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2. The First Modified Delphi Consensus-Building Exercise on Surgical Ward Rounds in the United Kingdom National Health Service

Author

Amr, Bassem, Omar, Islam, Abdelrahman, Mohamed, Abdalkoddus, Muhammad, Abou El Ella, Yasmin, Abouelazayem, Mohamed, Abubakr, Mohammed O. A., Andrews, Sian, Awad, Sherif, Bunting, David, Callejas-Diaz, Lindes, Cambridge, William A., Carr, William, Chesworth, Angela, Courtney, Michael J., edge, Jemma, Froghi, Farid, Gilliam, Andrew, graham, Yitka, Harwood, Sarah, Hollyman, Marianne, Kimble, Adam, kotb, Ahmed, Majithia, Ridhi, Mallinson, Sue, Metcalfe, Nicky, O’Kane, Mary, Parmar, Chetan, Saiyed, Saniya, Shaban, Mohamed, Singhal, Rishi, Trewin, Lisa, Wadhawan, Himanshu, and Mahawar, Kamal

Published
2023
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12. Preoperative risk factors for conversion from laparoscopic to open cholecystectomy: a validated risk score derived from a prospective U.K. database of 8820 patients

Author

Fenwick, Stephen, Elmasry, Mohamed, Nunes, Quentin, Kennedy, David, Khan, Raja B., Khan, Muhammad A.S., Magee, Conor J., Jones, Steven M., Mason, Denise, Parappally, Ciny P., Mathur, Pawan, Saunders, Michael, Jamel, Sara, Haque, Samer U.l., Zafar, Sara, Shiwani, Muhammad H., Samuel, Nehemiah, Dar, Farooq, Jackson, Andrew, Lovett, Bryony, Dindyal, Shiva, Winter, Hannah, Rahman, Saquib, Wheatley, Kevin, Nieto, Tom, Ayaani, Soofiyah, Youssef, Haney, Nijjar, Rajwinder S., Watkin, Helen, Naumann, David, Emeshi, Sophie, Sarmah, Piyush B., Lee, Kathryn, Joji, Nikita, Heath, Jonathan, Teasdale, Rebecca L., Weerasinghe, Chamindri, Needham, Paul J., Welbourn, Hannah, Forster, Luke, Finch, David, Blazeby, Jane M., Robb, William, McNair, Angus G.K., Hrycaiczuk, Alex, Charalabopoulos, Alexandros, Kadirkamanathan, Sritharan, Tang, Cheuk-Bong, Jayanthi, Naga V.G., Noor, Nigel, Dobbins, Brian, Cockbain, Andrew J., Nilsen-Nunn, April, de Siqueira, Jonathan, Pellen, Mike, Cowley, Jonathan B., Ho, Wei-Min, Miu, Victor, White, Timothy J., Hodgkins, Kathryn A., Kinghorn, Alison, Tutton, Matthew G., Al-Abed, Yahya A., Menzies, Donald, Ahmad, Anwar, Reed, Joanna, Khan, Shabuddin, Monk, David, Vitone, Louis J., Murtaza, Ghulam, Joel, Abraham, Brennan, Stephen, Shier, David, Zhang, Catherine, Yoganathan, Thusidaran, Robinson, Steven J., McCallum, Iain J.D., Jones, Michael J., Elsayed, Mohammed, Tuck, Liz, Wayman, John, Carney, Kate, Aroori, Somaiah, Hosie, Kenneth B., Kimble, Adam, Bunting, David M., Fawole, Adeshina S., Basheer, Mohammed, Dave, Rajiv V., Sarveswaran, Janahan, Jones, Elinor, Kendal, Chris, Tilston, Michael P., Gough, Martin, Wallace, Tom, Singh, Shailendra, Downing, Justine, Mockford, Katherine A., Issa, Eyad, Shah, Nayab, Chauhan, Neal, Wilson, Timothy R., Forouzanfar, Amir, Wild, Jonathan R.L., Nofal, Emma, Bunnell, Catherine, Madbak, Khaliel, Rao, Sudhindra T.V., Devoto, Laurence, Siddiqi, Najaf, Khawaja, Zechan, Hewes, James C., Gould, Laura, Chambers, Alice, Rodriguez, Daniel U., Sen, Gourab, Robinson, Stuart, Bartlett, Francis, Rae, David M., Stevenson, Thomas E.J., Sarvananthan, Kas, Dwerryhouse, Simon J., Higgs, Simon M., Old, Oliver J., Hardy, Thomas J., Shah, Reena, Hornby, Steve T., Keogh, Ken, Frank, Lucinda, Al-Akash, Musallam, Upchurch, Emma A., Frame, Richard J., Hughes, Michael, Jelley, Clare, Weaver, Simon, Roy, Sudipta, Sillo, Toritseju O., Galanopoulos, Giorgios, Cuming, Tamzin, Cunha, Pedro, Tayeh, Salim, Kaptanis, Sarantos, Heshaishi, Mohamed, Eisawi, Abdalla, Abayomi, Michael, Ngu, Wee S., Fleming, Katie, Bajwa, Dalvir S., Chitre, Vivek, Aryal, Kamal, Ferris, Paul, Silva, Michael, Lammy, Simon, Mohamed, Sarah, Khawaja, Amir, Hussain, Adnan, Ghazanfar, Mudassar A., Bellini, Maria I., Ebdewi, Hamdi, Elshaer, Mohamed, Gravante, Gianpiero, Drake, Benjamin, Ogedegbe, Arikoge, Mukherjee, Dipankar, Arhi, Chanpreet, Giwa, Lola, Iqbal, Nusrat, Watson, Nicholas F., Aggarwal, Smeer K., Orchard, Philippa, Villatoro, Eduardo, Willson, Peter D., Mok, Kam W.J., Woodman, Thomas, Deguara, Jean, Garcea, Giuseppe, Babu, Benoy I., Dennison, Alistair R., Malde, Deep, Lloyd, David, Slavin, John P., Jones, Robert P., Ballance, Laura, Gerakopoulos, Stratos, Jambulingam, Periyathambi, Mansour, Sami, Sakai, Naomi, Acharya, Vikas, Sadat, Mohammed M., Karim, Lawen, Larkin, David, Amin, Khalid, Khan, Amarah, Law, Jennifer, Jamdar, Saurabh, Smith, Stella R., Sampat, Keerthika, O'shea, Kathryn M., Manu, Mangta, Asprou, Fotini M., Malik, Nabeela S., Chang, Jessica, Johnstone, Marianne, Lewis, Michael, Roberts, Geoffrey P., Karavadra, Babu, Photi, Evangelos, Hewes, James, Rodriguez, Dan, O'Reilly, Derek A., Rate, Anthony J., Sekhar, Hema, Henderson, Lucy T., Starmer, Benjamin Z., Coe, Peter O., Tolofari, Sotonye, Barrie, Jenifer, Bashir, Gareth, Sloane, Jake, Madanipour, Suroosh, Halkias, Constantine, Trevatt, Alexander E.J., Borowski, David W., Hornsby, Jane, Courtney, Michael J., Virupaksha, Suvi, Seymour, Keith, Robinson, Sarah, Hawkins, Helen, Bawa, Sadiq, Gallagher, Paul V., Reid, Alistair, Wood, Peter, Finch, Jonathan G., Finch, J.Guy, Parmar, Jitesh, Stirland, Euan, Gardner-Thorpe, James, Al-Muhktar, Ahmed, Peterson, Mark, Majeed, Ali, Bajwa, Farrukh M., Martin, Jack, Choy, Alfred, Tsang, Andrew, Pore, Naresh, Andrew, David R., Al-Khyatt, Waleed, Santosh Bhandari, Christopher Taylor, Chambers, Adam, Subramanium, Dhivya, Toh, Simon K.C., Carter, Nicholas C., Mercer, Stuart J., Knight, Benjamin, Vijay, Vardhini, Alagaratnam, Swethan, Sinha, Sidhartha, Khan, Shahab, El-Hasani, Shamsi S., Hussain, Abdulzahra A., Bhattacharya, Vish, Kansal, Nisheeth, Fasih, Tani, Jackson, Claire, Siddiqui, Midhat N., Chishti, Imran A., Fordham, Imogen