599 results on '"Cozzi M."'
Search Results
2. POS0533 SAFETY AND EFFICACY OF DARATUMUMAB MONOTHERAPY IN REFRACTORY LUPUS NEPHRITIS
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Roccatello, D., primary, Fenoglio, R., additional, Caniggia, I., additional, Kamgaing, J., additional, Naretto, C., additional, Cecchi, I., additional, Rubini, E., additional, Rossi, D., additional, De Simone, E., additional, Del Vecchio, G., additional, Cozzi, M., additional, and Sciascia, S., additional
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- 2024
- Full Text
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3. AB1002 IDIOPATHIC FULL-HOUSE NON-LUPUS NEPHROPATHY
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Sciascia, S., primary, Cozzi, M., additional, Barinotti, A., additional, Foddai, S. G., additional, Radin, M., additional, Cecchi, I., additional, and Roccatello, D., additional
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- 2024
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4. CSR profiles and innovation in Italian agri-food firms
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Coppola, A., Cozzi, M., Romano, S., and Viccaro, M.
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- 2022
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5. The economic value of fire damages in Tuscan agroforestry areas
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Fagarazzi C, Fratini R, Montanino M, Viccaro M, Cozzi M, Romano S, and Riccioli F
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Fire Damage ,FARSITE ,Total Economic Value ,Fire Simulation ,GIS ,Forestry ,SD1-669.5 - Abstract
The Tuscan Region (Central Italy) spends about 12 million euros every year in the prevention and suppression of forest fires. In this context, this study aims to analyse the economic and environmental benefits derived from fire suppression activities. Starting from a case study of a real fire event in Tuscany, we simulated three hypothetical scenarios (with different fire durations) without fire extinction activities planned by using the open source software FARSITE. Benefits derived from fire extinction activities can be quantified as the avoided damage, which has been calculated through the estimation of the total economic value of forests not destroyed by fire thanks to the extinction action. The avoided damage is represented by the difference between values of forest areas burned by the real fire event and those burned by simulated fire. By providing an economic estimation of avoided damages, our results confirm that forest fire services and forest management have a high impact on both the economy and the environment.
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- 2021
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6. Measurement of the atmospheric muon charge ratio with the OPERA detector
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OPERA Collaboration, Agafonova, N., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Autiero, D., Badertscher, A., Bagulya, A., Bertolin, A., Besnier, M., Bick, D., Boyarkin, V., Bozza, C., Brugière, T., Brugnera, R., Brunetti, G., Buontempo, S., Cazes, A., Chaussard, L., Chernyavsky, M., Chiarella, V., Chon-Sen, N., Chukanov, A., Cozzi, M., D'Amato, G., Corso, F. Dal, D'Ambrosio, N., De Lellis, G., D'eclais, Y., De Serio, M., Di Capua, F., Di Ferdinando, D., Di Giovanni, A., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Ebert, J., Egorov, O., Enikeev, R., Ereditato, A., Esposito, L. S., Favier, J., Felici, G., Ferber, T., Fini, R., Frekers, D., Fukuda, T., Fukushima, C., Galkin, V. I., Garfagnini, A., Giacomelli, G., Giorgini, M., Goellnitz, C., Goldberg, J., Golubkov, D., Goncharova, L., Gornushkin, Y., Grella, G., Grianti, F., Guler, M., Gustavino, C., Hagner, C., Hamada, K., Hara, T., Hierholzer, M., Hoshino, K., Ieva, M., Jakovcic, K., Jollet, C., Juget, F., Kazuyama, M., Kim, S. H., Kimura, M., Klicek, B., Knuesel, J., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Kubota, H., Lazzaro, C., Lenkeit, J., Ljubicic, A., Longhin, A., Lutter, G., Malgin, A., Mandrioli, G., Marotta, A., Marteau, J., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meisel, F., Meregaglia, A., Migliozzi, P., Mikado, S., Miyamoto, S., Monacelli, P., Morishima, K., Moser, U., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Naumov, D., Nikitina, V., Niwa, K., Nonoyama, Y., Ogawa, S., Olchevski, A., Oldorf, C., Orlova, G., Osedlo, V., Paniccia, M., Paoloni, A., Park, B. D., Park, I. G., Pastore, A., Patrizii, L., Pennacchio, E., Pessard, H., Pilipenko, V., Pistillo, C., Policastro, G., Polukhina, N., Pozzato, M., Pretzl, K., Publichenko, P., Pupilli, F., Rescigno, R., Roganova, T., Rokujo, H., Romano, G., Rosa, G., Rostovtseva, I., Rubbia, A., Russo, A., Ryasny, V., Ryazhskaya, O., Sato, O., Sato, Y., Schembri, A., Parzefall, W. Schmidt, Schroeder, H., Lavina, L. Scotto, Sheshukov, A., Shibuya, H., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Song, J. S., Spinetti, M., Stanco, L., Starkov, N., Stipcevic, M., Strauss, T., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tezuka, I., Tioukov, V., Tolun, P., Tran, T., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yakushev, V., Yoon, C. S., Yoshioka, T., Yoshida, J., Zaitsev, Y., Zemskova, S., Zghiche, A., and Zimmermann, R.
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High Energy Physics - Experiment - Abstract
The OPERA detector at the Gran Sasso underground laboratory (LNGS) was used to measure the atmospheric muon charge ratio in the TeV energy region. We analyzed 403069 atmospheric muons corresponding to 113.4 days of livetime during the 2008 CNGS run. We computed separately the muon charge ratio for single and for multiple muon events in order to select different energy regions of the primary cosmic ray spectrum and to test the charge ratio dependence on the primary composition. The measured charge ratio values were corrected taking into account the charge-misidentification errors. Data have also been grouped in five bins of the "vertical surface energy". A fit to a simplified model of muon production in the atmosphere allowed the determination of the pion and kaon charge ratios weighted by the cosmic ray energy spectrum., Comment: 14 pages, 10 figures
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- 2010
7. Time variations in the deep underground muon flux
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Cecchini, S., Cozzi, M., Dekhissi, H., Derkaoui, J., Giacomelli, G., Giorgini, M., Maaroufi, F., Mandrioli, G., Margiotta, A., Moussa, A., Patrizii, L., Sioli, M., Sirri, G., Spurio, M., and Togo, V.
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High Energy Physics - Experiment - Abstract
More than 35 million high-energy muons collected with the MACRO detector at the underground Gran Sasso Laboratory have been used to search for flux variations of different nature. Two kinds of studies were carried out: a search for the occurrence of clusters of events and a search for periodic variations. Different analysis methods, including the Scan Statistics test and the Lomb-Scargle spectral analysis have been applied to the data., Comment: 7 pages, 5 figures, accepted by EPL
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- 2009
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8. Results of the Search for Strange Quark Matter and Q-balls with the SLIM Experiment
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Cecchini, S., Cozzi, M., Di Ferdinando, D., Errico, M., Fabbri, F., Giacomelli, G., Giacomelli, R., Giorgini, M., Kumar, A., McDonald, J., Mandrioli, G., Manzoor, S., Margiotta, A., Medinaceli, E., Patrizii, L., Pinfold, J., Popa, V., Qureshi, I. E., Saavedra, O., Sahnoun, Z., Sirri, G., Spurio, M., Togo, V., Valieri, C., Velarde, A., and Zanini, A.
