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1,003 results on '"Cozzi-Lepri, Alessandro"'

1. Pooled analysis of the MANTICO2 and MONET randomized controlled trials comparing drug efficacy for early treatment of COVID-19 during Omicron waves

Author

Mazzotta, Valentina, Mazzaferri, Fulvia, Lanini, Simone, Mirandola, Massimo, Cozzi Lepri, Alessandro, Vergori, Alessandra, Savoldi, Alessia, Santoro, Andrea, Maccarrone, Gaia, Mastrorosa, Ilaria, Simonetti, Omar, Zottis, Federico De, Nicastri, Emanuele, Rosini, Giulia, Rovigo, Laura, Tavernaro, Lorenzo, Sarmati, Loredana, Tascini, Carlo, Girardi, Enrico, Cattelan, Anna Maria, Antinori, Andrea, and Tacconelli, Evelina

Published
2024
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2. Heavily treatment-experienced persons living with HIV currently in care in Italy: characteristics, risk factors, and therapeutic options—the ICONA Foundation cohort study

Author

Lo Caputo, Sergio, Poliseno, Mariacristina, Tavelli, Alessandro, Gagliardini, Roberta, Rusconi, Stefano, Lapadula, Giuseppe, Antinori, Andrea, Francisci, Daniela, Sarmati, Loredana, Gori, Andrea, Spagnuolo, Vincenzo, Ceccherini-Silberstein, Francesca, d'Arminio Monforte, Antonella, and Cozzi-Lepri, Alessandro

Published
2024
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3. EuCARE-hospitalised study protocol: a cohort study of patients hospitalised with COVID-19 in the EuCARE project

Author

Hedberg, Pontus, Varisco, Benedetta, Bai, Francesca, Sönnerborg, Anders, Naucler, Pontus, Pfeifer, Nico, Cozzi-Lepri, Alessandro, Ceccherini-Silberstein, Francesca, Naumovas, Daniel, Drobniewski, Francis, Jensen, Björn-Erik Ole, Toscano, Cristina, Parczewski, Miłosz, Quintanares, Gibran Horemheb Rubio, Mwau, Matilu, Pinto, Jorge A., Incardona, Francesca, Mommo, Chiara, and Marchetti, Giulia

Published
2023
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4. EuCARE-POSTCOVID Study: a multicentre cohort study on long-term post-COVID-19 manifestations

Author

Varisco, Benedetta, Bai, Francesca, De Benedittis, Sara, Tavelli, Alessandro, Cozzi-Lepri, Alessandro, Sala, Matteo, Miraglia, Federica Gaia, Santoro, Maria Mercedes, Ceccherini-Silberstein, Francesca, Shimoni, Yishai, Ravid, Sivan, Kozlovski, Tal, König, Florian, Pfeifer, Nico, Shamsara, Elham, Parczewski, Milosz, Monforte, Antonella d’Arminio, Incardona, Francesca, Mommo, Chiara, and Marchetti, Giulia

Published
2023
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5. Persistent poor clinical outcomes of people living with HIV presenting with AIDS and late HIV diagnosis – results from the ICONA cohort in Italy, 2009-2022

Author

Mondi, Annalisa, Cozzi-Lepri, Alessandro, Tavelli, Alessandro, Cingolani, Antonella, Giacomelli, Andrea, Orofino, Giancarlo, De Girolamo, Gabriella, Pinnetti, Carmela, Gori, Andrea, Saracino, Annalisa, Bandera, Alessandra, Marchetti, Giulia, Girardi, Enrico, Mussini, Cristina, d'Arminio Monforte, Antonella, and Antinori, Andrea

Published
2024
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7. In-hospital mortality during the wild-type, alpha, delta, and omicron SARS-CoV-2 waves: a multinational cohort study in the EuCARE project

Author

Hedberg, Pontus, Parczewski, Milosz, Serwin, Karol, Marchetti, Giulia, Bai, Francesca, Ole Jensen, Björn-Erik, Pereira, Joana P.V., Drobniewski, Francis, Reschreiter, Henrik, Naumovas, Daniel, Ceccherini-Silberstein, Francesca, Rubio Quintanares, Gibran Horemheb, Mwau, Matilu, Toscano, Cristina, König, Florian, Pfeifer, Nico, Zazzi, Maurizio, Fanti, Iuri, Incardona, Francesca, Cozzi-Lepri, Alessandro, Sönnerborg, Anders, and Nauclér, Pontus

Published
2024
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9. Characterization and outcomes of difficult-to-treat patients starting modern first-line ART regimens: Data from the ICONA cohort

Author

Gagliardini, Roberta, Tavelli, Alessandro, Rusconi, Stefano, Lo Caputo, Sergio, Spagnuolo, Vincenzo, Santoro, Maria Mercedes, Costantini, Andrea, Vergori, Alessandra, Maggiolo, Franco, Giacomelli, Andrea, Burastero, Giulia, Madeddu, Giordano, Quiros Roldan, Eugenia, d'Arminio Monforte, Antonella, Antinori, Andrea, and Cozzi-Lepri, Alessandro

Published
2024
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10. Risk of COVID-19 in-hospital mortality in people living with HIV compared to general population according to age and CD4 strata: data from the ICONA network

Author

Giacomelli, Andrea, Gagliardini, Roberta, Tavelli, Alessandro, De Benedittis, Sara, Mazzotta, Valentina, Rizzardini, Giuliano, Mondi, Annalisa, Augello, Matteo, Antinori, Spinello, Vergori, Alessandra, Gori, Andrea, Menozzi, Marianna, Taramasso, Lucia, Fusco, Francesco Maria, De Vito, Andrea, Mancarella, Giulia, Marchetti, Giulia, D'Arminio Monforte, Antonella, Antinori, Andrea, and Cozzi-Lepri, Alessandro

Published
2023
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11. Efficacy of bezlotoxumab in preventing the recurrence of Clostridioides difficile infection: an Italian multicenter cohort study

Author

Meschiari, Marianna, Cozzi-Lepri, Alessandro, Cervo, Adriana, Granata, Guido, Rogati, Carlotta, Franceschini, Erica, Casolari, Stefania, Tatarelli, Paola, Giacobbe, Daniele Roberto, Bassetti, Matteo, Pinna, Simone Mornese, De Rosa, Francesco Giuseppe, Barchiesi, Francesco, Canovari, Benedetta, Lorusso, Carolina, Russo, Giuseppe, Cenderello, Giovanni, Cascio, Antonio, Petrosillo, Nicola, and Mussini, Cristina

Published
2023
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12. SARS-CoV-2 nasopharyngeal viral load in individuals infected with BA.2, compared to Alpha, Gamma, Delta and BA.1 variants: A single-center comparative analysis

