25 results on '"Couto-Souza PH"'
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2. Recent infective endocarditis research findings suggest dentists prescribe prophylactic antibiotics for patients having a bicuspid aortic valve or mitral valve prolapse.
- Author
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Friedlander AH and Couto-Souza PH
- Subjects
- Humans, Anti-Bacterial Agents therapeutic use, Dentists, Mitral Valve Prolapse complications, Mitral Valve Prolapse drug therapy, Mitral Valve Prolapse epidemiology, Bicuspid Aortic Valve Disease complications, Bicuspid Aortic Valve Disease drug therapy, Endocarditis prevention & control, Endocarditis complications, Endocarditis drug therapy, Endocarditis, Bacterial prevention & control, Endocarditis, Bacterial complications, Endocarditis, Bacterial drug therapy
- Abstract
Background: The scientific validity of the European Society of Cardiology's (ESC) infective endocarditis (IE) guidelines limiting provision of prophylactic antibiotics (AP) only to patients having cardiac anomalies (e.g., prosthetic valves) believed to place them at "high risk" of adverse events when undergoing high risk dental procedures (HRDP) is unclear., Material and Methods: A systematic review of studies conducted between 2017 and 2022 and catalogued in the PubMed database was undertaken to ascertain if this edict was associated with changes in IE incidence, development of infection in unprotected cardiac anomalies, developing infection and resultant adverse clinical outcomes., Results: Retrieved were 19 published manuscripts, however of these, 16 were excluded because they did not bare upon the issues of concern. Among the three studies eligible for review were those in the Netherlands, Spain, and England. The results of the Dutch study denoted a significant increase in the incidence of IE cases over the projected historical trend (rate ratio: 1327, 95% CI 1.205-1.462; p<0.001) after the introduction of the ESC guidelines. The findings from the Spanish study evidenced the uniquely high in-hospital IE associated fatality rates suffered by patients having bicuspid aortic valves (BAV); 5.6% or mitral valve prolapse (MVP); 10%. The British study provided evidence that the incidence of fatal IE infection was significantly greater among an "intermediate risk" cohort of patients, (a group likely including those with BAC and MVP for which the ESC guidelines don't recommend AP), than among "high risk" patients (P = 0.002)., Conclusions: Patients having either a BAV or MVP are at significant risk of developing IE and suffering serious sequelae including death. The ESC guidelines must reclassify these specific cardiac anomalies into the "high risk" category so that AP are recognized as being needed prior to provision of HRDP.
- Published
- 2023
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3. Periodontitis in individuals with few remaining teeth and a high gingival bleeding index increases the probability of dyslipidemia.
- Author
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Gomes-Filho IS, Freitas TOB, Cruz SSD, Trindade SC, Figueiredo ACMG, Couto Souza PH, Cerqueira EMM, Hintz AM, Carneiro DO, Lacerda JA, Seymour GJ, Scannapieco FA, Loomer PM, and Passos-Soares JS
- Subjects
- Humans, Adolescent, Cross-Sectional Studies, Probability, Dental Caries, Periodontitis complications, Periodontitis epidemiology, Mouth Diseases
- Abstract
Background: Dyslipidemia, a silent multifactorial condition, is characterized by changes in blood lipid levels, affecting all socioeconomic strata, increasing the risk for atherosclerotic diseases. This study investigated whether there is an association between dyslipidemia and the combined exposure of periodontitis plus the number of remaining teeth, gingival bleeding, or caries., Methods: A two-center cross-sectional study was conducted involving 1270 individuals, with a minimum age of 18 years. Socioeconomic and demographic data, health conditions, lifestyle parameters, and anthropometric, biochemical, and oral clinical examinations were performed. The exposures considered were the presence of periodontitis, dental caries, number of remaining teeth, and gingival bleeding. The outcome was dyslipidemia as defined by the Brazilian Guidelines on Dyslipidemia and Prevention of Atherosclerosis. The combined associations between periodontitis plus other oral health conditions and dyslipidemia were estimated using confounder-adjusted prevalence ratios (PR
single , PRmultiple , for single and multiple covariable adjustments) with 95% confidence intervals (95% CIs), in a Poisson regression model with robust variance., Results: The occurrence of dyslipidemia was 70.1% and periodontitis was 84.1%. A positive association between periodontitis and dyslipidemia existed: PRsingle = 1.13; 95% CI: 1.01-1.26. Combined exposure of periodontitis plus <11 remaining teeth (PRmultiple = 1.23; 95% CI: 1.05-1.43), as well as combined exposure of periodontitis plus ≥10% gingival bleeding and <11 remaining teeth (PRmultiple = 1.22; 95% CI: 1.03-1.44), represented greater probabilities of 23% and 22% of individuals having a diagnosis of dyslipidemia., Conclusion: Periodontitis combined with fewer than 11 teeth doubled the likelihood of being diagnosed with dyslipidemia., (© 2023 American Academy of Periodontology.)- Published
- 2023
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4. Immunohistochemical detection of NANOG in oral leukoplakia.
