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1,104 results on '"Cremer, Olaf L."'

8. Glycan-specific IgM is critical for human immunity to Staphylococcus aureus

Author

Hendriks, Astrid, Kerkman, Priscilla F., Varkila, Meri R.J., Haitsma Mulier, Jelle L.G., Ali, Sara, ten Doesschate, Thijs, van der Vaart, Thomas W., de Haas, Carla J.C., Aerts, Piet C., Cremer, Olaf L., Bonten, Marc J.M., Nizet, Victor, Liu, George Y., Codée, Jeroen D.C., Rooijakkers, Suzan H.M., van Strijp, Jos A.G., and van Sorge, Nina M.

Published
2024
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10. A pragmatic approach to estimating average treatment effects from EHR data: the effect of prone positioning on mechanically ventilated COVID-19 patients

Author

Izdebski, Adam, Thoral, Patrick J., Lalisang, Robbert C. A., McHugh, Dean M., Gommers, Diederik, Cremer, Olaf L., Bosman, Rob J., Rigter, Sander, Wils, Evert-Jan, Frenzel, Tim, Dongelmans, Dave A., de Jong, Remko, Peters, Marco A. A., Kamps, Marlijn J. A, Ramnarain, Dharmanand, Nowitzky, Ralph, Nooteboom, Fleur G. C. A., de Ruijter, Wouter, Urlings-Strop, Louise C., Smit, Ellen G. M., Mehagnoul-Schipper, D. Jannet, Dormans, Tom, de Jager, Cornelis P. C., Hendriks, Stefaan H. A., Achterberg, Sefanja, Oostdijk, Evelien, Reidinga, Auke C., Festen-Spanjer, Barbara, Brunnekreef, Gert B., Cornet, Alexander D., Tempel, Walter van den, Boelens, Age D., Koetsier, Peter, Lens, Judith, Faber, Harald J., Karakus, A., Entjes, Robert, de Jong, Paul, Rettig, Thijs C. D., Arbous, Sesmu, Fleuren, Lucas M., Dam, Tariq A., Tonutti, Michele, de Bruin, Daan P., Elbers, Paul W. G., and Cinà, Giovanni

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence
Abstract

Despite the recent progress in the field of causal inference, to date there is no agreed upon methodology to glean treatment effect estimation from observational data. The consequence on clinical practice is that, when lacking results from a randomized trial, medical personnel is left without guidance on what seems to be effective in a real-world scenario. This article proposes a pragmatic methodology to obtain preliminary but robust estimation of treatment effect from observational studies, to provide front-line clinicians with a degree of confidence in their treatment strategy. Our study design is applied to an open problem, the estimation of treatment effect of the proning maneuver on COVID-19 Intensive Care patients.

Published
2021

12. Assess and validate predictive performance of models for in-hospital mortality in COVID-19 patients: A retrospective cohort study in the Netherlands comparing the value of registry data with high-granular electronic health records

Author

Vagliano, Iacopo, Schut, Martijn C., Abu-Hanna, Ameen, Dongelmans, Dave A., de Lange, Dylan W., Gommers, Diederik, Cremer, Olaf L., Bosman, Rob J., Rigter, Sander, Wils, Evert-Jan, Frenzel, Tim, de Jong, Remko, Peters, Marco A.A., Kamps, Marlijn J.A., Ramnarain, Dharmanand, Nowitzky, Ralph, Nooteboom, Fleur G.C.A., de Ruijter, Wouter, Urlings-Strop, Louise C., Smit, Ellen G.M., Mehagnoul-Schipper, D. Jannet, Dormans, Tom, de Jager, Cornelis P.C., Hendriks, Stefaan H.A., Achterberg, Sefanja, Oostdijk, Evelien, Reidinga, Auke C., Festen-Spanjer, Barbara, Brunnekreef, Gert B., Cornet, Alexander D., van den Tempel, Walter, Boelens, Age D., Koetsier, Peter, Lens, Judith, Faber, Harald J., Karakus, A., Entjes, Robert, de Jong, Paul, Rettig, Thijs C.D., Reuland, M.C., Arbous, Sesmu, Fleuren, Lucas M., Dam, Tariq A., Thoral, Patrick J., Lalisang, Robbert C.A., Tonutti, Michele, de Bruin, Daan P., Elbers, Paul W.G., and de Keizer, Nicolette F.

