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2. Parental developmental experience affects vocal learning in offspring

Author

Fanny-Linn H. Kraft, Ondi L. Crino, Saidat O. Adeniran-Obey, Raven A. Moraney, David F. Clayton, Julia M. George, and Katherine L. Buchanan

Subjects
Birdsong, Developmental stress, Gene expression, Intergenerational effects, Transgenerational plasticity, Zebra finch, Medicine, Science
Abstract

Abstract Cultural and genetic inheritance combine to enable rapid changes in trait expression, but their relative importance in determining trait expression across generations is not clear. Birdsong is a socially learned cognitive trait that is subject to both cultural and genetic inheritance, as well as being affected by early developmental conditions. We sought to test whether early-life conditions in one generation can affect song acquisition in the next generation. We exposed one generation (F1) of nestlings to elevated corticosterone (CORT) levels, allowed them to breed freely as adults, and quantified their son’s (F2) ability to copy the song of their social father. We also quantified the neurogenetic response to song playback through immediate early gene (IEG) expression in the auditory forebrain. F2 males with only one corticosterone-treated parent copied their social father’s song less accurately than males with two control parents. Expression of ARC in caudomedial nidopallium (NCM) correlated with father-son song similarity, and patterns of expression levels of several IEGs in caudomedial mesopallium (CMM) in response to father song playback differed between control F2 sons and those with a CORT-treated father only. This is the first study to demonstrate that developmental conditions can affect social learning and neurogenetic responses in a subsequent generation.

Published
2024
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3. Local ablation disrupts immune evasion in pancreatic cancer

Author

Musiu, Chiara, Adamo, Annalisa, Caligola, Simone, Agostini, Antonio, Frusteri, Cristina, Lupo, Francesca, Boschi, Federico, Busato, Alice, Poffe, Ornella, Anselmi, Cristina, Vella, Antonio, Wang, Tian, Dusi, Silvia, Piro, Geny, Carbone, Carmine, Tortora, Giampaolo, Marzola, Pasquina, D'Onofrio, Mirko, Crinò, Stefano Francesco, Corbo, Vincenzo, Scarpa, Aldo, Salvia, Roberto, Malleo, Giuseppe, Lionetto, Gabriella, Sartoris, Silvia, Ugel, Stefano, Bassi, Claudio, Bronte, Vincenzo, Paiella, Salvatore, and De Sanctis, Francesco

Published
2025
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4. On K3-fibred LARGE Volume Scenario with de Sitter vacua from anti-D3-branes

Author

AbdusSalam, Shehu, Crinò, Chiara, and Shukla, Pramod

Subjects
High Energy Physics - Theory
Abstract

In the context of type IIB superstring compactifications on K3-fibred (weak) Swiss-cheese Calabi Yau (CY) orientifolds, we consider the realisation of de Sitter vacua obtained through the introduction of an anti-D3-brane at the tip of a highly warped throat of Klebanov-Strassler type. Aiming to have a concrete global realisation, we perform a systematic search for the CY threefolds with $2 < h^{1,1} < 5$ arising from the Kreuzer-Skarke database, which satisfy the minimal requirements of being K3-fibred and suitable for moduli stabilisation within the LARGE Volume Scenario (LVS). In this context, after scanning the set of K3-fibred CY threefolds with a so-called diagonal del-Pezzo divisor needed for LVS, we realise that one of the main challenging requirements for having anti-D3-brane uplifting is to find a suitable orientifold involution which can simultaneously result in a sufficient large $D3$ tadpole charge along with the presence of suitable $O3$-planes. In our detailed analysis (limited to) using the CY threefolds with small $h^{1,1}$, we observe that these topological requirements rule out most of the CY geometries leading to only few possibly suitable candidates for the purpose of anti-D3-brane uplifting. Subsequently, we present a global model using one such explicit K3-fibred CY threefold with $h^{1,1}=4$ in which all the moduli can be consistently stabilised in a de Sitter minimum of the scalar potential., Comment: v2: 40 pages, 1 figure, improved version to appear in JHEP; v1: 37 pages, 1 figure

Published
2022
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5. The 1st i-EUS consensus on the management of pancreatic fluid collections – Part 2

Author

Aragona, Giovanni, Arcidiacono, Paolo Giorgio, Arvanitaki, Marianna, Badas, Roberta, Barresi, Luca, Berretti, Debora, Bocus, Paolo, Camellini, Lorenzo, Cintorino, Davide, Cugia, Luigi, Dabizzi, Emanuele, De Angelis, Claudio Giovanni, Blanco, Giovanna Del Vecchio, Matteo, Francesco Maria Di, Mitri, Roberto Di, Ercolani, Giorgio, Falconi, Massimo, Fantin, Alberto, Ligresti, Dario, Macchiarelli, Raffaele, Mangiafico, Santi, Mangiavillano, Benedetto, Manno, Mauro, Maruzzelli, Luigi, Marzioni, Marco, Pedicini, Vittorio, Piras, Enrico, Pollino, Valeria, Sethi, Amrita, Siddiqui, Uzma, Togliani, Thomas, Traina, Mario, Tringali, Alberto, Venezia, Giovanna, Zerbi, Alessandro, Capurso, Gabriele, Coluccio, Chiara, Rizzo, Giacomo Emanuele Maria, Crinò, Stefano Francesco, Cucchetti, Alessandro, Facciorusso, Antonio, Hassan, Cesare, Amato, Arnaldo, Auriemma, Francesco, Bertani, Helga, Binda, Cecilia, Cipolletta, Fabio, Forti, Edoardo, Fugazza, Alessandro, Lisotti, Andrea, Maida, Marcello, Sinagra, Emanuele, Sbrancia, Monica, Spadaccini, Marco, Tacelli, Matteo, Vanella, Giuseppe, Anderloni, Andrea, Fabbri, Carlo, and Tarantino, Ilaria

