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3. Central obesity, body mass index, metabolic syndrome and mortality in Mediterranean breast cancer patients

Author

Crispo, Anna, Augustin, Livia S. A., Luongo, Assunta, Calderaio, Claudia, Breda, Joao, Coluccia, Sergio, Calabrese, Alessandra, Marrazzo, Vittorio, Giannatiempo, Rosa, Trasacco, Paola, Palumbo, Elvira, Vitale, Sara, Porciello, Giuseppe, Di Gennaro, Piergiacomo, Caputo, Roberta, Buono, Giuseppe, Vernieri, Claudio, Schettini, Francesco, Grimaldi, Maria, Nocerino, Flavia, Celentano, Egidio, Amore, Alfonso, Giuliano, Mario, De Placido, Pietro, De Angelis, Carmine, Bianco, Roberto, De Laurentiis, Michelino, La Vecchia, Carlo, and Arpino, Grazia

Published
2023
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4. Oligo-metastatic neoPlasms from the gastro-intestinal tract: iDentIfiCaTIon of cliNical and molecular drivers: the PREDICTION study

Author

Ottaiano, Alessandro, De Luca, Antonella, Santorsola, Mariachiara, Scognamiglio, Giosuè, Di Mauro, Annabella, Chiodini, Paolo, Lambiase, Matilde, Sacco, Alessandra, Petrillo, Antonella, Granata, Vincenza, Fusco, Roberta, Mercadante, Edoardo, Martucci, Nicola, De Luca, Giuseppe, Rocca, Antonello La, Celentano, Egidio, Crispo, Anna, Di Gennaro, Piergiacomo, Tatangelo, Fabiana, Ferrara, Gerardo, Izzo, Francesco, Belli, Andrea, Patrone, Renato, Delrio, Paolo, Rega, Daniela, De Franciscis, Silvia, Muto, Paolo, Ravo, Vincenzo, Di Franco, Rossella, Borzillo, Valentina, Santagata, Sara, Rea, Giuseppina, Castaldo, Daniela, Pace, Ugo, De Feo, Gianfranco, Scala, Stefania, Nasti, Guglielmo, and Normanno, Nicola

Published
2023
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10. Life style and interaction with microbiota in prostate cancer patients undergoing radiotherapy: study protocol for a randomized controlled trial

Author

Gnagnarella, Patrizia, Marvaso, Giulia, Jereczek-Fossa, Barbara Alicja, de Cobelli, Ottavio, Simoncini, Maria Claudia, Nevola Teixeira, Luiz Felipe, Sabbatini, Annarita, Pravettoni, Gabriella, Johansson, Harriet, Nezi, Luigi, Muto, Paolo, Borzillo, Valentina, Celentano, Egidio, Crispo, Anna, Pinto, Monica, Cavalcanti, Ernesta, and Gandini, Sara

Published
2022
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11. Assessing Gender Differences for Non-Predictable Breakthrough Cancer Pain Phenomenon: A Secondary Analysis from IOPS-MS Study.

Author

Bimonte, Sabrina, Gennaro, Piergiacomo Di, Crispo, Anna, Coluccia, Sergio, Luongo, Assunta, Amore, Alfonso, Celentano, Egidio, Del Prato, Francesco, Schiavo, Daniela, Nocerino, Davide, Cascella, Marco, and Cuomo, Arturo

Subjects
GENDER differences (Psychology), KARNOFSKY Performance Status, CLUSTER analysis (Statistics), SECONDARY analysis, MULTIVARIATE analysis
Abstract