Published
2022
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14. Lupus anticoagulant associates with thrombosis in patients with COVID‐19 admitted to intensive care units: A retrospective cohort study

Author

Noordermeer, Tessa, Schutgens, Roger E.G., Visser, Chantal, Rademaker, Emma, de Maat, Moniek P.M., Jansen, A.J. Gerard, Limper, Maarten, Cremer, Olaf L., Kruip, Marieke J.H.A., Endeman, Henrik, Maas, Coen, de Laat, Bas, Urbanus, Rolf T., van de Beek, D., Brouwer, M.C., de Bruin, S., Coppens, M., van Es, N., van Haaps, T.F., Juffermans, N.P., Muller, M.C.A., Vlaar, A.P.J., Hertogh, C.M.P.M., Heunks, L.M.A., Hugtenburg, J.G., van Kooten, J., Nossent, E.J., Smulders, Y., Tuinman, P.R., Vonk Noordegraaf, A., Grootenboers, M.J.J.H., van Guldener, C., Kant, M., Lansbergen, A., Faber, J., Hajer, G., Stemerdink, A., van den Akker, J., Bierings, R., Endeman, H., Goeijenbier, M., Hunfeld, N.G.M., van Gorp, E.C.M., Gommers, D.A.M.P.J., Koopmans, M.P.G., Kruip, M.J.H.A., Kuiken, T., Langerak, T., Leebeek, Lauw, M.N., de Maat, M.P.M., Noack, D., Paats, M.S., Raadsen, M.P., Rockx, B., Rokx, C., Schurink, C.A.M., Tong‐Minh, K., van den Toorn, L., den Uil, C.A., Visser, C., Boutkourt, F., Roest, T., Douma, R.A., de Haan, L.R., ten Wolde, M., Bemelmans, R.H.H., Festen, B., Stads, S., de Jager, C.P.C., Simons, K.S., Antoni, M.L., Bos, M.H., Burggraaf, J.L.I., Cannegieter, S.C., Eikenboom, H.C.J., den Exter, P.L., Geelhoed, J.J.M., Huisman, M.V., de Jonge, E., Kaptein, F.H.J., Klok, F.A., Kroft, L.J.M., Lijfering, W.M., Nab, L., Ninaber, M.K., Putter, H., Ramai, S.R.S., da Rocha Rondon, A.M., Roukens, A.H.E., Stals, M.A.M., Versteeg, H.H., Vliegen, H.W., van Vlijmen, B.J.M., van de Berg, T., Bruggemann, R., van Bussel, B.C.T., ten Cate, H., ten Cate‐Hoek, A., Hackeng, T.M., Henskens, ir.Y., Hulshof, A., Mulder, M., Olie, R.H., Schurgers, L., Spaetgens, B., Spronk, H., Winckers, K., Nieuwenhuizen, L., Franken, B., Schrover, I.M., de Waal, E.G.M., Beishuizen, A., Cornet, A., Krabbe, J., Kramers, K., Leentjens, J., de Mast, Q., Middeldorp, S., Brouwer, R.E., Ellerbroek, J.L.J., Tijmensen, J., Hovens, M.M C., Oostdijk, E.A.N., Westerhof, B.D., Faber, L.M., van den Biggelaar, M., Meijers, J.C.M., Voorberg, J., Kevenaar, M.E., Soei, Y.L., Wils, E.J., Croles, F.N., de Laat, B., Kamphuisen, P.W., Vink, R., Lisman, T., Meijer, K., van Tichelaar, Y.I.G., Cremer, O.L., Geersing, G., Kaasjager, H.A.H., Kusadasi, N., Huisman, A., Maas, C., Nijkeuter, M., Schutgens, R.E.G., Creveldkliniek, Van, Urbanus, R.T., Westerink, J., Faber, H.J., Koster, S.C.E., van Montfort, P., and van Twist, D.J.L.

