15 results on '"Cristina, López López"'
Search Results
2. Papel del endotelio en hipertensión inducida por el embarazo: ¿alteraciones comunes a las de la aterosclerosis?
- Author
-
Patricio López-Jaramillo, Katherine Sotomayor-Rubio, Arístides Sotomayor-Rubio, and Cristina López-López
- Subjects
Endotelio vascular ,embarazo ,hipertensión ,síndrome metabólico ,preeclampsia ,aterosclerosis ,enfermedad cardiovascular ,Medicine ,Medicine (General) ,R5-920 - Abstract
La hipertensión inducida por el embarazo, cuya forma proteinúrica es denominada preeclampsia (PE), es una alteración que ocurre en el segundo trimestre del embarazo, y se caracteriza por la presencia de hipertensión y proteinuria. Durante el embarazo normal ocurren cambios fisiológicos adaptativos que incluyen insulino-resistencia (IR), hiperlipidemia, hipercoagulabilidad, inflamación y un estado circulatorio hiperdinámico. Estos cambios se expresan de una forma exagerada en las mujeres que desarrollan PE, alteraciones que están presentes también en el clúster de factores de riesgo que conforman el denominado síndrome metabólico (SM), el cual es un factor de riesgo para el desarrollo de diabetes mellitus tipo 2 (DM2) y enfermedad cardiovascular (ECV). En la presente revisión proponemos que la disfunción endotelial es la alteración común que explica la presencia de estas dos enfermedades comunes en América Latina.
- Published
- 2014
- Full Text
- View/download PDF
3. Heterotrophic Kinetic Study and Nitrogen Removal of a Membrane Bioreactor System Treating Real Urban Wastewater under a Pharmaceutical Compounds Shock: Effect of the Operative Variables
- Author
-
Antonio Monteoliva-García, Juan Carlos Leyva-Díaz, Cristina López-López, José Manuel Poyatos, María del Mar Muñío, and Jaime Martín-Pascual
- Subjects
heterotrophic kinetics ,membrane bioreactor ,nitrogen ,pharmaceutical shock ,Hydraulic engineering ,TC1-978 ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
Numerous studies have analyzed the viability of the biodegradation and removal of different compounds of emerging concern in biological systems for wastewater treatment. However, the effect on the heterotrophic biomass of organic matter removal is sometimes missed. The aim of the present research was to study the effect of the addition of a mix of three pharmaceuticals (carbamazepine, ciprofloxacin, and ibuprofen) on the behavior of the biomass in two different membrane-based biological systems treating urban wastewater. The present research studied a membrane bioreactor (MBR) pilot plant operating at a similar mixed liquor suspended solids (MLSS) concentration (about 5.5 g/L). This system works as an MBR and is combined with a moving bed biofilm reactor (MBBR-MBR) to treat real urban wastewater at 6 and 10 h of hydraulic retention time (HRT) under three different shocks of pharmaceuticals with increasing concentrations. In all cases, the organic matter removal was, in average terms, higher than about 92% of biochemical oxygen demand on the fifth day (BOD5), 79% of chemical oxygen demand (COD), and 85% of total organic carbon (TOC). Nevertheless, the removal is higher in the MBBR-MBR technology under the same HRT and the MLSS is similar. Moreover, the removal increased during the shock of pharmaceutical compounds, especially in the MBR technology. From a kinetic perspective, MBBR-MBR is more suitable for low HRT (6 h) and MBR is more effective for high HRT (10 h). This could be due to the fact that biofilm systems are less sensitive to hostile environments than the MBR systems. The removal of N-NH4+ decreased considerably when the pharmaceutical compounds mix was introduced into the system until no removal was detected in cycle 1, even when biofilm was present.
