maria H., Rossi, Megan, Williams, Claire, Harvey, Nicholas C., Cooper, Cyrus, Whelan, Kevin, Uitterlinden, André G., O’Toole, Paul W., Ohlsson, Claes, Compston, Juliet E., and Ralston, Stuart H.

Published
2022
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4. Randomised trial of genetic testing and targeted intervention to prevent the development and progression of Paget’s disease of bone

Author

Phillips, Jonathan, primary, Subedi, Deepak, additional, Lewis, Steff C, additional, Keerie, Catriona, additional, Cronin, Owen, additional, Porteous, Mary, additional, Moore, David, additional, Cetnarskyj, Roseanne, additional, Ranganath, Lakshminarayan, additional, Selby, Peter L, additional, Turgut, Tolga, additional, Hampson, Geeta, additional, Chandra, Rama, additional, Ho, Shu, additional, Tobias, Jon, additional, Young-Min, Steven, additional, McKenna, Malachi J, additional, Crowley, Rachel K, additional, Fraser, William D, additional, Tang, Jonathan C Y, additional, Gennari, Luigi, additional, Nuti, Rannuccio, additional, Brandi, Maria Luisa, additional, Del Pino-Montes, Javier, additional, Devogelaer, Jean-Pierre, additional, Durnez, Anne, additional, Isaia, Giovanni Carlo, additional, Di Stefano, Marco, additional, Guanabens, Nuria, additional, Blanch Rubio, Josep, additional, Seibel, Markus J, additional, Walsh, John P, additional, Rea, Sarah L, additional, Kotowicz, Mark A, additional, Nicholson, Geoffrey C, additional, Duncan, Emma L, additional, Major, Gabor, additional, Horne, Anne, additional, Gilchrist, Nigel, additional, and Ralston, Stuart H, additional

Published
2023
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6. Randomised trial of genetic testing and targeted intervention to prevent the development and progression of Paget's disease of bone.

Author

Phillips, Jonathan, Subedi, Deepak, Lewis, Steff C., Keerie, Catriona, Cronin, Owen, Porteous, Mary, Moore, David, Cetnarskyj, Roseanne, Ranganath, Lakshminarayan, Selby, Peter L., Turgut, Tolga, Hampson, Geeta, Chandra, Rama, Shu Ho, Tobias, Jon, Young-Min, Steven, McKenna, Malachi J., Crowley, Rachel K., Fraser, William D., and Tang, Jonathan C. Y.

Published
2024
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12. Tocilizumab for the treatment of giant cell arteritis in Scotland: a report on behalf of the Scottish Society for Rheumatology standards subgroup

Author

Cronin, Owen, primary, Preston, Hannah, additional, Fahmy, Heba, additional, Kuske, Barbara, additional, Singh, Malinder, additional, Scott, Naomi, additional, Kerrigan, Sean, additional, Moran, Lucy, additional, Harvie, John, additional, Harris, Helen, additional, Hauser, Barbara, additional, and McKay, Neil D, additional

Published
2022
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13. Role of the Microbiome in Regulating Bone Metabolism and Susceptibility to Osteoporosis

Author

Cronin, Owen, primary, Lanham-New, Susan A., additional, Corfe, Bernard M., additional, Gregson, Celia L., additional, Darling, Andrea L., additional, Ahmadi, Kourosh R., additional, Gibson, Philippa S., additional, Tobias, Jon H., additional, Ward, Kate A., additional, Traka, Maria H., additional, Rossi, Megan, additional, Williams, Claire, additional, Harvey, Nicholas C., additional, Cooper, Cyrus, additional, Whelan, Kevin, additional, Uitterlinden, André G., additional, O’Toole, Paul W., additional, Ohlsson, Claes, additional, Compston, Juliet E., additional, and Ralston, Stuart H., additional

Published
2021
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17. Characteristics of early Paget's disease in SQSTMI mutation carriers:baseline analysis of the ZIPP study cohort