Purpose: Breakthrough cancer pain (BTcP) is a temporary exacerbation of pain that "breaks through" a phase of adequate pain control by an opioid-based therapy. The non-predictable BTcP (NP-BTcP) subtype occurs in the absence of any specific activity. Evidence showed that gender differences exist in pain response sensitivity and clinical pain risk. This analysis aimed to signify the gender differences for the NP-BTcP phenomenon. Patients and Methods: This is a secondary analysis of the Italian Oncologic Pain multiSetting-Multicentric Survey (IOPS-MS), the largest study on BTcP. The subset of NP-BTcP cases for non-gender-specific cancer was considered. Univariable and multivariate analyses were conducted to identify gender differences for the NP-BTcP profile about its intensity, number of episodes per day, and type. A metastatic status-stratified analysis was performed to compare gender with the main clinical variables among the population with NP-BTcP. Results: Males exhibited a higher occurrence of BTcP in the thorax region compared to females (15% vs 11%, respectively, p = 0.03). Males also had a higher onset of BTcP, a higher BTcP therapy dosage (33% vs 28%, p = 0.04, mean: 201 vs 186, p = 0.02) and a lower Karnofsky score (mean: 46.9 vs 49.2, p = 0.03) compared to females. Similar gender differences were found for metastatic patients in the BTcP site (14% vs 8.5%, respectively; p = 0.01), peak onset (33% vs 27%, p = 0.02), BTcP therapy dosage (199 vs 185, p=0.04), and Karnofsky score (mean 47.5 vs 50.4, p = 0.009). Phenotype 2 was more characterized by non-metastatic males (41% vs 23%, p = 0.020) while non-metastatic females presence was predominant among others. Conclusion: In this study, gender differences according to site, onset and dosage of BTcP were found. The phenotype characterization of BTcP needs to be further investigated for a possible useful function in the management of cancer-related pain in non-metastatic patients. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Diabetes Risk Reduction Diet and Colorectal Cancer Risk

Author

Natale, Arianna, primary, Turati, Federica, additional, Taborelli, Martina, additional, Giacosa, Attilio, additional, Augustin, Livia S.A., additional, Crispo, Anna, additional, Negri, Eva, additional, Rossi, Marta, additional, and La Vecchia, Carlo, additional

Published
2024
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14. Assessing Gender Differences for Non-Predictable Breakthrough Cancer Pain Phenomenon: A Secondary Analysis from IOPS-MS Study

Author

Bimonte,Sabrina, Di Gennaro,Piergiacomo, Crispo,Anna, Coluccia,Sergio, Luongo,Assunta, Amore,Alfonso, Celentano,Egidio, Del Prato,Francesco, Schiavo,Daniela, Nocerino,Davide, Cascella,Marco, Cuomo,Arturo, Bimonte,Sabrina, Di Gennaro,Piergiacomo, Crispo,Anna, Coluccia,Sergio, Luongo,Assunta, Amore,Alfonso, Celentano,Egidio, Del Prato,Francesco, Schiavo,Daniela, Nocerino,Davide, Cascella,Marco, and Cuomo,Arturo

Abstract

Sabrina Bimonte,1,* Piergiacomo Di Gennaro,2,* Anna Crispo,2 Sergio Coluccia,2 Assunta Luongo,2 Alfonso Amore,3,4 Egidio Celentano,2 Francesco Del Prato,1 Daniela Schiavo,1 Davide Nocerino,1 Marco Cascella,5 Arturo Cuomo1 1Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, Italy; 2Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, Italy; 3Melanoma and Sarcoma Surgery Unit, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, Italy; 4PhD School of Applied Medical-Surgical Sciences, University of Rome Tor Vergata, Rome, Italy; 5Department of Medicine, University of Salerno, Salerno, Italy*These authors contributed equally to this workCorrespondence: Anna Crispo, Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Via Mariano Semmola 53, Naples, Italy, Tel +39 081 17770298, Email a.crispo@istitutotumori.na.itPurpose: Breakthrough cancer pain (BTcP) is a temporary exacerbation of pain that “breaks through” a phase of adequate pain control by an opioid-based therapy. The non-predictable BTcP (NP-BTcP) subtype occurs in the absence of any specific activity. Evidence showed that gender differences exist in pain response sensitivity and clinical pain risk. This analysis aimed to signify the gender differences for the NP-BTcP phenomenon.Patients and Methods: This is a secondary analysis of the Italian Oncologic Pain multiSetting-Multicentric Survey (IOPS-MS), the largest study on BTcP. The subset of NP-BTcP cases for non-gender-specific cancer was considered. Univariable and multivariate analyses were conducted to identify gender differences for the NP-BTcP profile about its intensity, number of episodes per day, and type. A metastatic status-stratified analysis was performed to compare gender with the main clinical variables among the population with NP-BTcP.Results: Males exhibited a higher

Published
2024

15. Adherence to a Cholesterol-Lowering Diet and the Risk of Pancreatic Cancer: A Case–Control Study.

Author

Di Maso, Matteo, Augustin, Livia S. A., Jenkins, David J. A., Crispo, Anna, Toffolutti, Federica, Negri, Eva, La Vecchia, Carlo, Ferraroni, Monica, and Polesel, Jerry

