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107 results on '"Creemers, John W.M."'

3. Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function

Author

Rosier, Karen, McDevitt, Molly T., Smet, Joél, Floyd, Brendan J., Verschoore, Maxime, Marcaida, Maria J., Bingman, Craig A., Lemmens, Irma, Dal Peraro, Matteo, Tavernier, Jan, Cravatt, Benjamin F., Gounko, Natalia V., Vints, Katlijn, Monnens, Yenthe, Bhalla, Kritika, Aerts, Laetitia, Rashan, Edrees H., Vanlander, Arnaud V., Van Coster, Rudy, Régal, Luc, Pagliarini, David J., and Creemers, John W.M.

Published
2021
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4. Missense mutations in CMS22 patients reveal that PREPL has both enzymatic and non-enzymatic functions

Author

Monnens, Yenthe, primary, Theodoropoulou, Anastasia, additional, Rosier, Karen, additional, Bhalla, Kritika, additional, Mahy, Alexia, additional, Vanhoutte, Roeland, additional, Meulemans, Sandra, additional, Cavani, Edoardo, additional, Antanasijevic, Aleksandar, additional, Lemmens, Irma, additional, Lee, Jennifer A., additional, Spellicy, Catherin J., additional, Schroer, Richard J., additional, Masalli, Richardo A., additional, Laverty, Chamindra G., additional, Agostinis, Patrizia, additional, Pagliarini, David, additional, Verhelst, Steven, additional, Marcaida, Maria J., additional, Rochtus, Anne, additional, Dal Peraro, Matteo, additional, and Creemers, John W.M., additional

Published
2023
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6. Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation

Author

Courbon, Guillaume, primary, Thomas, Jane J., additional, Martinez Calle, Marta, additional, Wang, Xueyan, additional, Spindler, Jadeah, additional, Von Drasek, John, additional, Hunt-Tobey, Bridget, additional, Mehta, Rupal, additional, Isakova, Tamara, additional, Chang, Wenhan, additional, Creemers, John W.M., additional, Ji, Peng, additional, Martin, Aline, additional, and David, Valentin, additional

Published
2023
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7. Proprotein convertase furin regulates osteocalcin and bone endocrine function

Author

Al Rifai, Omar, Chow, Jacqueline, Lacombe, Julie, Julien, Catherine, Faubert, Denis, Susan-Resiga, Delia, Essalmani, Rachid, Creemers, John W.M., Seidah, Nabil G., and Ferron, Mathieu

Subjects
Osteoblasts -- Research, Glucose tolerance test -- Usage, Base sequence -- Usage, Peptide hormones -- Research, Health care industry
Abstract

Osteocalcin (OCN) is an osteoblast-derived hormone that increases energy expenditure, insulin sensitivity, insulin secretion, and glucose tolerance. The cDNA sequence of OCN predicts that, like many other peptide hormones, OCN is first synthesized as a prohormone (pro-OCN). The importance of pro-OCN maturation in regulating OCN and the identity of the endopeptidase responsible for pro-OCN cleavage in osteoblasts are still unknown. Here, we show that the proprotein convertase furin is responsible for pro-OCN maturation in vitro and in vivo. Using pharmacological and genetic experiments, we also determined that furin-mediated pro-OCN cleavage occurred independently of its [gamma]- carboxylation, a posttranslational modification that is known to hamper OCN endocrine action. However, because pro-OCN is not efficiently decarboxylated and activated during bone resorption, inactivation of furin in osteoblasts in mice resulted in decreased circulating levels of undercarboxylated OCN, impaired glucose tolerance, and reduced energy expenditure. Furthermore, we show that Furin deletion in osteoblasts reduced appetite, a function not modulated by OCN, thus suggesting that osteoblasts may secrete additional hormones that regulate different aspects of energy metabolism. Accordingly, the metabolic defects of the mice lacking furin in osteoblasts became more apparent under pair-feeding conditions. These findings identify furin as an important regulator of bone endocrine function., Introduction It has been recently established that bone acts as an endocrine organ that secretes at least 3 hormones: fibroblast growth factor 23 (FGF23), lipocalin 2 (LCN2), and osteocalcin (OCN). [...]

Published
2017
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9. Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression

Author

Brouwers, Bas, de Faudeur, Geoffroy, Osipovich, Anna B., Goyvaerts, Lotte, Lemaire, Katleen, Boesmans, Leen, Cauwelier, Elisa J.G., Granvik, Mikaela, Pruniau, Vincent P.E.G., Van Lommel, Leentje, Van Schoors, Jolien, Stancill, Jennifer S., Smolders, Ilse, Goffin, Vincent, Binart, Nadine, in’t Veld, Peter, Declercq, Jeroen, Magnuson, Mark A., Creemers, John W.M., Schuit, Frans, and Schraenen, Anica

Published
2014
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10. Whole-Exome Sequencing of 677 Unrelated Aneurysm Patients Identifies Multiple Rare Variants of the Proprotein Convertase Furin Causing Impaired TGFB Signaling

Author

IJpma, Arne, additional, He, Zongsheng, additional, Vreeken, Dianne, additional, Heijsman, Daphne, additional, Verhagen, Hence J.M., additional, De Bruijn, Jorg, additional, Raa, Sander Ten, additional, Bruggenwirth, Hennie T., additional, Roos-Hesselink, Jolien W., additional, Bekkers, Jos A., additional, Huylebroeck, Danny, additional, Creemers, John W.M., additional, and Majoor-Krakauer, Danielle, additional

Published
2022
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14. Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate

Author

Louagie, Els, Taylor, Neil A., Flamez, Daisy, Roebroek, Anton J.M., Bright, Nicholas A., Meulemans, Sandra, Quintens, Roel, Herrera, Pedro L., Schuit, Frans, Van de Ven, Wim J.M., and Creemers, John W.M.

Subjects
Insulin -- Properties, Islands of Langerhans -- Properties, Proteases -- Properties, Proteins -- Properties, Pancreas -- Research, Science and technology
Abstract

Furin is a proprotein convertase which activates a variety of regulatory proteins in the constitutive exocytic and endocytic pathway. The effect of genetic ablation of fur was studied in the endocrine pancreas to define its physiological function in the regulated secretory pathway. Pdx1-Cre/IoxP furin KO mice show decreased secretion of insulin and impaired processing of known PC2 substrates like proPC2 and proinsulin II. Both secretion and PC2 activity depend on granule acidification, which was demonstrated to be significantly decreased in furin-deficient [beta] cells by using the acidotrophic agent 3-(2,4-dinitroanilino)-3'amino-N-methyldipropylamine (DAMP). Ac45, an accessory subunit of the proton pump V-ATPase, was investigated as a candidate substrate. Ac45 is highly expressed in islets of Langerhans and furin was able to cleave Ac45 ex vivo. Furthermore, the exact cleavage site was determined. In addition, reduced regulated secretion and proinsulin II processing could be obtained in the insulinoma cell line [beta]TC3 by downregulation of either furin or Ac45. Together, these data establish an important role for furin in regulated secretion, particularly in intragranular acidification most likely due to impaired processing of Ac45. endoprotease | insulin | islets of Langerhans | proton pump | proprotein convertase

Published
2008

15. Loss of Furin in β cells Induces an mTORC1-ATF4 Anabolic Pathway that Leads to β cell Dysfunction

Author

Brouwers, Bas, primary, Coppola, Ilaria, primary, Vints, Katlijn, primary, Dislich, Bastian, primary, Jouvet, Nathalie, primary, Lommel, Leentje Van, primary, Segers, Charlotte, primary, Gounko, Natalia V., primary, Thorrez, Lieven, primary, Schuit, Frans, primary, Lichtenthaler, Stefan F., primary, Estall, Jennifer L., primary, Declercq, Jeroen, primary, Ramos-Molina, Bruno, primary, and Creemers, John W.M., primary

Published
2020
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16. Loss of Furin in β cells Induces an mTORC1-ATF4 Anabolic Pathway that Leads to β cell Dysfunction

Author

Admin, Ada, primary, Brouwers, Bas, primary, Coppola, Ilaria, primary, Vints, Katlijn, primary, Dislich, Bastian, primary, Jouvet, Nathalie, primary, Lommel, Leentje Van, primary, Segers, Charlotte, primary, Gounko, Natalia V., primary, Thorrez, Lieven, primary, Schuit, Frans, primary, Lichtenthaler, Stefan F., primary, Estall, Jennifer L., primary, Declercq, Jeroen, primary, Ramos-Molina, Bruno, primary, and Creemers, John W.M., primary

Published
2020
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17. Contributors