Author

Cronin, Owen, Subedi, Deepak, Forsyth, Laura, Goodman, Kirsteen, Lewis, Steff C., Keerie, Catriona, Walker, Allan, Porteous, Mary, Cetnarskyj, Roseanne, Ranganath, Lakshminarayan R., Selby, Peter, Hampson, Geeta, Chandra, Rama, Ho, Shu, Tobias, Jonathan H, Young-Min, Steven, McKenna, Malachi J., Crowley, Rachel K., Fraser, William D, Tang, Jonathan, Gennari, Luigi, Nuti, Rannuccio, Brandi, Maria Luisa, Del Pino-Montes, Javier, Devogelaer, Jean-Pierre, Durnez, Anne, Isaia, Giovanni Carlo, Di Stefano, Marco, Rubio, Josep Blanch, Guañabens, Núria, Seibel, Markus J., Walsh, John P, Kotowicz, Mark A., Nicholson, Geoffrey C., Duncan, Emma L, Major, Gabor, Horne, Anne, Gilchrist, Nigel L., and Ralston, Stuart H.

Subjects
SQSTM1, genetics, Paget’s disease of bone, radionuclide imaging
Abstract

Objectives: Mutations in SQSTM1 are strongly associated with Paget’s disease of bone (PDB) but little is known about the clinical characteristics of those with early disease. Methods: Radionuclide bone scans, biochemical markers of bone turnover and clinical characteristics were analysed in SQSTM1 mutation carriers who took part in the Zoledronic acid in the Prevention of Paget’s disease (ZiPP) study. Results: We studied 222 individuals of whom 54.9% were female with average (± sem) age of 50.1± 0.6 years. Twelve SQSTM1 mutations were observed, including p.Pro392Leu which was present in 141/222 (63.5%) subjects. Bone scan examination revealed evidence of PDB in 20 subjects (9.0%) of which 9 (50%) had a single affected site. Participants with lesions were older than those without lesions but the difference was not significant (53.6 ± 9.1 vs. 49.8 ± 8.9, p=0.07). The mean age of participants with lesions was not significantly different from the age at which their parents were diagnosed with PDB (55 years vs. 59 years, p=0.25). All individuals with lesions were asymptomatic. Serum concentrations of total alkaline phosphatase (ALP) normalised to the upper limit of normal in each centre were higher in those with lesions (0.75 ± 0.69 vs 0.42 ± 0.29; pConclusions: Asymptomatic PDB is present in about 9% of SQSTM1 mutation carriers by the fifth decade. Further follow up of this cohort will provide important information on the natural history of early PDB and its response to treatment

Published
2020
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18. Characteristics of Early Paget's Disease in SQSTM1 Mutation Carriers: Baseline Analysis of the ZiPP Study Cohort

