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1. Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial

Author

Radavelli-Bagatini, Simone, Bondonno, Catherine P., Dalla Via, Jack, Sim, Marc, Gebre, Abadi K., Blekkenhorst, Lauren C., Connolly, Emma L., Bondonno, Nicola P., Schousboe, John T., Woodman, Richard J., Zhu, Kun, Mullin, Shelby, Szulc, Pawel, Jackson, Ben, Dimmock, James, Schlaich, Markus P., Cox, Kay L., Kiel, Douglas P., Lim, Wai H., Stanley, Mandy, Devine, Amanda, Thompson, Peter L., Williams, Evan J., Wood, Lisa G., Sim, Moira, Daly, Robin M., Hodgson, Jonathan M., and Lewis, Joshua R.

Published
2024
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6. Designing EXercise for Cognitive hEalth in depression and anxiety: the EXCEL study

Author

Curran, Eleanor, primary, Ellis, Kathryn A, additional, Palmer, Victoria J, additional, Cox, Kay L, additional, Chong, Terence W.H, additional, Rego, Thomas W H, additional, Anstey, Kaarin J., additional, Southam, Jennifer Amanda, additional, Moorhead, Rebecca Anne, additional, Westphal, Alissa, additional, Lai, Rhoda, additional, and Lautenschlager, Nicola T, additional

Published
2023
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9. EXCEL ‐ EXercise for Cognitive hEaLth: A pilot 12‐week online home‐based physical activity program for middle‐aged and older adults with cognitive and mental health concerns.

Author

Ellis, Kathryn A, primary, Curran, Eleanor, additional, Moorhead, Rebecca Anne, additional, Cox, Kay L, additional, Southam, Jennifer Amanda, additional, Westphal, Alissa, additional, Lai, Rhoda, additional, Rego, Thomas W H, additional, Palmer, Victoria J, additional, Anstey, Kaarin J., additional, Coulson, Brett, additional, Lautenschlager, Nicola T, additional, and Moss, Francine, additional

Published
2023
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13. An Internet-Based Intervention Augmented With a Diet and Physical Activity Consultation to Decrease the Risk of Dementia in At-Risk Adults in a Primary Care Setting: Pragmatic Randomized Controlled Trial

Author

Anstey, Kaarin J, Cherbuin, Nicolas, Kim, Sarang, McMaster, Mitchell, D'Este, Catherine, Lautenschlager, Nicola, Rebok, George, McRae, Ian, Torres, Susan J, Cox, Kay L, and Pond, Constance Dimity

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundThere is a need to develop interventions to reduce the risk of dementia in the community by addressing lifestyle factors and chronic diseases over the adult life course. ObjectiveThis study aims to evaluate a multidomain dementia risk reduction intervention, Body Brain Life in General Practice (BBL-GP), targeting at-risk adults in primary care. MethodsA pragmatic, parallel, three-arm randomized trial involving 125 adults aged 18 years or older (86/125, 68.8% female) with a BMI of ≥25 kg/m2 or a chronic health condition recruited from general practices was conducted. The arms included (1) BBL-GP, a web-based intervention augmented with an in-person diet and physical activity consultation; (2) a single clinician–led group, Lifestyle Modification Program (LMP); and (3) a web-based control. The primary outcome was the Australian National University Alzheimer Disease Risk Index Short Form (ANU-ADRI-SF). ResultsBaseline assessments were conducted on 128 participants. A total of 125 participants were randomized to 3 groups (BBL-GP=42, LMP=41, and control=42). At immediate, week 18, week 36, and week 62 follow-ups, the completion rates were 43% (18/42), 57% (24/42), 48% (20/42), and 48% (20/42), respectively, for the BBL-GP group; 71% (29/41), 68% (28/41), 68% (28/41), and 51% (21/41), respectively, for the LMP group; and 62% (26/42), 69% (29/42), 60% (25/42), and 60% (25/42), respectively, for the control group. The primary outcome of the ANU-ADRI-SF score was lower for the BBL-GP group than the control group at all follow-ups. These comparisons were all significant at the 5% level for estimates adjusted for baseline differences (immediate: difference in means −3.86, 95% CI −6.81 to −0.90, P=.01; week 18: difference in means −4.05, 95% CI −6.81 to −1.28, P

