21 results on '"Cribari C"'
Search Results
2. Developing abilities in operative dentistry learning
- Author
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Luiz Carlos Machado Miguel, Lisiane Cribari C. Rangel, Edward W. Schuberet, Marcelo Thomé Schein, Luciano Madeira, and Ivo G. Zuege
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Adhesive materials ,Operative dentistry ,Ensino Odontológico. Metodologia Pedagógica. Preparo Cavitário ,Odontology Teaching. Pedagogic Methodology. Cavity Preparation ,business.industry ,medicine.medical_treatment ,Less invasive ,medicine ,Dentistry ,General Medicine ,business ,Reduction (orthopedic surgery) - Abstract
The evolution of restorative materials and the reduction in cavity preparation size are not being followed by changes in operative dentistry education. Adhesive materials and fluorine usage make cavity preparation less invasive and more conservative. This article has the purpose of showing a new teaching methodology for the early stages of operative dentistry education. Through this practice, students will be able to acquire better manual control with highspeed handpieces to avoid unnecessary eroding and to preserve dental tissue. A evolução dos materiais restauradores e a redução em tamanho dos preparos cavitários não vem sendo acompanhadas por mudanças no ensino da Dentística Restauradora. Materiais adesivos e a utilização do flúor fazem com que os preparos cavitários sejam cada vez menos invasivos e mais conservadores. Este artigo tem por objetivo propor uma nova metodologia pedagógica para o início do ensino da Dentística Restauradora. Através desta prática os alunos poderão adquirir um maior controle manual com a alta rotação evitando o desgaste desnecessário e preservando o elemento dental.
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- 2009
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3. Kidney organ injury scaling: 2025 update.
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Keihani S, Tominaga GT, Matta R, Gross JA, Cribari C, Kaups KL, Crandall M, Kozar RA, Werner NL, Zarzaur BL, Coburn M, and Myers JB
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- Humans, Acute Kidney Injury therapy, Acute Kidney Injury diagnosis, Acute Kidney Injury etiology, Conservative Treatment methods, Tomography, X-Ray Computed, Kidney injuries, Kidney diagnostic imaging
- Abstract
Abstract: The American Association for the Surgery of Trauma initially published the organ injury scaling for the kidney in 1989, which was subsequently updated in 2018. This current American Association for the Surgery of Trauma kidney organ injury scaling update incorporates the latest evidence in diagnosis and management of renal trauma and is based upon a multidisciplinary consensus. These changes reflect the near universal use of computed tomography for renal trauma evaluation and the widespread adoption of conservative management across all grades of renal trauma., (Copyright © 2025 American Association for the Surgery of Trauma.)
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- 2025
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4. More than just physician extenders: advanced practice providers (APPs) are the glue.
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Cribari C, Aksamit C, and LaGrone L
- Abstract
Competing Interests: None declared.
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- 2024
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5. Acute global testicular infarction: A rare and important complication after endovascular abdominal aortic aneurysm repair.
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Kostenko Y, LaGrone L, and Cribari C
- Abstract
Testicular ischemia is one of the most rarely reported complications of endovascular abdominal aortic aneurysm repair (EVAR). Although the pathogenesis remains unclear, thromboembolic events in the setting of testicular artery origin occlusion by the stent graft and poor baseline collateral testicular circulation are presumed causes. A 73-year-old man developed acute right testicular infarction 3 days after EVAR, requiring orchiectomy. This case emphasizes the importance of recognizing and evaluating testicular pain after EVAR and counseling patients on this possible EVAR complication., Competing Interests: None., (© 2024 The Authors.)
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- 2024
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6. American Association for the Surgery of Trauma/American College of Surgeons Committee on Trauma: Clinical protocol for damage-control resuscitation for the adult trauma patient.
