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2. Wnt/β-Catenin–Activated Nonpilomatrical Carcinoma of the Skin: A Case Series

Author

Kervarrec, Thibault, Cheok Lei, Kuan, Sohier, Pierre, Macagno, Nicolas, Jullie, Marie-Laure, Frouin, Eric, Goto, Keisuke, Taniguchi, Kohei, Hamard, Aymeric, Taillandier, Antoine, Tallet, Anne, Bonenfant, Christine, Sahin, Yusuf, Barry, Fatoumata, Taibjee, Saleem, Cokelaere, Kristof, Houben, Roland, Schrama, David, Nardin, Charline, Aubin, Francois, Doucet, Laurent, Pissaloux, Daniel, Tirode, Franck, Fouchardière, Arnaud de la, Balme, Brigitte, Laurent-Roussel, Sara, Becker, Jürgen C., von Deimling, Andreas, Samimi, Mahtab, Cribier, Bernard, Battistella, Maxime, Calonje, Eduardo, and Guyétan, Serge

Published
2024
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3. SOX10-Internal Tandem Duplications and PLAG1 or HMGA2 Fusions Segregate Eccrine-Type and Apocrine-Type Cutaneous Mixed Tumors

Author

Macagno, Nicolas, Kervarrec, Thibault, Thanguturi, Soumanth, Sohier, Pierre, Pissaloux, Daniel, Mescam, Lenaïg, Jullie, Marie-Laure, Frouin, Eric, Osio, Amelie, Faisant, Monique, Le Loarer, François, Cribier, Bernard, Calonje, Eduardo, Luna, Evelyn Vanesa Erazo, Massi, Daniela, Goto, Keisuke, Nishida, Haruto, Paindavoine, Sandrine, Houlier, Aurelie, Tantot, Juliet, Benzerdjeb, Nazim, Tirode, Franck, De la Fouchardière, Arnaud, and Battistella, Maxime

Published
2024
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4. Distinct Regulation of EZH2 and its Repressive H3K27me3 Mark in Polyomavirus-Positive and -Negative Merkel Cell Carcinoma

Author

Durand, Marie-Alice, Drouin, Aurélie, Mouchard, Alice, Durand, Laurine, Esnault, Clara, Berthon, Patricia, Tallet, Anne, Le Corre, Yannick, Hainaut-Wierzbicka, Ewa, Blom, Astrid, Saiag, Philippe, Beneton, Nathalie, Bens, Guido, Nardin, Charlee, Aubin, François, Dinulescu, Monica, Collin, Christine, Fromont-Hankard, Gaëlle, Cribier, Bernard, Laurent-Roussel, Sara, Cokelaere, Kristof, Houben, Roland, Schrama, David, Peixoto, Paul, Hervouet, Eric, Bachiri, Kamel, Kantar, Diala, Coyaud, Etienne, Guyétant, Serge, Samimi, Mahtab, Touzé, Antoine, and Kervarrec, Thibault

Published
2023
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5. Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey

Author

Kervarrec, Thibault, Tallet, Anne, Macagno, Nicolas, de la Fouchardière, Arnaud, Pissaloux, Daniel, Tirode, Franck, Bravo, Ignacio G., Nicolas, Alain, Baulande, Sylvain, Sohier, Pierre, Balme, Brigitte, Osio, Amélie, Jullie, Marie-Laure, Moulonguet, Isabelle, Bonsang, Benjamin, Tournier, Emilie, Herfs, Michael, Frouin, Eric, Zidan, Anoud, Calonje, Eduardo, Berthon, Patricia, Touzé, Antoine, Seris, Alice, Mortier, Laurent, Jouary, Thomas, Cribier, Bernard, and Battistella, Maxime

Published
2023
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6. Digital Papillary Adenocarcinoma in Nonacral Skin: Clinicopathologic and Genetic Characterization of 5 Cases

Author

Kervarrec, Thibault, Imbeaud, Sandrine, Veyer, David, Pere, Helene, Puech, Julien, Pekár-Lukacs, Agnes, Markiewicz, Dorota, Coutts, Michael, Tallet, Anne, Collin, Christine, Berthon, Patricia, Bravo, Ignacio G., Seris, Alice, Jouary, Thomas, Macagno, Nicolas, Touzé, Antoine, Cribier, Bernard, Battistella, Maxime, and Calonje, Eduardo