Author

Cronin, Owen, Subedi, Deepak, Forsyth, Laura, Goodman, Kirsteen, Lewis, Steff C., Keerie, Catriona, Walker, Allan, Porteous, Mary, Cetnarskyj, Roseanne, Ranganath, Lakshminarayan R., Selby, Peter L., Hampson, Geeta, Chandra, Rama, Ho, Shu, Tobias, Jon H., Young-Min, Steven A., McKenna, Malachi J., Crowley, Rachel K., Fraser, William D., Tang, Jonathan, Gennari, Luigi, Nuti, Rannuccio, Brandi, Maria Luisa, del Pino-Montes, Javier, Devogelaer, Jean Pierre, Durnez, Anne, Isaia, Giovanni Carlo, Di Stefano, Marco, Rubio, Josep Blanch, Guanabens, Nuria, Seibel, Markus J., Walsh, John P., Kotowicz, Mark A., Nicholson, Geoffrey C., Duncan, Emma L., Major, Gabor, Horne, Anne, Gilchrist, Nigel L., Ralston, Stuart H., Cronin, Owen, Subedi, Deepak, Forsyth, Laura, Goodman, Kirsteen, Lewis, Steff C., Keerie, Catriona, Walker, Allan, Porteous, Mary, Cetnarskyj, Roseanne, Ranganath, Lakshminarayan R., Selby, Peter L., Hampson, Geeta, Chandra, Rama, Ho, Shu, Tobias, Jon H., Young-Min, Steven A., McKenna, Malachi J., Crowley, Rachel K., Fraser, William D., Tang, Jonathan, Gennari, Luigi, Nuti, Rannuccio, Brandi, Maria Luisa, del Pino-Montes, Javier, Devogelaer, Jean Pierre, Durnez, Anne, Isaia, Giovanni Carlo, Di Stefano, Marco, Rubio, Josep Blanch, Guanabens, Nuria, Seibel, Markus J., Walsh, John P., Kotowicz, Mark A., Nicholson, Geoffrey C., Duncan, Emma L., Major, Gabor, Horne, Anne, Gilchrist, Nigel L., and Ralston, Stuart H.

Abstract

Mutations in SQSTM1 are strongly associated with Paget's disease of bone (PDB), but little is known about the clinical characteristics of those with early disease. Radionuclide bone scans, biochemical markers of bone turnover, and clinical characteristics were analyzed in SQSTM1 mutation carriers who took part in the Zoledronic acid in the Prevention of Paget's disease (ZiPP) study. We studied 222 individuals, of whom 54.9% were female, with mean ± SE age of 50.1 ± 0.6 years. Twelve SQSTM1 mutations were observed, including p.Pro392Leu, which was present in 141 of 222 (63.5%) subjects. Bone scan examination revealed evidence of PDB in 20 subjects (9.0%), ten of whom (50%) had a single affected site. Participants with lesions were older than those without lesions but the difference was not significant (53.6 ± 9.1 versus 49.8 ± 8.9; p =.07). The mean age of participants with lesions was not significantly different from the age at which their parents were diagnosed with PDB (55 years versus 59 years, p =.17). All individuals with lesions were asymptomatic. Serum concentrations of total alkaline phosphatase (ALP) normalized to the upper limit of normal in each center were higher in those with lesions (0.75 ± 0.69 versus 0.42 ± 0.29 arbitary units; p <.0001). Similar findings were observed for other biochemical markers of bone turnover, but the sensitivity of ALP and other markers in detecting lesions was poor. Asymptomatic PDB is present in about 9% of SQSTM1 mutation carriers by the fifth decade. Further follow-up of this cohort will provide important information on the natural history of early PDB and its response to treatment.

Published
2020

19. Characteristics of Early Paget's Disease in SQSTM1 Mutation Carriers: Baseline Analysis of the ZiPP Study Cohort.

Author

UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, Cronin, Owen, Subedi, Deepak, Forsyth, Laura, Goodman, Kirsteen, Lewis, Steff C, Keerie, Catriona, Walker, Allan, Porteous, Mary, Cetnarskyj, Roseanne, Ranganath, Lakshminarayan R, Selby, Peter L, Hampson, Geeta, Chandra, Rama, Ho, Shu, Tobias, Jon H, Young-Min, Steven A, McKenna, Malachi J, Crowley, Rachel K, Fraser, William D, Tang, Jonathan, Gennari, Luigi, Nuti, Rannuccio, Brandi, Maria-Luisa, Del Pino-Montes, Javier, Devogelaer, Jean-Pierre, Durnez, Anne, Isaia, Giovanni Carlo, Di Stefano, Marco, Rubio, Josep Blanch, Guanabens, Nuria, Seibel, Markus J, Walsh, John P, Kotowicz, Mark A, Nicholson, Geoffrey C, Duncan, Emma L, Major, Gabor, Horne, Anne, Gilchrist, Nigel L, Ralston, Stuart H, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, Cronin, Owen, Subedi, Deepak, Forsyth, Laura, Goodman, Kirsteen, Lewis, Steff C, Keerie, Catriona, Walker, Allan, Porteous, Mary, Cetnarskyj, Roseanne, Ranganath, Lakshminarayan R, Selby, Peter L, Hampson, Geeta, Chandra, Rama, Ho, Shu, Tobias, Jon H, Young-Min, Steven A, McKenna, Malachi J, Crowley, Rachel K, Fraser, William D, Tang, Jonathan, Gennari, Luigi, Nuti, Rannuccio, Brandi, Maria-Luisa, Del Pino-Montes, Javier, Devogelaer, Jean-Pierre, Durnez, Anne, Isaia, Giovanni Carlo, Di Stefano, Marco, Rubio, Josep Blanch, Guanabens, Nuria, Seibel, Markus J, Walsh, John P, Kotowicz, Mark A, Nicholson, Geoffrey C, Duncan, Emma L, Major, Gabor, Horne, Anne, Gilchrist, Nigel L, and Ralston, Stuart H

