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1,366 results on '"Crestani, B."'

3. POS0593 CONTRIBUTION OF RARE EXONIC VARIANTS IN TELOMERE-RELATED GENES TO INTERSTITIAL LUNG DISEASE RISK IN PATIENTS WITH RHEUMATOID ARTHRITIS AND IDIOPATHIC PULMONARY FIBROSIS

Author

Juge, P. A., primary, Kawano-Dourado, L., additional, Stockwell, A., additional, Lee, J. S., additional, Gazal, S., additional, Mcdermott, G., additional, Hayashi, K., additional, Cui, J., additional, Granger, B., additional, Kannengiesser, C., additional, Borie, R., additional, Wemeau Stervinou, L., additional, Debray, M. P., additional, Wolters, P. J., additional, Marchand-Adam, S., additional, Richez, C., additional, Nunes, H., additional, Froguel, P., additional, Avouac, J., additional, Flipo, R. M., additional, Cottin, V., additional, Boissier, M. C., additional, Schaeverbeke, T., additional, Saidenberg Kermanac’h, N., additional, Crestani, B., additional, Doyle, T., additional, Raychaudhuri, S., additional, Karlson, E., additional, Yaspan, B. L., additional, and Dieudé, P., additional

Published
2024
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5. Transplantation pulmonaire en France : actualisation des indications et contre-indications en 2022

Author

Le Pavec, J., Pison, C., Hirschi, S., Bunel, V., Mordant, P., Brugière, O., Le Guen, M., Olland, A., Coiffard, B., Renaud-Picard, B., Tissot, A., Brioude, G., Borie, R., Crestani, B., Deslée, G., Stelianides, S., Mal, H., Schuller, A., Falque, L., Lorillon, G., Tazi, A., Burgel, P.R., Grenet, D., De Miranda, S., Bergeron, A., Launay, D., Cottin, V., Nunes, H., Valeyre, D., Uzunhan, Y., Prévot, G., Sitbon, O., Montani, D., Savale, L., Humbert, M., Fadel, E., Mercier, O., Mornex, J.F., Dauriat, G., and Reynaud-Gaubert, M.

Published
2022
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6. Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique – Actualisation 2021. Version intégrale

Author

Cottin, V., Bonniaud, P., Cadranel, J., Crestani, B., Jouneau, S., Marchand-Adam, S., Nunes, H., Wémeau-Stervinou, L., Bergot, E., Blanchard, E., Borie, R., Bourdin, A., Chenivesse, C., Clément, A., Gomez, E., Gondouin, A., Hirschi, S., Lebargy, F., Marquette, C.-H., Montani, D., Prévot, G., Quetant, S., Reynaud-Gaubert, M., Salaun, M., Sanchez, O., Trumbic, B., Berkani, K., Brillet, P.-Y., Campana, M., Chalabreysse, L., Chatté, G., Debieuvre, D., Ferretti, G., Fourrier, J.-M., Just, N., Kambouchner, M., Legrand, B., Le Guillou, F., Lhuillier, J.-P., Mehdaoui, A., Naccache, J.-M., Paganon, C., Rémy-Jardin, M., Si-Mohamed, S., and Terrioux, P.

Published
2022
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9. Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique – Actualisation 2021. Version courte

Author

Cottin, V., Bonniaud, P., Cadranel, J., Crestani, B., Jouneau, S., Marchand-Adam, S., Nunes, H., Wémeau-Stervinou, L., Bergot, E., Blanchard, E., Borie, R., Bourdin, A., Chenivesse, C., Clément, A., Gomez, E., Gondouin, A., Hirschi, S., Lebargy, F., Marquette, C.-H., Montani, D., Prévot, G., Quetant, S., Reynaud-Gaubert, M., Salaun, M., Sanchez, O., Trumbic, B., Berkani, K., Brillet, P.-Y., Campana, M., Chalabreysse, L., Chatté, G., Debieuvre, D., Ferretti, G., Fourrier, J.-M., Just, N., Kambouchner, M., Legrand, B., Le Guillou, F., Lhuillier, J.-P., Mehdaoui, A., Naccache, J.-M., Paganon, C., Rémy-Jardin, M., Si-Mohamed, S., and Terrioux, P.