Published
2023
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7. Genomic profiling of a skin adnexal carcinomas cohort using a comprehensive high throughput sequencing approach

Author

Louveau, Baptiste, primary, Nakouri, Ines, additional, Jouenne, Fanélie, additional, Baroudjian, Barouyr, additional, Sadoux, Aurélie, additional, Da Meda, Laetitia, additional, Osio, Amélie, additional, Reinhart, Fanny, additional, Robert, Julien, additional, Herms, Florian, additional, Cribier, Bernard, additional, Mortier, Laurent, additional, Jouary, Thomas, additional, Basset Seguin, Nicole, additional, Lebbé, Céleste, additional, Mourah, Samia, additional, and Battistella, Maxime, additional

Published
2024
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8. Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases

Author

Kervarrec, Thibault, primary, Westphal, Danna, additional, Pissaloux, Daniel, additional, Legrand, Mélanie, additional, Tirode, Franck, additional, Neuhart, Anne, additional, Drouot, Francoise, additional, Becker, Jürgen C, additional, Macagno, Nicolas, additional, Seris, Alice, additional, Jouary, Thomas, additional, Beltzung, Fanny, additional, Jullie, Marie‐Laure, additional, Harms, Paul W, additional, Cribier, Bernard, additional, Mourah, Samia, additional, Jouenne, Fanélie, additional, Fromont, Gaelle, additional, Louveau, Baptiste, additional, Mancini, Maxence, additional, Kazakov, Dmitry V, additional, de la Fouchardière, Arnaud, additional, and Battistella, Maxime, additional

Published
2024
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11. Préfaces

Author

Cribier, Bernard, primary, Dupin, Nicolas, additional, and Beylot-Barry, Marie, additional

Published
2021
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13. Gene fusions in poroma, porocarcinoma and related adnexal skin tumours: An update.

Author

Kervarrec, Thibault, Pissaloux, Daniel, Tirode, Franck, de la Fouchardière, Arnaud, Sohier, Pierre, Frouin, Eric, Hamard, Aymeric, Houben, Roland, Schrama, David, Barlier, Anne, Cribier, Bernard, Battistella, Maxime, and Macagno, Nicolas

Subjects
YAP signaling proteins, SWEAT glands, TUMORS, DIFFERENTIAL diagnosis
Abstract

Poroma is a benign sweat gland tumour showing morphological features recapitulating the superficial portion of the eccrine sweat coil. A subset of poromas may transform into porocarcinoma, its malignant counterpart. Poroma and porocarcinoma are characterised by recurrent gene fusions involving YAP1, a transcriptional co‐activator, which is controlled by the Hippo signalling pathway. The fusion genes frequently involve MAML2 and NUTM1, which are also rearranged in other cutaneous and extracutaneous neoplasms. We aimed to review the clinical, morphological and molecular features of this category of adnexal neoplasms with a special focus upon emerging differential diagnoses, and discuss how their systematic molecular characterisation may contribute to a standardisation of diagnosis, more accurate classification and, ultimately, refinement of their prognosis and therapeutic modalities. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Gene fusions in poroma, porocarcinoma and related adnexal skin tumours: An update

Author

Kervarrec, Thibault, primary, Pissaloux, Daniel, additional, Tirode, Franck, additional, de la Fouchardière, Arnaud, additional, Sohier, Pierre, additional, Frouin, Eric, additional, Hamard, Aymeric, additional, Houben, Roland, additional, Schrama, David, additional, Barlier, Anne, additional, Cribier, Bernard, additional, Battistella, Maxime, additional, and Macagno, Nicolas, additional

Published
2023
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15. SSTR2A is a diagnostic marker of trichogerminoma