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High Energy Physics - Experiment - Abstract
The SLIM experiment at the Chacaltaya high altitude laboratory was sensitive to nuclearites and Q-balls, which could be present in the cosmic radiation as possible Dark Matter components. It was sensitive also to strangelets, i.e. small lumps of Strange Quark Matter predicted at such altitudes by various phenomenological models. The analysis of 427 m^2 of Nuclear Track Detectors exposed for 4.22 years showed no candidate event. New upper limits on the flux of downgoing nuclearites and Q-balls at the 90% C.L. were established. The null result also restricts models for strangelets propagation through the Earth atmosphere., Comment: 14 pages, 11 EPS figures
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- 2008
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9. The treatment and rejection of two 'strange' candidate events in the SLIM experiment
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Balestra, S., Cecchini, S., Cozzi, M., Esposti, L. Degli, Di Ferdinando, D., Errico, M., Fabbri, F., Giacomelli, G., Giorgini, M., Grandi, G., Kumar, A., McDonald, J., Mandrioli, G., Manzoor, S., Margiotta, A., Medinaceli, E., Patrizii, L., Pinfold, J., Popa, V., Qureshi, I. E., Saavedra, O., Sirri, G., Spurio, M., Togo, V., Valieri, C., Velarde, A., and Zanini, A.
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High Energy Physics - Experiment - Abstract
During the analysis of the CR39 Nuclear Track Detectors (NTDs) of the SLIM experiment exposed at the high altitude lab of Chacaltaya (Bolivia) we observed a sequence of puzzling etch-pits. We made a detailed investigation of all the CR39 and Makrofol detectors in the same stack and in all the stacks around the candidate event. We found a second puzzling sequence of etch-pits (plus some single etch-pits). The analysis of this configuration was important because we were searching for rare particles (Magnetic Monopoles, Nuclearites, Q-balls) in the cosmic radiation. Thus we analyzed in detail the evolution with increasing etching time of the etch-pits. We concluded that the two sequences of the etch-pits (and some other background etch-pits) may have originated from a rare manufacture malfunctioning which involved 1 m^2 of produced CR39., Comment: 8 pages, 5 EPS figures
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- 2008
10. Magnetic Monopole Search at high altitude with the SLIM experiment
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Balestra, S., Cecchini, S., Cozzi, M., Errico, M., Fabbri, F., Giacomelli, G., Giacomelli, R., Giorgini, M., Kumar, A., Manzoor, S., McDonald, J., Mandrioli, G., Marcellini, S., Margiotta, A., Medinaceli, E., Patrizii, L., Pinfold, J., Popa, V., Qureshi, I. E., Saavedra, O., Sahnoun, Z., Sirri, G., Spurio, M., Togo, V., Velarde, A., and Zanini, A.
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High Energy Physics - Experiment - Abstract
The SLIM experiment was a large array of nuclear track detectors located at the Chacaltaya high altitude Laboratory (5230 m a.s.l.). The detector was in particular sensitive to Intermediate Mass Magnetic Monopoles, with masses 10^5 < M <10^{12} GeV. From the analysis of the full detector exposed for more than 4 years a flux upper limit of 1.3 x 10^{-15} cm^{-2} s^{-1} sr^{-1} for downgoing fast Intermediate Mass Monopoles was established at the 90% C.L., Comment: 11 pages. 11 EPS figures. Added Fig. 5 and ref. [15]. Added more details in Sect. 2 and 3
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- 2008
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11. Track reconstruction in the emulsion-lead target of the OPERA experiment using the ESS microscope
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Arrabito, L., Bozza, C., Buontempo, S., Consiglio, L., Cozzi, M., D'Ambrosio, N., De Lellis, G., De Serio, M., Di Capua, F., Di Ferdinando, D., Di Marco, N., Ereditato, A., Esposito, L. S., Fini, R. A., Giacomelli, G., Giorgini, M., Grella, G., Ieva, M., Csathy, J. Janicsko, Juget, F., Kreslo, I., Laktineh, I., Manai, K., Mandrioli, G., Marotta, A., Migliozzi, P., Monacelli, P., Moser, U., Muciaccia, M. T., Pastore, A., Patrizii, L., Petukhov, Y., Pistillo, C., Pozzato, M., Romano, G., Rosa, G., Russo, A., Savvinov, N., Schembri, A., Lavina, L. Scotto, Simone, S., Sioli, M., Sirignano, C., Sirri, G., Strolin, P., Tioukov, V., and Waelchli, T.
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Physics - Instrumentation and Detectors - Abstract
The OPERA experiment, designed to conclusively prove the existence of $\rm \nu_\mu \to \nu_\tau$ oscillations in the atmospheric sector, makes use of a massive lead-nuclear emulsion target to observe the appearance of $\rm \nu_\tau$'s in the CNGS $\rm \nu_\mu$ beam. The location and analysis of the neutrino interactions in quasi real-time required the development of fast computer-controlled microscopes able to reconstruct particle tracks with sub-micron precision and high efficiency at a speed of 20 cm^2 / h. This paper describes the performance in particle track reconstruction of the European Scanning System, a novel automatic microscope for the measurement of emulsion films developed for OPERA., Comment: 13 pages, 10 figures
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- 2007
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12. MACRO constraints on violation of Lorentz invariance
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Cozzi, M.
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High Energy Physics - Experiment - Abstract
The energy spectrum of neutrino-induced upward-going muons in MACRO has been analysed in terms of relativity principles violating effects, keeping standard mass-induced atmospheric neutrino oscillations as the dominant source of $\nu_{\mu} \to \nu_{\tau}$ transitions. The data disfavor these exotic possibilities even at a sub-dominant level, and stringent 90% C.L. limits are placed on the Lorentz invariance violation parameter $|\Delta v| < 6 \times 10^{-24}$ at $\sin 2{\theta}_v$ = 0 and $|\Delta v| < 2.5 \div 5 \times 10^{-26}$ at $\sin 2{\theta}_v$ = $\pm$1. These limits can also be re-interpreted as upper bounds on the parameters describing violation of the Equivalence Principle., Comment: 3 pages, 2 figures. Presented at NOW 2006: Neutrino Oscillation Workshop, Conca Specchiulla, Otranto, Italy, Sep 2006. To be published in Nucl. Phys. B (Proc. Suppl.)
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- 2007
- Full Text
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13. New limits on Magnetic Monopoles searches from accelerator and non-accelerator experiments
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Cozzi, M.
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High Energy Physics - Experiment - Abstract
Here the status of the searches for ``classical Dirac'' Magnetic Monopoles (MMs) at accelerators and for GUT MMs in the cosmic radiation is discussed. We present recent analysis for ``classical Dirac'' monopoles at accelerators and the lowest flux upper limit for Magnetic Monopoles in the mass range 10$^{5}$ - 10$^{12}$ GeV obtained with the SLIM experiment at the Chacaltaya High Altitude Laboratory (5290 m a.s.l.)., Comment: 10 pages, 3 figures. Invited talk at 5th International Conference on Non-Accelerator New Physics (NANP), Dubna, Russia, June 2005
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- 2007
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14. Electron/pion separation with an Emulsion Cloud Chamber by using a Neural Network
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Arrabito, L., Autiero, D., Bozza, C., Buontempo, S., Caffari, Y., Consiglio, L., Cozzi, M., D'Ambrosio, N., De Lellis, G., De Serio, M., Di Capua, F., Di Ferdinando, D., Di Marco, N., Ereditato, A., Esposito, L. S., Gagnebin, S., Giacomelli, G., Giorgini, M., Grella, G., Hauger, M., Ieva, M., Csathy, J. Janicsko, Juget, F., Kreslo, I., Laktineh, I., Longhin, A., Mandrioli, G., Marotta, A., Marteau, J., Migliozzi, P., Monacelli, P., Moser, U., Muciaccia, M. T., Pastore, A., Patrizii, L., Pistillo, C., Pozzato, M., Romano, G., Rosa, G., Russo, A., Savvinov, N., Schembri, A., Lavina, L. Scotto, Simone, S., Sioli, M., Sirignano, C., Sirri, G., Strolin, P., and Tioukov, V.
