Search

Your search keyword '"Covello, Remo Daniel"' showing total 165 results
Start Over Author "Covello, Remo Daniel"
165 results on '"Covello, Remo Daniel"'

1. Nonsurgical Strategies to Reduce Mortality in Patients Undergoing Cardiac Surgery: An Updated Consensus Process

Author

Landoni, Giovanni, Lomivorotov, Vladimir, Silvetti, Simona, Nigro Neto, Caetano, Pisano, Antonio, Alvaro, Gabriele, Hajjar, Ludmilla Abrahao, Paternoster, Gianluca, Riha, Hynek, Monaco, Fabrizio, Szekely, Andrea, Lembo, Rosalba, Aslan, Nesrin A., Affronti, Giovanni, Likhvantsev, Valery, Amarelli, Cristiano, Fominskiy, Evgeny, Baiardo Redaelli, Martina, Putzu, Alessandro, Baiocchi, Massimo, Ma, Jun, Bono, Giuseppe, Camarda, Valentina, Covello, Remo Daniel, Di Tomasso, Nora, Labonia, Miriam, Leggieri, Carlo, Lobreglio, Rosetta, Monti, Giacomo, Mura, Paolo, Scandroglio, Anna Mara, Pasero, Daniela, Turi, Stefano, Roasio, Agostino, Votta, Carmine D., Saporito, Emanuela, Riefolo, Claudio, Sartini, Chiara, Brazzi, Luca, Bellomo, Rinaldo, and Zangrillo, Alberto

Published
2018
Full Text
View/download PDF

4. Early and Midterm Outcome of Propensity-Matched Intermediate-Risk Patients Aged ≥80 Years With Aortic Stenosis Undergoing Surgical or Transcatheter Aortic Valve Replacement (from the Italian Multicenter OBSERVANT Study)

Author

Fraccaro, Chiara, Tarantini, Giuseppe, Rosato, Stefano, Tellaroli, Paola, D'Errigo, Paola, Tamburino, Corrado, Onorati, Francesco, Ranucci, Marco, Barbanti, Marco, Grossi, Claudio, Santoro, Gennaro, Santini, Francesco, Covello, Remo Daniel, Fusco, Danilo, and Seccareccia, Fulvia

Published
2016
Full Text
View/download PDF

9. Usefulness of Baseline Activated Clotting Time–Guided Heparin Administration in Reducing Bleeding Events During Transfemoral Transcatheter Aortic Valve Implantation

Author

Bernelli, Chiara, Chieffo, Alaide, Montorfano, Matteo, Maisano, Francesco, Giustino, Gennaro, Buchanan, Gill Louise, Chan, Jaclyn, Costopoulos, Charis, Latib, Azeem, Figini, Filippo, De Meo, Ermelinda, Giannini, Francesco, Covello, Remo Daniel, Gerli, Chiara, Franco, Annalisa, Agricola, Eustachio, Spagnolo, Pietro, Cioni, Micaela, Alfieri, Ottavio, Camici, Paolo Guido, and Colombo, Antonio

Published
2014
Full Text
View/download PDF

19. Noninvasive Ventilatory Support of Patients with COVID-19 outside the Intensive Care Units (WARd-COVID)

Author

Bellani, Giacomo, primary, Grasselli, Giacomo, additional, Cecconi, Maurizio, additional, Antolini, Laura, additional, Borelli, Massimo, additional, De Giacomi, Federica, additional, Bosio, Giancarlo, additional, Latronico, Nicola, additional, Filippini, Matteo, additional, Gemma, Marco, additional, Giannotti, Claudia, additional, Antonini, Benvenuto, additional, Petrucci, Nicola, additional, Zerbi, Simone Maria, additional, Maniglia, Paolo, additional, Castelli, Gian Paolo, additional, Marino, Giovanni, additional, Subert, Matteo, additional, Citerio, Giuseppe, additional, Radrizzani, Danilo, additional, Mediani, Teresa S., additional, Lorini, Ferdinando Luca, additional, Russo, Filippo Maria, additional, Faletti, Angela, additional, Beindorf, Andrea, additional, Covello, Remo Daniel, additional, Greco, Stefano, additional, Bizzarri, Marta M., additional, Ristagno, Giuseppe, additional, Mojoli, Francesco, additional, Pradella, Andrea, additional, Severgnini, Paolo, additional, Da Macallè, Marta, additional, Albertin, Andrea, additional, Ranieri, V. Marco, additional, Rezoagli, Emanuele, additional, Vitale, Giovanni, additional, Magliocca, Aurora, additional, Cappelleri, Gianluca, additional, Docci, Mattia, additional, Aliberti, Stefano, additional, Serra, Filippo, additional, Rossi, Emanuela, additional, Valsecchi, Maria Grazia, additional, Pesenti, Antonio, additional, and Foti, Giuseppe, additional