Author

Legrand, Mélanie, primary, Pissaloux, Daniel, additional, Tirode, Franck, additional, Tallet, Anne, additional, Collin, Christine, additional, Chantreau, Paul‐Louis, additional, Berthon, Patricia, additional, Jullie, Marie‐Laure, additional, Sohier, Pierre, additional, Calonje, Eduardo, additional, Luzar, Boštjan, additional, Moulonguet, Isabelle, additional, Goto, Keisuke, additional, Cokelaere, Kristof, additional, Lamant, Laurence, additional, Balme, Brigitte, additional, Deschamps, Lydia, additional, Macagno, Nicolas, additional, Cribier, Bernard, additional, Battistella, Maxime, additional, de la Fouchardière, Arnaud, additional, and Kervarrec, Thibault, additional

Published
2023
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17. Recurrent PAK2 rearrangements in poroma with folliculo‐sebaceous differentiation

Author

Kervarrec, Thibault, primary, Pissaloux, Daniel, additional, Paindavoine, Sandrine, additional, Tirode, Franck, additional, Osio, Amélie, additional, Mourah, Samia, additional, Jouenne, Fanélie, additional, Sohier, Pierre, additional, Calonje, Eduardo, additional, Pekar, Agnes, additional, Luna, Evelyn Vanesa Erazo, additional, Goto, Keisuke, additional, Delalande, Flore, additional, Frouin, Eric, additional, Macagno, Nicolas, additional, Drouot, Françoise, additional, Faisan, Monique, additional, Cribier, Bernard, additional, Battistella, Maxime, additional, and de la Fouchardière, Arnaud, additional

Published
2023
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19. Nevus Sebaceus

Author

Battistella, Maxime, Cribier, Bernard, van Krieken, J. H. J. M., Series Editor, and Massi, Daniela, editor

Published
2016
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21. Microsecretory adenocarcinoma of the skin, a novel type of sweat gland carcinoma: Report of three additional cases.

Author

Bogiatzi, Sofia, Estenaga, Angela, Louveau, Baptiste, Osio, Amélie, Deschamps, Lydia, Mourah, Samia, Poirot, Brigitte, Lehmann‐Che, Jacqueline, Cribier, Bernard, and Battistella, Maxime

Subjects
SWEAT glands, GENE fusion, CHROMOSOMAL translocation, SALIVARY glands, ADENOCARCINOMA, SYMPTOMS
Abstract

Microsecretory adenocarcinoma (MSA) is a newly described salivary gland tumor harboring a characteristic balanced chromosomal translocation resulting in MEF2C::SS18 gene fusion. Six primary cutaneous MSA cases have been recently described. We report three additional cases confirming the relevance of this recently identified entity of primary cutaneous adnexal tumor. Three patients aged 53‐, 64‐ and 78‐year‐old were retrospectively diagnosed with MSA of the skin (MSAS) as consultation cases of the CARADERM (CAncers RAres DERMatologiques) national network. The clinical presentation was an indolent nodule on the upper extremities. There was no history of salivary gland tumor. Histopathologically, the tumors presented as dermal nodular proliferation with slightly infiltrative borders, composed of cribriform and microcystic structures with abundant myxoid intraluminal secretion embedded in a fibromyxoid stroma. They diffusely expressed cytokeratin 8 and SOX10, focally p63 and heterogeneously smooth muscle actin. All tumors harbored the MEF2C::SS18 gene fusion. A complete surgical excision was performed. No local recurrence or distant metastases were observed so far (follow‐up: 17, 38, and 45 months). MSAS is the cutaneous homologue of MSA of the salivary gland, a low‐grade adnexal neoplasm whose prognosis seems to be excellent once the complete removal of the tumor is assured. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Distinct regulations driving YAP1 expression loss in poroma, porocarcinoma and RB1 ‐deficient skin carcinoma

Author

Kervarrec, Thibault, primary, Frouin, Eric, additional, Collin, Christine, additional, Tallet, Anne, additional, Tallegas, Matthias, additional, Pissaloux, Daniel, additional, Tirode, Franck, additional, Guyétant, Serge, additional, Samimi, Mahtab, additional, Gaboriaud, Pauline, additional, Touzé, Antoine, additional, Schrama, David, additional, Houben, Roland, additional, Tabareau‐Delalande, Flore, additional, Neuhart, Anne, additional, de la Fouchardière, Arnaud, additional, Osio, Amélie, additional, Cavelier–Balloy, Bénédicte, additional, Laurent‐Roussel, Sara, additional, Sohier, Pierre, additional, Cyprien, Tilmant, additional, Balme, Brigitte, additional, Belzung, Fanny, additional, Jullie, Marie‐Laure, additional, Cribier, Bernard, additional, Battistella, Maxime, additional, and Macagno, Nicolas, additional