J., Siddiqui, Zohaib, Bausbacher, Harald, Geogloma, Ileana, Gurung, Kabita, Tsavellas, George, Basynat, Pradeep, Shrestha, Ashish K., Basu, Sanjoy, Chhabra, Alok, Harilingam, Mohan, Rabie, Mohamed, Akhtar, Mansoor, Kumar, Pradeep, Jafferbhoy, Sadaf F., Hussain, Najam, Raza, Soulat, Haque, Manzarul, Alam, Imran, Aseem, Rabiya, Patel, Shakira, Asad, Mehek, Booth, Michael I., Ball, William R., Wood, Christopher P.J., Pinho-Gomes, Ana C., Kausar, Ambareen, Obeidallah, Mohammed, Varghase, Joseph, Lodhia, Joshil, Bradley, Donal, Rengifo, Carla, Lindsay, David, Gopalswamy, Sivakumar, Finlay, Ian, Wardle, Stacy, Bullen, Naomi, Iftikhar, Syed Y., Awan, Altaf, Ahmed, Javed, Leeder, Paul, Fusai, Guiseppe, Bond-Smith, Giles, Psica, Alicja, Puri, Yogesh, Hou, David, Noble, Fergus, Szentpali, Karoly, Broadhurst, Jack, Date, Ravindra, Hossack, Martin R., Goh, Yan L., Turner, Paul, Shetty, Vinutha, Riera, Manel, Macano, Christina A.W., Sukha, Anisha, Preston, Shaun R., Hoban, Jennifer R., Puntis, Daniel J., Williams, Sophie V., Krysztopik, Richard, Kynaston, James, Batt, Jeremy, Doe, Matthew, Goscimski, Andrzej, Jones, Gareth H., Hall, Claire, Carty, Nick, Ahmed, Jamil, Panteleimonitis, Sofoklis, Gunasekera, Rohan T., Sheel, Andrea R.G., Lennon, Hannah, Hindley, Caroline, Reddy, Marcus, Kenny, Ross, Elkheir, Natalie, McGlone, Emma R., Rajaganeshan, Rajasundaram, Hancorn, Kate, Hargreaves, Anita, Prasad, Raj, Longbotham, David A., Vijayanand, Dhakshinamoorthy, Wijetunga, Imeshi, Ziprin, Paul, Nicolay, Christopher R., Yeldham, Geoffrey, Read, Edward, Gossage, James A., Rolph, Rachel C., Ebied, Husam, Phull, Manraj, Khan, Mohammad A., Popplewell, Matthew, Kyriakidis, Dimitrios, Hussain, Anwar, Henley, Natasha, Packer, Jessica R., Derbyshire, Laura, Porter, Jonathan, Appleton, Shaun, Farouk, Marwan, Basra, Melvinder, Jennings, Neil A., Ali, Shahda, Kanakala, Venkatesh, Ali, Haythem, Lane, Risha, Dickson-Lowe, Richard, Zarsadias, Prizzi, Mirza, Darius, Puig, Sonia, Al Amari, Khalid, Vijayan, Deepak, Sutcliffe, Robert, Marudanayagam, Ravi, Hamady, Zayed, Prasad, Abheesh R., Patel, Abhilasha, Durkin, Damien, Kaur, Parminder, Bowen, Laura, Byrne, James P., Pearson, Katherine L., Delisle, Theo G., Davies, James, Tomlinson, Mark A., Johnpulle, Michelle A., Slawinski, Corinna, Macdonald, Andrew, Nicholson, James, Newton, Katy, Mbuvi, James, Farooq, Ansar, Mothe, Bhavani S., Zafrani, Zakhi, Brett, Daniel, Francombe, James, Spreadborough, Philip, Barnes, James, Cheung, Melanie, Al-Bahrani, Ahmed Z., Preziosi, Giuseppe, Urbonas, Tomas, Alberts, Justin, Mallik, Mekhlola, Patel, Krashna, Segaran, Ashvina, Doulias, Triantafyllos, Sufi, Pratik A., Yao, Caroline, Pollock, Sarah, Manzelli, Antonio, Wajed, Saj, Kourkulos, Michail, Pezzuto, Roberto, Wadley, Martin, Hamilton, Emma, Jaunoo, Shameen, Padwick, Robert, Sayegh, Mazin, Newton, Richard C., Hebbar, Madhusoodhana, Farag, Sameh F., Hebbar, Madhu, Spearman, John, Hamdan, Mohammed F., D'Costa, Conrad, Blane, Christine, Giles, Mathew, Peter, Mark B., Hirst, Natalie A., Hossain, Tanvir, Pannu, Arslan, El-Dhuwaib, Yesar, Morrison, Tamsin E.M., Taylor, Greg W., Thompson, Ronald L.E., McCune, Ken, Loughlin, Paula, Lawther, Roger, Byrnes, Colman K., Simpson, Duncan J., Mawhinney, Abi, Warren, Conor, McKay, Damian, McIlmunn, Colin, Martin, Serena, MacArtney, Matthew, Diamond, Tom, Davey, Phil, Jones, Claire, Clements, Joshua M., Digney, Ruairi, Chan, Wei M., McCain, Stephen, Gull, Sadaf, Janeczko, Adam, Dorrian, Emmet, Harris, Andrew, Dawson, Suzanne, Johnston, Dorothy, McAree, Barry, Ghareeb, Essam, Thomas, George, Connelly, Martin, McKenzie, Stephen, Cieplucha, Krzysztos, Spence, Gary, Campbell, William, Hooks, Gareth, Bradley, Neil, Hill, Arnold D.K., Cassidy, John T., Boland, Michael, Burke, Paul, Nally, Deirdre M., Khogali, Elmoataz, Shabo, Wael, Iskandar, Edrin, McEntee, Gerry P., O'Neill, Maeve A., Peirce, Colin, Lyons, Emma M., O'Sullivan, Adrian W., Thakkar, Rohan, Carroll, Paul, Ivanovski, Ivan, Balfe, Paul, Lee, Matthew, Winter, Des C., Kelly, Michael E., Hoti, Emir, Maguire, Donal, Karunakaran, Priyadarssini, Geoghegan, Justin G., Martin, Sean T., Cross, Keith S., Cooke, Fiachra, Zeeshan, Saquib, Murphy, James O., Mealy, Ken, Mohan, Helen M., Nedujchelyn, Yuwaraja, Ullah, Muhammad F., Ahmed, Irfan, Giovinazzo, Francesco, Milburn, James, Prince, Sarah, Brooke, Eleanor, Buchan, Joanna, Khalil, Ahmed M., Vaughan, Elizabeth M., Ramage, Michael I., Aldridge, Roland C., Gibson, Simon, Nicholson, Gary A., Vass, David G., Grant, Alan J., Holroyd, David J., Jones, Angharad, Sutton, Cherith M.L.R., O'Dwyer, Patrick, Nilsson, Frida, Weber, Beatrix, Williamson, Tracey K., Lalla, Kushik, Bryant, Alice, Carter, Ross, Forrest, Craig R., Hunter, David I., Nassar, Ahmad H., Orizu, Mavis N., Knight, Katrina, Qandeel, Haitham, Suttie, Stuart, Belding, Rowena, McClarey, Andrew, Boyd, Alan T., Guthrie, Graeme J.K., Lim, Pei J., Luhmann, Andreas, Watson, Angus J.M., Richards, Colin H., Nicol, Laura, Madurska, Marta, Harrison, Ewen, Boyce, Kathryn M., Roebuck, Amanda, Ferguson, Graeme, Pati, Pradeep, Wilson, Michael S.J., Dalgaty, Faith, Fothergill, Laura, Driscoll, Peter J., Mozolowski, Kirsty L., Banwell, Victoria, Bennett, Stephen P., Rogers, Paul N., Skelly, Brendan L., Rutherford, Claire L., Mirza, Ahmed K., Lazim, Taha, Lim, Henry C.C., Duke, Diana, Ahmed, Talat, Beasley, William D., Wilkinson, Marc D., Maharaj, Geta, Malcolm, Cathy, Brown, Timothy H., Shingler, Guy M., Mowbray, Nicholas, Radwan, Rami, Morcous, Paul, Wood, Simon, Kadhim, Abbas, Stewart, Duncan J., Baker, Andrew L., Tanner, Nicola, Shenoy, Hrishikesh, Sutcliffe, Robert P., Hollyman, Marianne, Hodson, James, Bonney, Glenn, Vohra, Ravi S., and Griffiths, Ewen A.

