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Your search keyword '"Cox, Moniek G.P.J."' showing total 24 results
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24 results on '"Cox, Moniek G.P.J."'

1. ECG-only explainable deep learning algorithm predicts the risk for malignant ventricular arrhythmia in phospholamban cardiomyopathy

Author

van de Leur, Rutger R., de Brouwer, Remco, Bleijendaal, Hidde, Verstraelen, Tom E., Mahmoud, Belend, Perez-Matos, Ana, Dickhoff, Cathelijne, Schoonderwoerd, Bas A., Germans, Tjeerd, Houweling, Arjan, van der Zwaag, Paul A., Cox, Moniek G.P.J., Peter van Tintelen, J., te Riele, Anneline S.J.M., van den Berg, Maarten P., Wilde, Arthur A.M., Doevendans, Pieter A., de Boer, Rudolf A., and van Es, René

Published
2024
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2. Flecainide Is Associated With a Lower Incidence of Arrhythmic Events in a Large Cohort of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

Author

Bergeman, Auke T., Lieve, Krystien V.V., Kallas, Dania, Bos, J. Martijn, Rosés i Noguer, Ferran, Denjoy, Isabelle, Zorio, Esther, Kammeraad, Janneke A.E., Peltenburg, Puck J., Tobert, Katie, Aiba, Takeshi, Atallah, Joseph, Drago, Fabrizio, Batra, Anjan S., Brugada, Ramon, Borggrefe, Martin, Clur, Sally-Ann B., Cox, Moniek G.P.J., Davis, Andrew, Dhillon, Santokh, Etheridge, Susan P., Fischbach, Peter, Franciosi, Sonia, Haugaa, Kristina, Horie, Minoru, Johnsrude, Christopher, Kane, Austin M., Krause, Ulrich, Kwok, Sit-Yee, LaPage, Martin J., Ohno, Seiko, Probst, Vincent, Roberts, Jason D., Robyns, Tomas, Sacher, Frederic, Semsarian, Christopher, Skinner, Jonathan R., Swan, Heikki, Tavacova, Terezia, Tisma-Dupanovic, Svjetlana, Tfelt-Hansen, Jacob, Yap, Sing-Chien, Kannankeril, Prince J., Leenhardt, Antoine, Till, Janice, Sanatani, Shubhayan, Tanck, Michael W.T., Ackerman, Michael J., Wilde, Arthur A.M., and van der Werf, Christian

Published
2023
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3. Long-term reliability of the phospholamban (PLN) p.(Arg14del) risk model in predicting major ventricular arrhythmia:a landmark study

Author

van der Heide, Myrthe Y.C., Verstraelen, Tom E., van Lint, Freyja H.M., Bosman, Laurens P., de Brouwer, Remco, Proost, Virginnio M., van Drie, Esmée, Taha, Karim, Zwinderman, Aeilko H., Dickhoff, Cathelijne, Schoonderwoerd, Bas A., Germans, Tjeerd, Houweling, Arjan C., Gimeno-Blanes, Juan R., van der Zwaag, Paul A., de Boer, Rudolf A., Cox, Moniek G.P.J., van Tintelen, J. Peter, Wilde, Arthur A.M., van der Heide, Myrthe Y.C., Verstraelen, Tom E., van Lint, Freyja H.M., Bosman, Laurens P., de Brouwer, Remco, Proost, Virginnio M., van Drie, Esmée, Taha, Karim, Zwinderman, Aeilko H., Dickhoff, Cathelijne, Schoonderwoerd, Bas A., Germans, Tjeerd, Houweling, Arjan C., Gimeno-Blanes, Juan R., van der Zwaag, Paul A., de Boer, Rudolf A., Cox, Moniek G.P.J., van Tintelen, J. Peter, and Wilde, Arthur A.M.

Abstract

Aims:Recently, a genetic variant-specific prediction model for phospholamban (PLN) p.(Arg14del)-positive individuals was developed to predict individual major ventricular arrhythmia (VA) risk to support decision-making for primary prevention implantable cardioverter defibrillator (ICD) implantation. This model predicts major VA risk from baseline data, but iterative evaluation of major VA risk may be warranted considering that the risk factors for major VA are progressive. Our aim is to evaluate the diagnostic performance of the PLN p.(Arg14del) risk model at 3-year follow-up. Methods:We performed a landmark analysis 3 years after presentation and selected only patients with no prior major VA. Data were and results collected of 268 PLN p.(Arg14del)-positive subjects, aged 43.5 ± 16.3 years, 38.9% male. After the 3 years landmark, subjects had a mean follow-up of 4.0 years (± 3.5 years) and 28 (10%) subjects experienced major VA with an annual event rate of 2.6% [95% confidence interval (CI) 1.6–3.6], defined as sustained VA, appropriate ICD intervention, or (aborted) sudden cardiac death. The PLN p.(Arg14del) risk score yielded good discrimination in the 3 years landmark cohort with a C-statistic of 0.83 (95% CI 0.79–0.87) and calibration slope of 0.97. Conclusion:The PLN p.(Arg14del) risk model has sustained good model performance up to 3 years follow-up in PLN p.(Arg14del)positive subjects with no history of major VA. It may therefore be used to support decision-making for primary prevention ICD implantation not merely at presentation but also up to at least 3 years of follow-up.