Author

Mastrorosa, Ilaria, Cozzi-Lepri, Alessandro, Colavita, Francesca, Lalle, Eleonora, Mazzotta, Valentina, Cimaglia, Claudia, Paulicelli, Jessica, Matusali, Giulia, Fabeni, Lavinia, Carletti, Fabrizio, Rosati, Silvia, Vita, Serena, Giannico, Giuseppina, Piselli, Pierluca, Biliotti, Elisa, Moghazi, Samir Al, Mosti, Silvia, Girardi, Enrico, Nicastri, Emanuele, Garbuglia, Anna Rosa, Maggi, Fabrizio, Vaia, Francesco, and Antinori, Andrea

Published
2022
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13. Observational cohort study of rilpivirine (RPV) utilization in Europe

Author

Cozzi-Lepri, Alessandro, Peters, Lars, Pelchen-Matthews, Annegret, Neesgaard, Bastian, De Wit, Stephane, Johansen, Isik Somuncu, Edwards, Simon, Stephan, Christoph, Adamis, Georgios, Staub, Therese, Zagalo, Alexandra, Domingo, Pere, Elbirt, Daniel, Kusejko, Katharina, Brännström, Johanna, Paduta, Dzmitry, Trofimova, Tatyana, Szlavik, Janos, Zilmer, Kai, Losso, Marcello, Van Eygen, Veerle, Pai, Helen, Lundgren, Jens, and Mocroft, Amanda

Published
2022
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14. Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV

Author

Vergori, Alessandra, Cozzi Lepri, Alessandro, Cicalini, Stefania, Matusali, Giulia, Bordoni, Veronica, Lanini, Simone, Meschi, Silvia, Iannazzo, Roberta, Mazzotta, Valentina, Colavita, Francesca, Mastrorosa, Ilaria, Cimini, Eleonora, Mariotti, Davide, De Pascale, Lydia, Marani, Alessandra, Gallì, Paola, Garbuglia, AnnaRosa, Castilletti, Concetta, Puro, Vincenzo, Agrati, Chiara, Girardi, Enrico, Vaia, Francesco, and Antinori, Andrea

Published
2022
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16. Association between markers of hepatitis B virus infection and risk of virological rebound in people with HIV receiving antiretroviral therapy.

Author

Malagnino, Vincenzo, Cozzi‐Lepri, Alessandro, Svicher, Valentina, Girardi, Enrico, Perno, Carlo Federico, Saracino, Annalisa, Cuomo, Gianluca, Rusconi, Stefano, Puoti, Massimo, D'Arminio Monforte, Antonella, Andreoni, Massimo, and Sarmati, Loredana

Subjects
*RISK assessment, *ANTIRETROVIRAL agents, *VIRAL load, *HIV infections, *DESCRIPTIVE statistics, *LONGITUDINAL method, *RNA, *KAPLAN-Meier estimator, *HEPATITIS B, *SURVIVAL analysis (Biometry), *CONFIDENCE intervals, *DISEASE progression, *MIXED infections, *BIOMARKERS, *PROPORTIONAL hazards models, *DISEASE complications
Abstract

Objectives: The aim of this analysis was to investigate the impact of hepatitis B virus (HBV) coinfection on the risk of HIV viral rebound (VR) after achieving suppression for the first time following initiation of antiretroviral therapy (ART) in the real‐world setting. Design: Patients living with HIV (PLWH) who were enrolled in the ICONA Foundation Study cohort and achieved viral suppression ≤50 copies/mL for the first time after starting ART were prospectively evaluated and divided in three exposure groups according to serology test results: (a) HIV‐monoinfected; (b) HIV‐positive/HBcAb‐positive/HBsAg‐negative; (c) HIV‐positive/HBsAg‐positive. The occurrence of VR, defined as two consecutive HIV‐RNA values >50 copies/mL after achieving viral suppression for the first time (baseline), was investigated. Methods: Standard survival analysis by means of Kaplan–Meier curves and Cox regression analysis with the serology exposure fitted as a time‐fixed covariate measured at baseline was employed after controlling for key confounding factors. Results: Of a total of 5657 patients included, 4090 (72%) were HIV‐monoinfected, 1342 (23.7%)were HBcAb‐positive, and 225 (3.9%) were HbsAg‐positive coinfected. Overall, 654 (11.5%) PLWH experienced VR > 50 copies/mL during follow‐up. After controlling for all sources of measured confounding, coinfected PLWH showed an increased risk of experiencing VR compared with those who were HIV‐monoinfected. In particular, the strongest associations were seen for the HIV/HBsAg‐positive participants [adjusted hazard ratio (aHR) = 1.56, 95% confidence interval (CI): 1.03–2.38, p = 0.037] but an excess of risk was also seen in those who were HIV‐positive/HBcAb‐positive/HBsAg‐negative (aHR = 1.25, 95% CI: 1.00–1.55, p = 0.047). Conclusions: Coinfection with HBV seems to have an impact on the probability of maintaining HIV viral suppression achieved for the first time after ART initiation. Of note, even PLWH positive for HBcAb, a marker of inactive HBV infection, appeared to be at higher risk of VR compared with those who were HIV‐monoinfected and their HIV‐RNA should be carefully monitored. [ABSTRACT FROM AUTHOR]

Published
2024
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17. The Omicron Variant Is Associated with a Reduced Risk of the Post COVID-19 Condition and Its Main Phenotypes Compared to the Wild-Type Virus: Results from the EuCARE-POSTCOVID-19 Study.

Author

Bai, Francesca, Santoro, Andrea, Hedberg, Pontus, Tavelli, Alessandro, De Benedittis, Sara, de Morais Caporali, Júlia Fonseca, Marinho, Carolina Coimbra, Leite, Arnaldo Santos, Santoro, Maria Mercedes, Ceccherini Silberstein, Francesca, Iannetta, Marco, Juozapaité, Dovilé, Strumiliene, Edita, Almeida, André, Toscano, Cristina, Ruiz-Quiñones, Jesús Arturo, Mommo, Chiara, Fanti, Iuri, Incardona, Francesca, and Cozzi-Lepri, Alessandro

Subjects
SARS-CoV-2 Omicron variant, SARS-CoV-2 Delta variant, POST-acute COVID-19 syndrome, SARS-CoV-2, INTENSIVE care units
Abstract

Post COVID-19 condition (PCC) is defined as ongoing symptoms at ≥1 month after acute COVID-19. We investigated the risk of PCC in an international cohort according to viral variants. We included 7699 hospitalized patients in six centers (January 2020–June 2023); a subset of participants with ≥1 visit over the year after clinical recovery were analyzed. Variants were observed or estimated using Global Data Science Initiative (GISAID) data. Because patients returning for a post COVID-19 visit may have a higher PCC risk, and because the variant could be associated with the probability of returning, we used weighted logistic regressions. We estimated the proportion of the effect of wild-type (WT) virus vs. Omicron on PCC, which was mediated by Intensive Care Unit (ICU) admission, through a mediation analysis. In total, 1317 patients returned for a post COVID visit at a median of 2.6 (IQR 1.84–3.97) months after clinical recovery. WT was present in 69.6% of participants, followed by the Alpha (14.4%), Delta (8.9%), Gamma (3.9%) and Omicron strains (3.3%). Among patients with PCC, the most common manifestations were fatigue (51.7%), brain fog (32.7%) and respiratory symptoms (37.2%). Omicron vs. WT was associated with a reduced risk of PCC and PCC clusters; conversely, we observed a higher risk with the Delta and Alpha variants vs. WT. In total, 42% of the WT effect vs. Omicron on PCC risk appeared to be mediated by ICU admission. A reduced PCC risk was observed after Omicron infection, suggesting a possible reduction in the PCC burden over time. A non-negligible proportion of the variant effect on PCC risk seems mediated by increased disease severity during the acute disease. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Factors Associated With Persistence of Plasma HIV-1 RNA During Long-term Continuously Suppressive Firstline Antiretroviral Therapy.