Published
2022
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16. Predicting responders to prone positioning in mechanically ventilated patients with COVID-19 using machine learning

Author

Dam, Tariq A., Roggeveen, Luca F., van Diggelen, Fuda, Fleuren, Lucas M., Jagesar, Ameet R., Otten, Martijn, de Vries, Heder J., Gommers, Diederik, Cremer, Olaf L., Bosman, Rob J., Rigter, Sander, Wils, Evert-Jan, Frenzel, Tim, Dongelmans, Dave A., de Jong, Remko, Peters, Marco A. A., Kamps, Marlijn J. A., Ramnarain, Dharmanand, Nowitzky, Ralph, Nooteboom, Fleur G. C. A., de Ruijter, Wouter, Urlings-Strop, Louise C., Smit, Ellen G. M., Mehagnoul-Schipper, D. Jannet, Dormans, Tom, de Jager, Cornelis P. C., Hendriks, Stefaan H. A., Achterberg, Sefanja, Oostdijk, Evelien, Reidinga, Auke C., Festen-Spanjer, Barbara, Brunnekreef, Gert B., Cornet, Alexander D., van den Tempel, Walter, Boelens, Age D., Koetsier, Peter, Lens, Judith, Faber, Harald J., Karakus, A., Entjes, Robert, de Jong, Paul, Rettig, Thijs C. D., Arbous, Sesmu, Vonk, Sebastiaan J. J., Machado, Tomas, Herter, Willem E., de Grooth, Harm-Jan, Thoral, Patrick J., Girbes, Armand R. J., Hoogendoorn, Mark, and Elbers, Paul W. G.

Published
2022
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19. Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study

Author

Peters-Sengers, Hessel, Butler, Joe M., Uhel, Fabrice, Schultz, Marcus J., Bonten, Marc J., Cremer, Olaf L., and Scicluna, Brendon P.

Subjects
Infection -- Patient outcomes -- Comparative analysis, Health care industry
Abstract

Purpose There is limited knowledge on how the source of infection impacts the host response to sepsis. We aimed to compare the host response in sepsis patients with a single, known source at admission (< 24 h) to the intensive care unit. Methods From the molecular diagnosis and risk stratification of sepsis (MARS) prospective cohort, we measured 16 plasma host response biomarkers reflective of key host response pathways in 621 sepsis patients. In a subgroup (n = 335), blood leukocyte transcriptomes were compared between the sources. Differences in clinical patient profiles and survival were compared in the whole sepsis cohort (n = 2019). Results The plasma biomarker cohort was categorized into sepsis originating from the respiratory tract (n = 334, 53.8%), abdomen (n = 159, 25.6%), urinary tract (n = 44, 7.1%), cardiovascular (n = 41, 6.6%), central nervous system (CNS) (n = 18, 2.9%), or skin (n = 25, 4%). This analysis revealed stronger inflammatory and cytokine responses, loss of vascular integrity and coagulation activation in abdominal sepsis relative to respiratory. Endothelial cell activation was prominent in urinary, cardiovascular and skin infections, while CNS infection was associated with the least host response aberrations. The leukocyte transcriptional response showed the largest overlap between abdominal and pulmonary infections (76% in common); notable differences between the sources were detected regarding hemostasis, cytokine signaling, innate and adaptive immune, and metabolic transcriptional pathways. After adjustment for confounders, the source of infection remained an independent contributor to 30-day mortality (unadjusted p = 0.001, adjusted p = 0.028). Conclusion Sepsis heterogeneity is partly explained by source-specific host response dysregulations and should be considered when selecting patients for trials testing immune modulatory drugs., Author(s): Hessel Peters-Sengers [sup.1] [sup.2], Joe M. Butler [sup.1] [sup.2], Fabrice Uhel [sup.1] [sup.2], Marcus J. Schultz [sup.3] [sup.4] [sup.5] [sup.6], Marc J. Bonten [sup.7] [sup.8], Olaf L. Cremer [sup.9], [...]