Published
2016
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15. Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders

Author

Freudenberg, Florian, primary, Candemir, Esin, additional, Chen, Xufeng, additional, Li, Li-Li, additional, Esen-Sehir, Dilhan, additional, Schenk, Nicole, additional, Kinoshita, Makoto, additional, Grünewald, Lena, additional, Frerichs, Veronika, additional, Fattakhov, Nikolai, additional, Manchen, Jessica, additional, Bikas, Solmaz, additional, Kumar, Anita, additional, OLeary, Aet, additional, Slattery, David A., additional, von Engelhardt, Jakob, additional, Courtney, Michael J., additional, and Reif, Andreas, additional

Published
2021
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16. Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders

Author

Freudenberg, Florian, Candemir, Esin, Chen, Xufeng, Li, Li-Li, Esen-Sehir, Dilhan, Schenk, Nicole, Kinoshita, Makoto, Grünewald, Lena, Frerichs, Veronika, Fattakhov, Nikolai, Manchen, Jessica, Bikas, Solmaz, Kumar, Anita, OLeary, Aet, Slattery, David A., von Engelhardt, Jakob, Courtney, Michael J., Reif, Andreas, Freudenberg, Florian, Candemir, Esin, Chen, Xufeng, Li, Li-Li, Esen-Sehir, Dilhan, Schenk, Nicole, Kinoshita, Makoto, Grünewald, Lena, Frerichs, Veronika, Fattakhov, Nikolai, Manchen, Jessica, Bikas, Solmaz, Kumar, Anita, OLeary, Aet, Slattery, David A., von Engelhardt, Jakob, Courtney, Michael J., and Reif, Andreas

Abstract

Background: Nitric oxide synthase 1 adaptor protein (NOS1AP; previously named CAPON) is linked to the glutamatergic postsynaptic density through interaction with neuronal nitric oxide synthase (nNOS). NOS1AP and its interaction with nNOS have been associated with several mental disorders. Despite the high levels of NOS1AP expression in the hippocampus and the relevance of this brain region in glutamatergic signalling as well as mental disorders, a potential role of hippocampal NOS1AP in the pathophysiology of these disorders has not been investigated yet. Methods: To uncover the function of NOS1AP in hippocampus, we made use of recombinant adeno-associated viruses to overexpress murine full-length NOS1AP or the NOS1AP carboxyterminus in the hippocampus of mice. We investigated these mice for changes in gene expression, neuronal morphology, and relevant behavioural phenotypes. Findings: We found that hippocampal overexpression of NOS1AP markedly increased the interaction of nNOS with PSD-95, reduced dendritic spine density, and changed dendritic spine morphology at CA1 synapses. At the behavioural level, we observed an impairment in social memory and decreased spatial working memory capacity. Interpretation: Our data provide a mechanistic explanation for a highly selective and specific contribution of hippocampal NOS1AP and its interaction with the glutamatergic postsynaptic density to cross-disorder pathophysiology. Our findings allude to therapeutic relevance due to the druggability of this molecule. Funding: This study was funded in part by the DFG, the BMBF, the Academy of Finland, the NIH, the Japanese Society of Clinical Neuropsychopharmacology, the Ministry of Education of the Russian Federation, and the European Community.