- Published
- 2019
- Full Text
- View/download PDF
4. Región: escala de estudio y gestión del desarrollo social
- Author
-
Diana Cristina López-López, Mario Alberto Gaviria-Ríos, and Juan Martín Preciado-Rodríguez
- Abstract
Objetivo: establecer una aproximación teórico-conceptual que fundamente la acotación de una región como escala de estudio al interior de investigaciones enfocadas en temáticas de gestión del desarrollo social. Metodología: análisis de diferentes vertientes teóricas que conciben la región desde perspectivas geográficas, sociológicas y económicas. Resultados: propuesta de acotación de la categoría región como escala espacial de estudio y de gestión del desarrollo social. Limitaciones: la propuesta presentada no considera acotaciones de región desde perspectivas teóricas diferentes a las abordadas en la metodología. Conclusiones: la región constituye una escala apropiada para el estudio y la gestión del desarrollo social en dos sentidos; primero, desde una perspectiva epistemológica, al constituir un nivel de resolución espacial en el que pueden ser estudiados y analizados los procesos económicos, sociales y políticos; segundo, en un sentido ontológico, como una realidad geográfica que demanda ser comprendida en su complejidad para la planificación y gestión de su desarrollo.
- Published
- 2022
5. Noninvasive ventilation in prehospital emergencies
- Author
-
Cristina, López López, Francisco, Ávila Rodríguez, and Fernando, Ayuso Baptista
- Subjects
Emergency Medical Services ,Noninvasive Ventilation ,Humans ,Emergencies ,Respiration, Artificial - Published
- 2022
6. Measurement of macular thickness with optical coherence tomography: impact of using a paediatric reference database and analysis of interocular symmetry
- Author
-
Javier De la Cruz, Cristina López-López, José L. Torres-Peña, Pilar Tejada-Palacios, Martín Rodríguez-Salgado, Alicia Muñoz-Gallego, and Ana Ortueta-Olartecoechea
- Subjects
Adult ,Male ,Percentile ,Multivariate statistics ,medicine.medical_specialty ,Biometry ,genetic structures ,Spherical equivalent ,Refraction, Ocular ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,European origin ,Optical coherence tomography ,Reference Values ,Ophthalmology ,medicine ,Humans ,Macula Lutea ,Child ,medicine.diagnostic_test ,business.industry ,eye diseases ,Sensory Systems ,Cross-Sectional Studies ,Eye examination ,Reference values ,030221 ophthalmology & optometry ,Reference database ,sense organs ,business ,Tomography, Optical Coherence ,030217 neurology & neurosurgery - Abstract
Optical coherence tomography (OCT) software is used to classify abnormality of macular thickness by colour category based on reference data from adult series. We assessed the impact of using paediatric reference thickness values for macular thickness instead of adult reference values. Cross-sectional study. Primary and tertiary healthcare setting. Out of 140 healthy participants aged 5 to 18 years, 126 were eligible, 83% from European origin. Following a dilated eye examination and cycloplegic refraction, participants underwent macular scanning with OCT (Topcon 3D OCT-2000). Macular thickness paediatric reference values were recorded by spherical equivalent (SE) and sex, and the specific agreement between paediatric and adult reference values below or equal to percentile 5 and above percentile 95 was estimated. The absolute interocular differences for all macular parameters were determined. Multivariate regression analysis confirmed statistically independent positive associations between SE and average thickness, total volume, and temporal and inferior outer quadrants (all p values ≤ 0.003). The analysis also revealed higher values in males for average thickness, central thickness, and all inner macula quadrants (all p values ≤ 0.039). The use of the adult database only detected 49% of the extreme values (≤ p5 and > p95) in our paediatric sample. The 95th percentile limits for absolute interocular differences for all macular parameters ranged from 12 to 17 μm. OCT-based macular reference values for paediatric SE and sex improve detection of children with abnormal macular thicknesses. Interocular differences exceeding standard references for macular parameters should be considered for further examinations.
- Published
- 2020
7. Potential negative pharmacodynamic interaction of spironolactone and abiraterone in two prostate cancer patients
- Author
-
Juan Vicente-Valor, Vicente Escudero-Vilaplana, Roberto Collado-Borrell, Cristina López-López, Cristina Villanueva-Bueno, José Luis Revuelta-Herrero, Paula Ruiz-Briones, Beatriz Somoza-Fernández, Ana Herranz, and María Sanjurjo
- Subjects
Oncology ,Pharmacology (medical) - Abstract
Introduction Spironolactone when combined with abiraterone in metastatic castration-resistant prostate cancer (mCRPC) may theoretically exert androgenic properties, thereby compromising the therapeutic effectiveness of abiraterone. Case report Two patients with a medical history of cardiovascular disease and mCRPC combined spironolactone within the course of abiraterone regimen. The abiraterone-spironolactone interaction was identified using the Lexicomp® interaction tool (classified as risk C). Management & outcome Spironolactone treatment was maintained as it was considered beneficial due to the cardiac condition. The prostate-specific antigen (PSA) levels started to rise when these two drugs were used together. Eventually, tumour progression was observed. Discussion There is increasing evidence that spironolactone behaves as a selective androgen receptor modulator. Strategies to overcome abiraterone-spironolactone interaction could involve the use of eplerenone, although this drug is also controversial. The best strategy should imply a multidisciplinary evaluation by cardiologists and oncologists.