Abstract

Background: Pancreatic cancer risk has been associated with increased serum cholesterol level, which is in turn partially influenced by diet. This study aimed at evaluating the association between pancreatic cancer risk and the adherence to a plant-based cholesterol-lowering diet. Methods: Data were derived from an Italian case–control study including 258 pancreatic cancer patients and 551 controls. The cholesterol-lowering diet score was based on seven components: high intakes of (i) non-cellulosic polysaccharides (a proxy of viscous fibers), (ii) monounsaturated fatty acids, (iii) legumes, and (iv) seeds/corn oils (a proxy of phytosterols); and low intakes of (v) saturated fatty acids, (vi) dietary cholesterol, and (vii) food with a high glycemic index. The score was calculated adding one point for each fulfilled component, thus ranging from zero (no adherence) to seven (complete adherence). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated through the logistic regression model. Results: Scores 5–7 were associated with reduced cancer risk (OR = 0.30; 95% CI: 0.18–0.52) compared to scores 0–2. Conclusions: Adherence to a plant-based cholesterol-lowering diet was associated with a reduced risk of pancreatic cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Influenza Vaccination of Romanian Medical Students during COVID-19 Times: From Knowledge to Behavior.

Author

Enciu, Bianca Georgiana, Păuna, Andreea Marilena, Chivu, Carmen Daniela, Săndulescu, Oana, Crispo, Anna, Diaconescu, Liliana Veronica, Drăgănescu, Anca Cristina, Crăciun, Maria-Dorina, Pițigoi, Daniela, and Aramă, Victoria

Subjects
MEDICAL students, INFLUENZA vaccines, COVID-19 pandemic, MEDICAL personnel, VACCINATION, ANTI-vaccination movement, PUBLIC health education
Abstract

In Romania, influenza vaccination uptake among healthcare workers decreased over time despite access to the vaccine being constantly improved. The aim of this paper is to provide a comparative analysis of the knowledge and attitudes of Dental Medicine and Medicine students towards recommended vaccinations for healthcare workers, focusing on influenza vaccination. A cross-sectional study was conducted during the entire 2021–2022 academic year. Data were collected using 2 electronic questionnaires which were applied to the students from the Faculty of Medicine (n = 883) and, respectively, the Faculty of Dental Medicine of the Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. The questionnaires were offered to 1187 students and completed by 911 students (response rate = 77%). Out of these, 85% (n = 778) identified the influenza vaccine as recommended; 35% (n = 321) reported getting an annual influenza vaccination; and 37% (333) reported getting an influenza vaccination in the previous season. Overall, 45% (n = 222) of the respondents who completed the questionnaires from October 2021 to February 2022 reported that they intend to get vaccinated against influenza in the 2021–2022 season and approximately 8% (n = 39) reported that they had already been vaccinated. The multivariable analysis showed that the habit of getting annually vaccinated against influenza as well as the knowledge that influenza vaccine is recommended for all healthcare workers were associated with a higher probability of intending to get vaccinated. The current study emphasizes the need to raise awareness among medical students regarding influenza vaccination and to involve medical education institutions, public health authorities, and healthcare facilities in promoting this vaccination among students since the influenza vaccine uptake rate among medical students included in this study was suboptimal. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Strategies to evaluate outcomes in long-COVID-19 and post-COVID survivors

Author

Crispo, Anna, Bimonte, Sabrina, Porciello, Giuseppe, Forte, Cira Antonietta, Cuomo, Gaia, Montagnese, Concetta, Prete, Melania, Grimaldi, Maria, Celentano, Egidio, Amore, Alfonso, de Blasio, Elvio, Pentimalli, Francesca, Giordano, Antonio, Botti, Gerardo, Baglio, Giovanni, Sileri, Pierpaolo, Cascella, Marco, and Cuomo, Arturo

Published
2021
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18. Stereotactic body radiotherapy with CyberKnife® System for low- and intermediate-risk prostate cancer: clinical outcomes and toxicities of CyPro Trial

Author

Borzillo, Valentina, primary, Scipilliti, Esmeralda, additional, Pezzulla, Donato, additional, Serra, Marcello, additional, Ametrano, Gianluca, additional, Quarto, Giuseppe, additional, Perdonà, Sisto, additional, Rossetti, Sabrina, additional, Pignata, Sandro, additional, Crispo, Anna, additional, Di Gennaro, Piergiacomo, additional, D’Alesio, Valentina, additional, Arrichiello, Cecilia, additional, Buonanno, Francesca, additional, Mercogliano, Simona, additional, Russo, Antonio, additional, Tufano, Antonio, additional, Di Franco, Rossella, additional, and Muto, Paolo, additional