Published
2021

17. Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy

Author

Griffiths, Ewen A, Hodson, James, Vohra, Ravi S, Marriott, Paul, Katbeh, Tarek, Zino, Samer, Nassar, Ahmad HM, Vohra, Ravinder S, Kirkham, Amanda J, Pasquali, Sandro, Johnstone, Marianne, Spreadborough, Philip, Alderson, Derek, Fenwick, Stephen, Elmasry, Mohamed, Nunes, Quentin M, Kennedy, David, Khan, Raja Basit, Khan, Muhammad AS, Magee, Conor J, Jones, Steven M, Mason, Denise, Parappally, Ciny P, Mathur, Pawan, Saunders, Michael, Jamel, Sara, Haque, Samer Ul, Zafar, Sara, Shiwani, Muhammad Hanif, Samuel, Nehemiah, Dar, Farooq, Jackson, Andrew, Lovett, Bryony, Dindyal, Shiva, Winter, Hannah, Fletcher, Ted, Rahman, Saquib, Wheatley, Kevin, Nieto, Tom, Ayaani, Soofiyah, Youssef, Haney, Nijjar, Rajwinder S, Watkin, Helen, Naumann, David, Emesih, Sophie, Sarmah, Piyush B, Lee, Kathryn, Joji, Nikita, Lambert, Joel, Heath, Jonathan, Teasdale, Rebecca L, Weerasinghe, Chamindri, Needham, Paul J, Welbourn, Hannah, Forster, Luke, Finch, David, Blazeby, Jane M, Robb, William, McNair, Angus GK, Hrycaiczuk, Alex, Charalabopoulos, Alexandros, Kadirkamanathan, Sritharan, Tang, Cheuk-Bong, Jayanthi, Naga VG, Noor, Nigel, Dobbins, Brian, Cockbain, Andrew J, Nilsen-Nunn, April, de Siqueira, Jonathan, Pellen, Mike, Cowley, Jonathan B, Ho, Wei-Min, Miu, Victor, White, Timothy J, Hodgkins, Kathryn A, Kinghorn, Alison, Tutton, Matthew G, Al-Abed, Yahya A, Menzies, Donald, Ahmad, Anwar, Reed, Joanna, Khan, Shabuddin, Monk, David, Vitone, Louis J, Murtaza, Ghulam, Joel, Abraham, Brennan, Stephen, Shier, David, Zhang, Catherine, Yoganathan, Thusidaran, Robinson, Steven J, McCallum, Iain JD, Jones, Michael J, Elsayed, Mohammed, Tuck, Liz, Wayman, John, Carney, Kate, Aroori, Somaiah, Hosie, Kenneth B, Kimble, Adam, Bunting, David M, Fawole, Adeshina S, Basheer, Mohammed, Dave, Rajiv V, Sarveswaran, Janahan, Jones, Elinor, Kendal, Chris, Tilston, Michael P, Gough, Martin, Wallace, Tom, Singh, Shailendra, Downing, Justine, Mockford, Katherine A, Issa, Eyad, Shah, Nayab, Chauhan, Neal, Wilson, Timothy R, Forouzanfar, Amir, Wild, Jonathan RL, Nofal, Emma, Bunnell, Catherine, Madbak, Khaliel, Rao, Sudhindra TV, Devoto, Laurence, Siddiqi, Najaf, Khawaja, Zechan, Hewes, James C, Gould, Laura, Chambers, Alice, Rodriguez, Daniel Urriza, Sen, Gourab, Robinson, Stuart, Bartlett, Francis, Rae, David M, Stevenson, Thomas EJ, Sarvananthan, Kas, Dwerryhouse, Simon J, Higgs, Simon M, Old, Oliver J, Hardy, Thomas J, Shah, Reena, Hornby, Steve T, Keogh, Ken, Frank, Lucinda, Al-Akash, Musallam, Upchurch, Emma A, Frame, Richard J, Hughes, Michael, Jelley, Clare, Weaver, Simon, Roy, Sudipta, Sillo, Toritseju O, Galanopoulos, Giorgios, Cuming, Tamzin, Cunha, Pedro, Tayeh, Salim, Kaptanis, Sarantos, Heshaishi, Mohamed, Eisawi, Abdalla, Abayomi, Michael, Ngu, Wee Sing, Fleming, Katie, Bajwa, Dalvi S, Chitre, Vivek, Aryal, Kamal, Ferris, Paul, Silva, Michael, Lammy, Simon, Mohamed, Sarah, Khawaja, Amir, Hussain, Adnan, Ghazanfar, Mudassar A, Bellini, Maria Irene, Ebdewi, Hamdi, Elshaer, Mohamed, Gravante, Gianpiero, Drake, Benjamin, Ogedegbe, Arikoge, Mukherjee, Dipankar, Arhi, Chanpreet, Giwa, Lola, Iqbal, Nusrat, Watson, Nicholas F, Aggarwal, Smeer Kumar, Orchard, Philippa, Villatoro, Eduardo, Willson, Peter D, Mok, Kam Wa Jessica, Woodman, Thomas, Deguara, Jean, Garcea, Giuseppe, Babu, Benoy I, Dennison, AR, Malde, Deep, Lloyd, David, Satheesan, Steve, Al-Taan, Omer, Boddy, Alexander, Slavin, John P, Jones, Robert P, Ballance, Laura, Gerakopoulos, Stratos, Jambulingam, Periyathambi, Mansour, Sami, Sakai, Naomi, Acharya, Vikas, Sadat, Mohammed M, Karim, Lawen, Larkin, David, Amin, Khalid, Khan, Amarah, Law, Jennifer, Jamdar, Saurabh, Smith, Stella R, Sampat, Keerthika, O'shea, Kathryn M, Manu, Mangta, Asprou, Fotini M, Malik, Nabeela S, Chang, Jessica, Lewis, Michael, Roberts, Geoffrey P, Karavadra, Babu, Photi, Evangelos, Hewes, James, Rodriguez, Dan, O'Reilly, Derek A, Rate, Anthony J, Sekhar, Hema, Henderson, Lucy T, Starmer, Benjamin Z, Coe, Peter O, Tolofari, Sotonye, Barrie, Jenifer, Bashir, Gareth, Sloane, Jake, Madanipour, Suroosh, Halkias, Constantine, Trevatt, Alexander EJ, Borowski, David W, Hornsby, Jane, Courtney, Michael J, Virupaksha, Suvi, Seymour, Keith, Robinson, Sarah, Hawkins, Helen, Bawa, Sadiq, Gallagher, Paul V, Reid, Alistair, Wood, Peter, Finch, JG, Finch, J Guy, Parmar, J, Stirland, E, Gardner-Thorpe, James, Al-Muhktar, Ahmed, Peterson, Mark, Majeed, Ali, Bajwa, Farrukh M, Martin, Jack, Choy, Alfred, Tsang, Andrew, Pore, Naresh, Andrew, David R, Al-Khyatt, Waleed, Bhandari, Christopher Taylor Santosh, Chambers, Adam, Subramanium, Dhivya, Toh, Simon KC, Carter, Nicholas C, Tate, Sophie, Pearce, Belinda, Wainwright, Denise, Mercer, Stuart J, Knight, Benjamin, Vijay, Vardhini, Alagaratnam, Swethan, Sinha, Sidhartha, Khan, Shahab, El-Hasani, Shamsi S, Hussain, Abdulzahra A, Bhattacharya, Vish, Kansal, Nisheeth, Fasih, Tani, Jackson, Claire, Siddiqui, Midhat N, Chishti, Imran A, Fordham, Imogen J, Siddiqui, Zohaib, Bausbacher, Harald, Geogloma, Ileana, Gurung, Kabita, Tsavellas, George, Basynat, Pradeep, Shrestha, Ashish Kiran, Basu, Sanjoy, Harilingam, Alok Chhabra Mohan, Rabie, Mohamed, Akhtar, Mansoor, Kumar, Pradeep, Jafferbhoy, Sadaf F, Hussain, Najam, Raza, Soulat, Haque, Manzarul, Alam, Imran, Aseem, Rabiya, Patel, Shakira, Asad, Mehek, Booth, Michael I, Ball, William R, Wood, Christopher PJ, Pinho-Gomes, Ana C, Kausar, Ambareen, Obeidallah, Moh'd Rami, Varghase, Joseph, Lodhia, Joshil, Bradley, Donal, Rengifo, Carla, Lindsay, David, Gopalswamy, Sivakumar, Finlay, Ian, Wardle, Stacy, Bullen, Naomi, Iftikhar, Syed