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LaGrone LN, Stein D, Cribari C, Kaups K, Harris C, Miller AN, Smith B, Dutton R, Bulger E, and Napolitano LM
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- Adult, Humans, Hemorrhage etiology, Hemorrhage prevention & control, Resuscitation methods, Clinical Protocols, Blood Coagulation Disorders etiology, Blood Coagulation Disorders therapy, Hemostatics, Surgeons, Wounds and Injuries complications, Wounds and Injuries surgery
- Abstract
Abstract: Damage-control resuscitation in the care of critically injured trauma patients aims to limit blood loss and prevent and treat coagulopathy by combining early definitive hemorrhage control, hypotensive resuscitation, and early and balanced use of blood products (hemostatic resuscitation) and the use of other hemostatic agents. This clinical protocol has been developed to provide evidence-based recommendations for optimal damage-control resuscitation in the care of trauma patients with hemorrhage., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Surgery of Trauma.)
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- 2024
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7. Whole Blood Versus Conventional Blood Component Massive Transfusion Protocol Therapy in Civilian Trauma Patients.
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Lee JS, Khan AD, Wright FL, McIntyre RC Jr, Dorlac WC, Cribari C, Brockman V, Vega SA, Cofran JM, and Schroeppel TJ
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- Adult, Blood Component Transfusion, Blood Transfusion methods, Humans, Injury Severity Score, Resuscitation methods, Retrospective Studies, Young Adult, Transfusion Reaction etiology, Wounds and Injuries etiology, Wounds and Injuries therapy
- Abstract
Background: Military data demonstrating an improved survival rate with whole blood (WB) have led to a shift toward the use of WB in civilian trauma. The purpose of this study is to compare a low-titer group O WB (LTOWB) massive transfusion protocol (MTP) to conventional blood component therapy (BCT) MTP in civilian trauma patients., Methods: Trauma patients 15 years or older who had MTP activations from February 2019 to December 2020 were included. Patients with a LTOWB MTP activation were compared to BCT MTP patients from a historic cohort., Results: 299 patients were identified, 169 received LTOWB and 130 received BCT. There were no differences in age, gender, or injury type. The Injury Severity Score was higher in the BCT group (27 vs 25, P = .006). The LTOWB group had a longer transport time (33 min vs 26 min, P < .001) and a lower arrival temperature (35.8 vs 36.1, P < .001). Other hemodynamic parameters were similar between the groups. The LTOWB group had a lower in-hospital mortality rate compared to the BCT group (19.5% vs 30.0%, P = .035). There were no differences in total transfusion volumes at 4 hours and 24 hours. No differences were seen in transfusion reactions or hospital complications. Multivariable logistic regression identified ISS, age, and 24-hour transfusion volume as predictors of mortality., Discussion: Resuscitating severely injured trauma patient with LTOWB is safe and may be associated with an improved survival.
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- 2022
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8. General surgeon involvement in the care of patients designated with an American Association for the Surgery of Trauma-endorsed ICD-10-CM emergency general surgery diagnosis code in Wisconsin.
