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3. Abstracts

Author

Kaatsch, Hans-Jürgen, Püschel, K., Heinemann, A., Klaas, Jakob, Graß, Hildegard, Staak, Michael, Benthaus, S., Vock, R., Brinkmann, B., Temme, O., Daldrup, T., Dilger, M., Fink, T., Rittner, Ch., Thali, Michael J., Braun, M., Brueschweiler, W., Kneubuehl, B. P., Vock, P., Wirth, J., Dirnhofer, R., Bohnert, M., Berger, H., Buck, U., Pollak, S., Gotta, J. C., Erdmann, F., Riße, M., Schütz, H., Weiler, G., Pragst, F., Auwärter, V., Sporkcrt, F., Roewer, L., Willuweit, S., Kayser, M., Nagy, M., de Knijff, P., Geserick, G., Augustin, C., Betz, A., Carracedo, A., Corach, D., Dupuy, B. M., Gusmaõ, L., Henke, L., Hidding, M., Kärgel, H. J., Lessig, R., Liebeherr, E., Parson, W., Pascali, V. L., Rolf, B., Schneider, P. M., Dobosz, T., Teifel-Greding, J., Krawczak, M., Bauer, M., Patzelt, D., Kuznik, J., Bondy, B., Eisenmenger, W., Möller, H. -J., Zehner, R., Niess, C., Amendt, J., Krettek, R., Weinmann, W., Görner, M., Goerke, R., Mahler, H., Fowinkel, C., Haarhoff, K., Schmidt, P., Schmolke, C., Mußhoff, F., Menzen, M., Prohaska, C., Madea, B., Kauert, G., Gleicher, S., Drasch, G., von Meyer, L., Roider, G., Quitterer, D., Kröner, L., Toennes, S. W., Jurowich, S., Käferstein, H., Sticht, G., Gilg, T., Priemer, F., Jocham, N., Fechner, G., Ortmann, Ch., Schulte, T., Nieschalk, M., Weirich, V., Rummel, J., Rentsch, D., Wegener, R., Berehaus, G., Graß, H., Grellner, W., Rettig-Stürmer, A., Kühn-Becker, H., Georg, T., Möller, M., Wilske, J., Kemmerling, R., Sachs, H., Menting, T., Musshoff, F., Schoenemeier, S., Bürrig, K. -F., Jacob, B., Bonte, W., Maeda, H., Zhu, B. -L., Fujita, M. Q., Quan, L., Ishida, K., Taniguchi, M., Böhme, B., Rauch, E., Penning, R., Amberg, R., Blackwell, C. C., Pelz, K., Meier, V., Saternus, K. -S., Gessler, F., Böhnel, H., Bouska, I., Toupalík, P., Klir, P., Kleemann, W. J., Ast, F., Beck, U., Debertin, S., Giebe, B., Heide, S., Sperhake, J., Poets, C. F., Weis, C., Schlaud, M., Bajanowski, T., Wedekind, H., Breithardt, G., Debertin, A. S., Tönjes, H., Tschernig, T., Pabst, R., Tröger, H. D., Krill, A., Hame, M., Bouška, I., Ježková, J., Kernbach-Wighton, G., Wense, A. v. d., Kijewski, H., Goeke, M., Weber, B., Staak, M., Dettmeyer, R., Driever, F., Becker, A., Wiestler, O. D., Verhoff, M. A., Woenckhaus, J., Hauri-Bionda, R., Strehler, M., Bär, W., Ohshima, T., Takayasu, T., Kondo, T., Sato, Y., Tarbah, Fuad A., Mahler, Hellmut, Temme, Oliver, Daldrup, Thomas, Pötsch, Lucia, Emmerich, Patricia, Skopp, Gisela, Andresen, H., Schmoldt, A., Thurau, K., Vogt, S., Große-Perdekamp, M., Pufal, E., Sykutera, M., Rochholz, G., Lis, G., Sliwka, K., Zörntlein, S., Röhrich, J., Pötsch, L., Becker, J., Mattern, Rainer, Yamamoto, Yoshiko, Hayase, Tamaki, Yamamoto, Keiichi, Piette, Michel H. A., De Letter, Els A., Cordonnier, Jan, Schultes, A., Pluisch, F., Darok, M., Kollroser, M., Mannweiler, S., Babel, B., Magerl, H., Mahfoud, B., Stein, S., Iwersen-Bergmann, S., Risser, D., Hönigschnabl, S., Stichenwirth, M., Sebald, D., Kaff, A., Schneider, B., Vycudilik, W., Bauer, G., Reitz, E., Kimont, H. -G., Molnár, A., Jeszenszky, E., Benkó, A., Száz, E., Varga, T., Mayr, N. P., Schmidbauer, S., Hallfeldt, K., Bank, A., Iffland, R., Schuff, A., Fischer, T., Weingarten, Y., Alt, A., Janda, I., Wurst, F. M., Seidl, S., Seitler, C., Haag-Dawoud, Munira, Beike, J., Vennemann, B., Köhler, H., Hendreich, F. -I., Giebe, W., Reimann, I., Werner, R., Klein, A., Schulz, K., Feischer, D., Erfurt, Ch., Arnold, R., Winnefeld, K., Riepert, T., Iffland, R., Longauer, F., Kardošovå, V., Anders, S., Hildebrand, E., Schulz, F., Möbus, U., Jaroß, W., Wittig, H., Schmidt, U., Hauptmann, K., Krause, D., Prudlow, B., Rohner, T., Molz, G., Früchtnicht, W., Hoppe, B., Henßge, C., Althaus, L., Herbst, J., Preiß, U., Stein, C., Glenewinkel, F., Leinzinger, E. P., Lászik, A., Soós, M., Hubay, M., Sótonyi, P., Schliff, A., Gatternig, R., Hering, S., Edelmann, J., Plate, I., Michael, M., Kuhlisch, E., Szibor, R., von Wurmb, N., Hammer, U., Meissner, D., Kirches, E., Dietzmann, K., Pfeiffer, H., Ortmann, C., Meißner, C., Mohamed, S. A., Warnk, H., Gehlsen-Lorenzen, A., Oehmichen, M., Heidorn, F., Henkel, R., Schulz, M. M., Reichert, W., Mattern, R., Baasner, A., Banaschak, S., Schäfer, C., Benecke, M., Reibe, S., Barksdale, Larry, Sundermeier, Jon, Ratcliffe, Brett C., Lutz, S., Hohoff, C., Schürenkamp, M., Kahle, C., Fieguth, A., Ritz-Timme, S., Laumeier, I., Schütz, H. W., Schulte-Mönting, J., Chaudri, S., Welti, M., Dittmann, V., Olze, A., Schmeling, A., Reisinger, W., Klotzbach, H., Gabriel, P., Demir, T., Huckenbeck, W., Reuhl, J., Schuster, R., Maxeiner, H., Bockholdt, B., Jachau, K., Kuchheuser, W., Försterling, T., Ehrlich, E., Besselmann, M., Du Chesne, A., Albrecht, U. -V., Guan, D. W., Dreßler, J., Voigtmann, K., Müller, E., Vieler, S., Kirchner, A., Humpert, M., Breitmeier, D., Mansouri, F., Wyler, D., Marty, W., Sigrist, Th., Zollinger, U., Meyer, U., Allmen, G. v., Karger, B., Hoekstra, A., Stehmann, B., Schmidt, P. F., Peschel, O., Vollmar, C., Szeimies, U., Rothschild, M. A., Kegel, D., Klatt, A., Klatt, C., Briese, B. -H., Schyma, C., Schyma, P., Angetter, Daniela, Perdekamp, M. Große, Sun, Y., Guttenberge, R., Riede, U. -N., Poetsch, M., Seefeldt, S., Maschke, M., Lignitz, E., Zeller, M., Wehner, H. -D., Czarnetzki, A., Blin, N., Bender, K., Emmerich, P., Pádár, Zs., Egyed, B., Kemény, G., Woller, J., Füredi, S., Balogh, I., Cremer, U., Scheil, H. -G., Schiwy-Bochat, K. -H., Althoff, H., Immel, U. -D., Tatschner, Th., Lang, C., Versmold, D., Reineke, Th., Mall, G., Dahlmann, F., Büttner, A., Hubig, M., Rötzscher, K., Grundmann, C., Oritani, S., Peter, J., Popov, V., Olejnik, V., Khokhlov, V. D., Stiller, D., Romanowski, U., Kleiber, M., Klupp, N., Mortinger, H., Chadová, L., Bouška, I., Toupalik, P., Schnabel, A., Lutz, F. -U., Crivellaro, A., Strauch, H., Dan, Dermengiu, Silvia, Dermengiu, Buda, Octavian, Kandolf, R., Kaiser, R., Eis-Hübinger, A. M., Kobek, M., Jankowski, Z., Rygol, K., Kulikowska, J., Martin, H., Kolbow, K., Keil, W., Wang, Huijun, Ding, Yanqing, Huang, Guangzhao, Wu, Zhongbi, Wehner, F., Subke, J., Zdravkovic, M., Otasevic, V., Rostov, M., Karadzic, R., Kildüschov, E. M., Buromski, I. W., Plaksin, W. O., Wendland, A., Spiridonow, W. A., Sabusow, J. G., Kalinin, J. P., Heide, S., Schmidt, V., Wiegand, P., Kleiber, M., Demmler, G., Zack, F., Reischle, S., Schönpflug, M., Beier, G., Berchtenbreiter, C., Lackner, K., Jendrusch, B., Wolf, H., Buhmann, D., Summa, H., Matschke, J., Stürenburg, H. J., Junge, M., Wischhusen, F., Müldner, C., Schröder, A., Kaiser, E., Lasczkowski, G., Hofbauer, V., Eberl, N., Thomson, H., Tatschner, T., Milz, S., Gazov, E., Trübner, K., Brenner, M., Tsokos, M., Anders, S., Paulsen, F., Reith, K., Bratzke, H., Schapfeld, R., Graefe-Kirci, U., Stiller, D., Trübner, K., and Schäfer, A. Th.

