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Resumo A Educação Interprofissional em Saúde (EIP) constitui-se como uma estratégia para formação de profissionais capazes de trabalhar em equipe por meio de competências colaborativas e da aprendizagem baseada em interações. O Projeto Pedagógico da Universidade Federal de São Paulo (Unifesp) baseia-se nos princípios da EIP para a formação de profissionais, dentre eles, terapeutas ocupacionais. Objetivou-se compreender a influência da formação interprofissional na trajetória profissional de terapeutas ocupacionais egressas da Unifesp. Pela abordagem qualitativa, produziram-se informações por aplicação de formulário on-line semiestruturado, analisado posteriormente com base na Análise Temática. Os resultados revelaram que a formação interprofissional possibilita segurança às profissionais nas práticas colaborativas, no fomento ao trabalho em equipe e no desenvolvimento de ações que visam à integralidade do cuidado. Notou-se, porém, dificuldades no reconhecimento da identidade profissional da Terapia Ocupacional e na ação conjunta com profissionais formados em perspectiva disciplinar. Abstract Interprofessional education in healthcare (IEH) is a strategy to prepare professionals who are capable of working in a team by developing interactive-based collaboration and learning competencies. The Federal University of Sao Paulo’s (UNIFESP) education plan is based on the principles of IEH for professional training. The aim of this study was to understand the influence of interprofessional education on the career trajectory of occupational therapy students graduating from UNIFESP. Adopting a qualitative approach, data was collected using an online semi-structured questionnaire and analyzed using thematic analysis. The results show that interprofessional education helped professionals feel secure when engaging in collaborative practice and fostered teamwork and the development of actions aimed at promoting comprehensive care. However, the findings also highlight challenges related to the recognition of the professional identity of occupational therapists and in working together with professionals trained from a uniquely disciplinary perspective. Resumen La Educación Interprofesional en Salud (EIP) se constituye como una estrategia para la formación de profesionales capaces de trabajar en equipo, por medio de competencias colaborativas y del aprendizaje basado en interacciones. El Proyecto Pedagógico de la Universidad Federal de São Paulo (Unifesp), se basa en los principios de la EIP para la formación de profesionales, entre ellos, terapeutas ocupacionales. El objetivo fue entender la influencia de la formación interprofesional en la trayectoria profesional de terapeutas ocupacionales egresadas de Unifesp. A partir del abordaje cualitativo, se produjeron informaciones por medio de la utilización de un formulario online semiestructurado, analizado posteriormente con base en el Análisis Temático. Los resultados señalaron que la formación interprofesional posibilita seguridad a las profesionales en las prácticas colaborativas, fomento al trabajo en equipo y desarrollo de acciones cuyo objetivo es la integralidad del cuidado. No obstante, se observaron dificultades en el reconocimiento de la identidad profesional de la Terapia Ocupacional y en la acción conjunta con profesionales formados en perspectiva disciplinaria.

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Absolute values and statistics for quantitative acylcarnitine data. Absolute values and statistics for quantitative GSH and GSSG data.

1. Cytosolic lipid storage is decreased in RCC tissue with increasing tumor grade 2. Glutamine depletion attenuates RCC cell viability, decreases the anti-oxidant system, and results in evidence of increased oxidative stress

The hydrological regime leads to fluctuations in the availability of food resources for fish, which may reflect in their diet variation. Our main goal was to analyze the relationship between water-level fluctuations and the diet and the body condition of Trachelyopterus galeatus in the Upper Paraná River floodplain. The fish used in the study were sampled quarterly along nine years, at nine sampling stations. Our results showed that diet of T. galeatus varied in response to oscillations in the hydrometric level, with the consumption of terrestrial invertebrates being positively related to hydrometric level, while the consumption of aquatic invertebrates was negatively related. The trophic niche breadth and feeding activity were not affected by hydrometric level, but the fish body condition was positively affected. The high food plasticity allows T. galeatus to consume the most available resources (e.g., terrestrial invertebrates in high water levels), which probably contributed to the increase in its body condition in higher hydrometric levels. In summary, the hydrological dynamic is fundamental for the diet variation of omnivorous fish, which can take advantage of the resource availability according to the hydrometric level, increasing its body condition when allochthonous resources as terrestrial invertebrates are supposed to be more available. Resumo O regime hidrológico leva a flutuações na disponibilidade de recursos alimentares para os peixes, o que pode refletir na variação de sua dieta. O principal objetivo foi analisar a relação entre as oscilações do nível hidrométrico e a dieta e condição corporal de Trachelyopterus galeatus na planície de inundação do alto rio Paraná. Os peixes foram amostrados trimestralmente durante nove anos, em nove locais. Nossos resultados mostraram que a dieta de T. galeatus variou em resposta às oscilações do nível hidrométrico, com o consumo de invertebrados terrestres sendo positivamente relacionado com o nível hidrométrico, enquanto o consumo de invertebrados aquáticos foi negativamente relacionado. O nicho trófico e a atividade alimentar não foram afetados pelo nível hidrométrico, mas a condição corporal dos peixes foi positivamente afetada. A alta plasticidade alimentar permite que T. galeatus aproveite recursos mais disponíveis (por exemplo, invertebrados terrestres em níveis elevados), o que provavelmente contribui para o aumento da condição corporal em níveis hidrométricos elevados. Em resumo, a dinâmica hidrológica é fundamental para a variação da dieta de peixes onívoros, que podem aproveitar a disponibilidade de recursos de acordo com o nível hidrométrico, aumentando sua condição corporal quando recursos alóctones, como invertebrados terrestres, são supostamente mais disponíveis.