Published
2021
Full Text
View/download PDF

20. Noninvasive Ventilatory Support of COVID-19 Patients Outside the Intensive Care Units (WARd-COVID)

Author

Bellani, G, Grasselli, G, Cecconi, M, Antolini, L, Borelli, M, De Giacomi, F, Bosio, G, Latronico, N, Filippini, M, Gemma, M, Giannotti, C, Antonini, B, Petrucci, N, Zerbi, S, Maniglia, P, Castelli, G, Marino, G, Subert, M, Citerio, G, Radrizzani, D, Mediani, T, Lorini, F, Russo, F, Faletti, A, Beindorf, A, Covello, R, Greco, S, Bizzarri, M, Ristagno, G, Mojoli, F, Pradella, A, Severgnini, P, Da Macallè, M, Albertin, A, Ranieri, V, Rezoagli, E, Vitale, G, Magliocca, A, Cappelleri, G, Docci, M, Aliberti, S, Serra, F, Rossi, E, Valsecchi, M, Pesenti, A, Foti, G, Bellani, Giacomo, Grasselli, Giacomo, Cecconi, Maurizio, Antolini, Laura, Borelli, Massimo, De Giacomi, Federica, Bosio, Giancarlo, Latronico, Nicola, Filippini, Matteo, Gemma, Marco, Giannotti, Claudia, Antonini, Benvenuto, Petrucci, Nicola, Zerbi, Simone Maria, Maniglia, Paolo, Castelli, Gian Paolo, Marino, Giovanni, Subert, Matteo, Citerio, Giuseppe, Radrizzani, Danilo, Mediani, Teresa S, Lorini, Ferdinando Luca, Russo, Filippo Maria, Faletti, Angela, Beindorf, Andrea, Covello, Remo Daniel, Greco, Stefano, Bizzarri, Marta M, Ristagno, Giuseppe, Mojoli, Francesco, Pradella, Andrea, Severgnini, Paolo, Da Macallè, Marta, Albertin, Andrea, Ranieri, V Marco, Rezoagli, Emanuele, Vitale, Giovanni, Magliocca, Aurora, Cappelleri, Gianluca, Docci, Mattia, Aliberti, Stefano, Serra, Filippo, Rossi, Emanuela, Valsecchi, Maria Grazia, Pesenti, Antonio, Foti, Giuseppe, Bellani, G, Grasselli, G, Cecconi, M, Antolini, L, Borelli, M, De Giacomi, F, Bosio, G, Latronico, N, Filippini, M, Gemma, M, Giannotti, C, Antonini, B, Petrucci, N, Zerbi, S, Maniglia, P, Castelli, G, Marino, G, Subert, M, Citerio, G, Radrizzani, D, Mediani, T, Lorini, F, Russo, F, Faletti, A, Beindorf, A, Covello, R, Greco, S, Bizzarri, M, Ristagno, G, Mojoli, F, Pradella, A, Severgnini, P, Da Macallè, M, Albertin, A, Ranieri, V, Rezoagli, E, Vitale, G, Magliocca, A, Cappelleri, G, Docci, M, Aliberti, S, Serra, F, Rossi, E, Valsecchi, M, Pesenti, A, Foti, G, Bellani, Giacomo, Grasselli, Giacomo, Cecconi, Maurizio, Antolini, Laura, Borelli, Massimo, De Giacomi, Federica, Bosio, Giancarlo, Latronico, Nicola, Filippini, Matteo, Gemma, Marco, Giannotti, Claudia, Antonini, Benvenuto, Petrucci, Nicola, Zerbi, Simone Maria, Maniglia, Paolo, Castelli, Gian Paolo, Marino, Giovanni, Subert, Matteo, Citerio, Giuseppe, Radrizzani, Danilo, Mediani, Teresa S, Lorini, Ferdinando Luca, Russo, Filippo Maria, Faletti, Angela, Beindorf, Andrea, Covello, Remo Daniel, Greco, Stefano, Bizzarri, Marta M, Ristagno, Giuseppe, Mojoli, Francesco, Pradella, Andrea, Severgnini, Paolo, Da Macallè, Marta, Albertin, Andrea, Ranieri, V Marco, Rezoagli, Emanuele, Vitale, Giovanni, Magliocca, Aurora, Cappelleri, Gianluca, Docci, Mattia, Aliberti, Stefano, Serra, Filippo, Rossi, Emanuela, Valsecchi, Maria Grazia, Pesenti, Antonio, and Foti, Giuseppe

Abstract

Rationale: Treatment with noninvasive ventilation (NIV) in coronavirus disease (COVID-19) is frequent. Shortage of intensive care unit (ICU) beds led clinicians to deliver NIV also outside ICUs. Data about the use of NIV in COVID-19 is limited. Objectives: To describe the prevalence and clinical characteristics of patientswith COVID-19 treated with NIVoutside the ICUs. To investigate the factors associated with NIV failure (need for intubation or death). Methods: In this prospective, single-day observational study, we enrolled adult patients with COVID-19 who were treated with NIV outside the ICU from 31 hospitals in Lombardy, Italy. Results: We collected data on demographic and clinical characteristics, ventilatorymanagement, and patient outcomes.Of 8,753 patients with COVID-19 present in the hospitals on the study day, 909 (10%) were receiving NIV outside the ICU. A majority of patients (778/909; 85%) patients were treated with continuous positive airway pressure (CPAP), which was delivered by helmet in 617 (68%) patients. NIV failed in 300 patients (37.6%), whereas 498 (62.4%) patients were discharged alive without intubation. Overall mortality was 25%. NIV failure occurred in 152/284 (53%) patients with an arterial oxygen pressure (PaO2)/fraction of inspired oxygen (FIO2) ratio ,150 mm Hg. Higher C-reactive protein and lower PaO2/FIO2 and platelet counts were independently associated with increased risk of NIV failure. Conclusions: The use of NIV outside the ICUs was common in COVID-19, with a predominant use of helmet CPAP, with a rate of success.60% and close to 75% in full-treatment patients. C-reactive protein, PaO2/FIO2, and platelet counts were independently associated with increased risk of NIV failure.