Published
2024

4. A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers

Author

de Brouwer, Remco, te Rijdt, Wouter P., Hoorntje, Edgar T., Amin, Ahmad, Asselbergs, Folkert W., Cox, Moniek G.P.J., van der Heijden, Jeroen F., Hillege, Hans, Karper, Jacco C., Mahmoud, Belend, van der Meer, Peter, Oomen, Anton, te Riele, Anneline S.J.M., Silljé, Herman H.W., Tan, Hanno L., van Tintelen, Jan Peter, van Veldhuisen, Dirk J., Westenbrink, Berend Daan, Wiesfeld, Ans C.P., Willems, Tineke P., van der Zwaag, Paul A., Wilde, Arthur A.M., de Boer, Rudolf A., van den Berg, Maarten P., de Brouwer, Remco, te Rijdt, Wouter P., Hoorntje, Edgar T., Amin, Ahmad, Asselbergs, Folkert W., Cox, Moniek G.P.J., van der Heijden, Jeroen F., Hillege, Hans, Karper, Jacco C., Mahmoud, Belend, van der Meer, Peter, Oomen, Anton, te Riele, Anneline S.J.M., Silljé, Herman H.W., Tan, Hanno L., van Tintelen, Jan Peter, van Veldhuisen, Dirk J., Westenbrink, Berend Daan, Wiesfeld, Ans C.P., Willems, Tineke P., van der Zwaag, Paul A., Wilde, Arthur A.M., de Boer, Rudolf A., and van den Berg, Maarten P.

Abstract

Phospholamban (PLN; p.Arg14del) cardiomyopathy is an inherited disease caused by the pathogenic p.Arg14del variant in the PLN gene. Clinically, it is characterized by malignant ventricular arrhythmias and progressive heart failure.1,2 Cardiac fibrotic tissue remodelling occurs early on in PLN p.Arg14del carriers.3,4 Eplerenone was deemed a treatment candidate because of its beneficial effects on ventricular remodelling and antifibrotic properties.5,6 We conducted the multicentre randomized trial ‘intervention in PHOspholamban RElated CArdiomyopathy STudy’ (i-PHORECAST) to assess whether treatment with eplerenone of asymptomatic PLN p.Arg14del carriers attenuates disease onset and progression.

Published
2023

5. A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers

Author

Cardiologie, Team Medisch, Team Onderzoek, Circulatory Health, Onderzoek Device, Genetica, Genetica Groep Van Tintelen, Child Health, de Brouwer, Remco, te Rijdt, Wouter P., Hoorntje, Edgar T., Amin, Ahmad, Asselbergs, Folkert W., Cox, Moniek G.P.J., van der Heijden, Jeroen F., Hillege, Hans, Karper, Jacco C., Mahmoud, Belend, van der Meer, Peter, Oomen, Anton, te Riele, Anneline S.J.M., Silljé, Herman H.W., Tan, Hanno L., van Tintelen, Jan Peter, van Veldhuisen, Dirk J., Westenbrink, Berend Daan, Wiesfeld, Ans C.P., Willems, Tineke P., van der Zwaag, Paul A., Wilde, Arthur A.M., de Boer, Rudolf A., van den Berg, Maarten P., Cardiologie, Team Medisch, Team Onderzoek, Circulatory Health, Onderzoek Device, Genetica, Genetica Groep Van Tintelen, Child Health, de Brouwer, Remco, te Rijdt, Wouter P., Hoorntje, Edgar T., Amin, Ahmad, Asselbergs, Folkert W., Cox, Moniek G.P.J., van der Heijden, Jeroen F., Hillege, Hans, Karper, Jacco C., Mahmoud, Belend, van der Meer, Peter, Oomen, Anton, te Riele, Anneline S.J.M., Silljé, Herman H.W., Tan, Hanno L., van Tintelen, Jan Peter, van Veldhuisen, Dirk J., Westenbrink, Berend Daan, Wiesfeld, Ans C.P., Willems, Tineke P., van der Zwaag, Paul A., Wilde, Arthur A.M., de Boer, Rudolf A., and van den Berg, Maarten P.

