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2. Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Author

Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, Malcolm, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, Mitra, Dipayan, Bhatnagar, Priya, du Plessis, Johannes, Joshi, Yogish, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, Joanne, Bhakri, Harbens, Guyler, Paul, Sinha, Devesh, Loganathan, Thayalini, Siddiqui, Amber, Siddiqui, Anwer, Coward, Lucy, Kunhunny, Swapna, Tysoe, Sharon, Orath Prabakaran, Rajalakshmi, Kelavkar, Shyam, Rashmi, Sindhu, Ngo, David, Ng, Kheng Xiong, Menon, Nisha, Shah, Sweni, Barber, Mark, Esson, Derek, Brodie, Fiona, Anjum, Talat, Wani, Mushtaq, Krishnan, Manju, Quinn, Leanne, Spencer, Jayne, Jones, Terry, Thompson-Jones, Helen, Dacey, Lynne, Chenna, Srikanth, Storton, Sharon, Thomas, Sarah, Beaty, Teresa, Treadwell, Shelley, Davies, Caroline, Tucker, Susan, Connor, Lynda, Slade, Peter, Gainard, Glyn, Muddegowda, Girish, Sanyal, Ranjan, Remegoso, Alda, Abano, Nenette, Causley, Chelsea, Carpio, Racquel, Stevens, Stephanie, Butler, Adrian, Varquez, Resti, Denic, Hayley, Alipio, Francis, Moores, Andrew, Barry, Adrian, Maguire, Holly, Grocott, Jeanette, Finney, Kay, Lyjko, Sue, Roffe, Christine, Hiden, Joanne, Ferdinand, Phillip, Cvoro, Vera, Ullah, Khalil, Chapman, Nicola, Couser, Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Sprigg, Nikola, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayanan, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, Buckle, Steve, Wallace, Rebecca, Mardania, Rina, Gray, Jane, Triscott, Claire, Nair, Anand, Greig, Jill, Rana, Pratap, Robinson, Matthew, Alam, Mohammad Irfan, Werring, David, Wilson, Duncan, Watchurst, Caroline, Brezitski, Maria, Crook, Luci, Jones, Ifan, Banaras, Azra, Patel, Krishna, Erande, Renuka, Hogan, Caroline, Hostettler, Isabel, Ashton, Amy, Feerick, Shez, Francia, Nina, Oji, Nnebuife, Elliott, Emma, Al-Mayhani, Talal, Dennis, Martin, Sudlow, Cathie, Whiteley, William, Al-Shahi Salman, Rustam, Dutta, Dipankar, Brown, Pauline, Ward, Deborah, Davis, Fiona, Turfrey, Jennifer, Hughes, Chloe, Collins, Kayleigh, Bakawala, Rehana, O'Connell, Susan, Glass, Jon, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Chapman, Kath, Young, Andrew, Bergin, Adrian, Sigsworth, Andrew, Manoj, Aravind, Fletcher, Glyn, Lopez, Paula, Cox, Penelope, Wilkinson, Mark, Fitzsimmons, Paul, Sharma, Nikhil, Choulerton, James, Button, Denise, Dow, Lindsey, Gbadamoshi, Lukuman, Avis, Joanne, Madigan, Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, Amy, Guthrie, Lucy Belle, Clarke, Samantha, Hassan, Ahamad, Waugh, Dean, Veraque, Emelda, Makawa, Linetty, Kambafwile, Mary, Randall, Marc, Papavasileiou, Vasileios, Cullen, Claire, Peters, Jenny, Thant, Hlaing, Ingram, Tanya, Zoe, Mellor, Durairaj, Ramesh, Harrison, Melanie, Stevenson, Sarah, Shackcloth, Daniela, Ewing, Jordan, Sutton, Victoria, McCarron, Mark, McKee, Jacqueline, Doherty, Mandy, McVerry, Ferghal, Blair, Caroline, MacLeod, Mary, Irvine, Janice, Gow, Heather, Furnace, Jacqueline, Joyson, Anu, Jagpal, Baljit, Ross, Sarah, Klaasen, Katrina, Nelson, Sandra, Clarke, Rebecca, Crouch, Nichola, MacLennan, Beverly, Taylor, Vicky, Epstein, Daniel, Shukla, Avani, Krishnamurthy, Vinodh, Nicholas, Paul, Qureshi, Sammie, Webber, Adam, Penge, Justin, Ramadan, Hawraman, Maguire, Stuart, Patterson, Chris, Bellfield, Ruth, Hairsine, Brigid, Stewart, Kelvin, Hooley, Michaela, Quinn, Outi, Richard, Bella, Moseley, Sally, Edwards, Mandy, Lawson, Heidi, Tayler, Michelle, Pai, Yogish, Dhakal, Mahesh, Esisi, Bernard, Dima, Sofia, Smith, Gemma Marie, Garside, Mark, Naeem, Muhammad, Baliga, Vidya, Rogers, Gill, Brown, Ellen, Bruce, David, Hayman, Rachel, Clayton, Susan, Gamble, Ed, Grue, Rebecca, Charles, Bethan, Hague, Adam, Blane, Sujata, Lambert, Caroline, Chaudhry, Afnan, Harrison, Thomas, Saastamoinen, Kari, Hove, Dionne, Howaniec, Laura, Grimwood, Gemma, Redjep, Ozlem, Humphries, Fiona, Argandona, Lucia, Cuenoud, Larissa, Erumere, Esther, Amlani, Sageet, Auld, Grace, Salek-Haddadi, Afraim, Schulz, Ursula, Kennedy, James, Ford, Gary, Mathieson, Philip, Reckless, Ian, Teal, Rachel, Lenti, Giulia, Harston, George, O'Brien, Eoin, Mcgee, Joanne, Mitchell, Jennifer, Amis, Elaine, Handley, Dominic, Kelly, Siobhan, Zachariah, George, Francis, Jobbin, Crisp, Sarah, Sesay, Juliana, Finlay, Sarah, Hayhoe, Helen, Hannon, Niamh, Hughes, Tom, Morse, Bethan, De Berker, Henry, Tallantyre, Emma, Osman, Ahmed, White, Susan, Schwarz, Stefan, Jelley, Benjamin, Yadava, Rajendra, Azhar, Khalid, Reddan, Julie, Sangombe, Mirriam, Stafford, Samantha, Fotherby, Ken, Morgan, Debbie, Baig, Farrukh, Jennings-Preece, Karla, Butler, Donna, Ahmad, Nasar, Willberry, Angela, Stevens, Angela, Rai, Baljinder, Siddegowda, Prasad, Howard, Peter, Hyatt, Lisa, Dobson, Tracey, Jarrett, David, Ponnambath, Suheil, Tandy, Jane, Harrington-Davies, Yasmin, Butler, Rebecca, James, Claire, Valentine, Stacey, Suttling, Anne, Langhorne, Peter, Kerr, Gillian, Wright, Fiona, Graham, Ruth, McAlpine, Christine, Iqbal, Mohammad Shahzad, Humphreys, Louise, Pasco, Kath, Balazikova, Olga, Nasim, Ashraf, Peixoto, Cassilda, Gallagher, Louise, Shahmehri, Shahrzad, Ghosh, Sandip, Barrie, Elizabeth, Gilmour, Danielle, Henry, Margo, Webb, Tom, Cowie, Linda, Rudenko, Hannah, McDonald, Shanni, Schumacher, Natasha, Walker, Susannah, Cosier, Tracey, Verrion, Anna, Beranova, Eva, Thomson, Audrey, Venter, Marius, Kar, Arindam, Mashate, Sheila, Harvey, Kirsten, Gardener, Léjeune, Nguyen, Vinh, Halse, Omid, Geraghty, Olivia, Hazel, Beth, Wilding, Peter, Tilley, Victoria, Cassidy, Tim, McClelland, Beverley, Bokhari, Maria, England, Timothy, Maddula, Mohana, Donnelly, Richard, Findlay, Paul, Macaden, Ashish, Shread, Ian, Barr, Charlotte, Mohd Nor, Azlisham, Brown, Claire, Persad, Nicola, Eglinton, Charlotte, Weinling, Marie, Hyams, Benjamin, Shah, Alex, Baker, John, Byrne, Anthony, McGhee, Caroline, Smart, Amanda, Copeland, Claire, Carpenter, Michael, Walker, Marion, Davey, Richard, Needle, Ann, Fathima, Razik, Bateman, Gavin, Datta, Prabal, Stanners, Andrew, Jackson, Linda, Ball, Julie, Davis, Michelle, Atkinson, Natalie, Fawcett, Michelle, Thompson, Teresa, Guy, Helen, Hogg, Valerie, Hays, Carole, Woodward, Stephen, Haque, Mohammad, Hakim, Eluzai, Symonds, Stuart, Maanoosi, Mehran, Herman, Jane, Black, Toby, Miriam, Skelton, Clarke, Caroline, Anthony, Alpha, Tribbeck, Michele, Cronin, Julie, Mead, Denise, Fennelly, Ruth, McIlmoyle, James, Dickinson, Christina, Jeffs, Carol, Anwar, Sajjad, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, OConnell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, Thomas, Kelly, Minks, David P, Rodrigues, Mark A, du Plessis, Johann C, Dennis, Martin S, Murray, Gordon D, Newby, David E, Sandercock, Peter A G, Stephen, Jacqueline, Sudlow, Cathie L M, Werring, David J, Whiteley, William N, Wardlaw, Joanna M, and White, Philip M

Published
2019
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8. Outcomes of Lymphoma and Multiple Myeloma Patients Following Inpatient Antineoplastic Treatment

Author

Rice, Mikhaila, Rudoni, Joslyn, Duco, Marissa, Zhong, Sharon, Burton, Lauren, Crisp, Sarah, Valent, Jason, Samaras, Christy J., Williams, Louis S., Khouri, Jack, Raza, Shahzad, Hill, Brian T., Winter, Allison, Dean, Robert M., Caimi, Paolo F., Pohlman, Brad, Heinly, Alexander, Kroger, Samantha, Rosic, Elizabeth, Donnelly, Katie, Carr, Tiffany, Harder, Mallory, Anwer, Faiz, and Jagadeesh, Deepa

Published
2023
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10. Glycine receptor autoantibodies disrupt inhibitory neurotransmission

Author

Crisp, Sarah J, Crisp, Sarah [0000-0002-0007-7775], and Apollo - University of Cambridge Repository

Subjects
Male, Patch-Clamp Techniques, Stiff-Person Syndrome, Synaptic Transmission, Rats, Sprague-Dawley, Immunoglobulin Fab Fragments, Receptors, Glycine, Pregnancy, Animals, Humans, Cells, Cultured, Aged, Autoantibodies, Motor Neurons, Excitatory Postsynaptic Potentials, Neural Inhibition, Middle Aged, Rats, Spinal Cord, stiff person syndrome (SPS), progressive encephalomyelitis with rigidity and myoclonus (PERM), Immunoglobulin G, Synapses, Female, glycine receptor, autoantibody
Abstract

Chloride-permeable glycine receptors have an important role in fast inhibitory neurotransmission in the spinal cord and brainstem. Human immunoglobulin G (IgG) autoantibodies to glycine receptors are found in a substantial proportion of patients with progressive encephalomyelitis with rigidity and myoclonus, and less frequently in other variants of stiff person syndrome. Demonstrating a pathogenic role of glycine receptor autoantibodies would help justify the use of immunomodulatory therapies and provide insight into the mechanisms involved. Here purified IgGs from four patients with progressive encephalomyelitis with rigidity and myoclonus or stiff person syndrome and glycine receptor autoantibodies were observed to profoundly disrupt glycinergic neurotransmission. In whole cell patch clamp recordings from cultured rat spinal motoneurons, glycinergic synaptic currents were almost completely abolished following incubation in patient IgGs. Most human autoantibodies targeting other CNS neurotransmitter receptors, such as N-methyl-D-aspartate (NMDA) receptors, affect whole cell currents only after several hours’ incubation and this effect has been shown to be the result of antibody-mediated crosslinking and internalisation of receptors. By contrast, we observed substantial reductions in glycinergic currents with all four patient IgG preparations with 15 minutes of exposure to patient IgGs. Moreover, monovalent Fab fragments generated from the purified IgG of three of the four patients also profoundly reduced glycinergic currents compared with control Fab-IgG. We conclude that human glycine receptor autoantibodies disrupt glycinergic neurotransmission, and also suggest that the pathogenic mechanisms include direct antagonistic actions on glycine receptors.

Published
2019

13. Beta-propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation

Author

Hayflick, Susan J., Kruer, Michael C., Gregory, Allison, Haack, Tobias B., Kurian, Manju A., Houlden, Henry H., Anderson, James, Boddaert, Nathalie, Sanford, Lynn, Harik, Sami I., Dandu, Vasuki H., Nardocci, Nardo, Zorzi, Giovanna, Dunaway, Todd, Tarnopolsky, Mark, Skinner, Steven, Holden, Kenton R., Frucht, Steven, Hanspal, Era, Schrander-Stumpel, Connie, Mignot, Cyril, Héron, Delphine, Saunders, Dawn E., Kaminska, Margaret, Lin, Jean-Pierre, Lascelles, Karine, Cuno, Stephan M., Meyer, Esther, Garavaglia, Barbara, Bhatia, Kailash, de Silva, Rajith, Crisp, Sarah, Lunt, Peter, Carey, Martyn, Hardy, John, Meitinger, Thomas, Prokisch, Holger, and Hogarth, Penelope

Published
2013
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14. Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial

Author

Al-Shahi Salman, Rustam, Dennis, MS, Sandercock, PAG, Sudlow, CLM, Wardlaw, JM, Whiteley, WN, Murray, GD, Stephen, J, Newby, DE, Sprigg, N, Werring, DJ, White, PM, Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, MR, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, Mitra, Dipayan, Bhatnagar, Priya, du Plessis, Johannes, Joshi, Yogish, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, Joanne, Bhakri, Harbens, Guyler, Paul, Sinha, Devesh, Loganathan, Thayalini, Siddiqui, Amber, Siddiqui, Anwer, Coward, Lucy, Kunhunny, Swapna, Tysoe, Sharon, Orath Prabakaran, Rajalakshmi, Kelavkar, Shyam, Rashmi, Sindhu, Ngo, David, Ng, Kheng Xiong, Menon, Nisha, Shah, Sweni, Barber, Mark, Esson, Derek, Brodie, Fiona, Anjum, Talat, Wani, Mushtaq, Krishnan, Manju, Quinn, Leanne, Spencer, Jayne, Jones, Terry, Thompson-Jones, Helen, Dacey, Lynne, Chenna, Srikanth, Storton, Sharon, Thomas, Sarah, Beaty, Teresa, Treadwell, Shelley, Davies, Caroline, Tucker, Susan, Connor, Lynda, Slade, Peter, Gainard, Glyn, Muddegowda, Girish, Sanyal, Ranjan, Remegoso, Alda, Abano, Nenette, Causley, Chelsea, Carpio, Racquel, Stevens, Stephanie, Butler, Adrian, Varquez, Resti, Denic, Hayley, Alipio, Francis, Moores, Andrew, Barry, Adrian, Maguire, Holly, Grocott, Jeanette, Finney, Kay, Lyjko, Sue, Roffe, Christine, Hiden, Joanne, Ferdinand, Phillip, Cvoro, Vera, Ullah, Khalil, Chapman, Nicola, Couser, Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayana, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, Buckle, Steve, Wallace, Rebecca, Mardania, Rina, Gray, Jane, Triscott, Claire, Nair, Anand, Greig, Jill, Rana, Pratap, Robinson, Matthew, Alam, Mohammad Irfan, Wilson, Duncan, Watchurst, Caroline, Brezitski, Maria, Crook, Luci, Jones, Ifan, Banaras, Azra, Patel, Krishna, Erande, Renuka, Hogan, Caroline, Hostettler, Isabel, Ashton, Amy, Feerick, Shez, Francia, Nina, Oji, Nnebuife, Elliott, Emma, Al-Mayhani, Talal, Dutta, Dipankar, Brown, Pauline, Ward, Deborah, Davis, Fiona, Turfrey, Jennifer, Hughes, Chloe, Collins, Kayleigh, Bakawala, Rehana, O'Connell, Susan, Glass, Jon, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Chapman, Kath, Young, Andrew, Bergin, Adrian, Sigsworth, Andrew, Manoj, Aravind, Fletcher, Glyn, Lopez, Paula, Cox, Penelope, Wilkinson, Mark, Fitzsimmons, Paul, Sharma, Nikhil, Choulerton, James, Button, Denise, Dow, Lindsey, Gbadamoshi, Lukuman, Avis, Joanne, Madigan, Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, Amy, Guthrie, Lucy Belle, Clarke, Samantha, Hassan, Ahamad, Waugh, Dean, Veraque, Emelda, Makawa, Linetty, Kambafwile, Mary, Randall, Marc, Papavasileiou, Vasileios, Cullen, Claire, Peters, Jenny, Thant, Hlaing, Ingram, Tanya, Zoe, Mellor, Durairaj, Ramesh, Harrison, Melanie, Stevenson, Sarah, Shackcloth, Daniela, Ewing, Jordan, Sutton, Victoria, McCarron, Mark, McKee, Jacqueline, Doherty, Mandy, McVerry, Ferghal, Blair, Caroline, MacLeod, Mary, Irvine, Janice, Gow, Heather, Furnace, Jacqueline, Joyson, Anu, Jagpal, Baljit, Ross, Sarah, Klaasen, Katrina, Nelson, Sandra, Clarke, Rebecca, Crouch, Nichola, MacLennan, Beverly, Taylor, Vicky, Epstein, Daniel, Shukla, Avani, Krishnamurthy, Vinodh, Nicholas, Paul, Qureshi, Sammie, Webber, Adam, Penge, Justin, Ramadan, Hawraman, Maguire, Stuart, Patterson, Chris, Bellfield, Ruth, Hairsine, Brigid, Stewart, Kelvin, Hooley, Michaela, Quinn, Outi, Richard, Bella, Moseley, Sally, Edwards, Mandy, Lawson, Heidi, Tayler, Michelle, Pai, Yogish, Dhakal, Mahesh, Esisi, Bernard, Dima, Sofia, Smith, Gemma Marie, Garside, Mark, Naeem, Muhammad, Baliga, Vidya, Rogers, Gill, Brown, Ellen, Bruce, David, Hayman, Rachel, Clayton, Susan, Gamble, Ed, Grue, Rebecca, Charles, Bethan, Hague, Adam, Blane, Sujata, Lambert, Caroline, Chaudhry, Afnan, Harrison, Thomas, Saastamoinen, Kari, Hove, Dionne, Howaniec, Laura, Grimwood, Gemma, Redjep, Ozlem, Humphries, Fiona, Argandona, Lucia, Cuenoud, Larissa, Erumere, Esther, Amlani, Sageet, Auld, Grace, Salek-Haddadi, Afraim, Schulz, Ursula, Kennedy, James, Ford, Gary, Mathieson, Philip, Reckless, Ian, Teal, Rachel, Lenti, Giulia, Harston, George, O'Brien, Eoin, Mcgee, Joanne, Mitchell, Jennifer, Amis, Elaine, Handley, Dominic, Kelly, Siobhan, Zachariah, George, Francis, Jobbin, Crisp, Sarah, Sesay, Juliana, Finlay, Sarah, Hayhoe, Helen, Hannon, Niamh, Hughes, Tom, Morse, Bethan, De Berker, Henry, Tallantyre, Emma, Osman, Ahmed, White, Susan, Schwarz, Stefan, Jelley, Benjamin, Yadava, Rajendra, Azhar, Khalid, Reddan, Julie, Sangombe, Mirriam, Stafford, Samantha, Fotherby, Ken, Morgan, Debbie, Baig, Farrukh, Jennings-Preece, Karla, Butler, Donna, Ahmad, Nasar, Willberry, Angela, Stevens, Angela, Rai, Baljinder, Siddegowda, Prasad, Howard, Peter, Hyatt, Lisa, Dobson, Tracey, Jarrett, David, Ponnambath, Suheil, Tandy, Jane, Harrington-Davies, Yasmin, Butler, Rebecca, James, Claire, Valentine, Stacey, Suttling, Anne, Langhorne, Peter, Kerr, Gillian, Wright, Fiona, Graham, Ruth, McAlpine, Christine, Iqbal, Mohammad Shahzad, Humphreys, Louise, Pasco, Kath, Balazikova, Olga, Nasim, Ashraf, Peixoto, Cassilda, Gallagher, Louise, Shahmehri, Shahrzad, Ghosh, Sandip, Barrie, Elizabeth, Gilmour, Danielle, Henry, Margo, Webb, Tom, Cowie, Linda, Rudenko, Hannah, McDonald, Shanni, Schumacher, Natasha, Walker, Susannah, Cosier, Tracey, Verrion, Anna, Beranova, Eva, Thomson, Audrey, Venter, Marius, Kar, Arindam, Mashate, Sheila, Harvey, Kirsten, Gardener, Léjeune, Nguyen, Vinh, Halse, Omid, Geraghty, Olivia, Hazel, Beth, Wilding, Peter, Tilley, Victoria, Cassidy, Tim, McClelland, Beverley, Bokhari, Maria, England, Timothy, Maddula, Mohana, Donnelly, Richard, Findlay, Paul, Macaden, Ashish, Shread, Ian, Barr, Charlotte, Mohd Nor, Azlisham, Brown, Claire, Persad, Nicola, Eglinton, Charlotte, Weinling, Marie, Hyams, Benjamin, Shah, Alex, Baker, John, Byrne, Anthony, McGhee, Caroline, Smart, Amanda, Copeland, Claire, Carpenter, Michael, Walker, Marion, Davey, Richard, Needle, Ann, Fathima, Razik, Bateman, Gavin, Datta, Prabal, Stanners, Andrew, Jackson, Linda, Ball, Julie, Davis, Michelle, Atkinson, Natalie, Fawcett, Michelle, Thompson, Teresa, Guy, Helen, Hogg, Valerie, Hays, Carole, Woodward, Stephen, Haque, Mohammad, Hakim, Eluzai, Symonds, Stuart, Maanoosi, Mehran, Herman, Jane, Black, Toby, Miriam, Skelton, Clarke, Caroline, Anthony, Alpha, Tribbeck, Michele, Cronin, Julie, Mead, Denise, Fennelly, Ruth, McIlmoyle, James, Dickinson, Christina, Jeffs, Carol, Anwar, Sajjad, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, O'Connell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, Kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, and Thomas, Kelly