Author

Ruggiero, Alessandra, Cozzi-Lepri, Alessandro, Beloukas, Apostolos, Richman, Douglas, Khoo, Saye, Phillips, Andrew, Geretti, Anna Maria, and ERAS Study Group

Subjects
ERAS Study Group, 2-LTR circular DNA, activation, drug concentration, sCD27, viral load
Abstract

Background:Persistence of plasma HIV-1 RNA during seemingly effective antiretroviral thereapy (ART) is incompletely understood. Using an ultrasensitive assay, this cross-sectional study investigated residual plasma HIV-1 RNA in subjects maintained on firstline ART with continuous viral load suppression

Published
2018

19. Better prognosis in females with severe COVID-19 pneumonia: possible role of inflammation as potential mediator

Author

Bacca, Erica, Bedini, Andrea, Borghi, Vanni, Burastero, Giulia, Carli, Federica, Ciusa, Giacomo, Corradi, Luca, Di Gaetano, Margherita, Faltoni, Matteo, Franceschi, Giacomo, Orlando, Gabriella, Pellegrino, Francesco, Puzzolante, Cinzia, Raimondi, Alessandro, Santoro, Antonella, Tutone, Marco, Yaacoub, Dina, Andreotti, Alberto, Biagioni, Emanuela, Bondi, Filippo, Busani, Stefano, Chierego, Giovanni, Scotti, Marzia, Serio, Lucia, Bellinazzi, Caterina, Borella, Rebecca, De Biasi, Sara, De Gaetano, Anna, Fidanza, Lucia, Gibellini, Lara, Iannone, Anna, Lo Tartaro, Domenico, Mattioli, Marco, Paolini, Annamaria, Fogliani, Rossella, Righini, Grazia, Lugli, Mario, Mussini, Cristina, Cozzi-Lepri, Alessandro, Menozzi, Marianna, Meschiari, Marianna, Franceschini, Erica, Rogati, Carlotta, Cuomo, Gianluca, Iadisernia, Vittorio, Volpi, Sara, Milic, Jovana, Tonelli, Roberto, Brugioni, Lucio, Pietrangelo, Antonello, Girardis, Massimo, Cossarizza, Andrea, Clini, Enrico, and Guaraldi, Giovanni

Published
2021
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20. Comparison of Kaposi Sarcoma Risk in Human Immunodeficiency Virus-Positive Adults Across 5 Continents: A Multiregional Multicohort Study

Author

Judd, Ali, Zangerle, Robert, Touloumi, Giota, Warszawski, Josiane, Meyer, Laurence, Dabis, François, Krause, Murielle Mary, Ghosn, Jade, Leport, Catherine, Wittkop, Linda, Reiss, Peter, Wit, Ferdinand, Prins, Maria, Bucher, Heiner, Gibb, Diana, Fätkenheuer, Gerd, Julia, Del Amo, Obel, Niels, Thorne, Claire, Mocroft, Amanda, Kirk, Ole, Stephan, Christoph, Pérez-Hoyos, Santiago, Hamouda, Osamah, Bartmeyer, Barbara, Chkhartishvili, Nikoloz, Noguera-Julian, Antoni, Antinori, Andrea, Monforte, Antonella d’Arminio, Brockmeyer, Norbert, Prieto, Luis, Conejo, Pablo Rojo, Soriano-Arandes, Antoni, Battegay, Manuel, Kouyos, Roger, Mussini, Cristina, Tookey, Pat, Casabona, Jordi, Miró, Jose M, Castagna, Antonella, Konopnick, Deborah, Goetghebuer, Tessa, Sönnerborg, Anders, Quiros-Roldan, Eugenia, Sabin, Caroline, Teira, Ramon, Garrido, Myriam, Haerry, David, de Wit, Stéphane, Costagliola, Dominique, d’Arminio-Monforte, Antonella, del Amo, Julia, Raben, Dorthe, Chêne, Geneviève, Rojo, Conejo Pablo, Barger, Diana, Schwimmer, Christine, Termote, Monique, Campbell, Maria, Frederiksen, Casper M, Friis-Møller, Nina, Kjaer, Jesper, Brandt, Rikke Salbøl, Berenguer, Juan, Bohlius, Julia, Bouteloup, Vincent, Cozzi-Lepri, Alessandro, Davies, Mary-Anne, Dorrucci, Maria, Dunn, David, Egger, Matthias, Furrer, Hansjakob, Grabar, Sophie, Guiguet, Marguerite, Lambotte, Olivier, Leroy, Valériane, Lodi, Sara, Matheron, Sophie, Miro, Jose M, Monge, Susana, Nakagawa, Fumiyo, Paredes, Roger, Phillips, Andrew, Puoti, Massimo, Rohner, Eliane, and Schomaker, Michael

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Sexually Transmitted Infections, Rare Diseases, Emerging Infectious Diseases, Infectious Diseases, HIV/AIDS, Infection, Adolescent, Adult, Anti-Retroviral Agents, CD4 Lymphocyte Count, Cohort Studies, Female, HIV Infections, HIV-1, Humans, Male, Middle Aged, Risk Factors, Sarcoma, Kaposi, Viral Load, Young Adult, AIDS-defining Cancer Project Working Group for IeDEA and COHERE in EuroCoord, HIV, Kaposi sarcoma, antiretroviral therapy, cohort study, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundWe compared Kaposi sarcoma (KS) risk in adults who started antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America.MethodsWe included cohort data of human immunodeficiency virus (HIV)-positive adults who started ART after 1995 within the framework of 2 large collaborations of observational HIV cohorts. We present incidence rates and adjusted hazard ratios (aHRs).ResultsWe included 208140 patients from 57 countries. Over a period of 1066572 person-years, 2046 KS cases were diagnosed. KS incidence rates per 100000 person-years were 52 in the Asia-Pacific and ranged between 180 and 280 in the other regions. KS risk was 5 times higher in South African women (aHR, 4.56; 95% confidence intervals [CI], 2.73-7.62) than in their European counterparts, and 2 times higher in South African men (2.21; 1.34-3.63). In Europe, Latin, and North America KS risk was 6 times higher in men who have sex with men (aHR, 5.95; 95% CI, 5.09-6.96) than in women. Comparing patients with current CD4 cell counts ≥700 cells/µL with those whose counts were