Yusuf, Awan, Altaf, Ahmed, Javed, Leeder, Paul, Fusai, Guiseppe, Bond-Smith, Giles, Psica, Alicja, Puri, Yogesh, Hou, David, Noble, Fergus, Szentpali, Karoly, Broadhurst, Jack, Date, Ravindra, Hossack, Martin R, Goh, Yan Li, Turner, Paul, Shetty, Vinutha, Riera, Manel, Macano, Christina AW, Sukha, Anisha, Preston, Shaun R, Hoban, Jennifer R, Puntis, Daniel J, Williams, Sophie V, Krysztopik, Richard, Kynaston, James, Batt, Jeremy, Doe, Matthew, Goscimski, Andrzej, Jones, Gareth H, Hall, Claire, Carty, Nick, Ahmed, Jamil, Panteleimonitis, Sofoklis, Gunasekera, Rohan T, Sheel, Andrea RG, Lennon, Hannah, Hindley, Caroline, Reddy, Marcus, Kenny, Ross, Elkheir, Natalie, McGlone, Emma R, Rajaganeshan, Rajasundaram, Hancorn, Kate, Hargreaves, Anita, Prasad, Raj, Longbotham, David A, Vijayanand, Dhakshinamoorthy, Wijetunga, Imeshi, Ziprin, Paul, Nicolay, Christopher R, Yeldham, Geoffrey, Read, Edward, Gossage, James A, Rolph, Rachel C, Ebied, Husam, Phull, Manraj, Khan, Mohammad A, Popplewell, Matthew, Kyriakidis, Dimitrios, Hussain, Anwar, Henley, Natasha, Packer, Jessica R, Derbyshire, Laura, Porter, Jonathan, Appleton, Shaun, Farouk, Marwan, Basra, Melvinder, Jennings, Neil A, Ali, Shahda, Kanakala, Venkatesh, Ali, Haythem, Lane, Risha, Dickson-Lowe, Richard, Zarsadias, Prizzi, Mirza, Darius, Puig, Sonia, Al Amari, Khalid, Vijayan, Deepak, Sutcliffe, Robert, Marudanayagam, Ravi, Hamady, Zayed, Prasad, Abheesh R, Patel, Abhilasha, Durkin, Damien, Kaur, Parminder, Bowen, Laura, Byrne, James P, Pearson, Katherine L, Delisle, Theo G, Davies, James, Tomlinson, Mark A, Johnpulle, Michelle A, Slawinski, Corinna, Macdonald, Andrew, Nicholson, James, Newton, Katy, Mbuvi, James, Farooq, Ansar, Mothe, Bhavani Sidhartha, Zafrani, Zakhi, Brett, Daniel, Francombe, James, Barnes, James, Cheung, Melanie, Al-Bahrani, Ahmed Z, Preziosi, Giuseppe, Urbonas, Tomas, Alberts, Justin, Mallik, Mekhlola, Patel, Krashna, Segaran, Ashvina, Doulias, Triantafyllos, Sufi, Pratik A, Yao, Caroline, Pollock, Sarah, Manzelli, Antonio, Wajed, Saj, Kourkulos, Michail, Pezzuto, Roberto, Wadley, Martin, Hamilton, Emma, Jaunoo, Shameen, Padwick, Robert, Sayegh, Mazin, Newton, Richard C, Hebbar, Madhusoodhana, Farag, Sameh F, Spearman, John, Hamdan, Mohammed F, D'Costa, Conrad, Blane, Christine, Giles, Mathew, Peter, Mark B, Hirst, Natalie A, Hossain, Tanvir, El-Dhuwaib, Arslan Pannu Yesar, Morrison, Tamsin EM, Taylor, Greg W, Thompson, Ronald LE, McCune, Ken, Loughlin, Paula, Lawther, Roger, Byrnes, Colman K, Simpson, Duncan J, Mawhinney, Abi, Warren, Conor, McKay, Damian, McIlmunn, Colin, Martin, Serena, MacArtney, Matthew, Diamond, Tom, Davey, Phil, Jones, Claire, Clements, Joshua M, Digney, Ruairi, Chan, Wei Ming, McCain, Stephen, Gull, Sadaf, Janeczko, Adam, Dorrian, Emmet, Harris, Andrew, Dawson, Suzanne, Johnston, Dorothy, McAree, Barry, Ghareeb, Essam, Thomas, George, Connelly, Martin, McKenzie, Stephen, Cieplucha, Krzysztos, Spence, Gary, Campbell, William, Hooks, Gareth, Bradley, Neil, Hill, Arnold DK, Cassidy, John T, Boland, Michael, Burke, Paul, Nally, Deirdre M, Khogali, Elmoataz, Shabo, Wael, Iskandar, Edrin, McEntee, Gerry P, O'Neill, Maeve A, Peirce, Colin, Lyons, Emma M, O'Sullivan, Adrian W, Thakkar, Rohan, Carroll, Paul, Ivanovski, Ivan, Balfe, Paul, Lee, Matthew, Winter, Des C, Kelly, Michael E, Hoti, Emir, Maguire, Donal, Karunakaran, Priyadarssini, Geoghegan, Justin G, McDermott, Frank, Martin, Sean T, Cross, Keith S, Cooke, Fiachra, Zeeshan, Saquib, Murphy, James O, Mealy, Ken, Mohan, Helen M, Nedujchelyn, Yuwaraja, Ullah, Muhammad Fahad, Ahmed, Irfan, Giovinazzo, Francesco, Milburn, James, Prince, Sarah, Brooke, Eleanor, Buchan, Joanna, Khalil, Ahmed M, Vaughan, Elizabeth M, Ramage, Michael I, Aldridge, Roland C, Gibson, Simon, Nicholson, Gary A, Vass, David G, Grant, Alan J, Holroyd, David J, Jones, M Angharad, Sutton, Cherith MLR, O'Dwyer, Patrick, Nilsson, Frida, Weber, Beatrix, Williamson, Tracey K, Lalla, Kushik, Bryant, Alice, Carter, C Ross, Forrest, Craig R, Hunter, David I, Nassar, Ahmad H, Orizu, Mavis N, Knight, Katrina, Qandeel, Haitham, Suttie, Stuart, Belding, Rowena, McClarey, Andrew, Boyd, Alan T, Guthrie, Graeme JK, Lim, Pei J, Luhmann, Andreas, Watson, Angus JM, Richards, Colin H, Nicol, Laura, Madurska, Marta, Harrison, Ewen, Boyce, Kathryn M, Roebuck, Amanda, Ferguson, Graeme, Pati, Pradeep, Wilson, Michael SJ, Dalgaty, Faith, Fothergill, Laura, Driscoll, Peter J, Mozolowski, Kirsty L, Banwell, Victoria, Bennett, Stephen P, Rogers, Paul N, Skelly, Brendan L, Rutherford, Claire L, Mirza, Ahmed K, Lazim, Taha, Lim, Henry CC, Duke, Diana, Ahmed, Talat, Beasley, William D, Wilkinson, Marc D, Maharaj, Geta, Malcolm, Cathy, Brown, Timothy H, Al-Sarireh, Bilal, Shingler, Guy M, Mowbray, Nicholas, Radwan, Rami, Morcous, Paul, Wood, Simon, Kadhim, Abbas, Stewart, Duncan J, Baker, Andrew L, Tanner, Nicola, Shenoy, Hrishikesh, Hafiz, Shazia, De Marchi, Joshua A, Singh-Ranger, Deepak, Hisham, Elzanati, Ainley, Paul, O'Neill, Stephen, Terrace, John, Napetti, Sara, Hopwood, Benjamin, Rhys, Thomas, Kanavati, Osama, Coats, Maria, Aleksandrov, Danail, Kallaway, Charlotte, Yahya, Salama, Templeton, Alexa, Trotter, Martin, Lo, Christina, Dhillon, Ajit, Heywood, Nick, Aawsaj, Yousif, Hamdan, Alhafidz, Reece-Bolton, Obuobi, McGuigan, Andrew, Shahin, Yousef, Aymon, Luther, Ali Alison, Nicholson, James A, Rajendran, Ilayaraja, Boal, Matthew, Ritchie, Judith, Grp, CholeS Study, Collaborative, West Midlands Res, Segaran, A, and Collaborative, West Midlands Research