Published
2023
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19. Pertinence of Salt-Related Knowledge and Reported Behaviour on Salt Intake in Adults: A Cross-Sectional Study

Author

Marakis, Georgios, primary, Marques Domingues, Ana, additional, Crispo, Anna, additional, Magriplis, Emmanuella, additional, Vasara, Eleni, additional, Kontopoulou, Lamprini, additional, Triantafyllou, Christos, additional, Skepastianos, Petros, additional, Papadopoulou, Sousana K., additional, Rodopaios, Nikolaos E., additional, Hassapidou, Maria, additional, Zampelas, Antonis, additional, Cappuccio, Francesco P., additional, and Breda, João, additional

Published
2023
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20. 1819: A RCT on lifestyle and microbiota in prostate cancer pts undergoing RT: MICROSTYLE study.

Author

Repetti, Ilaria, Marvaso, Giulia, Corrao, Giulia, Lorubbio, Chiara, Gnagnarella, Patrizia, Johansson, Harriet, Muto, Paolo, Borzillo, Valentina, Celentano, Egidio, Crispo, Anna, Pinto, Monica, Cavalcanti, Ernesta, Summa, Barbara, Labonia, Francesco, Porciello, Giuseppe, Prete, Melania, Grimaldi, Maria, D'ecclesiis, Oriana, Zerini, Dario, Di Franco, Rossella, De Martino, Nunzio, Mercogliano, G.S., Jereczek-Fossa, Barbara Alicja, and Gandini, Sara

Published
2024
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22. Central Obesity, Body Mass Index, Metabolic Syndrome and Mortality in Mediterranean Breast Cancer Patients

Author

Crispo, Anna, primary, Augustin, Livia Silvia, additional, Luongo, Assunta, additional, Calderaio, Claudia, additional, Breda, Joao, additional, Coluccia, Sergio, additional, Calabrese, Alessandra, additional, Marrazzo, Vittorio, additional, Giannatiempo, Rosa, additional, Trasacco, Paola, additional, Palumbo, Elvira, additional, Vitale, Sara, additional, Porciello, Giuseppe, additional, Gennaro, Piergiacomo Di, additional, Caputo, Roberta, additional, Buono, Giuseppe, additional, Vernieri, Claudio, additional, Schettini, Francesco, additional, Grimaldi, Maria, additional, Nocerino, Flavia, additional, Celentano, Egidio, additional, Amore, Alfonso, additional, Giuliano, Mario, additional, De Placido, Pietro, additional, De Angelis, Carmine, additional, Bianco, Roberto, additional, De Laurentiis, Michelino, additional, Vecchia, Carlo La, additional, and Arpino, Grazia, additional

Published
2023
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23. P13-004-23 Almonds and Nuts Consumption After One Year of Nutrition Counselling and Body Weight Changes in Women With Breast Cancer: An Analysis of DEDiCa Trial Data

Author

Augustin, Livia, primary, Di Gennaro, Piergiacomo, additional, Vitale, Sara, additional, Palumbo, Elvira, additional, Luongo, Assunta, additional, Porciello, Giuseppe, additional, Crispo, Anna, additional, Grimaldi, Maria, additional, Pica, Rosa, additional, Calabrese, Ilaria, additional, Riccardi, Gabriele, additional, Jenkins, David, additional, De Laurentiis, Michelino, additional, and Celentano, Egidio, additional

Published
2023
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26. Second line therapy with axitinib after only prior sunitinib in metastatic renal cell cancer: Italian multicenter real world SAX study final results

Author

Facchini, Gaetano, Rossetti, Sabrina, Berretta, Massimiliano, Cavaliere, Carla, Scagliarini, Sarah, Vitale, Maria Giuseppa, Ciccarese, Chiara, Di Lorenzo, Giuseppe, Palesandro, Erica, Conteduca, Vincenza, Basso, Umberto, Naglieri, Emanuele, Farnesi, Azzurra, Aieta, Michele, Borsellino, Nicolò, La Torre, Leonardo, Iovane, Gelsomina, Bonomi, Lucia, Gasparro, Donatello, Ricevuto, Enrico, De Tursi, Michele, De Vivo, Rocco, Lo Re, Giovanni, Grillone, Francesco, Marchetti, Paolo, De Vita, Ferdinando, Scavelli, Claudio, Sini, Claudio, Pisconti, Salvatore, Crispo, Anna, Gebbia, Vittorio, Maestri, Antonio, Galli, Luca, De Giorgi, Ugo, Iacovelli, Roberto, Buonerba, Carlo, Cartenì, Giacomo, and D’Aniello, Carmine