Published
2000
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12. Half-Sandwich Group 4 Metal Siloxy and Silsesquioxane Complexes:  Soluble Model Systems for Silica-Grafted Olefin Polymerization Catalysts

Author

Duchateau, R., Cremer, U., Harmsen, R. J., Mohamud, S. I., Abbenhuis, H. C. L., Santen, R. A. van, Meetsma, A., Thiele, S. K.-H., Tol, M. F. H. van, and Kranenburg, M.

Abstract

The cuboctameric hydroxysilsesquioxane (c-C5H9)7Si8O12(OH) (2), obtained after hydrolysis of (c-C5H9)7Si8O12Cl (1), and triphenylsilanol have been applied as model supports for silica-grafted olefin polymerization catalysts. The ligands were introduced on group 4 metals by either chloride metathesis or protonolysis. Treatment of Cp‘ ‘MCl3 (M = Ti, Zr; Cp‘ ‘ = 1,3-C5H3(SiMe3)2) with silsesquioxane and siloxylithium or -thallium salts, [(c-C5H9)7Si8O13]M‘ (M‘ = Tl (3), Li (4), Li·TMEDA (5)) or Ph3SiOTl gave either the dichloride complexes Cp‘ ‘[(c-C5H9)7Si8O13]MCl2 (M = Ti (6a), Zr (7a)) and Cp‘ ‘[Ph3SiO]TiCl2 (8a) or the monochloride species Cp‘ ‘[(c-C5H9)7Si8O13]2MCl (M = Ti (6b), Zr (7b)) and Cp‘ ‘[Ph3SiO]2MCl (M = Ti (8b), Zr (9)). Similarly, protonolysis of Cp‘ ‘MR3 with the silanols 2 and Ph3SiOH yielded the corresponding silsesquioxane bis(alkyl) complexes Cp‘ ‘[(c-C5H9)7Si8O13]TiR2 (R = CH2Ph (10a), Me (10b)) and triphenylsiloxy bis(alkyl) compounds Cp‘ ‘[Ph3SiO]MR2 (M = Ti, R = CH2Ph (11a), Me (11b); M = Zr, R = CH2Ph (12a)) and the monobenzyl complex Cp‘ ‘[Ph3SiO]2ZrCH2Ph (12b). When activated with MAO, not only the dichloride complexes (6a, 7a, 8a) but also the monochlorides (6b, 7b, 8b, 9) yield active ethylene polymerization catalysts. The observation that even complexes containing a tridentate silsesquioxane ligand, [(c-C5H9)7Si8O12]MCp‘ ‘ (M = Ti (13), Zr (14)), form active ethylene polymerization catalysts when activated with MAO indicates that silsesquioxane and siloxy ligands are easily substituted by MAO. The silsesquioxane and siloxy bis(alkyl) complexes (10, 11, 12a) form active olefin polymerization catalysts when activated with B(C6F5)3, which leaves the M−O bond unaffected. Although the different cone angles of (c-C5H9)7Si8O13 (155°) and Ph3SiO (132°) suggest otherwise, the effective steric congestion around the metal center of (c-C5H9)7Si8O13- and Ph3SiO-stabilized complexes was found to be reasonably comparable. The electronic differences between (c-C5H9)7Si8O12(OH) (2) and Ph3SiOH are more pronounced. pKa measurements and DFT calculations indicate that 2 is notably more Brønsted acidic and electron withdrawing than Ph3SiOH.