Published
2023
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23. Prevalence of visible skin diseases: An international study of 13,138 people

Author

Cribier, Bernard, primary, Aroman, Marketa Saint, additional, Merhand, Stéphanie, additional, Aubert, Roberte, additional, Audouze, Anne, additional, Legrand, Clemence, additional, Carre, Martine, additional, Raynal, Helene, additional, Baissac, Catherine, additional, Taieb, Charles, additional, and Richard, Marie Aleth, additional

Published
2022
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27. Vismodegib efficacy in unresectable trichoblastic carcinoma: A multicenter study of 16 cases

Author

Duplaine, Alexandra, primary, Beylot-Barry, Marie, additional, Mansard, Sandrine, additional, Arnault, Jean-Philippe, additional, Grob, Jean-Jacques, additional, Maillard, Hervé, additional, Saiag, Philippe, additional, Poulalhon, Nicolas, additional, Cribier, Bernard, additional, Mortier, Laurent, additional, Battistella, Maxime, additional, and Jouary, Thomas, additional

Published
2022
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28. Superficial (nodular) thrombophlebitis as a heterogeneous entity with distinctive clinico‐pathological aspects: Correlation with the underlying conditions.

Author

Gales, Lynn, Cribier, Bernard, Lipsker, Dan, and Lenormand, Cédric

Subjects
*BEHCET'S disease, *THROMBOPHLEBITIS, *LEUKOCYTOCLASTIC vasculitis, *PUBLICATION bias
Abstract

Background: Superficial (nodular) thrombophlebitis, referring to a thrombo‐inflammatory disorder of dermal‐subcutaneous veins, encompass a spectrum of nodular lesions often associated with inflammatory, infectious, neoplastic or thrombophilic diseases. Objective: We postulate that distinct clinico‐pathological features may correlate with the underlying conditions. Methods: We conducted a retrospective monocentric study of all patients seen in our dermatology department for a superficial thrombophlebitis, completed with a literature review. Clinical and pathological data were extracted from the patient files and articles. Results: A total of 108 cases of superficial thrombophlebitis was analysed. Forty‐five percent manifested as elongated nodules clearly evoking vascular involvement, while the other 55% were presenting as nodules or plaques. The elongated phenotype was strongly associated with malignancy or thrombophilia if a pure thrombosis was demonstrated histopathologically, while tuberculosis was the main underlying condition if a granulomatous vasculitis was present. Panniculitis‐like lesions were mainly corresponding to erythema‐nodosum‐like lesions of Behçet's disease, characterized by the distinctive feature of thrombotic veins with an associated leukocytoclastic vasculitis. Limitations: Retrospective design and risk of publication bias. Conclusion: Superficial (nodular) thrombophlebitis is a heterogeneous entity with a distinct clinico‐pathological presentation that strongly points to the nature of the underlying medical condition, thus guiding the medical workup. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Recurrent FOXK1::GRHL and GPS2::GRHL fusions in trichogerminoma

Author

Kervarrec, Thibault, primary, Pissaloux, Daniel, additional, Poilane, Jeremie, additional, Tirode, Franck, additional, Tallet, Anne, additional, Collin, Christine, additional, Tallegas, Matthias, additional, Berthon, Patricia, additional, Gaboriaud, Pauline, additional, Sohier, Pierre, additional, Calonje, Eduardo, additional, Luzar, Boštjan, additional, Goto, Keisuke, additional, Cokelaere, Kristof, additional, Lamant, Laurence, additional, Balme, Brigitte, additional, Wild, Richard, additional, Neuville, Agnes, additional, Deschamps, Lydia, additional, Auberger, Elisabeth, additional, Paumier, Veronique, additional, Bonte, Helene, additional, Moulonguet, Isabelle, additional, Plantier, Françoise, additional, Cales, Valérie, additional, Pinsolle, Vincent, additional, Roblet, Denis, additional, Dupuy, Frantz, additional, Dallot, Alexiane, additional, Seris, Alice, additional, Jouary, Thomas, additional, Houben, Roland, additional, Schrama, David, additional, Hesbacher, Sonja, additional, Macagno, Nicolas, additional, Battistella, Maxime, additional, Cribier, Bernard, additional, Vergier, Beatrice, additional, de la Fouchardière, Arnaud, additional, and Jullie, Marie‐Laure, additional