Author

Abbott, Catherine Anne, primary, Abraham, Carmela R., additional, Adachi, Hideki, additional, Adachi, Osao, additional, Adam, Zach, additional, Adams, Michael W.W., additional, Adang, Michael J., additional, Adham, Ibrahim M., additional, Aducci, Patrizia, additional, Agard, David A., additional, Agranovsky, Alexey A., additional, Akamatsu, Tetsuya, additional, Akiyama, Yoshinori, additional, Albrechtsen, Reidar, additional, Alejo, Alí, additional, Amberg, Sean M., additional, Amerik, Alexander Y., additional, Amparyup, Piti, additional, Andrade, Felipe, additional, Andrés, Germán, additional, Andrews, Daniel M., additional, Andrews, Robert K., additional, Antalis, Toni M., additional, Anthony, Colin S., additional, Aoki, Naoya, additional, Apte, Suneel S., additional, Arima, Kazunari, additional, Arlaud, Gérard, additional, Arni, Raghuvir Krishnaswamy, additional, Arnoux, Pascal, additional, Aronson, Nathan N., additional, Arthur, Michel, additional, Asano, Yasuhisa, additional, Ascenzi, Paolo, additional, Assakura, Marina T., additional, Auld, David S., additional, Ávila, Veridiana de Melo Rodrigues, additional, Avilés, Francesc X., additional, Awad, William M., additional, Bachhawat, Anand K., additional, Bai, Shan, additional, Baird, Teaster T., additional, Bajaj, S. Paul, additional, Baker, Susan C., additional, Banbula, Agnieszka, additional, Barrett, Alan J., additional, Barrowman, Jemima, additional, Bartlett, John D., additional, Bartsch, Jörg W., additional, Baschuk, Nikola, additional, Baskova, Isolda P., additional, Batra, Jyotsna, additional, Bauer, Karl, additional, Baumann, Ulrich, additional, Baumeister, Wolfgang, additional, Bauvois, Cédric, additional, Bayés, Alex, additional, Beauvais, Anne, additional, Becker-Pauly, Christoph, additional, Begley, Tadhg P., additional, Békés, Miklós, additional, Belas, Robert, additional, Beleford, Daniah, additional, Beppu, Teruhiko, additional, Bergmann, Ernst M., additional, Bernard, Bruno A., additional, Bernard, Dominique, additional, Berndt, Michael C., additional, Berruti, Giovanna, additional, Berry, Colin, additional, Bertenshaw, Greg P., additional, Betzel, Christian, additional, Bhaskarla, Chetana, additional, Bhosale, Manoj, additional, Bierbaum, Gabriele, additional, Bjarnason Jón, B., additional, Blaber, Michael, additional, Blackman, Michael J., additional, Blinkovsky, Alexander, additional, Boeke, Jef D., additional, Bogyo, Matthew, additional, Bohn, Stefan, additional, Boileau, Guy, additional, Boland, Mike, additional, Bolken, Tové C., additional, Bond, Judith S., additional, Bondeson, Jan, additional, Bordallo, Javier, additional, Borelli, Claudia, additional, Botelho, Tiago O., additional, Bott, Richard R., additional, Bourne, David G., additional, Bovenschen, Niels, additional, Bradshaw, Ralph A., additional, Breddam, Klaus, additional, Brew, Keith, additional, Brindley, Paul J., additional, Brinkman, Diane L., additional, Britton, Collette, additional, Broadbent, Jeff R., additional, Broadhurst, Anne, additional, Brómme, Dieter, additional, Broom, Murray, additional, Brown, Jeremy S., additional, Brown, Mark A., additional, Bruchhaus, Iris, additional, Burleigh, Barbara A., additional, Burns, Kristin E., additional, Burrows, James F., additional, Butler, Michael J., additional, Buttle, David J., additional, Byrd, Chelsea M., additional, Byun, Tony, additional, Cadel, Sandrine, additional, Caffrey, Conor R., additional, Cal, Santiago, additional, Caldentey, Javier, additional, Candela, Thomas, additional, Capasso, Clemente, additional, Capriogilio, Daniel R., additional, Carginale, Vincenzo, additional, Carmona, Adriana Karaoglanovic, additional, Carruthers, Vern B., additional, Castellino, Francis J., additional, Catanese, Joseph J., additional, Caterson, Bruce, additional, Caughey, George H., additional, Cawley, Naimh X., additional, Cawston, Tim E., additional, Cazzulo, Juan José, additional, Chai, Jijie, additional, Chai, Karl X., additional, Chaim, Olga Meiri, additional, Chang, L.S., additional, Chao, Julie, additional, Chapot-Chartier, Marie-Pierre, additional, Charli, Jean-Louis, additional, Charlier, Paulette, additional, Chave, Karen J., additional, Chen, Jian-Min, additional, Chen, Jinq-May, additional, Chen, Li-Mei, additional, Chen, Ya-Wen, additional, Chen, Yu-Yen, additional, Chevrier, Bernard, additional, Chich, Jean-François, additional, Chien, Jeremy, additional, Chimalapati, Suneeta, additional, Cho, Ki Joon, additional, Choi, Kwan Yong, additional, Chuang, Woei-Jer, additional, Chung, Chin Ha, additional, Chung, Ivy Yeuk Wah, additional, Clamagirand, Christine, additional, Clark, Ian M., additional, Clarke, Adrian K., additional, Clarke, Nicola E., additional, Clarke, Steven Gerard, additional, Clauziat, Philippe, additional, Clements, Judith A., additional, Coffinier, Catherine, additional, Cohen, Paul, additional, Colige, Alain, additional, Collignon, Anne, additional, Colloms, Sean D., additional, Conzelmann, Andreas, additional, Coombs, Graham H., additional, Cooney, Jakki C., additional, Cooper, Jonathan B., additional, Cooper, Max D., additional, Copeland, Nikki A., additional, Cottrell, Graeme S., additional, Coyle, Joseph T., additional, Craik, Charles S., additional, Creemers, John W.M., additional, Cretu, Daniela, additional, Croce, Jenifer, additional, Cross, Keith J., additional, Cueva, Rosario, additional, Cui, Sheng, additional, Cunha, Luis, additional, Cutting, Simon, additional, d’Enfert, Christophe, additional, D’Orchymont, Hugues, additional, Dahlbäck, Björn, additional, Dai, Shujia, additional, Dalbey, Ross E., additional, Dalton, John P., additional, Dando, Pam M., additional, Daniel, R.M., additional, Danilov, Sergei M., additional, Davies, Donna E., additional, De Araujo, Heloisa S., additional, De los Santos, Teresa, additional, de Luca, Viviana, additional, De Meester, Ingrid, additional, de Oliveira, Ana Karina, additional, de Oliveira, Eduardo Brandt, additional, De Oliveira, Pedro Lagerblad, additional, de Vos, Sarah, additional, Declercq, Jeroen, additional, Declercq, Wim, additional, Deghmane, Ala-Eddine, additional, Dekker, Niek, additional, Del Prete, Sonia, additional, Del Rosal, Marina, additional, Delmas, Bernard, additional, DeLotto, Robert, additional, Demidyuk, Ilya V., additional, Denison, Mark R., additional, Deussing, Jan M., additional, Devi, Lakshmi A., additional, Diamandis, Eleftherios P., additional, Diaz, Isabel, additional, Díaz-Perales, Araceli, additional, Dijkstra, Bauke W., additional, Ding, Yan, additional, Dixon, Jack E., additional, Dodt, Johannes, additional, Dokland, Terje, additional, Dolenc, Iztok, additional, Dong, Ningzheng, additional, Dong, Tran Cat, additional, Dong, Ying, additional, Dongre, Mitesh, additional, Donovan, Mark, additional, Dore, Timothy M., additional, Dorstyn, Loretta, additional, Dou, Hong, additional, Dou, Zhicheng, additional, Dougall, Annette M., additional, Drag, Marcin, additional, Dudley, Edward G., additional, Dunn, Ben M., additional, Dupuy, Bruno, additional, Duque-Magalhāes, Maria Conceicāo, additional, Durá, M. Asunción, additional, Eeckhout, Yves, additional, Eijsink, Vincent, additional, Eisen, Arthur Z., additional, Eissa, Azza, additional, Eklund, Sandra, additional, Eletr, Ziad M., additional, Ellis, Vincent, additional, Engel, Wolfgang, additional, Erdös, Ervin G., additional, Escalante, Teresa, additional, Estell, David A., additional, Etscheid, Michael, additional, Evans, Herbert J., additional, Everett, Roger D., additional, Faesen, Alex C., additional, Fahrenholz, Falk, additional, Fanjul-Fernández, Miriam, additional, Farady, Christopher J., additional, Feller, Georges, additional, Feng, Hong, additional, Fenster, Kurt M., additional, Férec, Claude, additional, Ferrari, Silvia, additional, Fingleton, Barbara, additional, Fisher, Jed F., additional, Fives-Taylor, Paula M., additional, Fong, Loren G., additional, Forneris, F., additional, Forster, Brian M., additional, Forster, Friedrich, additional, Foster, Simon J., additional, Foulon, Thierry, additional, Foundling, Stephen I., additional, Fox, Jay William, additional, Franzetti, Bruno, additional, Frasch, Alejandra P., additional, Freeze, Hudson H., additional, Frère, Jean-Marie, additional, Frey, Teryl K., additional, Fricke, Beate, additional, Fricker, Lloyd