Published
1999

15. Petechial bleedings in sudden infant death.

Author

Fracasso T, Vennemann M, Klöcker M, Bajanowski T, Brinkmann B, Pfeiffer H, Bach P, Bockholdt B, Bohnert M, Cremer U, Deml U, Freislederer A, Heide S, Huckenbeck W, Jachau K, Kaatsch HJ, Klein A, Kleemann WJ, Larsch KP, Fieguth A, Leukel HW, Mützel E, Rublack F, Sperhake J, Zimmer G, and Zweihoff R

Subjects
Asphyxia diagnosis, Asphyxia pathology, Autopsy, Diagnosis, Differential, Female, Forensic Pathology, Humans, Infant, Male, Skin pathology, Thorax pathology, Hemorrhage pathology, Postmortem Changes, Sudden Infant Death
Abstract

The autopsy reports of 484 cases of deceased infants (201 females, 283 males) were analysed retrospectively for the existence of external and internal petechial bleedings (PET). The cases were divided into five groups on the basis of the cause of death (sudden infant death syndrome, sepsis, airway infections, asphyxia and trauma). Internal PET (pleural, pericardial, epicardial, thymic and peritoneal) were observed in each group with a lower prevalence in cases of trauma. The highest prevalence of external (cutaneous and conjunctival) PET was detected in cases of asphyxia (38% and 31%, respectively). However, even if with low prevalence, such bleedings were detected in every group. Factors like sex, age, cardiopulmonary resuscitation and its duration did not influence the presence of PET. The detection of external PET at autopsy is a suspicious finding that suggests asphyxia. Because of the possible natural origin of these bleedings, the medicolegal investigation has to be as complete as possible and has to include histology as mandatory.

Published
2011
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16. The Diammoniates of dipotassiumtetraethinylozincate and -cadmate: K2M(C2H)4.2NH3 (M = Zn, Cd).

Author

Cremer U, Pantenburg I, and Ruschewitz U

Abstract

By reaction of KC(2)H and K(2)Zn(CN)(4) in liquid ammonia, the diammoniate K(2)Zn(C(2)H)(4).2NH(3) was obtained. K(2)Cd(C(2)H)(4).2NH(3) was synthesized by reacting KC(2)H, Cd(NH(2))(2), and acetylene in liquid ammonia. The crystal structures of the air and temperature sensitive compounds were determined by X-ray single crystal diffraction at low temperatures (T = 170 K). Both compounds crystallize in the monoclinic space group I2/a (No. 15) with Z = 4. K(2)Zn(C(2)H)(4).2NH(3): a = 7.289(1) A, b = 12.765(2) A, c = 14.066(2) A, beta = 98.11(2) degrees. K(2)Cd(C(2)H)(4).2NH(3): a = 7.444(1) A, b = 12.619(3) A, c = 14.304(2) A, beta = 98.94(1) degrees. Characteristic structural motifs are tetrahedral [M(C(2)H)(4)](2-) fragments (M = Zn, Cd) and zigzag chains of edge sharing distorted (C(2)H)(6) octahedra centered by potassium ions. These zigzag chains are connected by a second type of crystallographically distinct potassium ions that also bind to two ammonia molecules.

Published
2003
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17. [Conceiling the cadaver in masonry and cement].

Author

Madea B, Cremer U, and Schiwy-Bochat KH

Subjects
Adult, Autopsy legislation & jurisprudence, Cause of Death, Female, Humans, Infant, Infanticide legislation & jurisprudence, Male, Wounds, Nonpenetrating pathology, Construction Materials, Homicide legislation & jurisprudence, Postmortem Changes
Abstract

Encasing with concrete and/or bricks are relatively rare forms of hiding or disposing of a body; criminologically, cases of this kind are often treated as "matters involving a missing person" at first. The article describes the circumstances and findings of 2 cases in which bodies were encased with concrete. Under the aspects of reconstruction it is of importance that bodies may be preserved quite well in concrete, which allows not only identification of the victim but also determination of the cause of death even after a prolonged post-mortem interval, the more so as occasionally tools used for committing the offense are also encased together with the body.

Published
2003

18. Cytogenetic and DNA-fingerprint characterization of choriocarcinoma cell lines and a trophoblast/choriocarcinoma cell hybrid.