Published
2021

21. Different impact of sex on baseline characteristics and major periprocedural outcomes of transcatheter and surgical aortic valve interventions: Results of the multicenter Italian OBSERVANT Registry

Author

Onorati, Francesco, D’Errigo, Paola, Barbanti, Marco, Rosato, Stefano, Covello, Remo Daniel, Maraschini, Alice, Ranucci, Marco, Santoro, Gennaro, Tamburino, Corrado, Grossi, Claudio, Santini, Francesco, Menicanti, Lorenzo, and Seccareccia, Fulvia

Published
2014
Full Text
View/download PDF

22. A Comparison of the Femoral and Radial Crossover Techniques for Vascular Access Management in Transcatheter Aortic Valve Implantation: The Milan Experience

Author

Curran, Helen, Chieffo, Alaide, Buchanan, Gill Louise, Bernelli, Chiara, Montorfano, Matteo, Maisano, Francesco, Latib, Azeem, Maccagni, Davide, Carlino, Mauro, Figini, Filippo, Cioni, Micaela, Canna, Giovanni La, Covello, Remo Daniel, Franco, Annalisa, Gerli, Chiara, Alfieri, Ottavio, and Colombo, Antonio

Published
2014
Full Text
View/download PDF

24. Transcatheter vs surgical aortic valve replacement in intermediate-surgical-risk patients with aortic stenosis: A propensity score-matched case-control study

Author

Latib, Azeem, Maisano, Francesco, Bertoldi, Letizia, Giacomini, Andrea, Shannon, Joanne, Cioni, Micaela, Ielasi, Alfonso, Figini, Filippo, Tagaki, Kensuke, Franco, Annalisa, Covello, Remo Daniel, Grimaldi, Antonio, Spagnolo, Pietro, Buchannan, Gill Louise, Carlino, Mauro, Chieffo, Alaide, Montorfano, Matteo, Alfieri, Ottavio, and Colombo, Antonio

Published
2012
Full Text
View/download PDF

26. Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy

Author

Grasselli, Giacomo, Greco, Massimiliano, Zanella, Alberto, Albano, Giovanni, Antonelli, Massimo, Bellani, Giacomo, Bonanomi, Ezio, Cabrini, Luca, Carlesso, Eleonora, Castelli, Gianpaolo, Cattaneo, Sergio, Cereda, Danilo, Colombo, Sergio, Coluccello, Antonio, Crescini, Giuseppe, Forastieri Molinari, Andrea, Foti, Giuseppe, Fumagalli, Roberto, Iotti, Giorgio Antonio, Langer, Thomas, Latronico, Nicola, Lorini, Ferdinando Luca, Mojoli, Francesco, Natalini, Giuseppe, Pessina, Carla Maria, Ranieri, Vito Marco, Rech, Roberto, Scudeller, Luigia, Rosano, Antonio, Storti, Enrico, Thompson, B. Taylor, Tirani, Marcello, Villani, Pier Giorgio, Pesenti, Antonio, Cecconi, Maurizio, Agosteo, Emiliano, Albertin, Andrea, Alborghetti, Armando, Aldegheri, Giorgio, Antonini, Benvenuto, Barbara, Enrico, Bardelloni, Giulia, Basilico, Sabrina, Belgiorno, Nicolangela, Beretta, Enrico, Berselli, Angela, Bianciardi, Leonardo, Bonazzi, Stefano, Borelli, Massimo, Bottino, Nicola, Bronzini, Nicola, Brusatori, Serena, Capra, Carlo, Carnevale, Livio, Catena, Emanuele, Celotti, Simona, Cerutti, Stefania, Chiumello, Davide, Cirri, Silvia, Citerio, Giuseppe, Coppini, Davide, Corona, Alberto, Cortellazzi, Paolo, Costantini, Elena, Covello, Remo Daniel, De Filippi, Gianluca, Dei Poli, Marco, Dughi, Paolo, Fieni, Fulvia, Florio, Gaetano, Galletti, Marco, Gallioli, Giorgio Antonio, Gay, Hedwige, Gemma, Marco, Gnesin, Paolo, Greco, Stefano, Grosso, Paolo, Guatteri, Luca, Guzzon, Davide, Keim, Roberto, Lombardo, Andrea, Mamprin, Filippo, Marino, Giovanni, Marino, Francesco, Merli, Guido, Micucci, Antonio, Militano, Carmine Rocco, Monti, Giacomo, Muttini, Stefano, Nadalin, Samantha, Perazzo, Paolo, Perego, Giovanni Battista, Perotti, Luciano, Petrucci, Nicola, Pezzi, Angelo, Piva, Simone, Portella, Gina, Protti, Alessandro, Racagni, Milena, Radrizzani, Danilo, Raimondi, Maurizio, Ranucci, Marco, Riccio, Mario, Ruggeri, Patrizia, Sala, Giuseppe, Salvi, Luca, Sebastiano, Pietro, Severgnini, Paolo, Sigurtà, Donato, Stocchetti, Nino, Subert, Matteo, Tavola, Mario, Todaro, Serena, Torriglia, Francesca, Tubiolo, Daniela, Valsecchi, Roberto, Viola, Uberto, Vitale, Giovanni, Zambon, Massimo, Zoia, Elena, Grasselli, G, Greco, M, Zanella, A, Albano, G, Antonelli, M, Bellani, G, Bonanomi, E, Cabrini, L, Carlesso, E, Castelli, G, Cattaneo, S, Cereda, D, Colombo, S, Coluccello, A, Crescini, G, Forastieri Molinari, A, Foti, G, Fumagalli, R, Iotti, G, Langer, T, Latronico, N, Lorini, F, Mojoli, F, Natalini, G, Pessina, C, Ranieri, V, Rech, R, Scudeller, L, Rosano, A, Storti, E, Thompson, B, Tirani, M, Villani, P, Pesenti, A, Cecconi, M, Grasselli G., Greco M., Zanella A., Albano G., Antonelli M., Bellani G., Bonanomi E., Cabrini L., Carlesso E., Castelli G., Cattaneo S., Cereda D., Colombo S., Coluccello A., Crescini G., Forastieri Molinari A., Foti G., Fumagalli R., Iotti G.A., Langer T., Latronico N., Lorini F.L., Mojoli F., Natalini G., Pessina C.M., Ranieri V.M., Rech R., Scudeller L., Rosano A., Storti E., Thompson B.T., Tirani M., Villani P.G., Pesenti A., and Cecconi M.