- Author
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Kitahara ABP, Michels AC, Luiz ST, Nagashima S, Camargo Martins AP, de Azevedo MLV, Azevedo Alanis LR, Couto Souza PH, Ignácio SA, de Noronha L, Bettega PVC, Tyski MCA, Quispe EMP, Mozzer I, Souto GR, Aguiar MCF, Modolo F, Scariot R, Jham BC, Hardy AMTG, and Johann ACBR
- Subjects
- Humans, Nanog Homeobox Protein, Leukoplakia, Oral diagnosis, Mouth Neoplasms diagnosis
- Published
- 2023
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5. Maxillofacial Surgeons Beware: Some American Heart Association "Moderate Risk" Patients Develop Endocarditis After Exodontia.
- Author
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Friedlander AH and Couto-Souza PH
- Subjects
- United States, Humans, Oral and Maxillofacial Surgeons, Anti-Bacterial Agents therapeutic use, Tooth Extraction, American Heart Association, Endocarditis etiology, Endocarditis drug therapy
- Published
- 2023
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6. American Heart Association "Moderate-Risk" Patients Develop Infectious Endocarditis After Dental Extractions.
- Author
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Friedlander AH and Couto-Souza PH
- Subjects
- Humans, American Heart Association, Anti-Bacterial Agents therapeutic use, Tooth Extraction adverse effects, Antibiotic Prophylaxis, Endocarditis, Bacterial diagnosis, Endocarditis, Bacterial etiology, Endocarditis, Bacterial drug therapy, Endocarditis diagnosis, Endocarditis etiology, Endocarditis drug therapy
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- 2023
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7. Periodontitis is a factor associated with dyslipidemia.
- Author
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Gomes-Filho IS, Oliveira MT, Cruz SSD, Cerqueira EMM, Trindade SC, Vieira GO, Couto Souza PH, Adan LFF, Hintz AM, Passos-Soares JS, Scannapieco FA, Loomer PM, Seymour GJ, and Figueiredo ACMG
- Subjects
- Cross-Sectional Studies, Humans, Risk Factors, Waist Circumference, Dyslipidemias complications, Dyslipidemias epidemiology, Periodontitis complications
- Abstract
Objective: To investigate the association between the severity of periodontitis (exposure) and dyslipidemia (outcome)., Methods: This was a cross-sectional study of users of public health services. Periodontitis was defined using the Center for Disease Prevention and Control and the American Academy of Periodontology criteria. Lipid evaluation used data on systemic biomarkers. Dyslipidemia diagnosis was based on the Guidelines of total cardiovascular risk of the World Health Organization. Weight, height, waist circumference, and blood pressure were measured, and socioeconomic-demographic, lifestyle behavior factors, general and oral health conditions of the participants were collected. Hierarchical and logistic regression analyzes were used to determine the association between the exposures and the outcome. Odds Ratios, unadjusted and adjusted, and 95% confidence intervals were estimated., Results: Of 1,011 individuals examined, 75.17% had dyslipidemia, and 84.17% had periodontitis, 0.2% with mild, 48.56% moderate, and 35.41% severe disease. The association between periodontitis and dyslipidemia was maintained through hierarchical analysis and in the multiple regression modeling, showing that the occurrences of dyslipidemia in the group with periodontitis, and its moderate and severe levels, were, respectively, 14%, 30%, and 16% higher compared with those without periodontitis., Conclusions: The results showed a positive association between moderate and severe periodontitis and dyslipidemia., (© 2021 Wiley Periodicals LLC.)
- Published
- 2022
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8. Panoramic imaged carotid atheromas are associated with increased neutrophil count: both validated, independent predictors of near-term myocardial infarction.