D., additional, Fridman, Rafael, additional, Froelich, Christopher J., additional, Fröhlich, Camilla, additional, Fu, Hsueh-Liang, additional, Fuhrmann, Cynthia N., additional, Fujimura, Satoshi, additional, Fujiwara, Hiroshi, additional, Fukushima, Jun, additional, Fukuyama, Keiichi, additional, Fuller, Robert S., additional, Fusek, Martin, additional, Gaboriaud, Christine, additional, Gache, Christian, additional, Gakh, Oleksandr, additional, Gal, Peter, additional, Gao, Junjun, additional, García-Sastre, Adolfo, additional, Gardiner, Donald L., additional, Gatehouse, John A., additional, Gaucher, G.M., additional, Gauthier, Francis, additional, Ghuysen, Jean-Marie, additional, Gibson, Wade, additional, Gillies, Jennifer, additional, Glaser, Elzbieta, additional, Glaser, Fabian, additional, Glickman, Michael H., additional, Goettig, Peter, additional, Goffin, Colette, additional, Gohda, Eiichi, additional, Goldberg, Alfred L., additional, Goldberg, Daniel E., additional, Goldberg, Gregory I., additional, Goldfarb, Nathan E., additional, Gomis-Rüth, F. Xavier, additional, Gopal, B., additional, Gorbalenya, Alexander E., additional, Gordon, Stuart G., additional, Gorrell, Mark D., additional, Götz, Friedrich, additional, Goulas, Theodoros, additional, Gouzy-Darmon, Cécile, additional, Govind, K., additional, Gráf, Lászlo, additional, Granados, Robert R., additional, Gräwert, Melissa Ann, additional, Gray, Douglas A., additional, Graycar, Thomas P., additional, Green, Jonathan A., additional, Gremski, Luiza Helena, additional, Groll, Michael, additional, Gromova, Tania Yu, additional, Gros, P., additional, Grubman, Marvin J., additional, Grunden, Amy M., additional, Gudmundsdóttir, Ágústa, additional, Guinand, Micheline, additional, Gully, Djamel, additional, Gustchina, Alla, additional, Gutiérrez, José María, additional, Ha, Byung Hak, additional, Haeggström, Jesper Z., additional, Hageman, James H., additional, Haiko, Johanna, additional, Hailfinger, Stephan, additional, Haitchi, Hans Michael, additional, Han, Ji Seon, additional, Hanquez, Chantal, additional, Harada, Minoru, additional, Hara-Nishimura, Ikuko, additional, Harboe, Marianne, additional, Härd, Torleif, additional, Harris, David A., additional, Hassiepen, Ulrich, additional, Hata, Shoji, additional, Hattori, Akira, additional, He, Rong-Qiao, additional, Heck, Albert J.R., additional, Hendricks, Dirk F., additional, Henrich, Bernhard, additional, Henriet, Patrick, additional, Hernández-Arana, Andrés, additional, Herrera-Camacho, Irma, additional, Heussipp, Gerhard, additional, Hibino, Toshihiko, additional, Hicks, P.M., additional, Hillman, Bradley I., additional, Hiraoka, B. Yukihiro, additional, Hiratake, Jun, additional, Hizukuri, Yohei, additional, Ho, Heng-Chien, additional, Hoa, Ngo Thi, additional, Hochstrasser, Mark, additional, Hodge, Kathryn M., additional, Hofmann, Theo, additional, Hohn, Thomas, additional, Hoidal, John R., additional, Höltje, Joachim-Volker, additional, Homma, Koichi J., additional, Honek, John F., additional, Hook, Vivian Y.H., additional, Hooper, John D., additional, Hooper, Nigel M., additional, Hosoi, Kazuo, additional, Howe, Christopher J., additional, Hruby, Dennis E., additional, Hseih, James J.-D., additional, Hsu, Chun-Chieh, additional, Huang, Tony T., additional, Huang, Tur-Fu, additional, Huet, Yoann, additional, Hughes, Clare, additional, Hugonnet, Jean-Emmanuel, additional, Huston, Adrienne L., additional, Ibrahim-Granet, Oumaïma, additional, Ichishima, Eiji, additional, Ikehara, Yukio, additional, Inagami, Tadashi, additional, Ingram, Jessica, additional, Isaac, R.E., additional, Isaya, Grazia, additional, Isaza, Clara E., additional, Ishii, Shin-ichi, additional, Isnard, Amandine, additional, Ito, Kiyoshi, additional, Ito, Koreaki, additional, Itoh, Yoshifumi, additional, Iturrioz, Xavier, additional, Iwanaga, Sadaaki, additional, Jack, Ralph W., additional, Jackson, Mel C., additional, James, Michael N.G., additional, Janata, Jiří, additional, Janoir, Claire, additional, Janska, Hanna, additional, Jarrell, Ken F., additional, Jaskolski, Mariusz, additional, Jaswal, Sheila S., additional, Jean, Ying Y., additional, Jenne, Dieter E., additional, Jeon, Young Joo, additional, Jiang, Ping, additional, Johnson, John E., additional, Johnson, Michael D., additional, Johnston, James A., additional, Jones, Amanda, additional, Jones, Elizabeth W., additional, Joudiou, Carine, additional, Juliano, Luiz, additional, Jung, Hea-Jin, additional, Jupp, Ray, additional, Kagawa, Todd F., additional, Kalbacher, Hubert, additional, Kamata, Yayoi, additional, Kaminogawa, Shuichi, additional, Kamio, Yoshiyuki, additional, Kaneda, Makoto, additional, Kang, Sung Gyun, additional, Kang, Sung Hwan, additional, Kania, Mary, additional, Kantyka, Tomasz, additional, Kanzawa, Nobuyuki, additional, Karim, Abdulkarim Y., additional, Kasumi, Takafumi, additional, Kataoka, Hiroaki, additional, Kaur, Hardeep, additional, Kawabata, Shun-Ichiro, additional, Kawaguchi, Mari, additional, Kay, John, additional, Kaynar, Murat, additional, Keiler, Kenneth C., additional, Kelly, R.M., additional, Kenton, Nathaniel T., additional, Kerr, Michael A., additional, Kersse, Kristof, additional, Kervinen, Jukka, additional, Kessler, Benedikt M., additional, Kessler, Efrat, additional, Khoronen, Timo K., additional, Kidd, Simon, additional, Kikkert, Marjolein, additional, Kilian, Mogens, additional, Kim, Do-Hyung, additional, Kim, Doyoun, additional, Kim, Eunice EunKyeong, additional, Kim, In Seop, additional, Kim, Jung-Gun, additional, Kim, Kyeong Kyu, additional, Kim, Kyung Hyun, additional, Kimber, Matthew S., additional, Kimura, Yukio, additional, Kirschke, Heidrun, additional, Kiso, Yoshiaki, additional, Kleanthous, Colin, additional, Klein, Jürgen R., additional, Klemba, Michael, additional, Kmiec, Beata, additional, Kobayashi, Hideyuki, additional, Kodama, Hiroyuki, additional, Koelsch, Gerald, additional, Kok, Jan, additional, Kolattukody, P.E., additional, Kolb, Fabrice A., additional, Kolmar, Harald, additional, Komori, Yumiko, additional, Konvalinka, Jan, additional, Korkmaz, Brice, additional, Kostrov, Sergey V., additional, Kräusslich, Hans-Georg, additional, Krczal, Gabi, additional, Kress, Lawrence F., additional, Kristjánsson, Magnüs Már, additional, Kučera, Tomáš, additional, Kukday, Sayali S., additional, Kumagai, Hidehiko, additional, Kumar, Sharad, additional, Kumarasiri, Malika, additional, Kumazaki, Takashi, additional, Kümmerer, Beate M., additional, Kuno, Kouji, additional, Kurkinen, Markku, additional, Kutejová, Eva, additional, Kveiborg, Marie, additional, Kwarciak, Agnieszka, additional, Laakkonen, Liisa, additional, Labrou, Nikolaos E., additional, Laing, Gavin D., additional, Lamppa, Gayle, additional, Langer, Thomas, additional, Laursen, Richard A., additional, Lawrenson, Richard A., additional, Layne, Matthew D., additional, Le Bonniec, Bernard F., additional, Leal, María C., additional, Lechan, Ronald M., additional, Lee, David H., additional, Lee, Irene, additional, Lee, Jae, additional, Lee, Kye Joon, additional, Lee, Soohee, additional, Lei, Xiaobo, additional, Leis, Jonathan, additional, LeMosy, Ellen K., additional, Lepage, Thierry, additional, Leppla, Stephen H., additional, Lesner, Adam, additional, Lessard, Ivan A.D., additional, Lhomond, Guy, additional, Li, Huilin, additional, Li, Shu-Ming, additional, Li, Weiguo, additional, Liao, Ta-Hsiu, additional, Liddington, Robert C., additional, Lieber, Toby, additional, Lijnen, H.R., additional, Lima, Christopher D., additional, Lin, Chen-Yong, additional, Lin, Gang, additional, Lin, Ming T., additional, Lin, Xinli, additional, Lin, Yee-Shin, additional, Lindsay, L.L., additional, Lipscomb, William N., additional, Little, John W., additional, Liu, Ching-Chuan, additional, Liu, Chuan-ju, additional, Lively, Mark O., additional, Livnat-Levanon, Nurit, additional, Ljungdahl, Per O., additional, Llorens-Cortes, Catherine, additional, Lobel, Peter, additional, Loh, Y. Peng, additional, Lohi, Jouko, additional, Lomonossoff, G.P., additional, Looze, Yvan, additional, López-Otin, Carlos, additional, Lopez-Quezada, Landys, additional, Loukas, Alex, additional, Lu, Long-Sheng, additional, Lundwall, Áke, additional, Luo, Liu-Ying, additional, Lupas, Andrei, additional, Luthe, Dawn S., additional, Lynch, Nicholas J., additional, Lyons, Peter