Published
2020
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14. Physical Activity for Cognitive Health: A Model for Intervention Design for People Experiencing Cognitive Concerns and Symptoms of Depression or Anxiety

Author

Curran, Eleanor, primary, Palmer, Victoria J., additional, Ellis, Kathryn A., additional, Chong, Terence W.H., additional, Rego, Thomas, additional, Cox, Kay L., additional, Anstey, Kaarin J., additional, Westphal, Alissa, additional, Moorhead, Rebecca, additional, Southam, Jenny, additional, Lai, Rhoda, additional, You, Emily, additional, and Lautenschlager, Nicola T., additional

Published
2023
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16. Co‐design of dementia prevention program for Aboriginal Australians (DAMPAA)

Author

Mateo‐Arriero, Irene, primary, Lalovic, Alexander, additional, Dowden, Glennette, additional, Markey, Lesley, additional, Cox, Kay L., additional, Flicker, Leon, additional, Bessarab, Dawn, additional, Thompson, Sandra, additional, Kickett, Carmel, additional, Woods, Deborah, additional, Pestell, Carmela F., additional, Edgill, Paula, additional, Etherton‐Beer, Christopher, additional, and Smith, Kate, additional

Published
2023
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17. Factors Influencing Long-Term Physical Activity Maintenance: A Qualitative Evaluation of a Physical Activity Program for Inactive Older Adults at Risk of Cognitive Decline: The INDIGO Follow-Up Study

Author

Chong, Terence W.H., primary, Curran, Eleanor, additional, Southam, Jenny, additional, Cox, Kay L., additional, Bryant, Christina, additional, Goh, Anita M.Y., additional, You, Emily, additional, Ellis, Kathryn A., additional, and Lautenschlager, Nicola T., additional

Published
2022
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20. sj-docx-1-tpp-10.1177_20451253221104958 – Supplemental material for Exercise interventions to reduce anxiety in mid-life and late-life anxiety disorders and subthreshold anxiety disorder: a systematic review

Author

Chong, Terence W.H., Kootar, Scherazad, Wilding, Helen, Berriman, Sarah, Curran, Eleanor, Cox, Kay L., Bahar-Fuchs, Alex, Peters, Ruth, Anstey, Kaarin J., Bryant, Christina, and Lautenschlager, Nicola T.

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tpp-10.1177_20451253221104958 for Exercise interventions to reduce anxiety in mid-life and late-life anxiety disorders and subthreshold anxiety disorder: a systematic review by Terence W.H. Chong, Scherazad Kootar, Helen Wilding, Sarah Berriman, Eleanor Curran, Kay L. Cox, Alex Bahar-Fuchs, Ruth Peters, Kaarin J. Anstey, Christina Bryant and Nicola T. Lautenschlager in Therapeutic Advances in Psychopharmacology

Published
2022
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21. Exercise interventions to reduce anxiety in mid-life and late-life anxiety disorders and subthreshold anxiety disorder: a systematic review

Author

Chong, Terence W.H., primary, Kootar, Scherazad, additional, Wilding, Helen, additional, Berriman, Sarah, additional, Curran, Eleanor, additional, Cox, Kay L., additional, Bahar-Fuchs, Alex, additional, Peters, Ruth, additional, Anstey, Kaarin J., additional, Bryant, Christina, additional, and Lautenschlager, Nicola T., additional

Published
2022
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24. A Randomized Controlled Trial on the Effects of a 6-Month Home-Based Physical Activity Program with Individual Goal-Setting and Volunteer Mentors on Physical Activity, Adherence, and Physical Fitness in Inactive Older Adults at Risk of Cognitive Decline: The INDIGO Study