Published
2019
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29. One-year nutrition counselling in the context of a Mediterranean diet reduced the dietary inflammatory index in women with breast cancer: a role for the dietary glycemic index

Author

Vitale, Sara, primary, Palumbo, Elvira, additional, Polesel, Jerry, additional, Hebert, James R., additional, Shivappa, Nitin, additional, Montagnese, Concetta, additional, Porciello, Giuseppe, additional, Calabrese, Ilaria, additional, Luongo, Assunta, additional, Prete, Melania, additional, Pica, Rosa, additional, Grimaldi, Maria, additional, Crispo, Anna, additional, Esindi, Nadia, additional, Falzone, Luca, additional, Mattioli, Veronica, additional, Martinuzzo, Valentina, additional, Poletto, Luigina, additional, Cubisino, Serena, additional, Dainotta, Patrizia, additional, De Laurentiis, Michelino, additional, Pacilio, Carmen, additional, Rinaldo, Massimo, additional, Thomas, Guglielmo, additional, D'Aiuto, Massimiliano, additional, Serraino, Diego, additional, Massarut, Samuele, additional, Ferraù, Francesco, additional, Rossello, Rosalba, additional, Catalano, Francesca, additional, Banna, Giuseppe L., additional, Messina, Francesco, additional, Gatti, Davide, additional, Riccardi, Gabriele, additional, Libra, Massimo, additional, Celentano, Egidio, additional, Jenkins, David J. A., additional, and Augustin, Livia S. A., additional

Published
2023
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31. Canned Fish Consumption and Upper Digestive Tract Cancers

Author

D’Avanzo, Barbara, primary, Ardoino, Ilaria, additional, Negri, Eva, additional, Serraino, Diego, additional, Crispo, Anna, additional, Giacosa, Attilio, additional, Garavello, Werner, additional, Bravi, Francesca, additional, Turati, Federica, additional, Bosetti, Cristina, additional, Fattore, Elena, additional, La Vecchia, Carlo, additional, and Franchi, Carlotta, additional

Published
2022
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33. Survival analyses of the ZeOxaNMulti trial: Follow-up randomized, double-blinded, placebo-controlled trial of oral PMA-zeolite to prevent chemotherapy-induced side effects, especially peripheral neuropathy

Author

Vitale, Maria Giuseppa, primary, Crispo, Anna, additional, Arundine, Dario, additional, Ronga, Riccardo, additional, Barbato, Carmela, additional, Luongo, Assunta, additional, Habetswallner, Francesco, additional, De Martino, Bernardo Maria, additional, Maione, Angela, additional, Eisenwagen, Sandra, additional, Vitale, Giovanna, additional, and Riccardi, Ferdinando, additional

Published
2022
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34. Is There Indication for the Use of Biological Mesh in Cancer Patients?

Author

Patrone, Renato, primary, Leongito, Maddalena, additional, di Giacomo, Raimondo, additional, Belli, Andrea, additional, Palaia, Raffaele, additional, Amore, Alfonso, additional, Albino, Vittorio, additional, Piccirillo, Mauro, additional, Cutolo, Carmen, additional, Coluccia, Sergio, additional, Nasto, Aurelio, additional, Conzo, Giovanni, additional, Crispo, Anna, additional, Granata, Vincenza, additional, and Izzo, Francesco, additional

Published
2022
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38. Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and endometrial cancer risk: a multicentric case–control study.

Author

Esposito, Giovanna, Turati, Federica, Serraino, Diego, Crispo, Anna, Negri, Eva, Parazzini, Fabio, and La Vecchia, Carlo

Subjects
RESEARCH, LIFESTYLES, CONFIDENCE intervals, FOOD consumption, CASE-control method, DIET, RISK assessment, ENDOWMENT of research, MEDICAL protocols, PHYSICAL activity, ENDOMETRIAL tumors, DESCRIPTIVE statistics, SOCIODEMOGRAPHIC factors, BODY mass index, LOGISTIC regression analysis, DATA analysis software, ODDS ratio, MEDICAL research, DISEASE risk factors
Abstract