J., additional, MacKay, Vivian L., additional, Macleod, Jesica M. Levingston, additional, Magdolen, Viktor, additional, Mainardi, Jean-Luc, additional, Mäkinen, Kauko K., additional, Mallari, Jeremy P., additional, Manandhar, Surya P., additional, Mandelbaum, Fajga R., additional, Manicone, Anne M., additional, Mansfeld, Johanna, additional, Marcotrigiano, Joseph, additional, Mares, Michael, additional, Marfany, Gemma, additional, Markland, Francis S., additional, Marokházi, Judith, additional, Marquis, Hélène, additional, Marr, Robert A., additional, Martegani, Enzo, additional, Martin, Erik W., additional, Martinez, Manuel, additional, Martins, L. Miguel, additional, Maruyama, Masato, additional, Maruyama, Masugi, additional, Maruyama, Sususmu, additional, Masaki, Takeharu, additional, Massoumi, Ramin, additional, Mathew, Rency T., additional, Matrisian, Lynn M., additional, Matsuda, Yoshihiro, additional, Matsushita, Osamu, additional, Matuschek, Marco, additional, Matušková, Anna, additional, Matúz, Krisztina, additional, Mauch, Cornelia, additional, Maurizi, Michael R., additional, Mayr, Lorenz M., additional, McCafferty, Dewey G., additional, McDonald, J. Ken, additional, McKerrow, James H., additional, McMillan, David, additional, Mecham, Robert P., additional, Mehta, Darshini P., additional, Meisinger, Chris, additional, Mellors, Alan, additional, Melton, Roger G., additional, Melvin, Jeffrey A., additional, Ménard, Robert, additional, Menéndez-Arias, Luis, additional, Menezes, Milene C., additional, Mesecar, Andrew, additional, Mesnage, Stéphane, additional, Meyer, Diane H., additional, Meyers, Gregor, additional, Michaelis, Susan, additional, Michalska, Karolina, additional, Mielicki, Wojciech P., additional, Mierau, Igor, additional, Mikoulinskaia, Galina V., additional, Miller, Charles G., additional, Miller, Lydia K., additional, Mills, John, additional, Mills, Kenneth V., additional, Min, Jinrong, additional, Mistou, Michel-Yves, additional, Misumi, Yoshio, additional, Miyoshi, Shin-ichi, additional, Mizutani, Shigehiko, additional, Mobashery, Shahriar, additional, Mochizuki, Satsuki, additional, Mock, William L., additional, Möhrlen, Frank, additional, Moiré, Nathalie, additional, Monahan, Paul E., additional, Moncada-Pazos, Angela, additional, Monnet, Véronique, additional, Monod, Michel, additional, Montecucco, Cesare, additional, Morelli, Laura, additional, Mori, Sumiko, additional, Morita, Takashi, additional, Morrissey, James H., additional, Morse, Richard J., additional, Mort, John S., additional, Mortensen, Uffe H., additional, Morty, Rory E., additional, Moss, Joel, additional, Motoshima, Hidemasa, additional, Mottram, Jeremy C., additional, Moura-da-Silva, Ana M., additional, Mudgett, Mary Beth, additional, Mundt, Egbert, additional, Murakami, Kazuo, additional, Murakami, Mario Tyago, additional, MurakamiMurofoshi, Kimiko, additional, Murao, Sawao, additional, Murphy, Gillian, additional, Murthy, M.R.N., additional, Muta, Tatsushi, additional, Myburgh, Elmarie, additional, Mzhavia, Nino, additional, Nabi, A.H.M. Nurun, additional, Nagase, Hideaki, additional, Nagle, Michael W., additional, Nägler, Dorit K., additional, Naik, Rajesh R., additional, Nair, Divya B., additional, Nakai, Toshiki, additional, Nakajima, Yoshitaka, additional, Nakamura, Yukio, additional, Nakatogawa, Hitoshi, additional, Nakayama, Toru, additional, Nalivaeva, Natalia N., additional, Nandi, Dipankar, additional, Nascimento-Silva, Maria Clara Leal, additional, Nasmyth, Kim, additional, Nathan, Carl F., additional, Navarro-García, Fernando, additional, Naves, Dayane Lorena, additional, Nedialkova, Danny D., additional, Neuman, Keir C., additional, Nguyen, Jeffrey-Tri, additional, Nguyen, Ky-Anh, additional, Niemirowicz, Gabriela T., additional, Nikai, Toshiaki, additional, Nishi, Eiichiro, additional, Nishii, Wataru, additional, Nishiyama, Makoto, additional, Nishiyama, Yasuhiro, additional, Noda, Masatoshi, additional, Nomura, Seiji, additional, Norioka, Shigemi, additional, Nsangou, Desire M.M., additional, O’Brien, Amornrat, additional, O’Connor, Michael B., additional, Oda, Kohei, additional, Odinokova, Irina V., additional, Oetjen, Joyce, additional, Ogura, Teru, additional, Ohman, Dennis E, additional, Ohsumi, Yoshinori, additional, Ojha, Mukti, additional, Okabe, Akinobu, additional, Okada, Yasunori, additional, Okamoto, Keinosuke, additional, Okuda, Kenji, additional, Okumura, Nobuaki, additional, Okuno, Takashi, additional, Oleson, Kjeld, additional, Oliveira de Giuseppe, Priscila, additional, Olivier, Martin, additional, Ono, Yasuko, additional, Oroszlan, Stephen, additional, Ota, Nobuyuki, additional, Ovadia, Michael, additional, O-Wang, Jiyang, additional, Oxvig, Claus, additional, Packer, Jeremy C.L., additional, Padilla-López, Sergio, additional, Paetzel, Mark, additional, Page, Michael J., additional, Page-McCaw, Andrea, additional, Paine, Mark J.I., additional, Park, Byoung Chul, additional, Park, Eunyong, additional, Park, John E., additional, Park, Pyong Woo, additional, Park, Sung Goo, additional, Parkin, Kirk L., additional, Parks, William C, additional, Paschoalin, Thaysa, additional, Pastore, Annalisa, additional, Patananan, Alexander Nikolich, additional, Paul, Sudhir, additional, Paulson, Henry L., additional, Pawel-Rammingen, Ulrich von, additional, Pearce, David A., additional, Pearson, Mark S., additional, Pei, Duanqing, additional, Pejler, Gunnar, additional, Pemberton, Alan D., additional, Peng, Jianhao, additional, Pernier, Julien, additional, Peters, Jan-Michael, additional, Pfirrmann, Thorsten, additional, Pham, Viet-Laï, additional, Pichová, Iva, additional, Pickering, Darren, additional, Piesse, Christophe, additional, Pignol, David, additional, Pike, Robert N., additional, Pinck, Lothaire, additional, Pirkle, Hubert, additional, Pitot, Henry C., additional, Plaut, Andrew G., additional, Ploegh, Hidde, additional, Polgár, László, additional, Porter, Corrine, additional, Postina, Rolf, additional, Potempa, Jan, additional, Poulsen, Knud, additional, Power, Scott D., additional, Pratt, Rex. F., additional, Prehna, Gerd, additional, Prévost, Gilles, additional, Pshezhetsky, Alexey V., additional, Qasim, Mohammad A., additional, Qian, Feng, additional, Qiu, Jiazhou, additional, Quesada, Víctor, additional, Radisky, Evette S., additional, Rader, Stephen D., additional, Raman, Kavita, additional, Ramsay, Andrew J., additional, Rancourt, Derrick E., additional, Ranjit, Najju, additional, Rao, Narayanam V., additional, Ratia, Kiira, additional, Rawlings, Neil D., additional, Rawson, Robert B., additional, Reddy, Vijay, additional, Redman, Colvin M., additional, Regonesi, Maria Elena, additional, Reichert, Andreas S., additional, Reichl, Antonia P., additional, Remaut, Han, additional, Remington, S. James, additional, Renatus, Martin, additional, Reverter, David, additional, Reynolds, Eric C., additional, Rholam, Mohamed, additional, Rice, Charles M., additional, Ridky, Todd W., additional, Riezman, Howard, additional, Rijken, D.C., additional, Rio, Marie-Christine, additional, Ritchie, Alison, additional, Robert-Baudouy, Janine, additional, Robinson, Mark W., additional, Robinson, Michael, additional, Rodriguez-Romero, Adela, additional, Rodriques, Renata Santos, additional, Rogers, John C., additional, Rojas, Camilo, additional, Romesberg, Floyd E., additional, Roper, David J., additional, Rosas-Murrieta, Nora, additional, Rose, A.M., additional, Rosenthal, Philip J., additional, Rosing, J., additional, Rossetto, Ornella, additional, Rossi, Véronique, additional, Roth, Richard A., additional, Rottensteiner, Hanspeter, additional, Rowan, Andrew D., additional, Rozanov, Mikhail, additional, Rucavado, Alexandra, additional, Ruecker, Andrea, additional, Rul, Françoise, additional, Rümenapf, Till, additional, Russo, Ilaria, additional, Ryan, Martin D., additional, Sacco, Elena, additional, Sadler, J. Evan, additional, Saenger, W., additional, Sahl, Hans-Georg, additional, Sajid, Mohammed, additional, Sakaguchi, Masayoshi, additional, Sakiyama, Fumio, additional, Salas, Maria L., additional, Salgado, Maria Cristina O., additional, Salvesen, Guy S., additional, Sánchez, Edith, additional, Sanchez, Eladio F., additional, Sang, Qing-Xiang Amy, additional, Sankaran, Krishnan, additional, Sarkar, Susanta K., additional, Sarras, Michael