This paper presents the challenges of production and dissemination of knowledge in Occupational Therapy in Latin America, its place in the global scenario and the weaving of a political-epistemic network of communication, discussion and exchange. A sense of groupwork, processes and intervention as a collective network is proposed to analyse and understand the social relational practices that make up the political-epistemic network between key-subjects, different types of knowledge, as well as different ways of producing and disseminating them for the institutionality of the field of Occupational Therapy itself and for its outreach in society in general. To this end, we describe and analyse the actions of the Amaru Network as a collective strategy to face the challenges of the production and dissemination of hegemonic and excluding knowledge in Occupational Therapy in the Latin American context. We take as the axis of analysis the idea of collective as a conceptual category that serves to designate and guide the counter-hegemonic processes of knowledge production in the scientific and cosmological reality of the Latin American region. The Amaru Network, in proposing and sustaining a social practice engendered in a collaborative network between Latin American countries, turns its gaze to the broadening of epistemological bases for other possible modes of knowledge production. Este ensaio apresenta os desafios da produção e difusão de conhecimento em Terapia Ocupacional na América Latina, seu lugar no cenário global e a tessitura de uma rede político-epistêmica de comunicação, de discussão e troca. Propõe-se um sentido de trabalho em grupo, de processos e intervenção, enquanto coletivo em rede para analisar e compreender as práticas sociais relacionais que conformam a rede político-epistêmica entre sujeitos-chaves, diferentes tipos de conhecimento, bem como distintos modos de produzi-los e difundi-los para a institucionalidade da própria área de Terapia Ocupacional e para seu alcance na sociedade em geral. Para tanto, são descritas e analisadas ações da Rede Amaru como estratégia coletiva no enfrentamento aos desafios da produção e difusão do conhecimento hegemônico e excludente em Terapia Ocupacional que se colocam ao contexto latino-americano. Tomamos como eixo de análise a ideia de coletivo enquanto uma categoria conceitual que serve para designar e orientar os processos contra-hegemônicos da produção de conhecimento na realidade científica e cosmológica da região latino-americana. A Rede Amaru, ao se propor e sustentar uma prática social engendrada em uma rede colaborativa entre países latino-americanos, volta seu olhar para o alargamento das bases epistemológicas para outros modos possíveis de produção de conhecimento

Clear cell Renal Cell Carcinoma (ccRCC) is the most common and metastatic urological cancer. Molecular players of ccRCC progression and metastasis are not completely known. Here, using primary cell cultures from patients' specimens, we found that TGFβ1/Smad signalling is more activated in high versus low grade ccRCC and inversely correlates with Abl2 tyrosine kinase protein expression. TGFβ1 treatment increased ubiquitination and degradation of Abl2 protein in ccRCC cell lines by TGFβ1/Smad pathway activation and reactive oxygen species production. 3D invasion and matrix degradation assays showed that Abl2 promoted TGFβ1-induced ccRCC cell invasion and maturation of invadopodia, a hallmark of tumour invasion and metastasis. Our findings define Abl2 as a new downstream molecule of TGFβ1 signalling and putative target to counteract advanced ccRCC.