Published
2017

21. Using observational data to emulate a randomized trial of dynamic treatment-switching strategies: an application to antiretroviral therapy

Author

Cain, Lauren E, Saag, Michael S, Petersen, Maya, May, Margaret T, Ingle, Suzanne M, Logan, Roger, Robins, James M, Abgrall, Sophie, Shepherd, Bryan E, Deeks, Steven G, Gill, M John, Touloumi, Giota, Vourli, Georgia, Dabis, François, Vandenhende, Marie-Anne, Reiss, Peter, van Sighem, Ard, Samji, Hasina, Hogg, Robert S, Rybniker, Jan, Sabin, Caroline A, Jose, Sophie, del Amo, Julia, Moreno, Santiago, Rodríguez, Benigno, Cozzi-Lepri, Alessandro, Boswell, Stephen L, Stephan, Christoph, Pérez-Hoyos, Santiago, Jarrin, Inma, Guest, Jodie L, Monforte, Antonella D’Arminio, Antinori, Andrea, Moore, Richard, Campbell, Colin NJ, Casabona, Jordi, Meyer, Laurence, Seng, Rémonie, Phillips, Andrew N, Bucher, Heiner C, Egger, Matthias, Mugavero, Michael J, Haubrich, Richard, Geng, Elvin H, Olson, Ashley, Eron, Joseph J, Napravnik, Sonia, Kitahata, Mari M, Van Rompaey, Stephen E, Teira, Ramón, Justice, Amy C, Tate, Janet P, Costagliola, Dominique, Sterne, Jonathan AC, Hernán, Miguel A, and Systems, and the HIV-CAUSAL Collaboration on behalf of the Antiretroviral Therapy Cohort Collaboration the Centers for AIDS Research Network of Integrated Clinical

Subjects
Epidemiology, Health Sciences, Clinical Trials and Supportive Activities, Infectious Diseases, Sexually Transmitted Infections, HIV/AIDS, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Good Health and Well Being, Adult, Anti-HIV Agents, CD4 Lymphocyte Count, Female, HIV Infections, HIV-1, Humans, Male, Middle Aged, Observational Studies as Topic, Randomized Controlled Trials as Topic, Survival Analysis, United Kingdom, Viral Load, HIV, antiretroviral therapy, inverse-probability weighting, observational studies, mortality, dynamic strategies, Antiretroviral Therapy Cohort Collaboration, the Centers for AIDS Research Network of Integrated Clinical Systems, and the HIV-CAUSAL Collaboration, Statistics, Public Health and Health Services, Public health
Abstract

BackgroundWhen a clinical treatment fails or shows suboptimal results, the question of when to switch to another treatment arises. Treatment switching strategies are often dynamic because the time of switching depends on the evolution of an individual's time-varying covariates. Dynamic strategies can be directly compared in randomized trials. For example, HIV-infected individuals receiving antiretroviral therapy could be randomized to switching therapy within 90 days of HIV-1 RNA crossing above a threshold of either 400 copies/ml (tight-control strategy) or 1000 copies/ml (loose-control strategy).MethodsWe review an approach to emulate a randomized trial of dynamic switching strategies using observational data from the Antiretroviral Therapy Cohort Collaboration, the Centers for AIDS Research Network of Integrated Clinical Systems and the HIV-CAUSAL Collaboration. We estimated the comparative effect of tight-control vs. loose-control strategies on death and AIDS or death via inverse-probability weighting.ResultsOf 43 803 individuals who initiated an eligible antiretroviral therapy regimen in 2002 or later, 2001 met the baseline inclusion criteria for the mortality analysis and 1641 for the AIDS or death analysis. There were 21 deaths and 33 AIDS or death events in the tight-control group, and 28 deaths and 41 AIDS or death events in the loose-control group. Compared with tight control, the adjusted hazard ratios (95% confidence interval) for loose control were 1.10 (0.73, 1.66) for death, and 1.04 (0.86, 1.27) for AIDS or death.ConclusionsAlthough our effective sample sizes were small and our estimates imprecise, the described methodological approach can serve as an example for future analyses.

Published
2016

23. Discrimination of the Veterans Aging Cohort Study Index 2.0 for Predicting Cause-specific Mortality Among Persons With HIV in Europe and North America.

Author

Ambia, Julie, Ingle, Suzanne M, McGinnis, Kathleen, Pantazis, Nikos, Silverberg, Michael J, Wittkop, Linda, Kusejko, Katharina, Crane, Heidi, Sighem, Ard van, Sarcletti, Mario, Cozzi-Lepri, Alessandro, Domingo, Pere, Jarrin, Inma, Wyen, Christoph, Hessamfar, Mojgan, Zhang, Lei, Cavassini, Matthias, Berenguer, Juan, Sterling, Timothy R, and Reiss, Peter

Subjects
AGE discrimination, SURVIVAL analysis (Biometry), DEATH rate, ANTIRETROVIRAL agents, MORTALITY
Abstract

Background Predicting cause-specific mortality among people with HIV (PWH) could facilitate targeted care to improve survival. We assessed discrimination of the Veterans Aging Cohort Study (VACS) Index 2.0 in predicting cause-specific mortality among PWH on antiretroviral therapy (ART). Methods Using Antiretroviral Therapy Cohort Collaboration data for PWH who initiated ART between 2000 and 2018, VACS Index 2.0 scores (higher scores indicate worse prognosis) were calculated around a randomly selected visit date at least 1 year after ART initiation. Missingness in VACS Index 2.0 variables was addressed through multiple imputation. Cox models estimated associations between VACS Index 2.0 and causes of death, with discrimination evaluated using Harrell's C-statistic. Absolute mortality risk was modelled using flexible parametric survival models. Results Of 59 741 PWH (mean age: 43 years; 80% male), the mean VACS Index 2.0 at baseline was 41 (range: 0–129). For 2425 deaths over 168 162 person-years follow-up (median: 2.6 years/person), AIDS (n = 455) and non–AIDS-defining cancers (n = 452) were the most common causes. Predicted 5-year mortality for PWH with a mean VACS Index 2.0 score of 38 at baseline was 1% and approximately doubled for every 10-unit increase. The 5-year all-cause mortality C-statistic was.83. Discrimination with the VACS Index 2.0 was highest for deaths resulting from AIDS (0.91), liver-related (0.91), respiratory-related (0.89), non-AIDS infections (0.87), and non–AIDS-defining cancers (0.83), and lowest for suicides/accidental deaths (0.65). Conclusions For deaths among PWH, discrimination with the VACS Index 2.0 was highest for deaths with measurable physiological causes and was lowest for suicide/accidental deaths. [ABSTRACT FROM AUTHOR]

Published
2024
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24. The importance of patients’ case-mix for the correct interpretation of the hospital fatality rate in COVID-19 disease