- Author
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Chang TI, Wu X, Boström KI, Tran HA, Couto-Souza PH, and Friedlander AH
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- Aged, Aged, 80 and over, Carotid Arteries, Humans, Male, Neutrophils, Radiography, Panoramic, Retrospective Studies, Risk Factors, Carotid Artery Diseases diagnostic imaging, Myocardial Infarction diagnostic imaging, Plaque, Atherosclerotic
- Abstract
Objectives: Panoramic images (PXs) demonstrating calcified carotid artery atheromas (CCAAs) are associated with heightened risk of near-term myocardial infarction (MI). Elevated neutrophil counts (NC) within normal range 2,500-6,000 per mm
3 are likewise associated with future MI signaling the role neutrophils play in the chronic inflammation process underlying coronary artery atherogenesis. We determined if CCAAs on PXs are associated with increased NC., Methods: Investigators implemented a retrospective study of PXs and accompanying medical records of white males ≥ 65 years treated by a VA dental service. Two groups ( N = 60 each) were constituted, one with atheromas (CCAA+) and one without (CCAA-). Predictor variable was CCAA + and outcome variable was NC. Bootstrapping analysis determined the difference in mean NCs between two groups, significance set at ≤0.05., Results: The study group of (CCAA+) (mean age 75.9; range 69-91 years) demonstrated a mean NC of 4,843 per mm3 and control group (CCAA-) (mean age 75.3; range; 66-94) a mean NC of 4,108 per mm3 . The difference between the groups was significant ( p = 0.0008) (95% CI of difference of mean: -432, 431; observed effect size 736)., Conclusions: CCAAs on PXs of elderly white males are associated with elevated NC; amplifying need for medical consultation prior to invasive dental procedures.- Published
- 2021
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9. Association of xerostomia and taste alterations of patients receiving antineoplastic chemotherapy: A cause for nutritional concern.
- Author
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Silva IMV, Donaduzzi LC, Perini CC, Couto SAB, Werneck RI, de Araújo MR, Kurahashi M, Johann ACBR, Azevedo-Alanis LR, Vieira AR, and Couto-Souza PH
- Subjects
- Dysgeusia chemically induced, Dysgeusia epidemiology, Female, Humans, Male, Middle Aged, Quality of Life, Taste, Antineoplastic Agents adverse effects, Xerostomia chemically induced, Xerostomia epidemiology
- Abstract
Background & Aims: The symptoms of xerostomia and taste alteration are adverse effects which frequently occur in patients under chemotherapy and once associated they can potentially impair their nutritional status. The aim of this study was to investigate the association of xerostomia and taste alterations in patients being treated by neoplastic chemotherapy., Methods: Fifty patients scheduled to receive neoplastic chemotherapy were followed for their first two chemotherapy cycles for solid tumors and the Chemotherapy-Induced Taste Alteration Scale (CiTAS) was adopted. Xerostomia was defined by the presence of dry mouth complaints reported by the patients and signs of hyposalivation identified during the intraoral examination., Results: Of the 50 patients, 33 were women, mean age; 61,48 ± 9,07 years, and 17 were men, mean age; 57,35 ± 11,50 years. The most common tumor was located in the breast affecting 15 patients (30%). The Mann-Whitney test showed that the mean scores of CiTAS were significantly higher for those patients who reported having xerostomia when compared with those without xerostomia after the first two chemotherapy cycles. The cofounding variables such as age, smoking habits and use of antidepressants were not statistically associated with taste alterations (p > 0.05)., Conclusions: Taste alterations were worse for patients who complained of xerostomia during the first two cycles of antineoplastic chemotherapy and the association of both symptoms can potentially impair their nutritional status and quality of life., Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest., (Copyright © 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2021
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10. Surgeons Beware: Some Red Heads Have Increased Requirements for Inhalation, Infiltration, and Topically Administered Anesthetic Agents.
- Author
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Friedlander AH, Couto-Souza PH, and Berti-Couto SA
- Subjects
- Humans, Anesthetics, Inhalation, Surgeons
- Published
- 2021
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11. Inflammatory cytologic alterations in the oral epithelium associated with HIV pre-exposure prophylaxis: a preliminary study.