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Ingraham A, Schumacher J, Fernandes-Taylor S, Yang DY, Godat L, Smith A, Barbosa R, Cribari C, Salim A, Schroeppel T, Staudenmayer K, Crandall M, and Utter G
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- Female, Global Burden of Disease, Humans, International Classification of Diseases, Male, Middle Aged, Surgeons, Wisconsin epidemiology, Critical Care methods, Critical Care statistics & numerical data, Emergencies epidemiology, General Surgery organization & administration, Physician's Role, Surgical Procedures, Operative methods, Surgical Procedures, Operative statistics & numerical data, Wounds and Injuries diagnosis, Wounds and Injuries epidemiology, Wounds and Injuries surgery
- Abstract
Background: The current national burden of emergency general surgery (EGS) illnesses and the extent of surgeon involvement in the care of these patients remain largely unknown. To inform needs assessments, research, and education, we sought to: (1) translate previously developed International Classification of Diseases (ICD), 9th Revision, Clinical Modification (ICD-9-CM) diagnosis codes representing EGS conditions to ICD 10th Revision, CM (ICD-10-CM) codes and (2) determine the national burden of and assess surgeon involvement across EGS conditions., Methods: We converted ICD-9-CM codes to candidate ICD-10-CM codes using General Equivalence Mappings then iteratively refined the code list. We used National Inpatient Sample 2016 to 2017 data to develop a national estimate of the burden of EGS disease. To evaluate surgeon involvement, using Wisconsin Hospital Association discharge data (January 1, 2016 to June 30, 2018), we selected adult urgent/emergent encounters with an EGS condition as the principal diagnosis. Surgeon involvement was defined as a surgeon being either the attending provider or procedural physician., Results: Four hundred and eighty-five ICD-9-CM codes mapped to 1,696 ICD-10-CM codes. The final list contained 985 ICD-10-CM codes. Nationally, there were 2,977,843 adult patient encounters with an ICD-10-CM EGS diagnosis. Of 94,903 EGS patients in the Wisconsin Hospital Association data set, most encounters were inpatient as compared with observation (75,878 [80.0%] vs. 19,025 [20.0%]). There were 57,780 patients (60.9%) that underwent any procedure. Among all Wisconsin EGS patients, most had no surgeon involvement (64.9% [n = 61,616]). Of the seven most common EGS diagnoses, surgeon involvement was highest for appendicitis (96.0%) and biliary tract disease (77.1%). For the other five most common conditions (skin/soft tissue infections, gastrointestinal hemorrhage, intestinal obstruction/ileus, pancreatitis, diverticular disease), surgeons were involved in roughly 20% of patient care episodes., Conclusion: Surgeon involvement for EGS conditions ranges from highly likely (appendicitis) to relatively unlikely (skin/soft tissue infections). The wide range in surgeon involvement underscores the importance of multidisciplinary collaboration in the care of EGS patients., Level of Evidence: Prognostic/epidemiological, Level III., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2022
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9. Organ Injury Scaling 2020 update: Bowel and mesentery.
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Tominaga GT, Crandall M, Cribari C, Zarzaur BL, Bernstein M, and Kozar RA
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- Colon diagnostic imaging, Diagnosis, Differential, Humans, Intestine, Small diagnostic imaging, Mesentery diagnostic imaging, Tomography, X-Ray Computed, Wounds, Nonpenetrating diagnostic imaging, Wounds, Penetrating diagnostic imaging, Colon injuries, Intestine, Small injuries, Mesentery injuries, Trauma Severity Indices
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- 2021
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10. Avoiding Cribari gridlock 2: The standardized triage assessment tool outperforms the Cribari matrix method in 38 adult and pediatric trauma centers.
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Roden-Foreman JW, Rapier NR, Foreman ML, Cribari C, Parsons M, Zagel AL, Cull J, Coniglio RA, McGraw C, Blackmore AR, Lyell CA, Adams CA Jr, Lueckel SN, Regner JL, Holzmacher J, Sarani B, Sexton KW, Beck WC, Milia DJ, Hess JC, Workman CF, Greenwell C, Weaver M, Agrawal V, Amos JD, Nance ML, Campbell M, Dunn J, Steen S, McGonigal MD, Schroeppel TJ, Putty B, Sherar D, and Flohr SD
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- Adult, Child, Humans, Injury Severity Score, Patient Discharge, Retrospective Studies, Triage, Workload, Trauma Centers, Wounds and Injuries
- Abstract
Objectives: The Cribari Matrix Method (CMM) is the current standard to identify over/undertriage but requires manual trauma triage reviews to address its inadequacies. The Standardized Triage Assessment Tool (STAT) partially emulates triage review by combining CMM with the Need For Trauma Intervention, an indicator of major trauma. This study aimed to validate STAT in a multicenter sample., Methods: Thirty-eight adult and pediatric US trauma centers submitted data for 97,282 encounters. Mixed models estimated the effects of overtriage and undertriage versus appropriate triage on the odds of complication, odds of discharge to a continuing care facility, and differences in length of stay for both CMM and STAT. Significance was assessed at p <0.005., Results: Overtriage (53.49% vs. 30.79%) and undertriage (17.19% vs. 3.55%) rates were notably lower with STAT than with CMM. CMM and STAT had significant associations with all outcomes, with overtriages demonstrating lower injury burdens and undertriages showing higher injury burdens than appropriately triaged patients. STAT indicated significantly stronger associations with outcomes than CMM, except in odds of discharge to continuing care facility among patients who received a full trauma team activation where STAT and CMM were similar., Conclusions: This multicenter study strongly indicates STAT safely and accurately flags fewer cases for triage reviews, thereby reducing the subjectivity introduced by manual triage determinations. This may enable better refinement of activation criteria and reduced workload., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Author KWS declares that he is funded by the University of Arkansas for Medical Sciences Clinician Scientist Program. All other authors report no conflicts of interest or competing interests exist., (Copyright © 2020. Published by Elsevier Ltd.)