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Physics - Data Analysis, Statistics and Probability - Abstract
We have studied the performance of a new algorithm for electron/pion separation in an Emulsion Cloud Chamber (ECC) made of lead and nuclear emulsion films. The software for separation consists of two parts: a shower reconstruction algorithm and a Neural Network that assigns to each reconstructed shower the probability to be an electron or a pion. The performance has been studied for the ECC of the OPERA experiment [1]. The $e/\pi$ separation algorithm has been optimized by using a detailed Monte Carlo simulation of the ECC and tested on real data taken at CERN (pion beams) and at DESY (electron beams). The algorithm allows to achieve a 90% electron identification efficiency with a pion misidentification smaller than 1% for energies higher than 2 GeV.
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- 2007
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15. Nuclear Track Detectors for Environmental Studies and Radiation Monitoring
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Manzoor, S., Balestra, S., Cozzi, M., Errico, M., Giacomelli, G., Giorgini, M., Kumar, A., Margiotta, A., Medinaceli, E., Patrizii, L., Popa, V., Qureshi, I. E., and Togo, V.
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Physics - Instrumentation and Detectors - Abstract
Several improvements were made for Nuclear Track Detectors (NTDs) used for environmental studies and for particle searches. A new method was used to determine the bulk etch rate of CR39 and Makrofol NTDs. It is based on the simultaneous measurement of the diameter and of the height of etch-pit cones caused by relativistic heavy ions (158 A GeV Pb(82+) and In(49+) ions) and their fragments. The use of alcohol in the etching solution improves the surface quality of NTDs and it raises their thresholds. The detectors were used for the determination of nuclear fragmentation cross sections of Iron and Silicon ions of 1.0 and 0.41 GeV/nucleon. These measurements are important for the determination of doses in hadron therapy and for doses received by astronauts. The detectors were also used in the search of massive particles in the cosmic radiation, for the determination of the mass spectrum of cosmic rays and for the evaluation of Po(210) alpha decay and of natural radon concentrations., Comment: 7 pages, 5 EPS figures. Presented at the 10th Topical Seminar on Innovative Particle and Radiation Detectors, 1-5 October 2006, Siena, Italy
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- 2006
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16. Nuclear Track Detectors for Particle Searches
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Manzoor, S., Balestra, S., Cozzi, M., Errico, M., Giacomelli, G., Giorgini, M., Kumar, A., Margiotta, A., Medinaceli, E., Patrizii, L., Popa, V., Qureshi, I. E., and Togo, V.
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Physics - Instrumentation and Detectors - Abstract
In this paper we report a search for intermediate mass magnetic monopoles and nuclearites using CR39 and Makrofol Nuclear Track Detectors (NTDs) of the SLIM large area experiment, 440 m^2 exposed at the high altitude laboratory of Chacaltaya (Bolivia) and about 100 m^2 at Koksil, Himalaya (Pakistan). We discuss the new chemical etching and improved analysis of the SLIM CR39 sheets. Preliminary limits are based on 316 $m^2$ of CR39 NTDs exposed for 3.9 y., Comment: 4 pages, 4 EPS figures. Presented at the 10th Topical Seminar on Innovative Particle and Radiation Detectors, 1-5 October 2006, Siena, Italy
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- 2006
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17. Bulk Etch Rate Measurements and Calibrations of Plastic Nuclear Track Detectors
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Balestra, S., Cozzi, M., Giacomelli, G., Giacomelli, R., Giorgini, M., Kumar, A., Mandrioli, G., Manzoor, S., Margiotta, A. R., Medinaceli, E., Patrizii, L., Popa, V., Qureshi, I. E., Rana, M. A., Sirri, G., Spurio, M., Togo, V., and Valieri, C.
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Physics - Instrumentation and Detectors - Abstract
New calibrations of CR39 and Makrofol nuclear track detectors have been obtained using 158 A GeV Pb (82+) and In (49+) ions; a new method for the bulk etch rate determination, using both cone height and base diameter measurements was developed. The CR39 charge resolution based on the etch-pit base area measurement is adequate to identify nuclear fragments in the interval 7 <= Z/beta <= 49. For CR39 the detection threshold is at REL~50 MeV cm^2/g, corresponding to a nuclear fragment with Z/beta~7. Base cone area distributions for Makrofol foils exposed to Pb (82+) ions have shown for the first time all peaks due to nuclear fragments with Z > 50; the distribution of the etched cone heights shows well separated individual peaks for Z/beta = 78 - 83 (charge pickup). The Makrofol detection threshold is at REL 2700 MeV cm^2/g, corresponding to a nuclear fragment with Z/beta~50., Comment: 11 pages, 5 EPS figures. Submitted to Nucl. Instr. Meth. B
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- 2006
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18. Hardware performance of a scanning system for high speed analysis of nuclear emulsions
- Author
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Arrabito, L., Barbuto, E., Bozza, C., Buontempo, S., Consiglio, L., Coppola, D., Cozzi, M., Damet, J., D'Ambrosio, N., De Lellis, G., De Serio, M., Di Capua, F., Di Ferdinando, D., Di Marco, N., Esposito, L. S., Giacomelli, G., Grella, G., Hauger, M., Juget, F., Kreslo, I., Giorgini, M., Ieva, M., Laktineh, I., Manai, K., Mandrioli, G., Marotta, A., Manzoor, S., Migliozzi, P., Monacelli, P., Muciaccia, M. T., Pastore, A., Patrizii, L., Pistillo, C., Pozzato, M., Royole-Degieux, P., Romano, G., Rosa, G., Savvinov, N., Schembri, A., Lavina, L. Scotto, Simone, S., Sioli, M., Sirignano, C., Sirri, G., Sorrentino, G., Strolin, P., Tioukov, V., and Waelchli, T.
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Physics - Instrumentation and Detectors - Abstract
The use of nuclear emulsions in very large physics experiments is now possible thanks to the recent improvements in the industrial production of emulsions and to the development of fast automated microscopes. In this paper the hardware performances of the European Scanning System (ESS) are described. The ESS is a very fast automatic system developed for the mass scanning of the emulsions of the OPERA experiment, which requires microscopes with scanning speeds of about 20 cm^2/h in an emulsion volume of 44 micron thickness., Comment: 16 pages, 12 figures, Accepted by Nucl. Instrum. Meth. A
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- 2006
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19. Time variations in the deep underground muon flux measured by MACRO
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Becherini, Y., Cecchini, S., Cozzi, M., Dekhissi, H., Derkaoui, J., Giacomelli, G., Giorgini, M., Maaroufi, F., Mandrioli, G., Margiotta, A., Manzoor, S., Moussa, A., Patrizii, L., Popa, V., Sioli, M., Sirri, G., Spurio, M., and Togo, V.