Published
2024
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7. A Database of Calabi-Yau Orientifolds and the Size of D3-Tadpoles

Author

Crinò, Chiara, Quevedo, Fernando, Schachner, Andreas, and Valandro, Roberto

Subjects
High Energy Physics - Theory
Abstract

The classification of 4D reflexive polytopes by Kreuzer and Skarke allows for a systematic construction of Calabi-Yau hypersurfaces as fine, regular, star triangulations (FRSTs). Until now, the vastness of this geometric landscape remains largely unexplored. In this paper, we construct Calabi-Yau orientifolds from holomorphic reflection involutions of such hypersurfaces with Hodge numbers $h^{1,1}\leq 12$. In particular, we compute orientifold configurations for all favourable FRSTs for $h^{1,1}\leq 7$, while randomly sampling triangulations for each pair of Hodge numbers up to $h^{1,1}=12$. We find explicit string compactifications on these orientifolded Calabi-Yaus for which the D3-charge contribution coming from O$p$-planes grows linearly with the number of complex structure and K\"ahler moduli. We further consider non-local D7-tadpole cancellation through Whitney branes. We argue that this leads to a significant enhancement of the total D3-tadpole as compared to conventional $\mathrm{SO}(8)$ stacks with $(4+4)$ D7-branes on top of O7-planes. In particular, before turning-on worldvolume fluxes, we find that the largest D3-tadpole in this class occurs for Calabi-Yau threefolds with $(h^{1,1}_{+},h^{1,2}_{-})=(11,491)$ with D3-brane charges $|Q_{\text{D3}}|=504$ for the local D7 case and $|Q_{\text{D3}}|=6,664$ for the non-local Whitney branes case, which appears to be large enough to cancel tadpoles and allow fluxes to stabilise all complex structure moduli. Our data is publicly available under http://github.com/AndreasSchachner/CY_Orientifold_database ., Comment: 30 pages plus appendices, 5 figures

Published
2022
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8. The i-EUS consensus on the management of pancreatic fluid collections – Part 1

Author

Aragona, Giovanni, Arcidiacono, Paolo Giorgio, Arvanitaki, Marianna, Badas, Roberta, Barresi, Luca, Berretti, Debora, Bocus, Paolo, Camellini, Lorenzo, Cintorino, Davide, Cugia, Luigi, Dabizzi, Emanuele, De Angelis, Claudio Giovanni, Blanco, Giovanna Del Vecchio, Matteo, Francesco Maria Di, Mitri, Roberto Di, Ercolani, Giorgio, Falconi, Massimo, Fantin, Alberto, Ligresti, Dario, Macchiarelli, Raffaele, Mangiafico, Santi, Mangiavillano, Benedetto, Manno, Mauro, Maruzzelli, Luigi, Marzioni, Marco, Pedicini, Vittorio, Piras, Enrico, Pollino, Valeria, Sethi, Amrita, Siddiqui, Uzma, Togliani, Thomas, Traina, Mario, Tringali, Alberto, Venezia, Giovanna, Zerbi, Alessandro, Capurso, Gabriele, Rizzo, Giacomo Emanuele Maria, Coluccio, Chiara, Crinò, Stefano Francesco, Cucchetti, Alessandro, Facciorusso, Antonio, Hassan, Cesare, Amato, Arnaldo, Auriemma, Francesco, Bertani, Helga, Binda, Cecilia, Cipolletta, Fabio, Forti, Edoardo, Fugazza, Alessandro, Lisotti, Andrea, Maida, Marcello, Sinagra, Emanuele, Sbrancia, Monica, Spadaccini, Marco, Tacelli, Matteo, Vanella, Giuseppe, Anderloni, Andrea, Fabbri, Carlo, and Tarantino, Ilaria

Published
2024
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10. Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia

Author

Stefano Zucchini, Stefano Tumini, Andrea Enzo Scaramuzza, Riccardo Bonfanti, Maurizio Delvecchio, Roberto Franceschi, Dario Iafusco, Lorenzo Lenzi, Enza Mozzillo, Stefano Passanisi, Claudia Piona, Ivana Rabbone, Novella Rapini, Andrea Rigamonti, Carlo Ripoli, Giuseppina Salzano, Silvia Savastio, Riccardo Schiaffini, Angela Zanfardino, Valentino Cherubini, Diabetes Study Group of the Italian Society for Pediatric Endocrinology Diabetes, Albino Claudia Accursia, Aloe Monica, Anzelotti Maria Teresa, Arnaldi Claudia, Barbetti Fabrizio, Bassi Marta, Berioli Maria Giulia, Bernardini Luca, Bertelli Enrica, Biagioni Martina, Bobbio Adriana, Bombaci Bruno, Bonfanti Riccardo, Bonura Clara, Bracciolini Giulia Patrizia, Bruzzese Mariella, Bruzzi Patrizia, Buono Pietro, Buscarino Piera, Cadario Francesco, Calcaterra Valeria, Calzi Elena, Cappa Marco, Cardani Roberta, Cardella Francesca, Cardinale Giuliana Marcella, Casertano Alberto, Castorani Valeria, Cauvin Vittoria, Cenciarelli Valentina, Ceruti Franco, Cherubini Valentino, Chiarelli Francesco, Chiari Giovanni, Cianfarani Stefano, Cicchetti Mario, Cipriano Paola, Cirillo Dante, Citriniti Felice, Coccioli Maria Susanna, Confetto Santino, Contreas Giovanna, Coro Anna, Correddu Antonella, Corsini Elisa, Crino’ Antonino, d’Annunzio Giuseppe, De Berardinis Fiorella, De Donno Valeria, De Filippo Gianpaolo, De Marco Rosaria, De Sanctis Luisa, Del Duca Elisabetta, Delvecchio Maurizio, Deodati Annalisa, Di Bonito Procolo, Di Candia Francesca, Faleschini Elena, Fattorusso Valentina, Favia Anna, Federico Giovanni, Felappi Barbara, Ferrari Mara, Ferrito Lucia, Fichera Graziella, Fontana Franco, Fornari Elena, Franceschi Roberto, Franco Francesca, Franzese Adriana, Frongia Anna Paola, Frontino Giulio, Gaiero Alberto, Galassi Sabrina Maria, Gallo Francesco, Gargantini Luigi, Giani Elisa, Gortan Anna Jolanda, Graziani Vanna, Grosso Caterina, Gualtieri Antonella, Guasti Monica, Guerraggio Lucia Paola, Guzzetti Chiara, Iafusco Dario, Iannicelli Gennaro, Iezzi Maria Laura, Ignaccolo Maria Giovanna, Innaurato Stefania, Inzaghi Elena, Iovane Brunella, Iughetti Lorenzo, Kaufmann Peter, La Loggia Alfonso, Lambertini Anna Giulia, Lapolla Rosa, Lasagni Anna, Lazzaro Nicola, Lazzeroni Pietro, Lenzi Lorenzo, Lera Riccardo, Levantini Gabriella, Lezzi Marilea, Lia Rosanna, Liguori Alice, Lo Presti Donatella, Lombardo Fortunato, Lonero Antonella, Longhi Silvia, Lorubbio Antonella, Lucchesi Sonia, Maccioni Rosella, Macedoni Maddalena, Macellaro Patrizia Cristiana, Madeo Simona Filomena, Maffeis Claudio, Mainetti Benedetta, Maltoni Giulio, Mameli Chiara, Mammì Francesco, Manca Bitti Maria Luisa, Mancioppi Valentina, Manco Melania, Marigliano Marco, Marino Monica, Marsciani Alberto, Matteoli Maria Cristina, Mazzali Elena, Minute Marta, Minuto Nicola, Monti Sara, Morandi Anita,, Morganti Gianfranco, Morotti Elisa, Mozzillo Enza, Musolino Gianluca, Olivieri Francesca, Ortolani Federica, Pampanini Valentina, Pardi Daniela, Pascarella Filomena, Pasquino Bruno, Passanisi Stefano, Patera Ippolita Patrizia, Pedini Annalisa, Pennati Maria Cristina, Peruzzi Sonia, Peverelli Paola, Pezzino Giulia, Piccini Barbara, Piccinno Elvira Eugenia Rosaria, Piona Claudia, Piredda Gavina, Piscopo Alessia, Pistone Carmelo, Pozzi Erica, Prandi Elena, Predieri Barbara, Prudente Sabrina, Pulcina Anna, Rabbone Ivana, Randazzo Emioli, Rapini Novella, Reinstadler Petra, Riboni Sara, Ricciardi Maria Rossella, Rigamonti Andrea, Ripoli Carlo, Rossi Virginia, Rossi Paolo, Rutigliano Irene, Sabbion Alberto, Salvatoni Alessandro, Salvo Caterina, Salzano Giuseppina, Sanseviero Mariateresa, Savastio Silvia, Savini Rosanna, Scanu Mariapiera, Scaramuzza Andrea Enzo, Schiaffini Riccardo, Schiavone Maurizio, Schieven Eleonardo, Scipione Mirella, Secco Andrea, Silvestri Francesca, Siri Giulia, Sogno Valin Paola, Sordelli Silvia, Spiri Daniele, Stagi Stefano, Stamati Filomena Andreina, Suprani Tosca, Talarico Valentina, Tiberi Valentina, Timpanaro Tiziana Antonia Lucia, Tinti Davide, Tirendi Antonina, Tomaselli Letizia Grazia, Toni Sonia, Torelli Cataldo, Tornese Gianluca, Trada Michela,, Trettene Adolfo Andrea, Tumini Stefano, Tumminelli Marilena, Valerio Giuliana, Vandelli Sara, Ventrici Claudia, Zampolli Maria, Zanatta Manuela, Zanfardino Angela, Zecchino Clara, Zonca Silvia, and Zucchini Stefano

Subjects
adolescents, automated insulin delivery, children, hypoglycemia, glucagon, oral glucose, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