Abstract

Mutations in SQSTM1 are strongly associated with Paget's disease of bone (PDB), but little is known about the clinical characteristics of those with early disease. Radionuclide bone scans, biochemical markers of bone turnover, and clinical characteristics were analyzed in SQSTM1 mutation carriers who took part in the Zoledronic acid in the Prevention of Paget's disease (ZiPP) study. We studied 222 individuals, of whom 54.9% were female, with mean ± SE age of 50.1 ± 0.6 years. Twelve SQSTM1 mutations were observed, including p.Pro392Leu, which was present in 141 of 222 (63.5%) subjects. Bone scan examination revealed evidence of PDB in 20 subjects (9.0%), ten of whom (50%) had a single affected site. Participants with lesions were older than those without lesions but the difference was not significant (53.6 ± 9.1 versus 49.8 ± 8.9; p = .07). The mean age of participants with lesions was not significantly different from the age at which their parents were diagnosed with PDB (55 years versus 59 years, p = .17). All individuals with lesions were asymptomatic. Serum concentrations of total alkaline phosphatase (ALP) normalized to the upper limit of normal in each center were higher in those with lesions (0.75 ± 0.69 versus 0.42 ± 0.29 arbitary units; p < .0001). Similar findings were observed for other biochemical markers of bone turnover, but the sensitivity of ALP and other markers in detecting lesions was poor. Asymptomatic PDB is present in about 9% of SQSTM1 mutation carriers by the fifth decade. Further follow-up of this cohort will provide important information on the natural history of early PDB and its response to treatment. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.

Published
2020

20. The effects of sustained fitness improvement on the gut microbiome: A longitudinal, repeated measures case‐study approach

Author

Barton, Wiley, primary, Cronin, Owen, additional, Garcia‐Perez, Isabel, additional, Whiston, Ronan, additional, Holmes, Elaine, additional, Woods, Trevor, additional, Molloy, Catherine B., additional, Molloy, Michael G., additional, Shanahan, Fergus, additional, Cotter, Paul D., additional, and O’Sullivan, Orla, additional

Published
2020
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22. Characteristics of Early Paget's Disease inSQSTM1Mutation Carriers: Baseline Analysis of theZiPPStudy Cohort