Published
2022
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12. L’exposition au long cours à la pollution atmosphérique est associée au risque de développer une pneumopathie interstitielle diffuse chez les patients ayant une polyarthrite rhumatoïde

Author

Sesé, L., primary, Annesi-Maesano, I., additional, Juge, P.A., additional, Mayer, S., additional, Sigaux, J., additional, Crestani, B., additional, Semerano, L., additional, Dessimond, B., additional, Borie, R., additional, Debray, M.P., additional, Combe, B., additional, Constantin, A., additional, Didier, M., additional, Brillet, P.Y., additional, Uzunhan, Y., additional, Dieudé, P., additional, and Nunes, H., additional

Published
2024
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13. Quels changements de comportements vis-à-vis des expositions chez les apparentés au premier degré des patients ayant une fibrose pulmonaire familiale associée à une mutation du complexe télomérase

Author

Sesé, L., primary, Bouvry, D., additional, Kannengiesser, C., additional, Khamis, W., additional, Vagnarelli, S., additional, Guérin, C., additional, Lassus, A., additional, Crestani, B., additional, Gueguen, S., additional, Nunes, H., additional, and Borie, R., additional

Published
2024
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14. Cohorte RADICO-ILD2 (Projet FIFA) : atteintes asymptomatiques chez les apparentés de porteurs de variants de gènes liés aux télomères

Author

Guerin, C., primary, Kannengiesser, C., additional, Bramki, K., additional, Jouneau, S., additional, Prevot, G., additional, Marchand-Adam, S., additional, Dominique, S., additional, Andréjak, C., additional, Wemeau, L., additional, Crestani, B., additional, Lainey, E., additional, Sicre De Fontbrune, F., additional, Plessier, A., additional, Dubus, J.C., additional, Clement, A., additional, Nunes, H., additional, Valeyre, D., additional, Nathan, N., additional, Cadranel, J., additional, Israel Biet, D., additional, Reynaud-Gaubert, M., additional, Bonniaud, P., additional, Dufaure-Gare, I., additional, Plouvier, L., additional, Nasri, I., additional, Lassus, A., additional, Ba, I., additional, Cottin, V., additional, Gueguen, S., additional, and Borie, R., additional

Published
2024
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15. Identification d’un sous-groupe de patients présentant une fibrose pulmonaire progressive au cours de la pneumopathie interstitielle associée au syndrome de Gougerot-Sjögren

Author

Diou, C., primary, Debray, M.P., additional, Porcher, R., additional, Bancal, C., additional, Sacré, K., additional, Taillé, C., additional, Khamis, W., additional, Dhote, R., additional, Borie, R., additional, Nunes, H., additional, Uzunhan, Y., additional, and Crestani, B., additional

Published
2024
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16. Rituximab et Mycophénolate Mofétil dans les pneumopathies interstitielles diffuses (EVER-ILD) : résultats à 1 an d’un essai randomisé contrôlé

Author

Mansy, L., primary, Caille, A., additional, Reynaud-Gaubert, M., additional, Bonniaud, P., additional, Borie, R., additional, Cadranel, J., additional, Court-Fortune, I., additional, Crestani, B., additional, Gomez, E., additional, Gondouin, A., additional, Hirschi-Santelmo, S., additional, Israel-Biet, D., additional, Jouneau, S., additional, Marquette, C.H., additional, Naccache, J.M., additional, Nunes, H., additional, Plantier, L., additional, Prevot, G., additional, Quetant, S., additional, Traclet, J., additional, Wémeau-Stervinou, L., additional, Cottin, V., additional, and Marchand-Adam, S., additional