- Published
- 2022
8. Macular thickness variation and interocular symmetry by gestational age in preterm school-age children
- Author
-
José L. Torres-Peña, Ana I. Ortueta-Olartecoechea, Alicia Muñoz-Gallego, Cristina López-López, Maria J. Torres-Valdivieso, Javier de-la-Cruz, and Pilar Tejada-Palacios
- Subjects
Fovea Centralis ,Ophthalmology ,Cross-Sectional Studies ,Pediatrics, Perinatology and Child Health ,Infant, Newborn ,Visual Acuity ,Humans ,Gestational Age ,Macula Lutea ,Tomography, Optical Coherence - Abstract
To determine changes in macular thickness profile according to gestational age (GA) and to assess interocular symmetry in the macula of children born very preterm.In this cross-sectional study of preterm (n = 106) and term-born (n = 49) children 5-8 years of age at time of examination, optical coherence tomography was used to measure macula thickness as described in the ETDRS study. Statistical analyses included stratified and multivariable analyses.Foveal minimum thickness increased with decreasing GA (P for trend,0.001; 254.7 ± 32.8 μm for children born at 24-25 weeks and 193.2 ± 32.8 μm in term-born children). Inner and outer area thickness differed for term and preterm children, but did not vary with the degree of prematurity (inner area, 267.0 ± 11.0 μm for 24-25 weeks' GA and 305.4 ± 11.8 μm for term children [P0.01]; outer ring, 305.5 ± 10.4 μm in extreme preterm and 271.0 ± 10.4 μm in term children [P0.01]). Interocular asymmetry in preterm children was not significant for most areas; the largest interocular difference was found in the central zone (16.3 ±16.6 μm).In our study cohort, children born very preterm examined at school age compared to term born children had greater central thickness with decreased foveal pit, decreased inner ring, and increased thickness of the outer ring. They did not show greater interocular asymmetry.
- Published
- 2022
9. Equidad gerencial, como una demanda intangible de mercado: hacia organizaciones sustentables
- Author
-
Martín Robles Parra, Karla Terán Samaniego, Diana Cristina López López, and Juan Martín Preciado Rodríguez
- Subjects
Process (engineering) ,media_common.quotation_subject ,05 social sciences ,Equity (finance) ,04 agricultural and veterinary sciences ,General Medicine ,040501 horticulture ,Supply and demand ,Product (business) ,0502 economics and business ,Sustainability ,Conceptual structure ,Quality (business) ,Business ,Sustainability organizations ,0405 other agricultural sciences ,050203 business & management ,Industrial organization ,media_common - Abstract
El presente artículo da cuenta de los fundamentos referenciales de cómo el mercado condiciona a las organizaciones para competir con atributos intangibles del producto, mismos que se relacionan con los componentes básicos de la sustentabilidad (social, ambiental y económico). De igual manera fundamenta cómo la equidad gerencial, como una demanda intangible de mercado, propicia cambios organizacionales hacia la sustentabilidad. Estas bases conceptuales no aparecen de manera tácita en las revisiones de literatura, y constituyen una importante estructura conceptual para abordar el análisis de las organizaciones. En la literatura, las investigaciones que tratan el tema de la equidad gerencial, como una demanda intangible de mercado que propicia cambios organizacionales para transitar hacia la sustentabilidad, es limitada, y es crucial mencionar que el proceso de su integración en la gerencia se traduce en garantía de calidad y excelencia empresarial que da respuesta a una demanda intangible de mercado, la cual coadyuva a la conformación de organizaciones sustentables.