- Author
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Baggio GL, Macedo NF, Merlin JC, Anghebem MI, Santos JCV, Ignácio SA, Rubira-Bullen IRF, Azevedo Alanis LR, and Couto Souza PH
- Subjects
- Epithelial Cells, Epithelium, Humans, HIV Infections prevention & control, Mouth Mucosa
- Abstract
Objective: The objective of this study was to assess inflammatory cytologic alterations in the oral epithelium of patients on human immunodeficiency virus pre-exposure prophylaxis (PrEP)., Material and Methods: Epithelial cells from the buccal mucosa of 30 patients were collected by exfoliative cytology and were evaluated according to inflammatory cellular alterations: karyomegaly, bi- or multinucleation, karyopyknosis, karyorrhexis, perinuclear halo formation, metachromasia, cytoplasmic vacuolization, indistinct cytoplasmic border, keratinization, and atrophy. Epithelial cells were collected initially before PrEP onset (T1) and then after 30 days of PrEP use (T2). Two experienced cytopathologists independently analyzed the slides., Results: The nonparametric Wilcoxon test showed that there was a statistically significant increase in the number of cells with karyomegaly at T2 compared to T1 (P = .033). The other cellular alterations did not present with statistically significant differences between the 2 moments of evaluation (P > .05)., Conclusion: The increased number of oral epithelial cells with karyomegaly after 30 days of using PrEP suggests the presence of inflammatory alterations at this site., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
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12. Elevated White Blood Cell Count Resultant Atherogenesis is Associated With Panoramic-Imaged Carotid Plaque.
- Author
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Chang TI, Wu X, Boström KI, Tran HA, Couto-Souza PH, and Friedlander AH
- Subjects
- Aged, Aged, 80 and over, Endothelial Cells, Humans, Leukocyte Count, Male, Middle Aged, Radiography, Panoramic, Retrospective Studies, Risk Factors, Atherosclerosis, Carotid Artery Diseases, Plaque, Atherosclerotic
- Abstract
Purpose: Atherosclerotic plaques develop as a result of a low-grade, chronic, systemic inflammatory response to the injury of endothelial cells arising from lipid deposition within the intima. Increased white blood cell count (WBCC) is both a validated "biologic marker" of the extent of this inflammatory process and a key participant in the development of subsequent atherosclerotic ischemic heart disease manifesting as myocardial infarction. We sought to determine if calcified carotid artery plaque (CCAP) on a panoramic image (PI), also a validated risk indicator of future myocardial infarction, is associated with increased WBCC., Patients and Methods: We retrospectively evaluated the PI and medical records of White male military veterans aged 55 years and older treated by a VA dental service. Established were 2 cohorts of patients, 50 having plaques (CCAP+) and 50 without plaques (CCAP-). Predictor variable was CCAP+; outcome variable was WBCC. Bootstrapping analysis determined the differences in mean WBCCs between groups. Statistical significance set at ≤ 0.05., Results: The study group, (mean age 74; range 59 to 91 years) demonstrated a mean WBCC of 8,062 per mm
3 . The control group, (mean age 72 range; 57 to 94) evidenced a mean WBCC of 7,058 per mm3 . Bootstrapping analysis of WBCC values demonstrated a significant (P = .012) difference (95% confidence interval of difference of mean, -806, 742; observed effect size, 1004) between groups., Conclusions: The presence of CCAP demonstrated on PIs of older Caucasian men is associated with elevated WBCC. Concomitant presence of CCAP on PI and increased WBCC (≥7,800 per mm3 ) amplifies need for medical consultation before intravenous anesthesia and maxillofacial surgical procedures., (Published by Elsevier Inc.)- Published
- 2021
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13. Late Oral Complications Caused by Head and Neck Radiotherapy: Clinical and Laboratory Study.