Published
2024
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17. Isoniazid-monoresistant tuberculosis in France: Risk factors, treatment outcomes and adverse events

Author

Bouchaud, O., Billard-Pomares, T., Carbonnelle, E., Mechaï, F., Nunes, H., Pellan, M., Morin, A.-S., Dumesnil, C., Dumoulin, J., Roux, A.-L., Jachym, M., le Du, D., Marigot-Outtandy, D., Abgrall, S., Chambrin, V., Guillet, C., Fantin, B., Galy, A., Decousser, J.-W., Lelièvre, J.D., Gallien, S., Nebbad-Lechani, B., Deconinck, L., Bulifon, S., Fortineau, N., Wyplosz, B., Cohen, F., Lemaitre, N., Crestani, B., Grall, N., Pierre-Audigier, C., Rioux, C., Yazdanpanah, Y., Le Jeunne, C., Morand, P., Roche, N., Pavie, J., Loulergue, P., Delcey, V., Lecorché, E., Munier, A.-L., Mougari, F., Sellier, P., Bille, E., Ferroni, A., Guéry, R., Hummel, A., Lourenco, J., Aubry, A., Bonnet, I., Caumes, E., Londner, C., Morel, F., Lacombe, K., Lalande, V., Meynard, J.-L., Veziris, N., De Castro, N., Denis, B., Lafaurie, M., Molina, J.-M., Canestri, A., Lassel, L., Pialoux, G., Verdet, C., Nardi, A.-L., Gominet, M., Catherinot, E., Bachir, Marwa, Guglielmetti, Lorenzo, Tunesi, Simone, Billard-Pomares, Typhaine, Chiesi, Sheila, Jaffré, Jérémy, Langris, Hugo, Pourcher, Valérie, Schramm, Frédéric, Lemaître, Nadine, and Robert, Jérôme

Published
2021
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23. Nintedanib in patients with progressive fibrosing interstitial lung diseases—subgroup analyses by interstitial lung disease diagnosis in the INBUILD trial: a randomised, double-blind, placebo-controlled, parallel-group trial

Author

Abe, S., Aburto, M., Acosta, O., Andrews, C., Antin-Ozerkis, D., Arce, G., Arias, M., Avdeev, S., Barczyk, A., Bascom, R., Bazdyrev, E., Beirne, P., Belloli, E., Bergna, M.A., Bergot, E., Bhatt, N., Blaas, S., Bondue, B., Bonella, F., Britt, E., Buch, K., Burk, J., Cai, H., Cantin, A., Castillo Villegas, D.M., Cazaux, A., Cerri, S., Chaaban, S., Chaudhuri, N., Cottin, V., Crestani, B., Criner, G., Dahlqvist, C., Danoff, S., Dematte D'Amico, J., Dilling, D., Elias, P., Ettinger, N., Falk, J., Fernández Pérez, E.R., Gamez-Dubuis, A., Giessel, G., Gifford, A., Glassberg, M., Glazer, C., Golden, J., Gómez Carrera, L., Guiot, J., Hallowell, R., Hayashi, H., Hetzel, J., Hirani, N., Homik, L., Hope-Gill, B., Hotchkin, D., Ichikado, K., Ilkovich, M., Inoue, Y., Izumi, S., Jassem, E., Jones, L., Jouneau, S., Kaner, R., Kang, J., Kawamura, T., Kessler, R., Kim, Y., Kishi, K., Kitamura, H., Kolb, M., Kondoh, Y., Kono, C., Koschel, D., Kreuter, M., Kulkarni, T., Kus, J., Lebargy, F., León Jiménez, A., Luo, Q., Mageto, Y., Maher, T.M., Makino, S., Marchand-Adam, S., Marquette, C., Martinez, R., Martínez, M., Maturana Rozas, R., Miyazaki, Y., Moiseev, S., Molina-Molina, M., Morrison, L., Morrow, L., Moua, T., Nambiar, A., Nishioka, Y., Nunes, H., Okamoto, M., Oldham, J., Otaola, M., Padilla, M., Park, J.S., Patel, N., Pesci, A., Piotrowski, W., Pitts, L., Poonyagariyagorn, H., Prasse, A., Quadrelli, S., Randerath, W., Refini, R., Reynaud-Gaubert, M., Riviere, F., Rodríguez Portal, J.A., Rosas, I., Rossman, M., Safdar, Z., Saito, T., Sakamoto, N., Salinas Fénero, M., Sauleda, J., Schmidt, S., Scholand, M.B., Schwartz, M., Shapera, S., Shlobin, O., Sigal, B., Silva Orellana, A., Skowasch, D., Song, J.W., Stieglitz, S., Stone, H., Strek, M., Suda, T., Sugiura, H., Takahashi, H., Takaya, H., Takeuchi, T., Thavarajah, K., Tolle, L., Tomassetti, S., Tomii, K., Valenzuela, C., Vancheri, C., Varone, F., Veeraraghavan, S., Villar, A., Weigt, S., Wemeau, L., Wuyts, W., Xu, Z., Yakusevich, V., Yamada, Y., Yamauchi, H., Ziora, D., Wells, Athol U, Flaherty, Kevin R, Brown, Kevin K, Inoue, Yoshikazu, Devaraj, Anand, Richeldi, Luca, Moua, Teng, Crestani, Bruno, Wuyts, Wim A, Stowasser, Susanne, Quaresma, Manuel, Goeldner, Rainer-Georg, Schlenker-Herceg, Rozsa, and Kolb, Martin