There has been continuous progress in diabetes management over the last few decades, not least due to the widespread dissemination of continuous glucose monitoring (CGM) and automated insulin delivery systems. These technological advances have radically changed the daily lives of people living with diabetes, improving the quality of life of both children and their families. Despite this, hypoglycemia remains the primary side-effect of insulin therapy. Based on a systematic review of the available scientific evidence, this paper aims to provide evidence-based recommendations for recognizing, risk stratifying, treating, and managing patients with hypoglycemia. The objective of these recommendations is to unify the behavior of pediatric diabetologists with respect to the timely recognition and prevention of hypoglycemic episodes and the correct treatment of hypoglycemia, especially in patients using CGM or advanced hybrid closed-loop systems. All authors have long experience in the specialty and are members of the Italian Society of Pediatric Endocrinology and Diabetology. The goal of treating hypoglycemia is to raise blood glucose above 70 mg/dL (3.9 mmol/L) and to prevent further decreases. Oral glucose at a dose of 0.3 g/kg (0.1 g/kg for children using “smart pumps” or hybrid closed loop systems in automated mode) is the preferred treatment for the conscious individual with blood glucose

Published
2024
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12. RNA in cardiovascular disease: A new frontier of personalized medicine

Author

Abdul-Rahman, Toufik, Lizano-Jubert, Ileana, Bliss, Zarah Sophia Blake, Garg, Neil, Meale, Emily, Roy, Poulami, Crino, Salvatore Antonio, Deepak, Bethineedi Lakshmi, Miteu, Goshen David, Wireko, Andrew Awuah, Qadeer, Abdul, Condurat, Alexandra, Tanasa, Andra Diana, Pyrpyris, Nikolaos, Sikora, Kateryna, Horbas, Viktoriia, Sood, Aayushi, Gupta, Rahul, and Lavie, Carl J.

Published
2024
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14. On de Sitter String Vacua from Anti-D3-Branes in the Large Volume Scenario

Author

Crinò, Chiara, Quevedo, Fernando, and Valandro, Roberto

Subjects
High Energy Physics - Theory
Abstract

We consider de Sitter vacua realised in concrete type IIB Calabi-Yau compactifications with an anti D3-brane at the tip of a warped throat of Klebanov-Strassler type. The K\"ahler moduli are stabilised together with the complex structure modulus of the warped throat. The volume is exponentially large as in the large volume scenario (LVS). We analyse the conditions on the parameters of the EFT such that they are in the region of validity of our approximations, there are no runaway problems and the vacua satisfy all consistency constraints, such as tadpole cancellation. We illustrate our results with an explicit Calabi-Yau orientifold with two K\"ahler moduli and one antibrane on top of an O3-plane in a warped throat, that has the goldstino as its only massless state. The moduli are stabilised with $g_s\sim 0.2$ and volume $\mathcal{V}\sim 10^4$ in string units, justifying the approximation used to derive the corresponding EFT. Although the model lacks chiral matter, it is presented as a proof of concept, chosen to be the simplest realisation of antibrane uplift., Comment: 32 pages, 2 figures

Published
2020
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16. Reflecting on the YouthMappers Movement

Author

Anderson, Jennings, Blevins, Chad, Cowan, Nuala, Carney-Nedelman, Dara, Clark, Courtney, Crino, Michael, Engstrom, Ryan, Hinton, Richard, Mann, Michael, McCusker, Brent, Nealon, Rory, Solís, Patricia, Zeballos, Marcela, Solís, Patricia, editor, and Zeballos, Marcela, editor

Published
2023
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17. Endoscopic ultrasound-guided drainage of pancreatic collections with dedicated metal stents: A nationwide, multicenter, propensity score-matched comparison

Author

Binda, Cecilia, Petrone, Maria Chiara, Berretti, Debora, Macchiarelli, Raffaele, Lovera, Mauro, Attili, Fabia, D'Errico, Francesca, Brancaccio, Mario Luciano, Redaelli, Alessandro, Tasini, Enrico, Ballarè, Marco, Coppola, Franco, Leone, Nicola, Grassia, Roberto, Fusaroli, Pietro, DeAngelis, Claudio, Cipolletta, Fabio, Manno, Mauro, Badas, Roberta, Pollino, Valeria, Camellini, Lorenzo, Bernardoni, Laura, Conte, Elisabetta, Lisotti, Andrea, Mutignani, Massimiliano, Traina, Mario, Arcidiacono, Paolo Giorgio, Coluccio, Chiara, Facciorusso, Antonio, Forti, Edoardo, De Nucci, Germana, Mitri, Roberto Di, Togliani, Thomas, Cugia, Luigi, Ofosu, Andrew, Anderloni, Andrea, Tarantino, Ilaria, Fabbri, Carlo, and Crinò, Stefano Francesco

Published
2024
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19. Perioperative NALIRIFOX in patients with resectable pancreatic ductal adenocarcinoma: The open-label, multicenter, phase II nITRO trial

Author

Melisi, Davide, Zecchetto, Camilla, Merz, Valeria, Malleo, Giuseppe, Landoni, Luca, Quinzii, Alberto, Casalino, Simona, Fazzini, Federica, Gaule, Marina, Pesoni, Camilla, Casetti, Luca, Esposito, Alessandro, Marchegiani, Giovanni, Piazzola, Cristiana, D’Onofrio, Mirko, de Robertis, Riccardo, Gabbrielli, Armando, Bernardoni, Laura, Crino, Stefano F., Pietrobono, Silvia, Luchini, Claudio, Aliberti, Camillo, Martignoni, Guido, Milleri, Stefano, Butturini, Giovanni, Scarpa, Aldo, Salvia, Roberto, and Bassi, Claudio