Published
2023

6. Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy According to Revised 2010 Task Force Criteria With Inclusion of Non-Desmosomal Phospholamban Mutation Carriers

Author

Groeneweg, Judith A., van der Zwaag, Paul A., Olde Nordkamp, Louise R.A., Bikker, Hennie, Jongbloed, Jan D.H., Jongbloed, Roselie, Wiesfeld, Ans C.P., Cox, Moniek G.P.J., van der Heijden, Jeroen F., Atsma, Douwe E., de Boer, Karin, Doevendans, Pieter A., Vink, Aryan, van Veen, Toon A.B., Dooijes, Dennis, van den Berg, Maarten P., Wilde, Arthur A.M., van Tintelen, J. Peter, and Hauer, Richard N.

Published
2013
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7. Distinguishing Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia–Associated Mutations From Background Genetic Noise

Author

Kapplinger, Jamie D., Landstrom, Andrew P., Salisbury, Benjamin A., Callis, Thomas E., Pollevick, Guido D., Tester, David J., Cox, Moniek G.P.J., Bhuiyan, Zahir, Bikker, Hennie, Wiesfeld, Ans C.P., Hauer, Richard N.W., van Tintelen, J. Peter, Jongbloed, Jan D.H., Calkins, Hugh, Judge, Daniel P., Wilde, Arthur A.M., and Ackerman, Michael J.

Published
2011
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10. Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy

Author

van der Zwaag, Paul A., van Rijsingen, Ingrid A.W., Asimaki, Angeliki, Jongbloed, Jan D.H., van Veldhuisen, Dirk J., Wiesfeld, Ans C.P., Cox, Moniek G.P.J., van Lochem, Laura T., de Boer, Rudolf A., Hofstra, Robert M.W., Christiaans, Imke, van Spaendonck-Zwarts, Karin Y., Lekanne dit Deprez, Ronald H., Judge, Daniel P., Calkins, Hugh, Suurmeijer, Albert J.H., Hauer, Richard N.W., Saffitz, Jeffrey E., Wilde, Arthur A.M., van den Berg, Maarten P., and van Tintelen, J. Peter

Published
2012
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12. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: Proposed Modification of the Task Force Criteria

Author

Marcus, Frank I., McKenna, William J., Sherrill, Duane, Basso, Cristina, Bauce, Barbara, Bluemke, David A., Calkins, Hugh, Corrado, Domenico, Cox, Moniek G.P.J., Daubert, James P., Fontaine, Guy, Gear, Kathleen, Hauer, Richard, Nava, Andrea, Picard, Michael H., Protonotarios, Nikos, Saffitz, Jeffrey E., Sanborn, Danita M., Steinberg, Jonathan S., Tandri, Harikrishna, Thiene, Gaetano, Towbin, Jeffrey A., Tsatsopoulou, Adalena, Wichter, Thomas, and Zareba, Wojciech

Published
2010
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16. Left-dominant arrhythmogenic cardiomyopathy in a large family: Associated desmosomal or nondesmosomal genotype?

Author

Groeneweg, Judith A., primary, van der Zwaag, Paul A., additional, Jongbloed, Jan D.H., additional, Cox, Moniek G.P.J., additional, Vreeker, Arnold, additional, de Boer, Rudolf A., additional, van der Heijden, Jeroen F., additional, van Veen, Toon A.B., additional, McKenna, William J., additional, van Tintelen, J. Peter, additional, Dooijes, Dennis, additional, and Hauer, Richard N.W., additional

Published
2013
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17. Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy

Author

Noorman, Maartje, primary, Hakim, Sara, additional, Kessler, Elise, additional, Groeneweg, Judith A, additional, Cox, Moniek G.P.J., additional, Asimaki, Angeliki, additional, van Rijen, Harold V.M., additional, van Stuijvenberg, Leonie, additional, Chkourko, Halina, additional, van der Heyden, Marcel A.G., additional, Vos, Marc A., additional, de Jonge, Nicolaas, additional, van der Smagt, Jasper J., additional, Dooijes, Dennis, additional, Vink, Aryan, additional, de Weger, Roel A., additional, Varro, Andras, additional, de Bakker, Jacques M.T., additional, Saffitz, Jeffrey E., additional, Hund, Thomas J., additional, Mohler, Peter J., additional, Delmar, Mario, additional, Hauer, Richard N.W., additional, and van Veen, Toon A.B., additional

Published
2013
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18. Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Author