Subjects
medicine.medical_specialty, COVID19, mechanical ventilation, 01 natural sciences, law.invention, 03 medical and health sciences, 0302 clinical medicine, COVID-19, ICU, critical illness, mechanical ventilation, mortality, Interquartile range, law, Intensive care, Internal medicine, Internal Medicine, critical illness, Medicine, 030212 general & internal medicine, 0101 mathematics, Risk factor, business.industry, Mortality rate, 010102 general mathematics, Hazard ratio, COVID-19, Retrospective cohort study, mortality, Intensive care unit, ICU, na, business, Cohort study
Abstract

Importance Many patients with coronavirus disease 2019 (COVID-19) are critically ill and require care in the intensive care unit (ICU). Objective To evaluate the independent risk factors associated with mortality of patients with COVID-19 requiring treatment in ICUs in the Lombardy region of Italy. Design, Setting, and Participants This retrospective, observational cohort study included 3988 consecutive critically ill patients with laboratory-confirmed COVID-19 referred for ICU admission to the coordinating center (Fondazione IRCCS [Istituto di Ricovero e Cura a Carattere Scientifico] Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy) of the COVID-19 Lombardy ICU Network from February 20 to April 22, 2020. Infection with severe acute respiratory syndrome coronavirus 2 was confirmed by real-time reverse transcriptase–polymerase chain reaction assay of nasopharyngeal swabs. Follow-up was completed on May 30, 2020. Exposures Baseline characteristics, comorbidities, long-term medications, and ventilatory support at ICU admission. Main Outcomes and Measures Time to death in days from ICU admission to hospital discharge. The independent risk factors associated with mortality were evaluated with a multivariable Cox proportional hazards regression. Results Of the 3988 patients included in this cohort study, the median age was 63 (interquartile range [IQR] 56-69) years; 3188 (79.9%; 95% CI, 78.7%-81.1%) were men, and 1998 of 3300 (60.5%; 95% CI, 58.9%-62.2%) had at least 1 comorbidity. At ICU admission, 2929 patients (87.3%; 95% CI, 86.1%-88.4%) required invasive mechanical ventilation (IMV). The median follow-up was 44 (95% CI, 40-47; IQR, 11-69; range, 0-100) days; median time from symptoms onset to ICU admission was 10 (95% CI, 9-10; IQR, 6-14) days; median length of ICU stay was 12 (95% CI, 12-13; IQR, 6-21) days; and median length of IMV was 10 (95% CI, 10-11; IQR, 6-17) days. Cumulative observation time was 164 305 patient-days. Hospital and ICU mortality rates were 12 (95% CI, 11-12) and 27 (95% CI, 26-29) per 1000 patients-days, respectively. In the subgroup of the first 1715 patients, as of May 30, 2020, 865 (50.4%) had been discharged from the ICU, 836 (48.7%) had died in the ICU, and 14 (0.8%) were still in the ICU; overall, 915 patients (53.4%) died in the hospital. Independent risk factors associated with mortality included older age (hazard ratio [HR], 1.75; 95% CI, 1.60-1.92), male sex (HR, 1.57; 95% CI, 1.31-1.88), high fraction of inspired oxygen (Fio2) (HR, 1.14; 95% CI, 1.10-1.19), high positive end-expiratory pressure (HR, 1.04; 95% CI, 1.01-1.06) or low Pao2:Fio2ratio (HR, 0.80; 95% CI, 0.74-0.87) on ICU admission, and history of chronic obstructive pulmonary disease (HR, 1.68; 95% CI, 1.28-2.19), hypercholesterolemia (HR, 1.25; 95% CI, 1.02-1.52), and type 2 diabetes (HR, 1.18; 95% CI, 1.01-1.39). No medication was independently associated with mortality (angiotensin-converting enzyme inhibitors HR, 1.17; 95% CI, 0.97-1.42; angiotensin receptor blockers HR, 1.05; 95% CI, 0.85-1.29). Conclusions and Relevance In this retrospective cohort study of critically ill patients admitted to ICUs in Lombardy, Italy, with laboratory-confirmed COVID-19, most patients required IMV. The mortality rate and absolute mortality were high.