Published
2022
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21. Biomarker patterns in patients with cardiogenic shock versus septic shock

Author

Peters, Elma J., primary, Frydland, Martin S., additional, Hassager, Christian, additional, Bos, Lieuwe D.J., additional, van Vught, Lonneke A., additional, Cremer, Olaf L., additional, Møller, Jacob E., additional, van den Born, Bert-Jan H., additional, Vlaar, Alexander P.J., additional, and Henriques, Jose P.S., additional

Published
2024
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23. Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis

Author

van Vught, Lonneke A., Uhel, Fabrice, Ding, Chao, van‘t Veer, Cees, Scicluna, Brendon P., Peters‐Sengers, Hessel, Klein Klouwenberg, Peter M.C., Nürnberg, Peter, Cremer, Olaf L., Schultz, Marcus J., van der Poll, Tom, de Beer, Friso M., Bos, Lieuwe D.J., Glas, Gerie J., Hoogendijk, Arie J., van Hooijdonk, Roosmarijn T.M., Horn, Janneke, Huson, Mischa A., Schouten, Laura R.A., Straat, Marleen, Wieske, Luuk, Wiewel, Maryse A., Witteveen, Esther, Bonten, Marc J.M., Cremer, Olaf M., Ong, David S.Y., Frencken, Jos F., Koster‐Brouwer, Maria E., van de Groep, Kirsten, and Verboom, Diana M.

Published
2021
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24. Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study

Author

van Akkeren, Jesse P., Algera, Anna Geke, Algoe, Cheetel K., van Amstel, Rombout B., Baur, Onno L., van de Berg, Pablo, van den Berg, Alida E., Bergmans, Dennis C.J.J., van den Bersselaar, Dido I., Bertens, Freke A., Bindels, Alexander J.G.H., de Boer, Milou M., den Boer, Sylvia, Boers, Leonoor S., Bogerd, Margriet, Bos, Lieuwe D.J., Botta, Michela, Breel, Jennifer S., de Bruin, Hendrik, de Bruin, Sanne, Bruna, Caro L., Buiteman-Kruizinga, Laura A., Cremer, Olaf L., Determann, Rogier M., Dieperink, Willem, Dongelmans, Dave A., Franke, Hildegard S., Galek-Aldridge, Michal S., de Graaff, Mart J., Hagens, Laura A., Haringman, Jasper J., van der Heide, Sebastiaan T., van der Heiden, Pim L.J., Heijnen, Nanon F.L., Hiel, Stephan J.P., Hoeijmakers, Lotte L., Hol, Liselotte, Hollmann, Markus W., Hoogendoorn, Marga E., Horn, Janneke, van der Horst, Robrecht, Ie, Evy L.K., Ivanov, Dimitri P., Juffermans, Nicole, Kho, Eline, de Klerk, Eline S., Koopman-van Gemert, Ankie W.M.M., Koopmans, Matty, Kucukcelebi, Songul, Kuiper, Michael A., de Lange, Dylan W., van Mourik, Niels, Nijbroek, Sunny G.L.H., Onrust, Marisa, Oostdijk, Evelien A.N., Paulus, Frederique, Pennartz, Charlotte J., Pillay, Janesh, Pisani, Luigi, Purmer, Ilse M., Rettig, Thijs C.D., Roozeman, Jan-Paul, Schuijt, Michiel T.U., Schultz, Marcus J., Serpa Neto, Ary, Sleeswijk, Mengalvio E., Smit, Marry R., Spronk, Peter E., Stilma, Willemke, Strang, Aart C., Tsonas, Anissa M., Tuinman, Pieter R., Valk, Christel M.A., Veen-Schra, Felicia L., Veldhuis, Lars I., van Velzen, Patricia, van der Ven, Ward H., Vlaar, Alexander P.J., van Vliet, Peter, van der Voort, Peter H.J., van Welie, Louis, Wesselink, Henrico J.F.T., van der Wier-Lubbers, Hermien H., van Wijk, Bas, Winters, Tineke, Wong, Wing Yi, van Zanten, Arthur R.H., Tsonas, Anissa M, Boers, Leonoor S, Bos, Lieuwe D J, Dongelmans, Dave A, Hollmann, Marcus W, Vlaar, Alexander P J, Schultz, Marcus J, and Neto, Ary Serpa

Published
2021
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26. Large-scale ICU data sharing for global collaboration: the first 1633 critically ill COVID-19 patients in the Dutch Data Warehouse

Author

Fleuren, Lucas M., de Bruin, Daan P., Tonutti, Michele, Lalisang, Robbert C. A., Elbers, Paul W. G., Gommers, Diederik, and Cremer, Olaf L.