The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) published evidence-based recommendations for cancer prevention focusing on body weight, physical activity, and diet. Our aim is to evaluate whether adherence to the WCRF/AICR recommendations could reduce endometrial cancer risk. We used data from a multicentric, Italian hospital-based case–control study (1992–2006) including 454 endometrial cancer cases and 908 age-matched controls. Adherence to the WCRF/AICR recommendations was measured using a score (range: 0–7) based on seven components: body mass index (BMI), physical activity and five dietary items; higher scores indicated higher adherence. Odds ratios (OR) were estimated by multiple (adjusted) conditional logistic regression models including terms for major confounders and energy intake. Adherence to the WCRF/AICR recommendations was inversely related to endometrial cancer risk (OR = 0·42, 95 % confidence interval (CI) 0·30, 0·61 for the highest compared with the lowest score quartile), with a significant trend of decreasing risk with increasing adherence. An inverse association was also observed for a score including only dietary recommendations (OR = 0·67, 95 % CI 0·46, 0·96 for the highest compared with the lowest score tertile). In stratified analyses, the association was stronger among women with a normal weight, those who were older, and consequently those in post-menopause, and those with ≥ 2 children. In conclusion, high adherence to the WCRF/AICR recommendations has a favourable role in endometrial cancer risk, which is not fully explained by body weight. [ABSTRACT FROM AUTHOR]

Published
2023
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39. S02-5 Physical inactivity in nine Eastern European and Central Asian countries: results from the WHO STEPwise approach to NCD risk factor surveillance

Author

Whiting, Stephen, primary, Mendes, Romeu, additional, Abu-Omar, Karim, additional, Gelius, Peter, additional, Crispo, Anna, additional, McColl, Karen, additional, Simmonds, Phillipa, additional, Fedkina, Natalia, additional, Andreasyan, Dianne, additional, Gahraman, Hagverdiyev, additional, Migal, Tatyana, additional, Sturua, Lela, additional, Obreja, Galina, additional, Abdurakhmanova, Zulfinissio, additional, Saparkulovna, Ibraeva Nurgul, additional, Erguder, Toker, additional, Ekinci, Banu, additional, Keskinkilic, Bekir, additional, Shukurov, Shukhrat, additional, Yuldashev, Rustam, additional, Berdzuli, Nino, additional, Rakovac, Ivo, additional, and Breda, Joao, additional

Published
2022
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40. Dietary Choline and Sphingomyelin Choline moiety Intake and Risk of Colorectal Cancer: A Case Control Study

Author

Rossi, Marta, primary, Khalifeh, Malak, additional, Fiori, Federica, additional, Parpinel, Maria, additional, Serraino, Diego, additional, Pelucchi, Claudio, additional, Negri, Eva, additional, Giacosa, Attilio, additional, Crispo, Anna, additional, Collatuzzo, Giulia, additional, Hannun, Yusuf, additional, Luberto, Chiara, additional, Vecchia, Carlo La, additional, and Boffetta, Paolo, additional

Published
2022
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43. Reirradiation of Locally Recurrent Prostate Cancer with Cyberknife® System or Volumetric Modulated Arc Therapy (VMAT) and IGRT-Clarity®: Outcomes, Toxicities and Dosimetric Evaluation

Author

Di Franco, Rossella, primary, Borzillo, Valentina, additional, Scipilliti, Esmeralda, additional, Ametrano, Gianluca, additional, Serra, Marcello, additional, Arrichiello, Cecilia, additional, Savino, Federica, additional, De Martino, Fortuna, additional, D’Alesio, Valentina, additional, Cammarota, Fabrizio, additional, Crispo, Anna, additional, Pignata, Sandro, additional, Rossetti, Sabrina, additional, Quarto, Giuseppe, additional, and Muto, Paolo, additional

Published
2022
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44. Bibliometric Network Analysis on Rapid-Onset Opioids for Breakthrough Cancer Pain Treatment

Author

Cascella, Marco, primary, Monaco, Federica, additional, Nocerino, Davide, additional, Chinè, Elisabetta, additional, Carpenedo, Roberta, additional, Picerno, Paola, additional, Migliaccio, Laura, additional, Armignacco, Angela, additional, Franceschini, Giulia, additional, Coluccia, Sergio, additional, Gennaro, Piergiacomo Di, additional, Tracey, Maura C, additional, Forte, Cira A, additional, Tafuri, Mariangela, additional, Crispo, Anna, additional, Cutugno, Francesco, additional, Vittori, Alessandro, additional, Natoli, Silvia, additional, and Cuomo, Arturo, additional