Published
2020
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25. Déchiffrer la pneumopathie interstitielle diffuse associée à la polyarthrite rhumatoïde en utilisant une analyse en cluster hiérarchique non supervisée : résultats d’une collaboration internationale

Author

Juge, P.A., primary, Granger, B., additional, El Houari, L., additional, Mcdermott, G., additional, Doyle, T., additional, Kelly, C., additional, Gouri, K., additional, Vassallo, R., additional, Alarcon Calderon, A., additional, Kalyoncu, U., additional, Gonzales, A., additional, Mena-Vazquez, N., additional, Rojas-Gimenez, M., additional, Dos Santos-Sobrin, R., additional, Retuerto-Guerrero, M., additional, Vadillo-Font, C., additional, Vela, P., additional, Fernandez-Nebro, A., additional, Escudero-Contreras, A., additional, Pérez-Pampin, E., additional, Pablos-Alvarez, J.L., additional, Abasolo, L., additional, Hyldgaard, C., additional, Froidure, A., additional, Durez, P., additional, Rojas-Serrano, J., additional, Van Moorsel, C., additional, Grutters, J., additional, Kawano, L., additional, Lucas, C., additional, Jouneau, S., additional, Sanmartí, R., additional, Castellanos Moreira, R., additional, Antoniou, K., additional, Molina Molina, M., additional, Solomon, J., additional, Raia, S., additional, González-Gay, M.A., additional, Atienza-Mateo, B., additional, Flouda, S., additional, Effrosyni, M., additional, Boumpas, D., additional, Papiris, S., additional, Karageorgas, T., additional, Sebastiani, M., additional, Manfredi, A., additional, Duarte, A.C., additional, Crestani, B., additional, Sparks, J., additional, and Dieudé, P., additional

Published
2023
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26. Variants exoniques rares et délétères au sein des gènes associés aux téloméropathies et risque de pneumopathies interstitielles diffuses associées à la polyarthrite rhumatoïde

Author

Juge, P.A., primary, Kawano, L., additional, Gazal, S., additional, Mcdermott, G., additional, Hayashi, K., additional, Cui, J., additional, Debray, M.P., additional, Wemeau-Stervinou, L., additional, Marchand-Adam, S., additional, Richez, C., additional, Nunes, H., additional, Avouac, J., additional, Saidenberg-Kermanac’h, N., additional, Kannengiesser, C., additional, Borie, R., additional, Crestani, B., additional, Doyle, T., additional, Raychaudhuri, S., additional, Sparks, J., additional, and Dieudé, P., additional

