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3 results on '"Cricelli, S"'

1. Diurnal changes in water soluble carbohydrate components in leaves and sucrose associated TaSUT1 gene expression during grain development in wheat

Author

Al-Sheikh Ahmed, S., Zhang, J., Farhan, H., Zhang, Y.J., Yu, Z., Islam, S., Chen, J., Cricelli, S., Foreman, A., Van den Ende, W., Ma, W., Dell, B., Al-Sheikh Ahmed, S., Zhang, J., Farhan, H., Zhang, Y.J., Yu, Z., Islam, S., Chen, J., Cricelli, S., Foreman, A., Van den Ende, W., Ma, W., and Dell, B.

Abstract

In plant tissues, sugar levels are determined by the balance between sugar import, export, and sugar synthesis. So far, water soluble carbohydrate (WSC) dynamics have not been investigated in a diurnal context in wheat stems as compared to the dynamics in flag leaves during the terminal phases of grain filling. Here, we filled this research gap and tested the hypothesis that WSC dynamics interlink with gene expression of TaSUT1. The main stems and flag leaves of two genotypes, Westonia and Kauz, were sampled at four hourly intervals over a 24 h period at six developmental stages from heading to 28 DAA (days after anthesis). The total levels of WSC and WSC components were measured, and TaSUT1 gene expression was quantified at 21 DAA. On average, the total WSC and fructan levels in the stems were double those in the flag leaves. In both cultivars, diurnal patterns in the total WSC and sucrose were detected in leaves across all developmental stages, but not for the fructans 6-kestose and bifurcose. However, in stems, diurnal patterns of the total WSC and fructan were only found at anthesis in Kauz. The different levels of WSC and WSC components between Westonia and Kauz are likely associated with leaf chlorophyll levels and fructan degradation, especially 6-kestose degradation. High correlation between levels of TaSUT1 expression and sucrose in leaves indicated that TaSUT1 expression is likely to be influenced by the level of sucrose in leaves, and the combination of high levels of TaSUT1 expression and sucrose in Kauz may contribute to its high grain yield under well-watered conditions.

Published
2020

2. Pharmacoeconomic consequences of amlodipine besylate therapy in patients undergoing PTCA

Author

Simona de Portu, Claudio Cricelli, Luciana Scalone, Lorenzo G. Mantovani, Enrica Menditto, Francesca Rossetti, Silvia Bustacchini, Rossetti, F, DE PORTU, S, Menditto, Enrica, Scalone, L, Bustacchini, S, Cricelli, S, and Mantovani, Lg

Subjects
Male, medicine.medical_specialty, Cost effectiveness, Cost-Benefit Analysis, medicine.medical_treatment, Population, Coronary Artery Disease, Revascularization, Coronary Restenosis, Coronary artery disease, Pharmacotherapy, Restenosis, Angioplasty, Internal medicine, medicine, Humans, Amlodipine, Angioplasty, Balloon, Coronary, education, health care economics and organizations, Randomized Controlled Trials as Topic, Pharmacology, education.field_of_study, business.industry, cost-effectiveness analysis, Middle Aged, medicine.disease, Italy, Emergency medicine, Cardiology, Female, business, medicine.drug
Abstract

In Italy, revascularization interventions increased from 44,600 in 1996 to more than 100,000 in 2001. In particular, the occurrence of percutaneous transluminal coronary angioplasty (PTCA) increased from 239 cases per million population in 1994 to about 1300 cases per million population in 2001. This trend has caused a concomitant increase in revascularization costs, which have doubled in few years, rising from Euro 421 millions in 1996 to Euro 850 millions in 2001. In 2001, PTCA amounted to 55% of total cost of revascularizations. The aim of this study was to assess the pharmacoeconomic consequences of amlodipine besylate therapy administered in patients at high risk of restenosis after PTCA. We conducted a cost-effectiveness analysis comparing therapy with amlodipine besylate added to standard care versus standard care alone. Information on clinical outcomes was drawn from the Coronary Angioplasty Amlodipine Restenosis Study (CAPARES). Medical costs were estimated with reference to drug therapy and hospitalizations for coronary events and revascularization procedures. The study was conducted from the perspective of the Italian third party payer (National Health Service). The analysis was applied to a time horizon of 4 months. Amlodipine besylate resulted less expensive and more effective than standard care. It reduced mortality, morbidity for coronary reasons and the need of revascularization procedures. The cost per 1000 patients was estimated at Euro 1,166,000 in the placebo and Euro 950,000 in the amlodipine besylate group, resulting into a cost saving of Euro 216,000, that is 18.5% of total cost of standard care. Results are sensitive to the cost of amlodipine besylate and the cost of hospitalizations, but therapy with amlodipine besylate resulted dominant even in the most unfavorable hypothesis.

Published
2006

3. Diurnal Changes in Water Soluble Carbohydrate Components in Leaves and Sucrose Associated TaSUT1 Gene Expression during Grain Development in Wheat.

Author

Al-Sheikh Ahmed S, Zhang J, Farhan H, Zhang Y, Yu Z, Islam S, Chen J, Cricelli S, Foreman A, Ende WVD, Ma W, and Dell B

Subjects
Carbohydrate Metabolism drug effects, Carbohydrates chemistry, Circadian Rhythm physiology, Dehydration genetics, Dehydration metabolism, Droughts, Edible Grain drug effects, Edible Grain genetics, Edible Grain metabolism, Gene Expression Regulation, Developmental drug effects, Gene Expression Regulation, Plant drug effects, Monosaccharide Transport Proteins metabolism, Plant Leaves drug effects, Plant Leaves genetics, Plant Proteins genetics, Plant Proteins metabolism, Seeds drug effects, Seeds genetics, Seeds growth & development, Seeds metabolism, Solubility, Water chemistry, Water pharmacology, Carbohydrate Metabolism genetics, Monosaccharide Transport Proteins genetics, Plant Leaves metabolism, Sucrose metabolism, Triticum drug effects, Triticum genetics, Triticum growth & development, Triticum metabolism
Abstract

In plant tissues, sugar levels are determined by the balance between sugar import, export, and sugar synthesis. So far, water soluble carbohydrate (WSC) dynamics have not been investigated in a diurnal context in wheat stems as compared to the dynamics in flag leaves during the terminal phases of grain filling. Here, we filled this research gap and tested the hypothesis that WSC dynamics interlink with gene expression of TaSUT1. The main stems and flag leaves of two genotypes, Westonia and Kauz, were sampled at four hourly intervals over a 24 h period at six developmental stages from heading to 28 DAA (days after anthesis). The total levels of WSC and WSC components were measured, and TaSUT1 gene expression was quantified at 21 DAA. On average, the total WSC and fructan levels in the stems were double those in the flag leaves. In both cultivars, diurnal patterns in the total WSC and sucrose were detected in leaves across all developmental stages, but not for the fructans 6-kestose and bifurcose. However, in stems, diurnal patterns of the total WSC and fructan were only found at anthesis in Kauz. The different levels of WSC and WSC components between Westonia and Kauz are likely associated with leaf chlorophyll levels and fructan degradation, especially 6-kestose degradation. High correlation between levels of TaSUT1 expression and sucrose in leaves indicated that TaSUT1 expression is likely to be influenced by the level of sucrose in leaves, and the combination of high levels of TaSUT1 expression and sucrose in Kauz may contribute to its high grain yield under well-watered conditions.

Published
2020
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