Author

Cronin, Owen, primary, Subedi, Deepak, additional, Forsyth, Laura, additional, Goodman, Kirsteen, additional, Lewis, Steff C, additional, Keerie, Catriona, additional, Walker, Allan, additional, Porteous, Mary, additional, Cetnarskyj, Roseanne, additional, Ranganath, Lakshminarayan R, additional, Selby, Peter L, additional, Hampson, Geeta, additional, Chandra, Rama, additional, Ho, Shu, additional, Tobias, Jon H, additional, Young‐Min, Steven A, additional, McKenna, Malachi J, additional, Crowley, Rachel K, additional, Fraser, William D, additional, Tang, Jonathan, additional, Gennari, Luigi, additional, Nuti, Rannuccio, additional, Brandi, Maria‐Luisa, additional, Pino‐Montes, Javier, additional, Devogelaer, Jean‐Pierre, additional, Durnez, Anne, additional, Isaia, Giovanni Carlo, additional, Di Stefano, Marco, additional, Rubio, Josep Blanch, additional, Guanabens, Nuria, additional, Seibel, Markus J, additional, Walsh, John P, additional, Kotowicz, Mark A, additional, Nicholson, Geoffrey C, additional, Duncan, Emma L, additional, Major, Gabor, additional, Horne, Anne, additional, Gilchrist, Nigel L, additional, and Ralston, Stuart H, additional

Published
2020
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24. Additional file 3: of Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial

Author

Cronin, Owen, Barton, Wiley, Carthage Moran, Sheehan, Donal, Whiston, Ronan, Nugent, Helena, McCarthy, Yvonne, Molloy, Catherine, O’Sullivan, Orla, Cotter, Paul, Molloy, Michael, and Shanahan, Fergus

Subjects
respiratory system, human activities
Abstract

Figure S2. Îą-diversity of metabolic pathways. A to D: Shannon Îą-diversity H-index of general and species specific metabolic pathways at week 0 (pre) and week 8 (post). (DOCX 193 kb)

Published
2019
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25. Additional file 2: of Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial

Author

Cronin, Owen, Barton, Wiley, Carthage Moran, Sheehan, Donal, Whiston, Ronan, Nugent, Helena, McCarthy, Yvonne, Molloy, Catherine, O’Sullivan, Orla, Cotter, Paul, Molloy, Michael, and Shanahan, Fergus

Abstract

Figure S1. β-diversity of taxonomic profiles. A & B: Non-metric multidimensional scaling (NMDS) of relative abundance profiles for Bacteria species. C & D: Principal-coordinate analysis (PCoA) of Archaea relative abundance. (DOCX 626 kb)

Published
2019
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27. Zoledronate in the prevention of Paget’s (ZiPP): protocol for a randomised trial of genetic testing and targeted zoledronic acid therapy to preventSQSTM1-mediated Paget’s disease of bone

Author

Cronin, Owen, primary, Forsyth, Laura, additional, Goodman, Kirsteen, additional, Lewis, Steff C, additional, Keerie, Catriona, additional, Walker, Allan, additional, Porteous, Mary, additional, Cetnarskyj, Roseanne, additional, Ranganath, Lakshminarayan R, additional, Selby, Peter L, additional, Hampson, Geeta, additional, Chandra, Rama, additional, Ho, Shu, additional, Tobias, Jon H, additional, Young-Min, Steven, additional, McKenna, Malachi J, additional, Crowley, Rachel K, additional, Fraser, William D, additional, Gennari, Luigi, additional, Nuti, Ranuccio, additional, Brandi, Maria Luisa, additional, Del Pino-Montes, Javier, additional, Devogelaer, Jean-Pierre, additional, Durnez, Anne, additional, Isaia, Giancarlo, additional, Di Stefano, Marco, additional, Guañabens, Núria, additional, Blanch, Josep, additional, Seibel, Markus J, additional, Walsh, John P, additional, Kotowicz, Mark A, additional, Nicholson, Geoffrey C, additional, Duncan, Emma L, additional, Major, Gabor, additional, Horne, Anne, additional, Gilchrist, Nigel L, additional, Boers, Maarten, additional, Murray, Gordon D, additional, Charnock, Keith, additional, Wilkinson, Diana, additional, Russell, R Graham G, additional, and Ralston, Stuart H, additional

Published
2019
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33. A Prospective Metagenomic and Metabolomic Analysis of the Impact of Exercise and/or Whey Protein Supplementation on the Gut Microbiome of Sedentary Adults