Author

Cox, Kay L., primary, Clare, Linda, additional, Cyarto, Elizabeth V., additional, Ellis, Kathryn A., additional, Etherton-Beer, Christopher, additional, Southam, Jenny, additional, Ames, David, additional, Flicker, Leon, additional, Almeida, Osvaldo P., additional, LoGiudice, Dina, additional, Liew, Danny, additional, Vlaskovsky, Philip, additional, and Lautenschlager, Nicola T., additional

Published
2021
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25. The support person's preferences and perspectives of physical activity programs for older adults with cognitive impairment

Author

Chong, Terence W. H., You, Emily, Ellis, Kathryn A., Cox, Kay L., Harrington, Karra D., Rainey-Smith, Stephanie R., Ames, David, Lautenschlager, Nicola T., AIBL Research Group, Chong, Terence W. H., You, Emily, Ellis, Kathryn A., Cox, Kay L., Harrington, Karra D., Rainey-Smith, Stephanie R., Ames, David, Lautenschlager, Nicola T., and AIBL Research Group

Abstract

Objectives: Physical activity (PA) is beneficial for older adults' cognition. There is limited research investigating perspectives of support persons (SPs) of next-of-kins (NOKs) with cognitive impairment. This exploratory study aimed to investigate perspectives of SPs of older adults with Alzheimer's Dementia (AD) or Mild Cognitive Impairment (MCI). Methods: A telephone survey of 213 SPs of NOKs from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) was undertaken to quantitatively assess SPs' beliefs and knowledge about PA benefits, current PA level of their NOK, and PA program preferences. The contribution of age, gender, diagnosis and mental health symptoms was assessed using multiple logistic regression analyses. Results: Many SPs were aware of PA benefits for memory (64%) and believed it would help their NOK (72%). Older SP age was associated with less awareness of benefits (p = 0.016). SPs caring for male NOKs were more likely to believe that PA would be helpful than those caring for female NOKs (p = 0.049). NOK AD diagnosis (rather than MCI) (p = 0.014), older age (p = 0.005) and female gender (p = 0.043) were associated with lower PA levels. SPs were mixed regarding preference for their NOKs to participate in individual (45%) or group (54%) PA. Many SPs wanted to participate in PA with their NOK (63%). Conclusions: The results highlight that SPs have high levels of awareness of the cognitive benefits of PA, and describe their preferences regarding PA programs. The findings provide new information to inform targeted public health messaging, PA prescribers and providers, and future research directions.

Published
2021

27. Effect of a 24-month physical activity program on brain changes in older adults at risk of Alzheimer's disease: the AIBL active trial

Author

Venkatraman, Vijay K., Sanderson, Andrew, Cox, Kay L., Ellis, Kathryn A., Steward, Christopher, Phal, Pramit M., Gorelik, Alexandra, Sharman, Matthew J., Villemagne, Victor L., Lai, Michelle, Cyarto, Elizabeth V., Merkel, Bernd, Ames, David, Szoeke, Cassandra, Rowe, Christopher C., Masters, Colin L., Lautenschlager, Nicola T., and Desmond, Patricia M.

Published
2020
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30. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial

Author

Lautenschlager, Nicola T., Flicker, Leon, Cox, Kay L., Foster, Jonathan K., Almeida, Osvaldo P., van Bockxmeer, Frank M., Greenop, Kathryn R., and Jianguo Xiao

Subjects
Alzheimer's disease -- Research, Alzheimer's disease -- Risk factors
Abstract

A study was conducted to determine the beneficial effects of physical activity on the incidence of Alzheimer's disease (AD). Results revealed that adults manifesting a memory loss and subjected to physical activity displayed considerable improvement over a period of time.