Subjects
Health care industry
Abstract

Author(s): Lucas M. Fleuren [sup.1], Daan P. de Bruin [sup.2], Michele Tonutti [sup.2], Robbert C. A. Lalisang [sup.2], Paul W. G. Elbers [sup.1], Diederik Gommers [sup.1], Olaf L. Cremer [sup.1], [...]

Published
2021
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29. Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study

Author

Uhel, Fabrice, Peters-Sengers, Hessel, Falahi, Fahimeh, Scicluna, Brendon P., van Vught, Lonneke A., Bonten, Marc J., and Cremer, Olaf L.

Subjects
Mortality -- Netherlands -- Analysis, Infection -- Research -- Health aspects -- Analysis, Health care industry, University of Amsterdam
Abstract

Purpose Sepsis is the most frequent cause of acute kidney injury (AKI). The 'Acute Disease Quality Initiative Workgroup' recently proposed new definitions for AKI, classifying it as transient or persistent. We investigated the incidence, mortality, and host response aberrations associated with transient and persistent AKI in sepsis patients. Methods A total of 1545 patients admitted with sepsis to 2 intensive care units in the Netherlands were stratified according to the presence (defined by any urine or creatinine RIFLE criterion within the first 48 h) and evolution of AKI (with persistent defined as remaining > 48 h). We determined 30-day mortality by logistic regression adjusting for confounding variables and analyzed 16 plasma biomarkers reflecting pathways involved in sepsis pathogenesis (n = 866) and blood leukocyte transcriptomes (n = 392). Results AKI occurred in 37.7% of patients, of which 18.4% was transient and 81.6% persistent. On admission, patients with persistent AKI had higher disease severity scores and more frequently had severe (injury or failure) RIFLE AKI stages than transient AKI patients. Persistent AKI, but not transient AKI, was associated with increased mortality by day 30 and up to 1 year. Persistent AKI was associated with enhanced and sustained inflammatory and procoagulant responses during the first 4 days, and a more severe loss of vascular integrity compared with transient AKI. Baseline blood gene expression showed minimal differences with respect to the presence or evolution of AKI. Conclusion Persistent AKI is independently associated with sepsis mortality, as well as with sustained inflammatory and procoagulant responses, and loss of vascular integrity as compared with transient AKI., Author(s): Fabrice Uhel [sup.1], Hessel Peters-Sengers [sup.1], Fahimeh Falahi [sup.1], Brendon P. Scicluna [sup.1] [sup.2], Lonneke A. van Vught [sup.1], Marc J. Bonten [sup.3] [sup.4], Olaf L. Cremer [sup.5], Marcus [...]

Published
2020
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30. Two-step interpretable modeling of ICU-AIs

Author

Lancia, Giacomo, Varkila, Meri, Cremer, Olaf L., Spitoni, Cristian, Lancia, Giacomo, Varkila, Meri, Cremer, Olaf L., and Spitoni, Cristian

Abstract

We present a novel methodology for integrating high resolution longitudinal data with the dynamic prediction capabilities of survival models. The aim is two-fold: to improve the predictive power while maintaining the inter- pretability of the models. To go beyond the black box paradigm of artificial neural networks, we propose a parsimonious and robust semi-parametric approach (i.e., a landmarking competing risks model) that combines routinely collected low-resolution data with predictive features extracted from a convolutional neural network, that was trained on high resolution time-dependent information. We then use saliency maps to analyze and explain the extra predictive power of this model. To illustrate our methodology, we focus on healthcare-associated infections in patients admitted to an intensive care unit.