Author

Cronin, Owen, primary, Barton, Wiley, additional, Skuse, Peter, additional, Penney, Nicholas C., additional, Garcia-Perez, Isabel, additional, Murphy, Eileen F., additional, Woods, Trevor, additional, Nugent, Helena, additional, Fanning, Aine, additional, Melgar, Silvia, additional, Falvey, Eanna C., additional, Holmes, Elaine, additional, Cotter, Paul D., additional, O’Sullivan, Orla, additional, Molloy, Michael G., additional, and Shanahan, Fergus, additional

Published
2018
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41. The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level.

Author

Barton, Wiley, Penney, Nicholas C., Cronin, Owen, Garcia-Perez, Isabel, Molloy, Michael G., Holmes, Elaine, Shanahan, Fergus, Cotter, Paul D., and O'Sullivan, Orla

Subjects
PROFESSIONAL athletes, SEDENTARY behavior, CARBOHYDRATE metabolism, GUT microbiome, EXERCISE physiology, MICROBIAL metabolites, HEALTH
Published
2018
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42. Impact of short-term cycle ergometer training on quality of life, cognition and depressive symptomatology in multiple sclerosis patients: a pilot study.

Author

Barry, Alison, Cronin, Owen, Ryan, Aisling M, Sweeney, Brian, O'Toole, Orna, Allen, Andrew P, Clarke, Gerard, O'Halloran, Ken D, and Downer, Eric J

Subjects
*EXERCISE & psychology, *EXERCISE therapy, *IMMUNOLOGICAL adjuvants, *MENTAL health, *MULTIPLE sclerosis treatment, *BODY weight, *COGNITION, *MENTAL depression, *NEUROPSYCHOLOGICAL tests, *MULTIPLE sclerosis, *PHYSICAL fitness, *QUALITY of life, *QUESTIONNAIRES, *PILOT projects, *BODY mass index, *TREATMENT effectiveness, *EQUIPMENT & supplies, *THERAPEUTICS
Abstract

In this pilot study, we investigate whether a routine cycle ergometry training programme has therapeutic potential in individuals with multiple sclerosis (MS) by improving quality of life (QOL) and depressive symptomatology, while ameliorating cognitive disturbances. Healthy volunteers and MS patients cycled for 30 min at 65-75% age-predicted maximal heart rate on a recumbent ergometer, with this session repeated twice a week for 8 weeks. QOL, depressive symptomatology and cognitive function were assessed pre- and post-exercise using the MS Quality of Life-54 (MSQOL-54) questionnaire, 16-item Quick Inventory of Depressive Symptomatology (QIDS-SR16) questionnaire and the Cambridge Neuropsychological Test Automated Battery (CANTAB), respectively. We determined that QOL was lower in MS patients, compared to healthy subjects, with a reduction in physical and mental health summary scores observed. Exercise improved both physical and mental health scores in MS patients. In support of this, exercise was shown to reduce depressive symptomatology in MS patients. Exercise was also associated with an improvement in visual sustained attention, executive function/cognitive flexibility and hippocampal-dependent visuospatial memory in patients. Overall, this study identifies a short-term exercise programme that improves physical and mental health, while reducing depressive symptomatology and cognitive dysfunction in MS. [ABSTRACT FROM AUTHOR]

Published
2018
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43. Exercise and the microbiota

Author

O’Sullivan, Orla, primary, Cronin, Owen, additional, Clarke, Siobhan F, additional, Murphy, Eileen F, additional, Molloy, Micheal G, additional, Shanahan, Fergus, additional, and Cotter, Paul D, additional

Published
2015
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44. Ultrasound in the diagnosis and monitoring of eosinophilic fasciitis.

