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364 results on '"Cowley, Glenn S."'

1. Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin

Author

Mittal, Karuna, Cooper, Garrett W., Lee, Benjamin P., Su, Yongdong, Skinner, Katie T., Shim, Jenny, Jonus, Hunter C., Kim, Won Jun, Doshi, Mihir, Almanza, Diego, Kynnap, Bryan D., Christie, Amanda L., Yang, Xiaoping, Cowley, Glenn S., Leeper, Brittaney A., Morton, Christopher L., Dwivedi, Bhakti, Lawrence, Taylor, Rupji, Manali, Keskula, Paula, Meyer, Stephanie, Clinton, Catherine M., Bhasin, Manoj, Crompton, Brian D., Tseng, Yuen-Yi, Boehm, Jesse S., Ligon, Keith L., Root, David E., Murphy, Andrew J., Weinstock, David M., Gokhale, Prafulla C., Spangle, Jennifer M., Rivera, Miguel N., Mullen, Elizabeth A., Stegmaier, Kimberly, Goldsmith, Kelly C., Hahn, William C., and Hong, Andrew L.

Published
2024
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2. Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias

Author

Kwon, Min Chul, Thuring, Jan Willem, Querolle, Olivier, Dai, Xuedong, Verhulst, Tinne, Pande, Vineet, Marien, Ann, Goffin, Dries, Wenge, Daniela V., Yue, Hong, Cutler, Jevon A., Jin, Cyrus, Perner, Florian, Hogeling, Shanna M., Shaffer, Paul L., Jacobs, Frank, Vinken, Petra, Cai, Wei, Keersmaekers, Vikki, Eyassu, Filmon, Bhogal, Balpreet, Verstraeten, Karin, El Ashkar, Sara, Perry, Jennifer A., Jayaguru, Prathiba, Barreyro, Laura, Kuchnio, Anna, Darville, Nicolas, Krosky, Daniel, Urbanietz, Gregor, Verbist, Bie, Edwards, James P., Cowley, Glenn S., Kirkpatrick, Robert, Steele, Ruth, Ferrante, Lucille, Guttke, Christina, Daskalakis, Nikki, Pietsch, E. Christine, Wilson, David M., Attar, Ricardo, Elsayed, Yusri, Fischer, Eric S., Schuringa, Jan Jacob, Armstrong, Scott A., Packman, Kathryn, and Philippar, Ulrike

Published
2024
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3. SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation

Author

Chang, Yu-Hsuan, Yamamoto, Keita, Fujino, Takeshi, Wang, Teh-Wei, Sugimoto, Emi, Zhang, Wenyu, Yabushita, Tomohiro, Suzaki, Ken, Pietsch, E. Christine, Weir, Barbara A., Crescenzo, Ramona, Cowley, Glenn S., Attar, Ricardo, Philippar, Ulrike, Wunderlich, Mark, Mizukawa, Benjamin, Zheng, Yi, Enomoto, Yutaka, Imai, Yoichi, Kitamura, Toshio, and Goyama, Susumu

Published
2024
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5. Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion

Author

Stalmann, Ursula S.A., Ticconi, Fabio, Snoeren, Inge A.M., Li, Ronghui, Gleitz, Hélène F.E., Cowley, Glenn S., McConkey, Marie E., Wong, Aaron B., Schmitz, Stephani, Fuchs, Stijn N.R., Sood, Shubhankar, Leimkühler, Nils B., Martinez-Høyer, Sergio, Banjanin, Bella, Root, David, Brümmendorf, Tim H., Pearce, Juliette E., Schuppert, Andreas, Bindels, Eric M.J., Essers, Marieke A., Heckl, Dirk, Stiehl, Thomas, Costa, Ivan G., Ebert, Benjamin L., and Schneider, Rebekka K.

Published
2022
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6. CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2

Author

Chen, Liying, Alexe, Gabriela, Dharia, Neekesh V, Ross, Linda, Iniguez, Amanda Balboni, Conway, Amy Saur, Wang, Emily Jue, Veschi, Veronica, Lam, Norris, Qi, Jun, Gustafson, W Clay, Nasholm, Nicole, Vazquez, Francisca, Weir, Barbara A, Cowley, Glenn S, Ali, Levi D, Pantel, Sasha, Jiang, Guozhi, Harrington, William F, Lee, Yenarae, Goodale, Amy, Lubonja, Rakela, Krill-Burger, John M, Meyers, Robin M, Tsherniak, Aviad, Root, David E, Bradner, James E, Golub, Todd R, Roberts, Charles WM, Hahn, William C, Weiss, William A, Thiele, Carol J, and Stegmaier, Kimberly

Subjects
Neuroblastoma, Rare Diseases, Human Genome, Cancer, Pediatric Cancer, Pediatric Research Initiative, Neurosciences, Pediatric, Genetics, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, CRISPR-Cas Systems, Cell Differentiation, Cell Line, Tumor, Enhancer of Zeste Homolog 2 Protein, Gene Amplification, Gene Expression Regulation, Neoplastic, Humans, N-Myc Proto-Oncogene Protein, Neurons, Up-Regulation, Epigenetics, Oncology, Medical and Health Sciences, Immunology
Abstract