- Published
- 2021
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11. Reply to Letter: Organ injury scaling 2018 update: Spleen, liver, and kidney.
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Kozar RA, Crandall M, Shanmuganathan K, Zarzaur B, Coburn M, Cribari C, Kaups K, Schuster K, and Tominaga GT
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- Liver, Research Design, Kidney, Spleen
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- 2019
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12. Size matters: Computed tomographic measurements of the appendix in emergency department scans.
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Moskowitz E, Khan AD, Cribari C, and Schroeppel TJ
- Subjects
- Adult, Emergency Service, Hospital, Female, Humans, Male, Middle Aged, Organ Size, Retrospective Studies, Appendicitis diagnostic imaging, Appendix diagnostic imaging, Appendix pathology, Tomography, X-Ray Computed
- Abstract
Background: Radiologists use a size cutoff in appendiceal diameter to assist surgeons in diagnosing appendicitis, however, no consensus exists as to the size of a normal adult appendix. We aim to evaluate radial appendiceal diameter on CT in adult patients both with and without appendicitis., Methods: Retrospective review of adults who underwent abdominal CT was performed. Variables collected include: demographics, BMI, WBC count at presentation, radial diameter of appendix (mm), presence of fat stranding, fecalith, and free fluid., Results: During the study period, 3099 patients underwent CT. The appendix was visualized on 74% of scans. Mean appendiceal diameter was 6.6 mm (±1.7). The appendix was larger in patients with appendicitis (6.6 vs. 11.4; p < 0.0001). Overall appendectomy incidence was 3.2%. Sensitivity and specificity of CT in diagnosing appendicitis in this cohort of patients were 90% and 94%. NPV was 99.5%., Conclusion: While appendiceal diameter was larger in patients with appendicitis, >20% of patients without appendicitis had an appendiceal diameter >7 mm. Diameter alone should not be relied upon to diagnose appendicitis., (Copyright © 2018 Elsevier Inc. All rights reserved.)
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- 2019
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13. Organ injury scaling 2018 update: Spleen, liver, and kidney.
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Kozar RA, Crandall M, Shanmuganathan K, Zarzaur BL, Coburn M, Cribari C, Kaups K, Schuster K, and Tominaga GT
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- Humans, Kidney diagnostic imaging, Kidney pathology, Liver diagnostic imaging, Liver pathology, Spleen diagnostic imaging, Spleen pathology, Tomography, X-Ray Computed, Kidney injuries, Liver injuries, Spleen injuries, Trauma Severity Indices
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- 2018
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14. History and significance of the trauma resuscitation flow sheet.