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Astrophysics - Abstract
More than 30 million of high-energy muons collected with the MACRO detector at the underground Gran Sasso Laboratory have been used to search for flux variations of different natures. Two kinds of studies were carried out: search for periodic variations and for the occurrence of clusters of events. Different analysis methods, including Lomb-Scargle spectral analysis and Scan Test statistics have been applied to the data., Comment: 6 pages, 4 EPS figures. Talk given at the 29th ICRC, Pune, India, 3-10 August 2005
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- 2005
20. Search for exotic contributions to atmospheric neutrino oscillations
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Battistoni, G., Becherini, Y., Cecchini, S., Cozzi, M., Dekhissi, H., Esposito, L., Giacomelli, G., Giorgini, M., Mandrioli, G., Manzoor, S., Margiotta, A., Patrizii, L., Popa, V., Sioli, M., Sirri, G., Spurio, M., and Togo, V.
- Subjects
High Energy Physics - Experiment - Abstract
The energy spectrum of neutrino-induced upward-going muons in MACRO was analysed in terms of relativity principles violating effects, keeping standard mass-induced atmospheric neutrino oscillations as the dominant effect. The data disfavor these possibilities even at a sub-dominant level; stringent 90% C.L. limits are placed on the Lorentz invariance violation parameter $|\Delta v| < 6 \times 10^{-24}$ at $\sin 2{\theta}_v$ = 0 and $|\Delta v| < 2.5 \div 5 \times 10^{-26}$ at $\sin 2{\theta}_v$ = $\pm$1. The limits can be re-interpreted as bounds on the Equivalence Principle violation parameters., Comment: Presented at the 29th I.C.R.C., Pune, India (2005)
- Published
- 2005
- Full Text
- View/download PDF
21. Search for spontaneous muon emission from lead nuclei
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Arrabito, L., Autiero, D., Barbuto, E., Bozza, C., Cecchini, S., Consiglio, L., Cozzi, M., D'Ambrosio, N., Declais, Y., De Lellis, G., De Rosa, G., De Serio, M., Di Ferdinando, D., Di Giovanni, A., Di Marco, N., Esposito, L. S., Giacomelli, G., Giorgini, M., Grella, G., Hauger, M., Ieva, M., Ion, D. B., Janicsko, I., Juget, F., Laktineh, I., Mandrioli, G., Manzoor, S., Margiotta, A., Migliozzi, P., Monacelli, P., Muciaccia, M. T., Patrizii, L., Pistillo, C., Popa, V., Romano, G., Rosa, G., Royole-Degieux, P., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Sorrentino, G., Spurio, M., and Tioukov, V.
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High Energy Physics - Experiment - Abstract
We describe a possible search for muonic radioactivity from lead nuclei using the base elements ("bricks" composed by lead and nuclear emulsion sheets) of the long-baseline OPERA neutrino experiment. We present the results of a Monte Carlo simulation concerning the expected event topologies and estimates of the background events. Using few bricks, we could reach a good sensitivity level., Comment: 12 pages, 4 figures
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- 2005
22. Search for a Lorentz invariance violation contribution in atmospheric neutrino oscillations using MACRO data
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Battistoni, G., Becherini, Y., Cecchini, S., Cozzi, M., Dekhissi, H., Esposito, L. S., Giacomelli, G., Giorgini, M., Mandrioli, G., Manzoor, S., Margiotta, A., Patrizii, L., Popa, V., Sioli, M., Sirri, G., Spurio, M., and Togo, V.
- Subjects
High Energy Physics - Experiment - Abstract
Neutrino-induced upward-going muons in MACRO have been analysed in terms of relativity principles violating effects, keeping standard mass-induced atmospheric neutrino oscillations as the dominant source of nu_mu -> nu_tau transitions. The data disfavor these exotic possibilities even at a sub-dominant level, and stringent 90% C.L. limits are placed on the Lorentz invariance violation parameter |Delta v| < 6 * 10^(-24) at sin2theta_v = 0 and |Delta v| < 2.5--5 * 10^(-26) at sin2theta_v = +/-1. These limits can also be re-interpreted as upper bounds on the parameters describing violation of the Equivalence Principle., Comment: 8 pages, 2 figures, submitted to Physics Letters B
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- 2005
- Full Text
- View/download PDF
23. Search for Intermediate Mass Magnetic Monopoles and Nuclearites with the SLIM experiment
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Cecchini, S., Chiarusi, T., Di Ferdinando, D., Cozzi, M., Frutti, M., Giacomelli, G., Kumar, A., Manzoor, S., McDonald, J., Medinaceli, E., Nogales, J., Patrizii, L., Pinfold, J., Popa, V., Qureshi, I. E., Saavedra, O., Sher, G., Shahzad, M. I., Spurio, M., Ticona, R., Togo, V., and Velarde, A.
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High Energy Physics - Experiment - Abstract
SLIM is a large area experiment (440 m2) installed at the Chacaltaya cosmic ray laboratory since 2001, and about 100 m2 at Koksil, Himalaya, since 2003. It is devoted to the search for intermediate mass magnetic monopoles (107-1013 GeV/c2) and nuclearites in the cosmic radiation using stacks of CR39 and Makrofol nuclear track detectors. In four years of operation it will reach a sensitivity to a flux of about 10-15 cm-2 s-1 sr-1. We present the results of the calibration of CR39 and Makrofol and the analysis of a first sample of the exposed detector., Comment: Presented at the 22nd ICNTS, Barcelona 2004
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- 2005
24. Calibration of the Makrofol Nuclear Track Detector using Relativistic Lead Ions
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Cecchini, S., Chiarusi, T., Cozzi, M., Di Ferdinando, D., Frutti, M., Giacomelli, G., Kumar, A., Mandrioli, G., Manzoor, S., Medinaceli, E., Patrizii, L., Popa, V., Quereshi, I. E., Spurio, M., and Togo, V.
- Subjects
High Energy Physics - Experiment - Abstract
We present the calibration of the Makrofol nuclear detector using Pb ions of 158 AGeV., Comment: 6 pages, 4 figures. Presented at the 22^nd ICNTS, Barcelona, Spain, 2004
- Published
- 2005
25. Time correlations of high energy muons in an underground detector
- Author
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Becherini, Y., Cecchini, S., Chiarusi, T., Cozzi, M., Dekhissi, H., Derkaoui, J., Esposito, L. S., Giacomelli, G., Giorgini, M., Giglietto, N., Maaroufi, F., Mandrioli, G., Margiotta, A., Manzoor, S., Moussa, A., Patrizii, L., Popa, V., Sioli, M., Sirri, G., Spurio, M., and Togo, V.
- Subjects
Astrophysics - Abstract
We present the result of a search for correlations in the arrival times of high energy muons collected from 1995 till 2000 with the streamer tube system of the complete MACRO detector at the underground Gran Sasso Lab. Large samples of single muons (8.6 million), double muons (0.46 million) and multiple muons with multiplicities from 3 to 6 (0.08 million) were selected. These samples were used to search for time correlations of cosmic ray particles coming from the whole upper hemisphere or from selected space cones. The results of our analyses confirm with high statistics a random arrival time distribution of high energy cosmic rays., Comment: (12 pages, 7 figures, Accepted for publication in Astroparticle Physics)
- Published
- 2005
- Full Text
- View/download PDF
26. Effects of pre-analytical variables on flow cytometric diagnosis of canine lymphoma: A retrospective study (2009–2015)
- Author
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Comazzi, S., Cozzi, M., Bernardi, S., Zanella, D.R., Aresu, L., Stefanello, D., Marconato, L., and Martini, V.