Author

d’Arminio Monforte, Antonella, Tavelli, Alessandro, Bai, Francesca, Tomasoni, Daniele, Falcinella, Camilla, Castoldi, Roberto, Barbanotti, Diletta, Mulè, Giovanni, Allegrini, Marina, Tesoro, Daniele, Tagliaferri, Gianmarco, Mondatore, Debora, Augello, Matteo, Cona, Andrea, Ancona, Giuseppe, Gazzola, Lidia, Iannotti, Nathalie, Tincati, Camilla, Viganò, Ottavia, De Bona, Anna, Bini, Teresa, Cozzi-Lepri, Alessandro, and Marchetti, Giulia

Published
2020
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25. Tocilizumab in patients with severe COVID-19: a retrospective cohort study

Author

Guaraldi, Giovanni, Meschiari, Marianna, Cozzi-Lepri, Alessandro, Milic, Jovana, Tonelli, Roberto, Menozzi, Marianna, Franceschini, Erica, Cuomo, Gianluca, Orlando, Gabriella, Borghi, Vanni, Santoro, Antonella, Di Gaetano, Margherita, Puzzolante, Cinzia, Carli, Federica, Bedini, Andrea, Corradi, Luca, Fantini, Riccardo, Castaniere, Ivana, Tabbì, Luca, Girardis, Massimo, Tedeschi, Sara, Giannella, Maddalena, Bartoletti, Michele, Pascale, Renato, Dolci, Giovanni, Brugioni, Lucio, Pietrangelo, Antonello, Cossarizza, Andrea, Pea, Federico, Clini, Enrico, Salvarani, Carlo, Massari, Marco, Viale, Pier Luigi, and Mussini, Cristina

Published
2020
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27. Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy

Author

Grund, Birgit, Baker, Jason V, Deeks, Steven G, Wolfson, Julian, Wentworth, Deborah, Cozzi-Lepri, Alessandro, Cohen, Calvin J, Phillips, Andrew, Lundgren, Jens D, and Neaton, James D

Subjects
Biomedical and Clinical Sciences, Public Health, Health Sciences, HIV/AIDS, Clinical Research, Infectious Diseases, Prevention, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Adult, Antiretroviral Therapy, Highly Active, Biomarkers, C-Reactive Protein, Endpoint Determination, Female, Fibrin Fibrinogen Degradation Products, HIV Seropositivity, Humans, Interleukin-6, Kaplan-Meier Estimate, Male, Middle Aged, Morbidity, Risk Reduction Behavior, INSIGHT SMART/ESPRIT/SILCAAT Study Group, General Science & Technology
Abstract

BackgroundDespite effective antiretroviral treatment (ART), HIV-positive individuals are at increased risk of serious non-AIDS conditions (cardiovascular, liver and renal disease, and cancers), perhaps due in part to ongoing inflammation and/or coagulation. To estimate the potential risk reduction in serious non-AIDS conditions or death from any cause that might be achieved with treatments that reduce inflammation and/or coagulation, we examined associations of interleukin-6 (IL-6), D-dimer, and high-sensitivity C-reactive protein (hsCRP) levels with serious non-AIDS conditions or death in 3 large cohorts.MethodsIn HIV-positive adults on suppressive ART, associations of IL-6, D-dimer, and hsCRP levels at study entry with serious non-AIDS conditions or death were studied using Cox regression. Hazard ratios (HR) adjusted for age, gender, study, and regression dilution bias (due to within-person biomarker variability) were used to predict risk reductions in serious non-AIDS conditions or death associated with lower "usual" levels of IL-6 and D-dimer.ResultsOver 4.9 years of mean follow-up, 260 of the 3766 participants experienced serious non-AIDS conditions or death. IL-6, D-dimer and hsCRP were each individually associated with risk of serious non-AIDS conditions or death, HR = 1.45 (95% CI: 1.30 to 1.63), 1.28 (95% CI: 1.14 to 1.44), and 1.17 (95% CI: 1.09 to 1.26) per 2x higher biomarker levels, respectively. In joint models, IL-6 and D-dimer were independently associated with serious non-AIDS conditions or death, with consistent results across the 3 cohorts and across serious non-AIDS event types. The association of IL-6 and D-dimer with serious non-AIDS conditions or death was graded and persisted throughout follow-up. For 25% lower "usual" IL-6 and D-dimer levels, the joint biomarker model estimates a 37% reduction (95% CI: 28 to 46%) in the risk of serious non-AIDS conditions or death if the relationship is causal.ConclusionsBoth IL-6 and D-dimer are independently associated with serious non-AIDS conditions or death among HIV-positive adults with suppressed virus. This suggests that treatments that reduce IL-6 and D-dimer levels might substantially decrease morbidity and mortality in patients on suppressive ART. Clinical trials are needed to test this hypothesis.

Published
2016

32. During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ

Author

Ruggiero, Alessandra, De Spiegelaere, Ward, Cozzi-Lepri, Alessandro, Kiselinova, Maja, Pollakis, Georgios, Beloukas, Apostolos, Vandekerckhove, Linos, Strain, Matthew, Richman, Douglas, Phillips, Andrew, Geretti, Anna Maria, Group, ERAS Study, Vitiello, Paola, Mackie, Nicola, Ainsworth, Jonathan, Waters, Anele, Post, Frank, Edwards, Simon, and Fox, Julie

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, HIV/AIDS, Genetics, Clinical Research, Infectious Diseases, Infection, Adult, Antiretroviral Therapy, Highly Active, CD8-Positive T-Lymphocytes, DNA, Viral, Female, HIV-1, HLA-DP Antigens, HLA-DQ Antigens, HLA-DR Antigens, Humans, Linear Models, Male, Middle Aged, Multivariate Analysis, Viral Load, Suppression, Reservoir, Persistence, Integration, Activation, ERAS Study Group, 2-LTR, 2-long terminal repeats, ART, Anti-retroviral therapy, CMV, cytomegalovirus virus, CRN, Clinical Research Network, EBV, Epstein-Bar virus, ELISA, enzyme-linked immune-enzymatic assay, HIC, HIV-1 controllers, HIV-1 VL, HIV-1 viral load, HIV-1, Human Immunodeficiency Virus type 1, HLA, Human Leukocyte Antigen, LPS, lipopolysaccharide, NIHR, National Institute for Health Research, NNRTI, Non-nucleoside reverse-transcriptase inhibitors, NRTI, nucleoside/nucleotide reverse transcriptase inhibitors, PBMCs, Peripheral blood mononuclear cells, PCR, Polymerase chain reaction, PFA, paraformaldehyde, VLS, Viral Load Suppression, WHO, World Health Organisation, sCD14, soluble CD14, Clinical Sciences, Public Health and Health Services, Clinical sciences, Epidemiology
Abstract