- Published
- 2019
10. Una mirada a las estrategias y técnicas didácticas en la educación en ingeniería. Caso Ingeniería Industrial en Colombia
- Author
-
Diana Cristina López López and L.A. Mejía
- Subjects
020209 energy ,0202 electrical engineering, electronic engineering, information engineering ,02 engineering and technology ,010501 environmental sciences ,01 natural sciences ,0105 earth and related environmental sciences - Abstract
En la medida en que ha evolucionado el proceso de enseñanza-aprendizaje en diferentes disciplinas, se han generado diferentes propuestas de uso de estrategias didácticas para fortalecer la formación en ingeniería. Para el caso de Ingeniería Industrial, surge la inquietud sobre la forma en que estas estrategias, acompañadas de diferentes técnicas didácticas, se están articulando actualmente en el proceso de formación. El presente artículo expone diferentes didácticas que se están empleando en la formación en Ingeniería Industrial en Colombia, analizando la forma en que algunas de ellas han generado impacto en el desempeño del ingeniero en formación, e ilustra casos concretos de implementación en dos áreas de esta disciplina: Control de Calidad e Investigación de Operaciones. Se presentan refl exiones sobre cómo se articulan diferentes técnicas dentro del desarrollo curricular, según la experiencia de las autoras, además de identifi car aquellas técnicas que generan un impacto signifi cativo en el estudiante.
- Published
- 2017
11. Región: escala de estudio y gestión del desarrollo social.
- Author
-
Cristina López-López, Diana, Alberto Gaviria-Ríos, Mario, and Martín Preciado-Rodríguez, Juan
- Subjects
- *
SOCIAL development , *SOCIAL processes , *REGIONAL development , *SOCIAL policy , *SPATIAL resolution , *POLYSEMY , *THEORY of knowledge - Abstract
Objective: To establish a theoretical-conceptual approach that bases the delimitation of a region as a scale of study within research focused on social development management issues. Methodology: Analysis of different theoretical aspects that conceive the region from geographical, sociological and economic perspectives. Results: Proposal for the delimitation of the region category as a spatial scale for the study and management of social development. Limitations: The proposal presented does not consider region delimitations from other theoretical perspectives than those addressed in the methodology. Conclusions: The region constitutes an appropriate scale for the study and management of social development in two senses. First, from an epistemological perspective, by constituting a level of spatial resolution in which economic, social and political processes can be studied and analysed; second, in an ontological sense, as a geographical reality that demands to be understood in its complexity for the planning and management of its development. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
12. Caracterización térmica de nanocintas ferromagnéticas en experimentos de transferencia de espín
- Author
-
Cristina López López, Prieto, J. L., Muñoz Sánchez, Manuel, and Prieto Martín, José Luis
- Subjects
Telecomunicaciones ,3. Good health - Abstract
Tesis llevada a cabo para conseguir el grado de Doctor por la Universidad Politécnica de Madrid.--2018-03-23.--Sobresaliente Cum Laude, [ES] La posibilidad de manipular la imanación con corriente polarizada en espín en nanoestructuras ferromagnéticas, unida a la propuesta para la memoria Racetrack ha motivado intensamente el estudio dinámico de paredes de dominio en nanocintas ferromagnéticas. El funcionamiento de la memoria Racetrack se basa en el movimiento localizado de una secuencia de bits magnéticos (dominios magnéticos separados por paredes) en una pista de memoria, que es una nanocinta ferromagnética. El movimiento de esta secuencia de bits magnéticos debe obedecer únicamente a un flujo de corriente eléctrica, vía transferencia de espín. En un experimento de desenganche inducido por corriente, un dispositivo típico sería una nanocinta ferromagnética de centenas de nanómetros de ancho y unos pocos de espesor, con un estrechamiento en el medio, donde se ancla la pared de dominio. Al aplicar corriente eléctrica, la pared se mueve, se desengancha del defecto o transforma su estructura debido a la transferencia de espín. La corriente eléctrica puede ser DC; pero a menudo se aplica en pulsos del rango de nanosegundos, ya que el valor crítico de densidad de corriente que se requiere para que se produzca transferencia de espín es típicamente del orden de 108/cm2. El calentamiento Joule generado por una densidad de corriente tan elevada es un problema a tener en cuenta, incluso si esta se aplica en pulsos ultracortos. El aumento de temperatura inducido por el calentamiento Joule podría llevar al dispositivo a una temperatura cercana o superior a la temperatura de Curie (Tc), consecuencia fatal en el caso de una memoria Racetrack, pues se perdería la estructura de bits magnéticos de la nanocinta, dañando la información almacenada. Además, en la mayor parte de experimentos de desenganche de paredes de dominio con corriente esta