Abstract

Background:\ud Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events.\ud \ud Methods:\ud The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial at 122 hospitals in the UK. We recruited adults (≥18 years) who were taking antithrombotic (antiplatelet or anticoagulant) therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage, discontinued antithrombotic therapy, and survived for 24 h. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. We followed participants for the primary outcome (recurrent symptomatic intracerebral haemorrhage) for up to 5 years. We analysed data from all randomised participants using Cox proportional hazards regression, adjusted for minimisation covariates. This trial is registered with ISRCTN (number ISRCTN71907627).\ud \ud Findings:\ud Between May 22, 2013, and May 31, 2018, 537 participants were recruited a median of 76 days (IQR 29–146) after intracerebral haemorrhage onset: 268 were assigned to start and 269 (one withdrew) to avoid antiplatelet therapy. Participants were followed for a median of 2·0 years (IQR [1·0– 3·0]; completeness 99·3%). 12 (4%) of 268 participants allocated to antiplatelet therapy had recurrence of intracerebral haemorrhage compared with 23 (9%) of 268 participants allocated to avoid antiplatelet therapy (adjusted hazard ratio 0·51 [95% CI 0·25–1·03]; p=0·060). 18 (7%) participants allocated to antiplatelet therapy experienced major haemorrhagic events compared with 25 (9%) participants allocated to avoid antiplatelet therapy (0·71 [0·39–1·30]; p=0·27), and 39 [15%] participants allocated to antiplatelet therapy had major occlusive vascular events compared with 38 [14%] allocated to avoid antiplatelet therapy (1·02 [0·65–1·60]; p=0·92).\ud \ud Interpretation:\ud These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention.

Published
2019

15. Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases : subgroup analyses of the RESTART randomised, open-label trial

Author

Al-Shahi Salman, Rustam, Minks, David P., Mitra, Dipayan, Rodrigues, Mark A., Bhatnagar, Priya, du Plessis, Johann C., Joshi, Yogish, Dennis, Martin, Murray, Gordon D., Newby, David E., Sandercock, Peter A.G., Sprigg, Nikola, Stephen, Jacqueline, Sudlow, Cathie, Werring, David J., Whiteley, William, Wardlaw, Joanna M., White, Philip M., Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, Malcolm, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, du Plessis, Johannes, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, Joanne, Bhakri, Harbens, Guyler, Paul, Sinha, Devesh, Loganathan, Thayalini, Siddiqui, Amber, Siddiqui, Anwer, Coward, Lucy, Kunhunny, Swapna, Tysoe, Sharon, Orath Prabakaran, Rajalakshmi, Kelavkar, Shyam, Rashmi, Sindhu, Ngo, David, Ng, Kheng Xiong, Menon, Nisha, Shah, Sweni, Barber, Mark, Esson, Derek, Brodie, Fiona, Anjum, Talat, Wani, Mushtaq, Krishnan, Manju, Quinn, Leanne, Spencer, Jayne, Jones, Terry, Thompson-Jones, Helen, Dacey, Lynne, Chenna, Srikanth, Storton, Sharon, Thomas, Sarah, Beaty, Teresa, Treadwell, Shelley, Davies, Caroline, Tucker, Susan, Connor, Lynda, Slade, Peter, Gainard, Glyn, Muddegowda, Girish, Sanyal, Ranjan, Remegoso, Alda, Abano, Nenette, Causley, Chelsea, Carpio, Racquel, Stevens, Stephanie, Butler, Adrian, Varquez, Resti, Denic, Hayley, Alipio, Francis, Moores, Andrew, Barry, Adrian, Maguire, Holly, Grocott, Jeanette, Finney, Kay, Lyjko, Sue, Roffe, Christine, Hiden, Joanne, Ferdinand, Phillip, Cvoro, Vera, Ullah, Khalil, Chapman, Nicola, Couser, Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayanan, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, Buckle, Steve, Wallace, Rebecca, Mardania, Rina, Gray, Jane, Triscott, Claire, Nair, Anand, Greig, Jill, Rana, Pratap, Robinson, Matthew, Alam, Mohammad Irfan, Werring, David, Wilson, Duncan, Watchurst, Caroline, Brezitski, Maria, Crook, Luci, Jones, Ifan, Banaras, Azra, Patel, Krishna, Erande, Renuka, Hogan, Caroline, Hostettler, Isabel, Ashton, Amy, Feerick, Shez, Francia, Nina, Oji, Nnebuife, Elliott, Emma, Al-Mayhani, Talal, Dutta, Dipankar, Brown, Pauline, Ward, Deborah, Davis, Fiona, Turfrey, Jennifer, Hughes, Chloe, Collins, Kayleigh, Bakawala, Rehana, O'Connell, Susan, Glass, Jon, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Chapman, Kath, Young, Andrew, Bergin, Adrian, Sigsworth, Andrew, Manoj, Aravind, Fletcher, Glyn, Lopez, Paula, Cox, Penelope, Wilkinson, Mark, Fitzsimmons, Paul, Sharma, Nikhil, Choulerton, James, Button, Denise, Dow, Lindsey, Gbadamoshi, Lukuman, Avis, Joanne, Madigan, Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, Amy, Guthrie, Lucy Belle, Clarke, Samantha, Hassan, Ahamad, Waugh, Dean, Veraque, Emelda, Makawa, Linetty, Kambafwile, Mary, Randall, Marc, Papavasileiou, Vasileios, Cullen, Claire, Peters, Jenny, Thant, Hlaing, Ingram, Tanya, Zoe, Mellor, Durairaj, Ramesh, Harrison, Melanie, Stevenson, Sarah, Shackcloth, Daniela, Ewing, Jordan, Sutton, Victoria, McCarron, Mark, McKee, Jacqueline, Doherty, Mandy, McVerry, Ferghal, Blair, Caroline, MacLeod, Mary, Irvine, Janice, Gow, Heather, Furnace, Jacqueline, Joyson, Anu, Jagpal, Baljit, Ross, Sarah, Klaasen, Katrina, Nelson, Sandra, Clarke, Rebecca, Crouch, Nichola, MacLennan, Beverly, Taylor, Vicky, Epstein, Daniel, Shukla, Avani, Krishnamurthy, Vinodh, Nicholas, Paul, Qureshi, Sammie, Webber, Adam, Penge, Justin, Ramadan, Hawraman, Maguire, Stuart, Patterson, Chris, Bellfield, Ruth, Hairsine, Brigid, Stewart, Kelvin, Hooley, Michaela, Quinn, Outi, Richard, Bella, Moseley, Sally, Edwards, Mandy, Lawson, Heidi, Tayler, Michelle, Pai, Yogish, Dhakal, Mahesh, Esisi, Bernard, Dima, Sofia, Smith, Gemma Marie, Garside, Mark, Naeem, Muhammad, Baliga, Vidya, Rogers, Gill, Brown, Ellen, Bruce, David, Hayman, Rachel, Clayton, Susan, Gamble, Ed, Grue, Rebecca, Charles, Bethan, Hague, Adam, Blane, Sujata, Lambert, Caroline, Chaudhry, Afnan, Harrison, Thomas, Saastamoinen, Kari, Hove, Dionne, Howaniec, Laura, Grimwood, Gemma, Redjep, Ozlem, Humphries, Fiona, Argandona, Lucia, Cuenoud, Larissa, Erumere, Esther, Amlani, Sageet, Auld, Grace, Salek-Haddadi, Afraim, Schulz, Ursula, Kennedy, James, Ford, Gary, Mathieson, Philip, Reckless, Ian, Teal, Rachel, Lenti, Giulia, Harston, George, O'Brien, Eoin, Mcgee, Joanne, Mitchell, Jennifer, Amis, Elaine, Handley, Dominic, Kelly, Siobhan, Zachariah, George, Francis, Jobbin, Crisp, Sarah, Sesay, Juliana, Finlay, Sarah, Hayhoe, Helen, Hannon, Niamh, Hughes, Tom, Morse, Bethan, De Berker, Henry, Tallantyre, Emma, Osman, Ahmed, White, Susan, Schwarz, Stefan, Jelley, Benjamin, Yadava, Rajendra, Azhar, Khalid, Reddan, Julie, Sangombe, Mirriam, Stafford, Samantha, Fotherby, Ken, Morgan, Debbie, Baig, Farrukh, Jennings-Preece, Karla, Butler, Donna, Ahmad, Nasar, Willberry, Angela, Stevens, Angela, Rai, Baljinder, Siddegowda, Prasad, Howard, Peter, Hyatt, Lisa, Dobson, Tracey, Jarrett, David, Ponnambath, Suheil, Tandy, Jane, Harrington-Davies, Yasmin, Butler, Rebecca, James, Claire, Valentine, Stacey, Suttling, Anne, Langhorne, Peter, Kerr, Gillian, Wright, Fiona, Graham, Ruth, McAlpine, Christine, Iqbal, Mohammad Shahzad, Humphreys, Louise, Pasco, Kath, Balazikova, Olga, Nasim, Ashraf, Peixoto, Cassilda, Gallagher, Louise, Shahmehri, Shahrzad, Ghosh, Sandip, Barrie, Elizabeth, Gilmour, Danielle, Henry, Margo, Webb, Tom, Cowie, Linda, Rudenko, Hannah, McDonald, Shanni, Schumacher, Natasha, Walker, Susannah, Cosier, Tracey, Verrion, Anna, Beranova, Eva, Thomson, Audrey, Venter, Marius, Kar, Arindam, Mashate, Sheila, Harvey, Kirsten, Gardener, Léjeune, Nguyen, Vinh, Halse, Omid, Geraghty, Olivia, Hazel, Beth, Wilding, Peter, Tilley, Victoria, Cassidy, Tim, McClelland, Beverley, Bokhari, Maria, England, Timothy, Maddula, Mohana, Donnelly, Richard, Findlay, Paul, Macaden, Ashish, Shread, Ian, Barr, Charlotte, Mohd Nor, Azlisham, Brown, Claire, Persad, Nicola, Eglinton, Charlotte, Weinling, Marie, Hyams, Benjamin, Shah, Alex, Baker, John, Byrne, Anthony, McGhee, Caroline, Smart, Amanda, Copeland, Claire, Carpenter, Michael, Walker, Marion, Davey, Richard, Needle, Ann, Fathima, Razik, Bateman, Gavin, Datta, Prabal, Stanners, Andrew, Jackson, Linda, Ball, Julie, Davis, Michelle, Atkinson, Natalie, Fawcett, Michelle, Thompson, Teresa, Guy, Helen, Hogg, Valerie, Hays, Carole, Woodward, Stephen, Haque, Mohammad, Hakim, Eluzai, Symonds, Stuart, Maanoosi, Mehran, Herman, Jane, Black, Toby, Miriam, Skelton, Clarke, Caroline, Anthony, Alpha, Tribbeck, Michele, Cronin, Julie, Mead, Denise, Fennelly, Ruth, McIlmoyle, James, Dickinson, Christina, Jeffs, Carol, Anwar, Sajjad, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, OConnell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, Thomas, Kelly, Al-Shahi Salman, Rustam, Minks, David P., Mitra, Dipayan, Rodrigues, Mark A., Bhatnagar, Priya, du Plessis, Johann C., Joshi, Yogish, Dennis, Martin, Murray, Gordon D., Newby, David E., Sandercock, Peter A.G., Sprigg, Nikola, Stephen, Jacqueline, Sudlow, Cathie, Werring, David J., Whiteley, William, Wardlaw, Joanna M., White, Philip M., Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, Malcolm, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, du Plessis, Johannes, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, Joanne, Bhakri, Harbens, Guyler, Paul, Sinha, Devesh, Loganathan, Thayalini, Siddiqui, Amber, Siddiqui, Anwer, Coward, Lucy, Kunhunny, Swapna, Tysoe, Sharon, Orath Prabakaran, Rajalakshmi, Kelavkar, Shyam, Rashmi, Sindhu, Ngo, David, Ng, Kheng Xiong, Menon, Nisha, Shah, Sweni, Barber, Mark, Esson, Derek, Brodie, Fiona, Anjum, Talat, Wani, Mushtaq, Krishnan, Manju, Quinn, Leanne, Spencer, Jayne, Jones, Terry, Thompson-Jones, Helen, Dacey, Lynne, Chenna, Srikanth, Storton, Sharon, Thomas, Sarah, Beaty, Teresa, Treadwell, Shelley, Davies, Caroline, Tucker, Susan, Connor, Lynda, Slade, Peter, Gainard, Glyn, Muddegowda, Girish, Sanyal, Ranjan, Remegoso, Alda, Abano, Nenette, Causley, Chelsea, Carpio, Racquel, Stevens, Stephanie, Butler, Adrian, Varquez, Resti, Denic, Hayley, Alipio, Francis, Moores, Andrew, Barry, Adrian, Maguire, Holly, Grocott, Jeanette, Finney, Kay, Lyjko, Sue, Roffe, Christine, Hiden, Joanne, Ferdinand, Phillip, Cvoro, Vera, Ullah, Khalil, Chapman, Nicola, Couser, Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayanan, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, Buckle, Steve, Wallace, Rebecca, Mardania, Rina, Gray, Jane, Triscott, Claire, Nair, Anand, Greig, Jill, Rana, Pratap, Robinson, Matthew, Alam, Mohammad Irfan, Werring, David, Wilson, Duncan, Watchurst, Caroline, Brezitski, Maria, Crook, Luci, Jones, Ifan, Banaras, Azra, Patel, Krishna, Erande, Renuka, Hogan, Caroline, Hostettler, Isabel, Ashton, Amy, Feerick, Shez, Francia, Nina, Oji, Nnebuife, Elliott, Emma, Al-Mayhani, Talal, Dutta, Dipankar, Brown, Pauline, Ward, Deborah, Davis, Fiona, Turfrey, Jennifer, Hughes, Chloe, Collins, Kayleigh, Bakawala, Rehana, O'Connell, Susan, Glass, Jon, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Chapman, Kath, Young, Andrew, Bergin, Adrian, Sigsworth, Andrew, Manoj, Aravind, Fletcher, Glyn, Lopez, Paula, Cox, Penelope, Wilkinson, Mark, Fitzsimmons, Paul, Sharma, Nikhil, Choulerton, James, Button, Denise, Dow, Lindsey, Gbadamoshi, Lukuman, Avis, Joanne, Madigan, Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, Amy, Guthrie, Lucy Belle, Clarke, Samantha, Hassan, Ahamad, Waugh, Dean, Veraque, Emelda, Makawa, Linetty, Kambafwile, Mary, Randall, Marc, Papavasileiou, Vasileios, Cullen, Claire, Peters, Jenny, Thant, Hlaing, Ingram, Tanya, Zoe, Mellor, Durairaj, Ramesh, Harrison, Melanie, Stevenson, Sarah, Shackcloth, Daniela, Ewing, Jordan, Sutton, Victoria, McCarron, Mark, McKee, Jacqueline, Doherty, Mandy, McVerry, Ferghal, Blair, Caroline, MacLeod, Mary, Irvine, Janice, Gow, Heather, Furnace, Jacqueline, Joyson, Anu, Jagpal, Baljit, Ross, Sarah, Klaasen, Katrina, Nelson, Sandra, Clarke, Rebecca, Crouch, Nichola, MacLennan, Beverly, Taylor, Vicky, Epstein, Daniel, Shukla, Avani, Krishnamurthy, Vinodh, Nicholas, Paul, Qureshi, Sammie, Webber, Adam, Penge, Justin, Ramadan, Hawraman, Maguire, Stuart, Patterson, Chris, Bellfield, Ruth, Hairsine, Brigid, Stewart, Kelvin, Hooley, Michaela, Quinn, Outi, Richard, Bella, Moseley, Sally, Edwards, Mandy, Lawson, Heidi, Tayler, Michelle, Pai, Yogish, Dhakal, Mahesh, Esisi, Bernard, Dima, Sofia, Smith, Gemma Marie, Garside, Mark, Naeem, Muhammad, Baliga, Vidya, Rogers, Gill, Brown, Ellen, Bruce, David, Hayman, Rachel, Clayton, Susan, Gamble, Ed, Grue, Rebecca, Charles, Bethan, Hague, Adam, Blane, Sujata, Lambert, Caroline, Chaudhry, Afnan, Harrison, Thomas, Saastamoinen, Kari, Hove, Dionne, Howaniec, Laura, Grimwood, Gemma, Redjep, Ozlem, Humphries, Fiona, Argandona, Lucia, Cuenoud, Larissa, Erumere, Esther, Amlani, Sageet, Auld, Grace, Salek-Haddadi, Afraim, Schulz, Ursula, Kennedy, James, Ford, Gary, Mathieson, Philip, Reckless, Ian, Teal, Rachel, Lenti, Giulia, Harston, George, O'Brien, Eoin, Mcgee, Joanne, Mitchell, Jennifer, Amis, Elaine, Handley, Dominic, Kelly, Siobhan, Zachariah, George, Francis, Jobbin, Crisp, Sarah, Sesay, Juliana, Finlay, Sarah, Hayhoe, Helen, Hannon, Niamh, Hughes, Tom, Morse, Bethan, De Berker, Henry, Tallantyre, Emma, Osman, Ahmed, White, Susan, Schwarz, Stefan, Jelley, Benjamin, Yadava, Rajendra, Azhar, Khalid, Reddan, Julie, Sangombe, Mirriam, Stafford, Samantha, Fotherby, Ken, Morgan, Debbie, Baig, Farrukh, Jennings-Preece, Karla, Butler, Donna, Ahmad, Nasar, Willberry, Angela, Stevens, Angela, Rai, Baljinder, Siddegowda, Prasad, Howard, Peter, Hyatt, Lisa, Dobson, Tracey, Jarrett, David, Ponnambath, Suheil, Tandy, Jane, Harrington-Davies, Yasmin, Butler, Rebecca, James, Claire, Valentine, Stacey, Suttling, Anne, Langhorne, Peter, Kerr, Gillian, Wright, Fiona, Graham, Ruth, McAlpine, Christine, Iqbal, Mohammad Shahzad, Humphreys, Louise, Pasco, Kath, Balazikova, Olga, Nasim, Ashraf, Peixoto, Cassilda, Gallagher, Louise, Shahmehri, Shahrzad, Ghosh, Sandip, Barrie, Elizabeth, Gilmour, Danielle, Henry, Margo, Webb, Tom, Cowie, Linda, Rudenko, Hannah, McDonald, Shanni, Schumacher, Natasha, Walker, Susannah, Cosier, Tracey, Verrion, Anna, Beranova, Eva, Thomson, Audrey, Venter, Marius, Kar, Arindam, Mashate, Sheila, Harvey, Kirsten, Gardener, Léjeune, Nguyen, Vinh, Halse, Omid, Geraghty, Olivia, Hazel, Beth, Wilding, Peter, Tilley, Victoria, Cassidy, Tim, McClelland, Beverley, Bokhari, Maria, England, Timothy, Maddula, Mohana, Donnelly, Richard, Findlay, Paul, Macaden, Ashish, Shread, Ian, Barr, Charlotte, Mohd Nor, Azlisham, Brown, Claire, Persad, Nicola, Eglinton, Charlotte, Weinling, Marie, Hyams, Benjamin, Shah, Alex, Baker, John, Byrne, Anthony, McGhee, Caroline, Smart, Amanda, Copeland, Claire, Carpenter, Michael, Walker, Marion, Davey, Richard, Needle, Ann, Fathima, Razik, Bateman, Gavin, Datta, Prabal, Stanners, Andrew, Jackson, Linda, Ball, Julie, Davis, Michelle, Atkinson, Natalie, Fawcett, Michelle, Thompson, Teresa, Guy, Helen, Hogg, Valerie, Hays, Carole, Woodward, Stephen, Haque, Mohammad, Hakim, Eluzai, Symonds, Stuart, Maanoosi, Mehran, Herman, Jane, Black, Toby, Miriam, Skelton, Clarke, Caroline, Anthony, Alpha, Tribbeck, Michele, Cronin, Julie, Mead, Denise, Fennelly, Ruth, McIlmoyle, James, Dickinson, Christina, Jeffs, Carol, Anwar, Sajjad, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, OConnell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, and Thomas, Kelly