Published
2008

31. Modification of diet, exercise and lifestyle (MODEL) study: A randomised controlled trial protocol

Author

Radavelli-Bagatini, Simone, Bondonno, Catherine P., Sim, Marc, Blekkenhorst, Lauren C., Anokye, Reindolf, Connolly, Emma, Bondonno, Nicola P., Schousboe, John T., Woodman, Richard J., Zhu, Kun, Szulc, Pawel, Jackson, Ben, Dimmock, James, Schlaich, Markus P., Cox, Kay L., Kiel, Douglas P., Lim, Wai H., Stanley, Mandy, Devine, Amanda, Thompson, Peter L., Gianoudis, Jenny, De Ross, Belinda, Daly, Robin M., Lewis, Joshua, Hodgson, Jonathan M., Radavelli-Bagatini, Simone, Bondonno, Catherine P., Sim, Marc, Blekkenhorst, Lauren C., Anokye, Reindolf, Connolly, Emma, Bondonno, Nicola P., Schousboe, John T., Woodman, Richard J., Zhu, Kun, Szulc, Pawel, Jackson, Ben, Dimmock, James, Schlaich, Markus P., Cox, Kay L., Kiel, Douglas P., Lim, Wai H., Stanley, Mandy, Devine, Amanda, Thompson, Peter L., Gianoudis, Jenny, De Ross, Belinda, Daly, Robin M., Lewis, Joshua, and Hodgson, Jonathan M.

Abstract

Introduction Most cardiovascular disease (CVD)-related events could be prevented or substantially delayed with improved diet and lifestyle. Providing information on structural vascular disease may improve CVD risk factor management, but its impact on lifestyle change remains unclear. This study aims to determine whether providing visualisation and pictorial representation of structural vascular disease (abdominal aortic calcification (AAC)) can result in healthful diet and lifestyle change. Methods and analysis This study, including men and women aged 60–80 years, is a 12-week, two-arm, multisite randomised controlled trial. At baseline, all participants will have AAC assessed from a lateral spine image captured using a bone densitometer. Participants will then be randomised to receive their AAC results at baseline (intervention group) or a usual care control group that will receive their results at 12 weeks. All participants will receive information about routinely assessed CVD risk factors and standardised (video) diet and lifestyle advice with three simple goals: (1) increase fruit and vegetable (FV) intake by at least one serve per day, (2) improve other aspects of the diet and (3) reduce sitting time and increase physical activity. Clinical assessments will be performed at baseline and 12 weeks. Outcomes The primary outcome is a change in serum carotenoid concentrations as an objective measure of FV intake. The study design, procedures and treatment of data will adhere to Standard Protocol Items for Randomized Trials guidelines.

Published
2020

32. Implementation, mechanisms of impact and key contextual factors involved in outcomes of the Modification of Diet, Exercise and Lifestyle (MODEL) randomised controlled trial in Australian adults: Protocol for a mixed-method process evaluation

Author

Anokye, Reindolf, Radavelli-Bagatini, Simone, Bondonno, Catherine P., Sim, Marc, Blekkenhorst, Lauren C., Connolly, Emma, Bondonno, Nicola P., Schousboe, John T., Woodman, Richard, Zhu, Kun, Zhu, Pawel, Jackson, Ben, Dimmock, James, Schlaich, Markus P., Cox, Kay L., Kiel, Douglas P., Lim, Wai H., Devine, Amanda, Thompson, Peter L., Gianoudis, Jenny, De Ross, Belinda, Daly, Robin M., Hodgson, Jonathan M., Lewis, Joshua, Stanley, Mandy, Anokye, Reindolf, Radavelli-Bagatini, Simone, Bondonno, Catherine P., Sim, Marc, Blekkenhorst, Lauren C., Connolly, Emma, Bondonno, Nicola P., Schousboe, John T., Woodman, Richard, Zhu, Kun, Zhu, Pawel, Jackson, Ben, Dimmock, James, Schlaich, Markus P., Cox, Kay L., Kiel, Douglas P., Lim, Wai H., Devine, Amanda, Thompson, Peter L., Gianoudis, Jenny, De Ross, Belinda, Daly, Robin M., Hodgson, Jonathan M., Lewis, Joshua, and Stanley, Mandy