Published
2023
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28. Clinical standards for diagnosis, treatment and prevention of post-COVID-19 lung disease

Author

Visca, D., primary, Centis, R., additional, Pontali, E., additional, Zampogna, E., additional, Russell, A.-M., additional, Migliori, G. B., additional, Andrejak, C., additional, Aro, M., additional, Bayram, H., additional, Berkani, K., additional, Bruchfeld, J., additional, Chakaya, J. M., additional, Chorostowska-Wynimko, J., additional, Crestani, B., additional, Dalcolmo, M. P., additional, D’Ambrosio, L., additional, Dinh-Xuan, A-T., additional, Duong-Quy, S., additional, Fernandes, C., additional, García-García, J.-M., additional, de Melo Kawassaki, A, additional, Carrozzi, L., additional, Martinez-Garcia, M. A., additional, Martins, P. Carreiro, additional, Mirsaeidi, M., additional, Mohammad, Y., additional, Naidoo, R. N., additional, Neuparth, N., additional, Sese, L., additional, Silva, D. R., additional, Solovic, I., additional, Sooronbaev, T. M., additional, Spanevello, A., additional, Sverzellati, N., additional, Tanno, L., additional, Tiberi, S., additional, Vasankari, T., additional, Vasarmidi, E., additional, Vitacca, M., additional, and Annesi-Maesano, I., additional

Published
2023
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30. Clinical and economic burden of severe asthma: A French cohort study

Author

Aubier, M., Crestani, B., Taillé, C., Dombret, M.C., Pretolani, M., Berger, P., Bourdin, A., Vachier, I., Molinari, N., Chanez, P., Similowski, T., Didier, A., De Blay, F., Humbert, M., Garcia, G., Magnan, A., Maitre, B., Roche, N., Tsicopoulos, A., Chenivesse, C., Deslée, G., Marquette, C.H., Devouassoux, G., Nordon, Clementine, Grimaldi-Bensouda, Lamiae, Pribil, Celine, Nachbaur, Gaelle, Amzal, Billy, Thabut, Gabriel, Marthan, Roger, and Aubier, Michel

Published
2018
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32. French practical guidelines for the diagnosis and management of idiopathic pulmonary fibrosis – 2017 update. Full-length version

Author

Cottin, V., Crestani, B., Cadranel, J., Cordier, J.-F., Marchand-Adam, S., Prévot, G., Wallaert, B., Bergot, E., Camus, P., Dalphin, J.-C., Dromer, C., Gomez, E., Israel-Biet, D., Jouneau, S., Kessler, R., Marquette, C.-H., Reynaud-Gaubert, M., Aguilaniu, B., Bonnet, D., Carré, P., Danel, C., Faivre, J.-B., Ferretti, G., Just, N., Lebargy, F., Philippe, B., Terrioux, P., Thivolet-Béjui, F., Trumbic, B., and Valeyre, D.

Published
2017
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33. French practical guidelines for the diagnosis and management of idiopathic pulmonary fibrosis – 2017 update. Short-length version

Author

Cottin, V., Crestani, B., Cadranel, J., Cordier, J.-F., Marchand-Adam, S., Prévot, G., Wallaert, B., Bergot, E., Camus, P., Dalphin, J.-C., Dromer, C., Gomez, E., Israel-Biet, D., Jouneau, S., Kessler, R., Marquette, C.-H., Reynaud-Gaubert, M., Aguilaniu, B., Bonnet, D., Carré, P., Danel, C., Faivre, J.-B., Ferretti, G., Just, N., Lebargy, F., Philippe, B., Terrioux, P., Thivolet-Béjui, F., Trumbic, B., and Valeyre, D.