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Martinez AC, Silva IMV, Berti Couto SA, Gandra RF, Rosa EAR, Johann ACBR, and Couto Souza PH
- Abstract
Objectives: The aim of presented cross-sectional and observational study was to determine the prevalence of late oral complications of patients with head and neck cancer who underwent radiotherapy, by clinical and laboratory analyses., Material and Methods: Fifty-five patients, 43 (78.2%) men and 12 (21.8%) women, mean age 60; range 38 to 87 years, who have completed radiotherapy for head and neck cancer for at least 6 months were enrolled. The presence of xerostomia, hyposalivation, oral candidiasis, and type of oral yeasts were correlated with post-radiotherapy period. A control group, age and gender matched, was used for comparisons. The Pearson's Chi-square or Fischer's exact test was used at a significance level of 5%., Results: The mean post-radiotherapy period was 32 months. The oral complications found were xerostomia (45/55, [81.8%]), hyposalivation (44/55 [80%]) and oral candidiasis (15/55 [27.2%]). Xerostomia and hyposalivation was statistically higher in the study group when compared to the control group (P < 0.05). The presence of yeast occurred in 39 (70.9%) of the patients in the study group, and Candida albicans was the most prevalent etiological agent in 25 (64.1%) of those patients (P < 0.05)., Conclusions: Xerostomia and hyposalivation were the more prevalent late oral complications related to radiotherapy. Oral candidiasis was also observed, although its prevalence was lower. The need for long-term dental follow-up of patients who underwent radiotherapy of the head and neck cancer is mandatory., (Copyright © Martinez AC, Silva IMV, Berti Couto SA, Gandra RF, Rosa EAR, Johann ACBR, Couto Souza PH. Published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH (http://www.ejomr.org), 30 September 2020.)
- Published
- 2020
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14. Surgeons Beware: The Preauricular Crease Is an Indicator of Coronary Artery Atherosclerosis as well as an Anatomic Landmark.
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Friedlander AH, Couto-Souza PH, and Berti-Couto SA
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- Anatomic Landmarks, Coronary Vessels, Ear, External, Humans, Atherosclerosis diagnosis, Coronary Artery Disease diagnosis, Surgeons
- Published
- 2020
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15. Salivary protein candidates for biomarkers of oral disorders in alcohol and tobacco dependents.
- Author
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Penteado CAS, Batista TBD, Chaiben CL, Bonacin BG, Ventura TMO, Dionizio A, Couto Souza PH, Buzalaf MAR, and Azevedo-Alanis LR
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Objectives: To evaluate the oral condition of alcohol and tobacco dependents and identify salivary protein candidates for biomarkers of oral disorders., Subjects and Methods: Thirty-three male volunteers were evaluated for alcohol abuse rehabilitation; nine were selected for proteomic analysis. Intraoral examination was performed, and non-stimulated saliva was collected. Salivary proteins were extracted and processed for analysis. A list of proteins identified in saliva was generated from the database and manually revised, obtaining the total number of candidate biomarkers for oral disorders., Results: The mean age (n = 33) was 42.94 ± 8.61 years. Fourteen (42.4%) subjects presented with 23 oral mucosa changes, and 31 (94%) had dental plaque. A total of 282 proteins were found in saliva (n = 9), of which 26 were identified as candidates for biomarkers of oral disorders. After manual review, 21 proteins were selected. The highest number of candidates for biomarkers was associated with carcinoma of head and neck (n = 10), nasopharyngeal carcinoma (n = 6), and periodontal disease (n = 6)., Conclusion: Alcohol and tobacco dependents showed gingival inflammation, and less than half of them showed oral mucosa changes. Twenty-one protein candidates for biomarkers of oral disorders were identified in saliva. The two major oral disorders in number of candidates for biomarkers were head and neck cancer and periodontal disease., (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.)
- Published
- 2020
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16. Association of calcified carotid artery plaque in panoramic images and diagonal earlobe crease.
- Author
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Couto Souza PH, Berti-Couto SA, Majewski CNM, da Silva IC, Donaduzzi LC, Silva IMV, Lisboa MDC, Lee UK, Friedlander IK, and Friedlander AH
- Subjects
- Aged, Cross-Sectional Studies, Humans, Male, Middle Aged, Prevalence, Risk Factors, Carotid Artery Diseases diagnostic imaging, Carotid Stenosis diagnostic imaging, Plaque, Atherosclerotic diagnostic imaging, Radiography, Panoramic
- Abstract
Objectives:: Brazilians who are free of traditional atherogenic risk factors frequently suffer myocardial infarctions (MI). Calcified carotid artery plaque (CCAP) on panoramic images (PIs) has been shown to be a validated "risk indicator" of future MIs. The diagonal earlobe crease (DELC) is likewise a validated "risk indicator" of future MI. We sought to determine the prevalence of DELC+ among patients having CCAP+ on their PIs., Methods:: In a masked cross-sectional study, three dentists evaluated PIs of patients (N = 481) over age 55 for presence of CCAP+. Among the CCAP+ cohort, the presence of DELC+ was determined by two additional dentists masked to the presence of CCAP+ on PIs. A control group (CCAP-) comprised of individuals with PIs devoid of plaque was similarly evaluated for evidence of DELC+., Results:: A mixed-gender group (8.6%) of patients (N = 41; mean age 67.5 ± 6.8) evidenced CCAP+ on their PIs and approximately 88% of these individuals (N = 36) had concomitant DELC+. Among members of the control group (N = 41), 17 patients were DELC+. Our results demonstrated that among the full mixed-gender cohort (N = 82), the association between CCAP+ and DELC+ was statistically significant (p = 0.0001). However, when adjusting for gender, only the CCAP+ men were significantly (p = 0.00011) more likely to evidence DELC+ on clinical examination., Conclusions:: Males with atherosclerosis of their carotid arteries as evidenced by PIs displaying calcified atheromas are significantly more likely to evidence a DELC+ than those without an imaged atheroma.