O presente capítulo de livro tem como objetivo apresentar os aspectos do abandono afetivo nas relações familiares frente ao ordenamento jurídico. A afetividade ganhou relevância na família contemporânea, destacando-se na legislação brasileira de forma principiológica. Em virtude disso, a legislação impõe, por exemplo, aos pais deveres na relação com seus filhos, como assistir, cuidar, educar e participar de seu desenvolvimento, e em caso de descumprimento, será imputada aos genitores a devida responsabilização pelo dano cometido. A discussão do tema implica na valoração do afeto no cenário jurídico, visto a crescente demanda pela reparação dos prejuízos morais. Como resultado, aponta-se que o dano causado ao descendente pode ser imensurável, todavia, a imputação da responsabilidade civil cumprirá sua função social e trará segurança jurídica na consagração do direito positivo. Nesse sentido, conclui-se que a reparação moral não será em relação ao amor que o genitor demonstra, mas sobre o descumprimento do dever legal de cuidado com a prole. Como metodologia, utilizou-se o método dedutivo, pesquisa bibliográfica, entendimento dos Tribunais, sítios da web, bem como em legislações pátrias.

To evaluate the impact of adding a glucagon-like peptide-1 receptor agonist (GLP-1 RA) in people with type 2 diabetes (T2D) in basal-bolus (BB) insulin regimen, on insulin requirement, HbA1c, weight loss up to 24 months.Data on subjects with T2D on BB who initiated a GLP-1 RA have been retrospectively collected. HbA1c, body weight, and insulin dose were recorded at baseline, 6, 12, and 24 months after initiation of GLP-1 RA therapy. A linear mixed model for repeated measures was used to evaluate the changes in HbA1c, body weight, and insulin requirement over time.We included 156 subjects (63.5% males; age 62 ± 11 years, HbA1c 70 ± 22.0 mmol/mol; 8.6 ± 4.2%). Compared to baseline, HbA1c and body weight were significantly lower at 6 months after introducing a GLP-1RA and remained stable up to 24 months (all p 0.0001 vs. baseline). At 24 months, 81% of subjects discontinued prandial insulin, while 38.6% discontinued basal insulin as well. Insulin requirement at baseline (aOR 0.144; 95% CI, 0.046-0.456; P = 0.001) was the only significant predictor of prandial insulin discontinuation.Replacing prandial insulin with GLP-1 RA is a valuable strategy to simplify the BB insulin regimen while improving glycaemic control and promoting weight loss in subjects with T2D.

Since it is unknown whether glucose variability (GV) is increased and whether this is related to worsening of insulin secretion and action in prediabetes, we have assessed insulin secretion and sensitivity, and daily GV in early stages of dysglycemia.Twenty subjects with normal glucose tolerance (NGT; age 45.0 ± 9.5 years; BMI 31.1 ± 6.4 kg/m2), 25 with NGT and 1hrOGTT8.6 mmol/L (1hrOGTT; 45.7 ± 8.5 years; 32.4 ± 7.0 kg/m2), and 59 with isolated impaired glucose tolerance (iIGT; 47.7 ± 11.2 years; 31.3 ± 6.1 kg/m2) underwent OGTT and MMTT. CGM was performed with blinded FreeStyle Libre Pro for 24 h under standard conditions. Parameters of beta-cell function, insulin sensitivity and GV were calculated.Overall insulin secretion and action as well as GV progressively worsened across glucose tolerance categories. On a matrix analysis, GV parameters were inversely related to ISSI-2; r = -0.37 to -0.52; p 0.0001; and IGI; r = -0.28 to -0.48; p 0.0001 for CV, SD, J-index, LI, HBGI and MAGE. Insulin secretion (IGI) and b-cell function (ISSI-2) emerged as independent contributors to GV in early stage of dysglycemia accounting for about 16%-38% of its variability.Our results show that daily GV worsens already with mild impairment of glucose tolerance. The increase in GV is inversely related to insulin secretion and action.

The termsTo understand the formation of the concepts ofA conceptual review of the specific literature in journals, databases and books published in Latin America between 1990 and July 2020. The two most frequently recurring authors of publications in each country were interviewed.74 publications were selected. The first definitions of these concepts date from the late 1990s. Dialogue with other areas of knowledge began in 2002.Although the terms are conceptually little developed, their use in occupational therapy in Latin America evidences the understanding that the singularity of people and groups is inseparable from their social history.Occupational therapy in Latin America has appropriated notions of