P., additional, Sasagawa, Yoshikiyo, additional, Satohiko, Araki, additional, Sauvage, Eric, additional, Saveanu, Loredana, additional, Savithri, H.S., additional, Sawada, Hitoshi, additional, Sawers, R. Gary, additional, Scarisbrick, Isobel A., additional, Schaller, Andreas, additional, Scheer, Justin M., additional, Scheiflinger, Friedrich, additional, Schiene-Fischer, Cordelia, additional, Schlomann, Uwe, additional, Schlösser, Manfred, additional, Schmaier, Alvin H., additional, Schmidt, Walter K., additional, Schneemann, Anette, additional, Schnellmann, Rick G., additional, Scholze, Henning, additional, Schomburg, Lutz, additional, Schwaeble, Wilhelm J., additional, Scott, Christopher J., additional, Scudiero, Rosaria, additional, Sehara-Fujisawa, Atsuko, additional, Seidah, Nabil G., additional, Seiki, Motoharu, additional, Sekiguchi, Junichi, additional, Senff-Ribeiro, Andrea, additional, Seong, Ihn Sik, additional, Serpe, Mihaela, additional, Serrano, Solange M.T., additional, Setlow, Peter, additional, Shahian, Tina, additional, Shanks, M., additional, Shao, Feng, additional, Shapiro, Steven D., additional, Sharma, Navneet, additional, Shaw, Lindsey N., additional, Shen, Aimee, additional, Shen, Lei, additional, Sherwood, Roger F., additional, Shi, Yun-Bo, additional, Shimoi, Hitoshi, additional, Shimura, Yoichiro, additional, Shirras, A.D., additional, Shridhar, Viji, additional, Shukla, Jinal K., additional, Siigur, Ene, additional, Siigur, Jüri, additional, Silmon de Monerri, Natalie C., additional, Sim, Robert B., additional, Simmer, James P., additional, Simmons, William H., additional, Singh, Jaspreet, additional, Singleton, Alison, additional, Sirakova, Tatiana D., additional, Sixma, Titia K., additional, Skern, Tim, additional, Skidgel, Randal A., additional, Slack, Jeffrey, additional, Sleat, David E., additional, Slusher, Barbara S., additional, Smith, Janet L., additional, Smith, Matthew A., additional, Smyth, Mark J., additional, Snijder, Erik J., additional, Sobhanifar, Solmaz, additional, Söderhaäll, Kenneth, additional, Sohar, Istvan, additional, Sonderegger, Peter, additional, Sorgine, Marcos Henrique Ferreira, additional, Sorimachi, Hiroyuki, additional, Soukhodolets, Karen E., additional, Souza, Tatiana de Arruda Campos Brasil de, additional, Sperka, Tamás, additional, Sriskandan, Shiranee, additional, St. Geme, Joseph W., additional, St. Leger, Raymond J., additional, Staib, Peter, additional, Steele, James L., additional, Stefansson, Bjarki, additional, Steinkühler, Christian, additional, Stenberg, Leisa M., additional, Stenflo, Johan, additional, Stennicke, Henning R., additional, Stepanov, Valentin M., additional, Stepnaya, Olga A., additional, Steven, Frank, additional, Stevens, Richard L., additional, Stevenson, Kenneth J., additional, St-Louis, Mathieu, additional, Stobart, Christopher C., additional, Stöcker, Walter, additional, Storer, Andrew C., additional, Sträter, Norbert, additional, Strauss, Ellen G., additional, Strauss, James H., additional, Stříšovský, Kvido, additional, Strynadka, Natalie C.J., additional, Sturrock, Edward D., additional, Su, Dan, additional, Su, Xiao-Dong, additional, Suárez-Rendueles, Paz, additional, Sulea, Traian, additional, Sundararajan, Venkatesh, additional, Suno, Ryoji, additional, Suzuki, Carolyn K., additional, Suzuki, Fumiaki, additional, Suzuki, Hideyuki, additional, Suzuki, Nobuhiro, additional, Swenson, Stephen, additional, Szabady, Rose L., additional, Szecsi, Pal Bela, additional, Szilágyi, Lászlo, additional, Taha, Muhamed-Kheir, additional, Takahashi, Eizo, additional, Takahashi, Kenji, additional, Takai, Toshiro, additional, Takeda, Atsushi, additional, Takeda, Soichi, additional, Tame, Jeremy J.R.H., additional, Tamura, Tomohiro, additional, Tan, Fulong, additional, Tanaka, Keiji, additional, Tanase, Carmen, additional, Tang, Jordan, additional, Tanizaki, Martha M., additional, Tannich, Egbert, additional, Tans, Guido, additional, Tarentino, Anthony L., additional, Tassanakajon, Anchalee, additional, Tatsumi, Hiroki, additional, Tautz, Norbert, additional, Taylor, Erin Bassford, additional, Teixeira, Pedro Filipe, additional, Telugu, Bhanu Prakash V.L., additional, Templin, Markus F., additional, Terada, Shigeyuki, additional, Tetsuya, Uchikoba, additional, Thacker, C., additional, Thaker, Maulik, additional, Thiel, Heinz-Jürgen, additional, Thielens, Nicole, additional, Thierry, Gonzales, additional, Thivierge, Karine, additional, Thomas, Mark D., additional, Thome, Margot, additional, Thorsness, Mary K., additional, Thorsness, Peter E., additional, Tigue, Natalie J., additional, Todi, Sokol V., additional, Tomkinson, Birgitta, additional, Tonello, Fiorella, additional, Tong, Liang, additional, Toogood, H.S., additional, Tortora, Paolo, additional, Tözsèr, József, additional, Travassos, Luiz Rodolpho, additional, Travis, James, additional, Trevisan-Silva, Dilza, additional, Trinchella, Francesca, additional, Trivedi, Neil N., additional, Troy, Carol M., additional, Tschesche, Harald, additional, Tseng, Yu-Lun, additional, Tsujimoto, Masafumi, additional, Tu, Anthony T., additional, Tumelty, Kathleen E., additional, Turk, Boris, additional, Turk, Dusan, additional, Turk, Vito, additional, Turner, Anthony J., additional, Uchikoba, Tetsuya, additional, Ueno, Takayuki, additional, Ugalde, Alejandro P., additional, Uitto, Veli-Jukka, additional, Urban, Sinisa, additional, Valdenaire, Olivier, additional, Valli, Adrian, additional, Van Beeumen, Jozef, additional, Van den Burg, Bertus, additional, Van der Hoorn, Renier A.L., additional, van Dijl, Jan Maarten, additional, Van Endert, Peter, additional, Van Raam, Bram J., additional, Van Wart, Harold E., additional, Vanden Berghe, Tom, additional, Vandenabeele, Peter, additional, Vanoni, Margo, additional, Veiga, Silvio Sanches, additional, Velander, William H., additional, Velasco, Gloria, additional, Vendrell, Josep, additional, Venekei, I. István, additional, Vetvicka, Vaclav, additional, Vögtle, F.-Nora, additional, Vollmer, Waldemar, additional, Wada, Kei, additional, Wagner, Fred W., additional, Wai, Sun Nyunt, additional, Wai, Timothy, additional, Wainwright, Shane, additional, Walker, Kenneth W., additional, Walker, Stephen J., additional, Wallach, Jean, additional, Walling, Linda L., additional, Walsh, Peter N., additional, Wang, Hai-Yan, additional, Wang, Hengbin, additional, Wang, Jianwei, additional, Wang, Peng, additional, Wang, Ping, additional, Wassenegger, Michael, additional, Watanabe, Kunihiko, additional, Webb, Helen, additional, Weber, Joseph M., additional, Weber, Niklas, additional, Webster, Daniel R., additional, Wei, Shuo, additional, Welch, Rodney A., additional, Wells, James A., additional, Wenzel, Herbert, additional, Wertz, Ingrid E., additional, Wewer, Ulla W., additional, Whyteside, Alison R., additional, Wilk, Sherwin, additional, Wilkin, Jean-Marc, additional, Wilmes, Claudia, additional, Winther, Jakob R., additional, Wishart, David S., additional, Wlodawer, Alexander, additional, Woessner, J. Fred, additional, Wolfe, Michael S., additional, Wong, Wilson, additional, Woodgate, Roger, additional, Wright, Gerry, additional, Wu, Jiunn-Jong, additional, Wu, Qingyu, additional, Wysocka, Magdalena, additional, Xu, Chao, additional, Xu, Zhenghong, additional, Yahori, Kinnosuke, additional, Yamada, Shoji, additional, Yamaguchi, Nozomi, additional, Yamaguchi, Shinji, additional, Yamakawa, Yoshio, additional, Yamamoto, Hiroki, additional, Yana, Ikao, additional, Yang, Maozhou, additional, Yang, Na, additional, Yao, Chenjuan, additional, Yao, Tingting, additional, Yasuda, Noriko, additional, Yasuhara, Toshimasa, additional, Yasumasu, Shigeki, additional, Yeh, Edward T.H., additional, Yiallouros, Irene, additional, Yin, Jiang, additional, Yonezawa, Hiroo, additional, Yoo, Soon Ji, additional, Yoshimoto, Tadashi, additional, Young, Michael W., additional, Young, Stephen G., additional, Zaidi, Nousheen, additional, Zavalova, Ludmila L., additional, Zavodszky, Peter, additional, Zhang, Aidong, additional, Zhang, Xianming, additional, Zhang, Yi-Zheng, additional, Zheng, Dominick, additional, Zhong, Guangming, additional, Zhong, Rong, additional, Zhou, Yuan, additional, Zhou, Zhaohui Sunny, additional, Zick, Michael, additional, Zigrino, Paola, additional, and Zimin, Andrei A., additional