Subjects
medicine.medical_specialty, medicine.medical_treatment, 030230 surgery, Article, 03 medical and health sciences, 0302 clinical medicine, Case mix index, Laparoscopic, length of stay, male, middle aged, postoperative complications, Medicine, Cholecystectomy, Prospective cohort study, Grading (education), humans, Laparoscopic cholecystectomy, business.industry, General surgery, adult, cholecystectomy, difficulty grading, laparoscopic, operative difficulty, surgery, aged, cholecystectomy, laparoscopic, conversion to open surgery, female, multivariate analysis, prospective studies, ROC curve, Difficulty grading, Cohort, 030211 gastroenterology & hepatology, Surgery, business, Operative difficulty, Grading scale, Abdominal surgery
Abstract

Background A reliable system for grading operative difficulty of laparoscopic cholecystectomy would standardise description of findings and reporting of outcomes. The aim of this study was to validate a difficulty grading system (Nassar scale), testing its applicability and consistency in two large prospective datasets. Methods Patient and disease-related variables and 30-day outcomes were identified in two prospective cholecystectomy databases: the multi-centre prospective cohort of 8820 patients from the recent CholeS Study and the single-surgeon series containing 4089 patients. Operative data and patient outcomes were correlated with Nassar operative difficultly scale, using Kendall’s tau for dichotomous variables, or Jonckheere–Terpstra tests for continuous variables. A ROC curve analysis was performed, to quantify the predictive accuracy of the scale for each outcome, with continuous outcomes dichotomised, prior to analysis. Results A higher operative difficulty grade was consistently associated with worse outcomes for the patients in both the reference and CholeS cohorts. The median length of stay increased from 0 to 4 days, and the 30-day complication rate from 7.6 to 24.4% as the difficulty grade increased from 1 to 4/5 (both p p Conclusion We have shown that an operative difficulty scale can standardise the description of operative findings by multiple grades of surgeons to facilitate audit, training assessment and research. It provides a tool for reporting operative findings, disease severity and technical difficulty and can be utilised in future research to reliably compare outcomes according to case mix and intra-operative difficulty.

Published
2018

18. JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length

Author

Tararuk, Tatsiana, Ostman, Nina, Li, Wenrui, Bjorkblom, Benny, Padzik, Artur, Zdrojewska, Justyna, Hongisto, Vesa, Herdegen, Thomas, Konopka, Witold, Courtney, Michael J., and Coffey, Eleanor T.

Subjects
Microtubules -- Research, Morphogenesis -- Research, Biological sciences
Abstract

C-Jun N[H.sub.2]-terminal kinases (JNKs) are essential during brain development, when they regulate morphogenic changes involving cell movement and migration. In the adult, JNK determines neuronal cyto-architecture. To help uncover the molecular effectors for JNKs in these events, we affinity purified JNK-interacting proteins from brain. This revealed that the stathmin family microtubule-destabilizing proteins SCG10, SCLIP, RB3, and RB3' interact tightly with JNK. Furthermore, SCG10 is also phosphorylated by JNK in vivo on sites that regulate its microtubule depolymerizing activity, serines 62 and 73. SCG10-S73 phosphorylation is significantly decreased in JNK1-/- cortex, indicating that JNK1 phosphorylates SCG10 in developing forebrain. JNK phosphorylation of SCG10 determines axodendritic length in cerebrocortical cultures, and JNK site-phosphorylated SCG10 colocalizes with active JNK in embryonic brain regions undergoing neurite elongation and migration. We demonstrate that inhibition of cytoplasmic JNK and expression of SCG10-62A/73A both inhibited fluorescent tubulin recovery after photobleaching. These data suggest that JNK1 is responsible for regulation of SCG10 depolymerizing activity and neurite elongation during brain development.

Published
2006

21. Correction to: Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy (Surgical Endoscopy, (2018), 10.1007/s00464-018-6281-2)