Aims As recommended by the Institute of Medicine (IOM), health practitioners should encourage a healthy nutrition and adequate weight gain during pregnancy in order to ensure favorable pregnancy and fetal outcomes, and to prevent diseases later in life for both mother and child. The purpose of this online survey was to determine the knowledge, attitude, and practice of the 2009 IOM recommendations among healthcare professionals managing nutritional therapy in pregnancies complicated by diabetes in Italy. Methods A cross-sectional survey was conducted by using an online self-administered questionnaire undertaken between October and December 2021. Results Of the 220 participants 89% were diabetologists/endocrinologists/internal medicine specialists and 11% dietitians/nutritionists. The survey found that the 53% of respondents provide a personalized diet to pregnant women with diabetes, while 32% a standard diet plan and only 15% healthy dietary advice. The 69% of the participants investigated for appropriate gestational weight gain, mainly based on pre-pregnancy BMI (96%), gestational weight gain (GWG) at first prenatal visit (80%) and presence of twin pregnancy (58%). Maternal weight gain was evaluated at each regularly scheduled prenatal visit and compared with IOM recommendations for the 87% of healthcare professionals. Diet plan was periodically re-evaluated and/or modified (90% of participants), based on inadequate maternal weight gain and/or fetal growth abnormalities (78%), trimester transition (53%), changes in physical activity and/or a “feel hungry” (50%). Conclusions This survey reported the knowledge and attitude of IOM guidelines and the nutritional knowledge and practice of Italian professionals on the nutritional management of diabetes in pregnancy. The application of these recommendations seemed more feasible in clinics/team dedicated to "Diabetes in Pregnancy".

The discovery of insulin in 1921 – due to the efforts of the Canadian research team based in Toronto – has been a landmark achievement in the history of medicine. Lives of people with diabetes were changed forever, considering that in the pre-insulin era this was a deadly condition. Insulin, right after its discovery, became the first hormone to be purified for human use, the first to be unraveled in its amino acid sequence and to be synthetized by DNA-recombinant technique, the first to be modified in its amino acid sequence to modify its duration of action. As such the discovery of insulin represents a pivotal point in medical history. Since the early days of its production, insulin has been improved in its pharmacokinetic and pharmacodynamic properties in the attempt to faithfully reproduce diurnal physiologic plasma insulin fluctuations. The evolution of insulin molecule has been paralleled by evolution in the way the hormone is administered. Once-weekly insulins will be available soon, and glucose-responsive “smart” insulins start showing their potential in early clinical studies. The first century of insulin as therapy was marked by relentless search for better formulations, a search that has not stopped yet. New technologies may have, indeed, the potential to provide further improvement of safety and efficacy of insulin therapy and, therefore, contribute to improvement of the quality of life of people with diabetes.

Os processos educativos têm exigido e possibilitado delinear e vivenciar experiências de formação e cuidado em resposta aos efeitos da atual pandemia. Em consonância com essa afirmação, o presente trabalho tem por objetivo relatar uma experiência formativa com estudantes do curso de Terapia Ocupacional de uma universidade pública durante a pandemia de Covid-19. A experiência foi analisada em dois momentos, nomeados no relato como “Respiros”. No primeiro momento, em ambiente virtual, foram realizadas rodas de conversa-mosaico sem a presença obrigatória das estudantes; no segundo momento, como um módulo opcional no currículo, foram introduzidas práticas artísticas e corporais como dispositivos para o cuidado, expressão e conexão entre os corpos. As estudantes indicaram a importância de se criar um ambiente confiável e de sustentarmos uma proposta coletiva, dando ensejo à construção de corpos sensíveis, inventivos e críticos, fundamentais no exercício profissional.

Frailty is an age-related syndrome that exposes individuals to increased vulnerability. Although it is potentially reversible, in most cases it leads to negative outcomes, including mortality. The different methods proposed identify frailty after the onset of clinical manifestations. An early diagnosis might make it possible to manage the frailty progression better. The frailty pathophysiology is still unclear although mechanisms, in particular, those linked to inflammation and immunosenescence, have been investigated. A common feature of several clinical aspects involved in senescent organisms is the increase of oxidative stress, described as one of the major causes of deoxyribonucleic acid (DNA) damage accumulation in aged cells including the adult stem cell compartment. Likely, this accumulation is implicated in frailty status. The oxidative status of our frail, pre-frail, and non-frail population was characterized. In addition, the DNA damage in hematopoietic cells was evidenced by analyzing the peripheral blood mononuclear cell and their T lymphocyte, monocyte, circulating hematopoietic progenitor stem cell (cHPSC) subpopulations. The phosphorylation of C-terminal of histone H2AX at amino acid Ser 139 (γ-H2AX), which occurs at the DNA double-strand break focus, was evaluated. In our frail population, increased oxidative stress and a high level of DNA damage in cHPSC were found. This study may have potential implications because the increment of DNA damage in cHPSC could be suggestive of an organism impairment preceding the evident frailty. In addition, it may open the possibility for attenuation of frailty progression throughout specific drugs acting on preventing DNA damage or removing damaged cells