BackgroundCharacterising the correlates of HIV persistence improves understanding of disease pathogenesis and guides the design of curative strategies. This study investigated factors associated with integrated HIV-1 DNA load during consistently suppressive first-line antiretroviral therapy (ART).MethodTotal, integrated, and 2-long terminal repeats (LTR) circular HIV-1 DNA, residual plasma HIV-1 RNA, T-cell activation markers, and soluble CD14 (sCD14) were measured in peripheral blood of 50 patients that had received 1-14 years of efavirenz-based or nevirapine-based therapy.ResultsIntegrated HIV-1 DNA load (per 10(6) peripheral blood mononuclear cells) was median 1.9 log10 copies (interquartile range 1.7-2.2) and showed a mean difference of 0.2 log10 copies per 10 years of suppressive ART (95% confidence interval - 0.2, 0.6; p = 0.28). It was positively correlated with total HIV-1 DNA load and frequency of CD8(+)HLA-DR/DP/DQ(+) cells, and was also higher in subjects with higher sCD14 levels, but showed no correlation with levels of 2-LTR circular HIV-1 DNA and residual plasma HIV-1 RNA, or the frequency of CD4(+)CD38(+) and CD8(+)CD38(+) cells. Adjusting for pre-ART viral load, duration of suppressive ART, CD4 cell counts, residual plasma HIV-1 RNA levels, and sCD14 levels, integrated HIV-1 DNA load was mean 0.5 log10 copies higher for each 50% higher frequency of CD8(+)HLA-DR/DP/DQ(+) cells (95% confidence interval 0.2, 0.9; p = 0.01).ConclusionsThe observed positive association between integrated HIV-1 DNA load and frequency of CD8(+)DR/DP/DQ(+) cells indicates that a close correlation between HIV persistence and immune activation continues during consistently suppressive therapy. The inducers of the distinct activation profile warrant further investigation.

Published
2015

33. Development and validation of a prediction score for failure to casirivimab/imdevimab in hospitalized patients with COVID-19 pneumonia.

Author

Cozzi-Lepri, Alessandro, Borghi, Vanni, Rotundo, Salvatore, Mariani, Bianca, Ferrari, Anna, Borgo, Cosmo Del, Bai, Francesca, Colletti, Pietro, Miraglia, Piermauro, Torti, Carlo, Cattelan, Anna Maria, Cenderello, Giovanni, Berruti, Marco, Tascini, Carlo, Parruti, Giustino, Coladonato, Simona, Gori, Andrea, Marchetti, Giulia, Lichtner, Miriam, and Coppola, Luigi

Published
2024
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34. Long Term Assessment of Anti-SARS-CoV-2 Immunogenicity after mRNA Vaccine in Persons Living with HIV

Author

Vergori, Alessandra, primary, Cozzi-Lepri, Alessandro, additional, Matusali, Giulia, additional, Cicalini, Stefania, additional, Bordoni, Veronica, additional, Meschi, Silvia, additional, Mazzotta, Valentina, additional, Colavita, Francesca, additional, Fusto, Marisa, additional, Cimini, Eleonora, additional, Notari, Stefania, additional, D’Aquila, Veronica, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Gagliardini, Roberta, additional, Mariotti, Davide, additional, Giannico, Giuseppina, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, Agrati, Chiara, additional, Maggi, Fabrizio, additional, and Antinori, Andrea, additional

Published
2023
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35. Evaluating immunological and inflammatory changes of treatment-experienced people living with HIV switching from first-line triple cART regimens to DTG/3TC vs. B/F/TAF: the DEBATE trial

Author

Cossarizza, Andrea, primary, Cozzi-Lepri, Alessandro, additional, Mattioli, Marco, additional, Paolini, Annamaria, additional, Neroni, Anita, additional, De Biasi, Sara, additional, Tartaro, Domenico Lo, additional, Borella, Rebecca, additional, Fidanza, Lucia, additional, Gibellini, Lara, additional, Beghetto, Barbara, additional, Roncaglia, Enrica, additional, Nardini, Giulia, additional, Milic, Jovana, additional, Menozzi, Marianna, additional, Cuomo, Gianluca, additional, Digaetano, Margherita, additional, Orlando, Gabriella, additional, Borghi, Vanni, additional, Guaraldi, Giovanni, additional, and Mussini, Cristina, additional

Published
2023
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36. Long Term Assessment of Anti-SARS-CoV-2 Immunogenicity after mRNA Vaccine in PLWH

Author

Vergori, Alessandra, primary, Cozzi-Lepri, Alessandro, additional, Matusali, Giulia, additional, Cicalini, Stefania, additional, Bordoni, Veronica, additional, Meschi, Silvia, additional, Mazzotta, Valentina, additional, Colavita, Francesca, additional, Fusto, Marisa, additional, Cimini, Eleonora, additional, Notari, Stefania, additional, D'Aquila, Veronica, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Gagliardini, Roberta, additional, Mariotti, Davide, additional, Giannico, Giuseppina, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, Agrati, Chiara, additional, Maggi, Fabrizio, additional, and Antinori, Andrea, additional

Published
2023
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37. EuCARE-HOSPITALISED Study Protocol: A Cohort Study of Patients Hospitalised with COVID-19 in the EuCARE Project

Author

Hedberg, Pontus, primary, Varisco, Benedetta, additional, Bai, Francesca, additional, Sönnerborg, Anders, additional, Naucler, Pontus, additional, Pfeifer, Nico, additional, Cozzi-Lepri, Alessandro, additional, Ceccherini-Silberstein, Francesca, additional, Naumovas, Daniel, additional, Drobniewski, Francis, additional, Jensen, Björn-Erik Ole, additional, Toscano, Cristina, additional, Parczewski, Miłosz, additional, Quintanares, Gibran Horemheb Rubio, additional, Mwau, Matilu, additional, Pinto, Jorge A., additional, Incardona, Francesca, additional, Mommo, Chiara, additional, and Marchetti, Giulia, additional

Published
2023
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38. Characterization and outcomes of difficult-to-treat patients starting modern first-line ART regimens: data from the ICONA cohort

Author

Gagliardini, Roberta, primary, Tavelli, Alessandro, additional, Rusconi, Stefano, additional, Lo Caputo, Sergio, additional, Spagnuolo, Vincenzo, additional, Santoro, Maria Mercedes, additional, Costantini, Andrea, additional, Vergori, Alessandra, additional, Maggiolo, Franco, additional, Giacomelli, Andrea, additional, Burastero, Giulia, additional, Madeddu, Giordano, additional, Quiros Roldan, Eugenia, additional, d'Arminio Monforte, Antonella, additional, Antinori, Andrea, additional, and Cozzi-Lepri, Alessandro, additional

Published
2023
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39. Long-acting combination of cabotegravir plus rilpivirine: A picture of potential eligible and ineligible HIV-positive individuals from the Italian ARCA cohort

Author

Cervo, Adriana, primary, Russo, Antonio, additional, Di Carlo, Domenico, additional, De Vito, Andrea, additional, Fabeni, Lavinia, additional, D'Anna, Stefano, additional, Duca, Leonardo, additional, Colpani, Agnese, additional, Fois, Marco, additional, Zauli, Beatrice, additional, Mancarella, Giulia, additional, Carraro, Anna, additional, Bezenchek, Antonia, additional, Cozzi-Lepri, Alessandro, additional, and Santoro, Maria Mercedes, additional