Published
2024

31. The association between preoperative multidisciplinary team care and patient outcome in frail patients undergoing cardiac surgery

Author

Infection & Immunity, Sepsis and Inflammation, MS Geriatrie, Circulatory Health, Medische Staf Intensive Care, Onderzoek, Smoor, Rosa M, van Dongen, Eric P A, Daeter, Edgar J, Emmelot-Vonk, Marielle H, Cremer, Olaf L, Vernooij, Lisette M, Noordzij, Peter G, Infection & Immunity, Sepsis and Inflammation, MS Geriatrie, Circulatory Health, Medische Staf Intensive Care, Onderzoek, Smoor, Rosa M, van Dongen, Eric P A, Daeter, Edgar J, Emmelot-Vonk, Marielle H, Cremer, Olaf L, Vernooij, Lisette M, and Noordzij, Peter G

Published
2024

32. Cohort profile of BIGPROMISE: a perioperative biobank of a high-risk surgical population

Author

Infection & Immunity, Onderzoek, Sepsis and Inflammation, Medische Staf Intensive Care, Noordzij, Peter G., Ruven, Henk Jt, Reniers, Ted, Idema, Rene N., Thio, Maaike Sy, Cremer, Olaf L., Hollema, Nynke, Smit, Kyra N., Vernooij, Lisette M., Dijkstra, Ineke M., Rettig, Thijs Cd, Infection & Immunity, Onderzoek, Sepsis and Inflammation, Medische Staf Intensive Care, Noordzij, Peter G., Ruven, Henk Jt, Reniers, Ted, Idema, Rene N., Thio, Maaike Sy, Cremer, Olaf L., Hollema, Nynke, Smit, Kyra N., Vernooij, Lisette M., Dijkstra, Ineke M., and Rettig, Thijs Cd

Published
2024

33. Glycan-specific IgM is critical for human immunity to Staphylococcus aureus

Author

MMB Research line 1, Infection & Immunity, Sepsis and Inflammation, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectious Diseases, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, MMB Onderzoek en Onderwijs, Hendriks, Astrid, Kerkman, Priscilla F, Varkila, Meri R J, Haitsma Mulier, Jelle L G, Ali, Sara, Ten Doesschate, Thijs, van der Vaart, Thomas W, de Haas, Carla J C, Aerts, Piet C, Cremer, Olaf L, Bonten, Marc J M, Nizet, Victor, Liu, George Y, Codée, Jeroen D C, Rooijakkers, Suzan H M, van Strijp, Jos A G, van Sorge, Nina M, MMB Research line 1, Infection & Immunity, Sepsis and Inflammation, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectious Diseases, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, MMB Onderzoek en Onderwijs, Hendriks, Astrid, Kerkman, Priscilla F, Varkila, Meri R J, Haitsma Mulier, Jelle L G, Ali, Sara, Ten Doesschate, Thijs, van der Vaart, Thomas W, de Haas, Carla J C, Aerts, Piet C, Cremer, Olaf L, Bonten, Marc J M, Nizet, Victor, Liu, George Y, Codée, Jeroen D C, Rooijakkers, Suzan H M, van Strijp, Jos A G, and van Sorge, Nina M

Published
2024

34. The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia

Author

Sepsis and Inflammation, Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, Chouchane, Osoul, Schuurman, Alex R, Reijnders, Tom D Y, Peters-Sengers, Hessel, Butler, Joe M, Uhel, Fabrice, Schultz, Marcus J, Bonten, Marc J, Cremer, Olaf L, Calfee, Carolyn S, Matthay, Michael A, Langley, Raymond J, Alipanah-Lechner, Narges, Kingsmore, Stephen F, Rogers, Angela, Weeghel, Michel van, Vaz, Frédéric M, van der Poll, Tom, Sepsis and Inflammation, Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, Chouchane, Osoul, Schuurman, Alex R, Reijnders, Tom D Y, Peters-Sengers, Hessel, Butler, Joe M, Uhel, Fabrice, Schultz, Marcus J, Bonten, Marc J, Cremer, Olaf L, Calfee, Carolyn S, Matthay, Michael A, Langley, Raymond J, Alipanah-Lechner, Narges, Kingsmore, Stephen F, Rogers, Angela, Weeghel, Michel van, Vaz, Frédéric M, and van der Poll, Tom