Published
2022
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45. Reirradiation of locally recurrent prostate cancer with Cyber-knife® System or Volumetric Modulated Arc Therapy (VMAT) and IGRT-Clarity®: outcomes, toxicities and dosimetric evalu-ation

Author

Di Franco Rossella, Borzillo Valentina, Scipilliti Esmeralda, Ametrano Gianluca, Marcello, Serra, Arrichiello Cecilia, Federica, Savino, De Martino Fortuna, D'Alesio Valentina, Cammarota Fabrizio, Crispo Anna, Pignata Sandro, Rossetti Sabrina, Giuseppe, Quarto, and Muto Paolo

Subjects
Re-treatment, IGRT-Clarity, Radiotherapy, Prostate Cancer, VMAT, Cyberknife System
Abstract

The management of prostate cancer recurrence following external beam radiotherapy is not defined yet. Stereotaxic body re-irradiation therapy, has shown encouraging results for local and biochemical control. From April 2017 to December 2020, 29 patients with prostate cancer recurrence were collected, joining the retrospective studies CyPro (prot. 46/19 OSS) and CLARO (Prot.19/20 OSS) trials. Patients were treated with Cyberknife (CK), or VMAT (Volumetric Modulated Arc Technique) system by IGRT (Image-Guided Radiation Therapy)/Clarity. By comparing the re-irradiation of two groups, we investigated urinary (GU), rectal (GI) toxicities and biochemical control. Furthermore, we dosimetrically compared the two techniques by rival plans. The VMAT-IGRT Clarity treatments were replanned with an optimized template developed for prostate VMAT-SBRT in FFF mode keeping the dose and fractionation scheduled for CK Group at 30 Gy in 5fx, prescribing at 80% isodose. 23% of patients experiencing grade 2 acute GU and 6% grade 2 acute GI in the CK group. 17% Acute GU toxicity was recorded in the VMAT-Clarity group. 8% grade 2 late toxicity was recorded in the VMAT-Clarity group. The dosimetric analysis shows that the VMAT-FFF will allow to deliver a dose biologically equivalent than with the CK, and reduce the toxicities that could arise.

Published
2022
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46. Comorbidity patterns, family history and breast cancer risk: A latent class analysis

Author

Dalmartello, Michela, Vermunt, Jeroen, Parazzini, Fabio, Serraino, Diego, Giacosa, Attilio, Crispo, Anna, Negri, Eva, Levi, Fabio, Pelucchi, Claudio, La Vecchia, Carlo, Dalmartello, Michela, Vermunt, Jeroen, Parazzini, Fabio, Serraino, Diego, Giacosa, Attilio, Crispo, Anna, Negri, Eva, Levi, Fabio, Pelucchi, Claudio, and La Vecchia, Carlo

Abstract

Background Limited evidence exists on how the presence of multiple conditions affects breast cancer (BC) risk. Methods We used data from a network hospital-based case-control study conducted in Italy and Switzerland, including 3034 BC cases and 3392 controls. Comorbidity patterns were identified using latent class analysis on a set of specific health conditions/diseases. A multiple logistic regression model was used to derive ORs and the corresponding 95% CIs for BC according to the patterns, adjusting for several covariates. A second model was fitted including an additional effect of FH on the comorbidity patterns. Results With respect to the â € healthy' pattern, the â € metabolic disorders' one reported an OR of 1.23 (95% CI 1.02 to 1.49) and the â € breast diseases' an OR of 1.86 (95% CI 1.23 to 2.83). The remaining two patterns reported an inverse association with BC, with ORs of 0.77, significant only for the â € hysterectomy, uterine fibroids and bilateral ovariectomy'. In the second model, FH was associated with an increased risk of the â € breast diseases' pattern (OR=4.09, 95% CI 2.48 to 6.74). Non-significant increased risk of the other patterns according to FH emerged. Conclusion We identified mutually exclusive patterns of comorbidity, confirming the unfavourable role of those related to metabolic and breast disorders on the risk of BC, and the protective effect of those related to common surgical procedures. FH reported an incremented risk of all the comorbidity patterns. Impact Identifying clusters of comorbidity in patients with BC may help understand their effects and enable clinicians and policymakers to better organise patient and healthcare management.