- Published
- 2019
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17. Marsupialization of a Large Radicular Cyst with Extensive Maxillary Tooth Displacement: Eight-Year Follow-Up.
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Tanaka OM, Meira TM, Batista Rodrigues AC, Willems G, Baggio GL, and Couto Souza PH
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- Bicuspid, Child, Follow-Up Studies, Humans, Male, Tooth Movement Techniques, Tooth, Deciduous, Malocclusion etiology, Malocclusion therapy, Radicular Cyst complications, Radicular Cyst therapy
- Abstract
Radicular cysts arising from primary teeth are uncommon and, when present as large lesions, may adversely affect the underlying permanent teeth. The purpose of this paper is to describe the management of a very large atypical radicular cyst involving the primary dentition of a nine-year-old boy and causing extensive tooth displacement with transposition of the permanent maxillary left canine between the bicuspids. The root apex of the canine was close to the median level of the lateral border of the nasal cavity and showed incomplete root formation and signs of dilacerations in its apical third. Marsupialization was successfully performed, followed by long-term orthodontic treatment. This interdisciplinary management facilitated the lesion resolution for repositioning of the canine into functional occlusion. (J Dent Child 2019;86(1):64-8)
Received October 23, 2018; Last Revision January 10, 2019; Accepted January 11, 2019.- Published
- 2019
18. Three-dimensional validation of the impact of the quantity of teeth or tooth parts on the morphological difference between twin dentitions.
- Author
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Franco A, Willems G, Couto Souza PH, Coucke W, and Thevissen P
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- Bites, Human, Forensic Dentistry, Humans, Dentition, Imaging, Three-Dimensional, Models, Dental, Twins
- Abstract
Background: The number of teeth involved in cases of bite-mark analysis is generally fewer in comparison to the number of teeth available for cases of dental identification. This decreases the amount of information available and can hamper the distinction between bite suspects. The opposite is true in cases of dental identification and the assumption is that more teeth contribute to a higher degree of specificity and the possibility of identification in these cases. Despite being broadly accepted in forensic dentistry, this hypothesis has never been scientifically tested., Objective: The present study aims to assess the impact of the quantity of teeth or tooth parts on morphological differences in twin dentitions., Material and Methods: A sample of 344 dental casts collected from 86 pairs of twins was used. The dental casts were digitized using an automated motion device (XCAD 3D® (XCADCAM Technology®, São Paulo, SP, Brazil) and were imported as three-dimensional dental model images (3D-DMI) in Geomagic Studio® (3D Systems®, Rock Hill, SC, USA) software package. Sub samples were established based on the quantity of teeth and tooth parts studied. Pair wise morphological comparisons between the corresponding twin siblings were established and quantified., Results: Increasing the quantity of teeth and tooth parts resulted in an increase of morphological difference between twin dentitions. More evident differences were observed comparing anterior vs. entire dentitions (p < 0.05) and complete vs. partial anterior dentitions (p < 0.05)., Conclusion: Dental identifications and bite-mark analysis must include all the possibly related dental information to reach optimal comparison outcomes.
- Published
- 2016
19. Spontaneous Resolution of a Central Giant Cell Granuloma in a Child After an Incisional Biopsy: A Five-year Follow-up.
