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Inflammation of the uterine environment (commonly as a result of microbial colonisation of the fetal membranes, amniotic fluid and fetus) is strongly associated with preterm labour and birth. Both preterm birth and fetal inflammation are independently associated with elevated risks of subsequent short- and long-term respiratory, gastro-intestinal and neurological complications. Despite numerous clinical and experimental studies to investigate localised and systemic fetal inflammation following exposure to microbial agonists, there is minimal data to describe which fetal organ(s) drive systemic fetal inflammation. We used lipopolysaccharide (LPS) from E.coli in an instrumented ovine model of fetal inflammation and conducted a series of experiments to assess the systemic pro-inflammatory capacity of the three major fetal surfaces exposed to inflammatory mediators in pregnancy (the lung, gastro-intestinal tract and skin/amnion). Exposure of the fetal lung and fetal skin/amnion (but not gastro-intestinal tract) caused a significant acute systemic inflammatory response characterised by altered leucocytosis, neutrophilia, elevated plasma MCP-1 levels and inflammation of the fetal liver and spleen. These novel findings reveal differential fetal organ responses to pro-inflammatory stimulation and shed light on the pathogenesis of fetal systemic inflammation after exposure to chorioamnionitis.

This editorial discusses the challenges faced by patients and general practitioners (GPs) in accessing timely and effective mental health support in the NHS. The article highlights the "missing middle" group of patients who do not fit the criteria for primary care or secondary care services, leaving them without appropriate support. The authors propose a model of care that includes tailored training for NHS Talking Therapies clinicians, national commissioning of psychological therapies for complex mental health presentations, integrated provision of support from the voluntary sector, and liaison psychiatry services. The article emphasizes the need for validation, stability, safety, and patient agency in mental health care delivery. The authors call for increased investment and collaboration to address the treatment gap and improve mental health services. [Extracted from the article]

This paper considers the feasibility of different technologies for an electromagnetic launcher to assist civil aircraft take-off. This method is investigated to reduce the power required from the engines during initial acceleration. Assisted launch has the potential of reducing the required runway length, reducing noise near airports and improving overall aircraft efficiency through reducing engine thrust requirements. The research compares two possible linear motor topologies which may be efficaciously used for this application. The comparison is made on results from both analytical and finite element analysis (FEA).

The response in British universities to the 'troubled employee' is considered, and then contrasted with the development of Employee Assistance Programs in North American universities. Different types of programs are discussed, and it is argued that British universities might benefit from introducing such programs. (Author/EMK)