Published
2023
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41. Risk of SARS-CoV-2 infection in patients with hematologic diseases receiving tixagevimab/cilgavimab as pre-exposure prophylaxis in most recent Omicron sublineages era

Author

Vergori, Alessandra, Cozzi Lepri, Alessandro, Chiuchiarelli, Marta, Mazzotta, Valentina, Metafuni, Elisabetta, Matusali, Giulia, Siciliano, Valentina, Paulicelli, Jessica, Alma, Eleonora, Siniscalchi, Agostina, Sica, Simona, Abruzzese, Elisabetta, Fantoni, Massimo, Antinori, Andrea, and Cingolani, Antonella

Published
2024
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42. SARS-CoV-2 mRNA vaccination and short-term changes in viral load and CD4/CD8 T-cell counts in people living with HIV

Author

Vergori, Alessandra, Cozzi-Lepri, Alessandro, Tavelli, Alessandro, Mazzotta, Valentina, Azzini, Anna Maria, Gagliardini, Roberta, Mastrorosa, Ilaria, Latini, Alessandra, Pellicanò, Giovanni, Taramasso, Lucia, Ceccherini-Silberstein, Francesca, Giannella, Maddalena, Tacconelli, Evelina, Marchetti, Giulia, Monforte, Antonella d'Arminio, and Antinori, Andrea

Published
2024
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43. Prevalence and Outcomes for Heavily Treatment-Experienced Individuals Living With Human Immunodeficiency Virus in a European Cohort

Author

Pelchen-Matthews, Annegret, Borges, Álvaro H., Reekie, Joanne, Rasmussen, Line D., Wiese, Lothar, Weber, Jonathan, Pradier, Christian, Degen, Olaf, Paredes, Roger, Tau, Luba, Flamholc, Leo, Gottfredsson, Magnus, Kowalska, Justyna, Jablonowska, Elzbieta, Mozer-Lisewska, Iwona, Radoi, Roxana, Vasylyev, Marta, Kuznetsova, Anastasiia, Begovac, Josip, Svedhem, Veronica, Clark, Andrew, and Cozzi-Lepri, Alessandro

Published
2021
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44. Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial

Author

Jensen, Jens-Ulrik Stæhr, Itenov, Theis Skovsgaard, Johansen, Maria Egede, Lundgren, Jens, Tønnesen, Else, Bestle, Morten, Lindhardt, Anne, Christensen, Henrik, Planck Pedersen, Henrik, Poulsen, Lone Musaeus, Cozzi-Lepri, Alessandro, Illkjær, Susanne, Soni, Uday Kant, Møller, Kirsten, Juffermans, Nicole P, Sessler, Daniel I, Mohr, Thomas, Masur, Henry, Torp-Pedersen, Christian, Copas, Andrew, Nielsen, Birgit Riis, Kristensen, Dennis Karsten, Grarup, Jesper, Hansen, Jette, Nielsen, Kim, Valbjørn, Lone, Lauritzen, Sanne, Kold, Tina, Grundahl, Kathrine, Hein, Lars, Rasmussen, Rikke Hein, Wesche, Nikolaj, Blom, Hasse, Jensen, Peer Eske, Galle, Tina, Thaarslund, Bente, Skandov, Camilla, Langholz, Iben, Skram, Ulrik, Berthelsen, Rasmus Ehrenfried, Kjær, Dorthe, Uldbjerg, Merete, Lipsius, Lily, Gyldensted, Louise, Engsig, Magaly, Helsted, Rikke, Andersen, Birgitte, Nygaard, Eigil, Strande, Søren, Bangash, Aimal Khan, Waldau, Tina, Søe-Jensen, Peter, Tousi, Hamid, Tangager, Malene, Hagi-Pedersen, Daniel, Gatz, Rainer Karl-Heinz, Engen, Marte Kaasen, Wamberg, Christian Åge, Westergaard, Bo, Harmon, Matthew, Thormar, Katrin, Stoktoft, Stine, Scherwin, Rebecca, Bærentzen, Finn, Lauritzen, Marlene, Pott, Frank, Bruun, Christina, Meyhoff, Christian, Strange, Ditte Gry, Palmqvist, Dorthe Fris, Hemmingsen, Claus, Gärtner, Rune, Petersen, John Asger, Jung, Kai Dieter, La Porte, Louise, Viuf, Mette, Troglauer, Johannes, Borovnjak, Silva, Strandkjær, Nina, Bretlau, Claus, Hansen, Marianna, Zaulich, Lea Kielsgaard, Overgaard, Christian, Bergenholtz, Katja, Jansen, Tejs, Bæk-Jensen, Mette Astrup, Detlefsen, Monika, Albrechtsen, Tannie Lund, Sode, Birgitte Margareta, Boesen, Hans Christian, Thostrup, Maria, Estrup, Stine, Andersen, Torben Mogens, Kjelsteen, Katrine, Winther Kjær, Cilia Klara, Haunstrup, Elsebeth, Christensen, Ole, Spliid, Lone, Rasmussen, Birgitte, Jejlskov, Henriette, Borchorst, Søren, Abdel-Wahab, Akil Walli Raad, Brysting, Marianne, Victor, Jette, Stensbirk, Anette, Bjerregaard, Karen, Poulsen, Anne, Roed, Annette Brix, Bech, Bianca, Perez-Protto, Silvia, Yilmaz, Oguz, Ahuja, Sanchit, Suleiman, Iman, Iglesias, Rodrigo, Breum, Olena, Pedersen, Henrik Planck, Wesche, Nicolai, Strange, Ditte, Lundgren, Jens D, and Jensen, Jens-Ulrik

Published
2018
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45. Common genetic variation and the control of HIV-1 in humans.

Author

Fellay, Jacques, Ge, Dongliang, Shianna, Kevin V, Colombo, Sara, Ledergerber, Bruno, Cirulli, Elizabeth T, Urban, Thomas J, Zhang, Kunlin, Gumbs, Curtis E, Smith, Jason P, Castagna, Antonella, Cozzi-Lepri, Alessandro, De Luca, Andrea, Easterbrook, Philippa, Günthard, Huldrych F, Mallal, Simon, Mussini, Cristina, Dalmau, Judith, Martinez-Picado, Javier, Miro, José M, Obel, Niels, Wolinsky, Steven M, Martinson, Jeremy J, Detels, Roger, Margolick, Joseph B, Jacobson, Lisa P, Descombes, Patrick, Antonarakis, Stylianos E, Beckmann, Jacques S, O'Brien, Stephen J, Letvin, Norman L, McMichael, Andrew J, Haynes, Barton F, Carrington, Mary, Feng, Sheng, Telenti, Amalio, Goldstein, David B, and NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)

Subjects
NIAID Center for HIV/AIDS Vaccine Immunology, Humans, HIV-1, HIV Infections, Disease Progression, Viral Load, Major Histocompatibility Complex, Genotype, Phenotype, Polymorphism, Single Nucleotide, Alleles, Adult, Female, Male, Genetic Variation, Kaplan-Meier Estimate, Polymorphism, Single Nucleotide, Genetics, Developmental Biology
Abstract

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.