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Franco A, Segato AV, Couto SA, Rodrigues Johann AC, Friedlander AH, and Couto Souza PH
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- Adolescent, Biopsy, Diagnosis, Differential, Follow-Up Studies, Humans, Male, Granuloma, Giant Cell diagnostic imaging, Granuloma, Giant Cell pathology, Mandibular Diseases diagnostic imaging, Mandibular Diseases pathology
- Abstract
A central giant cell granuloma (CGCG) is typically regarded as a benign lesion with osteoclastic activity. Treatment often involves surgical procedures that may cause deformities; however, minimally invasive approaches have been suggested for treating pediatric patients. We report a case of CGCG of the mandible in a 13-year-old boy who presented with a well-defined radiolucent area in the anterior mandible that was initially detected in a radiographic examination for orthodontic purposes. An incisional biopsy was performed and diagnosed histologically as a CGCG. The patient underwent clinical and radiographic follow-up only after the biopsy, eventually showing signs of bone healing. Five years later, complete resolution of the lesion was observed radiographically. Considering this optimal outcome, similar cases of CGCG should be carefully analyzed for appropriateness of this conservative approach.
- Published
- 2016
20. Massive Submandibular Sialolith: Complete Radiographic Registration and Biochemical Analysis through X-Ray Diffraction.
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Franco A, de Carvalho Mattos MJ, Ferrari F, Dos Reis Neto JM, Carta Gambus LC, Couto Souza PH, and Berti-Couto Sde A
- Abstract
Sialolithiasis is a pathologic condition that affects 60 million people per year, which is caused by the presence of calcified structures, named sialoliths, inside the salivary glands and their salivary ducts. Despite the large incidence of sialolithiasis, its etiology is still unknown. In the present case report, a 47-year-old female patient, presenting with local pain and hampered mouth opening, underwent a surgical approach for the removal of a 20 mm sialolith, which was further analyzed through X-ray diffraction. In parallel, a radiographic registration of 8 years, covering all the period for sialolith formation, is presented along the case report.
- Published
- 2014
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21. Gingival Anaplastic Large-Cell Lymphoma Mimicking Hyperplastic Benignancy as the First Clinical Manifestation of AIDS: A Case Report and Review of the Literature.
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Rozza-de-Menezes RE, Jeronimo Ferreira S, Lenzi Capella D, Schwartz S, Willrich AH, de Noronha L, Batista Rodrigues Johann AC, and Couto Souza PH
- Abstract
This paper presents an unusual case of gingival ALCL, which mimicked a benign hyperplastic lesion that occurred in a 57-year-old white man representing the first clinical manifestation of acquired immunodeficiency syndrome (AIDS). The patient was referred to the Dental Clinic of PUCPR complaining of a lobulated nodule on the gingiva of his upper central incisors. The presence of advanced chronic periodontitis and dental plaque raised suspicion for a benignancy. An excisional biopsy was performed, and large pleomorphic cells with an abundant cytoplasm, sometimes containing prominent nucleoli and "Hallmark" cells, were observed through hematoxylin and eosin staining. The tumor cells showed strong CD30 expression, EMA, Ki-67, and LCA, and negative stain for p80(NPM/ALK), CKAE1/AE3, CD20, CD3, CD56, and CD15. The final diagnosis was ALCL (ALK-negative). Further laboratory tests revealed positivity for human immunodeficiency virus (HIV). The patient was submitted to chemotherapy, but four months after diagnosis, the patient died due to pneumonia and respiratory failure. Oral anaplastic large-cell lymphoma (ALCL) is a rare disorder. Only 5 cases involving the gingiva have been reported, and to our knowledge, this is the first case reported of the ALCL, which mimicked a hyperplastic benignancy as the first clinical manifestation of AIDS.
- Published
- 2013
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22. Clinical diagnosis of hyposalivation in hospitalized patients.