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Dunn JA, Schroeppel TJ, Metzler M, Cribari C, Corey K, and Boyd DR
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There is little to no written information in the literature regarding the origin of the trauma flow sheet. This vital document allows programs to evaluate initial processes of trauma care. This information populates the trauma registry and is reviewed in nearly every Trauma Process Improvement and Patient Safety conference when discerning the course of patient care. It is so vital, a scribe is assigned to complete this documentation task for all trauma resuscitations, and there are continual process improvement efforts in trauma centers across the nation to ensure complete and accurate data collection. Indeed, it is the single most important document reviewed by the verification committee when evaluating processes of care at site visits. Trauma surgeons often overlook its importance during resuscitation, as recording remains the domain of the trauma scribe. Yet it is the first document scrutinized when the outcome is less than what is expected. The development of the flow sheet is not a result of any consensus statement, expert work group, or mandate, but a result of organic evolution due to the need for relevant and better data. The purpose of this review is to outline the origin, importance, and critical utility of the trauma flow sheet., Competing Interests: Competing interests: None declared.
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- 2018
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15. Thyroid Storm Induced by Trauma: A Challenging Combination.
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Davis S, McIntyre R, Cribari C, and Dunn J
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- Adrenergic beta-Antagonists therapeutic use, Antithyroid Agents therapeutic use, Female, Glucocorticoids therapeutic use, Humans, Male, Middle Aged, Neck Injuries therapy, Plasmapheresis methods, Risk Factors, Thyroid Crisis therapy, Thyroid Function Tests methods, Wounds, Nonpenetrating complications, Wounds, Nonpenetrating therapy, Neck Injuries complications, Thyroid Crisis etiology
- Published
- 2018
16. Outpatient laparoscopic appendectomy can be successfully performed for uncomplicated appendicitis: A Southwestern Surgical Congress multicenter trial.
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Frazee R, Burlew CC, Regner J, McIntyre R, Peltz E, Cribari C, Dunn J, Butler L, Reckard P, Dissanaike S, Karimi K, Behnfield C, Melo N, and Margulies D
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- Adult, Clinical Protocols, Comorbidity, Female, Humans, Male, Patient Readmission statistics & numerical data, Reoperation statistics & numerical data, Treatment Outcome, United States, Ambulatory Surgical Procedures, Appendectomy, Appendicitis surgery, Laparoscopy
- Abstract
Background: Many laparoscopic procedures are now performed on an outpatient basis. We hypothesize laparoscopic appendectomy can be safely performed as an outpatient procedure., Methods: Seven institutions adopted a previously described outpatient laparoscopic appendectomy protocol for uncomplicated appendicitis. Patients were dismissed unless there was a clinical indication for admission. Patient demographics, success with outpatient management, time of dismissal, morbidity, and readmissions were analyzed., Results: Two hundred six men and one hundred seventy women with a mean age of 35.4 years were included in the protocol. Seventy-eight patients (21%) had pre-existing comorbidities. 299 patients (80%) were managed as outpatients. There were no conversions to open appendectomy. Postoperative morbidity was 5%. The time of patient dismissals was evenly distributed throughout the day and night. Twelve patients (3%) required readmission. Outpatient follow-up occurred in 63% of patients., Conclusions: An outpatient laparoscopic appendectomy protocol was successfully applied at multiple institutions with low morbidity and low readmission rates. Application of this practice nationally could reduce length of stay and decrease overall health care costs for acute appendicitis., (Copyright © 2017. Published by Elsevier Inc.)
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- 2017
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17. Discussion of: "Outpatient laparoscopic appendectomy can be successfully performed for uncomplicated appendicitis: A Southwestern Surgical Congress multicenter trial".
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Frazee R, Burlew CC, Regner J, McIntyre R, Peltz E, Cribari C, Dunn J, Butler L, Reckard P, Dissanaike S, Karimi K, Behnfield C, Melo N, and Margulies D
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- Acute Disease, Humans, Laparoscopy, Length of Stay, Outpatients, Retrospective Studies, Treatment Outcome, Appendectomy, Appendicitis surgery
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- 2017
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18. Expanding the scope of quality measurement in surgery to include nonoperative care: Results from the American College of Surgeons National Surgical Quality Improvement Program emergency general surgery pilot.