Author

Griffiths, Ewen A., Hodson, James, Vohra, Ravi S., Marriott, Paul, Katbeh, Tarek, Zino, Samer, Nassar, Ahmad H. M., Vohra, Ravinder S., Kirkham, Amanda J., Pasquali, Sandro, Johnstone, Marianne, Spreadborough, Philip, Alderson, Derek, Fenwick, Stephen, Elmasry, Mohamed, Nunes, Quentin M., Kennedy, David, Khan, Raja Basit, Khan, Muhammad A. S., Magee, Conor J., Jones, Steven M., Mason, Denise, Parappally, Ciny P., Mathur, Pawan, Saunders, Michael, Jamel, Sara, Haque, Samer Ul, Zafar, Sara, Shiwani, Muhammad Hanif, Samuel, Nehemiah, Dar, Farooq, Jackson, Andrew, Lovett, Bryony, Dindyal, Shiva, Winter, Hannah, Fletcher, Ted, Rahman, Saquib, Wheatley, Kevin, Nieto, Tom, Ayaani, Soofiyah, Youssef, Haney, Nijjar, Rajwinder S., Watkin, Helen, Naumann, David, Emesih, Sophie, Sarmah, Piyush B., Lee, Kathryn, Joji, Nikita, Lambert, Joel, Heath, Jonathan, Teasdale, Rebecca L., Weerasinghe, Chamindri, Needham, Paul J., Welbourn, Hannah, Forster, Luke, Finch, David, Blazeby, Jane M., Robb, William, Mcnair, Angus G. K., Hrycaiczuk, Alex, Charalabopoulos, Alexandros, Kadirkamanathan, Sritharan, Tang, Cheuk-Bong, Jayanthi, Naga V. G., Noor, Nigel, Dobbins, Brian, Cockbain, Andrew J., Nilsen-Nunn, April, de Siqueira, Jonathan, Pellen, Mike, Cowley, Jonathan B., Wei-Min, Ho, Miu, Victor, White, Timothy J., Hodgkins, Kathryn A., Kinghorn, Alison, Tutton, Matthew G., Al-Abed, Yahya A., Menzies, Donald, Ahmad, Anwar, Reed, Joanna, Khan, Shabuddin, Monk, David, Vitone, Louis J., Murtaza, Ghulam, Joel, Abraham, Brennan, Stephen, Shier, David, Zhang, Catherine, Yoganathan, Thusidaran, Robinson, Steven J., Mccallum, Iain J. D., Jones, Michael J., Elsayed, Mohammed, Tuck, Liz, Wayman, John, Carney, Kate, Aroori, Somaiah, Hosie, Kenneth B., Kimble, Adam, Bunting, David M., Fawole, Adeshina S., Basheer, Mohammed, Dave, Rajiv V., Sarveswaran, Janahan, Jones, Elinor, Kendal, Chris, Tilston, Michael P., Gough, Martin, Wallace, Tom, Singh, Shailendra, Mockford, Justine Downing Katherine A., Issa, Eyad, Shah, Nayab, Chauhan, Neal, Wilson, Timothy R., Forouzanfar, Amir, Wild, Jonathan R. L., Nofal, Emma, Bunnell, Catherine, Madbak, Khaliel, Rao, Sudhindra T. V., Devoto, Laurence, Siddiqi, Najaf, Khawaja, Zechan, Hewes, James C., Gould, Laura, Chambers, Alice, Rodriguez, Daniel Urriza, Sen, Gourab, Robinson, Stuart, Bartlett, Francis, Rae, David M., Stevenson, Thomas E. J., Sarvananthan, Kas, Dwerryhouse, Simon J., Higgs, Simon M., Old, Oliver J., Hardy, Thomas J., Hornby, Reena Shah Steve T., Keogh, Ken, Frank, Lucinda, Al-Akash, Musallam, Upchurch, Emma A., Frame, Richard J., Hughes, Michael, Jelley, Clare, Weaver, Simon, Roy, Sudipta, Sillo, Toritseju O., Galanopoulos, Giorgios, Cuming, Tamzin, Cunha, Pedro, Tayeh, Salim, Kaptanis, Sarantos, Heshaishi, Mohamed, Eisawi, Abdalla, Abayomi, Michael, Ngu, Wee Sing, Fleming, Katie, Bajwa, Dalvir S., Chitre, Vivek, Aryal, Kamal, Ferris, Paul, Silva, Michael, Mohamed, Simon Lammy Sarah, Khawaja, Amir, Hussain, Adnan, Ghazanfar, Mudassar A., Bellini, Maria Irene, Ebdewi, Hamdi, Elshaer, Mohamed, Gravante, Gianpiero, Drake, Benjamin, Ogedegbe, Arikoge, Mukherjee, Dipankar, Arhi, Chanpreet, Iqbal, Lola Giwa Nusrat, Watson, Nicholas F., Aggarwal, Smeer Kumar, Orchard, Philippa, Villatoro, Eduardo, Willson, Peter D., Mok, Kam Wa Jessica, Woodman, Thomas, Deguara, Jean, Garcea, Giuseppe, Babu, Benoy I., Dennison, A. R., Malde, Deep, Lloyd, David, Satheesan, Steve, Al-Taan, Omer, Boddy, Alexander, Slavin, John P., Jones, Robert P., Ballance, Laura, Gerakopoulos, Stratos, Jambulingam, Periyathambi, Mansour, Sami, Sakai, Naomi, Acharya, Vikas, Sadat, Mohammed M., Karim, Lawen, Larkin, David, Amin, Khalid, Khan, Amarah, Law, Jennifer, Jamdar, Saurabh, Smith, Stella R., Sampat, Keerthika, O’Shea, Kathryn M., Manu, Mangta, Asprou, Fotini M., Malik, Nabeela S., Chang, Jessica, Lewis, Michael, Roberts, Geoffrey P., Karavadra, Babu, Photi, Evangelos, Hewes, James, Rodriguez, Dan, O’Reilly, Derek A., Rate, Anthony J., Sekhar, Hema, Henderson, Lucy T., Starmer, Benjamin Z., Coe, Peter O., Tolofari, Sotonye, Barrie, Jenifer, Bashir, Gareth, Sloane, Jake, Madanipour, Suroosh, Halkias, Constantine, Trevatt, Alexander E. J., Borowski, David W., Hornsby, Jane, Courtney, Michael J., Virupaksha, Suvi, Seymour, Keith, Robinson, Sarah, Hawkins, Helen, Bawa, Sadiq, Gallagher, Paul V., Reid, Alistair, Wood, Peter, Finch, J. G., Guy Finch, J., Parmar, J., Stirland, E., Gardner-Thorpe, James, Al-Muhktar, Ahmed, Peterson, Mark, Majeed, Ali, Bajwa, Farrukh M., Martin, Jack, Choy, Alfred, Tsang, Andrew, Pore, Naresh, Andrew, David R., Al-Khyatt, Waleed, Bhandari, Christopher Taylor Santosh, Chambers, Adam, Subramanium, Dhivya, Toh, Simon K. C., Carter, Nicholas C., Tate, Sophie, Pearce, Belinda, Wainwright, Denise, Mercer, Stuart J., Knight, Benjamin, Vijay, Vardhini, Alagaratnam, Swethan, Sinha, Sidhartha, Khan, Shahab, El-Hasani, Shamsi S., Hussain, Abdulzahra A., Bhattacharya, Vish, Kansal, Nisheeth, Fasih, Tani, Jackson, Claire, Siddiqui, Midhat