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6. A randomized cross over trial of tolerability and compliance of a micronutrient supplement with low iron separated from calcium vs high iron combined with calcium in pregnant women [ISRCTN56071145]

Author

Couturier Bernard, Cérat Yves, Pairaudeau Nicholas, Ahn Eric, Fortier Andre, Paradis Éric, and Koren Gideon

Subjects
Gynecology and obstetrics, RG1-991
Abstract

Abstract Background Prenatal micronutrient combinations with high iron content are associated with high rates of gastrointestinal symptoms. This coupled with nausea and vomiting of pregnancy results in women often discontinuing their multivitamins. A new prescription supplement (PregVit®) that separates iron from calcium in two tablets – morning and evening, has lower elemental iron content (35 mg), but results in similar extent of iron absorption when compared to another supplement containing (60 mg) of elemental iron (Materna®). The objectives of this study were to compare tolerability and compliance with PregVit® vs. a supplement with high iron content (Materna®), in pregnant women. Methods Randomized, crossover open labeled study in 135 pregnant women attending outpatient clinics in Ontario and Quebec. Results Use of PregVit® was associated with a 30% reduction in constipation rate as compared to Materna®. Both products demonstrated similar compliance rates. Compliance of Materna® was negatively associated with the severity of nausea and vomiting of pregnancy. No such correlation was found for PregVvit®. Conclusion PregVit®, a supplement with lower iron content (35 mg), has significantly decreased constipation rates as compared to 60 mg iron- Materna and has similar compliance rates. High iron content in multivitamin supplements is associated with adverse effects in pregnancy.

Published
2006
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7. Conjugating Phosphospermines to siRNAs for Improved Stability in Serum, Intracellular Delivery and RNAi-Mediated Gene Silencing

Author

Paris, Clément, primary, Moreau, Valérie, additional, Deglane, Gaëlle, additional, Karim, Loukmane, additional, Couturier, Bernard, additional, Bonnet, Marie-Elise, additional, Kedinger, Valérie, additional, Messmer, Mélanie, additional, Bolcato-Bellemin, Anne-Laure, additional, Behr, Jean-Paul, additional, Erbacher, Patrick, additional, and Lenne-Samuel, Nathalie, additional

Published
2012
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15. Géologie des barrages collinaires

Author

Couturier Bernard

Subjects
Geography, Nature Conservation, Geology, Geotechnical Engineering and Engineering Geology, Humanities
Abstract

Si l'intervention du geologue dans l'etude des grands barrages est systematique en France depuis plusieurs decennies, sa participation aux etudes de barrages collinaires l'a ete beaucoup moins.

Published
1985
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16. Contribution à l'étude géologique, hydrogéologique et géotechnique du bas Grésivaudan (Isère) - Alpes françaises

Author

Couturier, Bernard, Institut de géologie Dolomieu, Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Université Scientifique et Médicale de Grenoble, and Reynold Barbier

Subjects
hydrogéologie, Grésivaudan, Isère, piézométrie de la nappe alluviale, morphologie, risques naturels, prospection géophysique, bed-rock, géotechnique, vallée alluviale, [SDU.STU.HY]Sciences of the Universe [physics]/Earth Sciences/Hydrology
Abstract

Ce travail finalisé en 1975 apporte une contribution synthétique à l'hydrogéologie et à la géotechnique de la vallée de l'Isère au NE de Grenoble.; pas de résumé

Published
1974

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