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Wandling MW, Ko CY, Bankey PE, Cribari C, Cryer HG, Diaz JJ, Duane TM, Hameed SM, Hutter MM, Metzler MH 3rd, Regner JL, Reilly PM, Reines HD, Sperry JL, Staudenmayer KL, Utter GH, Crandall ML, Bilimoria KY, and Nathens AB
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- Appendicitis therapy, Cholecystitis therapy, Female, Humans, Intestinal Obstruction therapy, Intestine, Small, Male, Pilot Projects, Benchmarking, Emergency Medicine standards, General Surgery standards, Quality Improvement
- Abstract
Background: Patients managed nonoperatively have been excluded from risk-adjusted benchmarking programs, including the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP). Consequently, optimal performance evaluation is not possible for specialties like emergency general surgery (EGS) where nonoperative management is common. We developed a multi-institutional EGS clinical data registry within ACS NSQIP that includes patients managed nonoperatively to evaluate variability in nonoperative care across hospitals and identify gaps in performance assessment that occur when only operative cases are considered., Methods: Using ACS NSQIP infrastructure and methodology, surgical consultations for acute appendicitis, acute cholecystitis, and small bowel obstruction (SBO) were sampled at 13 hospitals that volunteered to participate in the EGS clinical data registry. Standard NSQIP variables and 16 EGS-specific variables were abstracted with 30-day follow-up. To determine the influence of complications in nonoperative patients, rates of adverse outcomes were identified, and hospitals were ranked by performance with and then without including nonoperative cases., Results: Two thousand ninety-one patients with EGS diagnoses were included, 46.6% with appendicitis, 24.3% with cholecystitis, and 29.1% with SBO. The overall rate of nonoperative management was 27.4%, 6.6% for appendicitis, 16.5% for cholecystitis, and 69.9% for SBO. Despite comprising only 27.4% of patients in the EGS pilot, nonoperative management accounted for 67.7% of deaths, 34.3% of serious morbidities, and 41.8% of hospital readmissions. After adjusting for patient characteristics and hospital diagnosis mix, addition of nonoperative management to hospital performance assessment resulted in 12 of 13 hospitals changing performance rank, with four hospitals changing by three or more positions., Conclusion: This study identifies a gap in performance evaluation when nonoperative patients are excluded from surgical quality assessment and demonstrates the feasibility of incorporating nonoperative care into existing surgical quality initiatives. Broadening the scope of hospital performance assessment to include nonoperative management creates an opportunity to improve the care of all surgical patients, not just those who have an operation., Level of Evidence: Care management, level IV; Epidemiologic, level III.
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- 2017
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19. Tranexamic Acid Use in Prehospital Uncontrolled Hemorrhage.
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Huebner BR, Dorlac WC, and Cribari C
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- Humans, Antifibrinolytic Agents pharmacology, Hemorrhage prevention & control, Tranexamic Acid pharmacology
- Abstract
The use of tranexamic acid (TXA) in the treatment of trauma patients was relatively unexplored until the landmark Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage-2 (CRASH-2) trial in 2010 demonstrated a reduction in mortality with the use of TXA. Although this trial was a randomized, double-blinded, placebo-controlled study incorporating >20,000 patients, numerous limitations and weaknesses have been described. As a result, additional studies have followed, delineating the potential risks and benefits of TXA administration. A systematic review of the literature to date reveals a mortality benefit of early (ideally <1 hour and no later than 3 hours after injury) TXA administration in the treatment of severely injured trauma patients (systolic blood pressure <90 mm Hg, heart rate >110). Combined with abundant literature showing a reduction in bleeding in elective surgery, the most significant benefit may be administration of TXA before the patient goes into shock. Those trials that failed to show a mortality benefit of TXA in the treatment of hemorrhagic shock acknowledged that most patients received blood products before TXA administration, thus confounding the results. Although the use of prehospital TXA in the severely injured trauma patient will become more clear with the trauma studies currently underway, the current literature supports the use of prehospital TXA in this high-risk population. We recommend considering a 1 g TXA bolus en route to definitive care in high-risk patients and withholding subsequent doses until hyperfibrinolysis is confirmed by thromboelastography., (Copyright © 2017 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.)