Published
2017
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34. Clinical Features and Outcomes of Patients With Myositis Associated-Interstitial Lung Disease

Author

Karampitsakos, T., primary, Tzilas, V., additional, Papaioannou, O., additional, Chrysikos, S., additional, Vasarmidi, E., additional, Juge, P.-A., additional, Vizirianaki, S., additional, Bibaki, E., additional, Reppa, A., additional, Sidiropoulos, P., additional, Katsaras, M., additional, Sotiropoulou, V., additional, Tsiri, P., additional, Koulousousa, E., additional, Theochari, E., additional, Tsirikos, G., additional, Christopoulos, I., additional, Malakounidou, E., additional, Zarkadi, E., additional, Sampsonas, F., additional, Hillas, G., additional, Karageorgas, T., additional, Daoussis, D., additional, Kalogeropoulou, C., additional, Dimakou, K., additional, Tzanakis, N., additional, Borie, R., additional, Dieudé, P., additional, Antoniou, K., additional, Crestani, B., additional, Bouros, D., additional, and Tzouvelekis, A., additional

Published
2023
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37. Ziritaxestat, a novel autotaxin inhibitor, and lung function in idiopathic pulmonary fibrosis

Author

Maher, TM, Ford, P, Brown, KK, Costabel, U, Cottin, V, Danoff, SK, Groenveld, I, Helmer, E, Jenkins, RG, Milner, J, Molenberghs, G, Penninckx, B, Randall, MJ, Van Den Blink, B, Fieuw, A, Vandenrijn, C, Rocak, S, Seghers, I, Shao, L, Taneja, A, Jentsch, G, Watkins, TR, Wuyts, WA, Kreuter, M, Verbruggen, N, Prasad, N, Wijsenbeek, MS, Chambers, D, Chia, M, Corte, T, Glaspole, I, Goh, N, Holmes, M, Malouf, M, Thien, F, Veitch, E, Bondue, B, Dahlqvist, C, Froidure, A, Slabbynck, H, Wuyts, W, Cartagena Salinas, C, Feijoó Seoane, R, Martínez, V, Maturana, R, Pavie Gallegos, J, Rosenblut, A, Silva, R, Undurraga Pereira, A, Doubkova, M, Pauk, N, Plackova, M, Sterclova, M, Bendstrup, E, Shaker, SB, Titlestad, I, Budweiser, S, Grohé, C, Koschel, D, Prasse, A, Weber, M, Wirtz, H, Antoniou, K, Daniil, Z, Gaga, M, Papakosta, D, Izumi, S, Okamoto, M, Guerreros Benavides, A, Iberico Barrera, C, Peña Villalobos, AM, Campo Ezquibela, A, Cifrian Martinez, JM, Fernandez