185 results on '"Craessaerts, Katleen"'
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2. Local mitochondrial replication in the periphery of neurons requires the eEF1A1 protein and the translation of nuclear-encoded proteins
3. NACC2, a molecular effector of miR-132 regulation at the interface between adult neurogenesis and Alzheimer’s disease
4. MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
5. Differential Contribution of the Three Aph1 Genes to γ-Secretase Activity in vivo
6. Neuronal Membrane Cholesterol Loss Enhances Amyloid Peptide Generation
7. The two faces of synaptic failure in AppNL-G-F knock-in mice
8. The Discrepancy between Presenilin Subcellular Localization and γ-Secretase Processing of Amyloid Precursor Protein
9. Presenilin 2 Deficiency Causes a Mild Pulmonary Phenotype and no Changes in Amyloid Precursor Protein Processing but Enhances the Embryonic Lethal Phenotype of Presenilin 1 Deficiency
10. Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease
11. MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease
12. Microglial Expression of the Wnt Signaling ModulatorDKK2Differs between Human Alzheimer’s Disease Brains and Mouse Neurodegeneration Models
13. Astrocytes mediate neuronal network hyperactivity in early AD
14. PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling
15. Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease
16. Deep proteomic analysis of human microglia and model systems reveal fundamental biological differences ofin vitroandex vivocells
17. Microglial expression of the Wnt signalling modulator DKK2 differs between human Alzheimer’s disease brains and mouse neurodegeneration models
18. γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease
19. Microglial Expression of theWnt Signaling Modulator DKK2 Differs between Human Alzheimer's Disease Brains andMouse Neurodegeneration Models.
20. Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease
21. Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease
22. [Gamma]-secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease
23. Melanin Concentrating Hormone- and sleep-dependent synaptic downscaling is impaired in Alzheimer’s Disease
24. Deep proteomic analysis of microglia reveals fundamental biological differences between model systems
25. Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes
26. Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease
27. Differential contribution of the three Aph1 genes to [gamma]-secretase activity in vivo
28. Developmental Expression of Wild-Type and Mutant Presenilin-1 in Hippocampal Neurons from Transgenic Mice: Evidence for Novel Species-Specific Properties of Human Presenilin-1
29. Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease
30. Impaired adult hippocampal neurogenesis in Alzheimer’s disease is mediated by microRNA-132 deficiency and can be restored by microRNA-132 replacement
31. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
32. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
33. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice
34. CALL interrupted in a patient with non-specific mental retardation: gene dosage-dependent alteration of murine brain development and behavior
35. Gene profiling of hippocampal neuronal culture
36. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for α-secretase activity in fibroblasts
37. The amyloid precursor protein (APP)-cytoplasmic fragment generated by γ-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture
38. Pathogenic APP mutations near the γ-secretase cleavage site differentially affect Aβ secretion and APP C-terminal fragment stability
39. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
40. Spatial and temporal transcriptomics reveal microglia-astroglia crosstalk in the amyloid-β plaque cell niche of Alzheimer’s disease
41. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
42. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling
43. Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency
44. Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10
45. The discrepancy between presenilin subcellular localization and [Gamma]-secretase processing of amyloid precursor protein
46. In Vitro Comparison of the Activity Requirements and Substrate Specificity of Human and Triboleum castaneum PINK1 Orthologues
47. PINK1 Kinase Catalytic Activity Is Regulated by Phosphorylation on Serines 228 and 402
48. Mutations in the Intellectual Disability Gene Ube2a Cause Neuronal Dysfunction and Impair Parkin-Dependent Mitophagy
49. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice
50. Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains
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