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- 2017
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20. Thoracoabdominal aortic aneurysm associated with umbilical artery catheterization: case report and review of the literature.
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Cribari C, Meadors FA, Crawford ES, Coselli JS, Safi HJ, and Svensson LG
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- Aorta, Abdominal, Aorta, Thoracic, Aortic Aneurysm diagnosis, Aortic Aneurysm therapy, Catheterization methods, Humans, Infant, Infant, Newborn, Male, Monitoring, Physiologic methods, Respiratory Distress Syndrome, Newborn physiopathology, Aortic Aneurysm etiology, Catheterization adverse effects, Umbilical Arteries
- Abstract
Aneurysms in infants and children are rare and are usually associated with cardiovascular malformations or connective tissue disorders. A new subgroup of patients has become recognized over the past two decades--those with aneurysms associated with umbilical artery catheterization. Critically ill newborns who have required umbilical artery catheterization and have developed sepsis, usually staphylococcal, are at risk for the development of mycotic aneurysm disease of the aorta or its major branches or both. Since first described in 1970, 34 cases have been reported in the literature, 14 involving the descending thoracic aorta, 10 the abdominal aorta, 6 the iliac arteries, and 4 either the thoracoabdominal aorta or multiple aneurysms involving both the thoracic and abdominal aorta. This report presents a case we recently treated of a 15-month-old-boy with a large thoracoabdominal aortic aneurysm and aneurysms of the infrarenal abdominal aorta and proximal right common iliac artery. It includes a review of the recent literature to analyze pathogenesis, clinical manifestations, and to formulate methods of treatment.
- Published
- 1992
21. Cefamandole levels during thoracoabdominal aortic aneurysm surgery.
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Harris RL, Yuk JH, Cribari C, Jernigan D, Coselli JS, Safi HJ, and Crawford ES
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- Aged, Aorta, Abdominal, Aorta, Thoracic, Cefamandole administration & dosage, Cefamandole urine, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Prospective Studies, Reproducibility of Results, Aortic Aneurysm surgery, Cefamandole blood, Premedication
- Abstract
The pharmacokinetics of prophylactic antibodies may differ in cardiac and aortic aneurysm surgery for at least two reasons: aortic aneurysm surgery generally entails a greater blood volume loss and replacement, and aortic aneurysm surgery usually does not require extracorporeal cardiopulmonary bypass. We prospectively studied two different cefamandole dosing regimens in patients undergoing aortic aneurysm surgery (phase 1, 1 gm intravenously at the induction of anesthesia; phase 2, 2 gm intravenously at the induction of anesthesia followed by 1 gm intravenously every 2 hours during surgery). In phase 1 and 2 plasma levels were measured at the time of skin incision, aortic cross-clamping, aortic unclamping, and skin closure. In phase 2 cefamandole elimination in urine and cell-saver effluent was also determined. An adequate plasma level of 10 micrograms/ml was maintained in only 4 of 14 patients in phase 1, but in 10 of 10 patients in phase 2. Cefamandole loss in cell-saver effluent was 136 +/- 100 mg, which was 13% of the measured renally excreted amount. As has been previously shown in cardiac surgery, a cefamandole prophylactic antibiotic regimen of 2 gm intravenously at the induction of anesthesia followed by 1 gm every 2 hours during surgery provides a dependable and practical dosing regimen in patients undergoing aortic aneurysm surgery.
- Published
- 1991
- Full Text
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