Published
2019

16. Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Author

Neurologie, Brain, Circulatory Health, Al-Shahi Salman, Rustam, Minks, David P., Mitra, Dipayan, Rodrigues, Mark A., Bhatnagar, Priya, du Plessis, Johann C., Joshi, Yogish, Dennis, Martin, Murray, Gordon D., Newby, David E., Sandercock, Peter A.G., Sprigg, Nikola, Stephen, Jacqueline, Sudlow, Cathie, Werring, David J., Whiteley, William, Wardlaw, Joanna M., White, Philip M., Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, Malcolm, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, du Plessis, Johannes, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, Joanne, Bhakri, Harbens, Guyler, Paul, Sinha, Devesh, Loganathan, Thayalini, Siddiqui, Amber, Siddiqui, Anwer, Coward, Lucy, Kunhunny, Swapna, Tysoe, Sharon, Orath Prabakaran, Rajalakshmi, Kelavkar, Shyam, Rashmi, Sindhu, Ngo, David, Ng, Kheng Xiong, Menon, Nisha, Shah, Sweni, Barber, Mark, Esson, Derek, Brodie, Fiona, Anjum, Talat, Wani, Mushtaq, Krishnan, Manju, Quinn, Leanne, Spencer, Jayne, Jones, Terry, Thompson-Jones, Helen, Dacey, Lynne, Chenna, Srikanth, Storton, Sharon, Thomas, Sarah, Beaty, Teresa, Treadwell, Shelley, Davies, Caroline, Tucker, Susan, Connor, Lynda, Slade, Peter, Gainard, Glyn, Muddegowda, Girish, Sanyal, Ranjan, Remegoso, Alda, Abano, Nenette, Causley, Chelsea, Carpio, Racquel, Stevens, Stephanie, Butler, Adrian, Varquez, Resti, Denic, Hayley, Alipio, Francis, Moores, Andrew, Barry, Adrian, Maguire, Holly, Grocott, Jeanette, Finney, Kay, Lyjko, Sue, Roffe, Christine, Hiden, Joanne, Ferdinand, Phillip, Cvoro, Vera, Ullah, Khalil, Chapman, Nicola, Couser, Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayanan, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, Buckle, Steve, Wallace, Rebecca, Mardania, Rina, Gray, Jane, Triscott, Claire, Nair, Anand, Greig, Jill, Rana, Pratap, Robinson, Matthew, Alam, Mohammad Irfan, Werring, David, Wilson, Duncan, Watchurst, Caroline, Brezitski, Maria, Crook, Luci, Jones, Ifan, Banaras, Azra, Patel, Krishna, Erande, Renuka, Hogan, Caroline, Hostettler, Isabel, Ashton, Amy, Feerick, Shez, Francia, Nina, Oji, Nnebuife, Elliott, Emma, Al-Mayhani, Talal, Dutta, Dipankar, Brown, Pauline, Ward, Deborah, Davis, Fiona, Turfrey, Jennifer, Hughes, Chloe, Collins, Kayleigh, Bakawala, Rehana, O'Connell, Susan, Glass, Jon, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Chapman, Kath, Young, Andrew, Bergin, Adrian, Sigsworth, Andrew, Manoj, Aravind, Fletcher, Glyn, Lopez, Paula, Cox, Penelope, Wilkinson, Mark, Fitzsimmons, Paul, Sharma, Nikhil, Choulerton, James, Button, Denise, Dow, Lindsey, Gbadamoshi, Lukuman, Avis, Joanne, Madigan, Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, Amy, Guthrie, Lucy Belle, Clarke, Samantha, Hassan, Ahamad, Waugh, Dean, Veraque, Emelda, Makawa, Linetty, Kambafwile, Mary, Randall, Marc, Papavasileiou, Vasileios, Cullen, Claire, Peters, Jenny, Thant, Hlaing, Ingram, Tanya, Zoe, Mellor, Durairaj, Ramesh, Harrison, Melanie, Stevenson, Sarah, Shackcloth, Daniela, Ewing, Jordan, Sutton, Victoria, McCarron, Mark, McKee, Jacqueline, Doherty, Mandy, McVerry, Ferghal, Blair, Caroline, MacLeod, Mary, Irvine, Janice, Gow, Heather, Furnace, Jacqueline, Joyson, Anu, Jagpal, Baljit, Ross, Sarah, Klaasen, Katrina, Nelson, Sandra, Clarke, Rebecca, Crouch, Nichola, MacLennan, Beverly, Taylor, Vicky, Epstein, Daniel, Shukla, Avani, Krishnamurthy, Vinodh, Nicholas, Paul, Qureshi, Sammie, Webber, Adam, Penge, Justin, Ramadan, Hawraman, Maguire, Stuart, Patterson, Chris, Bellfield, Ruth, Hairsine, Brigid, Stewart, Kelvin, Hooley, Michaela, Quinn, Outi, Richard, Bella, Moseley, Sally, Edwards, Mandy, Lawson, Heidi, Tayler, Michelle, Pai, Yogish, Dhakal, Mahesh, Esisi, Bernard, Dima, Sofia, Smith, Gemma Marie, Garside, Mark, Naeem, Muhammad, Baliga, Vidya, Rogers, Gill, Brown, Ellen, Bruce, David, Hayman, Rachel, Clayton, Susan, Gamble, Ed, Grue, Rebecca, Charles, Bethan, Hague, Adam, Blane, Sujata, Lambert, Caroline, Chaudhry, Afnan, Harrison, Thomas, Saastamoinen, Kari, Hove, Dionne, Howaniec, Laura, Grimwood, Gemma, Redjep, Ozlem, Humphries, Fiona, Argandona, Lucia, Cuenoud, Larissa, Erumere, Esther, Amlani, Sageet, Auld, Grace, Salek-Haddadi, Afraim, Schulz, Ursula, Kennedy, James, Ford, Gary, Mathieson, Philip, Reckless, Ian, Teal, Rachel, Lenti, Giulia, Harston, George, O'Brien, Eoin, Mcgee, Joanne, Mitchell, Jennifer, Amis, Elaine, Handley, Dominic, Kelly, Siobhan, Zachariah, George, Francis, Jobbin, Crisp, Sarah, Sesay, Juliana, Finlay, Sarah, Hayhoe, Helen, Hannon, Niamh, Hughes, Tom, Morse, Bethan, De Berker, Henry, Tallantyre, Emma, Osman, Ahmed, White, Susan, Schwarz, Stefan, Jelley, Benjamin, Yadava, Rajendra, Azhar, Khalid, Reddan, Julie, Sangombe, Mirriam, Stafford, Samantha, Fotherby, Ken, Morgan, Debbie, Baig, Farrukh, Jennings-Preece, Karla, Butler, Donna, Ahmad, Nasar, Willberry, Angela, Stevens, Angela, Rai, Baljinder, Siddegowda, Prasad, Howard, Peter, Hyatt, Lisa, Dobson, Tracey, Jarrett, David, Ponnambath, Suheil, Tandy, Jane, Harrington-Davies, Yasmin, Butler, Rebecca, James, Claire, Valentine, Stacey, Suttling, Anne, Langhorne, Peter, Kerr, Gillian, Wright, Fiona, Graham, Ruth, McAlpine, Christine, Iqbal, Mohammad Shahzad, Humphreys, Louise, Pasco, Kath, Balazikova, Olga, Nasim, Ashraf, Peixoto, Cassilda, Gallagher, Louise, Shahmehri, Shahrzad, Ghosh, Sandip, Barrie, Elizabeth, Gilmour, Danielle, Henry, Margo, Webb, Tom, Cowie, Linda, Rudenko, Hannah, McDonald, Shanni, Schumacher, Natasha, Walker, Susannah, Cosier, Tracey, Verrion, Anna, Beranova, Eva, Thomson, Audrey, Venter, Marius, Kar, Arindam, Mashate, Sheila, Harvey, Kirsten, Gardener, Léjeune, Nguyen, Vinh, Halse, Omid, Geraghty, Olivia, Hazel, Beth, Wilding, Peter, Tilley, Victoria, Cassidy, Tim, McClelland, Beverley, Bokhari, Maria, England, Timothy, Maddula, Mohana, Donnelly, Richard, Findlay, Paul, Macaden, Ashish, Shread, Ian, Barr, Charlotte, Mohd Nor, Azlisham, Brown, Claire, Persad, Nicola, Eglinton, Charlotte, Weinling, Marie, Hyams, Benjamin, Shah, Alex, Baker, John, Byrne, Anthony, McGhee, Caroline, Smart, Amanda, Copeland, Claire, Carpenter, Michael, Walker, Marion, Davey, Richard, Needle, Ann, Fathima, Razik, Bateman, Gavin, Datta, Prabal, Stanners, Andrew, Jackson, Linda, Ball, Julie, Davis, Michelle, Atkinson, Natalie, Fawcett, Michelle, Thompson, Teresa, Guy, Helen, Hogg, Valerie, Hays, Carole, Woodward, Stephen, Haque, Mohammad, Hakim, Eluzai, Symonds, Stuart, Maanoosi, Mehran, Herman, Jane, Black, Toby, Miriam, Skelton, Clarke, Caroline, Anthony, Alpha, Tribbeck, Michele, Cronin, Julie, Mead, Denise, Fennelly, Ruth, McIlmoyle, James, Dickinson, Christina, Jeffs, Carol, Anwar, Sajjad, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, OConnell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, Thomas, Kelly, Neurologie, Brain, Circulatory Health, Al-Shahi Salman, Rustam, Minks, David P., Mitra, Dipayan, Rodrigues, Mark A., Bhatnagar, Priya, du Plessis, Johann C., Joshi, Yogish, Dennis, Martin, Murray, Gordon D., Newby, David E., Sandercock, Peter A.G., Sprigg, Nikola, Stephen, Jacqueline, Sudlow, Cathie, Werring, David J., Whiteley, William, Wardlaw, Joanna M., White, Philip M., Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, Malcolm, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, du Plessis, Johannes, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, Joanne, Bhakri, Harbens, Guyler, Paul, Sinha, Devesh, Loganathan, Thayalini, Siddiqui, Amber, Siddiqui, Anwer, Coward, Lucy, Kunhunny, Swapna, Tysoe, Sharon, Orath Prabakaran, Rajalakshmi, Kelavkar, Shyam, Rashmi, Sindhu, Ngo, David, Ng, Kheng Xiong, Menon, Nisha, Shah, Sweni, Barber, Mark, Esson, Derek, Brodie, Fiona, Anjum, Talat, Wani, Mushtaq, Krishnan, Manju, Quinn, Leanne, Spencer, Jayne, Jones, Terry, Thompson-Jones, Helen, Dacey, Lynne, Chenna, Srikanth, Storton, Sharon, Thomas, Sarah, Beaty, Teresa, Treadwell, Shelley, Davies, Caroline, Tucker, Susan, Connor, Lynda, Slade, Peter, Gainard, Glyn, Muddegowda, Girish, Sanyal, Ranjan, Remegoso, Alda, Abano, Nenette, Causley, Chelsea, Carpio, Racquel, Stevens, Stephanie, Butler, Adrian, Varquez, Resti, Denic, Hayley, Alipio, Francis, Moores, Andrew, Barry, Adrian, Maguire, Holly, Grocott, Jeanette, Finney, Kay, Lyjko, Sue, Roffe, Christine, Hiden, Joanne, Ferdinand, Phillip, Cvoro, Vera, Ullah, Khalil, Chapman, Nicola, Couser, Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayanan, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, Buckle, Steve, Wallace, Rebecca, Mardania, Rina, Gray, Jane, Triscott, Claire, Nair, Anand, Greig, Jill, Rana, Pratap, Robinson, Matthew, Alam, Mohammad Irfan, Werring, David, Wilson, Duncan, Watchurst, Caroline, Brezitski, Maria, Crook, Luci, Jones, Ifan, Banaras, Azra, Patel, Krishna, Erande, Renuka, Hogan, Caroline, Hostettler, Isabel, Ashton, Amy, Feerick, Shez, Francia, Nina, Oji, Nnebuife, Elliott, Emma, Al-Mayhani, Talal, Dutta, Dipankar, Brown, Pauline, Ward, Deborah, Davis, Fiona, Turfrey, Jennifer, Hughes, Chloe, Collins, Kayleigh, Bakawala, Rehana, O'Connell, Susan, Glass, Jon, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Chapman, Kath, Young, Andrew, Bergin, Adrian, Sigsworth, Andrew, Manoj, Aravind, Fletcher, Glyn, Lopez, Paula, Cox, Penelope, Wilkinson, Mark, Fitzsimmons, Paul, Sharma, Nikhil, Choulerton, James, Button, Denise, Dow, Lindsey, Gbadamoshi, Lukuman, Avis, Joanne, Madigan, Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, Amy, Guthrie, Lucy Belle, Clarke, Samantha, Hassan, Ahamad, Waugh, Dean, Veraque, Emelda, Makawa, Linetty, Kambafwile, Mary, Randall, Marc, Papavasileiou, Vasileios, Cullen, Claire, Peters, Jenny, Thant, Hlaing, Ingram, Tanya, Zoe, Mellor, Durairaj, Ramesh, Harrison, Melanie, Stevenson, Sarah, Shackcloth, Daniela, Ewing, Jordan, Sutton, Victoria, McCarron, Mark, McKee, Jacqueline, Doherty, Mandy, McVerry, Ferghal, Blair, Caroline, MacLeod, Mary, Irvine, Janice, Gow, Heather, Furnace, Jacqueline, Joyson, Anu, Jagpal, Baljit, Ross, Sarah, Klaasen, Katrina, Nelson, Sandra, Clarke, Rebecca, Crouch, Nichola, MacLennan, Beverly, Taylor, Vicky, Epstein, Daniel, Shukla, Avani, Krishnamurthy, Vinodh, Nicholas, Paul, Qureshi, Sammie, Webber, Adam, Penge, Justin, Ramadan, Hawraman, Maguire, Stuart, Patterson, Chris, Bellfield, Ruth, Hairsine, Brigid, Stewart, Kelvin, Hooley, Michaela, Quinn, Outi, Richard, Bella, Moseley, Sally, Edwards, Mandy, Lawson, Heidi, Tayler, Michelle, Pai, Yogish, Dhakal, Mahesh, Esisi, Bernard, Dima, Sofia, Smith, Gemma Marie, Garside, Mark, Naeem, Muhammad, Baliga, Vidya, Rogers, Gill, Brown, Ellen, Bruce, David, Hayman, Rachel, Clayton, Susan, Gamble, Ed, Grue, Rebecca, Charles, Bethan, Hague, Adam, Blane, Sujata, Lambert, Caroline, Chaudhry, Afnan, Harrison, Thomas, Saastamoinen, Kari, Hove, Dionne, Howaniec, Laura, Grimwood, Gemma, Redjep, Ozlem, Humphries, Fiona, Argandona, Lucia, Cuenoud, Larissa, Erumere, Esther, Amlani, Sageet, Auld, Grace, Salek-Haddadi, Afraim, Schulz, Ursula, Kennedy, James, Ford, Gary, Mathieson, Philip, Reckless, Ian, Teal, Rachel, Lenti, Giulia, Harston, George, O'Brien, Eoin, Mcgee, Joanne, Mitchell, Jennifer, Amis, Elaine, Handley, Dominic, Kelly, Siobhan, Zachariah, George, Francis, Jobbin, Crisp, Sarah, Sesay, Juliana, Finlay, Sarah, Hayhoe, Helen, Hannon, Niamh, Hughes, Tom, Morse, Bethan, De Berker, Henry, Tallantyre, Emma, Osman, Ahmed, White, Susan, Schwarz, Stefan, Jelley, Benjamin, Yadava, Rajendra, Azhar, Khalid, Reddan, Julie, Sangombe, Mirriam, Stafford, Samantha, Fotherby, Ken, Morgan, Debbie, Baig, Farrukh, Jennings-Preece, Karla, Butler, Donna, Ahmad, Nasar, Willberry, Angela, Stevens, Angela, Rai, Baljinder, Siddegowda, Prasad, Howard, Peter, Hyatt, Lisa, Dobson, Tracey, Jarrett, David, Ponnambath, Suheil, Tandy, Jane, Harrington-Davies, Yasmin, Butler, Rebecca, James, Claire, Valentine, Stacey, Suttling, Anne, Langhorne, Peter, Kerr, Gillian, Wright, Fiona, Graham, Ruth, McAlpine, Christine, Iqbal, Mohammad Shahzad, Humphreys, Louise, Pasco, Kath, Balazikova, Olga, Nasim, Ashraf, Peixoto, Cassilda, Gallagher, Louise, Shahmehri, Shahrzad, Ghosh, Sandip, Barrie, Elizabeth, Gilmour, Danielle, Henry, Margo, Webb, Tom, Cowie, Linda, Rudenko, Hannah, McDonald, Shanni, Schumacher, Natasha, Walker, Susannah, Cosier, Tracey, Verrion, Anna, Beranova, Eva, Thomson, Audrey, Venter, Marius, Kar, Arindam, Mashate, Sheila, Harvey, Kirsten, Gardener, Léjeune, Nguyen, Vinh, Halse, Omid, Geraghty, Olivia, Hazel, Beth, Wilding, Peter, Tilley, Victoria, Cassidy, Tim, McClelland, Beverley, Bokhari, Maria, England, Timothy, Maddula, Mohana, Donnelly, Richard, Findlay, Paul, Macaden, Ashish, Shread, Ian, Barr, Charlotte, Mohd Nor, Azlisham, Brown, Claire, Persad, Nicola, Eglinton, Charlotte, Weinling, Marie, Hyams, Benjamin, Shah, Alex, Baker, John, Byrne, Anthony, McGhee, Caroline, Smart, Amanda, Copeland, Claire, Carpenter, Michael, Walker, Marion, Davey, Richard, Needle, Ann, Fathima, Razik, Bateman, Gavin, Datta, Prabal, Stanners, Andrew, Jackson, Linda, Ball, Julie, Davis, Michelle, Atkinson, Natalie, Fawcett, Michelle, Thompson, Teresa, Guy, Helen, Hogg, Valerie, Hays, Carole, Woodward, Stephen, Haque, Mohammad, Hakim, Eluzai, Symonds, Stuart, Maanoosi, Mehran, Herman, Jane, Black, Toby, Miriam, Skelton, Clarke, Caroline, Anthony, Alpha, Tribbeck, Michele, Cronin, Julie, Mead, Denise, Fennelly, Ruth, McIlmoyle, James, Dickinson, Christina, Jeffs, Carol, Anwar, Sajjad, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, OConnell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, and Thomas, Kelly

