1. Non-cytotoxic Gamma-delta Peripheral T-cell Lymphoma Affecting the Mandibular and Parotidal Lymph Nodes and the Skin.
- Author
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Lima, Margarida, Canelhas, Aurea, Santos, Carlos, Dos Anjos Teixeira, Maria, Coutinio, Jorge, Alves, Rosário, Queirós, Maria Luís, Fonesca, Sónia, Santos, Anna Helena, Concalves, Vicente, Massa, Antonio, and Justiça, Benvindo
- Subjects
T cells ,LYMPH nodes ,LYMPHOMA treatment ,DRUG therapy ,TUMORS - Abstract
In contrast to the majority of αβ peripheral T cell lymphomas (PTCL), which usually originate in lymph nodes and do not express NK-associated molecules, most γδ PTCL express a cytotoxic phenotype and originate at extranodal sites. We report a case of a patient with a gamma-delta PTCL who presented with large mandibular and parotidal lymphadenopathy and skin lesions. CD3(+)/TCR-Vδ1(+) lymphoma cells did not express the cell surface (CD11b, CD11c, CD16, CD56 and CD57) and cytoplasmic granule molecules (Perforin and Granzyme B) that usually characterize the cytotoxic T-cells, a phenotype that fulfils the criteria for diagnosis of a rare non-cytotoxic variant of a γδ T-cell lymphoma. "In situ" hybridization for Epstein-Barr virus-encoded RNA and latent membrane protein-1 gave negative results. The disease had an aggressive course and was resistant to chemotherapy and the patient died 4 months after diagnosis. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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