Published
2020

27. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

Author

Grasselli, Giacomo, Zangrillo, Alberto, Zanella, Alberto, Antonelli, Massimo, Cabrini, Luca, Castelli, Antonio, Cereda, Danilo, Coluccello, Antonio, Foti, Giuseppe, Fumagalli, Roberto, Iotti, Giorgio, Latronico, Nicola, Lorini, Luca, Merler, Stefano, Natalini, Giuseppe, Piatti, Alessandra, Ranieri, Marco Vito, Scandroglio, Anna Mara, Storti, Enrico, Cecconi, Maurizio, Pesenti, Antonio, Agosteo, Emiliano, Alaimo, Valentina, Albano, Giovanni, Albertin, Andrea, Alborghetti, Armando, Aldegheri, Giorgio, Antonini, Benvenuto, Barbara, Enrico, Belgiorno, Nicolangela, Belliato, Mirko, Benini, Annalisa, Beretta, Enrico, Bianciardi, Leonardo, Bonazzi, Stefano, Borelli, Massimo, Boselli, Enrico, Bronzini, Nicola, Capra, Carlo, Carnevale, Livio, Casella, Giampaolo, Castelli, Gianpaolo, Catena, Emanuele, Cattaneo, Sergio, Chiumello, Davide, Cirri, Silvia, Citerio, Giuseppe, Colombo, Sergio, Coppini, Davide, Corona, Alberto, Cortellazzi, Paolo, Costantini, Elena, Covello, Remo Daniel, De Filippi, Gianluca, Dei Poli, Marco, Della Mura, Federica, Evasi, Giulia, Fernandez-Olmos, Raquel, Forastieri Molinari, Andrea, Galletti, Marco, Gallioli, Giorgio, Gemma, Marco, Gnesin, Paolo, Grazioli, Lorenzo, Greco, Stefano, Gritti, Paolo, Grosso, Paolo, Guatteri, Luca, Guzzon, Davide, Harizay, Fabiola, Keim, Roberto, Landoni, Giovanni, Langer, Thomas, Lombardo, Andrea, Malara, Annalisa, Malpetti, Elena, Marino, Francesco, Marino, Giovanni, Mazzoni, Maurizio Giovanni, Merli, Guido, Micucci, Antonio, Mojoli, Francesco, Muttini, Stefano, Nailescu, Adriana, Panigada, Mauro, Perazzo, Paolo, Perego, Giovanni Battista, Petrucci, Nicola, Pezzi, Angelo, Protti, Alessandro, Radrizzani, Danilo, Raimondi, Maurizio, Ranucci, Marco, Rasulo, Frank, Riccio, Mario, Rona, Roberto, Roscitano, Claudio, Ruggeri, Patrizia, Sala, Antonello, Sala, Giuseppe, Salvi, Luca, Sebastiano, Pietro, Severgnini, Paolo, Sforzini, Ilaria, Sigurtà, Francesco Donato, Subert, Matteo, Tagliabue, Paola, Troiano, Carmine, Valsecchi, Roberto, Viola, Uberto, Vitale, Giovanni, Zambon, Massimo, Zoia, Elena, Grasselli, G, Zangrillo, A, Zanella, A, Antonelli, M, Cabrini, L, Castelli, A, Cereda, D, Coluccello, A, Foti, G, Fumagalli, R, Iotti, G, Latronico, N, Lorini, L, Merler, S, Natalini, G, Piatti, A, Ranieri, Mv, Scandroglio, Am, Storti, E, Cecconi, M, Pesenti, A (COVID-19 Lombardy ICU Network), Landoni, G, Ranieri, M, Scandroglio, A, Pesenti, A, and Lorini, F

Subjects
Artificial ventilation, medicine.medical_specialty, medicine.medical_treatment, 01 natural sciences, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Intensive care, Internal medicine, Settore MED/41 - ANESTESIOLOGIA, Medicine, 030212 general & internal medicine, 0101 mathematics, Positive end-expiratory pressure, Original Investigation, Mechanical ventilation, SARS-CoV-2, business.industry, 010102 general mathematics, Retrospective cohort study, General Medicine, medicine.disease, Comorbidity, Intensive care unit, Respiratory failure, SARS-CoV-2, ICU, business
Abstract