Published
2019

19. Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Author

Al-Shahi Salman, Rustam, primary, Minks, David P, additional, Mitra, Dipayan, additional, Rodrigues, Mark A, additional, Bhatnagar, Priya, additional, du Plessis, Johann C, additional, Joshi, Yogish, additional, Dennis, Martin S, additional, Murray, Gordon D, additional, Newby, David E, additional, Sandercock, Peter A G, additional, Sprigg, Nikola, additional, Stephen, Jacqueline, additional, Sudlow, Cathie L M, additional, Werring, David J, additional, Whiteley, William N, additional, Wardlaw, Joanna M, additional, White, Philip M, additional, Baigent, Colin, additional, Lasserson, Daniel, additional, Sullivan, Frank, additional, Carrie, Johanna, additional, Rojas, Javier, additional, Amoils, Shannon, additional, Bamford, John, additional, Armitage, Jane, additional, Rinkel, Gabriel, additional, Lowe, Gordon, additional, Emberson, Jonathan, additional, Innes, Karen, additional, Dinsmore, Lynn, additional, Drever, Jonathan, additional, Williams, Carol, additional, Perry, David, additional, McGill, Connor, additional, Buchanan, David, additional, Walker, Allan, additional, Hutchison, Aidan, additional, Matthews, Christopher, additional, Fraser, Ruth, additional, McGrath, Aileen, additional, Deary, Ann, additional, Anderson, Rosemary, additional, Walker, Pauli, additional, Hansen, Christian, additional, Parker, Richard, additional, Rodriguez, Aryelly, additional, Macleod, Malcolm, additional, Gattringer, Thomas, additional, Palmer, Jeb, additional, Sakka, Eleni, additional, Adil-Smith, Jennifer, additional, Minks, David, additional, du Plessis, Johannes, additional, Lerpiniere, Christine, additional, O'Brien, Richard, additional, Burgess, Seona, additional, Mead, Gillian, additional, Paulton, Ruth, additional, Doubal, Fergus, additional, McCormick, Katrina, additional, Hunter, Neil, additional, Taylor, Pat, additional, Parakramawansha, Ruwan, additional, Perry, Jack, additional, Blair, Gordon, additional, MacRaild, Allan, additional, Parry-Jones, Adrian, additional, Johnes, Mary, additional, Lee, Stephanie, additional, Shaw, Kelly Marie, additional, Burger, Ilse, additional, Punter, Martin, additional, Ingham, Andrea, additional, Perez, Jane, additional, Naing, Zin, additional, Morell, Jordi, additional, Marsden, Tracy, additional, Hall, Andrea, additional, Marshall, Sally, additional, Harrison, Louise, additional, Jarapa, Rowilson, additional, Wood, Edith, additional, O'Loughlin, Victoria, additional, Cohen, David, additional, Davies, Silvie, additional, Njoku, Kelechi, additional, Mpelembue, Mushiya, additional, Burgess, Laura, additional, Licenik, Radim, additional, Ngwako, Mmua, additional, Nisar, Nabeela, additional, Niranchanan, Rangah, additional, Roganova, Tatjana, additional, Bathula, Rajaram, additional, Devine, Joseph, additional, David, Anette, additional, Oshodi, Anne, additional, Guo, Fenglin, additional, Owoyele, Emmanuelle, additional, Sukdeo, Varthi, additional, Ballantine, Robert, additional, Abbdul-saheb, Mudhar, additional, Chamberlain, Angela, additional, Chandrakumar, Aberami, additional, Poku, Philip, additional, Harkness, Kirsty, additional, Blank, Catrin, additional, Richards, Emma, additional, Ali, Ali, additional, Kibutu, Faith, additional, Balitska, Olesia, additional, Birchall, Kathryn, additional, Bayliss, Pauline, additional, Doyle, Clare, additional, Stocks, Kathy, additional, Majis, Arshad, additional, Howe, Jo, additional, Kamara, Christine, additional, Barron, Luke, additional, Maatouk, Ahmad, additional, Lindert, Ralf, additional, Dakin, Katy, additional, Redgrave, Jessica, additional, Bhaskaran, Biju, additional, Salih, Isam, additional, Kelly, Debs, additional, Szabo, Susan, additional, Tomlin, Dawn, additional, Bearne, Helen, additional, Buxton, Jean, additional, Fitzell, Pauline, additional, Ayres, Georgina, additional, Saulat, Afaq, additional, Horan, Kathleen, additional, Garfield-Smith, Joanne, additional, Bhakri, Harbens, additional, Guyler, Paul, additional, Sinha, Devesh, additional, Loganathan, Thayalini, additional, Siddiqui, Amber, additional, Siddiqui, Anwer, additional, Coward, Lucy, additional, Kunhunny, Swapna, additional, Tysoe, Sharon, additional, Orath Prabakaran, Rajalakshmi, additional, Kelavkar, Shyam, additional, Rashmi, Sindhu, additional, Ngo, David, additional, Ng, Kheng Xiong, additional, Menon, Nisha, additional, Shah, Sweni, additional, Barber, Mark, additional, Esson, Derek, additional, Brodie, Fiona, additional, Anjum, Talat, additional, Wani, Mushtaq, additional, Krishnan, Manju, additional, Quinn, Leanne, additional, Spencer, Jayne, additional, Jones, Terry, additional, Thompson-Jones, Helen, additional, Dacey, Lynne, additional, Chenna, Srikanth, additional, Storton, Sharon, additional, Thomas, Sarah, additional, Beaty, Teresa, additional, Treadwell, Shelley, additional, Davies, Caroline, additional, Tucker, Susan, additional, Connor, Lynda, additional, Slade, Peter, additional, Gainard, Glyn, additional, Muddegowda, Girish, additional, Sanyal, Ranjan, additional, Remegoso, Alda, additional, Abano, Nenette, additional, Causley, Chelsea, additional, Carpio, Racquel, additional, Stevens, Stephanie, additional, Butler, Adrian, additional, Varquez, Resti, additional, Denic, Hayley, additional, Alipio, Francis, additional, Moores, Andrew, additional, Barry, Adrian, additional, Maguire, Holly, additional, Grocott, Jeanette, additional, Finney, Kay, additional, Lyjko, Sue, additional, Roffe, Christine, additional, Hiden, Joanne, additional, Ferdinand, Phillip, additional, Cvoro, Vera, additional, Ullah, Khalil, additional, Chapman, Nicola, additional, Couser, Mandy, additional, Pound, Susan, additional, Mcauley, Sean, additional, Raghunathan, Senthil, additional, Shelton, Faye, additional, Hedstrom, Amanda, additional, Godfrey, Margi, additional, Havard, Diane, additional, Buck, Amanda, additional, Krishnan, Kailash, additional, Gilzeane, Nicola, additional, Roffe, Jack, additional, Clarke, Judith, additional, Whittamore, Katherine, additional, Sheikh, Saima, additional, Keshvara, Rekha, additional, Jordan, Carla, additional, Jackson, Benjamin, additional, Wilkes, Gwendoline, additional, Appleton, Jason, additional, Law, Zhe, additional, Matias, Oliver, additional, Vasileiadis, Evangelos, additional, Mason, Cathy, additional, Parry, Anthea, additional, Landers, Geraldine, additional, Holden, Melinda, additional, Aweid, Basaam, additional, Rashed, Khalid, additional, Balian, Linda, additional, Vickers, Carinna, additional, Keeling, Elizabeth, additional, Board, Sarah, additional, Allison, Joanna, additional, Buckley, Clare, additional, Williams-Yesson, Barbara, additional, Board, Joanne, additional, Pitt-Kerby, Tressy, additional, Tanate, Alfonso, additional, Wood, Diane, additional, Kini, Manohar, additional, Chadha, Dinesh, additional, Walstow, Deborah, additional, Fong, Rosanna, additional, Luder, Robert, additional, Adesina, Tolu, additional, Gallagher, Jill, additional, Bridger, Hayley, additional, Murali, Elodie, additional, Bhargava, Maneesh, additional, van Someren, Chloe, additional, Harrington, Frances, additional, Mate, Abhijit, additional, James, Ali, additional, Courtauld, Gillian, additional, Schofield, Christine, additional, Adie, Katja, additional, Lucas, Linda, additional, Bond, Kirsty, additional, Maund, Bev, additional, Ellis, Sam, additional, Mudd, Paul, additional, James, Martin, additional, Keenan, Samantha, additional, Bowring, Angela, additional, Cageao, Julie, additional, Kingwell, Hayley, additional, Roughan, Caroline, additional, Hemsley, Anthony, additional, Sword, Jane, additional, Strain, David, additional, Miller, Keniesha, additional, Goff, Anita, additional, Gupwell, Karin, additional, Thorpe, Kevin, additional, Emsley, Hedley, additional, Punekar, Shuja, additional, McLoughlin, Alison, additional, Sultan, Sulaiman, additional, Gregory, Bindu, additional, Raj, Sonia, additional, Doyle, Donna, additional, Muir, Keith, additional, Smith, Wilma, additional, Welch, Angela, additional, Moreton, Fiona, additional, Cheripelli, Bharath Kumar, additional, El Tawil, Salwa, additional, Kalladka, Dheeraj, additional, Huang, Xuya, additional, Day, Nicola, additional, Ramachandran, Sankaranarayanan, additional, Crosbie, Caroline, additional, Elliot, Jennifer, additional, Rudd, Tony, additional, Marks, Katherine, additional, Bhalla, Ajay, additional, Birns, Jonathan, additional, Kullane, Sagal, additional, Weir, Nic, additional, Allen, Christopher, additional, Pressly, Vanessa, additional, Crawford, Pam, additional, Battersby-Wood, Emma, additional, Blades, Alex, additional, Egerton, Shuna, additional, Walters, Ashleigh, additional, Evans, Sue, additional, Marigold, James Richard, additional, Smith, Fiona, additional, Howard, Gabriella, additional, Gartrell, Imogen, additional, Smith, Simon, additional, Creeden, Robyn, additional, Cox, Chloe, additional, Boxall, Cherish, additional, Hewitt, Jonathan, additional, Nott, Claire, additional, Sarah, Procter, additional, Whiteman, Jessica, additional, Buckle, Steve, additional, Wallace, Rebecca, additional, Mardania, Rina, additional, Gray, Jane, additional, Triscott, Claire, additional, Nair, Anand, additional, Greig, Jill, additional, Rana, Pratap, additional, Robinson, Matthew, additional, Alam, Mohammad Irfan, additional, Werring, David, additional, Wilson, Duncan, additional, Watchurst, Caroline, additional, Brezitski, Maria, additional, Crook, Luci, additional, Jones, Ifan, additional, Banaras, Azra, additional, Patel, Krishna, additional, Erande, Renuka, additional, Hogan, Caroline, additional, Hostettler, Isabel, additional, Ashton, Amy, additional, Feerick, Shez, additional, Francia, Nina, additional, Oji, Nnebuife, additional, Elliott, Emma, additional, Al-Mayhani, Talal, additional, Dennis, Martin, additional, Sudlow, Cathie, additional, Whiteley, William, additional, Al-Shahi Salman, Rustam, additional, Dutta, Dipankar, additional, 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Lovelock, Caroline, additional, Clarke, Brian, additional, Chopra, Neha, additional, Clarke, Natasha, additional, Patel, Bhavini, additional, Kennedy, Kate, additional, Williams, Rebecca, additional, Blight, Adrian, additional, O'Reilly, Joanna, additional, Orefo, Chukwuka, additional, Dayal, Nilofer, additional, Ghatala, Rita, additional, Adedoyin, Temi, additional, Watson, Fran, additional, Trippier, Sarah, additional, Choy, Lillian, additional, Moynihan, Barry, additional, Khan, Usman, additional, Jones, Val, additional, Jeyaraj, Naomi, additional, Kerin, Lourda, additional, Thavanesan, Kamy, additional, Tiwari, Divya, additional, Cox, Chantel, additional, Ljubez, Anja, additional, Tucker, Laura, additional, Iqbal, Arshi, additional, Bagnall, Caroline, additional, Keltos, Marketa, additional, Roberts, Josh, additional, Jupp, Becky, additional, Ovington, Catherine, additional, Rogers, Emily, additional, David, Owen, additional, Bell, Jo, additional, Longland, Barbara, additional, Hann, Gail, additional, Cooper, Martin, additional, Nasar, Mohammad, additional, Rajapakse, Anoja, additional, Wynter, Inez, additional, Anwar, Ijaz, additional, Skinner, Helen, additional, Nozedar, Tarn, additional, McArdle, Damian, additional, Kumar, Balakrishna, additional, Crawford, Susan, additional, Annamalai, Arunkumar, additional, Ramshaw, Alex, additional, Holmes, Clare, additional, Caine, Sarah, additional, Osborn, Mairead, additional, Dodd, Emily, additional, Murphy, Peter, additional, Devitt, Nicola, additional, Baker, Pauline, additional, Steele, Amy, additional, Guthrie, Lucy Belle, additional, Clarke, Samantha, additional, Hassan, Ahamad, additional, Waugh, Dean, additional, Veraque, Emelda, additional, Makawa, Linetty, additional, Kambafwile, Mary, additional, Randall, Marc, additional, Papavasileiou, Vasileios, additional, Cullen, Claire, additional, Peters, Jenny, additional, Thant, Hlaing, additional, Ingram, Tanya, additional, Zoe, Mellor, additional, Durairaj, 