Published
2024
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22. Endoscopic Ultrasound-guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma

Author

Alfieri, Sergio, Arcidiacono, Paolo Giorgio, Arvanitakis, Marianna, Battistella, Anna, Bernadroni, Laura, Brink, Lene, Cintolo, Marcello, Conti Bellocchi, Maria Cristina, Davì, Maria Vittoria, Deguelte, Sophie, Deprez, Pierre, Deviere, Jaques, Ewald, Jacques, Fabbri, Carlo, Ferrari, Giovanni, Furnica, Raluca Maria, Gabbrielli, Armando, Garcés-Duran, Rodrigo, Giovannini, Marc, Gonda, Tamas, Gornals, Joan B., Marx, Mariola, Mazzola, Michele, Mutignani, Massimiliano, Ofosu, Andrew, Pereira, Stephan P., Perrier, Marine, Przybylkowski, Adam, Repici, Alessandro, Sundaram, Sridhar, Tripodi, Giulia, Crinò, Stefano Francesco, Napoleon, Bertrand, Facciorusso, Antonio, Lakhtakia, Sundeep, Borbath, Ivan, Caillol, Fabrice, Do-Cong Pham, Khanh, Rizzatti, Gianenrico, Forti, Edoardo, Palazzo, Laurent, Belle, Arthur, Vilmann, Peter, van Laethem, Jean-Luc, Mohamadnejad, Mehdi, Godat, Sebastien, Hindryckx, Pieter, Benson, Ariel, Tacelli, Matteo, De Nucci, Germana, Binda, Cecilia, Kovacevic, Bojan, Jacob, Harold, Partelli, Stefano, Falconi, Massimo, Salvia, Roberto, Landoni, Luca, and Larghi, Alberto

Published
2023
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23. Study protocol for a multicenter randomized controlled trial to compare radiofrequency ablation with surgical resection for treatment of pancreatic insulinoma

Author

Crinò, Stefano Francesco, Partelli, Stefano, Napoleon, Bertrand, Conti Bellocchi, Maria Cristina, Facciorusso, Antonio, Salvia, Roberto, Forti, Edoardo, Cintolo, Marcello, Mazzola, Michele, Ferrari, Giovanni, Carrara, Silvia, Repici, Alessandro, Zerbi, Alessandro, Lania, Andrea, Tacelli, Matteo, Arcidiacono, Paolo Giorgio, Falconi, Massimo, Larghi, Alberto, Rizzatti, Gianenrico, Alfieri, Sergio, Panzuto, Francesco, Hindryckx, Pieter, Berrevoet, Frederik, Lapauw, Bruno, Lakhtakia, Sundeep, Sundaram, Sridhar, Samanta, Jayanta, Rastogi, Ashu, and Landoni, Luca

Published
2023
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27. Endoscopic ultrasound fine-needle biopsy to assess DAXX/ATRX expression and alternative lengthening of telomeres status in non-functional pancreatic neuroendocrine tumors

Author

Mastrosimini, Maria Gaia, Manfrin, Erminia, Remo, Andrea, De Bellis, Mario, Parisi, Alice, Pedron, Serena, Luchini, Claudio, Brunelli, Matteo, Ammendola, Serena, Bernardoni, Laura, Conti Bellocchi, Maria Cristina, Gabbrielli, Armando, Facciorusso, Antonio, Pea, Antonio, Landoni, Luca, Scarpa, Aldo, and Crinò, Stefano Francesco

Published
2023
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28. Regret affects the choice between neoadjuvant therapy and upfront surgery for potentially resectable pancreatic cancer

Author

Alfieri, Sergio, Amato, Arnaldo, Amisano, Marco, Anderloni, Andrea, Maestri, Antonio, Coluccio, Chiara, Brandi, Giovanni, Casadei-Gardini, Andrea, Cennamo, Vincenzo, Crinò, Stefano Francesco, Valle, Raffaele Dalla, De Angelis, Claudio, Di Battista, Monica, Di Maio, Massimo, Di Marco, Mariacristina, Di Marco, Marco, Di Matteo, Francesco, Di Mitri, Roberto, Ettorre, Giuseppe Maria, Facciorusso, Antonio, Farina, Gabriella, Ferrari, Giovanni, Fornaro, Lorenzo, Frigerio, Isabella, Frisone, Daniele, Fuccio, Lorenzo, Gardini, Andrea, Garufi, Carlo, Giampieri, Riccardo, Grazi, Gian Luca, Jovine, Elio, Kauffmann, Emanuele, Langella, Serena, Larghi, Alberto, Manno, Mauro, Marciano, Emanuele, Marzioni, Marco, Merighi, Alberto, Mutignani, Massimiliano, Nardo, Bruno, Niger, Monica, Palmisano, Valentina, Partelli, Stefano, Pinto, Carmine, Piras, Enrico, Rapposelli, Ilario Giovanni, Reni, Michele, Ricci, Claudio, Rimassa, Lorenza, Siena, Salvatore, Spada, Cristiano, Sperti, Elisa, Spezzaferro, Mariangela, Sposito, Carlo, Tamberi, Stefano, Troisi, Roberto, Veneroni, Luigi, Vivarelli, Marco, Zerbi, Alessandro, Cucchetti, Alessandro, Djulbegovic, Benjamin, Crippa, Stefano, Hozo, Iztok, Sbrancia, Monica, Tsalatsanis, Athanasios, Binda, Cecilia, Fabbri, Carlo, Salvia, Roberto, Falconi, Massimo, and Ercolani, Giorgio