Published
2022
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30. Impact of expert pathology review in skin adnexal carcinoma diagnosis: Analysis of 2573 patients from the French CARADERM network

Author

Battistella, Maxime, primary, Balme, Brigitte, additional, Jullie, Marie-Laure, additional, Zimmermann, Ute, additional, Carlotti, Agnès, additional, Crinquette, Marie, additional, Frouin, Eric, additional, Macagno, Nicolas, additional, Ortonne, Nicolas, additional, Lamant, Laurence, additional, de la Fouchardiere, Arnaud, additional, Aubriot-lorton, Marie-Hélène, additional, Durand, Luc, additional, Josselin, Nicolas, additional, Franck, Frédéric, additional, Chatelain, Denis, additional, Lemasson, Gilles, additional, Algros, Marie-Paule, additional, Durlach, Anne, additional, Machet, Marie-Christine, additional, Courville, Philippe, additional, Osio, Amélie, additional, Seris, Alice, additional, Mortier, Laurent, additional, Jouary, Thomas, additional, and Cribier, Bernard, additional

Published
2022
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35. Les transcrits de fusion FOXK1-GRHL : une signature moléculaire d’un sous-groupe de trichoblastomes caractérisés par une morphologie immature de type trichogerminomeet une hyperplasie des cellules de Merkel

Author

Kervarrec, Thibault, primary, De La Fouchardiere, Arnaud, additional, Pissaloux, Daniel, additional, Tirode, Franck, additional, Sohier, Pierre, additional, Cales, Valerie, additional, Pinsolle, Vincent, additional, Roblet, Denis, additional, Dupuis, Frantz, additional, Dallot, Alexiane, additional, Macagno, Nicolas, additional, Battistella, Maxime, additional, Cribier, Bernard, additional, Vergier, Beatrice, additional, and Jullie, Marie-Laure, additional

Published
2021
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38. Carcinomes sudoraux des extrémités : analyses moléculaires pour le diagnostic différentiel de l’adénocarcinome papillaire digital

Author

Kervarrec, Thibault, primary, Tallegas, Matthias, additional, Tallet, Anne, additional, Collin, Christine, additional, Nicolas, Alain, additional, Sohier, Pierre, additional, Baulande, Sylvain, additional, Mortier, Laurent, additional, Jouary, Thomas, additional, Macagno, Nicolas, additional, Jullie, Marie-Laure, additional, Carlotti, Agnes, additional, Cavelier-Balloy, Benedicte, additional, Seris, Alice, additional, Gaboriaud, Pauline, additional, Touze, Antoine, additional, Cribier, Bernard, additional, and Battistella, Maxime, additional

Published
2021
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44. Kalzinosen der Haut

Author

Grosshans, Edouard, Cribier, Bernard, Braun-Falco, O., editor, Petzoldt, D., editor, Schnyder, U. W., editor, Wolff, K., editor, Burg, G., editor, Christophers, E., editor, Happle, R., editor, Orfanos, C. E., editor, Plewig, G., editor, Schöpft, E., editor, Marghescu, Sandor, editor, Lubach, Dietrich, editor, and Neumann, Christine, editor

Published
1991
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46. 26271 M89, a combination of 89% Vichy volcanic mineralizing water and hyaluronic acid, is an effective adjunct to skin care in management of rosacea

Author

Berardesca, Enzo, primary, Bonfigli, Adriana, additional, Cribier, Bernard, additional, Flament, Frederic, additional, Vicic, Marco, additional, Breisse, Magali, additional, Raynaud, Emilie, additional, Durand, Ingrid, additional, Grégoire, Sebastien, additional, Kerob, Delphine, additional, and Tan, Jerry, additional

Published
2021
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48. Le rôle du Demodex dans la rosacée. La rosacée avec papulopustules :une démodécie