Published
2013
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18. Furin

Author

Declercq, Jeroen, primary and Creemers, John W.M., additional

Published
2013
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23. Furin controls β cell function via mTORC1 signaling

Author

Brouwers, Bas, primary, Coppola, Ilaria, additional, Vints, Katlijn, additional, Dislich, Bastian, additional, Jouvet, Nathalie, additional, Van Lommel, Leentje, additional, Gounko, Natalia V., additional, Thorrez, Lieven, additional, Schuit, Frans, additional, Lichtenthaler, Stefan F., additional, Estall, Jennifer L., additional, Declercq, Jeroen, additional, Ramos-Molina, Bruno, additional, and Creemers, John W.M., additional

Published
2020
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25. Contributors

Author

Adachi, Hideki, primary, Adachi, Osao, additional, Adam, Zach, additional, Adams, Michael W.W., additional, Adang, Michael J., additional, Adham, Ibrahim M., additional, Aducci, Patrizia, additional, Agard, David A., additional, Agranovsky, Alexey A., additional, Ahn, Kyunghye, additional, Akiyama, Yoshinori, additional, Alejo, Alí, additional, Amberg, Sean M., additional, Amerik, Alexander Y., additional, Andrés, Germán, additional, Andrews, Robert K., additional, Antalis, Toni M., additional, Apte, Suneel S., additional, Arima, Kazunari, additional, Arlaud, Gérard J., additional, Aronson, Nathan N., additional, Asano, Yasuhisa, additional, Ascenzi, Paolo, additional, Assakura, Marina T., additional, Auld, David S., additional, Avilés, Francesc X., additional, Awad, William M., additional, Babé, Lilia M., additional, Badorff, Cornel, additional, Bai, Shan, additional, Baird, Teaster T., additional, Paul Bajaj, S., additional, Baker, Rohan T., additional, Baker, Susan C., additional, Ballinger, Marcus D., additional, Banbula, Agnieszka, additional, Bannikov, Gregory A., additional, Barrett, Alan J., additional, Bartlett, John D., additional, Baskova, Isolda P., additional, Bauer, Karl, additional, Baumann, Ulrich, additional, Baumeister, Wolfgang, additional, Beauvais, Anne, additional, Belas, Robert, additional, Beppu, Teruhiko, additional, Bergmann, Ernst M., additional, Bergo, Martin O., additional, Berndt, Michael C., additional, Berry, Colin, additional, Bertenshaw, Greg P., additional, Betzel, Ch., additional, Bierbaum, Gabriele, additional, Bieth, Joseph G., additional, Bjarnason, Jón B., additional, Blaber, M., additional, Blaber, S.I., additional, Black, Roy A., additional, Blackman, M.J., additional, Blinkovsky, Alexander, additional, Blobel, Carl P., additional, Boatright, Kelly M., additional, Böck, August, additional, Boeke, Jef D., additional, Boileau, Guy, additional, Bolken, Tové C., additional, Bond, Judith S., additional, Bordallo, Javier, additional, Bordusa, Frank, additional, Boucaut, Kerry J., additional, Bouvier, Jacques, additional, Bowman, Barry J., additional, Bradshaw, Ralph A., additional, Braun, Hans-Peter, additional, Breddam, Klaus, additional, Brindley, Paul J., additional, Broadhurst, Anne, additional, Brocklehurst, Keith, additional, Broder, Dan H., additional, Brömme, Dieter, additional, Bron, Sierd, additional, Broom, Murray, additional, Brown, Kenneth D., additional, Brown, Mark A., additional, Bunn, Rhonda, additional, Burleigh, Barbara A., additional, Butler, Michael J., additional, Buttle, David J., additional, Byrd, Chelsea M., additional, Byun, Tony, additional, Cadel, Sandrine, additional, Caffrey, Conor R., additional, Caldentey, Javier, additional, Caprioglio, Daniel R., additional, Carbonell, Juan, additional, Carpentier, Mélanie, additional, Carter, Ruth E., additional, Casey, Patrick J., additional, Castellino, Francis J., additional, Catanese, Joseph J., additional, Caterson, Bruce, additional, Caughey, George H., additional, Cawley, Niamh X., additional, Cawston, Tim E., additional, Jose Cazzulo, Juan, additional, Cercós, Manuel, additional, Chakraborty, Trinad, additional, Chambers, Henry F., additional, Chang, L.S., additional, Chan, Michael K., additional, Chan, Sunney I., additional, Chao, Julie, additional, Chapot-Chartier, Marie-Pierre, additional, Chave, Karen J., additional, Chen, Jian-Min, additional, Chen, Jinq-May, additional, Chesneau, Valérie, additional, Chevrier, Bernard, additional, Chich, Jean-François, additional, Yong Choi, Kwan, additional, Chrétien, Michel, additional, Ha Chung, Chin, additional, Chung, Dominic W., additional, Clamagirand, Christine, additional, Clark, Ian M., additional, Clarke, Adrian K., additional, Clarke, Steven, additional, Cleary, Paul P., additional, Clements, Judith A., additional, Cleuziat, Philippe, additional, Cohen, Paul, additional, Colige, Alain, additional, Collen, D., additional, Collier, Ivan E., additional, Colloms, Sean D., additional, Colman, Robert W., additional, Conner, Gregory E., additional, Conzelmann, Andreas, additional, Coolbear, Tim, additional, Coombs, Graham H., additional, Cooper, Jonathan B., additional, Cooper, Max D., additional, Copeland, Nikki A., additional, Corvol, Pierre, additional, Cottrell, Graeme S., additional, Coyle, Joseph T., additional, Craik, Charles S., additional, Creemers, John W.M., additional, Croce, Jenifer, additional, Cueva, Rosario, additional, Cutting, Simon, additional, d′Enfert, Christophe, additional, D′Orchymont, Hugues, additional, Daenke, S., additional, Dahlbäck, Björn, additional, Dalbey, Ross E., additional, Dalton, John P., additional, Dando (Deceased), Pamela M., additional, Daniel, R.M., additional, Darke, Paul L., additional, Lagerblad de Oliveira, Pedro, additional, de Vos, Sarah, additional, Deghmane, Ala-Eddine, additional, Dekker, Niek, additional, DeLotto, Robert, additional, DeMartino, George N., additional, den Boon, Johan A., additional, Denison, Mark R., additional, DesGroseillers, Luc, additional, Deussing, Jan, additional, Devi, Lakshmi A., additional, Diamandis, Eleftherios P., additional, Dickson, Robert B., additional, Dingwall, Colin, additional, Dixon, Jack E., additional, Dodt, Johannes, additional, Dolenc, Iztoc, additional, Cat Dong, Tran, additional, Dong, Ying, additional, Dubois, Jean-Yves F., additional, Dudley, Edward G., additional, Dunn, Ben M., additional, Dupuy, Bruno, additional, Conceicão Duque-Magalhães, Maria, additional, Eeckhout, Yves, additional, Egelrud, Torbjörn, additional, Eijsink, Vincent, additional, Ellis, Vincent, additional, Engel, Wolfgang, additional, Erdös, Ervin G., additional, Etscheid, Michael, additional, Evans (Deceased), Herbert J., additional, Everett, Roger D., additional, Eyries, Mélanie, additional, Fahrenholz, Falk, additional, Fenster, Kurt M., additional, Férec, Claude, additional, Henrique Ferreira Sorgine, Marcos, additional, Fink, Doran, additional, Fives-Taylor, Paula M., additional, Foltmann, Bent, additional, Foster, Simon J., additional, Foulon, Thierry, additional, Foundling, Stephen I., additional, Fox, Jay W., additional, Freeze, Hudson H., additional, Frère, Jean-Marie, additional, Frey, Teryl K., additional, Flicker, Lloyd D., additional, Fritsche, Erich, additional, Froelich, Christopher J., additional, Fuhrmann, Cynthia N., additional, Fujimura, Satoshi, additional, Fukushima, J., additional, Fuller, Robert S., additional, Gaboriaud, Christine, additional, Gache, Christian, additional, Galivan, John, additional, Gary, Jonathan D., additional, Gaucher, G.M., additional, Ghuysen, Jean-Marie, additional, Gil, María J., additional, Giller, Thomas, additional, Goffin, Colette, additional, Gohda, Eiichi, additional, Goldberg, Alfred L., additional, Goldberg, Daniel E., additional, Goldberg, Gregory I., additional, Gorbalenya, Alexander E., additional, Gordon, Stuart G., additional, Götz, Friedrich, additional, Gráf, László, additional, Granados, Robert R., additional, Granell, Antonio, additional, Graycar, Thomas P., additional, Green, Jonathan, additional, Greenspan, Daniel S., additional, Grubman, Marvin J., additional, Grunden, Amy M., additional, Guillemain, Bernard, additional, Guinand, Micheline, additional, Gutiérrez, José Maria, additional, Haeggström, Jesper Z., additional, Hageman, James H., additional, Hagmann, Marie-Luise, additional, Halfon, Sherin, additional, Hamilton, Andrew J., additional, Seon Han, Ji, additional, Hara-Nishimura, Ikuko, additional, Harada, Minoru, additional, Hartzell, William O., additional, Hay, Rod J., additional, Hayashi, Kiyoshi, additional, Hendriks, Dirk F., additional, Henrich, Bernhard, additional, Henriet, Patrick, additional, Hernández-Arana, Andrés, additional, Herrera-Camacho, Irma, additional, Heusipp, Gerhard, additional, Hicks, P.M., additional, Hillman, Bradley I., additional, Yukihiro Hiraoka, B., additional, Hiratake, Jun, additional, Ho, Heng-Chien, additional, Thi Hoa, Ngo, additional, Hochstrasser, Mark, additional, Hofmann, Theo, additional, Hohn, Thomas, additional, Hoidal, John R., additional, Holbrook, Joanna D., additional, Höltje, Joachim-Volker, additional, Homma, Koichi J., additional, Hook, Vivian Y.H., additional, Hooper, John D., additional, Hooper, Nigel M., additional, Hosoi, Kazuo, additional, Hospital, Véronique, additional, Howe, Christopher J., additional, Hruby, Dennis E., additional, Huang, H.-C., additional, Huber, Robert, additional, Hughes, Clare E., additional, Ibrahim-Granet, Oumaïma, additional, Ichishima, Eiji, additional, Ikehara, Yukio, additional, Imamura, Takahisa, additional, Inagaki, Noritoshi, additional, Inagami, Tadashi, additional, Isaac, R.E., additional, Isaya, Grazia, additional, Ishihara, Kohji, additional, Ishii, Shin-ichi, additional, Itoh, Yoshifumi, additional, Ito, Kiyoshi, additional, Ito, Koreaki, additional, Iwanaga, Sadaaki, additional, Jack, Ralph W., additional, Jackson, Mel C., additional, James, Michael N.G., additional, Jeffrey (Deceased), John, additional, Jiang, Ping, additional, Johnson, Gary D., additional, Johnson, John E., additional, Johnson, Michael, additional, Albert Johnston, Stephen, additional, Jones, Elizabeth W., additional, Jongbloed, Jan D.H., additional, Joshua-Tor, Leemor, additional, Joudiou, Carine, additional, Juliano, Luiz, additional, Jupp, Ray, additional, Kaminogawa, Shuichi, additional, Kamio, Yoshiyuki, additional, Kan, Chen-Chen, additional, Kaneda, Makoto, additional, Gyun Kang, Sung, additional, Kania, Mary, additional, Kanjanahaluethai, Amornrat, additional, Kawabata, Shun-ichiro, additional, Kay, John, additional, Keiler, Kenneth C., additional, Kelly, R.M., additional, Kerr, Michael A, additional, Kervinen, Jukka, additional, Kessler, Efrat, additional, Kidd, Simon, additional, Kilian, Mogens, additional, Kim, Do-Hyung, additional, Seop Kim, In, additional, Kimura, Yukio, additional, Kirisako, Takayoshi, additional, Kirschke, Heidrun, additional, Kishi, Tadaaki, additional, Kitamura, Naomi, additional, Kitazono, Ana A., additional, Kleanthous, Colin, additional, Klein, Jürgen R., additional, Kobayashi, Hideyuki, additional, Koelsch, Gerald, additional, Kok, Jan, additional, Kolattukudy, P.E., additional, Kolmar, Harald, additional, Komori, Yumiko, additional, Konvalinka, Jan, additional, Korhonen, Timo K., additional, Kortt, Alexander A., additional, Kräusslich, Hans-Georg, additional, Kress, Lawrence F., additional, Kubo, Takeaki, additional, Kukkonen, Maini, additional, Kumagai, Hidehiko, additional, Kumazaki, Takashi, additional, Kümmerer, Beate M., additional, Kuno, Kouji, additional, Kurachi, Kotoku, additional, Kurkinen, Markku, additional, Lähteenmäki, Kaarina, additional, Laing, Gavin D., additional, Lambkin, Imelda J., additional, Lamppa, Gayle K., additional, Lång, Hannu, additional, Langer, Thomas, additional, Laursen, Richard A., additional, Le Bonniec, Bernard F., additional, Luel Lee, Bok, additional, Joon Lee, Kye, additional, Young Lee, So, additional, Lee, Soohee, additional, Leis, Jonathan, additional, LeMosy, Ellen K., additional, Lepage, Thierry, additional, Leppla, Stephen H., additional, Lessard, Ivan