Published
2023
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29. EUS-guided gastroenterostomy using a novel electrocautery lumen apposing metal stent for treatment of gastric outlet obstruction (with video)

Author

Mangiavillano, Benedetto, Larghi, Alberto, Vargas-Madrigal, Jorge, Facciorusso, Antonio, Di Matteo, Francesco, Crinò, Stefano Francesco, Pham, Khanh Do-Cong, Moon, Jong Hoo, Auriemma, Francesco, Camellini, Lorenzo, Paduano, Danilo, Stigliano, Serena, Calabrese, Federica, Ofosu, Andrew, Al-Lehibi, Abed, and Repici, Alessandro

Published
2023
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32. SLC35A2 somatic variants in drug resistant epilepsy: FCD and MOGHE

Author

Soad Elziny, Peter B. Crino, and Melodie Winawer

Subjects
Glycosylation, Somatic, Cortical malformations, Focal cortical dysplasia, Epilepsy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

De novo somatic (post-zygotic) gene mutations affecting neuroglial progenitor cell types in embryonic cerebral cortex are increasingly identified in patients with drug resistant epilepsy (DRE) associated with malformations of cortical development, in particular, focal cortical dysplasias (FCD). Somatic variants in at least 16 genes have been linked to FCD type II, all encoding components of the mechanistic target of rapamycin (mTOR) pathway. FCD type II is characterized histopathologically by cytomegalic dysmorphic neurons and balloon cells. In contrast, the molecular pathogenesis of FCD I subtypes is less well understood, and histological features are characterized by alterations in columnar or laminar organization without cytomegalic dysmorphic neurons or balloon cells. In 2018, we reported somatic mutations in Solute Carrier Family 35 member A2 (SLC35A2) linked to DRE underlying FCD type I and subsequently to a new histopathological phenotype: excess oligodendrocytes and heterotopic neurons in subcortical white matter known as MOGHE (mild malformation of cortical development with oligodendroglial hyperplasia). These discoveries opened the door to studies linking somatic mutations to FCD. In this review, we discuss the biology of SLC35A2 somatic mutations in epilepsy in FCD and MOGHE, and insights into SLC35A2 epilepsy pathogenesis, describing progress to date and critical areas for investigation.

Published
2023
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35. Semiclassical and quantum behavior of the Mixmaster model in the polymer approach for the isotropic Misner variable

Author

Crinò, Chiara, Montani, Giovanni, and Pintaudi, Giorgio

Subjects
General Relativity and Quantum Cosmology
Abstract

We analyze the semiclassical and quantum behavior of the Bianchi IX Universe in the Polymer Quantum Mechanics framework, applied to the isotropic Misner variable, linked to the space volume of the model. The study is performed both in the Hamiltonian and field equations approaches, leading to the surprising result of a still singular and chaotic cosmology, whose Poincar\'e return map asymptotically overlaps the standard Belinskii-Khalatnikov-Lifshitz one. In the quantum sector, we reproduce the original analysis due to Misner, within the revised Polymer approach and we arrive to demonstrate that the quantum numbers of the point-Universe still remain constants of motion. This issue confirms the possibility to have quasi-classical states up to the initial singularity. The present study clearly demonstrates that the asymptotic behavior of the Bianchi IX Universe towards the singularity is not significantly affected by the Polymer reformulation of the spatial volume dynamics both on a pure quantum and a semiclassical level., Comment: 25 pages, 10 figures. v2: more discussions/clarification added

Published
2018
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36. Reflecting on the YouthMappers Movement

Author

Anderson, Jennings, primary, Blevins, Chad, additional, Cowan, Nuala, additional, Carney-Nedelman, Dara, additional, Clark, Courtney, additional, Crino, Michael, additional, Engstrom, Ryan, additional, Hinton, Richard, additional, Mann, Michael, additional, McCusker, Brent, additional, Nealon, Rory, additional, Solís, Patricia, additional, and Zeballos, Marcela, additional

Published
2022
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41. Addition of Bevacizumab to Erlotinib as First-Line Treatment of Patients With EGFR-Mutated Advanced Nonsquamous NSCLC: The BEVERLY Multicenter Randomized Phase 3 Trial

Author

Piccirillo, Maria Carmela, Bonanno, Laura, Garassino, Marina Chiara, Esposito, Giovanna, Dazzi, Claudio, Cavanna, Luigi, Burgio, Marco Angelo, Rosetti, Francesco, Rizzato, Simona, Morgillo, Floriana, Cinieri, Saverio, Veccia, Antonello, Papi, Maximilan, Tonini, Giuseppe, Gebbia, Vittorio, Ricciardi, Serena, Pozzessere, Daniele, Ferro, Alessandra, Proto, Claudia, Costanzo, Raffaele, D’Arcangelo, Manolo, Proietto, Manuela, Gargiulo, Piera, Di Liello, Raimondo, Arenare, Laura, De Marinis, Filippo, Crinò, Lucio, Ciardiello, Fortunato, Normanno, Nicola, Gallo, Ciro, Perrone, Francesco, Gridelli, Cesare, and Morabito, Alessandro

Published
2022
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43. Comparative diagnostic performance of end-cutting fine-needle biopsy needles for EUS tissue sampling of solid pancreatic masses: a network meta-analysis