Fabrellas, E, Leiro, V, Molina-Molina, M, Nieto Barbero, A, Sellares Torres, J, Valenzuela, C, Cheng, S-L, Kuo, P-H, Lee, K-Y, Sheu, C-C, Gunen, H, Mogulkoc Bishop, N, Nayci, S, Adamali, H, Bianchi, S, Chaudhuri, N, Gibbons, M, Hart, S, Molyneaux, P, Parfrey, H, Saini, G, Spencer, LG, Wiscombe, S, Antin-Ozerkis, D, Bascom, R, Belperio, J, Britt, E, Fitzgerald, J, Gomez Manjarres, D, Gotfried, M, Gupta, N, Hotchkin, D, Kaye, M, Kreider, M, Kureishy, S, Lacamera, P, Lancaster, L, Lasky, J, Lorch, D, Mannem, H, Morrow, L, Moua, T, Nambiar, A, Raghu, G, Raj, R, Ramaswamy, M, Reddy, R, Russell, T, Scholand, MB, Shea, B, Suliman, S, Swigris, J, Thavarajah, K, Tolle, L, Tomic, R, Warshoff, N, Wesselius, L, Yung, G, Bergna, M, De Salvo, M, Fernandez Acquier, M, Rodriguez, A, Saez Scherbovsky, P, Assayag, D, Dhar, A, Khalil, N, Morisset, J, Provencher, S, Ryerson, C, Shapera, S, Bourdin, A, Crestani, B, Lebargy, F, Reynaud-Gaubert, M, Bonella, FT, Claussen, M, Hammerl, P, Karagiannidis, C, Keller, C, Randerath, W, Stubbe, B, Csánky, E, Medgyasszay, B, Muller, V, Adir, Y, Bar-Shai, A, Berkman, N, Fink, G, Kramer, M, Shitrit, D, Bargagli, E, Gasparini, S, Harari, S, Ravaglia, C, Richeldi, L, Vancheri, C, Ebina, M, Fujita, M, Ichikado, K, Inoue, Y, Ishikawa, N, Kato, M, Kawamura, T, Kondoh, Y, Nishioka, Y, Ogura, T, Owan, I, Saito, T, Sakamoto, N, Sakamoto, K, Shirai, M, Suda, T, Tomii, K, Chung, MP, Jeong, SH, Park, CS, Park, JS, Song, JW, Uh, S-T, Chavarria Martinez, U, Montano Gonzalez, E, Ramirez, A, Selman Lama, ME, Bresser, P, Kramer, H, Mostard, R, Nossent, E, Veltkamp, M, Wijsenbeek, M, Beckert, L, Chang, CL, Veale, A, Wilsher, M, Bednarek, M, Gasior, G, Jasieniak-Pinis, G, Jassem, E, Mroz, R, Piotrowski, W, Abdullah, I, Ambaram, A, Irusen, E, Van der Linden, M, Van Zyl-Smit, R, Williams, P, Allen, J, Averill, F, Belloli, E, Brown, A, Case, A, Chaudhary, S, Criner, G, DeBoer, K, Dilling, D, Dorf, J, Enelow, R, Ettinger, N, Feldman, J, Gibson, K, Golden, J, Hamblin, M, Hunninghake, G, Karunakara, R, Kim, H, Luckhardt, T, Menon, P, Morrison, L, Oldham, J, Patel, N, Schmidt, S, Strek, M, Summer, R, Sussman, R, Tita, J, Veeraraghavan, S, Whelan, T, and Zibrak, J