A.D., additional, Lhomond, Guy, additional, Liao, Ta-Hsiu, additional, Lieber, Toby, additional, Lijnen, H.R., additional, Lima, Christopher D., additional, Lin, Chen-Yong, additional, Lin, Xinli, additional, Lindsay, L.L., additional, Lipscomb, William N., additional, Little, Christopher B., additional, Little, John W., additional, Lively, Mark O., additional, Lobel, Peter, additional, Peng Loh, Y., additional, Lohi, Jouko, additional, Lomonossoff, G.P., additional, Looze, Yvan, additional, López-García, Alma, additional, López-Otín, Carlos, additional, Luo, Liu-Ying, additional, Lupas, Andrei, additional, MacKay, Vivian L., additional, Mains, Richard E., additional, Mäkinen, Kauko K., additional, Mäkinen, Pirkko-Liisa, additional, Mandelbaum, Fajga R., additional, Manning, James M., additional, Marcotrigiano, Joseph, additional, Markland, Francis S., additional, Maruyama, M., additional, Maruyama, Sususmu, additional, Masaki, Takeharu, additional, Mathew, Zacharia, additional, Matrisian, Lynn M., additional, Matsuda, Yoshihiro, additional, Matsuka, Yury V., additional, Matsushita, Osamu, additional, Matsuzawa, Hiroshi, additional, Maurizi, Michael R., additional, Mbikay, Majambu, additional, Ken McDonald, J., additional, McKerrow, James H., additional, McMillan, David, additional, Mecham, Robert P., additional, Mehta, Darshini P., additional, Meighan, Paul, additional, Mellors, Alan, additional, Melton, Roger G., additional, Ménard, Armelle, additional, Ménard, Robert, additional, Menéndez-Arias, Luis, additional, Meyer, Diane H., additional, Meyers, Gregor, additional, Michaelis, Susan, additional, Mielicki, Wojciech P., additional, Mierau, Igor, additional, Millán-Pérez-Peña, Lourdes, additional, Miller, Charles G., additional, Mills, John, additional, Mills, Kenneth V., additional, Mistou, Michel-Yves, additional, Misumi, Yoshio, additional, Miyoshi, Shin-ichi, additional, Mizutani, Shigehiko, additional, Mock, William L., additional, Möhrlen, Frank, additional, Moiré, Nathalie, additional, Monnet, Véronique, additional, Monod, Michel, additional, Montecucco, Cesare, additional, Morita, Takashi, additional, Morrissey, James H., additional, Mort, John S., additional, Mortensen, Uffe H., additional, Morty, Rory E., additional, Motoshima, Hidemasa, additional, Mottram, Jeremy C., additional, Mundt, Egbert, additional, Murakami, Kazuo, additional, Murakami-Murofushi, Kimiko, additional, Murao, Sawao, additional, Murata, Christina, additional, Murphy, Gillian, additional, Muta, Tatsushi, additional, Mzhavia, Nino, additional, Nagase, Hideaki, additional, Naik, Rajesh R., additional, Nakajima, Nobuyoshi, additional, Nakamura, Hiroyuki, additional, Nakamura, Yukio, additional, Nasmyth, Kim, additional, Navarro-García, Fernando, additional, Netzel-Arnett, Sarah, additional, Nguyen-Distéche, Martine, additional, Nicholson, Donald, additional, Nikai, Toshiaki, additional, Nirasawa, Satoru, additional, Nishii, Wataru, additional, Nishiyama, Makoto, additional, Niven, Gordon W., additional, Nomura, Seiji, additional, Norioka, Shigemi, additional, North, Michael J., additional, Nuss, Donald L., additional, O′Connor, Michael B., additional, Oberst, Michael, additional, Oda, Kohei, additional, Odorico, Dimitri M., additional, Oetjen, Joyce, additional, Ogura, Teru, additional, Ohkubo, Iwao, additional, Ohlendorf, Douglas H., additional, Ohman, Dennis E., additional, Ohsumi, Yoshinori, additional, Okabe, Akinobu, additional, Okuda, K., additional, Olesen, Kjeld, additional, Oroszlan, Stephen, additional, Orth, Kim, additional, Ota, Nobuyuki, additional, Ovadia, Michael, additional, Overgaard, Michael T., additional, O-Wang, Jiyang, additional, Oxvig, Claus, additional, Packer, Jeremy C.L., additional, Paetzel, Mark, additional, Paine, Mark J.I., additional, Park, John E., additional, Woo Park, Pyong, additional, Soo Park, Sung, additional, Parkin, Kirk L., additional, Parks, William C., additional, Pascall, John C., additional, Paschos, Athanasios, additional, Paul, Sudhir, additional, Pearce, David A., additional, Pei, Duanqing, additional, Pemberton, Alan D., additional, Peters, Jan-Michael, additional, Phylip, Lowri H., additional, Pichová, Iva, additional, Pieper, Michael, additional, Piesse, Christophe, additional, Pike, Rob, additional, Pinck, Lothaire, additional, Pirzad, Ramin, additional, Pitot, Henry C., additional, Plaut, Andrew G., additional, Polgár, László, additional, Postina, Rolf, additional, Potempa, Jan, additional, Poulsen, Knud, additional, Pritchard, David G., additional, Pshezhetsky, Alexey V., additional, Abul Qasim, M., additional, Rader, Stephen D., additional, Rando, Robert R., additional, Rao, Mala, additional, Rao, Narayanam V., additional, Ratnoff, Oscar D., additional, Rawlings, Neil D., additional, Rawson, Robert B., additional, Reddy, Vijay, additional, Redman, Colvin M., additional, Reichl (Deceased), Antonia P., additional, Reid, Julian R., additional, Reid, Kenneth B.M., additional, Remaut, Han, additional, James Remington, S., additional, Rettig, Wolfgang J., additional, Rholam, Mohamed, additional, Rice, Charles M., additional, Richter, Stefan, additional, Riezman, Howard, additional, Ritchie, Alison, additional, Ro, Hyo-Sung, additional, Robert-Baudouy, Janine, additional, Michael Roberts, R., additional, Robinson, Michael, additional, Rodríguez-Romero, Adela, additional, Rogers, John C., additional, Rosenthal, Philip J., additional, Rose, A.M., additional, Rosing, J., additional, Rossetto, Ornella, additional, Rossi, Cesare, additional, Rossi, Véronique, additional, Roth, Richard A., additional, Rowan, Andrew D., additional, Rozanov, Mikhail, additional, Rucavado, Alexandra, additional, Rul, Françoise, additional, Rümenapf, Tillmann, additional, Ryan, Martin D., additional, Ryan, Thomas J., additional, Sacco, Elena, additional, Evan Sadler, J., additional, Saenger, W., additional, Sahl, Hans-Georg, additional, Sajid, Mohammed, additional, Sakiyama, Fumio, additional, Salas, María L., additional, Salter, Jason P., additional, Salvesen, Guy S., additional, Sanchez, Eladio F., additional, Sang, Qing-Xiang Amy, additional, Sankaran, Krishnan, additional, Sarras, Michael P., additional, Sasagawa, Yoshikiyo, additional, Satoh, Kimiyuki, additional, Sauer, Robert T., additional, Sawada, Hitoshi, additional, Scarisbrick, I.A., additional, Schauer-Vukasinovic, Vesna, additional, Schlievert, Patrick M., additional, Schlösser, Manfred, additional, Schmidt, Amy E., additional, Schmidt, Brian F., additional, Schmidt, Walter K., additional, Schmitz, Udo K., additional, Schneemann, Anette, additional, Scholze, Henning, additional, Schomburg, Lutz, additional, Schwaeble, Wilhelm J., additional, Sedlacek, Radislav, additional, Seemüller, Erika, additional, Seidah, Nabil G., additional, Seiki, Motoharu, additional, Selistre de Araujo, Heloisa S., additional, Senior, Robert M., additional, Sik Seong, Ihn, additional, Serpe, Mihaela, additional, Serrano, Solange M.T., additional, Setlow, Peter, additional, Shanks, M., additional, Shao, Feng, additional, Shapiro, Steven D., additional, Shen, Lei, additional, Sherwood (Deceased), Roger F., additional, Shi, Yun-Bo, additional, Shimoi, Hitoshi, additional, Shinoda, Sumio, additional, Siigur, Ene, additional, Siigur, Jüri, additional, Sim, Robert B., additional, Simmer, James P., additional, Simmons, William H., additional, Sirakova, Tatiana D., additional, Skern, Tim, additional, Skidgel, Randal A., additional, Slack, Jeffrey, additional, Sleat, David E., additional, Smith, Janet L., additional, Smyth, Mark J., additional, Snijder, Eric J., additional, Söderhäll, Kenneth, additional, Sohar, Istvan, additional, Sorimachi, Hiroyuki, additional, Sottrup-Jensen, Lars, additional, Soubrier, Florent, additional, Soukhodolets, Karen E., additional, Springman, Eric B., additional, Geme, Joseph W. St., additional, Leger, Raymond J. St., additional, Steele, James L., additional, Steinkühler, Christian, additional, Stenberg, Leisa M., additional, Stenflo, Johan, additional, Stennicke, Henning R., additional, Stepanov (Deceased), Valentin M., additional, Steven, Frank, additional, Stevenson, Kenneth J., additional, Stewart, David J., additional, Storer, Andrew C., additional, Stover, Cordula, additional, Sträter, Norbert, additional, Strauss, Ellen G., additional, Strauss, James H., additional, Stöcker, Walter, additional, Stříšovský, Kvido, additional, Suárez-Rendueles, Paz, additional, Sugimoto, Manabu, additional, Sulea, Traian, additional, Suzuki, Fumiaki, additional, Suzuki, Hideyuki, additional, Swenson, Stephen, additional, Szecsi, Pal B., additional, Szilágyi, László, additional, Taha, Muhamed-Kheir, additional, Takahashi, Kenji, additional, Takio, Koji, additional, Tamura, Tomohiro, additional, Tan, Fulong, additional, Hong Tan, Nget, additional, Tanase, Carmen, additional, Tang, Jordan, additional, Tanizaki, Martha M., additional, Tannich, Egbert, additional, Tans, G., additional, Tarentino (Deceased), Anthony L., additional, Tatnell, Peter J., additional, Tatsumi, Hiroki, additional, Tautz, Norbert, additional, Templin, Markus F., additional, Terada, Shigeyuki, additional, Thacker, C., additional, Theodoratou, Ekaterini, additional, Thiel, Heinz-Jürgen, additional, Thielens, Nicole M., additional, Thierry, Gonzales, additional, Thomas, Mark D., additional, Thornberry, Nancy A., additional, Thorsness, Mary K., additional, Thorsness, Peter E., additional, Tigue, Natalie J., additional, Tjalsma, Harold, additional, Tomkinson, Birgitta, additional, Tonello, Fiorella, additional, Toogood, H.S., additional, Toombs, Christopher, additional, Tortora, Paolo, additional, Tözsér, József, additional, Travis, James, additional, Tschesche, Harald, additional, Tsujimoto, Masafumi, additional, Tsunasawa, Susumu, additional, Tsu, Christopher A., additional, Tu, Anthony T., additional, Turk, Boris, additional, Turk, Dusan, additional, Turk, Vito, additional, Turner, Anthony J., additional, Uchikoba, Tetsuya, additional, Uitto, Veli-Jukka, additional, Ullmann, Dirk, additional, Valdenaire, Olivier, additional, Van Beeumen, Jozef, additional, Van de Ven, Wim J.M., additional, van den Burg, Bertus, additional, Maarten van Dijl, Jan, additional, van Roosmalen, Maarten L., additional, Van Wart, Harold E., additional, Vanoni, Marco, additional, Vath, Gregory M., additional, Velasco, Gloria, additional, Vendrell, Josep, additional, Venekei, István, additional, Vera, Pablo, additional, Verchot-Lubicz, Jeanmarie, additional, Vines, Richard R., additional, Volanakis, John E., additional, Wagner, Fred W., additional, Wainwright, Shane W., additional, Walker, Kenneth W., additional, Walker, Stephen J., additional, Wallach, Jean, additional, Walling, Linda L., additional, Walsh, Peter N., additional, Wang, P., additional, May Wang, Q., additional, Wassenaar, Alfred L.M., additional, Watts, Aaron B., additional, Weber, Joseph M., additional, Webster, Daniel R., additional, Weiss, Stephen J., additional, Wells, James A., additional, Wenzel, Herbert, additional, Wewer, Ulla M., additional, White, Judith M., additional, Wilk, Sherwin, additional, Wilkin, Jean-Marc, additional, Wilkins, Tracy D., additional, Wilkinson, Keith D., additional, Winther, Jakob R., additional, Wlodawer, Alexander, additional, Fred Woessner, J., additional, Wolfe, Michael S., additional, Wolfsberg, Tyra G., additional, Woodgate, Roger, additional, Wright, G.D., additional, Wu, Qingyu, additional, Xie, Sancai, additional, Yamagami, Kenjiro, additional, Yamaguchi, Nozomi, additional, Yamakawa, Yoshio, additional, Yamamoto, Kei, additional, Yamamoto, Shigeo, additional, Yana, Ikuo, additional, Yang, Maozhou, additional, Yasuda, Noriko, additional, Yasuhara, Toshimasa, additional, Yasumasu, Shigeki, additional, Yi, Elizabeth, additional, Yiallouros, Irene, additional, Yonezawa, Hiroo, additional, Ji Yoo, Soon, additional, Yoshimoto, Tadashi, additional, Young, Michael W., additional, Young, Stephen G., additional, Zavalova, Ludmila L., additional, Zdanov, Alexander, additional, and Zhang, Hong-Zhong, additional