- Author
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Berti-Couto Sde A, Couto-Souza PH, Jacobs R, Nackaerts O, Rubira-Bullen IR, Westphalen FH, Moysés SJ, Ignácio SA, Costa MB, and Tolazzi AL
- Subjects
- Adult, Aged, Aged, 80 and over, Cheek, Chi-Square Distribution, Female, Humans, Male, Medical History Taking, Middle Aged, Predictive Value of Tests, Saliva metabolism, Xerostomia physiopathology, Hospitalization, Xerostomia diagnosis
- Abstract
Objective: The aim of this study was to evaluate the effectiveness of clinical criteria for the diagnosis of hyposalivation in hospitalized patients., Material and Methods: A clinical study was carried out on 145 subjects (48 males; 97 females; aged 20 to 90 years). Each subject was clinically examined, in the morning and in the afternoon, along 1 day. A focused anamnesis allowed identifying symptoms of hyposalivation, like xerostomia complaints (considered as a reference symptom), chewing difficulty, dysphagia and increased frequency of liquid intake. Afterwards, dryness of the mucosa of the cheeks and floor of the mouth, as well as salivary secretion during parotid gland stimulation were assessed during oral examination., Results: Results obtained with Chi-square tests showed that 71 patients (48.9%) presented xerostomia complaints, with a significant correlation with all hyposalivation symptoms (p <0.05). Furthermore, xerostomia was also significantly correlated with all data obtained during oral examination in both periods of evaluation (p<0.05)., Conclusion: Clinical diagnosis of hyposalivation in hospitalized patients is feasible and can provide an immediate and appropriate therapy avoiding further problems and improving their quality of life.
- Published
- 2012
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23. Histological diagnosis of oral lesions with cutting needle biopsy: a pilot study.
- Author
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Dos Santos JA, Capella DL, Rozza RE, Ferreira SJ, Berti-Couto Sde A, Sant'ana-Filho M, de Lima AA, Westphalen FH, and Couto-Souza PH
- Abstract
Objectives: The aim of this pilot study was to evaluate the effectiveness of cutting needle biopsy in the diagnosis of solid oral lesions., Material and Methods: The biopsies were carried out on seven patients who presented with solid oral lesions with sizes ranging from 2 to 6 cm. Specimens were obtained from each lesion before conventional biopsies using a cutting needle with 18-gauge x 9 cm (MD TECH, Gainesville, FL, USA). A total of 64 specimens processed by hematoxylin-eosin staining method, were obtained. Afterwards, the analysis was performed by an oral pathologist, in two different stages, with and without the clinical history of each lesion. Then, these answers were compared with the final histological diagnosis., Results: Results presented by the descriptive analysis showed that the correct diagnosis using cutting needle biopsy without the clinical history of lesions was registered in 37.5% of cases, while with the clinical history in 76.6%., Conclusions: Despite the promising results as a potential technique for biopsies and histological diagnosis of oral lesions, the cutting needle biopsy should be analyzed carefully in those cases.
- Published
- 2011
- Full Text
- View/download PDF
24. Spontaneous eruption of a canine after marsupialization of an infected dentigerous cyst.
- Author
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Berti Sde A, Pompermayer AB, Couto Souza PH, Tanaka OM, Westphalen VP, and Westphalen FH
- Subjects
- Bicuspid physiology, Child, Cyst Fluid, Follow-Up Studies, Humans, Male, Molar surgery, Tooth Extraction, Tooth, Deciduous surgery, Tooth, Unerupted physiopathology, Cuspid physiology, Dentigerous Cyst surgery, Mandibular Diseases surgery, Tooth Eruption physiology
- Abstract
A dentigerous cyst is the most common developmental odontogenic cyst. It is a benign and asymptomatic intraosseous lesion that affects the bones of the maxillofacial complex, interfering with tooth eruption. This article reports the spontaneous eruption of a canine after marsupialization of an infected dentigerous cyst and extraction of the deciduous teeth. A radiograph showed a large cyst with a radiolucent area involving the mandibular left deciduous canine and first molar, and the permanent canine and first premolar. Although enucleation is the treatment of choice, marsupialization is the best option for large cysts involving an unerupted permanent tooth, as in this case. The patient was followed for 1 year, and eruption of the permanent canine and first premolar and gradual reduction of the radiolucent area were observed., (Copyright (c) 2010 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
25. Spontaneous resolution of a central giant-cell granuloma after incisional biopsy: a case report.
- Author
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Berti SA, Couto Souza PH, Jacobs R, Lambrichts I, Corpas LS, Arruda EP, Martins WD, Westphalen FH, and Tolazzi AL
- Subjects
- Female, Granuloma, Giant Cell pathology, Granuloma, Giant Cell surgery, Humans, Mandibular Diseases pathology, Mandibular Diseases surgery, Middle Aged, Remission, Spontaneous, Granuloma, Giant Cell physiopathology, Mandibular Diseases physiopathology
- Published
- 2009
- Full Text
- View/download PDF
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