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Fiona, additional, Argandona, Lucia, additional, Cuenoud, Larissa, additional, Erumere, Esther, additional, Amlani, Sageet, additional, Auld, Grace, additional, Salek-Haddadi, Afraim, additional, Schulz, Ursula, additional, Kennedy, James, additional, Ford, Gary, additional, Mathieson, Philip, additional, Reckless, Ian, additional, Teal, Rachel, additional, Lenti, Giulia, additional, Harston, George, additional, O'Brien, Eoin, additional, Mcgee, Joanne, additional, Mitchell, Jennifer, additional, Amis, Elaine, additional, Handley, Dominic, additional, Kelly, Siobhan, additional, Zachariah, George, additional, Francis, Jobbin, additional, Crisp, Sarah, additional, Sesay, Juliana, additional, Finlay, Sarah, additional, Hayhoe, Helen, additional, Hannon, Niamh, additional, Hughes, Tom, additional, Morse, Bethan, additional, De Berker, Henry, additional, Tallantyre, Emma, additional, Osman, Ahmed, additional, White, Susan, additional, Schwarz, Stefan, additional, Jelley, Benjamin, additional, Yadava, Rajendra, additional, Azhar, Khalid, additional, Reddan, Julie, additional, Sangombe, Mirriam, additional, Stafford, Samantha, additional, Fotherby, Ken, additional, Morgan, Debbie, additional, Baig, Farrukh, additional, Jennings-Preece, Karla, additional, Butler, Donna, additional, Ahmad, Nasar, additional, Willberry, Angela, additional, Stevens, Angela, additional, Rai, Baljinder, additional, Siddegowda, Prasad, additional, Howard, Peter, additional, Hyatt, Lisa, additional, Dobson, Tracey, additional, Jarrett, David, additional, Ponnambath, Suheil, additional, Tandy, Jane, additional, Harrington-Davies, Yasmin, additional, Butler, Rebecca, additional, James, Claire, additional, Valentine, Stacey, additional, Suttling, Anne, additional, Langhorne, Peter, additional, Kerr, Gillian, additional, Wright, Fiona, additional, Graham, Ruth, additional, McAlpine, Christine, additional, Iqbal, Mohammad Shahzad, additional, Humphreys, Louise, additional, Pasco, Kath, additional, Balazikova, Olga, additional, Nasim, Ashraf, additional, Peixoto, Cassilda, additional, Gallagher, Louise, additional, Shahmehri, Shahrzad, additional, Ghosh, Sandip, additional, Barrie, Elizabeth, additional, Gilmour, Danielle, additional, Henry, Margo, additional, Webb, Tom, additional, Cowie, Linda, additional, Rudenko, Hannah, additional, McDonald, Shanni, additional, Schumacher, Natasha, additional, Walker, Susannah, additional, Cosier, Tracey, additional, Verrion, Anna, additional, Beranova, Eva, additional, Thomson, Audrey, additional, Venter, Marius, additional, Kar, Arindam, additional, Mashate, Sheila, additional, Harvey, Kirsten, additional, Gardener, Léjeune, additional, Nguyen, Vinh, additional, Halse, Omid, additional, Geraghty, Olivia, additional, Hazel, Beth, additional, Wilding, Peter, additional, Tilley, Victoria, additional, Cassidy, Tim, additional, McClelland, Beverley, additional, Bokhari, Maria, additional, England, Timothy, additional, Maddula, Mohana, additional, Donnelly, Richard, additional, Findlay, Paul, additional, Macaden, Ashish, additional, Shread, Ian, additional, Barr, Charlotte, additional, Mohd Nor, Azlisham, additional, Brown, Claire, additional, Persad, Nicola, additional, Eglinton, Charlotte, additional, Weinling, Marie, additional, Hyams, Benjamin, additional, Shah, Alex, additional, Baker, John, additional, Byrne, Anthony, additional, McGhee, Caroline, additional, Smart, Amanda, additional, Copeland, Claire, additional, Carpenter, Michael, additional, Walker, Marion, additional, Davey, Richard, additional, Needle, Ann, additional, Fathima, Razik, additional, Bateman, Gavin, additional, Datta, Prabal, additional, Stanners, Andrew, additional, Jackson, Linda, additional, Ball, Julie, additional, Davis, Michelle, additional, Atkinson, Natalie, additional, Fawcett, Michelle, additional, Thompson, Teresa, additional, Guy, Helen, additional, Hogg, Valerie, additional, Hays, Carole, additional, Woodward, Stephen, additional, Haque, Mohammad, additional, Hakim, Eluzai, additional, Symonds, Stuart, additional, Maanoosi, Mehran, additional, Herman, Jane, additional, Black, Toby, additional, Miriam, Skelton, additional, Clarke, Caroline, additional, Anthony, Alpha, additional, Tribbeck, Michele, additional, Cronin, Julie, additional, Mead, Denise, additional, Fennelly, Ruth, additional, McIlmoyle, James, additional, Dickinson, Christina, additional, Jeffs, Carol, additional, Anwar, Sajjad, additional, Howard, Joanne, additional, Jones, Kirsty, additional, Dhar, Saikat, additional, Clay, Caroline, additional, Siddiq, Muhammad, additional, Ivatts, Simone, additional, Baird, Yolanda, additional, Sally, Moore, additional, Amey, Isobel, additional, Newton, Sophie, additional, Clayton-Evans, Lisa, additional, Chadbourn, Indra, additional, Rayessa, Rayessa, additional, Naylor, Charde, additional, Rodgers, Alicia, additional, Wilson, Lisa, additional, Wilson, Sarah, additional, Clarkson, Emma, additional, Davies, Ruth, additional, Owings, Paula, additional, Sangster, Graeme, additional, Gott, Valerie, additional, Little, Victoria, additional, Weir, Pauline, additional, Cherian, Suja, additional, Jose, Deepa, additional, Moroney, Helen, additional, Downham, Susan, additional, Dodd, Angela, additional, Vettimootal Johnson, Venetia, additional, Codd, Laura, additional, Robinson, Naomi, additional, Ahmed, Ashraf, additional, Albazzaz, Mo, additional, Johnson, Sharon, additional, Denniss, Carol, additional, Cunningham, Mishell, additional, Zahoor, Tajammal, additional, Webster, Timothy, additional, Leason, Sandra, additional, Haider, Syed, additional, Chatterjee, Kausic, additional, Nallasivan, Arumugam, additional, Perkins, Charlotte, additional, Seagrave, Samantha, additional, Jenkins, Colin, additional, Price, Fiona, additional, Hughes, Claire, additional, Mercer, Lily, additional, Hussain, Malik, additional, Brown, Sarah, additional, Harvey, Miriam, additional, Homan, Jane, additional, Khan, Mohammad, additional, Whiting, Robert, additional, Foote, Leanne, additional, Hunt, Nicholas, additional, Durman, Helen, additional, Brotherton, Lucy, additional, Foot, Jayne, additional, Pawley, Corinne, additional, Foster, Eliza, additional, Whitcher, Alison, additional, Metcalf, Kneale, additional, Jagger, Jenny, additional, McDonald, Susan, additional, Waterfield, Kelly, additional, Sutton, Patrick, additional, Shinh, Naval, additional, Anversha, Ajmal, additional, Ravenhill, Garth, additional, Greenwood, Richard, additional, Saada, Janak, additional, Wiltshire, Alison, additional, Perfitt, Rebekah, additional, Andole, Sreeman, additional, Gadapa, Naveen, additional, Dunne, Karen, additional, Krommyda, Magdalini, additional, Burssens, Evelyne, additional, King, Sam, additional, Plewa, Catherine, additional, Smyth, Nigel, additional, Wilson, Jenny, additional, Giallombardo, Elio, additional, Sykes, Lucy, additional, Kumar, Pradeep, additional, Barker, James, additional, Huggett, Isabel, additional, Dunn, Linda, additional, Culmsee, Charlotte, additional, Thomas, Philip, additional, Myint, Min, additional, Brew, Helen, additional, Majmudar, Nikhil, additional, OConnell, Janice, additional, Bunea, George, additional, Fox, Charlotte, additional, Gulliver, Diane, additional, Smith, Andrew, additional, Mokoena, Betty, additional, Sattar, Naweed, additional, Krishnamurthy, Ramesh, additional, Osborne, Emily, additional, Wilson, David, additional, Wroath, Belinda, additional, Dynan, Kevin, additional, Power, Michael, additional, Thompson, Susan, additional, Adell, Victoria, additional, Orugun, Enoch, additional, Poultney, Una, additional, Glover, Rachel, additional, Crowther, Hannah, additional, Thornthwaite, Sarah, additional, Wiggam, Ivan, additional, Wallace, Aine, additional, Kerr, Enda, additional, Fulton, Ailsa, additional, Hunter, Annemarie, additional, Tauro, Suzanne, additional, Cuddy, Sarah, additional, Mangion, David, additional, Hardwick, Anne, additional, Markova, Skarlet, additional, Lawrence, Tara, additional, Constantin, Carmen, additional, Fletcher, Jo, additional, Thomas, Isobel, additional, Pettitt, Kerry, additional, Sekaran, Lakshmanan, additional, Tate, Margaret, additional, Bharaj, Kiranjit, additional, Simon, Rohan, additional, Justin, Frances, additional, Sethuraman, Sakthivel, additional, Phiri, Duke, additional, Mohammed, Niaz, additional, Chauhan, Meena, additional, Elfandi, Khaled, additional, Khan, Uzma, additional, Eveson, David, additional, Mistri, Amit, additional, Manning, Lisa, additional, Khan, Shagufta, additional, Patel, Champa, additional, Moqsith, Mohammed, additional, Sattar, Saira, additional, Lam, Man Yee, additional, Musarrat, Kashif, additional, Stephens, Claire, additional, Kalathil, Latheef, additional, Miller, Richard, additional, Salehin, Maqsud, additional, Gautam, Nikki, additional, Bailey, Duncan, additional, Amor, Kelly, additional, Meir, Julie, additional, Nicolson, Anne, additional, Imam, Javed, additional, Wood, Lisa, additional, White, Julie, additional, Sajid, Mahmud, additional, Ghaly, George, additional, Ball, Margaret, additional, Gascoyne, Rachel, additional, Proeschel, Harald, additional, Sharpe, Simon, additional, Horton, Sarah, additional, Beaves, Emily, additional, Jones, Stephanie, additional, Yip, Brigitte, additional, Bell, Murdina, additional, MacLiver, Linda, additional, MacInnes, Brian, additional, Sims, Don, additional, Hurley, Jennifer, additional, Willmot, Mark, additional, Sutton, Claire, additional, Littleton, Edward, additional, Maiden, Susan, additional, Jones, Rachael, additional, Cunningham, James, additional, Green, Carole, additional, Bates, Michelle, additional, Shekhar, Raj, additional, Gilham, Ellie, additional, Ahmed, Iman, additional, Crown, Rachel, additional, Fuller, Tracy, additional, Goorah, Neetish, additional, Bell, Angela, additional, Kelly, Christine, additional, Singh, Arun, additional, Walford, Jamie, additional, Tomlinson, Benjamin, additional, Patel, Farzana, additional, Duberley, Stephen, additional, Kane, Ingrid, additional, Rajkumar, Chakravarthi, additional, Gaylard, Jane, additional, Breeds, Joanna, additional, Gainsborough, Nicola, additional, Pitt-Ford, Alexandra, additional, Barbon, Emma, additional, Latter, Laura, additional, Thompson, Philip, additional, Hervey, Simon, additional, Krishnamoorthy, Shrivakumar, additional, Vassallo, Joseph, additional, Walter, Deborah, additional, Cochrane, Helen, additional, Srinivasan, Meena, additional, Campbell, Robert, additional, Donaldson, Denise, additional, Motherwell, Nichola, additional, Hurford, Frances, additional, Mukherjee, Indranil, additional, Kenton, Antony, additional, Nyabadza, Sheila, additional, Martin, Irene, additional, Hunt, Benjamin, additional, Hassan, Hardi, additional, O'Toole, Sarah, additional, Dallol, Bander, additional, Putterill, Janet, additional, Jha, Ratneshwari, additional, Gallifent, Rachel, additional, Kakar, Puneet, additional, Pusalkar, Aparna, additional, Chan, kelly, additional, Dangri, Puneet, additional, Beadle, Hannah, additional, Cook, Angela, additional, Crabtree, Karen, additional, Subramonian, Santhosh, additional, Owusu-Agyei, Peter, additional, Temple, Natalie, additional, Butterworth-Cowin, Nicola, additional, Ragab, Suzanne, additional, Knops, Kerstin, additional, Jinks, Emma, additional, Dickson, Christine, additional, Gleave, Laura, additional, Dube, Judith, additional, Leggett, Jacqui, additional, Garcia, Tatiana, additional, Ispoglou, Sissy, additional, Evans, Rachel, additional, Ankolekar, Sandeep, additional, Hayes, Anne, additional, Ni, Hlaing, additional, Rahman, Bithi, additional, Milligan, Josette, additional, Graham, Carol, additional, Jose, Josin, additional, Keegan, Breffni, additional, Kelly, Jim, additional, Dewar, Richard, additional, White, James, additional, and Thomas, Kelly, additional

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2019
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20. Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

