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4 results on '"Couvyduchesne, Baptiste"'

1. Investigating the relationship between iron and depression

Author

Mills, Natalie T., Maier, Robert, Whitfield, John B., Wright, Margaret J., Colodro-Conde, Lucia, Byrne, Enda M., Scott, James G., Byrne, Gerard J., Hansell, Narelle K., Vinkhuyzen, Anna A.E., CouvyDuchesne, Baptiste, Montgomery, Grant W., Henders, Anjali K., Martin, Nicholas G., Wray, Naomi R., and Benyamin, Beben

Published
2017
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2. Shared and specific genetic risk factors for lifetime major depression, depressive symptoms and neuroticism in three population-based twin samples

Author

Kendler, Kenneth S., primary, Gardner, Charles O., additional, Neale, Michael C., additional, Aggen, Steve, additional, Heath, Andrew, additional, Colodro-Conde, Lucía, additional, Couvyduchesne, Baptiste, additional, Byrne, Enda M., additional, Martin, Nicholas G., additional, and Gillespie, Nathan A., additional

Published
2018
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3. Shared and specific genetic risk factors for lifetime major depression, depressive symptoms and neuroticism in three population-based twin samples.

Author

Kendler, Kenneth S., Gardner, Charles O., Neale, Michael C., Aggen, Steve, Heath, Andrew, Colodro-Conde, Lucía, Couvyduchesne, Baptiste, Byrne, Enda M., Martin, Nicholas G., and Gillespie, Nathan A.

Subjects
DIAGNOSIS of mental depression, MENTAL depression genetics, MENTAL depression risk factors, INTERVIEWING, PERSONALITY assessment, RISK assessment, SELF-evaluation, TWINS, STRUCTURAL equation modeling, ADULTS
Abstract

Background: Vulnerability to depression can be measured in different ways. We here examine how genetic risk factors are inter-related for lifetime major depression (MD), self-report current depressive symptoms and the personality trait Neuroticism. Method: We obtained data from three population-based adult twin samples (Virginia n = 4672, Australia #1 n = 3598 and Australia #2 n = 1878) to which we fitted a common factor model where risk for 'broadly defined depression' was indexed by (i) lifetime MD assessed at personal interview, (ii) depressive symptoms, and (iii) neuroticism. We examined the proportion of genetic risk for MD deriving from the common factor v. specific to MD in each sample and then analyzed them jointly. Structural equation modeling was conducted in Mx. Results: The best fit models in all samples included additive genetic and unique environmental effects. The proportion of genetic effects unique to lifetime MD and not shared with the broad depression common factor in the three samples were estimated as 77, 61, and 65%, respectively. A cross-sample mega-analysis model fit well and estimated that 65% of the genetic risk for MD was unique. Conclusion: A large proportion of genetic risk factors for lifetime MD was not, in the samples studied, captured by a common factor for broadly defined depression utilizing MD and self-report measures of current depressive symptoms and Neuroticism. The genetic substrate for MD may reflect neurobiological processes underlying the episodic nature of its cognitive, motor and neurovegetative manifestations, which are not well indexed by current depressive symptom and neuroticism. [ABSTRACT FROM AUTHOR]

Published
2019
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4. Investigating the relationship between iron and depression

Author

Gerard J. Byrne, Enda M. Byrne, Natalie T. Mills, Lucía Colodro-Conde, James Scott, Naomi R. Wray, Margaret J. Wright, Anjali K. Henders, Beben Benyamin, Narelle K. Hansell, Anna A. E. Vinkhuyzen, Grant W. Montgomery, Nicholas G. Martin, Baptiste Couvy-Duchesne, Robert Maier, John Whitfield, Mills, Natalie T, Maier, Robert, Whitfield, John B, Wright, Margaret J, Colodro-Conde, Lucia, Byrne, Enda M, Scott, James G, Byrne, Gerard J, Hansell, Narelle K, Vinkhuyzen, Anna AE, CouvyDuchesne, Baptiste, Montgomery, Grant W, Henders, Anjali K, Martin, Nicholas G, Wray, Naomi R, and Benyamin, Beben

Subjects
0301 basic medicine, Adult, Male, medicine.medical_specialty, Adolescent, Iron, Poison control, Linkage Disequilibrium, 03 medical and health sciences, Young Adult, 0302 clinical medicine, iron, transferrin saturation, medicine, Humans, transferrin, Genetic Predisposition to Disease, Registries, Psychiatry, Biological Psychiatry, Genetic association, chemistry.chemical_classification, Depressive Disorder, Major, biology, medicine.diagnostic_test, Transferrin saturation, ferritin, Australia, Transferrin, medicine.disease, Ferritin, Psychiatry and Mental health, 030104 developmental biology, chemistry, Cohort, depression, Ferritins, biology.protein, Serum iron, Major depressive disorder, Female, Queensland, Psychology, 030217 neurology & neurosurgery, Demography, Genome-Wide Association Study
Abstract

Lower levels of circulating iron have been associated with depression. Our objective was to investigate the phenotypic and genetic relationship between measures of circulating levels of iron (serum iron, transferrin, transferrin saturation, and ferritin) and depressive symptoms. Data were available from ongoing studies at QIMR Berghofer Medical Research Institute (QIMRB), including twin adolescents (mean age 15.1 years, standard deviation (SD) 3.2 years), and twin adults (mean age 23.2 years, SD 2.2 years). In the adolescent cohort, there were 3416 participants from 1688 families. In the adult cohort there were 9035 participants from 4533 families. We estimated heritabilities of, and phenotypic and genetic correlations between, traits. We conducted analyses that linked results from published large-scale genome-wide association studies (including iron and Major Depressive Disorder) with our study samples using single SNP and multi-SNP genetic risk score analyses, and LD score regression analyses. In both cohorts, measures of iron, transferrin, transferrin saturation, and log 10 of ferritin (L10Fer) were all highly heritable, while depressive measures were moderately heritable. In adolescents, depression measures were higher in those in the middle 10th versus top 10th percentile of transferrin saturation measures (p = 0.002). Genetic profile risk scores of the iron measures were not significantly associated with depression in study participants. LD score analyses showed no significant genetic relationship between iron and depression. Genetic factors strongly influence iron measures in adolescents and adults. Using several different strategies we find no evidence for a genetic contribution to the relationship between blood measures of iron and measures of depression. Refereed/Peer-reviewed

Published
2017

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