Author

Eong, Denise T M Au, Cronin, Owen, Biswas, Asok, and McKay, Neil D

Subjects
*EOSINOPHILS, *ALBUMINS, *FASCIITIS, *POINT-of-care testing, *CREATINE kinase, *EOSINOPHILIA
Abstract

In the article, the authors present a case of a 43-year-old man who was rushed to a clinic due to 5-month history of progressive bilateral forearm and calf muscle pain and tightness, as well as fatigue to discuss the successful use of ultrasound in diagnosing and monitoring a patient with eosinophilic fasciitis (EF) or Shulman's syndrome. Also cited are the associated abnormalities of EF like hypergammaglobulinaemia and peripheral blood eosinophilia.

Published
2021
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45. Multiple myeloma presenting as mandibular pain.

Author

Crowley, Miriam, Cronin, Owen, Sleeman, Duncan, and McKenna, Joe

Subjects
ORAL surgery, MULTIPLE myeloma, PLASMA cells, MONOCLONAL antibodies, IMMUNOGLOBULINS
Abstract

Introduction: Multiple myeloma (MM) is a systemic malignancy of plasma cells defined by monoclonal production of circulating immunoglobulins. Bone pain is a presenting feature in the majority of cases. Treatment may involve intravenous use of bisphosphonates, chemotherapy or haematopoietic stem cell transplantation. Here, we illustrate a first presentation of MM in a patient with mandibular pain and discuss radiographic, diagnostic and treatment challenges of orofacial issues in patients with MM.Case Report: A 69-year-old lady presented to an emergency oral surgery clinic with a month-long history of unilateral left-sided pain in her jaw. Examination revealed a buccolingual swelling of 2cm diameter in the lower left premolar region. Radiographic images demonstrated a 2cm lytic lesion in her mandible corresponding with the symptomatic region. Aspiration of the lesion was performed and histological analysis indicated an abundance of atypical plasma cells. Subsequent biopsy revealed sheets of plasmacytoid cells suggesting evidence of a plasmacytoma. Skeletal survey, bone marrow biopsy and serum analysis confirmed the presence of MM.Discussion: MM, although a systemic malignancy, can present via a variety of orofacial manifestations. The presence of a lytic lesion on plain radiographs should alert the dental practitioner to the possibility of the diagnosis. Treatment of orofacial bone pain may respond to intravenous bisphosphonates but care must be taken to avoid osteonecrosis of the jaw.Conclusion: This case is an important reminder of the potential oral presentations of MM and underlines the importance of radiographic evaluation in patients with atypical symptoms and presentations. [ABSTRACT FROM AUTHOR]

Published
2016

47. Additional file 4: of Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial

Author

Cronin, Owen, Barton, Wiley, Carthage Moran, Sheehan, Donal, Whiston, Ronan, Nugent, Helena, McCarthy, Yvonne, Molloy, Catherine, O’Sullivan, Orla, Cotter, Paul, Molloy, Michael, and Shanahan, Fergus

Subjects
3. Good health
Abstract

Figure S3. β-diversity of metabolic pathways. (DOCX 581 kb)

48. Additional file 4: of Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial

Author

Cronin, Owen, Barton, Wiley, Carthage Moran, Sheehan, Donal, Whiston, Ronan, Nugent, Helena, McCarthy, Yvonne, Molloy, Catherine, O’Sullivan, Orla, Cotter, Paul, Molloy, Michael, and Shanahan, Fergus

Subjects
3. Good health
Abstract

Figure S3. β-diversity of metabolic pathways. (DOCX 581 kb)

49. Additional file 1: of Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial

Author

Cronin, Owen, Barton, Wiley, Carthage Moran, Sheehan, Donal, Whiston, Ronan, Nugent, Helena, McCarthy, Yvonne, Molloy, Catherine, O’Sullivan, Orla, Cotter, Paul, Molloy, Michael, and Shanahan, Fergus

Subjects
3. Good health
Abstract

Table S1. Pre- and post-intervention values for resting inflammatory biomarkers in the exercise and control groups. (DOCX 16 kb)

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