MG53 is a myokine modulating insulin signaling in several tissues; its relationship to glucose tolerance or risk of developing type 2 diabetes mellitus (T2DM) is unknown. This observational, prospective study aimed at evaluating the relationship between MG53 and glucose tolerance, testing whether its circulating levels may be associated with disease progression in a cohort at high risk of T2DM.Five hundred and fifteen subjects who underwent a deep characterization of their glucose tolerance in the years 2003-2005 participated in this study. MG53 levels were measured at baseline. Glucose tolerance status was available over a follow-up of 15 ± 2 years for 283 of them; their vital status as of December 2020 was also retrieved.MG53 levels were significantly lower in subjects with normal glucose tolerance than in subjects with impaired glucose regulation (IGR) or T2DM. Individuals in the highest MG53 levels quartile had more frequently 1h-post load glucose ≥ 155 mg/dL (54% vs 39%; p = 0.015), worse proportional control of β-cell function (p 0.05-0.01), as determined by mathematical modeling, and worse Disposition Index (DI) (0.0155 ± 0.0081 vs 0.0277 ± 0.0030; p 0.0001). At follow-up, baseline MG53 levels were higher in progressors than in non-progressors (120.1 ± 76.7 vs 72.7 ± 63.2 pg/ml; p = 0.001; ROC curve area for incident diabetes of 0.704). In a multivariable regression with classic risk factors for T2DM and DI, MG53 remained independently associated with progression with T2DM.MG53 may be a novel biomarker of glucose dysregulation associated with β-cell dysfunction, likely improving our ability to identify, among high-risk subjects, those more likely to develop T2DM.

In spite of being at target for glucose (1) or traditional cardiovascular (CV) risk factors (2), individuals with type 1 diabetes (T1D) still have an excess of CV mortality and morbidity implying a role for other mechanisms including insulin resistance (IR). Impaired insulin action in T1D was established by clamp technique long ago (3). Estimated glucose disposal rate (eGDR) correlates well with the clamp technique (4) and is a risk marker for microangiopathy (5,6), diabetic kidney disease (DKD) (6), CV risk, and mortality (5,7). In this observational single-center study, we investigated to what extent eGDR is a predictor of CV events, coronary artery disease (CAD), and all-cause mortality irrespective of CV risk factors and DKD in 774 subjects with T1D over a 10-year follow-up, as previously described (8). eGDR (mg/kg/min) was calculated at baseline as follows (4): eGDR = 21.158 − (0.09 × WC) − (3.407 × HTN) − (0.551 × HbA1c), where WC is waist circumference (cm), HTN is hypertension (yes = 1, no = 0), and HbA1c is in %. Follow-up data were retrieved from the national and regional health care registers (ICD-9, Clinical Modification, codes) by searching for CV outcomes (primary outcome) up to 31 December 2017 and for all-cause death up to 31 October 2018. Incidence of CV outcomes was available for 736 participants (95.1%), and vital status was available for all individuals (8). We used univariate and multivariate Cox proportional hazards models to …

Background and aims Screening for Gestational Diabetes (GDM) is usually recommended between 24 and 28 weeks of pregnancy; however available evidence suggests that GDM may be already present before recommended time for screening, in particular among high-risk women as those with prior GDM or obesity. The purpose of this retrospective study was to evaluate whether early screening (16–18 weeks) and treatment of GDM may improve maternal and fetal outcomes. Methods and results In 290 women at high-risk for GDM, we analyzed maternal and fetal outcomes, according to early or standard screening and GDM diagnosis time. Early screening was performed by 50% of high-risk women. The prevalence of GDM was 62%. Among those who underwent early screened, GDM was diagnosed at the first evaluation in 42.7%. Women with early diagnosis were more frequently treated with insulin and had a slightly lower HbA1c than women with who were diagnosed late. No differences were observed in the prevalence of Cesarean section, operative delivery, gestational age at the delivery, macrosomia, neonatal weight, Ponderal Index and Large-for-Gestational-Age among women with early or late GDM diagnosis or NGT. However, compared to NGT women, GDM women, irrespective of the time of diagnosis, had a lower gestational weight gain, lower prevalence of macrosomia (3.9% vs. 11.4%), small (1.7% vs. 8.3%) as well as large for gestational age (3.3% vs. 16.7%), but higher prevalence of pre-term delivery (8.9% vs. 2.7%). Conclusion Early vs. standard screening and treatment of GDM in high-risk women is associated with similar short-term maternal-fetal outcomes, although women with an early diagnosis were treated to a greater extent with insulin therapy.