- Published
- 2018
- Full Text
- View/download PDF
27. Loss of CD45 cell surface expression in canine T-zone lymphoma results from reduced gene expression
- Author
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Martini, V., Cozzi, M., Aricò, A., Dalla Rovere, G., Poggi, A., Albonico, F., Mortarino, M., Ciusani, E., Aresu, L., and Comazzi, S.
- Published
- 2017
- Full Text
- View/download PDF
28. Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report
- Author
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Garzone, Davide, Terheyden, Jan Henrik, Morelle, Olivier, Wintergerst, Maximilian W.M., Saßmannshausen, Marlene, Schmitz-Valckenberg, Steffen, Pfau, Maximilian, Thiele, Sarah, Poor, Stephen, Leal, Sergio, Holz, Frank G., Finger, Robert P., Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M., Binns, A., Boon, C. J.F., Böttger, M., Bouchet, C., Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Fletcher, E., Francisco, C., Gutfleisch, M., Hogg, R., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Lechanteur, Y. T.E., Luhmann, U. F.O., Lüning, A., Schmid, M., Ophthalmology, Amsterdam Neuroscience - Complex Trait Genetics, Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M., Binns, A., Boon, C. J. F., Böttger, M., Bouchet, C., Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Fletcher, E., Francisco, C., Gutfleisch, M., Hogg, R., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Lechanteur, Y. T. E., Luhmann, U. F. O., Lüning, A., Marques, I., Martinho, C., Montesano, G., Mulyukov, Z., Paques, M., Parodi, B., Parravano, M., Penas, S., Peters, T., Peto, T., Priglinger, S., Rowen, D., Rubin, G. S., Sahel, J., Sánchez, C., Sander, O., Schmid, M., Schrinner-Fenske, H., Siedlecki, J., Silva, R., Skelly, A., Souied, E., Staurenghi, G., Stöhr, L., Taylor, D. J., Tufail, A., Varano, M., Vieweg, L., Wintergerst, L., Wolf, A., and Zakaria, N.
- Subjects
diagnosis [Macular Degeneration] ,methods [Tomography, Optical Coherence] ,Fovea Centralis ,Multidisciplinary ,Humans ,ddc:600 ,Retina ,Software - Abstract
Drusen are hallmarks of early and intermediate age-related macular degeneration (AMD) but their quantification remains a challenge. We compared automated drusen volume measurements between different OCT devices. We included 380 eyes from 200 individuals with bilateral intermediate (iAMD, n = 126), early (eAMD, n = 25) or no AMD (n = 49) from the MACUSTAR study. We assessed OCT scans from Cirrus (200 × 200 macular cube, 6 × 6 mm; Zeiss Meditec, CA) and Spectralis (20° × 20°, 25 B-scans; 30° × 25°, 241 B-scans; Heidelberg Engineering, Germany) devices. Sensitivity and specificity for drusen detection and differences between modalities were assessed with intra-class correlation coefficients (ICCs) and mean difference in a 5 mm diameter fovea-centered circle. Specificity was > 90% in the three modalities. In eAMD, we observed highest sensitivity in the denser Spectralis scan (68.1). The two different Spectralis modalities showed a significantly higher agreement in quantifying drusen volume in iAMD (ICC 0.993 [0.991–0.994]) than the dense Spectralis with Cirrus scan (ICC 0.807 [0.757–0.847]). Formulae for drusen volume conversion in iAMD between the two devices are provided. Automated drusen volume measures are not interchangeable between devices and softwares and need to be interpreted with the used imaging devices and software in mind. Accounting for systematic difference between methods increases comparability and conversion formulae are provided. Less dense scans did not affect drusen volume measurements in iAMD but decreased sensitivity for medium drusen in eAMD.Trial registration: ClinicalTrials.gov NCT03349801. Registered on 22 November 2017.
- Published
- 2022
29. Predicting Petrophysical Properties and Sedimentary Structures From Core Images
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Cozzi, M., primary, Luciani, A., additional, Maletti, G., additional, Carniani, D., additional, Wen, R., additional, Shu, Y., additional, and Luo, X., additional
- Published
- 2023
- Full Text
- View/download PDF
30. Constraining Digital Core Modelling with Grain Size Data: Methodology and Tool
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Cozzi, M., primary, Luciani, A., additional, Maletti, G., additional, Wen, R., additional, Shu, Y., additional, and Luo, X., additional
- Published
- 2023
- Full Text
- View/download PDF
31. Characteristics and Spatial Distribution of Structural Features in Age-Related Macular Degeneration
- Author
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Saßmannshausen, Marlene, primary, Behning, Charlotte, additional, Weinz, Jonas, additional, Goerdt, Lukas, additional, Terheyden, Jan H., additional, Chang, Petrus, additional, Schmid, Matthias, additional, Poor, Stephen H., additional, Zakaria, Nadia, additional, Finger, Robert P., additional, Holz, Frank G., additional, Pfau, Maximilian, additional, Schmitz-Valckenberg, Steffen, additional, Thiele, Sarah, additional, Agostini, H., additional, Altay, L., additional, Atia, R., additional, Bandello, F., additional, Basile, P.G., additional, Behning, C., additional, Belmouhand, M., additional, Berger, M., additional, Binns, A., additional, Boon, C.J.F., additional, Böttger, M., additional, Bouchet, C., additional, Brazier, J.E., additional, Butt, T., additional, Carapezzi, C., additional, Carlton, J., additional, Carneiro, A., additional, Charil, A., additional, Coimbra, R., additional, Cozzi, M., additional, Crabb, D.P., additional, Cunha-Vaz, J., additional, Dahlke, C., additional, de Sisternes, L., additional, Dunbar, H., additional, Finger, R.P., additional, Fletcher, E., additional, Floyd, H., additional, Francisco, C., additional, Gutfleisch, M., additional, Hogg, R., additional, Holz, F.G., additional, Hoyng, C.B., additional, Kilani, A., additional, Krätzschmar, J., additional, Kühlewein, L., additional, Larsen, M., additional, Leal, S., additional, Lechanteur, Y.T.E., additional, Luhmann, U.F.O., additional, Lüning, A., additional, Marques, I., additional, Martinho, C., additional, Montesano, G., additional, Mulyukov, Z., additional, Paques, M., additional, Parodi, B., additional, Parravano, M., additional, Penas, S., additional, Peters, T., additional, Peto, T., additional, Pfau, M., additional, Poor, S., additional, Priglinger, S., additional, Rowen, D., additional, Rubin, G.S., additional, Sahel, J., additional, Sánchez, C., additional, Sander, O., additional, Saßmannshausen, M., additional, Schmid, M., additional, Schmitz-Valckenberg, S., additional, Schrinner-Fenske, H., additional, Siedlecki, J., additional, Silva, R., additional, Skelly, A., additional, Souied, E., additional, Staurenghi, G., additional, Stöhr, L., additional, Taylor, D.J., additional, Terheyden, J.H., additional, Thiele, S., additional, Tufail, A., additional, Varano, M., additional, Vieweg, L., additional, Wintergerst, L., additional, Wolf, A., additional, and Zakaria, N., additional
- Published
- 2022
- Full Text
- View/download PDF
32. HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies
- Author
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Tedesco, B., Vendredy, L., Adriaenssens, E., Cozzi, M., Asselbergh, B., Crippa, V., Cristofani, R., Rusmini, P., Ferrari, V., Casarotto, E., Chierichetti, M., Mina, F., Pramaggiore, P., Galbiati, M., Piccolella, M., Baets, J., Baeke, F., De Rycke, R., Mouly, V., Laurenzi, T., Eberini, I., Vihola, A., Udd, B., Weiss, L., Kimonis, V., Timmerman, V., Poletti, A., Tampere University, Clinical Medicine, and Tays Research Services
- Subjects
318 Medical biotechnology ,BAG3 ,CASA ,neuromuscular disorders ,HSPA ,HSPB8 ,misfolding ,myopathy ,neuropathy ,protein quality control ,Settore BIO/09 - Fisiologia ,Settore BIO/13 - Biologia Applicata ,Settore BIO/10 - Biochimica ,Human medicine ,Biology - Abstract
Chaperone-assisted selective autophagy (CASA) is a highly selective pathway for the disposal of misfolding and aggregating proteins. In muscle, CASA assures muscle integrity by favoring the turnover of structural components damaged by mechanical strain. In neurons, CASA promotes the removal of aggregating substrates. A crucial player of CASA is HSPB8 (heat shock protein family B (small) member 8), which acts in a complex with HSPA, their cochaperone BAG3, and the E3 ubiquitin ligase STUB1. Recently, four novel HSPB8 frameshift (fs) gene mutations have been linked to neuromyopathies, and encode carboxy-terminally mutated HSPB8, sharing a common C-terminal extension. Here, we analyzed the biochemical and functional alterations associated with the HSPB8_fs mutant proteins. We demonstrated that HSPB8_fs mutants are highly insoluble and tend to form proteinaceous aggregates in the cytoplasm. Notably, all HSPB8 frameshift mutants retain their ability to interact with CASA members but sequester them into the HSPB8-positive aggregates together with two autophagy receptors SQSTM1/p62 and TAX1BP1. This copartitioning process negatively affects the CASA capability to remove its clients and causes a general failure in proteostasis response. Further analyses revealed that the aggregation of the HSPB8_fs mutants occurs independently of the other CASA members or from the autophagy receptors interaction, but it is an intrinsic feature of the mutated amino acid sequence. HSPB8_fs mutants aggregation alters the differentiation capacity of muscle cells and impairs sarcomere organization. Collectively, these results shed light on a potential pathogenic mechanism shared by the HSPB8_fs mutants described in neuromuscular diseases. Abbreviations : ACD: α-crystallin domain; ACTN: actinin alpha; BAG3: BAG cochaperone 3; C: carboxy; CASA: chaperone-assisted selective autophagy; CE: carboxy-terminal extension; CLEM: correlative light and electron microscopy; CMT2L: Charcot-Marie-Tooth type 2L; CTR: carboxy-terminal region; dHMNII: distal hereditary motor neuropathy type II; EV: empty vector; FRA: filter retardation assay; fs: frameshift; HSPA/HSP70: heat shock protein family A (Hsp70); HSPB1/Hsp27: heat shock protein family B (small) member 1; HSPB8/Hsp22: heat shock protein family B (small) member 8; HTT: huntingtin; KO: knockout; MAP1LC3B/LC3: microtubule associated protein 1 light chain 3 beta; MD: molecular dynamics; MTOC: microtubule organizing center; MYH: myosin heavy chain; MYOG: myogenin; NBR1: NBR1 autophagy cargo receptor; CALCOCO2/NDP52: calcium binding and coiled-coil domain 2; NSC34: Neuroblastoma X Spinal Cord 34; OPTN: optineurin; polyQ: polyglutamine; SQSTM1/p62: sequestosome 1; STUB1/CHIP: STIP1 homology and U-box containing protein 1; TARDBP/TDP-43: TAR DNA binding protein; TAX1BP1: Tax1 binding protein 1; TUBA: tubulin alpha; WT: wild-type. publishedVersion
- Published
- 2023
33. One gene, many phenotypes: investigating KIF5A-linked neurodegeneration mechanisms
- Author
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Cozzi, M., Barbara, T., Cristofani, R.M., Ferrari, V., Casarotto, E., Chierichetti, M., Pramaggiore, P., Piccolella, M., Galbiati, M., Rusmini, P., Crippa, V., Cinzia, G., Stefania, M., Santangelo, S., Ratti, A., Franco, T., and Poletti, A.
- Subjects
Settore BIO/13 - Biologia Applicata - Published
- 2022
34. Looking at genetic structure and selection signatures of the Mexican chicken population using single nucleotide polymorphism markers
- Author
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Strillacci, M G, Vega-Murillo, V E, Román-Ponce, S I, López, Ruiz F J, Cozzi, M C, Gorla, E, Cerolini, S, Bertolini, F, Fontanesi, L, and Bagnato, A
- Published
- 2018
- Full Text
- View/download PDF
35. How PQC inhibition modulates miRNA loading in large and small extracellular vesicles
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Casarotto, E., Garofalo, M., Messa, L., Sproviero, D., Carelli, S., Cozzi, M., Chierichetti, M., Cristofani, R., Ferrari, V., Galbiati, M., Mina, F., Piccolella, M., Rusmini, P., Tedesco, B., Pramaggiore, P., Cereda, C., Gagliardi, S., Poletti, A., and Crippa, V.
- Subjects
Settore BIO/13 - Biologia Applicata - Published
- 2022
36. Extracellular vesicles cooperate with PQC system for the clearance of TDP-43 species associated with ALS and FTD
- Author
-
Casarotto, E., Sproviero, D., Corridori, E., Gagliani, M.C., Cozzi, M., Chierichetti, M., Cristofani, R., Ferrari, V., Galbiati, M., Mina, F., Piccolella, M., Rusmini, P., Tedesco, B., Gagliardi, S., Cortese, K., Cereda, C., Poletti, A., and Crippa, V.
- Subjects
Settore BIO/13 - Biologia Applicata - Published
- 2022
37. Nuclear Track Detectors. Searches for Magnetic Monopoles and for Nuclearites
- Author
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Cozzi, M., Patrizii, L., Giacomelli, Giorgio, editor, Spurio, Maurizio, editor, and Derkaoui, Jamal Eddine, editor
- Published
- 2001
- Full Text
- View/download PDF
38. Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration:a MACUSTAR study report
- Author
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Saßmannshausen, Marlene, Behning, Charlotte, Isselmann, Ben, Schmid, Matthias, Finger, Robert P., Holz, F. G., Schmitz-Valckenberg, Steffen, Pfau, Maximilian, Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M., Binns, A., Boon, C. J.F., Böttger, M., Bouchet, C., Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Finger, R. P., Fletcher, E., Floyd, H., Francisco, C., Gutfleisch, M., Hogg, R., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Leal, S., Lechanteur, Y. T.E., Luhmann, U. F.O., Lüning, A., Marques, I., Saßmannshausen, Marlene, Behning, Charlotte, Isselmann, Ben, Schmid, Matthias, Finger, Robert P., Holz, F. G., Schmitz-Valckenberg, Steffen, Pfau, Maximilian, Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M., Binns, A., Boon, C. J.F., Böttger, M., Bouchet, C., Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Finger, R. P., Fletcher, E., Floyd, H., Francisco, C., Gutfleisch, M., Hogg, R., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Leal, S., Lechanteur, Y. T.E., Luhmann, U. F.O., Lüning, A., and Marques, I.