Abstract

Introduction The Modification of Diet, Exercise and Lifestyle (MODEL) study aims to examine the impact of providing visualisation and pictorial representation of advanced structural vascular disease (abdominal aortic calcification), on ‘healthful’ improvements to diet and lifestyle. This paper reports the protocol for the process evaluation for the MODEL study. Methods and analysis The overall aim of the process evaluation is to understand the processes that took place during participation in the MODEL study trial and which elements were effective or ineffective for influencing ‘healthful’ behavioural change, and possible ways of improvement to inform wider implementation strategies. A mixed-method approach will be employed with the use of structured questionnaires and semistructured in-depth interviews. All 200 participants enrolled in the trial will undertake the quantitative component of the study and maximum variation sampling will be used to select a subsample for the qualitative component. The sample size for the qualitative component will be determined based on analytical saturation. Interviews will be digitally recorded and transcribed verbatim. Qualitative data will be analysed thematically and reported according to the Consolidated Criteria for Reporting Qualitative Research (COREQ) guidelines. Ethics and dissemination The MODEL study process evaluation has received approval from Edith Cowan University Human Research Ethics Committee (Project Number: 20513 HODGSON). Written informed consent will be obtained from all participants before they are included in the study. The study results will be shared with the individuals and institutions associated with this study as well as academic audiences through peer-reviewed publication and probable presentation at conferences.

Published
2020

33. Protocol of a clinical trial to implement physical activity for cognitive health in two aged persons' mental health services in Melbourne: The EXCEL study

Author

Ellis, Kathryn A, primary, Curran, Eleanor, additional, Cox, Kay L, additional, Chong, Terence WH, additional, Palmer, Victoria J, additional, Anstey, Kaarin J, additional, Southam, Jennifer, additional, Coulson, Brett, additional, Moss, Francine, additional, and Lautenschlager, Nicola T, additional

Published
2020
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35. Comparison of peer mentoring versus peer support in a 6‐month home‐based physical activity program for inactive older adults at risk of Alzheimer’s disease: Experiences from the INDIGO trial

Author

Cox, Kay L, primary, Ellis, Kathryn A, additional, Clare, Linda, additional, Cyarto, Elizabeth V, additional, Etherton‐Beer, Christopher, additional, Ames, David, additional, Flicker, Leon, additional, Almeida, Osvaldo P, additional, LoGiudice, Dina, additional, Liew, Danny, additional, Southam, Jennifer, additional, and Lautenschlager, Nicola T, additional

Published
2020
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37. Modification of diet, exercise and lifestyle (MODEL) study: a randomised controlled trial protocol

Author

Radavelli-Bagatini, Simone, primary, Bondonno, Catherine P, additional, Sim, Marc, additional, Blekkenhorst, Lauren C, additional, Anokye, Reindolf, additional, Connolly, Emma, additional, Bondonno, Nicola P, additional, Schousboe, John T, additional, Woodman, Richard J, additional, Zhu, Kun, additional, Szulc, Pawel, additional, Jackson, Ben, additional, Dimmock, James, additional, Schlaich, Markus P, additional, Cox, Kay L, additional, Kiel, Douglas P, additional, Lim, Wai H, additional, Stanley, Mandy, additional, Devine, Amanda, additional, Thompson, Peter L, additional, Gianoudis, Jenny, additional, De Ross, Belinda, additional, Daly, Robin M, additional, Lewis, Joshua R, additional, and Hodgson, Jonathan M, additional

Published
2020
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38. Implementation, mechanisms of impact and key contextual factors involved in outcomes of the Modification of Diet, Exercise and Lifestyle (MODEL) randomised controlled trial in Australian adults: protocol for a mixed-method process evaluation