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Dennis, Martin, primary, Mead, Gillian, additional, Forbes, John, additional, Graham, Catriona, additional, Hackett, Maree, additional, Hankey, Graeme J, additional, House, Allan, additional, Lewis, Stephanie, additional, Lundström, Erik, additional, Sandercock, Peter, additional, Innes, Karen, additional, Williams, Carol, additional, Drever, Jonathan, additional, Mcgrath, Aileen, additional, Deary, Ann, additional, Fraser, Ruth, additional, Anderson, Rosemary, additional, Walker, Pauli, additional, Perry, David, additional, Mcgill, Connor, additional, Buchanan, David, additional, Chun, Yvonne, additional, Dinsmore, Lynn, additional, Maschauer, Emma, additional, Barugh, Amanda, additional, Mikhail, Shadia, additional, Blair, Gordon, additional, Hoeritzauer, Ingrid, additional, Scott, Maggie, additional, Fraser, Greig, additional, Lawrence, Katherine, additional, Shaw, Alison, additional, Williamson, Judith, additional, Burgess, David, additional, Macleod, Malcolm, additional, Morales, Dan, additional, Sullivan, Frank, additional, Brady, Marian, additional, French, Ray, additional, Van Wijck, Frederike, additional, Watkins, Caroline, additional, Proudfoot, Fiona, additional, Skwarski, Joanna, additional, Mcgowan, Diane, additional, Murphy, Rachael, additional, Burgess, Seona, additional, Rutherford, William, additional, Mccormick, Katrina, additional, Buchan, Ruaridh, additional, Macraild, Allan, additional, Paulton, Ruth, additional, Fazal, Adnan, additional, Taylor, Pat, additional, Parakramawansha, Ruwan, additional, Hunter, Neil, additional, Perry, Jack, additional, Bamford, John, additional, Waugh, Dean, additional, Veraque, Emelda, additional, Bedford, Caroline, additional, Kambafwile, Mary, additional, Idrovo, Luis, additional, Makawa, Linetty, additional, Smalley, Paula, additional, Randall, Marc, additional, Thirugnana-Chandran, Tharani, additional, Hassan, Ahamad, additional, Vowden, Richard, additional, Jackson, Joanne, additional, Bhalla, Ajay, additional, Rudd, Anthony, additional, Tam, Chi Kai, additional, Birns, Jonathan, additional, Gibbs, Charlotte, additional, Lee Carbon, Leonie, additional, Cattermole, Elizabeth, additional, Marks, Katherine, additional, Cape, Angela, additional, Hurley, Lisa, additional, Kullane, Sagal, additional, Smyth, Nigel, additional, Eglinton, Charlotte, additional, Wilson, Jennifer, additional, Giallombardo, Elio, additional, Frith, Angela, additional, Reidy, Paul, additional, Pitt, Matthew, additional, Sykes, Lucy, additional, Dellafera, Deborah, additional, Croome, Victoria, additional, Kerwood, Lauriane, additional, Hancevic, Mirea, additional, Narh, Christina, additional, Merritt, Carley, additional, Duffy, John, additional, Cooke, Duncan, additional, Willson, Juliet, additional, Ali, Ali, additional, Naqvi, Aaizza, additional, Kamara, Christine, additional, Bowler, Helen, additional, Bell, Simon, additional, Jackson, Tracy, additional, Harkness, Kirsty, additional, Stocks, Kathy, additional, Duty, Suzanna, additional, Doyle, Clare, additional, Dunn, Geoffrey, additional, Endean, Keith, additional, Claydon, Fiona, additional, Richards, Emma, additional, Howe, Jo, additional, Lindert, Ralf, additional, Majid, Arshad, additional, Dakin, Katy, additional, Maatouk, Ahmad, additional, Barron, Luke, additional, Meegada, Madana, additional, Rana, Pratap, additional, Nair, Anand, additional, Brighouse-Johnson, Christine, additional, Greig, Jill, additional, Kyu, Myint, additional, Prasad, Sanjeev, additional, Robinson, Matthew, additional, Alam, Irfan, additional, Mclean, Belinda, additional, Greenhalgh, Lindsay, additional, Ahmed, Zenab, additional, Roffe, Christine, additional, Brammer, Susan, additional, Beardmore, Carole, additional, Finney, Kay, additional, Barry, Adrian, additional, Hollinshead, Paul, additional, Grocott, Jeanette, additional, Maguire, Holly, additional, Natarajan, Indira, additional, Chembala, Jayan, additional, Sanyal, Ranjan, additional, Lijko, Sue, additional, Abano, Nenette, additional, Remegoso, Alda, additional, Ferdinand, Phillip, additional, Stevens, Stephanie, additional, Varquez, Resti, additional, Causley, Chelsea, additional, Butler, Adrian, additional, Whitmore, Philip, additional, Stephen, Caroline, additional, Carpio, Racquel, additional, Hiden, Joanne, additional, Muddegowda, Girish, additional, Denic, Hayley, additional, Sword, Jane, additional, Curwen, Ross, additional, James, Martin, additional, Mudd, Paul, additional, Hall, Fiona, additional, Cageao, Julie, additional, Keenan, Samantha, additional, Roughan, Caroline, additional, Kingwell, Hayley, additional, Hemsley, Anthony, additional, Lohan, Christoph, additional, Davenport, Sue, additional, Bowring, Angela, additional, Chapter, Tamika, additional, Hough, Max, additional, Strain, David, additional, Gupwell, Karin, additional, Miller, Keniesha, additional, Goff, Anita, additional, Cusack, Ellie, additional, Todd, Shirley, additional, Partridge, Rebecca, additional, Jennings, Georgiana, additional, Thorpe, Kevin, additional, Stephenson, Jacquelyn, additional, Littlewood, Kelly, additional, Barber, Mark, additional, Brodie, Fiona, additional, Marshall, Steven, additional, Esson, Derek, additional, Coburn, Irene, additional, Mcinnes, Caroline, additional, Ross, Fiona, additional, Bowie, Emma, additional, Barcroft, Heather, additional, Withers, Victoria, additional, Miller, Laura, additional, Willcoxson, Paul, additional, Donninson, Michelle, additional, Evans, Richard, additional, Daniel, Di, additional, Coyle, John, additional, Keeling, Michael, additional, Wanklyn, Peter, additional, Elliott, Mark, additional, Wightman, John, additional, Iveson, Elizabeth, additional, Dyer, Natasha, additional, Porteous, Anne-Marie, additional, Haritakis, Monica, additional, Ward, Mandy, additional, Doughty, Lucy, additional, Carr, Lisa, additional, O Neill, Mark, additional, Anazodo, Cosmas, additional, Wood, Paul, additional, Cottrell, Poppy, additional, Donne, Cheryl, additional, Rodriguez, Romina, additional, Mir, Ruhail, additional, Westmoreland, Jax, additional, Bell, Judith, additional, Emms, Christopher, additional, Wright, Lorraine, additional, Clark Brown, Pearl, additional, Bamford, Elizabeth, additional, Stanners, Andrew, additional, Carpenter, Mike, additional, Datta, Prabal, additional, Davey, Richard, additional, Needle, Ann, additional, Eastwood, Marjorie Jane, additional, Razik, Fathima Zeena, additional, Ghouri, Imran, additional, Bateman, Gavin, additional, Archer, Judy, additional, Balasubramanian, Venkatesh, additional, Bowers, Richard, additional, Ball, Julie, additional, Benton, Louise, additional, Jackson, Linda, additional, Ellam, Julie, additional, Norton, Kate, additional, Guyler, Paul, additional, Dowling, Terry, additional, Tysoe, Sharon, additional, Harman, Paula, additional, Kundu, Ashish, additional, Omodunbi, Ololade, additional, Loganathan, Thayalini, additional, Chandler, Stuart, additional, Noor, Shanas, additional, Siddiqui, Anwer, additional, Siddiqui, Amber, additional, Kunhunny, Swapna, additional, Sinha, Devesh, additional, Sheppard, Martin, additional, Rashmi, Sindhu, additional, France, Elena, additional, Orath Prabakaran, Rajalakshmi, additional, Wilson, Laura, additional, Ropun, Amiirah, additional, Kelavkar, Shyam, additional, Ng, Kheng Xiong, additional, Kamuriwo, Lucy, additional, Shah, Sweni, additional, Mangion, David, additional, Constantin, Camen, additional, De Michele Hock, Luigi, additional, Hardwick, Anne, additional, Borley, Jayne, additional, Markova, Skarlet, additional, Netherton, Kimberley, additional, Lawrence, Tara, additional, Fletcher, Jo, additional, Spencer, Rebecca, additional, Palmer, Helen, additional, Cullen, Claire, additional, Hamill, Dolores, additional, Durairaj, Ramesh, additional, Mellor, Zoe, additional, Fluskey, Tanya, additional, Wood, Diane, additional, Keeling, Alison, additional, Hankin, Victoria, additional, Peters, Jennifer, additional, Shackcloth, Daniela, additional, Hlaing, Thant, additional, Tangney, Rebecca, additional, Ewing, Jordan, additional, Harrison, Melanie, additional, Stevenson, Sarah, additional, Sutton, Victoria, additional, Soliman, Mohamed, additional, Hindle, Julia, additional, Watson, Elizabeth, additional, Hewitt, Claire, additional, Butler, Susie, additional, Wahishi, Ibrahim, additional, Arif, Sarwat, additional, Fields, Amy, additional, Sharma, Jagdish, additional, Brown, Rose, additional, Taylor, Caroline, additional, Bell, Sarah, additional, Leach, Simon, additional, Patterson, Chris, additional, Khan, Sophia, additional, Wilson, Helen, additional, Price, Joanne, additional, Ramadan, Hawraman, additional, Maguire, Stuart, additional, Bellfield, Ruth, additional, Hooley, Michaela, additional, Hamid, Umair, additional, Gaba, Waqar, additional, Ghulam, Robina, additional, Masters, Leslie, additional, Quinn, Outi, additional, Sekaran, Lakshmanan, additional, Tate, Margaret, additional, Mohammed, Niaz, additional, Bharaj, Kiranjit, additional, Justin, Frances, additional, Pattni, Rajan, additional, Alwis, Lanka, additional, Sethuraman, Sakthivel, additional, Robinson, Rianne, additional, Eldridge, Lianne, additional, Mintias, Susan, additional, Chauhan, Meena, additional, Tam, Chi-Kai, additional, Palmones, Jeremias, additional, Holmes, Clare, additional, Guthrie, Lucy Belle, additional, Osborn, Mairead, additional, Ball, Lindsay, additional, Caine, Sarah, additional, Steele, Amy, additional, Murphy, Peter, additional, Devitt, Nikki, additional, Leonard, Jayne, additional, Patel, Ronak, additional, Penwarden, Ian, additional, Dodd, Emily, additional, Holloway, Amy, additional, Baker, Pauline, additional, Clarke, Samantha, additional, Williams, Sandra, additional, Dow, Lindsey, additional, Wynn-Williams, Roland, additional, Kennedy, James, additional, Teal, Rachel, additional, Schulz, Ursula, additional, Ford, Gary, additional, Mathieson, Philip, additional, Reckless, Ian, additional, Deveciana, Ana, additional, Mccann, Paige, additional, Cluckie, Gillian, additional, Howell, Geoffrey, additional, Ayer, Jonathan, additional, Moynihan, Barry, additional, Ghatala, Rita, additional, Clarke, Brian, additional, Cloud, Geoffrey, additional, Patel, Bhavini, additional, Khan, Usman, additional, Al-Samarrai, Nia, additional, Trippier, Sarah, additional, Chopra, Neha, additional, Adedoyin, Temi, additional, Watson, Fran, additional, Jones, Val, additional, Zhang, Liqun, additional, Choy, Lillian, additional, Williams, Rebecca, additional, Clarke, Natasha, additional, Blight, Adrian, additional, Kennedy, Kate, additional, Dainty, Alice, additional, Selvarajah, Johann, additional, Kalladka, Dheeraj, additional, Cheripelli, Bharath, additional, Smith, Wilma, additional, Moreton, Fiona, additional, Welch, Angela, additional, Huang, Xuya, additional, Douglas, Elizabeth, additional, Lush, Audrey, additional, Day, Nicola, additional, El Tawil, Salwa, additional, Montgomery, Karen, additional, Hamilton, Helen, additional, Ritchie, Doreen, additional, Ramachandra, Sankaranarayanan, additional, Mcleish, Kirsty, additional, Thavanesan, Kamy, additional, Loganathan, Sathyabama, additional, Roberts, Josh, additional, Cox, Chantel, additional, Orr, Sarah, additional, Hogan, Alison, additional, Tiwari, Divya, additional, Hann, Gail, additional, Longland, Barbara, additional, David, Owen, additional, Bell, Jo, additional, Ovington, Catherine, additional, Rogers, Emily, additional, Bower, Rachel, additional, Keltos, Marketa, additional, Cohen, David, additional, Devine, Joseph, additional, Alwis, Lankantha, additional, Southworth, Lucy, additional, Burgess, Laura, additional, Lang, Matilda, additional, Badiani, Bhavna, additional, Guo, Fenglin, additional, Oshodi, Anne, additional, Owoyele, Emmanuelle, additional, Epie, Norah, additional, David, Anette, additional, Mpelembue, Mushiya, additional, Bathula, Rajaram, additional, Abdul-Saheb, Mudhar, additional, Chamberlain, Angela, additional, Sudkeo, Varthi, additional, Rashed, Khalid, additional, Williams-Yesson, Barbara, additional, Board, Joanne, additional, De Bruijn, Sarah, additional, Buckley, Clare, additional, Board, Sarah, additional, Allison, Joanna, additional, Keeling, Elizabeth, additional, Duckett, Tracey, additional, Donaldson, Dave, additional, Vickers, Carinna, additional, Barron, Claire, additional, Balian, Linda, additional, Wilson, Jodhi, additional, Edwards, Adam, additional, England, Timothy, additional, Hedstrom, Amanda, additional, Bedford, Elizabeth, additional, Harper, Margaret, additional, Melikyan, Elina, additional, Abbott, Wendy, additional, Subramanian, Kashmira, additional, Goldsworthy, Marie, additional, Srinivasan, Meena, additional, Yeomans, Angela, additional, Donaldson, Denise, additional, Hurford, Frances, additional, Chapman, Riquella, additional, Shahzad, Sana, additional, Motherwell, Nicki, additional, Tonks, Louise, additional, Young, Rachel, additional, Ghani, Usman, additional, Mukherjee, Indranil, additional, Dutta, Dipankar, additional, Obaid, Mudhar, additional, Brown, Pauline, additional, Davis, Fiona, additional, Ward, Deborah, additional, Turfrey, Jennifer, additional, Cartwright, Bethan, additional, Topia, Bilal, additional, Spurway, Judith, additional, Collins, Kayleigh, additional, Bakawala, Rehana, additional, Hughes, Chloe, additional, Oconnell, Susan, additional, Hill, Linda, additional, Chatterjee, Kausik, additional, Webster, Tim, additional, Haider, Syed, additional, Rushworth, Pamela, additional, Macleod, Fiona, additional, Nallasivan, Arumugam, additional, Perkins, Charlotte, additional, Burns, Edel, additional, Leason, Sandra, additional, Carter, Tom, additional, Seagrave, Samantha, additional, Sami, Eman, additional, Armstrong, Lisa, additional, Naqvi, Syed Naseem, additional, Hassan, Muhammad, additional, Parkinson, Sharron, additional, Mawer, Samantha, additional, Darnbrook, Gillian, additional, Booth, Carl, additional, Hairsine, Brigid, additional, Smith, Matthew, additional, Williamson, Sue, additional, Farquhar, Fiona, additional, Esisi, Bernard, additional, Cassidy, Tim, additional, Mankin, Gavin, additional, Mcclelland, Beverley, additional, Bokhari, Maria, additional, Sproates, David, additional, Epstein, Elliot, additional, Hurdowar, Steve, additional, Blackburn, Ruth, additional, Sukhdeep, Nazran, additional, Razak, Saika, additional, Osman, Khalid, additional, Hashmi, Amina, additional, Upton, Natasha, additional, Harrington, Frances, additional, Courtauld, Gillian, additional, Schofield, Christine, additional, Lucas, Linda, additional, Adie, Katja, additional, Bond, Kirsty, additional, Mate, Abhijit, additional, Skewes, Jo, additional, James, Ali, additional, Brodie, Carolyn, additional, Johnson, Matthew, additional, Allsop, Linda, additional, Driver, Emma, additional, Harris, Karina, additional, Drake, Mark, additional, Ellis, Sam, additional, Maund, Bev, additional, Thomas, Emma, additional, Moore, Kimberley, additional, Burn, Matthew, additional, Hamilton, Adam, additional, Mahalingam, Shageetha, additional, Misra, Amulya, additional, Reid, Farrah, additional, Benford, Adrienne, additional, Hilton, Derek, additional, Hazell, Lorraine, additional, Ofori, Keziah, additional, Thomas, Anne Louise, additional, Mathew, Moncy, additional, Dayal, Sonia, additional, Burn, Iona, additional, Fotherby, Kenneth, additional, Jennings-Preece, Karla, additional, Willberry, Angela, additional, Morgan, Debbie, additional, Butler, Donna, additional, Sahota, Gurminder, additional, Kauldhar, Kelly, additional, Ahmad, Nasar, additional, Stevens, Angela, additional, Das, Saugata, additional, Bruce, David, additional, Pai, Yogish, additional, Nyo, Khin, additional, Stephenson, Lynsey, additional, Nendick, Richard, additional, Rogers, Gill, additional, Dhakal, Mahesh, additional, Dima, Sofia, additional, Brown, Ellen, additional, Clayton, Susan, additional, Gamble, Penny, additional, Naeem, Muhammad, additional, Hayman, Rachel, additional, Burnip, Rachel, additional, Earnshaw, Philip, additional, Hargroves, David, additional, Ransom, Barbara, additional, Rudenko, Hannah, additional, Balogun, Ibrahim, additional, Griffiths, Kirsty, additional, Mears, Kim, additional, Webb, Tom, additional, Cowie, Linda, additional, Hammond, Tessa, additional, Thomson, Audrey, additional, Ceccarelli, Daniela, additional, Chattha, Navraj, additional, Beranova, Eva, additional, Verrion, Anna, additional, Gillian, Andrew, additional, Schumacher, Natasha, additional, Bahk, Anna, additional, Walker, Susannah, additional, Cvoro, Vera, additional, Chapman, Nicola, additional, Pound, Susan, additional, Cain, Rebecca, additional, Mcauley, Sean, additional, Couser, Mandy, additional, Simpson, Maria, additional, Tachtatzis, Athan, additional, Ullah, Khalil, additional, Sims, Don, additional, Jones, Rachael, additional, Smith, Jonathan, additional, Tongue, Rebecca, additional, Willmot, Mark, additional, Sutton, Claire, additional, Littleton, Edward, additional, Khaira, Jattinder, additional, Maiden, Susan, additional, Cunningham, James, additional, Green, Carole, additional, Chin, Yin-May, additional, Bates, Michelle, additional, Ahlquist, Katherine, additional, Kane, Ingrid, additional, Breeds, Joanna, additional, Sargent, Tenesa, additional, Latter, Laura, additional, Pitt