Question What are the baseline characteristics and outcomes of patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection admitted to intensive care units (ICUs) in Lombardy, Italy? Findings In this retrospective case series that involved 1591 critically ill patients admitted from February 20 to March 18, 2020, 99% (1287 of 1300 patients) required respiratory support, including endotracheal intubation in 88% and noninvasive ventilation in 11%; ICU mortality was 26%. Meaning In this case series of critically ill patients admitted to ICUs in Lombardy, Italy, with laboratory-confirmed coronavirus disease 2019 (COVID-19), a high proportion required mechanical ventilation and ICU mortality was 26% as of March 25, 2020.Importance In December 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged in China and has spread globally, creating a pandemic. Information about the clinical characteristics of infected patients who require intensive care is limited. Objective To characterize patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) in the Lombardy region of Italy. Design, Setting, and Participants Retrospective case series of 1591 consecutive patients with laboratory-confirmed COVID-19 referred for ICU admission to the coordinator center (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy) of the COVID-19 Lombardy ICU Network and treated at one of the ICUs of the 72 hospitals in this network between February 20 and March 18, 2020. Date of final follow-up was March 25, 2020. Exposures SARS-CoV-2 infection confirmed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay of nasal and pharyngeal swabs. Main Outcomes and Measures Demographic and clinical data were collected, including data on clinical management, respiratory failure, and patient mortality. Data were recorded by the coordinator center on an electronic worksheet during telephone calls by the staff of the COVID-19 Lombardy ICU Network. Results Of the 1591 patients included in the study, the median (IQR) age was 63 (56-70) years and 1304 (82%) were male. Of the 1043 patients with available data, 709 (68%) had at least 1 comorbidity and 509 (49%) had hypertension. Among 1300 patients with available respiratory support data, 1287 (99% [95% CI, 98%-99%]) needed respiratory support, including 1150 (88% [95% CI, 87%-90%]) who received mechanical ventilation and 137 (11% [95% CI, 9%-12%]) who received noninvasive ventilation. The median positive end-expiratory pressure (PEEP) was 14 (IQR, 12-16) cm H2O, and Fio(2) was greater than 50% in 89% of patients. The median Pao(2)/Fio(2) was 160 (IQR, 114-220). The median PEEP level was not different between younger patients (n = 503 aged = 64 years) (14 [IQR, 12-15] vs 14 [IQR, 12-16] cm H2O, respectively; median difference, 0 [95% CI, 0-0]; P = .94). Median Fio(2) was lower in younger patients: 60% (IQR, 50%-80%) vs 70% (IQR, 50%-80%) (median difference, -10% [95% CI, -14% to 6%]; P = .006), and median Pao(2)/Fio(2) was higher in younger patients: 163.5 (IQR, 120-230) vs 156 (IQR, 110-205) (median difference, 7 [95% CI, -8 to 22]; P = .02). Patients with hypertension (n = 509) were older than those without hypertension (n = 526) (median [IQR] age, 66 years [60-72] vs 62 years [54-68]; P < .001) and had lower Pao(2)/Fio(2) (median [IQR], 146 [105-214] vs 173 [120-222]; median difference, -27 [95% CI, -42 to -12]; P = .005). Among the 1581 patients with ICU disposition data available as of March 25, 2020, 920 patients (58% [95% CI, 56%-61%]) were still in the ICU, 256 (16% [95% CI, 14%-18%]) were discharged from the ICU, and 405 (26% [95% CI, 23%-28%]) had died in the ICU. Older patients (n = 786; age >= 64 years) had higher mortality than younger patients (n = 795; age

Published
2020

28. Reply: TAVI in Lower Risk Patients: Revolution or Nonsense? Keep Calm and Select Patients

Author

Barbanti, Marco, Tamburino, Corrado, D'Errigo, Paola, Ranucci, Marco, Onorati, Francesco, Covello, Remo Daniel, Santini, Francesco, Rosato, Stefano, Santoro, Gennaro, Fusco, Danilo, Grossi, Claudio, and Seccareccia, Fulvia

Subjects
Male, Transcatheter Aortic Valve Replacement, Aortic Valve Stenosis, Female, Humans, Cardiology and Cardiovascular Medicine
Published
2016

29. 1-year outcomes after transfemoral transcatheter or surgical aortic valve replacement. Results from the Italian OBSERVANT study

Author

Tamburino, Corrado, Barbanti, Marco, D'Errigo, Paola, Ranucci, Marco, Onorati, Francesco, Covello, Remo Daniel, Santini, Francesco, Rosato, Stefano, Santoro, Gennaro, Fusco, Danilo, Grossi, Claudio, Seccareccia, Fulvia, Collaborators, and Sinatra, Riccardo

Subjects
Heart Valve Prosthesis Implantation, Male, Time Factors, Medicine (all), aortic stenosis, intermediate risk, Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement, implantation, transcatheter aortic valve, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Italy, Mortality, Prospective Studies, Treatment Outcome, Cardiology and Cardiovascular Medicine, 80 and over
Published
2015