Author

Anokye, Reindolf, primary, Radavelli-Bagatini, Simone, additional, Bondonno, Catherine P, additional, Sim, Marc, additional, Blekkenhorst, Lauren C, additional, Connolly, Emma, additional, Bondonno, Nicola P, additional, Schousboe, John T, additional, Woodman, Richard, additional, Zhu, Kun, additional, Szulc, Pawel, additional, Jackson, Ben, additional, Dimmock, James, additional, Schlaich, Markus P, additional, Cox, Kay L, additional, Kiel, Douglas P, additional, Lim, Wai H, additional, Devine, Amanda, additional, Thompson, Peter L, additional, Gianoudis, Jenny, additional, De Ross, Belinda, additional, Daly, Robin M, additional, Hodgson, Jonathan M, additional, Lewis, Joshua R, additional, and Stanley, Mandy, additional

Published
2020
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39. Baseline White Matter Is Associated With Physical Fitness Change in Preclinical Alzheimer’s Disease

Author

Venkatraman, Vijay K., primary, Steward, Christopher E., additional, Cox, Kay L., additional, Ellis, Kathryn A., additional, Phal, Pramit M., additional, Sharman, Matthew J., additional, Villemagne, Victor L., additional, Lai, Michelle M. Y., additional, Cyarto, Elizabeth V., additional, Ames, David, additional, Szoeke, Cassandra, additional, Rowe, Christopher C., additional, Masters, Colin L., additional, Lautenschlager, Nicola T., additional, and Desmond, Patricia M., additional

Published
2020
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40. An Internet-Based Intervention Augmented With a Diet and Physical Activity Consultation to Decrease the Risk of Dementia in At-Risk Adults in a Primary Care Setting: Pragmatic Randomized Controlled Trial (Preprint)

Author

Anstey, Kaarin J, primary, Cherbuin, Nicolas, additional, Kim, Sarang, additional, McMaster, Mitchell, additional, D'Este, Catherine, additional, Lautenschlager, Nicola, additional, Rebok, George, additional, McRae, Ian, additional, Torres, Susan J, additional, Cox, Kay L, additional, and Pond, Constance Dimity, additional

Published
2020
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41. Relationship of Established Cardiovascular Risk Factors and Peripheral Biomarkers on Cognitive Function in Adults at Risk of Cognitive Deterioration

Author

Lai, Michelle M.Y., primary, Sharman, Matthew J., additional, Ames, David J., additional, Ellis, Kathryn A., additional, Cox, Kay L., additional, Hepworth, Graham, additional, Desmond, Patricia, additional, Cyarto, Elizabeth V., additional, Martins, Ralph N., additional, Masters, Colin L., additional, and Lautenschlager, Nicola T., additional

Published
2020
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44. Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline among Community Dwelling 55 to 77 Year Olds

Author

Heffernan, Megan, Andrews, Gavin, Fiatarone Singh, Maria A., Valenzuela, Michael, Anstey, Kaarin J., Maeder, Anthony J., McNeil, John, Jorm, Louisa, Lautenschlager, Nicola T., Sachdev, Perminder S., Ginige, Jeewani A., Hobbs, Megan J., Boulamatsis, Christos, Chau, Tiffany, Cobiac, Lynne, Cox, Kay L., Daniel, Kenneth, Flood, Victoria M., Guerrero, Yareni, Gunn, Jane, Jain, Nidhi, Kochan, Nicole A., Lampit, Amit, Mavros, Yorgi, Meiklejohn, Jacinda, Noble, Yian, O'Leary, Fiona, Radd-Vagenas, Sue, Walton, Courtney C., Brodaty, Henry, Heffernan, Megan, Andrews, Gavin, Fiatarone Singh, Maria A., Valenzuela, Michael, Anstey, Kaarin J., Maeder, Anthony J., McNeil, John, Jorm, Louisa, Lautenschlager, Nicola T., Sachdev, Perminder S., Ginige, Jeewani A., Hobbs, Megan J., Boulamatsis, Christos, Chau, Tiffany, Cobiac, Lynne, Cox, Kay L., Daniel, Kenneth, Flood, Victoria M., Guerrero, Yareni, Gunn, Jane, Jain, Nidhi, Kochan, Nicole A., Lampit, Amit, Mavros, Yorgi, Meiklejohn, Jacinda, Noble, Yian, O'Leary, Fiona, Radd-Vagenas, Sue, Walton, Courtney C., and Brodaty, Henry

Abstract

Background: Maintain Your Brain (MYB) is a randomized controlled trial of an online multi-modal lifestyle intervention targeting modifiable dementia risk factors with its primary aim being to reduce cognitive decline in an older age cohort. Methods: MYB aims to recruit 8,500 non-demented community dwelling 55 to 77 year olds from the Sax Institute's 45 and Up Study in New South Wales, Australia. Participants will be screened for risk factors related to four modules that comprise the MYB intervention: physical activity, nutrition, mental health, and cognitive training. Targeting risk factors will enable interventions to be personalized so that participants receive the most appropriate modules. MYB will run for three years and up to four modules will be delivered sequentially each quarter during year one. Upon completing a module, participants will continue to receive less frequent booster activities for their eligible modules (except for the mental health module) until the end of the trial. Discussion: MYB will be the largest internet-based trial to attempt to prevent cognitive decline and potentially dementia. If successful, MYB will provide a model for not just effective intervention among older adults, but an intervention that is scalable for broad use.

Published
2019

45. Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial

Author

Cyarto Elizabeth V, Lautenschlager Nicola T, Desmond Patricia M, Ames David, Szoeke Cassandra, Salvado Olivier, Sharman Matthew J, Ellis Kathryn A, Phal Pramit M, Masters Colin L, Rowe Christopher C, Martins Ralph N, and Cox Kay L

Subjects
Psychiatry, RC435-571
Abstract

Abstract Background Older adults free of dementia but with subjective memory complaints (SMC) or mild cognitive impairment (MCI) are considered at increased risk of cognitive decline. Vascular risk factors (VRF), including hypertension, heart disease, smoking, hypercholesterolemia and lack of physical activity (PA) have been identified as modifiable risk factors contributing to cognitive decline, and white matter hyperintensities (WMH) are associated with VRF, SMC and cognitive impairment. Findings from a growing number of clinical trials with older adults are providing strong evidence for the benefits of physical activity for maintaining cognitive function, but few studies are investigating these benefits in high-risk populations. The aim of AIBL Active is to determine whether a 24-month physical activity program can delay the progression of white matter changes on magnetic resonance imaging (MRI). Methods/design This single-blind randomized controlled trial (RCT) is offered to 156 participants, aged 60 and older, in the Melbourne arm of the Australian Imaging Biomarkers and Lifestyle Flagship Study of Aging (AIBL). Participants must have SMC with or without MCI and at least one VRF. The PA intervention is a modification of the intervention previously trialed in older adults with SMC and MCI (Fitness for the Ageing Brain Study). It comprises 24 months of moderate, home-based PA (150 minutes per week) and a behavioral intervention package. The primary outcome measure will be change in WMH after 24 months on MRI. Cognition, quality of life, functional fitness, level of physical activity, plasma biomarkers for cerebrovascular disease and amyloid positron emission tomography (PET) imaging comprise secondary measures. Discussion Currently, there is no effective pharmacological treatment available to delay cognitive decline and dementia in older adults at risk. Should our findings show that physical activity can slow down the progression of WMH, this RCT would provide an important proof of concept. Since imbedded in AIBL this RCT will also be able to investigate the interaction between vascular and Alzheimer's disease pathologies. Trial Registration Australia New Zealand Clinical Trials Registry ACTRN12611000612910