Published
2009

46. EuCARE-POSTCOVID Study: A Multicentre Cohort Study on Long-Term Post-COVID-19 Manifestations

Author

Varisco, Benedetta, primary, Bai, Francesca, additional, De Benedittis, Sara, additional, Tavelli, Alessandro, additional, Cozzi-Lepri, Alessandro, additional, Sala, Matteo, additional, Miraglia, Federica Gaia, additional, Santoro, Maria Mercedes, additional, Ceccherini-Silberstein, Francesca, additional, Shimoni, Yishai, additional, Ravid, Sivan, additional, Kozlovski, Tal, additional, Köning, Florian, additional, Pfeifer, Nico, additional, Mommo, Chiara, additional, and Marchetti, Giulia, additional

Published
2023
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47. Effect of tecovirimat on healing time and viral clearance by emulation of a target trial in patients hospitalized for mpox

Author

Mazzotta, Valentina, primary, Cozzi‐Lepri, Alessandro, additional, Lanini, Simone, additional, Mondi, Annalisa, additional, Carletti, Fabrizio, additional, Tavelli, Alessandro, additional, Gagliardini, Roberta, additional, Vita, Serena, additional, Pinnetti, Carmela, additional, Aguglia, Camilla, additional, Colavita, Francesca, additional, Faccendini, Paolo, additional, Matusali, Giulia, additional, Faraglia, Francesca, additional, Beccacece, Alessia, additional, Paulicelli, Jessica, additional, Girardi, Enrico, additional, Nicastri, Emanuele, additional, Vaia, Francesco, additional, Maggi, Fabrizio, additional, and Antinori, Andrea, additional

Published
2023
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48. Machine learning can identify newly diagnosed patients with CLL at high risk of infection

Author

Agius, Rudi, Brieghel, Christian, Andersen, Michael A., Pearson, Alexander T., Ledergerber, Bruno, Cozzi-Lepri, Alessandro, Louzoun, Yoram, Andersen, Christen L., Bergstedt, Jacob, von Stemann, Jakob H., Jørgensen, Mette, Tang, Man-Hung Eric, Fontes, Magnus, Bahlo, Jasmin, Herling, Carmen D., Hallek, Michael, Lundgren, Jens, MacPherson, Cameron Ross, Larsen, Jan, and Niemann, Carsten U.

Published
2020
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49. Issues related to the management of HIV disease in the era of potent HIV antiretroviral therapy : evidence from observational cohort studies of HIV-infected individuals

Author

Cozzi-Lepri, Alessandro

Subjects
616.9792061
Abstract

The aim of this thesis is to present analyses related to the effect of Highly Active Antiretroviral Therapy (HAART) on the natural history of HIV disease after its introduction in the mid- to late-1990s. Analyses have been carried out predominantly on two large observational studies, the Italian Cohort of patients Naive from Antiretrovirals (I.Co.N.A.) and the UNI-clinic of Frankfurt. Several possible ways of defining virological outcomes have been described. Particular importance has been placed on the analytical problems encountered with missing viral load data. A specific approach modelling the time to therapeutic failure was compared with other commonly used approaches and its advantages and disadvantages have been discussed. A number of these methods were then used to focus on several HAART-related issues. The virological and immunological response to HAART was evaluated in the two cohorts, a general description of these responses was given and relevant predictors were identified. More specific analyses have been carried out to describe the limitations of HAART due to toxicity, to describe the prognostic value of viral load measured at 4 and 8 weeks after starting HAART in predicting the week 24 virological response, and to investigate the prevalence of drug-resistance and its role in predicting virological failure. In addition, analyses have been carried out to describe the frequency and predictive value of low level viral rebounds, to investigate the best time to start HAART, and to compare specific drug regimens. Methodologically, this thesis demonstrates the flexibility and usefulness of survival analysis when used in the context of a "time to therapy failure" approach. All the analyses presented emphasise the value of observational studies in providing data that have important implications in clinical practice and for the treatment of people infected with HIV.

Published
2003

50. Rate of response to initial antiretroviral therapy according to level of pre‐existing HIV‐1 drug resistance detected by next‐generation sequencing in the strategic timing of antiretroviral treatment (START) study.

Author

Cozzi‐Lepri, Alessandro, Dunn, David, Tostevin, Anna, Marvig, Rasmus L., Bennedbæk, Marc, Sharma, Shweta, Kozal, Michael J., Gompels, Mark, Pinto, Angie N., Lundgren, Jens, and Baxter, John D.

Subjects
*RNA analysis, *THERAPEUTIC use of protease inhibitors, *HIV infections, *SEQUENCE analysis, *GENETIC mutation, *HIV integrase inhibitors, *CONFIDENCE intervals, *VIRAL load, *ANTIRETROVIRAL agents, *DRUG resistance, *TREATMENT failure, *GENOTYPES, *DISEASE susceptibility, *SURVIVAL analysis (Biometry), *NON-nucleoside reverse transcriptase inhibitors, *DESCRIPTIVE statistics, *RESEARCH funding, *PROPORTIONAL hazards models
Abstract

Objectives: The main objective of this analysis was to evaluate the impact of pre‐existing drug resistance by next‐generation sequencing (NGS) on the risk of treatment failure (TF) of first‐line regimens in participants enrolled in the START study. Methods: Stored plasma from participants with entry HIV RNA >1000 copies/mL were analysed using NGS (llumina MiSeq). Pre‐existing drug resistance was defined using the mutations considered by the Stanford HIV Drug Resistance Database (HIVDB v8.6) to calculate the genotypic susceptibility score (GSS, estimating the number of active drugs) for the first‐line regimen at the detection threshold windows of >20%, >5%, and >2% of the viral population. Survival analysis was conducted to evaluate the association between the GSS and risk of TF (viral load >200 copies/mL plus treatment change). Results: Baseline NGS data were available for 1380 antiretroviral therapy (ART)‐naïve participants enrolled over 2009–2013. First‐line ART included a non‐nucleoside reverse transcriptase inhibitor (NNRTI) in 976 (71%), a boosted protease inhibitor in 297 (22%), or an integrase strand transfer inhibitor in 107 (8%). The proportions of participants with GSS <3 were 7% for >20%, 10% for >5%, and 17% for the >2% thresholds, respectively. The adjusted hazard ratio of TF associated with a GSS of 0–2.75 versus 3 in the subset of participants with mutations detected at the >2% threshold was 1.66 (95% confidence interval 1.01–2.74; p = 0.05) and 2.32 (95% confidence interval 1.32–4.09; p = 0.003) after restricting the analysis to participants who started an NNRTI‐based regimen. Conclusions: Up to 17% of participants initiated ART with a GSS <3 on the basis of NGS data. Minority variants were predictive of TF, especially for participants starting NNRTI‐based regimens. [ABSTRACT FROM AUTHOR]

Published
2024
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