Cox, Moniek G.P.J., primary, van der Zwaag, Paul A., additional, van der Werf, Christian, additional, van der Smagt, Jasper J., additional, Noorman, Maartje, additional, Bhuiyan, Zahir A., additional, Wiesfeld, Ans C.P., additional, Volders, Paul G.A., additional, van Langen, Irene M., additional, Atsma, Douwe E., additional, Dooijes, Dennis, additional, van den Wijngaard, Arthur, additional, Houweling, Arjan C., additional, Jongbloed, Jan D.H., additional, Jordaens, Luc, additional, Cramer, Maarten J., additional, Doevendans, Pieter A., additional, de Bakker, Jacques M.T., additional, Wilde, Arthur A.M., additional, van Tintelen, J. Peter, additional, and Hauer, Richard N.W., additional

Published
2011
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19. Genotype-Phenotype Analysis in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy: Follow-Up of a Large Series of Dutch Index-Patients and Family Members

Author

Cox, Moniek G.P.J., primary, van der Zwaag, Paul A., additional, van der Werf, Christian, additional, van der Smagt, Jasper J., additional, Noorman, Maartje, additional, Bhuiyan, Zahir A., additional, Wiesfeld, Ans C.P., additional, Volders, Paul G.A., additional, van Langen, Irene M., additional, Atsma, Douwe E., additional, Dooijes, Dennis, additional, van de Wijngaard, Arthur, additional, Houweling, Arjan C., additional, Jongbloed, Jan D.H., additional, Jordaens, Luc, additional, Cramer, Maarten J., additional, Doevendans, Pieter A., additional, de Bakker, Jacques M.T., additional, Wilde, Arthur A.M., additional, van Tintelen, J. Peter, additional, and Hauer, Richard N.W., additional

Published
2010
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20. Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

Author

Marcus, Frank I., primary, McKenna, William J., additional, Sherrill, Duane, additional, Basso, Cristina, additional, Bauce, Barbara, additional, Bluemke, David A., additional, Calkins, Hugh, additional, Corrado, Domenico, additional, Cox, Moniek G.P.J., additional, Daubert, James P., additional, Fontaine, Guy, additional, Gear, Kathleen, additional, Hauer, Richard, additional, Nava, Andrea, additional, Picard, Michael H., additional, Protonotarios, Nikos, additional, Saffitz, Jeffrey E., additional, Sanborn, Danita M. Yoerger, additional, Steinberg, Jonathan S., additional, Tandri, Harikrishna, additional, Thiene, Gaetano, additional, Towbin, Jeffrey A., additional, Tsatsopoulou, Adalena, additional, Wichter, Thomas, additional, and Zareba, Wojciech, additional

Published
2010
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21. Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Diagnostic Task Force Criteria

Author

Cox, Moniek G.P.J., primary, van der Smagt, Jasper J., additional, Noorman, Maartje, additional, Wiesfeld, Ans C., additional, Volders, Paul G.A., additional, van Langen, Irene M., additional, Atsma, Douwe E., additional, Dooijes, Dennis, additional, Houweling, Arjan C., additional, Loh, Peter, additional, Jordaens, Luc, additional, Arens, Yvonne, additional, Cramer, Maarten J., additional, Doevendans, Pieter A., additional, van Tintelen, J. Peter, additional, Wilde, Arthur A.M., additional, and Hauer, Richard N.W., additional

Published
2010
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22. New ECG Criteria in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Author

Cox, Moniek G.P.J., primary, van der Smagt, Jasper J., additional, Wilde, Arthur A.M., additional, Wiesfeld, Ans C.P., additional, Atsma, Douwe E., additional, Nelen, Marcel R., additional, Rodriguez, Luz-Maria, additional, Loh, Peter, additional, Cramer, Maarten J., additional, Doevendans, Pieter A., additional, van Tintelen, J. Peter, additional, de Bakker, Jacques M.T., additional, and Hauer, Richard N.W., additional

Published
2009
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23. Desmoglein-2 and Desmocollin-2 Mutations in Dutch Arrhythmogenic Right Ventricular Dysplasia/Cardiomypathy Patients

Author

Bhuiyan, Zahurul A., primary, Jongbloed, Jan D.H., additional, van der Smagt, Jasper, additional, Lombardi, Paola M., additional, Wiesfeld, Ans C.P., additional, Nelen, Marcel, additional, Schouten, Meyke, additional, Jongbloed, Roselie, additional, Cox, Moniek G.P.J., additional, van Wolferen, Marleen, additional, Rodriguez, Luz M., additional, van Gelder, Isabelle C., additional, Bikker, Hennie, additional, Suurmeijer, Albert J.H., additional, van den Berg, Maarten P., additional, Mannens, Marcel M.A.M., additional, Hauer, Richard N.W., additional, Wilde, Arthur A.M., additional, and van Tintelen, J. Peter, additional

Published
2009
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