genera gradientes térmicos dentro de la nanoestructura, junto a los contactos metálicos y en torno a la constricción; estos gradientes ya han sido asociados a efectos sobre el movimiento de las paredes. La correcta interpretación de los resultados es una tarea compleja, pues los resultados pueden parecer, a primera vista, contradictorios entre sí. Este trabajo aborda una caracterización rigurosa del comportamiento térmico de las nanocintas ferromagnéticas durante un experimento de transferencia de espín. En primer lugar, se ha desarrollado un modelo numérico del comportamiento térmico de los dispositivos, que ha sido calibrado con la respuesta experimental de nanocintas reales. Este modelo explica la controversia entre trabajos previos que estiman la temperatura media en nanocintas magnéticas cuando una corriente eléctrica fluye a través del dispositivo, usando corriente DC, pulsos largos de corriente o pulsos muy cortos de nanosegundos. Señala además directrices nuevas en cuanto al procesado de muestras experimentales (geometría, sustrato) y en cuanto al sistema experimental (corriente DC, corriente pulsada, duración de pulso) a utilizar en experimentos de transferencia de espín. En la actualidad existen trabajos recientes de simulación micromagnética combinada con transporte de calor que han reproducido experimentos previos en los que se descubre que la contribución de la transferencia de espín en comparación con la contribución térmica era apenas relevante. En consecuencia, la adecuada comprensión e identificación experimental de la transferencia de espín sigue constituyendo un desafío experimental a tener en cuenta. Los resultados obtenidos en las simulaciones numéricas permitirán la implementación de experimentos de desenganche de pared donde los eventos de origen térmico y los de transferencia de espín se evidencien y se distingan. Los resultados abren un camino muy interesante para la caracterización de este fenómeno, [EN] The possibility of controlling the local magnetization with spin-polarized current in ferromagnetic nanostructures along with the proposal of the Racetrack memory has intensively encouraged the dynamic study of domain-walls in ferromagnetic nanostripes. Racetrack memory relies on the localized movement of a sequence of magnetic bits (defined by magnetic domains and domain-walls) in a memory track, which consists on a ferromagnetic nanostripe. The synchronized movement of this sequence must only follow the injection of electric current via spin transfer. In a current-induced depinning experiment, a typical dispositive consists on a ferromagnetic nanostripe of hundreds of nanometers wide and a few nanometers thick, with a constriction in the middle, able to trap a propagating domain-wall. As the electrical current is applied, a domain-wall may move, depin or transform its inner structure because of the spin transfer. Applied current can be both DC or RF; it is often injected in pulsed regime since the critical current density values which show spin transfer are typically high, around 108 A/cm2. Joule heating generated from such a high current density is a serious drawback for the consecution of this experiments, even if it is delivered in ultrashort pulses. The rise of temperature induced by Joule heating could lead the dispositive to a temperature value close enough or above to Curies point, which would lead to data corruption in a Racetrack dispositive, since the track would lose its magnetic bits structure. Besides, in most depinning experiments, electric current generates thermal gradients within the nanostructure, close to the metallic contact pads and in the constriction area; this gradients have already been associated to dynamic effects on domain-walls. A strict interpretation of results becomes complex, because results can easily seem to be contradictory. This work offers a rigorous thermal characterization of the ferromagnetic nanostripes in a spin transfer experiment. First of all, a numerical model has been developed which fits the experimental response of real nanostripes. This model gives an explanation to the controversy between previous works which estimate the average temperature of the nanostripe when an electric current flows through the dispositive, using DC current or long or short current pulses. It points out new directions regarding the fabrication of experimental samples (geometry, use of new substrates) and the experimental set-up (DC or RF regime, pulse length) when approaching spin transfer experiments. Recent micromagnetic simulations coupled to heat transport models have reproduced previous depinning experiments revealing a marginal influence of the spin transfer in comparison with thermal effects. Consequently, a proper comprehension and experimental identification of the spin transfer keeps being an unsolved experimental problem. Armed with the data provided by the numerical model, domain-wall depinning experiments will be implemented, identifying both thermal and magnetic effects. The results shown in this work offer new and exciting perspectives for the spin transfer characterization.