Published
2004
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26. Alternative Promoters

Author

Jansen, Erik, primary, Ayoubi, Torik A.Y., additional, Van de Ven, Wim J.M., additional, and Creemers, John W.M., additional

Published
2004
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29. Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

Author

Jackson, Robert S., Creemers, John W.M., Farooqi, I. Sadaf, Raffin-Sanson, Marie-Laure, Varro, Andrea, Dockray, Graham J., Holst, Jens J., Brubaker, Patricia L., Corvol, Pierre, Polonsky, Kenneth S., Ostrega, Diane, Becker, Kenneth L., Bertagna, Xavier, Hutton, John C., White, Anne, Dattani, Mehul T., Hussain, Khalid, Middleton, Stephen J., Nicole, Thomasina M., Milla, Peter J., Lindley, Keith J., and O'Rahilly, Stephen

Published
2003

31. Loss of in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction.

Author

Brouwers, Bas, Coppola, Ilaria, Vints, Katlijn, Dislich, Bastian, Jouvet, Nathalie, Van Lommel, Leentje, Segers, Charlotte, Gounko, Natalia V., Thorrez, Lieven, Schuit, Frans, Lichtenthaler, Stefan F., Estall, Jennifer L., Declercq, Jeroen, Ramos-Molina, Bruno, and Creemers, John W.M.

Subjects
PROTEIN precursors, TYPE 2 diabetes, SECRETORY granules, TRANSCRIPTION factors, PROTEIN microarrays, PROTEIN metabolism, RESEARCH, ANIMAL experimentation, RESEARCH methodology, PROTEOLYTIC enzymes, MEDICAL cooperation, EVALUATION research, ISLANDS of Langerhans, CELLULAR signal transduction, COMPARATIVE studies, MICE
Abstract

FURIN is a proprotein convertase (PC) responsible for proteolytic activation of a wide array of precursor proteins within the secretory pathway. It maps to the PRC1 locus, a type 2 diabetes susceptibility locus, but its specific role in pancreatic β-cells is largely unknown. The aim of this study was to determine the role of FURIN in glucose homeostasis. We show that FURIN is highly expressed in human islets, whereas PCs that potentially could provide redundancy are expressed at considerably lower levels. β-cell-specific Furin knockout (βFurKO) mice are glucose intolerant as a result of smaller islets with lower insulin content and abnormal dense-core secretory granule morphology. mRNA expression analysis and differential proteomics on βFurKO islets revealed activation of activating transcription factor 4 (ATF4), which was mediated by mammalian target of rapamycin C1 (mTORC1). βFurKO cells show impaired cleavage or shedding of vacuolar-type ATPase (V-ATPase) subunits Ac45 and prorenin receptor, respectively, and impaired lysosomal acidification. Blocking V-ATPase pharmacologically in β-cells increased mTORC1 activity, suggesting involvement of the V-ATPase proton pump in the phenotype. Taken together, these results suggest a model of mTORC1-ATF4 hyperactivation and impaired lysosomal acidification in β-cells lacking Furin, causing β-cell dysfunction. [ABSTRACT FROM AUTHOR]

Published
2021
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33. PREPL deficiency: delineation of the phenotype and development of a functional blood assay

Author

Régal, Luc, primary, Mårtensson, Emma, additional, Maystadt, Isabelle, additional, Voermans, Nicol, additional, Lederer, Damien, additional, Burlina, Alberto, additional, Juan Fita, María Jesús, additional, Hoogeboom, A. Jeannette M., additional, Olsson Engman, Mia, additional, Hollemans, Tess, additional, Schouten, Meyke, additional, Meulemans, Sandra, additional, Jonson, Tord, additional, François, Inge, additional, Gil Ortega, David, additional, Kamsteeg, Erik-Jan, additional, and Creemers, John W.M., additional

Published
2018
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40. Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice

Author

Nuytens, Kim, primary, Gantois, Ilse, additional, Stijnen, Pieter, additional, Iscru, Emilia, additional, Laeremans, Annelies, additional, Serneels, Lutgarde, additional, Van Eylen, Lien, additional, Liebhaber, Stephen A., additional, Devriendt, Koen, additional, Balschun, Detlef, additional, Arckens, Lutgarde, additional, Creemers, John W.M., additional, and D'Hooge, Rudi, additional

Published
2013
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43. Proprotein convertases in human atherosclerotic plaques: The overexpression of FURIN and its substrate cytokines BAFF and APRIL

Author

Turpeinen, Hannu, primary, Raitoharju, Emma, additional, Oksanen, Anna, additional, Oksala, Niku, additional, Levula, Mari, additional, Lyytikäinen, Leo-Pekka, additional, Järvinen, Otso, additional, Creemers, John W.M., additional, Kähönen, Mika, additional, Laaksonen, Reijo, additional, Pelto-Huikko, Markku, additional, Lehtimäki, Terho, additional, and Pesu, Marko, additional

Published
2011
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