Published
2024

35. Monocyte state 1 (MS1) cells in critically ill patients with sepsis or non-infectious conditions: association with disease course and host response

Author

Medische Staf Intensive Care, Infection & Immunity, Sepsis and Inflammation, Leite, Giuseppe G F, de Brabander, Justin, Michels, Erik H A, Butler, Joe M, Cremer, Olaf L, Scicluna, Brendon P, Sweeney, Timothy E, Reyes, Miguel, Salomao, Reinaldo, Peters-Sengers, Hessel, van der Poll, Tom, Medische Staf Intensive Care, Infection & Immunity, Sepsis and Inflammation, Leite, Giuseppe G F, de Brabander, Justin, Michels, Erik H A, Butler, Joe M, Cremer, Olaf L, Scicluna, Brendon P, Sweeney, Timothy E, Reyes, Miguel, Salomao, Reinaldo, Peters-Sengers, Hessel, and van der Poll, Tom

Published
2024

36. Biomarker patterns in patients with cardiogenic shock versus septic shock

Author

Medische Staf Intensive Care, Infection & Immunity, Peters, Elma J., Frydland, Martin S., Hassager, Christian, Bos, Lieuwe D.J., van Vught, Lonneke A., Cremer, Olaf L., Møller, Jacob E., van den Born, Bert Jan H., Vlaar, Alexander P.J., Henriques, Jose P.S., Medische Staf Intensive Care, Infection & Immunity, Peters, Elma J., Frydland, Martin S., Hassager, Christian, Bos, Lieuwe D.J., van Vught, Lonneke A., Cremer, Olaf L., Møller, Jacob E., van den Born, Bert Jan H., Vlaar, Alexander P.J., and Henriques, Jose P.S.

Published
2024

37. Examining pancreatic stone protein response in ICU-acquired bloodstream infections: a matched event analysis

Author

Infection & Immunity, Epi Infectieziekten Team 1, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Verlaan, Diede, Derde, Lennie P G, van der Poll, Tom, Bonten, Marc J M, Cremer, Olaf L, Infection & Immunity, Epi Infectieziekten Team 1, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectieziekten, Verlaan, Diede, Derde, Lennie P G, van der Poll, Tom, Bonten, Marc J M, and Cremer, Olaf L

Published
2024

38. Inflammatory subphenotypes previously identified in ARDS are associated with mortality at intensive care unit discharge: a secondary analysis of a prospective observational study

Author

Medische Staf Intensive Care, Infection & Immunity, Slim, Marleen A., van Amstel, Rombout B.E., Bos, Lieuwe D.J., Cremer, Olaf L., Wiersinga, W. Joost, van der Poll, Tom, van Vught, Lonneke A., Medische Staf Intensive Care, Infection & Immunity, Slim, Marleen A., van Amstel, Rombout B.E., Bos, Lieuwe D.J., Cremer, Olaf L., Wiersinga, W. Joost, van der Poll, Tom, and van Vught, Lonneke A.

Published
2024

40. Neuropsychiatric sequelae following extracorporeal membrane oxygenation in the intensive care unit

Author

Infection & Immunity, Sepsis and Inflammation, Epi Methoden Team 3, Medische Staf Intensive Care, Other research (not in main researchprogram), Pladet, Lara C A, Luijken, Kim, Donker, Dirk W, Cremer, Olaf L, Meuwese, Christiaan L, Infection & Immunity, Sepsis and Inflammation, Epi Methoden Team 3, Medische Staf Intensive Care, Other research (not in main researchprogram), Pladet, Lara C A, Luijken, Kim, Donker, Dirk W, Cremer, Olaf L, and Meuwese, Christiaan L

Published
2024

41. Two-step interpretable modeling of ICU-AIs

Author

Sub Mathematical Modeling, Mathematical Modeling, Lancia, Giacomo, Varkila, Meri, Cremer, Olaf L., Spitoni, Cristian, Sub Mathematical Modeling, Mathematical Modeling, Lancia, Giacomo, Varkila, Meri, Cremer, Olaf L., and Spitoni, Cristian

