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1. Effects of Solanum tuberosum L. ointment on second-degree burns in mice

Author

Carmen R. Silva-Correa, Galy P. Rosas-Cruz, Abhel A. Calderón-Peña, Víctor E. Villarreal-La Torre, Cinthya L. Aspajo-Villalaz, Julio A. Castañeda-Carranza, Deivy Y. Dionicio-Rosado, Ricardo M. Gómez-Arce, Cristhian N. Rodríguez-Silva, Jorge Del Rosario-Chávarri, and José L. Cruzado-Razco

Subjects
burn healing, herbal medicine, histopathology, ointment, potato, skin, solanum tuberosum l, Animal culture, SF1-1100, Veterinary medicine, SF600-1100
Abstract

Background and Aim: Potato (Solanum tuberosum L.) is mainly characterized by its antioxidant and healing properties. Therefore, this study aimed to evaluate the effects of an ointment based on S. tuberosum L. “papa tumbay” on burns induced in Balb/c mice (Mus musculus). Materials and Methods: The experimental animals were divided into four groups (n = 5/group) 48 h before second-degree burns were inducted. After epilating the loin areas of the mice and anesthetizing them with ketamine/xylazine (80 mg/kg/10 mg/kg) through intraperitoneal (i.p.) route, a round metal rod (0.7 cm in diameter) was placed on the depilated skin at a temperature of 100°C for 5 s. Group I was not given any treatment, Group II was treated with silver sulfadiazine (1%), and the other two groups (III and IV) were treated with the ointment formulated based on S. tuberosum L. “papa tumbay” at 1% and 2%, respectively. After performing the treatment for 21 days, the mice were euthanized using i.p. sodium pentobarbital (185 mg/kg) to obtain skin samples. The samples were preserved in 10% neutral-buffered formalin and subjected to histopathological analysis. Results: We found statistically significant differences in the histopathological sections between the groups (p < 0.05). The abundant collagen and fibroblasts observed in the direction of the dermis in Groups III and IV indicate that the phytoconstituents present in the potato might promote the healing of the second-degree burns until day 21 of treatment. Conclusion: Our findings showed that the ointments based on the ethanolic extracts of S. tuberosum L. “papa tumbay,” especially the 2% ointment, might accelerate the healing of second-degree burns induced in Balb/c mice.

Published
2023
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2. The Medicinal Chemistry of Chalcones as Anti-Mycobacterium tuberculosis Agents

Author

Jean Leandro Dos Santos, Cristhian N. Rodríguez-Silva, and Igor Muccilo Prokopczyk

Subjects
Pharmacology, Drug Discovery, General Medicine
Abstract

Abstract: Tuberculosis (TB), a highly fatal infectious disease, is caused by Mycobacterium tuberculosis (Mtb) that has inflicted mankind for several centuries. In 2019, the staggering number of new cases reached 10 million resulting in 1.2 million deaths. The emergence of multidrug-resistance- Mycobacterium tuberculosis (MDR-TB) and extensively drug-resistant-Mycobacterium tuberculosis (XDR-TB) is a global concern that requires the search for novel, effective, and safer short-term therapies. Nowadays, among the few alternatives available to treat resistant-Mtb strains, the majority have limitations, which include drug-drug interactions, long-term treatment, and chronic induced toxicities. Therefore, it is mandatory to develop new anti-Mtb agents to achieve health policy goals to mitigate the disease by 2035. Among the several bioactive anti-Mtb compounds, chalcones have been described as the privileged scaffold useful for drug design. Overall, this review explores and analyzes 37 chalcones that exhibited anti-Mtb activity described in the literature up to April 2021 with minimum inhibitory concentration (MIC90) values inferior to 20 μM and selective index superior to 10. In addition, the correlation of some properties for most active compounds was evaluated, and the main targets for these compounds were discussed.