Pharmacologically difficult targets, such as MYC transcription factors, represent a major challenge in cancer therapy. For the childhood cancer neuroblastoma, amplification of the oncogene MYCN is associated with high-risk disease and poor prognosis. Here, we deployed genome-scale CRISPR-Cas9 screening of MYCN-amplified neuroblastoma and found a preferential dependency on genes encoding the polycomb repressive complex 2 (PRC2) components EZH2, EED, and SUZ12. Genetic and pharmacological suppression of EZH2 inhibited neuroblastoma growth in vitro and in vivo. Moreover, compared with neuroblastomas without MYCN amplification, MYCN-amplified neuroblastomas expressed higher levels of EZH2. ChIP analysis showed that MYCN binds at the EZH2 promoter, thereby directly driving expression. Transcriptomic and epigenetic analysis, as well as genetic rescue experiments, revealed that EZH2 represses neuronal differentiation in neuroblastoma in a PRC2-dependent manner. Moreover, MYCN-amplified and high-risk primary tumors from patients with neuroblastoma exhibited strong repression of EZH2-regulated genes. Additionally, overexpression of IGFBP3, a direct EZH2 target, suppressed neuroblastoma growth in vitro and in vivo. We further observed strong synergy between histone deacetylase inhibitors and EZH2 inhibitors. Together, these observations demonstrate that MYCN upregulates EZH2, leading to inactivation of a tumor suppressor program in neuroblastoma, and support testing EZH2 inhibitors in patients with MYCN-amplified neuroblastoma.

Published
2018

7. A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

Author

Gönen, Mehmet, Weir, Barbara A, Cowley, Glenn S, Vazquez, Francisca, Guan, Yuanfang, Jaiswal, Alok, Karasuyama, Masayuki, Uzunangelov, Vladislav, Wang, Tao, Tsherniak, Aviad, Howell, Sara, Marbach, Daniel, Hoff, Bruce, Norman, Thea C, Airola, Antti, Bivol, Adrian, Bunte, Kerstin, Carlin, Daniel, Chopra, Sahil, Deran, Alden, Ellrott, Kyle, Gopalacharyulu, Peddinti, Graim, Kiley, Kaski, Samuel, Khan, Suleiman A, Newton, Yulia, Ng, Sam, Pahikkala, Tapio, Paull, Evan, Sokolov, Artem, Tang, Hao, Tang, Jing, Wennerberg, Krister, Xie, Yang, Zhan, Xiaowei, Zhu, Fan, Community, Broad-DREAM, Afsari, Bahman, Aittokallio, Tero, Boehm, Jesse S, Chang, Yu-Chuan, Chen, Tenghui, Chong, Zechen, Elmarakeby, Haitham, Fertig, Elana J, Gonçalves, Emanuel, Gong, Pinghua, Hafemeister, Christoph, Hahn, William C, Heath, Lenwood, Kędziorski, Łukasz, Khemka, Niraj, King, Erh-kan, Lauria, Mario, Liu, Mark, Machado, Daniel, Mamitsuka, Hiroshi, Margolin, Adam A, Mazurkiewicz, Mateusz, Menden, Michael P, Migacz, Szymon, Nie, Zhi, Praveen, Paurush, Priami, Corrado, Rizzetto, Simone, Rocha, Miguel, Root, David E, Rudd, Cameron, Rudnicki, Witold R, Saez-Rodriguez, Julio, Song, Lei, Stolovitzky, Gustavo, Stuart, Joshua M, Sun, Duanchen, and Szalai, Bence

Subjects
Biological Sciences, Genetics, Biotechnology, Prevention, Cancer, Human Genome, Algorithms, Cell Line, Tumor, Gene Expression, Genes, Essential, Genomics, Humans, RNA, Small Interfering, Broad-DREAM Community, cancer genomics, community challenge, crowdsourcing, functional screen, machine learning, oncogene, Biochemistry and Cell Biology, Biochemistry and cell biology
Abstract

We report the results of a DREAM challenge designed to predict relative genetic essentialities based on a novel dataset testing 98,000 shRNAs against 149 molecularly characterized cancer cell lines. We analyzed the results of over 3,000 submissions over a period of 4 months. We found that algorithms combining essentiality data across multiple genes demonstrated increased accuracy; gene expression was the most informative molecular data type; the identity of the gene being predicted was far more important than the modeling strategy; well-predicted genes and selected molecular features showed enrichment in functional categories; and frequently selected expression features correlated with survival in primary tumors. This study establishes benchmarks for gene essentiality prediction, presents a community resource for future comparison with this benchmark, and provides insights into factors influencing the ability to predict gene essentiality from functional genetic screens. This study also demonstrates the value of releasing pre-publication data publicly to engage the community in an open research collaboration.

Published
2017

8. Supplementary Table S2 from Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma

Author

Marino-Enriquez, Adrian, primary, Novotny, Jan Philipp, primary, Gulhan, Doga C., primary, Klooster, Isabella, primary, Tran, Antuan V., primary, Kasbo, Macy, primary, Lundberg, Meijun Z., primary, Ou, Wen-Bin, primary, Tao, Derrick L., primary, Pilco-Janeta, Daniel F., primary, Mao, Victor Y., primary, Zenke, Frank T., primary, Leeper, Brittaney A., primary, Gokhale, Prafulla C., primary, Cowley, Glenn S., primary, Baker, Laurence H., primary, Ballman, Karla V., primary, Root, David E., primary, Albers, Joachim, primary, Park, Peter J., primary, George, Suzanne, primary, and Fletcher, Jonathan A., primary

Published
2023
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9. Supplementary Figure S7 from Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma

Author

Marino-Enriquez, Adrian, primary, Novotny, Jan Philipp, primary, Gulhan, Doga C., primary, Klooster, Isabella, primary, Tran, Antuan V., primary, Kasbo, Macy, primary, Lundberg, Meijun Z., primary, Ou, Wen-Bin, primary, Tao, Derrick L., primary, Pilco-Janeta, Daniel F., primary, Mao, Victor Y., primary, Zenke, Frank T., primary, Leeper, Brittaney A., primary, Gokhale, Prafulla C., primary, Cowley, Glenn S., primary, Baker, Laurence H., primary, Ballman, Karla V., primary, Root, David E., primary, Albers, Joachim, primary, Park, Peter J., primary, George, Suzanne, primary, and Fletcher, Jonathan A., primary

Published
2023
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10. Erratum: Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Author

Cowley, Glenn S, Weir, Barbara A, Vazquez, Francisca, Tamayo, Pablo, Scott, Justine A, Rusin, Scott, East-Seletsky, Alexandra, Ali, Levi D, Gerath, William FJ, Pantel, Sarah E, Lizotte, Patrick H, Jiang, Guozhi, Hsiao, Jessica, Tsherniak, Aviad, Dwinell, Elizabeth, Aoyama, Simon, Okamoto, Michael, Harrington, William, Gelfand, Ellen, Green, Thomas M, Tomko, Mark J, Gopal, Shuba, Wong, Terence C, Li, Hubo, Howell, Sara, Stransky, Nicolas, Liefeld, Ted, Jang, Dongkeun, Bistline, Jonathan, Meyers, Barbara Hill, Armstrong, Scott A, Anderson, Ken C, Stegmaier, Kimberly, Reich, Michael, Pellman, David, Boehm, Jesse S, Mesirov, Jill P, Golub, Todd R, Root, David E, and Hahn, William C

Subjects
Biological Sciences, Genetics, Cancer, Bioinformatics and Computational Biology, Biotechnology, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Cell Line, Tumor, Cell Lineage, Cell Proliferation, DNA, Neoplasm, Gene Expression Regulation, Neoplastic, Genomics, Humans, Mutation, Neoplasms, RNA, Small Interfering
Abstract

Using a genome-scale, lentivirally delivered shRNA library, we performed massively parallel pooled shRNA screens in 216 cancer cell lines to identify genes that are required for cell proliferation and/or viability. Cell line dependencies on 11,000 genes were interrogated by 5 shRNAs per gene. The proliferation effect of each shRNA in each cell line was assessed by transducing a population of 11M cells with one shRNA-virus per cell and determining the relative enrichment or depletion of each of the 54,000 shRNAs after 16 population doublings using Next Generation Sequencing. All the cell lines were screened using standardized conditions to best assess differential genetic dependencies across cell lines. When combined with genomic characterization of these cell lines, this dataset facilitates the linkage of genetic dependencies with specific cellular contexts (e.g., gene mutations or cell lineage). To enable such comparisons, we developed and provided a bioinformatics tool to identify linear and nonlinear correlations between these features.

Published
2014

11. Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Author

Cowley, Glenn S, Weir, Barbara A, Vazquez, Francisca, Tamayo, Pablo, Scott, Justine A, Rusin, Scott, East-Seletsky, Alexandra, Ali, Levi D, Gerath, William Fj, Pantel, Sarah E, Lizotte, Patrick H, Jiang, Guozhi, Hsiao, Jessica, Tsherniak, Aviad, Dwinell, Elizabeth, Aoyama, Simon, Okamoto, Michael, Harrington, William, Gelfand, Ellen, Green, Thomas M, Tomko, Mark J, Gopal, Shuba, Wong, Terence C, Li, Hubo, Howell, Sara, Stransky, Nicolas, Liefeld, Ted, Jang, Dongkeun, Bistline, Jonathan, Hill Meyers, Barbara, Armstrong, Scott A, Anderson, Ken C, Stegmaier, Kimberly, Reich, Michael, Pellman, David, Boehm, Jesse S, Mesirov, Jill P, Golub, Todd R, Root, David E, and Hahn, William C

Subjects
Cell Line, Tumor, Humans, Neoplasms, RNA, Small Interfering, DNA, Neoplasm, Genomics, Cell Proliferation, Gene Expression Regulation, Neoplastic, Cell Lineage, Mutation, Biotechnology, Genetics, Cancer, Human Genome, 2.1 Biological and endogenous factors
Abstract

Using a genome-scale, lentivirally delivered shRNA library, we performed massively parallel pooled shRNA screens in 216 cancer cell lines to identify genes that are required for cell proliferation and/or viability. Cell line dependencies on 11,000 genes were interrogated by 5 shRNAs per gene. The proliferation effect of each shRNA in each cell line was assessed by transducing a population of 11M cells with one shRNA-virus per cell and determining the relative enrichment or depletion of each of the 54,000 shRNAs after 16 population doublings using Next Generation Sequencing. All the cell lines were screened using standardized conditions to best assess differential genetic dependencies across cell lines. When combined with genomic characterization of these cell lines, this dataset facilitates the linkage of genetic dependencies with specific cellular contexts (e.g., gene mutations or cell lineage). To enable such comparisons, we developed and provided a bioinformatics tool to identify linear and nonlinear correlations between these features.

Published
2014

12. Hyper-Dependence on NHEJ Enables Synergy Between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma

Author

Mariño-Enríquez, Adrián, primary, Novotny, Jan Philipp, additional, Gulhan, Doga C., additional, Klooster, Isabella, additional, Tran, Antuan V., additional, Kasbo, Macy, additional, Lundberg, Meijun Z., additional, Ou, Wen-Bin, additional, Tao, Derrick L., additional, Pilco-Janeta, Daniel F., additional, Mao, Victor Y., additional, Zenke, Frank T., additional, Leeper, Brittaney A., additional, Gokhale, Prafulla C., additional, Cowley, Glenn S., additional, Baker, Laurence H., additional, Ballman, Karla V., additional, Root, David E., additional, Albers, Joachim, additional, Park, Peter J., additional, George, Suzanne, additional, and Fletcher, Jonathan A., additional

Published
2023
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13. REPLY TO HAFFNER ET AL. : DNA hypomethylation renders tumors more immunogenic

Author

Stone, Meredith L., Chiappinelli, Katherine B., Li, Huili, Murphy, Lauren M., Travers, Meghan E., Topper, Michael J., Mathios, Dimitrios, Lim, Michael, Shih, Ie-Ming, Wang, Tian-Li, Hung, Chien-Fu, Bhargava, Vipul, Wiehagen, Karla R., Cowley, Glenn S., Bachman, Kurtis E., Strick, Reiner, Strissel, Pamela L., Baylin, Stephen B., and Zahnow, Cynthia A.

Published
2018

14. Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden

Author

Stone, Meredith L., Chiappinelli, Katherine B., Li, Huili, Murphy, Lauren M., Travers, Meghan E., Topper, Michael J., Mathios, Dimitrios, Lim, Michael, Shih, Ie-Ming, Wang, Tian-Li, Hung, Chien-Fu, Bhargava, Vipul, Wiehagen, Karla R., Cowley, Glenn S., Bachman, Kurtis E., Strick, Reiner, Strissel, Pamela L., Baylin, Stephen B., and Zahnow, Cynthia A.

Published
2017

16. Small-molecule targeting of brachyury transcription factor addiction in chordoma

Author

Sharifnia, Tanaz, Wawer, Mathias J., Chen, Ting, Huang, Qing-Yuan, Weir, Barbara A., Sizemore, Ann, Lawlor, Matthew A., Goodale, Amy, Cowley, Glenn S., Vazquez, Francisca, Ott, Christopher J., Francis, Joshua M., Sassi, Slim, Cogswell, Patricia, Sheppard, Hadley E., Zhang, Tinghu, Gray, Nathanael S., Clarke, Paul A., Blagg, Julian, Workman, Paul, Sommer, Josh, Hornicek, Francis, Root, David E., Hahn, William C., Bradner, James E., Wong, Kwok K., Clemons, Paul A., Lin, Charles Y., Kotz, Joanne D., and Schreiber, Stuart L.

Published
2019
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17. PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

Author

Ilic, Nina, Birsoy, Kıvanç, Aguirre, Andrew J., Kory, Nora, Pacold, Michael E., Singh, Shambhavi, Moody, Susan E., DeAngelo, Joseph D., Spardy, Nicole A., Freinkman, Elizaveta, Weir, Barbara A., Tsherniak, Aviad, Cowley, Glenn S., Root, David E., Asara, John M., Vazquez, Francisca, Widlund, Hans R., Sabatini, David M., and Hahn, William C.

Published
2017

18. A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

Author

Eller, Carla, Heydmann, Laura, Colpitts, Che C., El Saghire, Houssein, Piccioni, Federica, Jühling, Frank, Majzoub, Karim, Pons, Caroline, Bach, Charlotte, Lucifora, Julie, Lupberger, Joachim, Nassal, Michael, Cowley, Glenn S., Fujiwara, Naoto, Hsieh, Sen-Yung, Hoshida, Yujin, Felli, Emanuele, Pessaux, Patrick, Sureau, Camille, Schuster, Catherine, Root, David E., Verrier, Eloi R., and Baumert, Thomas F.

Published
2020
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19. Supplementary Table S1.4 from Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer

Author

Liu, Yan, primary, Marks, Kevin, primary, Cowley, Glenn S., primary, Carretero, Julian, primary, Liu, Qingsong, primary, Nieland, Thomas J.F., primary, Xu, Chunxiao, primary, Cohoon, Travis J., primary, Gao, Peng, primary, Zhang, Yong, primary, Chen, Zhao, primary, Altabef, Abigail B., primary, Tchaicha, Jeremy H., primary, Wang, Xiaoxu, primary, Choe, Sung, primary, Driggers, Edward M., primary, Zhang, Jianming, primary, Bailey, Sean T., primary, Sharpless, Norman E., primary, Hayes, D. Neil, primary, Patel, Nirali M., primary, Janne, Pasi A., primary, Bardeesy, Nabeel, primary, Engelman, Jeffrey A., primary, Manning, Brendan D., primary, Shaw, Reuben J., primary, Asara, John M., primary, Scully, Ralph, primary, Kimmelman, Alec, primary, Byers, Lauren A., primary, Gibbons, Don L., primary, Wistuba, Ignacio I., primary, Heymach, John V., primary, Kwiatkowski, David J., primary, Kim, William Y., primary, Kung, Andrew L., primary, Gray, Nathanael S., primary, Root, David E., primary, Cantley, Lewis C., primary, and Wong, Kwok-Kin, primary

Published
2023
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21. Supplementary Table S5 from Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival

Author

Oser, Matthew G., primary, Fonseca, Raquel, primary, Chakraborty, Abhishek A., primary, Brough, Rachel, primary, Spektor, Alexander, primary, Jennings, Rebecca B., primary, Flaifel, Abdallah, primary, Novak, Jesse S., primary, Gulati, Aditi, primary, Buss, Elizabeth, primary, Younger, Scott T., primary, McBrayer, Samuel K., primary, Cowley, Glenn S., primary, Bonal, Dennis M., primary, Nguyen, Quang-De, primary, Brulle-Soumare, Laura, primary, Taylor, Paula, primary, Cairo, Stefano, primary, Ryan, Colm J., primary, Pease, Elizabeth J., primary, Maratea, Kim, primary, Travers, Jon, primary, Root, David E., primary, Signoretti, Sabina, primary, Pellman, David, primary, Ashton, Susan, primary, Lord, Christopher J., primary, Barry, Simon T., primary, and Kaelin, William G., primary

Published
2023
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22. Supplementary Figures S6 - S10 from Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Author

Aguirre, Andrew J., primary, Meyers, Robin M., primary, Weir, Barbara A., primary, Vazquez, Francisca, primary, Zhang, Cheng-Zhong, primary, Ben-David, Uri, primary, Cook, April, primary, Ha, Gavin, primary, Harrington, William F., primary, Doshi, Mihir B., primary, Kost-Alimova, Maria, primary, Gill, Stanley, primary, Xu, Han, primary, Ali, Levi D., primary, Jiang, Guozhi, primary, Pantel, Sasha, primary, Lee, Yenarae, primary, Goodale, Amy, primary, Cherniack, Andrew D., primary, Oh, Coyin, primary, Kryukov, Gregory, primary, Cowley, Glenn S., primary, Garraway, Levi A., primary, Stegmaier, Kimberly, primary, Roberts, Charles W., primary, Golub, Todd R., primary, Meyerson, Matthew, primary, Root, David E., primary, Tsherniak, Aviad, primary, and Hahn, William C., primary

Published
2023
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25. Supplementary Table S1 from Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Author

Aguirre, Andrew J., primary, Meyers, Robin M., primary, Weir, Barbara A., primary, Vazquez, Francisca, primary, Zhang, Cheng-Zhong, primary, Ben-David, Uri, primary, Cook, April, primary, Ha, Gavin, primary, Harrington, William F., primary, Doshi, Mihir B., primary, Kost-Alimova, Maria, primary, Gill, Stanley, primary, Xu, Han, primary, Ali, Levi D., primary, Jiang, Guozhi, primary, Pantel, Sasha, primary, Lee, Yenarae, primary, Goodale, Amy, primary, Cherniack, Andrew D., primary, Oh, Coyin, primary, Kryukov, Gregory, primary, Cowley, Glenn S., primary, Garraway, Levi A., primary, Stegmaier, Kimberly, primary, Roberts, Charles W., primary, Golub, Todd R., primary, Meyerson, Matthew, primary, Root, David E., primary, Tsherniak, Aviad, primary, and Hahn, William C., primary

Published
2023
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26. Data from Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer

Author

Liu, Yan, primary, Marks, Kevin, primary, Cowley, Glenn S., primary, Carretero, Julian, primary, Liu, Qingsong, primary, Nieland, Thomas J.F., primary, Xu, Chunxiao, primary, Cohoon, Travis J., primary, Gao, Peng, primary, Zhang, Yong, primary, Chen, Zhao, primary, Altabef, Abigail B., primary, Tchaicha, Jeremy H., primary, Wang, Xiaoxu, primary, Choe, Sung, primary, Driggers, Edward M., primary, Zhang, Jianming, primary, Bailey, Sean T., primary, Sharpless, Norman E., primary, Hayes, D. Neil, primary, Patel, Nirali M., primary, Janne, Pasi A., primary, Bardeesy, Nabeel, primary, Engelman, Jeffrey A., primary, Manning, Brendan D., primary, Shaw, Reuben J., primary, Asara, John M., primary, Scully, Ralph, primary, Kimmelman, Alec, primary, Byers, Lauren A., primary, Gibbons, Don L., primary, Wistuba, Ignacio I., primary, Heymach, John V., primary, Kwiatkowski, David J., primary, Kim, William Y., primary, Kung, Andrew L., primary, Gray, Nathanael S., primary, Root, David E., primary, Cantley, Lewis C., primary, and Wong, Kwok-Kin, primary

Published
2023
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27. Supplementary Figures S1- S10 from Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer

Author

Liu, Yan, primary, Marks, Kevin, primary, Cowley, Glenn S., primary, Carretero, Julian, primary, Liu, Qingsong, primary, Nieland, Thomas J.F., primary, Xu, Chunxiao, primary, Cohoon, Travis J., primary, Gao, Peng, primary, Zhang, Yong, primary, Chen, Zhao, primary, Altabef, Abigail B., primary, Tchaicha, Jeremy H., primary, Wang, Xiaoxu, primary, Choe, Sung, primary, Driggers, Edward M., primary, Zhang, Jianming, primary, Bailey, Sean T., primary, Sharpless, Norman E., primary, Hayes, D. Neil, primary, Patel, Nirali M., primary, Janne, Pasi A., primary, Bardeesy, Nabeel, primary, Engelman, Jeffrey A., primary, Manning, Brendan D., primary, Shaw, Reuben J., primary, Asara, John M., primary, Scully, Ralph, primary, Kimmelman, Alec, primary, Byers, Lauren A., primary, Gibbons, Don L., primary, Wistuba, Ignacio I., primary, Heymach, John V., primary, Kwiatkowski, David J., primary, Kim, William Y., primary, Kung, Andrew L., primary, Gray, Nathanael S., primary, Root, David E., primary, Cantley, Lewis C., primary, and Wong, Kwok-Kin, primary

Published
2023
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28. Supplementary Figure Legends from Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Author

Aguirre, Andrew J., primary, Meyers, Robin M., primary, Weir, Barbara A., primary, Vazquez, Francisca, primary, Zhang, Cheng-Zhong, primary, Ben-David, Uri, primary, Cook, April, primary, Ha, Gavin, primary, Harrington, William F., primary, Doshi, Mihir B., primary, Kost-Alimova, Maria, primary, Gill, Stanley, primary, Xu, Han, primary, Ali, Levi D., primary, Jiang, Guozhi, primary, Pantel, Sasha, primary, Lee, Yenarae, primary, Goodale, Amy, primary, Cherniack, Andrew D., primary, Oh, Coyin, primary, Kryukov, Gregory, primary, Cowley, Glenn S., primary, Garraway, Levi A., primary, Stegmaier, Kimberly, primary, Roberts, Charles W., primary, Golub, Todd R., primary, Meyerson, Matthew, primary, Root, David E., primary, Tsherniak, Aviad, primary, and Hahn, William C., primary

Published
2023
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29. Data from Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival

Author

Oser, Matthew G., primary, Fonseca, Raquel, primary, Chakraborty, Abhishek A., primary, Brough, Rachel, primary, Spektor, Alexander, primary, Jennings, Rebecca B., primary, Flaifel, Abdallah, primary, Novak, Jesse S., primary, Gulati, Aditi, primary, Buss, Elizabeth, primary, Younger, Scott T., primary, McBrayer, Samuel K., primary, Cowley, Glenn S., primary, Bonal, Dennis M., primary, Nguyen, Quang-De, primary, Brulle-Soumare, Laura, primary, Taylor, Paula, primary, Cairo, Stefano, primary, Ryan, Colm J., primary, Pease, Elizabeth J., primary, Maratea, Kim, primary, Travers, Jon, primary, Root, David E., primary, Signoretti, Sabina, primary, Pellman, David, primary, Ashton, Susan, primary, Lord, Christopher J., primary, Barry, Simon T., primary, and Kaelin, William G., primary

Published
2023
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30. Supplementary Figures S1-S10 from Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival

Author

Oser, Matthew G., primary, Fonseca, Raquel, primary, Chakraborty, Abhishek A., primary, Brough, Rachel, primary, Spektor, Alexander, primary, Jennings, Rebecca B., primary, Flaifel, Abdallah, primary, Novak, Jesse S., primary, Gulati, Aditi, primary, Buss, Elizabeth, primary, Younger, Scott T., primary, McBrayer, Samuel K., primary, Cowley, Glenn S., primary, Bonal, Dennis M., primary, Nguyen, Quang-De, primary, Brulle-Soumare, Laura, primary, Taylor, Paula, primary, Cairo, Stefano, primary, Ryan, Colm J., primary, Pease, Elizabeth J., primary, Maratea, Kim, primary, Travers, Jon, primary, Root, David E., primary, Signoretti, Sabina, primary, Pellman, David, primary, Ashton, Susan, primary, Lord, Christopher J., primary, Barry, Simon T., primary, and Kaelin, William G., primary

Published
2023
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33. Data from Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Author

Aguirre, Andrew J., primary, Meyers, Robin M., primary, Weir, Barbara A., primary, Vazquez, Francisca, primary, Zhang, Cheng-Zhong, primary, Ben-David, Uri, primary, Cook, April, primary, Ha, Gavin, primary, Harrington, William F., primary, Doshi, Mihir B., primary, Kost-Alimova, Maria, primary, Gill, Stanley, primary, Xu, Han, primary, Ali, Levi D., primary, Jiang, Guozhi, primary, Pantel, Sasha, primary, Lee, Yenarae, primary, Goodale, Amy, primary, Cherniack, Andrew D., primary, Oh, Coyin, primary, Kryukov, Gregory, primary, Cowley, Glenn S., primary, Garraway, Levi A., primary, Stegmaier, Kimberly, primary, Roberts, Charles W., primary, Golub, Todd R., primary, Meyerson, Matthew, primary, Root, David E., primary, Tsherniak, Aviad, primary, and Hahn, William C., primary

Published
2023
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37. Text for Supplementary Data from Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival

Author

Oser, Matthew G., primary, Fonseca, Raquel, primary, Chakraborty, Abhishek A., primary, Brough, Rachel, primary, Spektor, Alexander, primary, Jennings, Rebecca B., primary, Flaifel, Abdallah, primary, Novak, Jesse S., primary, Gulati, Aditi, primary, Buss, Elizabeth, primary, Younger, Scott T., primary, McBrayer, Samuel K., primary, Cowley, Glenn S., primary, Bonal, Dennis M., primary, Nguyen, Quang-De, primary, Brulle-Soumare, Laura, primary, Taylor, Paula, primary, Cairo, Stefano, primary, Ryan, Colm J., primary, Pease, Elizabeth J., primary, Maratea, Kim, primary, Travers, Jon, primary, Root, David E., primary, Signoretti, Sabina, primary, Pellman, David, primary, Ashton, Susan, primary, Lord, Christopher J., primary, Barry, Simon T., primary, and Kaelin, William G., primary

Published
2023
Full Text
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38. Supplementary Methods from Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Author

Aguirre, Andrew J., primary, Meyers, Robin M., primary, Weir, Barbara A., primary, Vazquez, Francisca, primary, Zhang, Cheng-Zhong, primary, Ben-David, Uri, primary, Cook, April, primary, Ha, Gavin, primary, Harrington, William F., primary, Doshi, Mihir B., primary, Kost-Alimova, Maria, primary, Gill, Stanley, primary, Xu, Han, primary, Ali, Levi D., primary, Jiang, Guozhi, primary, Pantel, Sasha, primary, Lee, Yenarae, primary, Goodale, Amy, primary, Cherniack, Andrew D., primary, Oh, Coyin, primary, Kryukov, Gregory, primary, Cowley, Glenn S., primary, Garraway, Levi A., primary, Stegmaier, Kimberly, primary, Roberts, Charles W., primary, Golub, Todd R., primary, Meyerson, Matthew, primary, Root, David E., primary, Tsherniak, Aviad, primary, and Hahn, William C., primary

Published
2023
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39. Supplementary Methods, Figure Legends from Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer

Author

Liu, Yan, primary, Marks, Kevin, primary, Cowley, Glenn S., primary, Carretero, Julian, primary, Liu, Qingsong, primary, Nieland, Thomas J.F., primary, Xu, Chunxiao, primary, Cohoon, Travis J., primary, Gao, Peng, primary, Zhang, Yong, primary, Chen, Zhao, primary, Altabef, Abigail B., primary, Tchaicha, Jeremy H., primary, Wang, Xiaoxu, primary, Choe, Sung, primary, Driggers, Edward M., primary, Zhang, Jianming, primary, Bailey, Sean T., primary, Sharpless, Norman E., primary, Hayes, D. Neil, primary, Patel, Nirali M., primary, Janne, Pasi A., primary, Bardeesy, Nabeel, primary, Engelman, Jeffrey A., primary, Manning, Brendan D., primary, Shaw, Reuben J., primary, Asara, John M., primary, Scully, Ralph, primary, Kimmelman, Alec, primary, Byers, Lauren A., primary, Gibbons, Don L., primary, Wistuba, Ignacio I., primary, Heymach, John V., primary, Kwiatkowski, David J., primary, Kim, William Y., primary, Kung, Andrew L., primary, Gray, Nathanael S., primary, Root, David E., primary, Cantley, Lewis C., primary, and Wong, Kwok-Kin, primary

Published
2023
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41. Supplementary Table 4 from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer

Author

Hsu, Jessie Hao-Ru, primary, Hubbell-Engler, Benjamin, primary, Adelmant, Guillaume, primary, Huang, Jialiang, primary, Joyce, Cailin E., primary, Vazquez, Francisca, primary, Weir, Barbara A., primary, Montgomery, Philip, primary, Tsherniak, Aviad, primary, Giacomelli, Andrew O., primary, Perry, Jennifer A., primary, Trowbridge, Jennifer, primary, Fujiwara, Yuko, primary, Cowley, Glenn S., primary, Xie, Huafeng, primary, Kim, Woojin, primary, Novina, Carl D., primary, Hahn, William C., primary, Marto, Jarrod A., primary, and Orkin, Stuart H., primary

Published
2023
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42. Supplementary Table 2 from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer

Author

Hsu, Jessie Hao-Ru, primary, Hubbell-Engler, Benjamin, primary, Adelmant, Guillaume, primary, Huang, Jialiang, primary, Joyce, Cailin E., primary, Vazquez, Francisca, primary, Weir, Barbara A., primary, Montgomery, Philip, primary, Tsherniak, Aviad, primary, Giacomelli, Andrew O., primary, Perry, Jennifer A., primary, Trowbridge, Jennifer, primary, Fujiwara, Yuko, primary, Cowley, Glenn S., primary, Xie, Huafeng, primary, Kim, Woojin, primary, Novina, Carl D., primary, Hahn, William C., primary, Marto, Jarrod A., primary, and Orkin, Stuart H., primary

Published
2023
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43. Supplementary Table 1 from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer

Author

Hsu, Jessie Hao-Ru, primary, Hubbell-Engler, Benjamin, primary, Adelmant, Guillaume, primary, Huang, Jialiang, primary, Joyce, Cailin E., primary, Vazquez, Francisca, primary, Weir, Barbara A., primary, Montgomery, Philip, primary, Tsherniak, Aviad, primary, Giacomelli, Andrew O., primary, Perry, Jennifer A., primary, Trowbridge, Jennifer, primary, Fujiwara, Yuko, primary, Cowley, Glenn S., primary, Xie, Huafeng, primary, Kim, Woojin, primary, Novina, Carl D., primary, Hahn, William C., primary, Marto, Jarrod A., primary, and Orkin, Stuart H., primary

Published
2023
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44. Supplementary Table 5 from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer

Author

Hsu, Jessie Hao-Ru, primary, Hubbell-Engler, Benjamin, primary, Adelmant, Guillaume, primary, Huang, Jialiang, primary, Joyce, Cailin E., primary, Vazquez, Francisca, primary, Weir, Barbara A., primary, Montgomery, Philip, primary, Tsherniak, Aviad, primary, Giacomelli, Andrew O., primary, Perry, Jennifer A., primary, Trowbridge, Jennifer, primary, Fujiwara, Yuko, primary, Cowley, Glenn S., primary, Xie, Huafeng, primary, Kim, Woojin, primary, Novina, Carl D., primary, Hahn, William C., primary, Marto, Jarrod A., primary, and Orkin, Stuart H., primary

Published
2023
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45. Supplementary method from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer

Author

Hsu, Jessie Hao-Ru, primary, Hubbell-Engler, Benjamin, primary, Adelmant, Guillaume, primary, Huang, Jialiang, primary, Joyce, Cailin E., primary, Vazquez, Francisca, primary, Weir, Barbara A., primary, Montgomery, Philip, primary, Tsherniak, Aviad, primary, Giacomelli, Andrew O., primary, Perry, Jennifer A., primary, Trowbridge, Jennifer, primary, Fujiwara, Yuko, primary, Cowley, Glenn S., primary, Xie, Huafeng, primary, Kim, Woojin, primary, Novina, Carl D., primary, Hahn, William C., primary, Marto, Jarrod A., primary, and Orkin, Stuart H., primary

Published
2023
Full Text
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46. Data from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer

Author

Hsu, Jessie Hao-Ru, primary, Hubbell-Engler, Benjamin, primary, Adelmant, Guillaume, primary, Huang, Jialiang, primary, Joyce, Cailin E., primary, Vazquez, Francisca, primary, Weir, Barbara A., primary, Montgomery, Philip, primary, Tsherniak, Aviad, primary, Giacomelli, Andrew O., primary, Perry, Jennifer A., primary, Trowbridge, Jennifer, primary, Fujiwara, Yuko, primary, Cowley, Glenn S., primary, Xie, Huafeng, primary, Kim, Woojin, primary, Novina, Carl D., primary, Hahn, William C., primary, Marto, Jarrod A., primary, and Orkin, Stuart H., primary

Published
2023
Full Text
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47. Supplementary Figures and Legends from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer

Author

Hsu, Jessie Hao-Ru, primary, Hubbell-Engler, Benjamin, primary, Adelmant, Guillaume, primary, Huang, Jialiang, primary, Joyce, Cailin E., primary, Vazquez, Francisca, primary, Weir, Barbara A., primary, Montgomery, Philip, primary, Tsherniak, Aviad, primary, Giacomelli, Andrew O., primary, Perry, Jennifer A., primary, Trowbridge, Jennifer, primary, Fujiwara, Yuko, primary, Cowley, Glenn S., primary, Xie, Huafeng, primary, Kim, Woojin, primary, Novina, Carl D., primary, Hahn, William C., primary, Marto, Jarrod A., primary, and Orkin, Stuart H., primary

Published
2023
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48. Supplementary Table 3 from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer

Author

Hsu, Jessie Hao-Ru, primary, Hubbell-Engler, Benjamin, primary, Adelmant, Guillaume, primary, Huang, Jialiang, primary, Joyce, Cailin E., primary, Vazquez, Francisca, primary, Weir, Barbara A., primary, Montgomery, Philip, primary, Tsherniak, Aviad, primary, Giacomelli, Andrew O., primary, Perry, Jennifer A., primary, Trowbridge, Jennifer, primary, Fujiwara, Yuko, primary, Cowley, Glenn S., primary, Xie, Huafeng, primary, Kim, Woojin, primary, Novina, Carl D., primary, Hahn, William C., primary, Marto, Jarrod A., primary, and Orkin, Stuart H., primary

Published
2023
Full Text
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50. MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

Author

Kryukov, Gregory V., Wilson, Frederick H., Ruth, Jason R., Paulk, Joshiawa, Tsherniak, Aviad, Marlow, Sara E., Vazquez, Francisca, Weir, Barbara A., Fitzgerald, Mark E., Tanaka, Minoru, Bielski, Craig M., Scott, Justin M., Dennis, Courtney, Cowley, Glenn S., Boehm, Jesse S., Root, David E., Golub, Todd R., Clish, Clary B., Bradner, James E., Hahn, William C., and Garraway, Levi A.

Published
2016

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