Ford, Alexandra, additional, Gainsborough, Nicola, additional, Levett, Tom, additional, Thompson, Philip, additional, Barbon, Emma, additional, Dunne, Angela, additional, Hervey, Simon, additional, Ragab, Suzanne, additional, Sandell, Tracy, additional, Dickson, Christine, additional, Dube, Judith, additional, Power, Sharon, additional, Evans, Nick, additional, Wadams, Beverley, additional, Elitova, Savina, additional, Aubrey, Beth, additional, Garcia, Tatiana, additional, Mcilmoyle, James, additional, Jeffs, Carol, additional, Dickinson, Christina, additional, Ahmed, Anis, additional, Kumar, Sanjeev, additional, Frudd, Julie, additional, Armer, Charlotte, additional, Potter, Andrew, additional, Donaldson, Stacey, additional, Howard, Joanne, additional, Jones, Kirsty, additional, Dhar, Saikat, additional, Collas, David, additional, Sundayi, Saul, additional, Denham, Lynn, additional, Oza, Deepali, additional, Walker, Elaine, additional, Bhandari, Mohit, additional, Ispoglou, Sissy, additional, Evans, Rachel, additional, Sharobeem, Kamel, additional, Walton, Elaine, additional, Shanu, Steven, additional, Hayes, Anne, additional, Howard-Brown, Jennifer, additional, Billingham, Steven, additional, Weir, Nic, additional, Pressly, Vanessa, additional, Wood, Emma, additional, Howard, Gabriella, additional, Burton, Holly, additional, Crawford, Pam, additional, Egerton, Shuna, additional, Evans, Sue, additional, Hakkak, Jasmine, additional, Andrews, Janet, additional, Lampard, Rebecca, additional, Allen, Christopher, additional, Walters, Ashleigh, additional, Said, Rasha, additional, Marigold, James Richard, additional, Tsang, Sau-Mon, additional, Creeden, Robyn, additional, Cox, Chloe, additional, Smith, Simon, additional, Gartrell, Imogen, additional, Smith, Fiona, additional, Jenkins, Colin, additional, Pryor, Joanna, additional, Hedges, Andrew, additional, Price, Fiona, additional, Moseley, Linda, additional, Mercer, Lily, additional, Hughes, Claire, additional, Azim, Abul, additional, White, Julie, additional, Krasinska-Chavez, Milena, additional, Chaplin, Shaun, additional, Curtis, James, additional, Singh, Deepwant, additional, Imam, Javed, additional, Nicolson, Anne, additional, Alam, Sajid, additional, Whitworth, Simon, additional, Wood, Lisa, additional, Warburton, Elizabeth, additional, Kelly, Siobhan, additional, Mcgee, Joanne, additional, Markus, Hugh, additional, Chandrasena, Denish, additional, Hayden, Derek, additional, Sesay, Juliana, additional, Hayhoe, Helen, additional, Bolton, Mark, additional, Macdonald, Jane, additional, Mitchell, Jenny, additional, Farron, Charlotte, additional, Amis, Elaine, additional, Day, Diana, additional, Culbert, Ainsley, additional, Espanol, Ailene, additional, Hannon, Niamh, additional, Handley, Dominic, additional, Finlay, Sarah, additional, Crisp, Sarah, additional, Whitehead, Lynne, additional, Francis, Jobbin, additional, Oconnell, Janice, additional, Osborne, Emily, additional, Beard, Rod, additional, Krishnamurthy, Ramesh, additional, Mokoena, Langanani, additional, Sattar, Naweed, additional, Myint, Min, additional, Edwards, Michelle, additional, Smith, Andrew, additional, Corrigan, Paul, additional, Byrne, Anthony, additional, Blackburn, Joanne, additional, Mcghee, Caroline, additional, Smart, Amanda, additional, Donaldson, Fiona, additional, Copeland, Claire, additional, Wilson, Jill, additional, Scott, Rhona, additional, Fitzsimmons, Paul, additional, Lopez, Paula, additional, Wilkinson, Mark, additional, Manoj, Aravindakshan, additional, Cox, Penelope, additional, Trainor, Leona, additional, Fletcher, Glyn, additional, Denny, Lisa, additional, Kavanagh, Karen, additional, Allsop, Hannah, additional, Emsley, Hedley, additional, Sultan, Sulaiman, additional, Mcloughlin, Alison, additional, Walmsley, Benjamin, additional, Hough, Louise, additional, Ahmed, Shakeel, additional, Doyle, Donna, additional, Gregary, Bindu, additional, Raj, Sonia, additional, Nagaratnam, Kirubananthan, additional, Mannava, Neelima, additional, Haque, Nyla, additional, Shields, Norma, additional, Preston, Kate, additional, Mason, Geraldine, additional, Short, Kirsty, additional, Lumsdale, Gemma, additional, Uitenbosch, Giulia, additional, Sukys, Ugnius, additional, Valentine, Stacey, additional, Jarrett, David, additional, Dodsworth, Kerry, additional, Wands, Mary, additional, Khan, Nisa, additional, Tandy, Jane, additional, Watkinson, Catrin, additional, Golding, Wendy, additional, Butler, Rebecca, additional, Williams, Max, additional, Davies, Yasmin, additional, Yip, Keith, additional, James, Claire, additional, Suttling, Anne, additional, Maney, Aditya, additional, Gamble, Giles Edward, additional, Hague, Adam, additional, Charles, Bethan, additional, Blane, Sujata, additional, Duran, Beatriz, additional, Lambert, Caroline, additional, Stagg, Katherine, additional, Whiting, Robert, additional, Homan, Jane E, additional, Brown, Sarah, additional, Hussain, Malik, additional, Harvey, Miriam, additional, Graham, Libby, additional, Foote, Leanne, additional, Lane, Catherine, additional, Kemp, Liz (Joan), additional, Rowe, Joy, additional, Durman, Helen, additional, Foot, Jayne, additional, Brotherton, Lucy, additional, Hunt, Nicholas, additional, Pawley, Corinne, additional, Whitcher, Alison, additional, Sutton, Patrick, additional, Mcdonald, Susan, additional, Pak, Denys, additional, Wiltshire, Alison, additional, Jagger, Jennifer, additional, Metcalf, Anthony K, additional, Healey, Gail Louise, additional, Balami, Joyce, additional, Self, Clare Marie, additional, Crofts, Melissa, additional, Chakrabarti, Annie, additional, Hmu, Chit, additional, Ravenhill, Garth, additional, Grimmer, Charmaine, additional, Soe, Thandar, additional, Keshet-Price, Jocelyn, additional, Langley, Margaret, additional, Potter, Ian, additional, Tam, Pui-Lin, additional, Macleod, Mary Joan, additional, Cooper, Patricia, additional, Christie, Michael, additional, Irvine, Janice, additional, Annison, Faye, additional, Christie, David, additional, Meneses, Celia, additional, Johnson, Amber, additional, Joyson, Anu, additional, Nelson, Sandra, additional, Taylor, Vicky, additional, Reid, John, additional, Clarke, Rebecca, additional, Furnace, Jacqueline, additional, Gow, Heather, additional, Abousleiman, Youssif, additional, Beadling, Tania, additional, Collins, Sally, additional, Jones, Stuart, additional, Purcell, Jessica, additional, Bloom, Samantha, additional, Goshawk, Shelly, additional, Landicho, Marcial, additional, Sangaralingham, Sivatharshini, additional, Begum, Yasmin, additional, Mutton, Sherree, additional, Munuswamy Vaiyapuri, Elangovan, additional, Allen, Jane, additional, Lowe, Jemma, additional, Hughes, Martin, additional, Wiggam, Ivan, additional, Cuddy, Sarah, additional, Tauro, Suzanne, additional, Wells, Brian, additional, Mohd Nor, Azlisham, additional, Persad, Nicola, additional, Kalita, Maggie, additional, Weatherby, Stuart, additional, Brown, Claire, additional, Pace, Adrian, additional, Lashley, Daniel, additional, Marner, Mike, additional, Weinling, Marie, additional, Wilmshurst, Natasha, additional, Waugh, Darren, additional, Mucha, Anna, additional, Shah, Alex, additional, Baker, John, additional, Westcott, Jacqueline, additional, Cowan, Richard, additional, Vasileiadis, Evangelos, additional, Mumani, Samira, additional, Parry, Anthea, additional, Mason, Cathy, additional, Holden, Melinda, additional, Petrides, Katerina, additional, Nishiyama, Tomoko, additional, Mehta, Hina, additional, Krishnan, Manju, additional, Lynne, Dacey, additional, Thomas, Lisa, additional, Lynda, Connor, additional, Hughes, Catherine, additional, Clements, Clare, additional, Williams, Rhys, additional, Anjum, Tal, additional, Sharon, Storton, additional, Tucker, Susan, additional, Jones, Paul, additional, Colwill, Deanne, additional, Thompson Jones, Helen, additional, Chadha, Dinesh, additional, Fairweather, Mark, additional, Walstow, Deborah, additional, Fong, Rosanna, additional, Johnston, Stuart, additional, Almadenboyle, Christine, additional, Ross, Sarah, additional, Carson, Shona, additional, Nair, Priya, additional, Tenbruck, Emily, additional, Stirling, Mairi, additional, Pusalkar, Aparna, additional, Beadle, Hannah, additional, Chan, Kelly, additional, Dangri, Puneet, additional, Asokanathan, Asaipillai, additional, Rana, Anita, additional, Gohil, Sunita, additional, Massyn, Mark, additional, Aruldoss, Prabhu, additional, Cook, Angela, additional, Crabtree, Karen, additional, Dabbagh, Sura, additional, Black, Toby, additional, Clarke, Caroline, additional, Mead, Denise, additional, Fennelly, Ruth, additional, Anthony, Alpha, additional, Nardone, Linda, additional, Dimartino, Victoria, additional, Tribbeck, Michele, additional, Broughton, David, additional, Tryambake, Dinesh, additional, Dixon, Lynn, additional, Skotnicka, Agnieszka, additional, Thompson, Jane, additional, Whitehouse, Sarah, additional, Sigsworth, Andrew, additional, Wong, Jason, additional, Annamalai, Arunkumar, additional, Pagan, Julie, additional, Affley, Brendan, additional, Sunderland, Caroline, additional, Goldenberg, Lynda, additional, Khan, Atif, additional, Wilkinson, Peter, additional, Nari, Raad, additional, Abbott, Lucy, additional, Young, Emma, additional, Shakhon, Amritpal, additional, Lock, Sally, additional, Stewart, Jack, additional, Pereira, Rita, additional, Dsouza, Margaret, additional, Dunn, Sally, additional, Mckenna, Anne-Marie, additional, Cron, Nina, additional, Kidd, Michelle, additional, Hull, Grace, additional, Bunworth, Kerry, additional, Drummond, Graham, additional, Mahawish, Karim, additional, Hayes, Nicola, additional, Connell, Lynne, additional, Simpson, Jennifer, additional, Penney, Helen, additional, Punekar, Shuja, additional, Nevinson, Joanne, additional, Wareing, William, additional, Ward, Jacqueline, additional, Greenwood, Richard, additional, Austin, Duncan, additional, Banaras, Azra, additional, Hogan, Carolin, additional, Corbett, Thomas, additional, Oji, Nnebuife, additional, Elliott, Emma, additional, Brezitski, Maria, additional, Passeron, Nathalie, additional, Howaniec, Laura, additional, Watchurst, Caroline, additional, Patel, Krishna, additional, Erande, Renuka, additional, Shah, Rahi, additional, Sengupta, Nabarun, additional, Metiu, Maria, additional, Gonzalez, Celia, additional, Funnell, Sarah, additional, Margalef, Jordi, additional, Peters, Gillian, additional, Chadbourn, Indra, additional, Sivakumar, Ramachandran, additional, Saksena, Rajesh, additional, Ketley-O'donel, Jane, additional, Needle, Richard, additional, Chinery, Elaine, additional, Wright, Alison, additional, Cook, Sue, additional, Ngeh, Joseph, additional, Proeschel, Harald, additional, Cook, Paige, additional, Ashcroft, Pauline, additional, Sharpe, Simon, additional, Jones, Stephanie, additional, Jenkinson, Damian, additional, Kelly, Deborah, additional, Bray, Holly, additional, Gunathilagan, Gunaratnam, additional, Jones, Sally, additional, Tilbey, Sorrell, additional, Abubakar, Saidu, additional, Vassallo, Joseph, additional, Leonard, Dee, additional, Orrell, Lucy, additional, Hasan, Aziz, additional, Khan, Asif, additional, Qamar, Sulmaaz, additional, Graham, Susan, additional, Hewitt, Emma, additional, Awolesi, Jennifer, additional, Haque, Muhammad, additional, Kent, Alissa, additional, Bradshaw, Elizabeth, additional, Cooper, Martin, additional, Wynter, Inez, additional, Rajapakse, Anoja, additional, Janbieh, Joumana, additional, Nasar, Abu M, additional, Wade, Lynne, additional, Otter, Linda, additional, Haigh, Steve, additional, Burgoyne, Jamie-Rae, additional, Boulton, Rebecca, additional, Boulton, Andrew, additional, Rayessa, Rayessa, additional, Clarkson, Emma, additional, Rhian, Horne, additional, Fleming, Amy, additional, Mitchelson, Kim, additional, Lowthorpe, Vicki, additional, Abdul-Hamid, Ahmed, additional, Jones, Phil, additional, Duggan, Claire, additional, Hynes, Abigail, additional, Nurse, Emma, additional, Raza, Syed Abid, additional, Jones, Sarah, additional, Pallikona, Udaya, additional, Edwards, Bleddyn, additional, Morgan, Geraint, additional, Dennett, Kirsty, additional, Tench, Helen, additional, Loosley, Ronda, additional, Trugeon-Smith, Toby, additional, Jones, Rhian, additional, Williams, Richard, additional, Robson, Donna, additional, Mavinamane, Sunanda, additional, Meenakshisundaram, Sanjeevi, additional, Ranga, Lalitha, additional, Dealing, Sharon, additional, Hill, Andrew, additional, Hargreaves, Margaret, additional, Smith, Tom, additional, Bate, Julie, additional, Harrison, Linda, additional, Kirthivasan, Ramanathan, additional, Cannon, Emma, additional, Topliffe, Joanne, additional, Keskeys, Rebecca, additional, Williams, Sarah, additional, Mcneela, Fiona, additional, Cairns, Frances, additional, James, Thomas, additional, Lyle, Amanda, additional, Shah, Sheela, additional, Zachariah, George, additional, Fergey, Lauren, additional, Smolen, Susan, additional, Cooper, Lucy, additional, Bohannan, Elizabeth, additional, Omer, Siddiq, additional, Amlani, Sageet, additional, Hunter, Nadia, additional, Hawkes-Blackburn, Melissa, additional, Gulli, Giosue, additional, Peacocke, Alice, additional, Amero, Justine, additional, Burova, Maria, additional, Speirs, Ottilia, additional, Levy, Steph, additional, Francis, Lynda, additional, Holland, Susan, additional, Brotheridge, Sean, additional, Lyon, Helen, additional, Hare, Christine, additional, Jackson, Samantha, additional, Stephenson, Lorraine, additional, Al Hussayni, Samer, additional, Featherstone, James, additional, Bwalya, Agness, additional, Singh, Arun, additional, Goorah, M N, additional, Walford, Jamie, additional, Bell, Angela, additional, Kelly, Christine, additional, Rusk, Darren, additional, Sutton, Deborah, additional, Patel, Farzana, additional, Duberley, Stephen, additional, Hayes, Kathryn, additional, Hunt, Lorraine, additional, El Nour, Ahmed, additional, Honour, Sacha, additional, Box, Chloe, additional, Dyer, Simon, additional, Brown, Lynne, additional, Elliott, Kerry, additional, Temlett, Emma, additional, Paterson, John, additional, Furness, Rosie, additional, Young, Shelli, additional, Orugun, Enoch, additional, Brewer, Chris, additional, Thornthwaite, Sarah, additional, Crowther, Hannah, additional, Glover, Rachel, additional, Sein, Moe, additional, Haque, Kashif, additional, Gibson, Elspeth, additional, Wong, Sam, additional, Rotchell, Karen, additional, Burton, Karen, additional, Brookes, Lisa, additional, Bailey, Linda, additional, Lindley, Chris, additional, Murray, Abbi, additional, Waltho, Karen, additional, Holland, Maureen, additional, Kumar, Pradeep, additional, Harlekar, Purnima, additional, Booth, Laura, additional, Culmsee, Charlotte, additional, Drew, Jade, additional, Khan, Mohammad, additional, Mackenzie, Nicola, additional, Thomas, Carmel, additional, Ritchie, Jane, additional, Barker, James, additional, Haley, Michael, additional, Cotterill, Donna, additional, Lane, Lynne, additional, Little, Christine, additional, Simmons, Dawn, additional, Saunders, Glenn, additional, Dymond, Harvey, additional, Kidd, Sarah, additional, Warinton, Rachel, additional, Neves-Silva, Yara, additional, Nevajda, Branimir, additional, Villaruel, Michael, additional, Umasankar, Udayaraj, additional, Patel, Seema, additional, Man, Anna, additional, Christmas, Natasha, additional, Rangasamy, Ravi, additional, Ladner, Richard, additional, Butt, Georgina, additional, Alvares, Wilson, additional, Gadi, Narasimha, additional, Power, Michael, additional, Wroath, Belinda, additional, Dynan, Kevin, additional, Wilson, David, additional, Crothers, Sarah, additional, Leonard, Catherine, additional, Hagan, Samantha, additional, Douris, Geraldine, additional, Vahidassr, Djamil, additional, Thompson, Alastair, additional, Gallen, Brian, additional, Mckenna, Shirley, additional, Edwards, Collette, additional, Mcgoldrick, Clare, additional, Bhattad, Murdi, additional, Kawafi, Khalil, additional, Morse, Deborah, additional, Jacob, Patricia, additional, Turner, Lisa, additional, Saravanan, Narayanamoorti, additional, Johnson, Linda, additional, Humphrey, Sadie, additional, Namushi, Robert, additional, Patel, Ramesh, additional, Mclaughlin, Jemma, additional, Omahony, Paul, additional, Osikominu, Esther, additional, Orefo, Chukwuka, additional, Mcdonald, Chisha, additional, Makanju, Esther, additional, Khan, Tabindah, additional, Appiatse, Grace, additional, Stone, Helena, additional, Augustin, Martia, additional, Wardale, Alicia, additional, Salehin, Maqsud, additional, Bailey, Duncan, additional, Garcia-Alen, Luciano, additional, Kalathil, Latheef, additional, Tinsley, Sarah, additional, Jones, Taya, additional, Amor, Kelly, additional, Ritchings, Andrew, additional, Margerum, Emma, additional, Horton, Jane, additional, Miller, Richard, additional, Gautam, Nireekshana, additional, Meir, Julie, additional, Jones, Amaryl, additional, Putteril, Janet, additional, Lepore, Mirella, additional, Gallifent, Rachel, additional, Arundell, Laura-Louise, additional, Mcredmond, Catherine, additional, Goulding, Alicia, additional, Nadarajan, Vivek, additional, Laurence, Julia, additional, Fung Lo, Su, additional, Melander, Sabina, additional, Nicholas, Paul, additional, Woodford, Elizabeth, additional, Mckenzie, Gillian, additional, Le, Vietland, additional, Crause, Jacolene, additional, Luder, Robert, additional, Bhargava, Maneesh, additional, Bhome, Girish, additional, Johnson, Venetia V, additional, Chesser, Dara, additional, Bridger, Hayley, additional, Murali, Elodie, additional, Scott, Jon, additional, Morrison, Susan, additional, Burns, Amy, additional, Graham, Julie, additional, Duffy, Madeline, additional, Ali, Khalid, additional, Pitcher, Emma, additional, Gaylard, Jane, additional, Newman, Julie, additional, Punnoose, Sunil, additional, Besley, Sarah, additional, Purohit, Kirtan, additional, Rees, Amy, additional, Davy, Mark, additional, Chohan, Osman, additional, Khan, Muhammad Fozan, additional, Walker, Rachel, additional, Murray, Vicky, additional, Bent, Charlotte, additional, Oakley, Susan, additional, Peixoto, Cassilda, additional, Jones, Suzanne, additional, Livingstone, Gaybrielle, additional, Butler, Fiona, additional, Bradfield, Sally, additional, Gordon, Laura, additional, Schmit, Jenneke, additional, Wijewardane, Anika, additional, Edmunds, Tineke, additional, Wills, Rebecca, additional, Medcalf, Catherine, additional, Argandona, Lucia, additional, Cuenoud, Larissa, additional, Hassan, Hanna, additional, Erumere, Esther, additional, Ocallaghan, Aidan, additional, Gompertz, Patrick, additional, Redjep, Ozlem, additional, Auld, Grace, additional, Song, Anna, additional, Tarkas, Tillana, additional, Kabash, Hashim, additional, and Hungwe, Rumbi, additional