Published
2022

4. Tuberculosis: Integrated Studies for a Complex Disease 2050

Author

Nima Rezaei, Nastaran-Sadat Hosseini, Amene Saghazadeh, Abolfazl Fateh, Adriano Duse, Aijaz Ahmad, Alexander E. Braley, Alican Tahta, Alisha Kamboj, Amer Hayat Khan, Ana Cláudia Coelho, Andrea Fuso, Andrés Varón, Anete Trajman, Anil Kumar Saxena, Ankit Ganeshpurkar, Anthony M. Casapao, Anton Tkachenko, Anushka V. Devnikar, Arfa Moshiri, Arrate Muñoz-Barrutia, Arunava Dasgupta, Arvind Natarajan, Ashish Gupta, Ashlan J. Kunz Coyne, Ashly E. Jordan, Ashok Kumar, Atadzhan Ergeshov, Babak Pourakbari, Basant Joshi, Bibiana Chavarro-Portillo, Carlos Y. Soto, Carly Kanipe, Christiane Mello Schmidt, Christophe Cox, Clara Gómez-Cruz, Claudete Aparecida Araújo Cardoso, Clemax Couto Sant´Anna, Courtney Johnson, Cristhian N. Rodríguez-Silva, Cristian Rosales, Cuauhtémoc Licona-Cassani, Cynthia D. Fast, Damián Pérez-Martínez, Damiano Pizzol, David C. Perlman, Dennis Philips, Diana Viveros, Dina A. Fisher, Dmytro Butov, Eric F. Egelund, Everest de Igartua, Garima Bhatt, Georgies Mgode, Gianluca Quaglio, Giovanni Putoto, G. K. Mini, Govind Thomas-Richardson, Greg Wylie, Guilherme Felipe dos Santos Fernandes, Gustavo Bermúdez, Hélder Quintas, Himanshu Verma, Hyungjin Eoh, Ikhwanuliman Putera, Ilya Sivokozov, Isabel Pires, Jae Jin Lee, Jason E. Lombard, Jean Leandro dos Santos, Jean-Pierre Zellweger, Jenu Thomas-Richardson, Jinbert Lordson, João Lucas Prates, Jorge Cervantes, José M. Porcel, Juan José Vaquero, Justina Prada, Kamal Kamboj, Khalid F. Tabbara, Kirubel Manyazewal Mussie, Krupesh Patel, Laura Porcel, Lena Fiebig, Malu Mohan, Mange Ram Yadav, Marcela López-R, Margarida Correia-Neves, Maria da Conceição Fontes, Maria de Fátima Pombo Bazhuni Sant´Anna, Marina Cañadas-Ortega, Meenakshi Singh, Michael Lause, Milena Maya-Hoyos, Mir Davood Omrani, Mitchell V. Palmer, Mohammad Naiyaz Ahmad, Mohammed Assen Seid, Monica Chauhan, Mridula Saxena, Musa Marimani, Nanduri Srinivas, Negussie Beyene, Nelson E. Arenas, Nicole Cardoso, Olena Oliveira, Om Silakari, Osvaldo Inlamea, Özgür Tanrıverdi, Paola M. Boggiatto, Paola Santos, Paulina Mejía-Ponce, Pedro Soares, Philip Sell, Prashant R. Murumkar, Praveen Devanandan, Qi Zheng, Rachel K. Lim, Rafaela Baroni Aurílio, Rahul B. Ghuge, Rahul R. Barot, null Rahul, Ranadheer Chowdary Puvvada, Raquel Duarte, Ravi Singh, Richa Sinha, Rina La Distia Nora, Robert Burny, Roberto Zenteno-Cuevas, Sagar Mali, Samir S. Shoughy, Samira Tarashi, Sapna Mishra, Satyaveni Malasala, Setareh Mamishi, Seyed Davar Siadat, Shalki Choudhary, Shima Mahmoudi, Sidharth Chopra, Sisir Nandi, Sobia Faisal, Sonu Goel, Stanislav Huszár, Stephen K. Field, Sushil Kumar Singh, Teresa Rito, Tetiana Butova, Thomas Manning, Tjip S. van der Werf, Valeriy Myasoedov, Vanessa Vásquez, Vijey Aanandhi Muthukumar, Vinayak Singh, Walter A. Hall, Wandya Hikmahwati, Yaşar Barış Turgut, Yatri Thaker, Yoshinori Kawabata, and Yvette A. de Reus

Published
2023

5. The Medicinal Chemistry of Chalcones as Anti

Author

Cristhian N, Rodríguez-Silva, Igor Muccilo, Prokopczyk, and Jean Leandro, Dos Santos

Subjects
Chalcone, Chalcones, Chemistry, Pharmaceutical, Tuberculosis, Multidrug-Resistant, Antitubercular Agents, Humans, Tuberculosis, Microbial Sensitivity Tests, Mycobacterium tuberculosis
Abstract

Tuberculosis (TB), a highly fatal infectious disease, is caused by Mycobacterium tuberculosis (Mtb) that has inflicted mankind for several centuries. In 2019, the staggering number of new cases reached 10 million resulting in 1.2 million deaths. The emergence of multidrug-resistance- Mycobacterium tuberculosis (MDR-TB) and extensively drug-resistant-Mycobacterium tuberculosis (XDR-TB) is a global concern that requires the search for novel, effective, and safer short-term therapies. Nowadays, among the few alternatives available to treat resistant-Mtb strains, the majority have limitations, which include drug-drug interactions, long-term treatment, and chronic induced toxicities. Therefore, it is mandatory to develop new anti-Mtb agents to achieve health policy goals to mitigate the disease by 2035. Among the several bioactive anti-Mtb compounds, chalcones have been described as the privileged scaffold useful for drug design. Overall, this review explores and analyzes 37 chalcones that exhibited anti-Mtb activity described in the literature up to April 2021 with minimum inhibitory concentration (MIC

Published
2021

6. La automedicación como riesgo de fracaso terapéutico contra el COVID-19

Author

Cristhian N. Rodríguez-Silva and Cynthia R. Tello-Reyna

Subjects
Marketing, Pharmacology, Organizational Behavior and Human Resource Management, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Strategy and Management, Pharmaceutical Science, Drug Discovery, medicine, Therapeutic failure, Intensive care medicine, business, Self-medication
Abstract

DOI: http://dx.doi.org/10.17268/rmt.2020.v15i03.06

Published
2020

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