- Abstract
Quantification of the relative ellipsoid zone reflectivity (rEZR) might be a structural surrogate parameter for an early disease progression in the context of age-related macular degeneration (AMD). Within the European multicenter, cross-sectional MACUSTAR study, we have devised an automatic approach to determine the mean rEZR [arbitrary units, AU] at two independent visits in SD-OCT volume scans in study participants. Linear mixed-effects models were applied to analyze the association of AMD stage and AMD associated high-risk features including presence of pigmentary abnormalities, reticular pseudodrusen (RPD), volume of the retinal-pigment-epithelial–drusenoid-complex (RPEDC) with the rEZR. Intra-class correlation coefficients (ICC) were determined for rEZR reliability analysis. Within the overall study cohort (301 participants), we could observe decreased rEZR values (coefficient estimate ± standard error) of − 8.05 ± 2.44 AU (p = 0.0011) in the intermediate and of − 22.35 ± 3.28 AU (p < 0.0001) in the late AMD group. RPD presence was significantly associated with the rEZR in iAMD eyes (− 6.49 ± 3.14 AU; p = 0.0403), while there was a good ICC of 0.846 (95% confidence interval: 0.809; 0.876) in the overall study cohort. This study showed an association of rEZR with increasing disease severity and the presence of iAMD high-risk features. Further studies are necessary to evaluate the rEZR’s value as a novel biomarker for AMD and disease progression.
- Published
- 2022
39. Comparability of automated drusen volume measurements in age-related macular degeneration:a MACUSTAR study report
- Author
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Garzone, Davide, Terheyden, Jan Henrik, Morelle, Olivier, Wintergerst, Maximilian W.M., Saßmannshausen, Marlene, Schmitz-Valckenberg, Steffen, Pfau, Maximilian, Thiele, Sarah, Poor, Stephen, Leal, Sergio, Holz, Frank G., Finger, Robert P., Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M., Binns, A., Boon, C. J.F., Böttger, M., Bouchet, C., Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Fletcher, E., Francisco, C., Gutfleisch, M., Hogg, R., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Lechanteur, Y. T.E., Luhmann, U. F.O., Lüning, A., Schmid, M., Garzone, Davide, Terheyden, Jan Henrik, Morelle, Olivier, Wintergerst, Maximilian W.M., Saßmannshausen, Marlene, Schmitz-Valckenberg, Steffen, Pfau, Maximilian, Thiele, Sarah, Poor, Stephen, Leal, Sergio, Holz, Frank G., Finger, Robert P., Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M., Binns, A., Boon, C. J.F., Böttger, M., Bouchet, C., Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Fletcher, E., Francisco, C., Gutfleisch, M., Hogg, R., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Lechanteur, Y. T.E., Luhmann, U. F.O., Lüning, A., and Schmid, M.
- Abstract
Drusen are hallmarks of early and intermediate age-related macular degeneration (AMD) but their quantification remains a challenge. We compared automated drusen volume measurements between different OCT devices. We included 380 eyes from 200 individuals with bilateral intermediate (iAMD, n = 126), early (eAMD, n = 25) or no AMD (n = 49) from the MACUSTAR study. We assessed OCT scans from Cirrus (200 × 200 macular cube, 6 × 6 mm; Zeiss Meditec, CA) and Spectralis (20° × 20°, 25 B-scans; 30° × 25°, 241 B-scans; Heidelberg Engineering, Germany) devices. Sensitivity and specificity for drusen detection and differences between modalities were assessed with intra-class correlation coefficients (ICCs) and mean difference in a 5 mm diameter fovea-centered circle. Specificity was > 90% in the three modalities. In eAMD, we observed highest sensitivity in the denser Spectralis scan (68.1). The two different Spectralis modalities showed a significantly higher agreement in quantifying drusen volume in iAMD (ICC 0.993 [0.991–0.994]) than the dense Spectralis with Cirrus scan (ICC 0.807 [0.757–0.847]). Formulae for drusen volume conversion in iAMD between the two devices are provided. Automated drusen volume measures are not interchangeable between devices and softwares and need to be interpreted with the used imaging devices and software in mind. Accounting for systematic difference between methods increases comparability and conversion formulae are provided. Less dense scans did not affect drusen volume measurements in iAMD but decreased sensitivity for medium drusen in eAMD. Trial registration: ClinicalTrials.gov NCT03349801. Registered on 22 November 2017.
- Published
- 2022
40. The Effect of Filters on CPAP Delivery by Helmet
- Author
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Privitera, D, Capsoni, N, Zadek, F, Vailati, P, Airoldi, C, Cozzi, M, Pierotti, F, Fumagalli, R, Bellone, A, Langer, T, Privitera, Daniele, Capsoni, Nicolò, Zadek, Francesco, Vailati, Paolo, Airoldi, Chiara, Cozzi, Mattia, Pierotti, Federico, Fumagalli, Roberto, Bellone, Andrea, Langer, Thomas, Privitera, D, Capsoni, N, Zadek, F, Vailati, P, Airoldi, C, Cozzi, M, Pierotti, F, Fumagalli, R, Bellone, A, Langer, T, Privitera, Daniele, Capsoni, Nicolò, Zadek, Francesco, Vailati, Paolo, Airoldi, Chiara, Cozzi, Mattia, Pierotti, Federico, Fumagalli, Roberto, Bellone, Andrea, and Langer, Thomas
- Abstract
BACKGROUND: When helmet CPAP is performed using a Venturi system, filters are frequently interposed in the respiratory circuit to reduce noise within the helmet. The effect of the interposition of these filters on delivered fresh gas flow and the resulting FIO2 is currently unknown. METHODS: In a bench study, 2 different Venturi systems (WhisperFlow and Harol) were used to generate 3 different gas flow/FIO2 combinations (80 L/min-FIO2 0.6, 100 L/min-FIO2 0.5, 120 L/min-FIO2 0.4). Different combinations of filters were applied at the flow generator input line and/or at the helmet inlet port. Two types of filters were used for this purpose: a heat and moisture exchanger filter and an electrostatic filter. The setup without filters was used as baseline. Gas flow and FIO2 were measured for each setup. RESULTS: Compared to baseline, the interposition of filters reduced the gas flow between 1–13% (P < .001). The application of a filter at the Venturi system or at the helmet generated a comparable flow reduction (-3 ± 2% vs-4 ± 2%, P = .12), whereas a greater flow reduction (-7 ± 4%) was observed when filters were applied at both sites (P < .001). An increase in FIO2 up to 5% was observed with filters applied. A strong inverse linear relationship (P < .001) was observed between the resulting gas flow and FIO2. CONCLUSIONS: The use of filters during helmet CPAP reduced the flow delivered to the helmet and, consequently, modified FIO2. If filters are applied, an adequate gas flow should be administered to guarantee a constant CPAP during the entire respiratory cycle and avoid rebreathing. Moreover, it might be important to measure the effective FIO2 delivered to the patient to guarantee a precise assessment of oxygenation.
- Published
- 2022
41. Identification of HSPB8 modulators counteracting misfolded protein accumulation in neurodegenerative diseases
- Author
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Chierichetti, M., Cerretani, M., Ciammaichella, A., Crippa, V., Rusmini, P., Ferrari, V., Tedesco, B., Casarotto, E., Cozzi, M., Mina, F., Pramaggiore, P., Galbiati, M., Piccolella, M., Bresciani, A., Cristofani, R., and Poletti, A.