- Published
- 2018
13. Ingeniería: Clave en el desarrollo sostenible
- Author
-
Diana Cristina López López
- Abstract
La economía mundial en la actualidad abastece un estimado a 2015 de 7.200 millones de personas, cifra que dista considerablemente de los 800 millones al inicio de la revolución industrial; hoy lo logra a través de la interconexión comercial, financiera, tecnológica, productiva e incluso, interconectando aspectos que pudieran resultar disímiles como las migraciones y las redes sociales. A futuro, dicha economía deberá ser capaz de hacerlo en un escenario de crecimiento poblacional global esperado de 75 millones de habitantes por año [1].
- Published
- 2019
14. [Treatment of the patient with castration-resistant biochemical progression of prostate cancer]
- Author
-
José Angel Arranz, Arija, Rafael González, Beca, Cristina López, López, Pilar Sabin, Domínguez, Alicia Soria, Lovelle, and Yolanda Jerez, Gilarranz
- Subjects
Male ,Drug Resistance, Neoplasm ,Disease Progression ,Humans ,Prostatic Neoplasms ,Androgen Antagonists ,Testosterone ,Treatment Failure ,Prostate-Specific Antigen - Abstract
Castration resistant prostatic carcinoma (CRPC) is defined as tumor progression despite an effective castration (serum testosterone levels50 ng/dL). Biochemical progression requires at least two successive increases from the previous lowest value of serum prostate-specific antigen (PSA) spaced at least a week, and with a minimum value of 2 ng/mL. In patients receiving complete androgen blockade, antiandrogen should be discontinued prior to diagnosis of CRPC. CPRC is a heterogeneous entity. Baseline PSA and PSA velocity seem to be the most important prognostic factors in patients with biochemical relapse as the only manifestation of CRPC. Some of these patients can be followed without treatment until disease progression. Because of a large proportion of tumors progressing under androgen deprivation therapy remain hormone-dependent, the use of other hormonal therapies has been the preferred treatment for the majority of these patients. Besides inhibitors of adrenal steroidogenesis, other novel hormonal approaches are currently under investigation to avoid the effect of the activated androgenic receptor on the tumor cell. In recent years there has been an important development of immunotherapy, which has demonstrated to increase survival in CRPC oligosymptomatic patients. First and second line chemotherapy in CRPC are associated with an increase in overall survival, but they are usually recommended for patients with metastases. Until the results of ongoing trials are available, the type and timing of the treatment for patients with CRPC and biochemical recurrence should be individualized.
- Published
- 2012
15. First one thousand families: Our multidisciplinary experience in the heredo-familial cancer unit from a Spanish University Hospital
- Author
-
Mercedes Sanz, S. Lizarraga, Jesus Solera, Cristina López López, Sara López-Tarruella, Oscar Bueno, Patricia Rincon, Miguel Martin, Maria Die Trill, Aitana Calvo, Cecilia González Asanza, Andres J. Muñoz Martín, Maria Isabel Peligros, Soledad Luque Molina, Cristina Mata, Jose Antonio Pajares, Yolanda Jerez Gilarranz, Carmen Flores Sanchez, Pedro Menchén, and Ivan Marquez Rodas
- Subjects
Cancer Research ,Pediatrics ,medicine.medical_specialty ,Oncology ,Hereditary Cancer Syndromes ,Multidisciplinary approach ,business.industry ,Medicine ,Familial Cancer ,University hospital ,business ,Unit (housing) - Abstract
1556 Background: Patients with hereditary cancer syndromes (HCS) need a multidisciplinary approach: Different organs and systems may be involved and different risk reducing strategies (medical and ...
- Published
- 2015
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.