193 results on '"Cousido-Siah, Alexandra"'
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2. Evidence for direct interaction between the oncogenic proteins E6 and E7 of high-risk Human Papillomavirus (HPV)
3. Author Correction: Quantitative fragmentomics allow affinity mapping of interactomes
4. Quantitative fragmentomics allow affinity mapping of interactomes
5. PDZome-wide and structural characterization of the PDZ-binding motif of VANGL2
6. Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase
7. Lipid exchange in crystal‐confined fatty acid binding proteins: X‐ray evidence and molecular dynamics explanation
8. Lipid exchange in crystal-confined Fatty Acid Binding Proteins: X-ray evidence and Molecular Dynamics explanation
9. The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase
10. X-rays-Induced Cooperative Atomic Movement in a Protein Crystal
11. Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53
12. Frataxin from Psychromonas ingrahamii as a model to study stability modulation within the CyaY protein family
13. Structural characterization of metal binding to a cold-adapted frataxin
14. High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression
15. A scalable strategy to solve structures of PDZ domains and their complexes
16. Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants
17. Quantum Model of Catalysis Based on a Mobile Proton Revealed by Subatomic X-Ray and Neutron Diffraction Studies of h-Aldose Reductase
18. Quantitative fragmentomics allow affinity mapping of interactomes
19. X-rays-Induced Cooperative Atomic Movement in a Protein Crystal
20. Conformational editing of intrinsically disordered protein by α-methylation
21. Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex Formation
22. Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10
23. Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study
24. A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth
25. Enhancing Binding Affinity of an Intrinsically Disordered Protein by α-Methylation of Key Amino Acid Residues
26. Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II
27. Structural Basis of Outstanding Multivalent Effects in Jack Bean α‐Mannosidase Inhibition
28. Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma
29. Probing The Roles Of Two Tryptophans Surrounding The Unique Zinc Coordination Site In Lipase Family I.5
30. Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008
31. Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma
32. Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II
33. Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction
34. 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors
35. An ab initio fully deuterated tiny crystal (1x0.25x0.20mm) allows neutron data collection at room temperature up to 1.90Å
36. High resolution neutron and X-ray diffraction RT studies of an H-FABP – Oleic acid complex: study of the internal water cluster and the ligand binding by a transferred multipolar electron density distribution
37. IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors
38. X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain
39. Iminosugar-Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels
40. Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5
41. Crystal packing modifies ligand binding affinity: The case of aldose reductase
42. Cover Picture: Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10 (ChemMedChem 12/2015)
43. Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10
44. Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase
45. New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM
46. Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10
47. The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition
48. Structural and mechanistic studies of human chitinase
49. X-ray structures of Aldose Reductase and AKR1B10 with the lead inhibitor JF0064
50. UHR PX and NPC studies of H-FABP water network with tiny perdeuterated crystals
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