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23 results on '"Creedon, Niamh"'

2. Suppression of Impedimetric Baseline Drift for Stable Biosensing

Author

Gezahagne, Hilena F., primary, Brightbill, Eleanor L., additional, Jin, Decarle S., additional, Krishnathas, Siamalan, additional, Brown, Billyde, additional, Mooney, Mark H., additional, O’Riordan, Alan, additional, Creedon, Niamh, additional, Robinson, Caoimhe, additional, and Vogel, Eric M., additional

Published
2022
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12. Sensing at nanostructures for agri-food and enviromental applications

Author

Creedon, Niamh and O'Riordan, Alan

Subjects
Neonicotinoids, Electrochemical sensor, Bovine respiratory disease, SERS, Nanotechnology, Impedance
Abstract

With a predicted population increase of 2.3 billion people, by 2050, agricultural productivity must be vastly improved and made sustainable. Globally, agriculture must deliver a 60% increase in food production to cope with the population demand. Moreover, this needs to be achieved against a changing climate, an exploitation of natural resources, and growing water and land scarcities. New digital technologies can optimise production efficiency and ensure food security and safety while also minimising waste within the production systems and the supply chain. To this end, new sensor technologies are being developed for applications in animal health diagnostics and environmental issues related to the global population, such as food & crop protection, pathogen and toxin detection, and environmental remediation. In this thesis, two new nanosensing diagnostic devices are developed and presented; surface enhanced Raman sensing and electrochemical sensing. Surface-enhanced Raman spectroscopy (SERS) substrates were fabricated by templating a flexible thermoplastic polymer against an aluminium drinks can followed by coating with a silver film, to produce a rough nanostructured metallic surface. SERS is used for both qualitative (molecular fingerprint) and quantitative detection of dye molecules and food toxins. In addition, the SERS technique is also applied in combination with nanoelectrochemical square wave voltammetry to detect nano-concentrations of neonicotinoid pesticides. The enhanced sensitivity and minimum sample preparation requirements provide tremendous opportunities for food safety and security sectors. An impedimetric immunosensor device (with a micro SD style pin-out) was also developed for the serological diagnosis of viruses and antibodies associated with bovine respiratory disease and bovine liver fluke. The silicon chip devices consist of six on-chip nanoband electrodes which can be independently modified with a polymer layer for covalent immobilisation of capture and target biomolecules. This electrochemical biosensor technology provides label-free and cost-efficient sensing capability in a compact size, and demonstrates the potential development of immunoassay-based point-of-use devices for on-farm diagnosis or therapeutic monitoring in animal health applications.

Published
2018

17. Direct correlation between potentiometric and impedance biosensing of antibody-antigen interactions using an integrated system

Author

Tsai, Meng-Yen, primary, Creedon, Niamh, additional, Brightbill, Eleanor, additional, Pavlidis, Spyridon, additional, Brown, Billyde, additional, Gray, Darren W., additional, Shields, Niall, additional, Sayers, Ríona, additional, Mooney, Mark H., additional, O'Riordan, Alan, additional, and Vogel, Eric M., additional

Published
2017
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18. A potentiometric biosensor for rapid on-site disease diagnostics

Author

Tarasov, Alexey, primary, Gray, Darren W., additional, Tsai, Meng-Yen, additional, Shields, Niall, additional, Montrose, Armelle, additional, Creedon, Niamh, additional, Lovera, Pierre, additional, O'Riordan, Alan, additional, Mooney, Mark H., additional, and Vogel, Eric M., additional

Published
2016
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19. A Universal Surface for Label-Free Electrical and Optical Sensing of Disease Markers

Author

Tsai, Meng-Yen, primary, Tarasov, Alexey, additional, Gray, Darren W, additional, Shields, Niall, additional, Creedon, Niamh, additional, Montrose, Armelle, additional, Flynn, Erin M, additional, Joiner, Corey A, additional, Taylor, Robert, additional, Lovera, Pierre, additional, O' Riordan, Alan, additional, Mooney, Mark H, additional, and Vogel, Eric M, additional

Published
2016
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20. Direct correlation between potentiometric and impedance biosensing of antibody-antigen interactions using an integrated system.

Author

Meng-Yen Tsai, Creedon, Niamh, Brightbill, Eleanor, Pavlidis, Spyridon, Brown, Billyde, Gray, Darren W., Shields, Niall, Sayers, Ríona, Mooney, Mark H., O'Riordan, Alan, and Vogel, Eric M.

Subjects
*POTENTIOMETRY, *BIOSENSORS, *IMPEDANCE spectroscopy, *BLOOD plasma, *CHARGE transfer, *BIOMOLECULES
Abstract

A fully integrated system that combines extended gate field-effect transistor (EGFET)-based potentiometric biosensors and electrochemical impedance spectroscopy (EIS)-based biosensors has been demonstrated. This integrated configuration enables the sequential measurement of the same immunological binding event on the same sensing surface and consequently sheds light on the fundamental origins of sensing signals produced by FET and EIS biosensors, as well as the correlation between the two. Detection of both the bovine serum albumin (BSA)/anti-BSA model system in buffer solution and bovine parainfluenza antibodies in complex blood plasma samples was demonstrated using the integrated biosensors. Comparison of the EGFET and EIS sensor responses reveals similar dynamic ranges, while equivalent circuit modeling of the EIS response shows that the commonly reported total impedance change (DZtotal) is dominated by the change in charge transfer resistance (Rct) rather than surface capacitance (Csurface). Using electrochemical kinetics and the Butler-Volmer equation, we unveil that the surface potential and charge transfer resistance, measured by potentiometric and impedance biosensors, respectively, are, in fact, intrinsically linked. This observation suggests that there is no significant gain in using the FET/EIS integrated system and leads to the demonstration that low-cost EGFET biosensors are sufficient as a detection tool to resolve the charge information of biomolecules for practical sensing applications. [ABSTRACT FROM AUTHOR]

Published
2017
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