Published
2019
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23. Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

Author

Hall, Claire E., primary, Yao, Zhi, additional, Choi, Minee, additional, Tyzack, Giulia E., additional, Serio, Andrea, additional, Luisier, Raphaelle, additional, Harley, Jasmine, additional, Preza, Elisavet, additional, Arber, Charlie, additional, Crisp, Sarah J., additional, Watson, P. Marc D., additional, Kullmann, Dimitri M., additional, Abramov, Andrey Y., additional, Wray, Selina, additional, Burley, Russell, additional, Loh, Samantha H.Y., additional, Martins, L. Miguel, additional, Stevens, Molly M., additional, Luscombe, Nicholas M., additional, Sibley, Christopher R., additional, Lakatos, Andras, additional, Ule, Jernej, additional, Gandhi, Sonia, additional, and Patani, Rickie, additional

Published
2017
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31. ARF6 Directs Axon Transport and Traffic of Integrins and Regulates Axon Growth in Adult DRG Neurons.

Author

Eva, Richard, Crisp, Sarah, Marland, Jamie R. K., Norman, Jim C., Kanamarlapudi, Venkateswarlu, ffrench-Constant, Charles, and Fawcett, James W.

Subjects
*INTEGRINS, *NERVOUS system regeneration, *AXONAL transport, *ENDOSOMES, *CELL membranes, *GENETIC regulation
Abstract

Integrins are involved in axon growth and regeneration. Manipulation of integrins is a route to promoting axon regeneration and understanding regeneration failure in the CNS. Expression of α9 integrin promotes axon regeneration, so we have investigated α9β1 trafficking and transport in axons and at the growth cone. We have previously found thatα9 andβ1 integrins traffic via Rab11-positive recycling endosomes in peripheral axons and growth cones. However, transport via Rab11 is slow, while rapid transport occurs in vesicles lacking Rab11. We have further studied α9 and β1 integrin transport and traffic in adult rat dorsal root ganglion axons and PC12 cells. Integrins are in ARF6 vesicles during rapid axonal transport and during trafficking in the growth cone. We report that rapid axonal transport of these integrins and their trafficking at the cell surface is regulated by ARF6. ARF6 inactivation by expression of ACAP1 leads to increased recycling of β1 integrins to the neuronal surface and to increased anterograde axonal transport. ARF6 activation by expression of the neuronal guanine nucleotide exchange factors, ARNO or EFA6, increases retrograde integrin transport in axons and increases integrin internalization. ARF6 inactivation increases integrin-mediated outgrowth, while activation decreases it. The coordinated changes in integrin transport and recycling resulting from ARF6 activation or inactivation are the probable mechanism behind this regulation of axon growth. Our data suggest a novel mechanism of integrin traffic and transport in peripheral axons, regulated by the activation state of ARF6, and suggest that ARF6 might be targeted to enhance integrin-dependent axon regeneration after injury. [ABSTRACT FROM AUTHOR]

Published
2012
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32. Endogenous Patterns of Activity Are Required for the Maturation of a Motor Network.

Author

Crisp, Sarah J., Evers, Jan Felix, and Bate, Michael

Subjects
*NERVOUS system, *EMBRYOLOGY, *SPINAL cord, *DROSOPHILA, *NEUROSCIENCES
Abstract

Many parts of the nervous system become active before development is complete, including the embryonic spinal cord. Remarkably, although the subject has been debated for over a century (Harrison, 1904), it is still unclear whether such activity is required for normal development of motor circuitry. In Drosophila, embryonic motor output is initially poorly organized, and coordinated crawling-like behavior gradually emerges over the subsequent phase of development. We show that reversibly blocking synaptic transmission during this phase severely delays the first appearance of coordinated movements. When we interfere with the pattern of neuronal firing during this period, coordination is also delayed or blocked. We conclude that there is a period during which endogenous patterns of neuronal activity are required for the normal development of motor circuits in Drosophila. [ABSTRACT FROM AUTHOR]

Published
2011
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33. Comparison of bifunctional chelates for 64Cu antibody imaging.

Author

Ferreira, Cara L., Yapp, Donald T. T., Crisp, Sarah, Sutherland, Brent W., W. Ng, Sylvia S., Gleave, Martin, Bensimon, Corinne, Jurek, Paul, and Kiefer, Garry E.

Abstract

PurposeImproved bifunctional chelates (BFCs) are needed to facilitate efficient 64Cu radiolabeling of monoclonal antibodies (mAbs) under mild conditions and to yield stable, target-specific agents. The utility of two novel BFCs, 1-Oxa-4,7,10-triazacyclododecane-5-S-(4-isothiocyanatobenzyl)-4,7,10-triacetic acid (p-SCN-Bn-Oxo-DO3A) and 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-4-S-(4-isothiocyanatobenzyl)-3,6,9-triacetic acid (p-SCN-Bn-PCTA), for mAb imaging with 64Cu were compared to the commonly used S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-tetraacetic acid (p-SCN-Bn-DOTA).MethodsThe BFCs were conjugated to trastuzumab, which targets the HER2/neu receptor. 64Cu radiolabeling of the conjugates was optimized. Receptor binding was analyzed using flow cytometry and radioassays. Finally, PET imaging and biodistribution studies were done in mice bearing either HER2/neu-positive or HER2/neu-negative tumors.Results64Cu-Oxo-DO3A- and PCTA-trastuzumab were prepared at room temperature in >95% radiochemical yield (RCY) in <30 min, compared to only 88% RCY after 2 h for the preparation of 64Cu-DOTA-trastuzumab under the same conditions. Cell studies confirmed that the immunoreactivity of the mAb was retained for each of the bioconjugates. In vivo studies showed that 64Cu-Oxo-DO3A- and PCTA-trastuzumab had higher uptake than the 64Cu-DOTA-trastuzumab at 24 h in HER2/neu-positive tumors, resulting in higher tumor to background ratios and better tumor images. By 40 h all three of the 64Cu-BFC-trastuzumab conjugates allowed for clear visualization of the HER2/neu-positive tumors but not the negative control tumor.ConclusionThe antibody conjugates of PCTA and Oxo-DO3A were shown to have superior 64Cu radiolabeling efficiency and stability compared to the analogous DOTA conjugate. In addition, 64Cu-PCTA and Oxo-DO3A antibody conjugates may facilitate earlier imaging with greater target to background ratios than the analogous 64Cu-DOTA antibody conjugates. [ABSTRACT FROM AUTHOR]

Published
2010
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34. Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

Author

Hall, Claire E, Yao, Zhi, Choi, Minee, Tyzack, Giulia E, Serio, Andrea, Luisier, Raphaelle, Harley, Jasmine, Preza, Elisavet, Arber, Charlie, Crisp, Sarah J, Watson, P Marc D, Kullmann, Dimitri M, Abramov, Andrey Y, Wray, Selina, Burley, Russell, Loh, Samantha HY, Martins, L Miguel, Stevens, Molly M, Luscombe, Nicholas M, Sibley, Christopher R, Lakatos, Andras, Ule, Jernej, Gandhi, Sonia, Patani, Rickie, Crisp, Sarah [0000-0002-0007-7775], Loh, Sam [0000-0001-5073-6065], Lakatos, Andras [0000-0002-1301-2292], and Apollo - University of Cambridge Repository

Subjects
amyotrophic lateral sclerosis (ALS), Mutation/genetics, Cell Survival, TDP-43, Neurogenesis, Induced Pluripotent Stem Cells, Endoplasmic Reticulum, Models, Biological, AMYOTROPHIC-LATERAL-SCLEROSIS, GLUTAMATE, ENDOPLASMIC-RETICULUM STRESS, Valosin Containing Protein, Report, Mitochondria/metabolism, REVEALS, disease modeling, Humans, Amyotrophic Lateral Sclerosis/metabolism, Endoplasmic Reticulum/metabolism, lcsh:QH301-705.5, Nerve Degeneration/pathology, Membrane Potential, Mitochondrial, Motor Neurons, DNA-Binding Proteins/metabolism, Science & Technology, MUTATIONS, Amyotrophic Lateral Sclerosis, Motor Neurons/pathology, Cell Biology, ER STRESS, Endoplasmic Reticulum Stress, Mitochondria, MUTANT SOD1, DNA-Binding Proteins, Induced Pluripotent Stem Cells/metabolism, Oxidative Stress, Phenotype, Synapses/pathology, lcsh:Biology (General), astrocytes (ACs), Astrocytes/pathology, Astrocytes, Mutation, Nerve Degeneration, Synapses, motor neurons (MNs), induced pluripotent stem cells (iPSCs), Life Sciences & Biomedicine, Valosin Containing Protein/metabolism
Abstract

Summary Motor neurons (MNs) and astrocytes (ACs) are implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but their interaction and the sequence of molecular events leading to MN death remain unresolved. Here, we optimized directed differentiation of induced pluripotent stem cells (iPSCs) into highly enriched (> 85%) functional populations of spinal cord MNs and ACs. We identify significantly increased cytoplasmic TDP-43 and ER stress as primary pathogenic events in patient-specific valosin-containing protein (VCP)-mutant MNs, with secondary mitochondrial dysfunction and oxidative stress. Cumulatively, these cellular stresses result in synaptic pathology and cell death in VCP-mutant MNs. We additionally identify a cell-autonomous VCP-mutant AC survival phenotype, which is not attributable to the same molecular pathology occurring in VCP-mutant MNs. Finally, through iterative co-culture experiments, we uncover non-cell-autonomous effects of VCP-mutant ACs on both control and mutant MNs. This work elucidates molecular events and cellular interplay that could guide future therapeutic strategies in ALS., Graphical Abstract, Highlights • Robust and enriched motor neurogenesis and astrogliogenesis from human iPSCs • VCP-mutant motor neurons show TDP-43 mislocalization and ER stress as early pathogenic events • VCP-mutant astrocytes exhibit a cell-autonomous survival phenotype • VCP-mutations perturb the ability of astrocytes to support motor neuron survival, Hall et al. use iPSCs to examine the sequence of events by which motor neurons degenerate in a genetic form of ALS. They find that astrocytes, a type of supportive cell, also degenerate under these conditions. The ALS-causing mutation disrupts the ability of astrocytes to promote survival of motor neurons.

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35. WDR45 Mutation in Atypical Rett Syndrome with Brain Iron Accumulation.

Author

Crisp, Sarah J., Meyer, Esther, Gregory, Allison, Archer, Hayley, Hayflick, Susan, Kurian, Manju A., and Silva, Rajith

Subjects
*RETT syndrome, *MOTOR ability, *COMMUNICATIVE disorders, *GENETIC counseling
Abstract

The article presents a case study of a young woman who showed signs of Rett syndrome. It notes that the patient suffered deterioration in her communication and motor skills. A historical background of the disease and the present condition of the patient is discussed. It is concluded that there is a hard time in predicting the disease course and provide accurate genetic counseling to the family.

Published
2015
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36. Motor Circuit Development Requires Patterned Activity.

Author

Crisp, Sarah J., Evers, Jan Felix, and Bate, Michael

Subjects
*NERVOUS system, *NEUROSCIENCES
Abstract

The article reports on a research according to which motor circuit development requires patterned activity in the nervous system.

Published
2011

37. Antibody-mediated central nervous system diseases

Author

Angela Vincent, Sarah Crisp, Maria Pia Giannoccaro, Giannoccaro MP, Crisp SJ, Vincent A., Crisp, Sarah [0000-0002-0007-7775], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, CASPR2, Central nervous system, Review Article, 03 medical and health sciences, 0302 clinical medicine, Autoantibody, Neurotransmitter receptor, Glioma, Medicine, Glycine receptor, Autoimmune encephalitis, biology, Clinical neuroscience, neurodevelopment, business.industry, General Neuroscience, medicine.disease, NMDA receptor, autoimmune encephalitis, 030104 developmental biology, medicine.anatomical_structure, biology.protein, LGI1, Neurology (clinical), Antibody, business, Neuroscience, Autoantibody, autoimmune encephalitis, neurodevelopment, NMDA receptor, LGI1, CASPR2, 030217 neurology & neurosurgery
Abstract

Antibody-mediated central nervous system diseases are a relatively new area of clinical neuroscience with growing impact. Their recognition has challenged the dogma of the blood–brain barrier preventing antibody access into the central nervous system. The antibodies discovered so far are mainly against neurotransmitter receptors (e.g. N-methyl-d-aspartate and glycine receptors) and ion channel–associated proteins (leucine-rich glioma inactivated protein 1 and contactin-associated protein 2) and are expressed on the surface of neuronal synapses and elsewhere. The disorders are reversible with immunotherapies that reduce antibody levels. Although rare, the identification of these disorders in clinical practice has made central nervous system autoimmune diseases a consideration in the differential diagnoses of many clinical presentations. There is still much to learn about the aetiology of the diseases and the mechanisms by which the antibodies act, the neuronal and glial changes that follow antibody-attack, and the compensatory changes that may be required to ensure good recovery.

Published
2021
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42. Plasma cell depletion with bortezomib in the treatment of refractory N-methyl-d-aspartate (NMDA) receptor antibody encephalitis. Rational developments in neuroimmunological treatment

Author

Keddie, S, Crisp, SJ, Blackaby, J, Cox, A, Coles, A, Hart, M, Church, AJ, Vincent, A, Zandi, M, Lunn, MP, Crisp, Sarah [0000-0002-0007-7775], Coles, Alasdair [0000-0003-4738-0760], and Apollo - University of Cambridge Repository

Subjects
Adult, Anti-N-Methyl-D-Aspartate Receptor Encephalitis, plasma cell, encephalitis, bortezomib, Plasma Cells, Antineoplastic Agents, neuroimmunology, Receptors, N-Methyl-D-Aspartate, Treatment Outcome, NMDA, hemic and lymphatic diseases, Humans, Female
Abstract

BACKGROUND AND PURPOSE: The aim was to assess the therapeutic potential of bortezomib in the treatment of refractory N-methyl-d-aspartate receptor (NMDAR) antibody encephalitis and its potential in other immune-mediated, B-cell-driven neurological diseases. METHODS: Two cases of severe NMDAR antibody encephalitis, resistant to first and second line therapy with steroids, intravenous immunoglobulins, plasma exchange, cyclophosphamide and rituximab, were treated with four and five cycles of 1.3 mg/m2 bortezomib at 350 and 330 days following initial presentation. RESULTS: Both patients showed significant clinical improvement with reductions of NMDAR antibody titres following bortezomib treatment. This is the first case in the literature where the NMDAR antibody level was undetectable following treatment with bortezomib. CONCLUSION: Bortezomib's unique ability to target long-lived autoreactive plasma cells appears to be a useful adjunct to standard second line immunosuppressive therapy in treatment-refractory NMDAR antibody encephalitis. The drug's pharmacodynamics, cell targeting and mechanism of action are reviewed, and it is postulated that bortezomib may be useful in a host of B-cell-driven neuroimmunological diseases.

Published
2018

43. β-Propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation.

Author

Hayflick SJ, Kruer MC, Gregory A, Haack TB, Kurian MA, Houlden HH, Anderson J, Boddaert N, Sanford L, Harik SI, Dandu VH, Nardocci N, Zorzi G, Dunaway T, Tarnopolsky M, Skinner S, Holden KR, Frucht S, Hanspal E, Schrander-Stumpel C, Mignot C, Héron D, Saunders DE, Kaminska M, Lin JP, Lascelles K, Cuno SM, Meyer E, Garavaglia B, Bhatia K, de Silva R, Crisp S, Lunt P, Carey M, Hardy J, Meitinger T, Prokisch H, and Hogarth P

Subjects
Adolescent, Adult, Cohort Studies, Female, Genetic Diseases, X-Linked diagnosis, Humans, Male, Middle Aged, Mutation genetics, Neurodegenerative Diseases diagnosis, Young Adult, Brain metabolism, Carrier Proteins genetics, Genetic Diseases, X-Linked genetics, Genetic Diseases, X-Linked metabolism, Iron metabolism, Neurodegenerative Diseases genetics, Neurodegenerative Diseases metabolism
Abstract

Neurodegenerative disorders with high iron in the basal ganglia encompass an expanding collection of single gene disorders collectively known as neurodegeneration with brain iron accumulation. These disorders can largely be distinguished from one another by their associated clinical and neuroimaging features. The aim of this study was to define the phenotype that is associated with mutations in WDR45, a new causative gene for neurodegeneration with brain iron accumulation located on the X chromosome. The study subjects consisted of WDR45 mutation-positive individuals identified after screening a large international cohort of patients with idiopathic neurodegeneration with brain iron accumulation. Their records were reviewed, including longitudinal clinical, laboratory and imaging data. Twenty-three mutation-positive subjects were identified (20 females). The natural history of their disease was remarkably uniform: global developmental delay in childhood and further regression in early adulthood with progressive dystonia, parkinsonism and dementia. Common early comorbidities included seizures, spasticity and disordered sleep. The symptoms of parkinsonism improved with l-DOPA; however, nearly all patients experienced early motor fluctuations that quickly progressed to disabling dyskinesias, warranting discontinuation of l-DOPA. Brain magnetic resonance imaging showed iron in the substantia nigra and globus pallidus, with a 'halo' of T1 hyperintense signal in the substantia nigra. All patients harboured de novo mutations in WDR45, encoding a beta-propeller protein postulated to play a role in autophagy. Beta-propeller protein-associated neurodegeneration, the only X-linked disorder of neurodegeneration with brain iron accumulation, is associated with de novo mutations in WDR45 and is recognizable by a unique combination of clinical, natural history and neuroimaging features.

Published
2013
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