Author

Frank HG, Gunawan B, Ebeling-Stark I, Schulten HJ, Funayama H, Cremer U, Huppertz B, Gaus G, Kaufmann P, and Füzesi L

Subjects
Cell Fusion, Chromosome Banding, Female, Humans, In Situ Hybridization, Fluorescence, Pregnancy, Tumor Cells, Cultured, Choriocarcinoma genetics, DNA Fingerprinting, Hybrid Cells, Karyotyping, Trophoblasts, Uterine Neoplasms genetics
Abstract

We report the successful fusion of human choriocarcinoma cells with normal human trophoblast cells to a choriocarcinoma/trophoblast hybrid. The hybrid cells ACH1P were derived from fusion of primary male trophoblast cells with the HGPRT-defective choriocarcinoma cell line AC1-1. The karyotypes of the parental choriocarcinoma cell line JEG-3, its HGPRT-defective mutant clones AC1-1, AC1-5, and AC1-9, and the choriocarcinoma/trophoblast hybrid ACH1P are presented, together with a detailed characterization of the AC1-specific chromosomal marker add(X)(q26) using conventional cytogenetic banding techniques and multiplex-fluorescence in situ hybridization (M-FISH). To our knowledge, this is the first report of a stably proliferating human cell hybrid of trophoblastic origin, providing a unique cell culture model to study trophoblast-related invasion and its underlying genetic mechanisms.

Published
2000
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19. [Errors in autopsy in Germany. Results of a multicenter study (I)].

Author

Brinkmann B, Banaschak S, Bratzke H, Cremer U, Drese G, Erfurt C, Giebe W, Lang C, Lange E, Peschel O, Philipp KP, Püschel K, Risse M, Tutsch-Bauer E, Vock R, and Du Chesne A

Subjects
Accidents legislation & jurisprudence, Adolescent, Adult, Aged, Aged, 80 and over, Cause of Death, Child, Child, Preschool, Death Certificates legislation & jurisprudence, Diagnostic Errors, Female, Humans, Infant, Infant, Newborn, Male, Malpractice legislation & jurisprudence, Middle Aged, Suicide legislation & jurisprudence, Wounds and Injuries pathology, Autopsy legislation & jurisprudence, Homicide legislation & jurisprudence
Published
1997

21. [Fulminant streptococcal myositis].

Author

Schiwy-Bochat KH and Cremer U

Subjects
Adult, Diagnostic Errors, Female, Humans, Muscles microbiology, Muscles pathology, Myositis pathology, Shock, Septic pathology, Streptococcal Infections pathology, Streptococcus pyogenes ultrastructure
Published
1993

23. [Forensic medicine and morphologic aspects of fatal amniotic fluid aspiration].

Author

Althoff H and Cremer U

Subjects
Cesarean Section, Female, Humans, Infant, Newborn, Lung pathology, Amniotic Fluid analysis, Asphyxia Neonatorum pathology, Malpractice legislation & jurisprudence, Pneumonia, Aspiration pathology
Abstract

The massive aspiration of amniotic fluid as one cause of a fatal postpartal asphyxia will be demonstrated under the aspect of preliminary criminal law proceedings against physicians because of medical negligence. The pathomorphologically established diagnosis of a fatal aspiration of amniotic fluid supposes extensive and systematic quantitative histological examination of both lungs. The technique of histological cross sections through the entire lung combined with morphometry is a suitable method to exactly record the alterations of bronchi and lung parenchyma by aspiration of amniotic fluid and their complications, such as interstitial emphysema.

Published
1989
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25. [The dangers of alcohol - the situation in the Federal Republic of Germany].

Author

Cremer U

Subjects
Adolescent, Adult, Alcoholism epidemiology, Female, Germany, West, Humans, Male, Middle Aged, Alcohol Drinking, Alcoholism prevention & control, Health Education
Abstract

In 1975 an action programme on the prevention and containment of alcohol abuse was decided upon for the Federal Republic of Germany. Many items of this program are tasks of a long standing nature. Many an effort has since then led to success: the population has increasingly become aware of the dangers of alcohol abuse. The number of people drinking alcoholic beverages daily or almost daily decreased, the number of those drinking hardly ever or never increased. The group of people in danger of becoming dependent on alcohol grew smaller and alcohol consumption per head of population remained at the same level. The groups in need of special attention are children and young people and here particularly girls because of the fetal alcohol syndrome, as well as parents and teachers because they are called upon to set an example. Health education for these particular groups of people is of prime importance because it is essentially responsible for the success in combating alcohol abuse. In future, however, even more effective strategies for health education and research will have to be developed.

Published
1983
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26. [Infanticide as a sequel of long-term unusual parental abuse].

Author

Cremer U

Subjects
Child, Preschool, Humans, Male, Multiple Trauma pathology, Skin pathology, Burns pathology, Child Abuse legislation & jurisprudence, Infanticide legislation & jurisprudence
Abstract

Reported is an uncommon case of battered-child syndrome by parents which caused the child's death. A lot of signs indicating multifarious and serious injuries are described. The causes of violence against the child--including those on an ethnological background- are discussed.

Published
1988

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