Published
2024

42. Predictors for extubation failure in COVID-19 patients using a machine learning approach

Author

Fleuren, Lucas M., Dam, Tariq A., Tonutti, Michele, de Bruin, Daan P., Lalisang, Robbert C. A., Gommers, Diederik, Cremer, Olaf L., Bosman, Rob J., Rigter, Sander, Wils, Evert-Jan, Frenzel, Tim, Dongelmans, Dave A., de Jong, Remko, Peters, Marco, Kamps, Marlijn J. A., Ramnarain, Dharmanand, Nowitzky, Ralph, Nooteboom, Fleur G. C. A., de Ruijter, Wouter, Urlings-Strop, Louise C., Smit, Ellen G. M., Mehagnoul-Schipper, D. Jannet, Dormans, Tom, de Jager, Cornelis P. C., Hendriks, Stefaan H. A., Achterberg, Sefanja, Oostdijk, Evelien, Reidinga, Auke C., Festen-Spanjer, Barbara, Brunnekreef, Gert B., Cornet, Alexander D., van den Tempel, Walter, Boelens, Age D., Koetsier, Peter, Lens, Judith, Faber, Harald J., Karakus, A., Entjes, Robert, de Jong, Paul, Rettig, Thijs C. D., Arbous, Sesmu, Vonk, Sebastiaan J. J., Fornasa, Mattia, Machado, Tomas, Houwert, Taco, Hovenkamp, Hidde, Noorduijn Londono, Roberto, Quintarelli, Davide, Scholtemeijer, Martijn G., de Beer, Aletta A., Cinà, Giovanni, Kantorik, Adam, de Ruijter, Tom, Herter, Willem E., Beudel, Martijn, Girbes, Armand R. J., Hoogendoorn, Mark, Thoral, Patrick J., and Elbers, Paul W. G.

Published
2021
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43. The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients

Author

Fleuren, Lucas M., Dam, Tariq A., Tonutti, Michele, de Bruin, Daan P., Lalisang, Robbert C. A., Gommers, Diederik, Cremer, Olaf L., Bosman, Rob J., Rigter, Sander, Wils, Evert-Jan, Frenzel, Tim, Dongelmans, Dave A., de Jong, Remko, Peters, Marco, Kamps, Marlijn J. A., Ramnarain, Dharmanand, Nowitzky, Ralph, Nooteboom, Fleur G. C. A., de Ruijter, Wouter, Urlings-Strop, Louise C., Smit, Ellen G. M., Mehagnoul-Schipper, D. Jannet, Dormans, Tom, de Jager, Cornelis P. C., Hendriks, Stefaan H. A., Achterberg, Sefanja, Oostdijk, Evelien, Reidinga, Auke C., Festen-Spanjer, Barbara, Brunnekreef, Gert B., Cornet, Alexander D., van den Tempel, Walter, Boelens, Age D., Koetsier, Peter, Lens, Judith, Faber, Harald J., Karakus, A., Entjes, Robert, de Jong, Paul, Rettig, Thijs C. D., Arbous, Sesmu, Vonk, Sebastiaan J. J., Fornasa, Mattia, Machado, Tomas, Houwert, Taco, Hovenkamp, Hidde, Noorduijn-Londono, Roberto, Quintarelli, Davide, Scholtemeijer, Martijn G., de Beer, Aletta A., Cina, Giovanni, Beudel, Martijn, Herter, Willem E., Girbes, Armand R. J., Hoogendoorn, Mark, Thoral, Patrick J., and Elbers, Paul W. G.

Published
2021
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47. The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia

Author

Chouchane, Osoul, primary, Schuurman, Alex R., additional, Reijnders, Tom D. Y., additional, Peters-Sengers, Hessel, additional, Butler, Joe M, additional, Uhel, Fabrice, additional, Schultz, Marcus J, additional, Bonten, Marc J., additional, Cremer, Olaf L, additional, Calfee, Carolyn S, additional, Matthay, Michael A., additional, Langley, Raymond J, additional, Alipanah-Lechner, Narges, additional, Kingsmore, Stephen F, additional, Rogers, Angela, additional, Weeghel, Michel van, additional, Vaz, Frédéric M., additional, and van der Poll, Tom, additional

Published
2024
Full Text
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