Author

Gkolfakis, Paraskevas, Crinò, Stefano Francesco, Tziatzios, Georgios, Ramai, Daryl, Papaefthymiou, Apostolis, Papanikolaou, Ioannis S., Triantafyllou, Konstantinos, Arvanitakis, Marianna, Lisotti, Andrea, Fusaroli, Pietro, Mangiavillano, Benedetto, Carrara, Silvia, Repici, Alessandro, Hassan, Cesare, and Facciorusso, Antonio

Published
2022
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44. Definition of a hospital volume threshold to optimize outcomes after drainage of pancreatic fluid collections with lumen-apposing metal stents: a nationwide cohort study

Author

Ramai, Daryl, Mutignani, Massimiliano, Forti, Edoardo, Arcidiacono, Paolo Giorgio, Petrone, Maria Chiara, Conte, Elisabetta, Di Mitri, Roberto, Berretti, Debora, De Nucci, Germana, Macchiarelli, Raffaele, Lovera, Mauro, Attili, Fabia, Brancaccio, Mario Luciano, Redaelli, Alessandro, Tasini, Enrico, Ballarè, Marco, Coppola, Franco, Leone, Nicola, Cugia, Luigi, Grassia, Roberto, Sbrancia, Monica, Togliani, Thomas, Lisotti, Andrea, Fusaroli, Pietro, De Angelis, Claudio, Cipolletta, Fabio, Manno, Mauro, Badas, Roberta, Pollino, Valeria, Camellini, Lorenzo, Bernardoni, Laura, Facciorusso, Antonio, Amato, Arnaldo, Crinò, Stefano Francesco, Sinagra, Emanuele, Maida, Marcello, Fugazza, Alessandro, Binda, Cecilia, Coluccio, Chiara, Repici, Alessandro, Anderloni, Andrea, Tarantino, Ilaria, and Fabbri, Carlo

Published
2022
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45. Comparison between endoscopic ultrasound-guided fine-needle biopsy and bite-on-bite jumbo biopsy for sampling of subepithelial lesions

Author

Facciorusso, Antonio, Crinò, Stefano Francesco, Ramai, Daryl, Ofosu, Andrew, Muscatiello, Nicola, Mangiavillano, Benedetto, Lamonaca, Laura, Lisotti, Andrea, Fusaroli, Pietro, Gkolfakis, Paraskevas, Stasi, Elisa, Samanta, Jayanta, Dhar, Jahnvi, Cotsoglou, Christian, Castillo, Juliana Londoño, and Antonini, Filippo

Published
2022
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46. Mouse models of Slc35a2 brain mosaicism reveal mechanisms of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy.

Author

Yoon, Hyojung, Ringland, Amanda, Anderson, James J., Sran, Sahibjot, Elziny, Soad, Huynh, Cindy, Shinagawa, Noriyuki, Badertscher, Samantha, Corrigan, Rachel R., Mashburn‐Warren, Lauren, Amari, Foued, Chen, Min, Coppola, Vincenzo, Crino, Peter B., and Bedrosian, Tracy A.

Subjects
NEURAL development, OLIGODENDROGLIA, BRAIN anatomy, GENETIC markers, KNOCKOUT mice
Abstract

Objective: Brain somatic variants in SLC35A2 were recently identified as a genetic marker for mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE). The role of SLC35A2 in cortical development and the contributions of abnormal neurons and oligodendrocytes to seizure activity in MOGHE remain largely unexplored. Methods: Here, we generated a novel Slc35a2 floxed allele, which we used to develop two Slc35a2 conditional knockout mouse lines targeting (1) the Emx1 dorsal telencephalic lineage (excitatory neurons and glia) and (2) the Olig2 lineage (oligodendrocytes). We examined brain structure, behavior, and seizure activity. Results: Knockout of Slc35a2 from the Emx1 lineage, which targets both cortical neurons and oligodendrocytes, resulted in early lethality and caused abnormal cortical development, increased oligodendroglial cell density, early onset seizures, and developmental delays akin to what is observed in patients with MOGHE. By tracing neuronal development with 5‐Ethynyl‐2'‐deoxyuridine (EdU) birthdating experiments, we found that Slc35a2 deficiency disrupts corticogenesis by delaying radial migration of neurons from the subventricular zone. To discern the contributions of oligodendrocytes to these phenotypes, we knocked out Slc35a2 from the Olig2 lineage. This recapitulated the increased oligodendroglial cell density and resulted in abnormal electroencephalographic activity, but without a clear seizure phenotype, suggesting Slc35a2 deficiency in neurons is required for epileptogenesis. Significance: This study presents two novel Slc35a2 conditional knockout mouse models and characterizes the effects on brain development, behavior, and epileptogenesis. Together, these results demonstrate a direct causal role for SLC35A2 in MOGHE‐like phenotypes, including a critical role in neuronal migration during brain development, and identify neurons as key contributors to SLC35A2‐related epileptogenesis. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Prenatal Acoustic Signals Influence Nestling Heat Shock Protein Response to Heat and Heterophil-to-Lymphocyte Ratio in a Desert Bird.

Author

Udino, Eve, Pessato, Anaïs, Addison, BriAnne, Crino, Ondi L., Buchanan, Katherine L., and Mariette, Mylene M.