N., Chishti, Imran A., Fordham, Imogen J., Siddiqui, Zohaib, Bausbacher, Harald, Geogloma, Ileana, Gurung, Kabita, Tsavellas, George, Basynat, Pradeep, Shrestha, Ashish Kiran, Basu, Sanjoy, Harilingam, Alok Chhabra Mohan, Rabie, Mohamed, Akhtar, Mansoor, Kumar, Pradeep, Jafferbhoy, Sadaf F., Hussain, Najam, Raza, Soulat, Haque, Manzarul, Alam, Imran, Aseem, Rabiya, Patel, Shakira, Asad, Mehek, Booth, Michael I., Ball, William R., Wood, Christopher P. J., Pinho-Gomes, Ana C., Kausar, Ambareen, Obeidallah, Moh’d Rami, Varghase, Joseph, Lodhia, Joshil, Bradley, Donal, Rengifo, Carla, Lindsay, David, Gopalswamy, Sivakumar, Finlay, Ian, Wardle, Stacy, Bullen, Naomi, Iftikhar, Syed Yusuf, Awan, Altaf, Ahmed, Javed, Leeder, Paul, Fusai, Guiseppe, Bond-Smith, Giles, Psica, Alicja, Puri, Yogesh, Hou, David, Noble, Fergus, Szentpali, Karoly, Broadhurst, Jack, Date, Ravindra, Hossack, Martin R., Goh, Yan Li, Turner, Paul, Shetty, Vinutha, Riera, Manel, Macano, Christina A. W., Sukha, Anisha, Preston, Shaun R., Hoban, Jennifer R., Puntis, Daniel J., Williams, Sophie V., Krysztopik, Richard, Kynaston, James, Batt, Jeremy, Doe, Matthew, Goscimski, Andrzej, Jones, Gareth H., Hall, Claire, Carty, Nick, Ahmed, Jamil, Panteleimonitis, Sofoklis, Gunasekera, Rohan T., Sheel, Andrea R. G., Lennon, Hannah, Hindley, Caroline, Reddy, Marcus, Kenny, Ross, Elkheir, Natalie, Mcglone, Emma R., Rajaganeshan, Rajasundaram, Hancorn, Kate, Hargreaves, Anita, Prasad, Raj, Longbotham, David A., Vijayanand, Dhakshinamoorthy, Wijetunga, Imeshi, Ziprin, Paul, Nicolay, Christopher R., Yeldham, Geoffrey, Read, Edward, Gossage, James A., Rolph, Rachel C., Ebied, Husam, Phull, Manraj, Khan, Mohammad A., Popplewell, Matthew, Kyriakidis, Dimitrios, Hussain, Anwar, Henley, Natasha, Packer, Jessica R., Derbyshire, Laura, Porter, Jonathan, Appleton, Shaun, Farouk, Marwan, Basra, Melvinder, Jennings, Neil A., Ali, Shahda, Kanakala, Venkatesh, Ali, Haythem, Lane, Risha, Dickson-Lowe, Richard, Zarsadias, Prizzi, Mirza, Darius, Puig, Sonia, Amari, Khalid Al, Vijayan, Deepak, Sutcliffe, Robert, Marudanayagam, Ravi, Hamady, Zayed, Prasad, Abheesh R., Patel, Abhilasha, Durkin, Damien, Kaur, Parminder, Bowen, Laura, Byrne, James P., Pearson, Katherine L., Delisle, Theo G., Davies, James, Tomlinson, Mark A., Johnpulle, Michelle A., Slawinski, Corinna, Macdonald, Andrew, Nicholson, James, Newton, Katy, Mbuvi, James, Farooq, Ansar, Mothe, Bhavani Sidhartha, Zafrani, Zakhi, Brett, Daniel, Francombe, James, Barnes, James, Cheung, Melanie, Al-Bahrani, Ahmed Z., Preziosi, Giuseppe, Urbonas, Tomas, Alberts, Justin, Mallik, Mekhlola, Patel, Krashna, Segaran, Ashvina, Doulias, Triantafyllos, Sufi, Pratik A., Yao, Caroline, Pollock, Sarah, Manzelli, Antonio, Wajed, Saj, Kourkulos, Michail, Pezzuto, Roberto, Wadley, Martin, Hamilton, Emma, Jaunoo, Shameen, Padwick, Robert, Sayegh, Mazin, Newton, Richard C., Hebbar, Madhusoodhana, Farag, Sameh F., Spearman, John, Hamdan, Mohammed F., D’Costa, Conrad, Blane, Christine, Giles, Mathew, Peter, Mark B., Hirst, Natalie A., Hossain, Tanvir, El-Dhuwaib, Arslan Pannu Yesar, Morrison, Tamsin E. M., Taylor, Greg W., Thompson, Ronald L. E., Mccune, Ken, Loughlin, Paula, Lawther, Roger, Byrnes, Colman K., Simpson, Duncan J., Mawhinney, Abi, Warren, Conor, Mckay, Damian, Mcilmunn, Colin, Martin, Serena, Macartney, Matthew, Diamond, Tom, Davey, Phil, Jones, Claire, Clements, Joshua M., Digney, Ruairi, Chan, Wei Ming, Mccain, Stephen, Gull, Sadaf, Janeczko, Adam, Dorrian, Emmet, Harris, Andrew, Dawson, Suzanne, Johnston, Dorothy, Mcaree, Barry, Ghareeb, Essam, Thomas, George, Connelly, Martin, Mckenzie, Stephen, Cieplucha, Krzysztos, Spence, Gary, Campbell, William, Hooks, Gareth, Bradley, Neil, Hill, Arnold D. K., Cassidy, John T., Boland, Michael, Burke, Paul, Nally, Deirdre M., Khogali, Elmoataz, Shabo, Wael, Iskandar, Edrin, Mcentee, Gerry P., O’Neill, Maeve A., Peirce, Colin, Lyons, Emma M., O’Sullivan, Adrian W., Thakkar, Rohan, Carroll, Paul, Ivanovski, Ivan, Balfe, Paul, Lee, Matthew, Winter, Des C., Kelly, Michael E., Hoti, Emir, Maguire, Donal, Karunakaran, Priyadarssini, Geoghegan, Justin G., Mcdermott, Frank, Martin, Sean T., Cross, Keith S., Cooke, Fiachra, Zeeshan, Saquib, Murphy, James O., Mealy, Ken, Mohan, Helen M., Nedujchelyn, Yuwaraja, Ullah, Muhammad Fahad, Ahmed, Irfan, Giovinazzo, Francesco, Milburn, James, Prince, Sarah, Brooke, Eleanor, Buchan, Joanna, Khalil, Ahmed M., Vaughan, Elizabeth M., Ramage, Michael I., Aldridge, Roland C., Gibson, Simon, Nicholson, Gary A., Vass, David G., Grant, Alan J., Holroyd, David J., Angharad Jones, M., Sutton, Cherith M. L. R., O’Dwyer, Patrick, Nilsson, Frida, Weber, Beatrix, Williamson, Tracey K., Lalla, Kushik, Bryant, Alice, Ross Carter, C., Forrest, Craig R., Hunter, David I., Nassar, Ahmad H., Orizu, Mavis N., Knight, Katrina, Qandeel, Haitham, Suttie, Stuart, Belding, Rowena, Mcclarey, Andrew, Boyd, Alan T., Guthrie, Graeme J. K., