Search

Your search keyword '"Coward, J."' showing total 407 results
Start Over Author "Coward, J."
407 results on '"Coward, J."'

1. Copy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci

Author

DeVries, Amber A, Dennis, Joe, Tyrer, Jonathan P, Peng, Pei-Chen, Coetzee, Simon G, Reyes, Alberto L, Plummer, Jasmine T, Davis, Brian D, Chen, Stephanie S, Dezem, Felipe Segato, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia N, Beckmann, Matthias W, Beeghly-Fadiel, Alicia, Berchuck, Andrew, Bogdanova, Natalia V, Bogdanova-Markov, Nadja, Brenton, James D, Butzow, Ralf, Campbell, Ian, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Cook, Linda S, DeFazio, Anna, Doherty, Jennifer A, Dörk, Thilo, Eccles, Diana M, Eliassen, A Heather, Fasching, Peter A, Fortner, Renée T, Giles, Graham G, Goode, Ellen L, Goodman, Marc T, Gronwald, Jacek, Webb, P, DeFazio, A, Friedlander, M, Obermair, A, Grant, P, Nagle, C, Beesley, V, Chevenix-Trench, G, Bowtell, D, Blomfield, P, Brand, A, Davis, A, Leung, Y, Nicklin, J, Quinn, M, Livingstone, K, O'Neill, H, Williams, M, Black, A, Hadley, A, Glasgow, A, Garrett, A, Rao, A, Shannon, C, Steer, C, Allen, D, Neesham, D, Otton, G, Au-Yeung, G, Goss, G, Wain, G, Gard, G, Robertson, G, Lombard, J, Tan, J, McNeilage, J, Power, J, Coward, J, Miller, J, Carter, J, Lamont, J, Wong, KM, Reid, K, Perrin, L, Milishkin, L, Nascimento, M, Buck, M, Bunting, M, Harrison, M, Chetty, N, Hacker, N, McNally, O, Harnett, P, Beale, P, Awad, R, Mohan, R, Farrell, R, McIntosh, R, Rome, R, Sayer, R, Houghton, R, Hogg, R, Land, R, Baron-Hay, S, and Paramasivum, S

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Human Genome, Cancer, Prevention, Rare Diseases, Ovarian Cancer, Genetic Testing, Aetiology, 2.1 Biological and endogenous factors, Female, Humans, Carcinoma, Ovarian Epithelial, Genome-Wide Association Study, Alleles, DNA Copy Number Variations, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Ovarian Neoplasms, OPAL Study Group, AOCS Group, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundKnown risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort.MethodsSingle nucleotide polymorphism array data from 13 071 EOC cases and 17 306 controls of White European ancestry were used to identify CNVs associated with EOC risk using a rare admixture maximum likelihood test for gene burden and a by-probe ratio test. We performed enrichment analysis of CNVs at known EOC risk loci and functional biofeatures in ovarian cancer-related cell types.ResultsWe identified statistically significant risk associations with CNVs at known EOC risk genes; BRCA1 (PEOC = 1.60E-21; OREOC = 8.24), RAD51C (Phigh-grade serous ovarian cancer [HGSOC] = 5.5E-4; odds ratio [OR]HGSOC = 5.74 del), and BRCA2 (PHGSOC = 7.0E-4; ORHGSOC = 3.31 deletion). Four suggestive associations (P

Published
2022

3. Effect of newly developed pigments and ultraviolet absorbers on the color change of pigmented silicone elastomer

Author

Mohit G Kheur, Dilip Kakade, Coward J Trevor, Tabrez Amin Lakha, and Tania Sethi

Subjects
Color stability, elastomers, ultraviolet stabilizers, Dentistry, RK1-715
Abstract

Aim and Objective: The aim and objective of the study is to evaluate effect of ultraviolet (UV) stabilizer (UV absorber Chimassorb 81) on color change of pigmented silicone elastomer when commercially available (red and yellow), and newly developed pigments (sicotrans red and sicopal brown) were used. Materials and Methods: Two commercially available pigments – red (P112 Brilliant Red) and yellow (P106 Yellow) and two newly developed pigments – sicotrans red and sicopal brown were studied. In total eight groups made up of nine samples each were fabricated using elastomer with the combinations of the above pigments and UV stabilizer (Chimassorb 81). Groups 1, 3, 5, and 7 contain elastomer in combination with sicotrans red, sicopal brown, yellow and red pigments, respectively. Similarly, groups 2, 4, 6, and 8 along with elastomer and pigments (sicotrans sed, sicopal brown, yellow and red, respectively) contain the UV stabilizer (Chimassorb 81). Samples were subjected to aging in an accelerated weathering chamber (Weather-Ometer). Color values CIE (Commission Internationale d'Eclairage) L*, a*, and b * were measured at baseline and after 1000 h of weathering. Change in color (Delta E) was calculated. Results: All groups showed a significant color change at 1000 h. Groups 1, 2, 3, and 4 showed a statistically significant less change in both colors (sico trans red and sicopal brown) compared to groups 5,6,7, and 8 (commercial pigments-Red and Yellow). Overall, the change in the color in groups with the UV stabilizer (Chimassorb) was less when compared to the groups where the stabilizer was not used. Conclusion: The newly developed pigment led to increased color stability as compared to commercially available pigments. Addition of UV stabilizer, Chimassorb led to a further reduction in color change of the pigmented elastomer.

Published
2017
Full Text
View/download PDF

4. 126P AdvanTIG-105: Phase Ib dose-expansion study of ociperlimab (OCI) + tislelizumab (TIS) in patients (pts) with checkpoint inhibitor (CPI)-experienced advanced non-small cell lung cancer (NSCLC)

Author

Frentzas, S., primary, Meniawy, T., additional, Kao, S.C-H., additional, Coward, J., additional, Clay, T.D., additional, Singhal, N., additional, Black, A., additional, Xu, W., additional, Kumar, R., additional, Lee, Y., additional, Lee, G-W., additional, Liao, W., additional, Zhong, D., additional, Shiah, H-S., additional, Chen, Y-M., additional, Gao, R., additional, Wang, R., additional, Zheng, H., additional, Tan, W., additional, and Cho, E.K., additional

Published
2022
Full Text
View/download PDF

6. Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance

Author

He, Y, Wu, A C, Harrington, B S, Davies, C M, Wallace, S J, Adams, M N, Palmer, J S, Roche, D K, Hollier, B G, Westbrook, T F, Hamidi, H, Konecny, G E, Winterhoff, B, Chetty, N P, Crandon, A J, Oliveira, N B, Shannon, C M, Tinker, A V, Gilks, C B, Coward, J I, Lumley, J W, Perrin, L C, Armes, J E, and Hooper, J D

Published
2016
Full Text
View/download PDF

7. Entitäten-unabhängige Sicherheit und Wirksamkeit von Erdafitinib bei Patienten mit fortgeschrittenen soliden Tumoren mit präspezifizierten genomischen FGFR- Aberrationen (RAGNAR Interimanalyse)

Author

Schuler, Martin, Loriot, Y., Iyer, G., Witt, O., Doi, T., Qin, S., Tabernero, J., Reardon, D. A., Massard, C., Palmer, D. H., Lugowska, I., Coward, J., Corassa, M., Stuyckens, K., Liao, H., Najmi, S., Hammond, C., Santiago-Walker, A. E., Sweiti, H., and Pant, S.

Subjects
Medizin
Published
2022

10. 153P Safety/tolerability and antitumor activity of sitravatinib plus tislelizumab (TIS) in patients with advanced platinum-resistant ovarian cancer (PROC)

Author

Goh, J.C., primary, Coward, J., additional, Gao, B., additional, Pires Da Silva, I., additional, Voskoboynik, M., additional, Day, D., additional, Body, A., additional, Gan, H.K., additional, Li, X., additional, Sun, J., additional, Fei, C., additional, Yang, L., additional, and Millward, M., additional

Published
2021
Full Text
View/download PDF

12. Developing a multimodal biosensor for remote physiological monitoring

Author

Smith, Michael, Withnall, R, Anastasova, S, Gil-Rosa, B, Blackadder-Coward, J, and Taylor, N

Abstract

IntroductionSeveral UK military expeditions have successfully used physiological sensors to monitor participant’s physiological responses to challenging environmental conditions. This article describes the development and trial of a multimodal wearable biosensor that was used during the first all-female unassisted ski crossing of the Antarctic land mass. The project successfully transmitted remote real-time physiological data back to the UK. The ergonomic and technical lessons identified have informed recommendations for future wearable devices.MethodThe biosensor devices were designed to be continuously worn against the skin and capture: HR, ECG, body surface temperature, bioimpedance, perspiration pH, sodium, lactate and glucose. The data were transmitted from the devices to an android smartphone using near-field technology. A custom-built App running on an android smartphone managed the secure transmission of the data to a UK research centre, using a commercially available satellite transceiver.ResultsReal-time physiological data, captured by the multimodal device, was successfully transmitted back to a UK research control centre on 6 occasions. Postexpedition feedback from the participants has contributed to the ergonomic and technical refinement of the next generation of devices.ConclusionThe future success of wearable technologies lies in establishing clinical confidence in the quality of the measured data and the accurate interpretation of those data in the context of the individual, the environment and activity being undertaken. In the near future, wearable physiological monitoring could improve point-of-care diagnostic accuracy and inform critical medical and command decisions.

Published
2023
Full Text
View/download PDF

13. Measuring wet bulb globe temperatures at point-of-exertion in worldwide UK military settings: a longitudinal observational study determining the accuracy of a portable WBGT monitor

Author

Falconer Hall, Patricia, Blackadder-Coward, J, and Pynn, H

Abstract

IntroductionHeat illness among the UK Armed Forces is usually exertional, and therefore preventable, yet the incidence has not reduced since 2011. JSP 539 explicitly states that wet bulb globe temperature (WBGT) should be measured ‘at the location of greatest heat risk’, not ‘that of most convenience’. A handheld WBGT tracker used at point-of-exertion could reduce this incidence if proven to be as accurate as the current in-service device.MethodsLongitudinal observational comparison and equipment feasibility study of the Kestrel 5400 and QUESTemp 34 (QT-34) in worldwide firm base and deployed UK Armed Forces locations. The locations chosen were Kenya, South Sudan, Belize, Tidworth, Aldershot and Brecon. Paired data points of WBGT readings were collected from November 2017 to August 2018 in all weather conditions.ResultsWBGT readings were comparable between the QT-34 and Kestrel 5400 across the UK and overseas. In addition, there was no change in accuracy between readings taken from the Kestrel 5400 when tripod-mounted and handheld. The Kestrel was easy to set up and far less susceptible to resupply or power supply limitations, as it requires no user input for wet bulb temperature, and runs on AA batteries.ConclusionThis equipment feasibility study has shown that the Kestrel 5400 gives an acceptable accuracy and is easier to use than the QT-34. The authors recommend that the Kestrel 5400 is introduced as an adjunct to the QT-34, and its use within the military setting monitored through ongoing comparative data collection in a large-scale proof-of-concept study.

Published
2023
Full Text
View/download PDF

14. 1621P Efficacy and safety of erdafitinib in adults with pancreatic cancer and prespecified fibroblast growth factor receptor alterations (FGFRalt) in the phase II open-label: Single-arm RAGNAR trial

Author

Pant, S., Arnold, D., Tabernero, J., Loriot, Y., Folprecht, G., Haag, G.M., Palmer, D., Prenen, H., Coward, J., Lugowska, I., Goeminne, J-C., Cervantes, A., Gutierrez, M., Sweiti, H., Hammond, C., Najmi, S., Thomas, S., Triantos, S., Crow, L., and Schuler, M.H.H.

Published
2023
Full Text
View/download PDF

21. 157P Efficacy and safety of penpulimab (AK105), a new generation anti-programmed cell death-1 (PD-1) antibody, in upper gastrointestinal cancers

Author

Mislang, A.R.A., primary, Coward, J., additional, Cooper, A., additional, Underhill, C.R., additional, Zheng, Y., additional, Xu, N., additional, Xiao, C., additional, Jin, X., additional, Li, B., additional, Wang, M., additional, Kwek, K.Y., additional, Xia, D., additional, Xia, Y., additional, and Prawira, A., additional

Published
2020
Full Text
View/download PDF

22. 1021O Safety and antitumor activity of AK104, a bispecific antibody targeting PD-1 and CTLA-4, in patients with mesothelioma which is relapsed or refractory to standard therapies

Author

Millward, M., primary, Frentzas, S., additional, Gan, H.K., additional, Prawira, A., additional, Tran, B., additional, Coward, J., additional, Jin, X., additional, Li, B., additional, Wang, M., additional, Kwek, K.Y., additional, Xia, Y., additional, and Desai, J., additional

Published
2020
Full Text
View/download PDF

23. 1057P Preliminary pharmacokinetics (PK), safety and efficacy of two dosing regimens of CS1003 (anti-PD-1) in solid tumours: 200 mg every 3-week (Q3W) and 400 mg every 6-week (Q6W) dosing

Author

Markman, B., primary, Day, D., additional, Park, J.J.W., additional, Coward, J., additional, Bishnoi, S., additional, Kotasek, D., additional, Eek, R., additional, Brown, M.P., additional, Lemech, C., additional, Kuo, J., additional, Prawira, A., additional, Strother, R., additional, Zhang, Q., additional, Wang, L., additional, Chen, R., additional, Ma, Y., additional, Qin, Z., additional, and Tse, A., additional

Published
2020
Full Text
View/download PDF

24. Safety and Antitumor Activity of Sitravatinib in Combination with Tislelizumab in Patients With Advanced Solid Tumors: Ovarian Cancer Cohort Data

Author

Gao, B., primary, Goh, J., additional, Markman, B., additional, Voskoboynik, M., additional, Gan, H.K., additional, Coward, J., additional, Palmieri, D., additional, So, J., additional, Meniawy, T., additional, Chen, C., additional, Xiang, X., additional, Qiu, J., additional, Xu, Y., additional, Yang, L., additional, and Millward, M., additional

Published
2019
Full Text
View/download PDF

25. Updated results of activity of durvalumab in advanced endometrial cancer (AEC) according to mismatch repair (MMR) status: The phase II PHAEDRA trial (ANZGOG1601)

Author

Antill, Y., primary, Kok, P.S., additional, Stockler, M.R., additional, Robledo, K., additional, Yip, S., additional, Parry, M., additional, Smith, D., additional, Spurdle, A., additional, Barnes, E., additional, Friedlander, M.L., additional, Baron-Hay, S., additional, Shannon, C., additional, Coward, J., additional, Beale, P.J., additional, Goss, G., additional, Meniawy, T., additional, Andrews, J., additional, Kelly, M., additional, and Mileshkin, L., additional

Published
2019
Full Text
View/download PDF

30. Phase I/II study of CTLA-4 inhibitor AGEN1884 + PD-1 Inhibitor AGEN2034 in patients with advanced/refractory solid tumors, with expansion into 2L cervical cancer and solid tumors

Author

Coward, J., primary, Lemech, C., additional, Meniawy, T., additional, Dupont, C.D., additional, Gonzalez, A.M., additional, Lim, M., additional, Savitsky, D., additional, Carini, M., additional, Hu, S., additional, Shebanova, O., additional, Dow, E., additional, Ortuzar, W., additional, Buell, J.S., additional, Stein, R.B., additional, and Youssoufian, H., additional

Published
2018
Full Text
View/download PDF

32. Optimax 2016 : peer observation of facilitation

Author

Robinson, L, Coward, J, De Labouchere, S, Lowe, J, Mercer, CE, Palmqvist, C, and Takavol, P

Abstract

In August 2016, a 3-week research Summer School\ud was delivered at University of Salford. The Summer\ud School, known as ‘OPTIMAX’ was in its fourth year\ud of delivery. Previous iterations were held in the\ud Netherlands (2015), Portugal (2014) and Salford (2013).\ud The purpose of OPTIMAX is to facilitate collaborative\ud international and interdisciplinary research between\ud university academics and students. This offers an\ud exceptional opportunity not only for students, but also\ud for tutors who want to develop their facilitation skills.\ud The project reported here used tutor observers\ud (i.e. tutors who attend the summer school, in an\ud observational capacity only, to develop their own\ud skills as teachers) to observe, identify and reflect on a\ud range of facilitation practices for managing the diverse\ud OPTIMAX research groups. The project presents\ud a description of the peer-observation method we\ud used and highlights a number of findings related\ud to facilitator strategies that appeared to influence\ud group dynamics and learning. These observations\ud are then used to make recommendations about how\ud OPTIMAX tutors can be prepared for their facilitation\ud experience.

Published
2017

33. A review of the issues surrounding incidental findings on\ud CT attenuation correction (CTAC ) images during SPECT\ud myocardial perfusion imaging

Author

Coward, J

Abstract

Incidental findings are not uncommon on medical imaging with a particularly high prevalence identified in the chest. Pulmonary nodules contribute to a large proportion of incidental findings within the chest and these can often hinder definitive diagnosis because of their indeterminate nature. This is especially true of the incidental findings demonstrated on low-resolution CT images produced during CT attenuation correction (AC), as utilised in single-photon emission tomography (SPECT). The CTAC ‘images’ are effectively a by-product that were not intended for use in diagnosis.\ud \ud Although there is the potential for pulmonary nodules to become malignant, the majority will be benign. This gives rise to a high number of false-positive findings for CT imaging of the chest. The high number of false-positive findings identified on CTAC images raises an issue of whether these images should be reviewed. Whilst early detection of cancer could lead to earlier intervention and possibly improve prognosis, the high number of false-positive findings on CTAC images increases risks to the patient and does not necessarily raise the benefits. The non-diagnostic quality of CTAC images usually necessitates further diagnostic tests and possibly intervention before a definitive diagnosis can be reached.\ud \ud A balanced decision needs to be made on whether to interpret CTAC chest images, given the high number of false-positive findings, the potential psychological effects and harms to the patient. The recommendation of this review is that caution should be taken if routine reporting of CTAC images is to occur.

Published
2016

41. Lesion detection performance in an anthropomorphic chest phantom: comparative analysis of low-dose CT data on two hybrid imaging systems

Author

Jessop, M., Thompson, John D., Coward, J., Sanderud, Audun, Jorge, José, de Groot, M., Lança, Luís, and Hogg, Peter

Subjects
Imaging system, Phantom, Dosimetry, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Anthropomorphic chest, Radiology
Abstract

Introduction: multimodality environment; requirement for greater understanding of the imaging technologies used, the limitations of these technologies, and how to best interpret the results; dose optimization; introduction of new techniques; current practice and best practice; incidental findings, in low-dose CT images obtained as part of the hybrid imaging process, are an increasing phenomenon with advancing CT technology; resultant ethical and medico-legal dilemmas; understanding limitations of these procedures important when reporting images and recommending follow-up; free-response observer performance study was used to evaluate lesion detection in low-dose CT images obtained during attenuation correction acquisitions for myocardial perfusion imaging, on two hybrid imaging systems.

Published
2014

44. Effect of newly developed pigments and ultraviolet absorbers on the color change of pigmented silicone elastomer.

Author

Kheur, Mohit G., Kakade, Dilip, Trevor, Coward J., Lakha, Tabrez Amin, and Sethi, Tania

Subjects
SILICONE rubber, COLOR, PIGMENTS, LIGHT absorption, ULTRAVIOLET radiation
Abstract

Aim and Objective: The aim and objective of the study is to evaluate effect of ultraviolet (UV) stabilizer (UV absorber Chimassorb 81) on color change of pigmented silicone elastomer when commercially available (red and yellow), and newly developed pigments (sicotrans red and sicopal brown) were used. Materials and Methods: Two commercially available pigments - red (P112 Brilliant Red) and yellow (P106 Yellow) and two newly developed pigments - sicotrans red and sicopal brown were studied. In total eight groups made up of nine samples each were fabricated using elastomer with the combinations of the above pigments and UV stabilizer (Chimassorb 81). Groups 1, 3, 5, and 7 contain elastomer in combination with sicotrans red, sicopal brown, yellow and red pigments, respectively. Similarly, groups 2, 4, 6, and 8 along with elastomer and pigments (sicotrans sed, sicopal brown, yellow and red, respectively) contain the UV stabilizer (Chimassorb 81). Samples were subjected to aging in an accelerated weathering chamber (Weather-Ometer). Color values CIE (Commission Internationale d'Eclairage) L*, a*, and b * were measured at baseline and after 1000 h of weathering. Change in color (Delta E) was calculated. Results: All groups showed a significant color change at 1000 h. Groups 1, 2, 3, and 4 showed a statistically significant less change in both colors (sico trans red and sicopal brown) compared to groups 5,6,7, and 8 (commercial pigments-Red and Yellow). Overall, the change in the color in groups with the UV stabilizer (Chimassorb) was less when compared to the groups where the stabilizer was not used. Conclusion: The newly developed pigment led to increased color stability as compared to commercially available pigments. Addition of UV stabilizer, Chimassorb led to a further reduction in color change of the pigmented elastomer. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

45. An Archaeological Strip, Plan and Sample excavation at 5 Coventry Rd

Author

Coward, J.

Subjects
Archaeology, Grey Literature
Abstract

An archaeological strip, plan and sample excavation was undertaken by University of Leicester Archaeological Services in August 2012 at 5 Coventry Road, Brinklow, Warwickshire SP 4342 792. The work was carried out in advance of an extension to the dwelling dwelling. No archaeological activity or artefacts were revealed during the course of the work. The archive will be deposited with Warwickshire Museums under code T/1182 in due course.

Published
2012
Full Text
View/download PDF

47. Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance

Author

He, Y, primary, Wu, A C, additional, Harrington, B S, additional, Davies, C M, additional, Wallace, S J, additional, Adams, M N, additional, Palmer, J S, additional, Roche, D K, additional, Hollier, B G, additional, Westbrook, T F, additional, Hamidi, H, additional, Konecny, G E, additional, Winterhoff, B, additional, Chetty, N P, additional, Crandon, A J, additional, Oliveira, N B, additional, Shannon, C M, additional, Tinker, A V, additional, Gilks, C B, additional, Coward, J I, additional, Lumley, J W, additional, Perrin, L C, additional, Armes, J E, additional, and Hooper, J D, additional

Published
2015
Full Text
View/download PDF

49. An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of severe neutropenic toxicity

Author

Minchom, A R, primary, Saksornchai, K, additional, Bhosle, J, additional, Gunapala, R, additional, Puglisi, M, additional, Lu, S K, additional, Nimako, K, additional, Coward, J, additional, Yu, K C, additional, Bordi, P, additional, Popat, S, additional, and O'Brien, M E R, additional

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results