37 results on '"Coyle, Joseph E."'
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2. Application of Native ESI-MS to Characterize Interactions between Compounds Derived from Fragment-Based Discovery Campaigns and Two Pharmaceutically Relevant Proteins
3. Higher throughput calorimetry: opportunities, approaches and challenges
4. Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2
5. Serine is a natural ligand and allosteric activator of pyruvate kinase M2
6. Corrigendum: Serine is a natural ligand and allosteric activator of pyruvate kinase M2
7. SI_for_Application_of_Native_ESI-MS_to_FBDD_by_Gavriilidou_et_al – Supplemental material for Application of Native ESI-MS to Characterize Interactions between Compounds Derived from Fragment-Based Discovery Campaigns and Two Pharmaceutically Relevant Proteins
8. Structure–Activity and Structure–Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein–Protein Interaction
9. Structural Plasticity and Noncovalent Substrate Binding in the GroEL Apical Domain: A STUDY USING ELECTROSPRAY IONIZATION MASS SPECTROMETRY AND FLUORESCENCE BINDING STUDIES
10. Structure of GABARAP in Two Conformations: Implications for GABA A Receptor Localization and Tubulin Binding
11. Native Mass Spectrometry Gives Insight into the Allosteric Binding Mechanism of M2 Pyruvate Kinase to Fructose-1,6-Bisphosphate
12. Native Mass Spectrometry Gives Insight into the Allosteric Binding Mechanism of M2 Pyruvate Kinase to Fructose-1,6-Bisphosphate
13. Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)
14. Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives
15. Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening
16. Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery
17. Identification of novel allosteric inhibitors through fragment-based drug discovery and X-ray crystallography
18. Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors
19. Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase
20. Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
21. Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket
22. Application of Native ESI-MS to Characterize Interactions between Compounds Derived from Fragment-Based Discovery Campaigns and Two Pharmaceutically Relevant Proteins
23. Structural plasticity and non-covalent substrate binding in the GroEL apical domain: A study using electrospray ionisation mass spectrometry and fluorescence binding studies
24. Correction: Corrigendum: Serine is a natural ligand and allosteric activator of pyruvate kinase M2
25. Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
26. Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
27. Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design
28. Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency
29. Abstract A211: Fragment‐based drug discovery of the synthetic small molecule HSP90 inhibitor AT13387
30. GABARAP: Lessons for Synaptogenesis
31. An Investigation into the Properties of a Chaperone Domain and Analysis of the Non-covalently Bound Complexes with Peptide Substrates using Mass Spectrometry
32. Structural and mechanistic consequences of polypeptide binding by GroEL
33. Structure of GABARAP in Two Conformations: Implications for GABAA Receptor Localization and Tubulin Binding
34. GroEL accelerates the refolding of hen lysozyme without changing its folding mechanism.
35. Structure of GABARAP in Two Conformations Implications for GABAA Receptor Localization and Tubulin Binding
36. An All‐Metal Vacuum Valve
37. Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
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