Published
2012
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46. A Randomized Controlled Trial of Adherence to a 24-Month Home-Based Physical Activity Program and the Health Benefits for Older Adults at Risk of Alzheimer’s Disease: The AIBL Active-Study

Author

Cox, Kay L., primary, Cyarto, Elizabeth V., additional, Ellis, Kathryn A., additional, Ames, David, additional, Desmond, Patricia, additional, Phal, Pramit, additional, Sharman, Matthew J., additional, Szoeke, Cassandra, additional, Rowe, Christopher C., additional, Masters, Colin L., additional, You, Emily, additional, Burrows, Sally, additional, Lai, Michelle M.Y., additional, and Lautenschlager, Nicola T., additional

Published
2019
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49. The fitness for the Ageing Brain Study II (FABS II): protocol for a randomized controlled clinical trial evaluating the effect of physical activity on cognitive function in patients with Alzheimer's disease

Author

Ames David, Flicker Leon, Almeida Osvaldo P, Cox Kay L, Cyarto Elizabeth V, Byrne Gerard, Hill Keith D, Beer Christopher D, LoGiudice Dina, Appadurai Kana, Irish Muireann, Renehan Emma, and Lautenschlager Nicola T

Subjects
Medicine (General), R5-920
Abstract

Abstract Background Observational studies have documented a potential protective effect of physical exercise in older adults who are at risk for developing Alzheimer's disease. The Fitness for the Ageing Brain II (FABS II) study is a multicentre randomized controlled clinical trial (RCT) aiming to determine whether physical activity reduces the rate of cognitive decline among individuals with Alzheimer's disease. This paper describes the background, objectives of the study, and an overview of the protocol including design, organization and data collection methods. Methods/Design The study will recruit 230 community-dwelling participants diagnosed with Alzheimer's disease. Participants will be randomly allocated to two treatment groups: usual care group or 24-week home-based program consisting of 150 minutes per week of tailored moderate physical activity. The primary outcome measure of the study is cognitive decline as measured by the change from baseline in the total score on the Alzheimer's disease Assessment Scale-Cognitive section. Secondary outcomes of interest include behavioral and psychological symptoms, quality of life, functional level, carer burden and physical function (strength, balance, endurance, physical activity). Primary endpoints will be measured at six and twelve months following the baseline assessment. Discussion This RCT will contribute evidence regarding the potential benefits of a systematic program of physical activity as an affordable and safe intervention for people with Alzheimer's disease. Further, if successful, physical activity in combination with usual care has the potential to alleviate the symptoms of Alzheimer's disease and improve its management and the quality of life of patients and their carers. Trial Registration Australia New Zealand Clinical Trials Registry ACTRN12609000755235

Published
2010
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50. Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease

Author

Kerestes, Rebecca, Phal, Pramit M., Steward, Chris, Moffat, Bradford A., Salinas, Simon, Cox, Kay L., Ellis, Kathryn A., Cyarto, Elizabeth V., Ames, David, Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Sharman, Matthew J., Salvado, Olivier, Szoeke, Cassandra, Lai, Michelle, Lautenschlager, Nicola T., Desmond, Patricia M., Kerestes, Rebecca, Phal, Pramit M., Steward, Chris, Moffat, Bradford A., Salinas, Simon, Cox, Kay L., Ellis, Kathryn A., Cyarto, Elizabeth V., Ames, David, Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Sharman, Matthew J., Salvado, Olivier, Szoeke, Cassandra, Lai, Michelle, Lautenschlager, Nicola T., and Desmond, Patricia M.

Abstract

Background Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns. Aims To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE 4) allele. Method Participants were 22 SMC carrying the APOE ɛ4 allele (ɛ4+; mean age 72.18 years) and 58 SMC non-carriers (ɛ4–; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored. Results ɛ4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC–SMA connectivity. Conclusions The results provide the first evidence that ɛ4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity.

Published
2018

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