Author

Parmentier, Marc, De Maertelaer, Viviane, Le Moine, Alain, Cribier, Bernard, Saurat, Jean Hilaire, Kolivras, Athanassios, Richert, Bertrand, Verhoeven, Caroline, Forton, Fabienne, Parmentier, Marc, De Maertelaer, Viviane, Le Moine, Alain, Cribier, Bernard, Saurat, Jean Hilaire, Kolivras, Athanassios, Richert, Bertrand, Verhoeven, Caroline, and Forton, Fabienne

Abstract

Le Demodex, petit acarien vivant dans les follicules pilo-sébacés de tous les humains adultes, est reconnu responsable des démodécies chez l’homme mais n’est considéré dans la rosacée, au plus, que comme un facteur aggravant potentiel d’une inflammation préexistante. Toutes nos observations, depuis 1983, convergent vers la confirmation de son rôle pathogène dans la rosacée, et suggèrent des liens physiopathologiques clairs entre rosacées avec papulopustules (RPP) avec ou sans érythème permanent, rosacée érythématotélangiectasique (RET), pityriasis folliculorum et autres démodécies. (1) Dans les biopsies cutanées, le Demodex est associé à l’inflammation périfolliculaire. (2) Le concept de densité en Demodex a été introduit et une méthode de prélèvement standardisée permettant de mesurer cette densité a été développée, puis perfectionnée. (3) Elle a permis de montrer que cette densité était nettement supérieure chez les patients atteints de démodécie et de RPP, que chez ceux avec peau saine et ceux atteints d’autres dermatoses faciales, les patients avec RPP sans prolifération en Demodex étant exceptionnels. (4) Un test diagnostique hautement spécifique et sensible, utilisable facilement en consultation a été élaboré et validé. (5) Des signes cliniques discrets de ces dermatoses ont été mis en évidence, de même que la grande fréquence des démodécies en consultation de dermatologie (alors qu’elles sont très peu diagnostiquées). (6) L’effet acaricide sur le Demodex de six traitements topiques a été comparé in vivo et les meilleures molécules ont été utilisées pendant une vingtaine d’années :sur base des résultats collectés, l’efficacité du traitement a été démontrée, non seulement sur la densité en Demodex mais également sur les symptômes cliniques, tant parmi les démodécies que dans la RPP, ce qui prouve indirectement que la prolifération en parasites n’est pas un épiphénomène mais est bien la cause de la maladie. (7) Parmi les modalités comparées, les plus intenses on, Demodex folliculorum and Demodex brevis are small mites living in the pilosebaceous follicles of all adult humans. They are known to be responsible for demodicosis in humans but in rosacea are generally considered only as a potential aggravating factor of pre-existing inflammation. However, our observations since 1983 converge towards a pathogenic role of the Demodex mite in rosacea, and suggest clear pathophysiological links between rosacea with papulopustules (PPR) with or without persistent erythema, erythematotelangiectatic rosacea (ETR), pityriasis folliculorum and other demodicoses. Summarising our findings: (1) In skin biopsies, Demodex is statistically associated with perifollicular inflammation. (2) The concept of Demodex density was introduced and a method to measure it using two consecutive standardized skin surface biopsies was developed and refined. (3) It was shown that Demodex density was significantly higher in patients with demodicosis and PPR than in those with healthy skin and with other facial dermatoses; patients with PPR without Demodex proliferation detected are rare, and the few cases that do occur likely correspond to false negative results linked to proliferation of the mites deep in the pilosebaceous follicles, thus not detected by the sampling method. (4) A highly specific and sensitive diagnostic test based on the results from two consecutive standardized skin surface biopsies was developed and validated and can be easily used during clinical consultation. (5) Less well-known clinical signs of these dermatoses were highlighted, as well as the high frequency of demodicoses in dermatologic consultations (although they are under-diagnosed). (6) The acaricidal effect of six topical treatments on Demodex was compared in vivo and the best molecules were used for about 20 years in our practice. From data collected from our patients during this time period, the efficacy of the treatment was demonstrated, not only on Demodex density but also on c, Doctorat en Sciences médicales (Médecine), info:eu-repo/semantics/nonPublished

Published
2021

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