Subjects
HEAT shock proteins, ZEBRA finch, CONDITIONED response, PHENOTYPIC plasticity, HIGH temperatures
Abstract

Heat shock proteins (HSPs) are essential to cellular protection against heat stress. However, the causes of inter-individual variation in HSP regulation remain unclear. This study aimed to test the impact of early-life conditions on the HSP response to heat in zebra finches. In this arid-adapted bird, incubating parents emit "heat-calls" at high temperatures, which adaptively alter offspring's phenotypes. Embryos were exposed to heat-calls or control-calls, and at 13 days post-hatch nestlings were separated into two different experiments to test responses to either chronic nest temperature ("in-nest" experiment) or an acute "heat-challenge". Blood samples were collected to measure levels of heat shock cognate 70, heat shock protein 90α, corticosterone and the heterophil-to-lymphocyte (H/L) ratio. In the in-nest experiment, both HSPs were upregulated in response to increasing nest temperatures only in control-calls nestlings (HSC70: p = 0.010, HSP90α: p = 0.050), which also had a marginally higher H/L ratio overall than heat-call birds (p = 0.066). These results point to a higher heat sensitivity in control-call nestlings. Furthermore, comparing across experiments, only the H/L ratio differed, being higher in heat-challenged than in in-nest nestlings (p = 0.009). Overall, this study shows for the first time that a prenatal acoustic signal of heat affects the nestling HSP response to postnatal temperature. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy

Author

Winawer, Melodie R, Griffin, Nicole G, Samanamud, Jorge, Baugh, Evan H, Rathakrishnan, Dinesh, Ramalingam, Senthilmurugan, Zagzag, David, Schevon, Catherine A, Dugan, Patricia, Hegde, Manu, Sheth, Sameer A, McKhann, Guy M, Doyle, Werner K, Grant, Gerald A, Porter, Brenda E, Mikati, Mohamad A, Muh, Carrie R, Malone, Colin D, Bergin, Ann Marie R, Peters, Jurriaan M, McBrian, Danielle K, Pack, Alison M, Akman, Cigdem I, LaCoursiere, Christopher M, Keever, Katherine M, Madsen, Joseph R, Yang, Edward, Lidov, Hart GW, Shain, Catherine, Allen, Andrew S, Canoll, Peter D, Crino, Peter B, Poduri, Annapurna H, and Heinzen, Erin L

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Epilepsy, Brain Disorders, Prevention, Human Genome, Neurodegenerative, Genetics, Clinical Research, Biotechnology, Aetiology, 2.1 Biological and endogenous factors, Neurological, Adolescent, Brain, Child, Drug Resistant Epilepsy, Exome, Female, Humans, Male, Malformations of Cortical Development, Monosaccharide Transport Proteins, Mutation, Neocortex, Neurons, Phosphatidylinositol 3-Kinases, TOR Serine-Threonine Kinases, Young Adult, Neurology & Neurosurgery, Clinical sciences
Abstract

ObjectiveSomatic variants are a recognized cause of epilepsy-associated focal malformations of cortical development (MCD). We hypothesized that somatic variants may underlie a wider range of focal epilepsy, including nonlesional focal epilepsy (NLFE). Through genetic analysis of brain tissue, we evaluated the role of somatic variation in focal epilepsy with and without MCD.MethodsWe identified somatic variants through high-depth exome and ultra-high-depth candidate gene sequencing of DNA from epilepsy surgery specimens and leukocytes from 18 individuals with NLFE and 38 with focal MCD.ResultsWe observed somatic variants in 5 cases in SLC35A2, a gene associated with glycosylation defects and rare X-linked epileptic encephalopathies. Nonsynonymous variants in SLC35A2 were detected in resected brain, and absent from leukocytes, in 3 of 18 individuals (17%) with NLFE, 1 female and 2 males, with variant allele frequencies (VAFs) in brain-derived DNA of 2 to 14%. Pathologic evaluation revealed focal cortical dysplasia type Ia (FCD1a) in 2 of the 3 NLFE cases. In the MCD cohort, nonsynonymous variants in SCL35A2 were detected in the brains of 2 males with intractable epilepsy, developmental delay, and magnetic resonance imaging suggesting FCD, with VAFs of 19 to 53%; Evidence for FCD was not observed in either brain tissue specimen.InterpretationWe report somatic variants in SLC35A2 as an explanation for a substantial fraction of NLFE, a largely unexplained condition, as well as focal MCD, previously shown to result from somatic mutation but until now only in PI3K-AKT-mTOR pathway genes. Collectively, our findings suggest a larger role than previously recognized for glycosylation defects in the intractable epilepsies. Ann Neurol 2018.

Published
2018

50. Safety and efficacy of a novel electrocautery-enhanced lumen-apposing metal stent in interventional EUS procedures (with video)

Author

Mangiavillano, Benedetto, Moon, Jong Ho, Crinò, Stefano Francesco, Larghi, Alberto, Pham, Khanh Do-Cong, Teoh, Anthony Yuen Bun, Paduano, Danilo, Lee, Yun Nah, Yoo, Hae Won, Shin, Il Sang, Rizzatti, Gianenrico, Robles-Medranda, Carlos, Oleas, Roberto, Conti Bellocchi, Maria Cristina, Auriemma, Francesco, Lamonaca, Laura, Spatola, Federica, Conigliaro, Rita, Facciorusso, Antonio, Gabbrielli, Armando, and Repici, Alessandro

Published
2022
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