31. Transcatheter Aortic Valve Implantation Compared With Surgical Aortic Valve Replacement in Low-Risk Patients

Author

Rosato, Stefano, primary, Santini, Francesco, additional, Barbanti, Marco, additional, Biancari, Fausto, additional, D’Errigo, Paola, additional, Onorati, Francesco, additional, Tamburino, Corrado, additional, Ranucci, Marco, additional, Covello, Remo Daniel, additional, Santoro, Gennaro, additional, Grossi, Claudio, additional, Ventura, Martina, additional, Fusco, Danilo, additional, and Seccareccia, Fulvia, additional

Published
2016
Full Text
View/download PDF

32. Reply

Author

Barbanti, Marco, primary, Tamburino, Corrado, additional, D’Errigo, Paola, additional, Ranucci, Marco, additional, Onorati, Francesco, additional, Covello, Remo Daniel, additional, Santini, Francesco, additional, Rosato, Stefano, additional, Santoro, Gennaro, additional, Fusco, Danilo, additional, Grossi, Claudio, additional, and Seccareccia, Fulvia, additional

Published
2016
Full Text
View/download PDF

33. 1-Year Outcomes After Transfemoral Transcatheter or Surgical Aortic Valve Replacement

Author

Tamburino, Corrado, primary, Barbanti, Marco, additional, D’Errigo, Paola, additional, Ranucci, Marco, additional, Onorati, Francesco, additional, Covello, Remo Daniel, additional, Santini, Francesco, additional, Rosato, Stefano, additional, Santoro, Gennaro, additional, Fusco, Danilo, additional, Grossi, Claudio, additional, and Seccareccia, Fulvia, additional

Published
2015
Full Text
View/download PDF

34. Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis Patients Undergoing Chronic Dialysis

Author

Ohno, Yohei, primary, Attizzani, Guilherme F., additional, Barbanti, Marco, additional, D’Errigo, Paola, additional, Grossi, Claudio, additional, Covello, Remo Daniel, additional, Onorati, Francesco, additional, Santini, Francesco, additional, Ranucci, Marco, additional, Rosato, Stefano, additional, Santoro, Gennaro, additional, Fusco, Danilo, additional, Tamburino, Corrado, additional, and Seccareccia, Fulvia, additional

Published
2015
Full Text
View/download PDF

35. Preliminary outcomes after transcatheter aortic valve implantation in patients with systemic sclerosis

Author

Bernelli, Chiara, primary, Chieffo, Alaide, additional, Giustino, Gennaro, additional, Montorfano, Matteo, additional, Latib, Azeem, additional, Panoulas, Vasileios F., additional, Covello, Remo Daniel, additional, Agricola, Eustachio, additional, Spagnolo, Pietro, additional, Alfieri, Ottavio, additional, Colombo, Antonio, additional, and Cioni, Micaela, additional

Published
2015
Full Text
View/download PDF

36. CRT-800 Transfemoral Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Aortic Stenosis at Intermediate Surgical Risk: 12-month Results: from the OBSERVANT Study

Author

D'Errigo, Paola, primary, Seccareccia, Fulvia, additional, Tamburino, Corrado, additional, Barbanti, Marco, additional, Ranucci, Marco, additional, Onorati, Francesco, additional, Covello, Remo Daniel, additional, Santini, Francesco, additional, Rosato, Stefano, additional, Santoro, Gennaro, additional, and Grossi, Caludio, additional

Published
2015
Full Text
View/download PDF

38. First case reported of transcatheter aortic valve implantation in a patient affected by Fabry’s Disease and severe low-flow low-gradient aortic valve stenosis

Author

Giustino, Gennaro, primary, Chieffo, Alaide, additional, Montorfano, Matteo, additional, Spagnolo, Pietro, additional, Panoulas, Vasileios F., additional, Bernelli, Chiara, additional, Latib, Azeem, additional, Agricola, Eustachio, additional, Covello, Remo Daniel, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional

Published
2014
Full Text
View/download PDF

39. Red blood cell distribution width predicts one-year mortality following transcatheter aortic valve implantation

Author

Magri, Caroline J., primary, Chieffo, Alaide, additional, Latib, Azeem, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Cioni, Michela, additional, Agricola, Eustachio, additional, Covello, Remo Daniel, additional, Gerli, Chiara, additional, Franco, Annalisa, additional, Spagnolo, Pietro, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional

Published
2014
Full Text
View/download PDF

40. Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis: Results from an intermediate risk propensity-matched population of the Italian OBSERVANT study

Author

D'Errigo, Paola, primary, Barbanti, Marco, additional, Ranucci, Marco, additional, Onorati, Francesco, additional, Covello, Remo Daniel, additional, Rosato, Stefano, additional, Tamburino, Corrado, additional, Santini, Francesco, additional, Santoro, Gennaro, additional, and Seccareccia, Fulvia, additional

Published
2013
Full Text
View/download PDF

41. A comparison of the femoral and radial crossover techniques for vascular access management in transcatheter aortic valve implantation: The milan experience