Abstract

Importance There is a major need for effective, well-tolerated treatments for idiopathic pulmonary fibrosis (IPF). Objective To assess the efficacy and safety of the autotaxin inhibitor ziritaxestat in patients with IPF. Design, Setting, and Participants The 2 identically designed, phase 3, randomized clinical trials, ISABELA 1 and ISABELA 2, were conducted in Africa, Asia-Pacific region, Europe, Latin America, the Middle East, and North America (26 countries). A total of 1306 patients with IPF were randomized (525 patients at 106 sites in ISABELA 1 and 781 patients at 121 sites in ISABELA 2). Enrollment began in November 2018 in both trials and follow-up was completed early due to study termination on April 12, 2021, for ISABELA 1 and on March 30, 2021, for ISABELA 2. Interventions Patients were randomized 1:1:1 to receive 600 mg of oral ziritaxestat, 200 mg of ziritaxestat, or placebo once daily in addition to local standard of care (pirfenidone, nintedanib, or neither) for at least 52 weeks. Main Outcomes and Measures The primary outcome was the annual rate of decline for forced vital capacity (FVC) at week 52. The key secondary outcomes were disease progression, time to first respiratory-related hospitalization, and change from baseline in St George’s Respiratory Questionnaire total score (range, 0 to 100; higher scores indicate poorer health-related quality of life). Results At the time of study termination, 525 patients were randomized in ISABELA 1 and 781 patients in ISABELA 2 (mean age: 70.0 [SD, 7.2] years in ISABELA 1 and 69.8 [SD, 7.1] years in ISABELA 2; male: 82.4% and 81.2%, respectively). The trials were terminated early after an independent data and safety monitoring committee concluded that the benefit to risk profile of ziritaxestat no longer supported their continuation. Ziritaxestat did not improve the annual rate of FVC decline vs placebo in either study. In ISABELA 1, the least-squares mean annual rate of FVC decline was –124.6 mL (95% CI, −178.0 to −71.2 mL) with 600 mg of ziritaxestat vs –147.3 mL (95% CI, −199.8 to −94.7 mL) with placebo (between-group difference, 22.7 mL [95% CI, −52.3 to 97.6 mL]), and –173.9 mL (95% CI, −225.7 to −122.2 mL) with 200 mg of ziritaxestat (between-group difference vs placebo, −26.7 mL [95% CI, −100.5 to 47.1 mL]). In ISABELA 2, the least-squares mean annual rate of FVC decline was –173.8 mL (95% CI, −209.2 to −138.4 mL) with 600 mg of ziritaxestat vs –176.6 mL (95% CI, −211.4 to −141.8 mL) with placebo (between-group difference, 2.8 mL [95% CI, −46.9 to 52.4 mL]) and –174.9 mL (95% CI, −209.5 to −140.2 mL) with 200 mg of ziritaxestat (between-group difference vs placebo, 1.7 mL [95% CI, −47.4 to 50.8 mL]). There was no benefit with ziritaxestat vs placebo for the key secondary outcomes. In ISABELA 1, all-cause mortality was 8.0% with 600 mg of ziritaxestat, 4.6% with 200 mg of ziritaxestat, and 6.3% with placebo; in ISABELA 2, it was 9.3% with 600 mg of ziritaxestat, 8.5% with 200 mg of ziritaxestat, and 4.7% with placebo. Conclusions and Relevance Ziritaxestat did not improve clinical outcomes compared with placebo in patients with IPF receiving standard of care treatment with pirfenidone or nintedanib or in those not receiving standard of care treatment. Trial Registration ClinicalTrials.gov Identifiers: NCT03711162 and NCT03733444

Published
2023

42. Effet protecteur du FGF21 endogène et exogène dans la fibrose pulmonaire

Author

Ghanem, M., primary, Archer, G., additional, Justet, A., additional, Hachem, M., additional, Boghanim, T., additional, Vadel, A., additional, Poté, N., additional, Cazes, A., additional, Mordant, P., additional, Castier, Y., additional, Mal, H., additional, Jaillet, M., additional, Mailleux, A., additional, and Crestani, B., additional

Published
2023
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45. Prévalence du cancer du poumon dans une cohorte de patients porteurs d’une mutation d’un gène lié au surfactant

Author

Brudon, A., primary, Legendre, M., additional, Mageau, A., additional, Nathan, N., additional, Bermudez, J., additional, Bouvry, D., additional, Cadranel, J., additional, Cazes, A., additional, Crestani, B., additional, Dégot, T., additional, Delestrain, C., additional, Diesler, R., additional, Epaud, R., additional, Debray, M.P., additional, Fanen, P., additional, Gaubert, A., additional, Manali, E., additional, Gondouin, A., additional, Guillaumot, A., additional, Hirschi, S., additional, Leroy, S., additional, Marchand-Adam, S., additional, Nunes, H., additional, Amselem, S., additional, Picard, C., additional, Prevot, G., additional, Reynaud, M., additional, De Vuyst, P., additional, Wémeau-Stervinou, L., additional, Zalcman, G., additional, Cottin, V., additional, and Borie, R., additional

Published
2023
Full Text
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48. Effet protecteur du FGF21 dans la fibrose pulmonaire

Author

Ghanem, M., primary, Archer, G., additional, Justet, A., additional, Hachem, M., additional, Boghanim, T., additional, Vadel, A., additional, Poté, N., additional, Cazes, A., additional, Mordant, P., additional, Castier., Y., additional, Mal, H., additional, Jaillet, M., additional, Mailleux, A., additional, and Crestani, B., additional

Published
2023
Full Text
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