- Subjects
proteasome ,Settore BIO/13 - Biologia Applicata ,neurodegenerative disorders ,cancer ,HSPB8 ,neuromuscular disorders ,chaperone-assisted selective autophagy ,Settore BIO/09 - Fisiologia - Published
- 2022
42. Insights on Human Small Heat Shock Proteins and Their Alterations in Diseases
- Author
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Tedesco, B., primary, Cristofani, R., additional, Ferrari, V., additional, Cozzi, M., additional, Rusmini, P., additional, Casarotto, E., additional, Chierichetti, M., additional, Mina, F., additional, Galbiati, M., additional, Piccolella, M., additional, Crippa, V., additional, and Poletti, A., additional
- Published
- 2022
- Full Text
- View/download PDF
43. The role of extracellular vesicles in TDP-43 proteinopathies
- Author
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Casarotto, E., Sproviero, D., Corridori, E., Gagliani, M.C., Tedesco, B., Cristofani, R., Ferrari, V., Chierichetti, M., Cozzi, M., Mina, F., Rusmini, P., Galbiati, M., Gagliardi, S., Cortese, K., Cereda, C., Poletti, A., and Crippa, V.
- Subjects
Settore BIO/13 - Biologia Applicata - Published
- 2021
44. A new framework for supply chain management : Conceptual model and empirical test
- Author
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Cigolini, R., Cozzi, M., and Perona, M.
- Published
- 2004
- Full Text
- View/download PDF
45. Bird density, stress markers and growth performance in the Italian chicken breed Milanino
- Author
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Mosca, F., Madeddu, M., Mangiagalli, M. G., Colombo, E., Cozzi, M. C., Zaniboni, L., and Cerolini, S.
- Published
- 2015
- Full Text
- View/download PDF
46. Neo-adjuvant exemestane in elderly patients with breast cancer: a phase II, multicentre, open-label, Italian study
- Author
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Mustacchi, G., Mansutti, M., Sacco, C., Barni, S., Farris, A., Cazzaniga, M., Cozzi, M., and Dellach, C.
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- 2009
- Full Text
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47. Towards sustainable and inclusive communities: an integrated approach to assess sustainability in rural areas
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Cozzi, M., Prete, C., Viccaro, M., Riccioli, F., Fagarazzi, C., and Romano, S.
- Subjects
Mazziotta and Pareto index ,New sustainability dimensions ,Rural development ,Spatial Decision Support System ,Industries. Land use. Labor ,HD28-9999 - Abstract
Sustainable development is a priority in EU rural development strategies. Due to the multidimensionality of the sustainability issue, this paper presents a Spatial Decision Support System to assess territorial sustainability and help decision-makers in rural planning process. Four globally valid sustainability dimensions were considered (long-term ecological sustainability, satisfaction of basic human needs, promotion of intragenerational and intergenerational equity), measured by a set of socio-cultural-political-environmental indicators by using the Mazziotta and Pareto method. The results of the S-DSS, implemented and verified in Basilicata region (southern Italy), provide the maps of sustainability values for each dimension at municipalities level, showing the usefulness of the tool to identify and monitor rural areas that require priority interventions and resources, in order to foster sustainable rural development., Aestimum, 2020: Special Issue "Sustainable development and circular economy"
- Published
- 2021
48. Measurement of the atmospheric muon charge ratio with the OPERA detector
- Author
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Agafonova, N., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Autiero, D., Badertscher, A., Bagulya, A., Bertolin, A., Besnier, M., Bick, D., Boyarkin, V., Bozza, C., Brugière, T., Brugnera, R., Brunetti, G., Buontempo, S., Cazes, A., Chaussard, L., Chernyavsky, M., Chiarella, V., Chon-Sen, N., Chukanov, A., Cozzi, M., D’Amato, G., Dal Corso, F., D’Ambrosio, N., De Lellis, G., Déclais, Y., De Serio, M., Di Capua, F., Di Ferdinando, D., Di Giovanni, A., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Ebert, J., Egorov, O., Enikeev, R., Ereditato, A., Esposito, L. S., Favier, J., Felici, G., Ferber, T., Fini, R., Frekers, D., Fukuda, T., Fukushima, C., Galkin, V. I., Garfagnini, A., Giacomelli, G., Giorgini, M., Goellnitz, C., Goldberg, J., Golubkov, D., Goncharova, L., Gornushkin, Y., Grella, G., Grianti, F., Guler, M., Gustavino, C., Hagner, C., Hamada, K., Hara, T., Hierholzer, M., Hoshino, K., Ieva, M., Jakovcic, K., Jollet, C., Juget, F., Kazuyama, M., Kim, S. H., Kimura, M., Klicek, B., Knuesel, J., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Kubota, H., Lazzaro, C., Lenkeit, J., Ljubicic, A., Longhin, A., Lutter, G., Malgin, A., Mandrioli, G., Marotta, A., Marteau, J., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meisel, F., Meregaglia, A., Migliozzi, P., Mikado, S., Miyamoto, S., Monacelli, P., Morishima, K., Moser, U., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Naumov, D., Nikitina, V., Niwa, K., Nonoyama, Y., Ogawa, S., Olchevski, A., Oldorf, C., Orlova, G., Osedlo, V., Paniccia, M., Paoloni, A., Park, B. D., Park, I. G., Pastore, A., Patrizii, L., Pennacchio, E., Pessard, H., Pilipenko, V., Pistillo, C., Policastro, G., Polukhina, N., Pozzato, M., Pretzl, K., Publichenko, P., Pupilli, F., Rescigno, R., Roganova, T., Rokujo, H., Romano, G., Rosa, G., Rostovtseva, I., Rubbia, A., Russo, A., Ryasny, V., Ryazhskaya, O., Sato, O., Sato, Y., Schembri, A., Schmidt Parzefall, W., Schroeder, H., Scotto Lavina, L., Sheshukov, A., Shibuya, H., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Song, J. S., Spinetti, M., Stanco, L., Starkov, N., Stipcevic, M., Strauss, T., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tezuka, I., Tioukov, V., Tolun, P., Tran, T., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yakushev, V., Yoon, C. S., Yoshioka, T., Yoshida, J., Zaitsev, Y., Zemskova, S., Zghiche, A., and Zimmermann, R.
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- 2010
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49. Quantitative trait loci mapping for conjugated linoleic acid, vaccenic acid and δ9-desaturase in Italian Brown Swiss dairy cattle using selective DNA pooling
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Strillacci, M. G., Frigo, E., Canavesi, F., Ungar, Y., Schiavini, F., Zaniboni, L., Reghenzani, L., Cozzi, M. C., Samoré, A. B., Kashi, Y., Shimoni, E., Tal-Stein, R., Soller, M., Lipkin, E., and Bagnato, A.
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- 2014
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50. POS1393 QUANTITATIVE AUTOFLUORESCENCE FINDINGS IN PATIENTS UNDERGOING HYDROXYCHLOROQUINE TREATMENT
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Parrulli, S., primary, Cozzi, M., additional, Airaldi, M., additional, Romano, F., additional, Viola, F., additional, Sarzi-Puttini, P., additional, Staurenghi, G., additional, and Invernizzi, A., additional
- Published
- 2021
- Full Text
- View/download PDF
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