Published
2022

47. Management of Metastatic Disease in Campania (MAMETIC): An Observational Multicenter Retrospective and Prospective Trial on Palliative Radiotherapy in an Italian Region. Study Protocol

Author

Di Franco,Rossella, Cascella,Marco, Fusco,Mario, Borzillo,Valentina, Scipilliti,Esmeralda, Ferraioli,Piera, Iannacone,Eva, De Palma,Giampaolo, Silvestro,Giustino, Gherardi,Federica, Buonopane,Sergio, Alberti,Domingo, Totaro,Giuseppe, Manzo,Roberto, Guida,Giovanna, Cuomo,Arturo, Pignata,Sandro, Di Napoli,Marilena, Rossetti,Sabrina, Celentano,Egidio, Crispo,Anna, Grimaldi,Maria, Ravo,Vincenzo, Muto,Paolo, Di Franco,Rossella, Cascella,Marco, Fusco,Mario, Borzillo,Valentina, Scipilliti,Esmeralda, Ferraioli,Piera, Iannacone,Eva, De Palma,Giampaolo, Silvestro,Giustino, Gherardi,Federica, Buonopane,Sergio, Alberti,Domingo, Totaro,Giuseppe, Manzo,Roberto, Guida,Giovanna, Cuomo,Arturo, Pignata,Sandro, Di Napoli,Marilena, Rossetti,Sabrina, Celentano,Egidio, Crispo,Anna, Grimaldi,Maria, Ravo,Vincenzo, and Muto,Paolo

Abstract

Rossella Di Franco,1 Marco Cascella,2 Mario Fusco,3 Valentina Borzillo,1 Esmeralda Scipilliti,1 Piera Ferraioli,1 Eva Iannacone,1 Giampaolo De Palma,1 Giustino Silvestro,1 Federica Gherardi,1 Sergio Buonopane,1 Domingo Alberti,1 Giuseppe Totaro,1 Roberto Manzo,1 Giovanna Guida,1 Arturo Cuomo,2 Sandro Pignata,4 Marilena Di Napoli,4 Sabrina Rossetti,4 Egidio Celentano,5 Anna Crispo,5 Maria Grimaldi,5 Vincenzo Ravo,1 Paolo Muto1 1Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italia; 2Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Napoli, Italia; 3Cancer Registry Unit, ASL Napoli 3 SUD, Napoli, Italia; 4Department of Uro-Gynecological, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italia; 5Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, ItaliaCorrespondence: Rossella Di Franco, Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italia, Email r.difranco@istitutotumori.na.itBackground: In the Italian Campania Region, 30.517 new cases of solid cancer have been diagnosed, in 2019. Of those, patients with metastatic disease are up to 20%. This class of patients is extremely diversified and copious, and the offer of radiotherapy may vary in different geographical areas within the same region. The aim of this observational multicenter retrospective and prospective trial is to evaluate the occurrence of metastatic metastatic cancer patients candidates for palliative radiotherapy in several areas of a great Italian region, the management of the disease through RT approaches, and its impact on cancer-related pain and overall HRQoL.Methods: This is a multicenter, retrospective and prospective observational investigation. The retrospective part of the study concerns all patients enrolled with a diagnosis of metastatic disease and treated in RT centers w

Published
2022

48. Predictive Comprehensive Geriatric Assessment in elderly prostate cancer patients: the prospective observational scoop trial results

Author

Della Pepa, Chiara, Cavaliere, Carla, Rossetti, Sabrina, Di Napoli, Marilena, Cecere, Sabrina C., Crispo, Anna, De Sangro, Carlo, Rossi, Emanuela, Turitto, Dino, Germano, Domenico, Iovane, Gelsomina, Berretta, Massimiliano, D’Aniello, Carmine, Pisconti, Salvatore, Maiorino, Luigi, Daniele, Bruno, Gridelli, Cesare, Pignata, Sandro, and Facchini, Gaetano

Published
2017
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50. Inverse Association between Canned Fish Consumption and Colorectal Cancer Risk: Analysis of Two Large Case–Control Studies

Author

Franchi, Carlotta, primary, Ardoino, Ilaria, additional, Bosetti, Cristina, additional, Negri, Eva, additional, Serraino, Diego, additional, Crispo, Anna, additional, Giacosa, Attilio, additional, Fattore, Elena, additional, Dolci, Alberto, additional, Bravi, Francesca, additional, Turati, Federica, additional, La Vecchia, Carlo, additional, and D’Avanzo, Barbara, additional

Published
2022
Full Text
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