El artículo aborda el desarrollo teórico-práctico de los conceptos territorio y comunidad en la Terapia Ocupacional colombiana. El objetivo fue comprender el uso y la elaboración de tales conceptos e identificar cómo se expresan en la práctica. La recolección de datos se realizó en dos etapas: primera, revisión conceptual de la literatura publicada entre 1990 y 2020 en revistas y libros de amplia circulación en América Latina, así como entrevistas a dos autoras recurrentes en las publicaciones seleccionadas; segunda, observación participante de una pasantía profesional orientada a estudiantes de pregrado en Terapia Ocupacional de una universidad colombiana y entrevistas a actores sociales involucrados en esa práctica. Se identifica que los términos territorio y comunidad conforman el vocabulario técnico de las y los terapeutas ocupacionales en Colombia; se refieren históricamente a prácticas realizadas en contextos de pobreza, y adquirieron mayor relevancia con el desarrollo de políticas públicas. Se evidencia, además, una actuación territorial-comunitaria relacionada con el modo de vida comunitario y con la apropiación de los recursos materiales, sociales, culturales y relacionales del territorio, desde una perspectiva colectiva de la vida. Se reitera la necesidad de superar el uso de estos conceptos solo como espacios físicos de actuación profesional.

In this observational study, we assessed the association between use of non-nutritive-sweetened soft drink (NNSSD) and risk of gestational diabetes (GDM) in 376 pregnant women consecutively screened for GDM, observing that NNSSD consumption is common among pregnant women and is associated with an increased risk of GDM, independently from traditional risk factors.

Resumo A produção de conhecimentos nacionais da terapia ocupacional se deu de maneira contextualizada em congruência com o desenvolvimento da profissão, em seus diversos campos de atuação. Nas últimas décadas, viu-se a proposição de perspectivas e conceitos ampliados que apontam possíveis interlocuções nessa pluralidade. Nesse sentido, este estudo buscou compreender como a expressão “produção de vida” tem sido utilizada pela literatura nacional da terapia ocupacional, com base em uma revisão bibliográfica de estratégia multidimensional. Consultou-se a base de dados LILACS e periódicos nacionais da área, identificando 29 produções com a expressão “produção de vida” ou semelhante para análise do perfil das publicações, autores, referências e sentidos envolvidos na compreensão da expressão. Os achados se tornaram numericamente mais significativos nos últimos dez anos; estes se relacionavam com temáticas da saúde mental, campo social, artes e cultura, saúde coletiva, fundamentos da terapia ocupacional e campo do trabalho; e os referenciais citaram autores da terapia ocupacional, psiquiatria, filosofia, psicanálise, psicologia, saúde coletiva e antropologia. A análise de sua compreensão indicou quatro categorias: trabalho como emancipação social; ampliação de ações em saúde; experiência criativa e transformação cultural; e manutenção da própria existência. Ressaltando a produção consistente sobre “produção de vida”, concluiu-se que a expressão envolve sentidos na construção de saberes-fazeres mais conectados com o mundo, com as diferentes formas de existir e de protagonizar a vida. Abstract The production of national knowledge of occupational therapy took place in a contextualized way in line with the development of the profession, in its various fields of activity. In the last decades, there were propositions of expanded perspectives and concepts that point to possible interlocutions in this plurality. In this sense, this study sought to understand how the expression “life production” has been used by the national literature of occupational therapy, based on a bibliographic review of multidimensional strategy. The LILACS database and national journals in the area were consulted, identifying 29 productions with the expression “production of life” or similar, to analyze the profile of publications, authors, and references and the meanings involved in understanding the expression. The findings have become numerically more significant over the past ten years; they were related to themes of mental health, social field, arts and culture, collective health, occupational therapy foundations, and work field; and the references cited occupational therapy, psychiatry, philosophy, psychoanalysis, psychology, collective health, and anthropology authors. The analysis of their understanding indicated four categories: work as social emancipation; expanding health actions; creative experience and cultural transformation; and maintenance of existence. Emphasizing the consistent production on the expression 'life production', we concluded that the expression involves meanings in the construction of know-how more connected to the world, the different ways of existing and being the protagonist of life.