Author

Curran, Helen, primary, Chieffo, Alaide, additional, Buchanan, Gill Louise, additional, Bernelli, Chiara, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Latib, Azeem, additional, Maccagni, Davide, additional, Carlino, Mauro, additional, Figini, Filippo, additional, Cioni, Micaela, additional, Canna, Giovanni La, additional, Covello, Remo Daniel, additional, Franco, Annalisa, additional, Gerli, Chiara, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional

Published
2013
Full Text
View/download PDF

42. BLEEDING EVENTS AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION: USEFULNESS OF BASELINE ACTIVATED CLOTTING TIME IN GUIDING THE ANTITHROMBOTIC REGIMEN DURING TRANSCATHETER AORTIC VALVE IMPLANTATION PROCEDURES

Author

Bernelli, Chiara, primary, Chieffo, Alaide, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Latib, Azeem, additional, Carlino, Mauro, additional, Figini, Filippo, additional, Giannini, Francesco, additional, Buchanan, Gill Louise, additional, Covello, Remo Daniel, additional, Gerli, Chiara, additional, Annalisa, Franco, additional, Agricola, Eustachio, additional, Canna, Giovanni La, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional

Published
2013
Full Text
View/download PDF

43. Impact of Mean Platelet Volume on Combined Safety Endpoint and Vascular and Bleeding Complications following Percutaneous Transfemoral Transcatheter Aortic Valve Implantation

Author

Magri, Caroline J., primary, Chieffo, Alaide, additional, Durante, Alessandro, additional, Latib, Azeem, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Cioni, Michela, additional, Agricola, Eustachio, additional, Covello, Remo Daniel, additional, Gerli, Chiara, additional, Franco, Annalisa, additional, Spagnolo, Pietro, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional

Published
2013
Full Text
View/download PDF

44. A “modified crossover technique” for vascular access management in high-risk patients undergoing transfemoral transcatheter aortic valve implantation

Author

Buchanan, Gill Louise, primary, Chieffo, Alaide, additional, Montorfano, Matteo, additional, Maccagni, Davide, additional, Maisano, Francesco, additional, Latib, Azeem, additional, Covello, Remo Daniel, additional, Grimaldi, Antonio, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional

Published
2012
Full Text
View/download PDF

45. AS-124 Outcomes Following Transcatheter Aortic Valve Implantation Comparing Edwards SAPIEN™ XT And Medtronic CoreValve ReValving System® Devices: Results from the Milan Registry

Author

Buchanan, Gill Louise, primary, Chieffo, Alaide, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Latib, Azeem, additional, Figini, Filippo, additional, Cioni, Micaela, additional, Ferrarrello, Santo, additional, Carlino, Mauro, additional, Franco, Annalisa, additional, Gerli, Chiara, additional, Covello, Remo Daniel, additional, Grimaldi, Antonio, additional, La Canna, Giovanni, additional, Spagnolo, Pietro, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional

Published
2012
Full Text
View/download PDF

46. Transcatheter valve-in-valve implantation with the Edwards SAPIEN in patients with bioprosthetic heart valve failure: the Milan experience

Author

Latib, Azeem, primary, Ielasi, Alfonso, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Chieffo, Alaide, additional, Cioni, Micaela, additional, Mussardo, Marco, additional, Bertoldi, Letizia, additional, Shannon, Joanne, additional, Sacco, Francesco, additional, Covello, Remo Daniel, additional, Figini, Filippo, additional, Godino, Cosmo, additional, Grimaldi, Antonio, additional, Spagnolo, Pietro, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional

Published
2012
Full Text
View/download PDF

47. VARC OUTCOMES FOLLOWING TRANSCATHETER AORTIC VALVE IMPLANTATION WITH BOTH EDWARDS SAPIEN™ AND MEDTRONIC COREVALVE REVALVING SYSTEM® DEVICES: RESULTS FROM THE MILAN REGISTRY

Author

Buchanan, Gill Louise, primary, Chieffo, Alaide, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Latib, Azeem, additional, Cioni, Micaela, additional, Figini, Filippo, additional, Ferrarello, Santo, additional, Covello, Remo Daniel, additional, Franco, Annalisa, additional, Gerli, Chiara, additional, Grimaldi, Antonio, additional, Canna, Giovanni La, additional, Spagnolo, Pietro, additional, Carlino, Mauro, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional

Published
2012
Full Text
View/download PDF

48. OUTCOMES FOLLOWING TRANSCATHETER AORTIC VALVE IMPLANTATION COMPARING EDWARDS SAPIEN™ WITH MEDTRONIC COREVALVE REVALVING SYSTEM® DEVICES: RESULTS FROM THE MILAN REGISTRY

Author

Buchanan, Gill Louise, primary, Chieffo, Alaide, additional, Montorfano, Matteo, additional, Maisano, Francesco, additional, Latib, Azeem, additional, Figini, Filippo, additional, Cioni, Micaela, additional, Ferrarello, Santo, additional, Covello, Remo Daniel, additional, Franco, Annalisa, additional, Gerli, Chiara, additional, Spagnolo, Pietro, additional, Grimaldi, Antonio, additional, Canna, Giovanni La, additional, Carlino, Mauro, additional, Alfieri, Ottavio, additional, and Colombo, Antonio, additional

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results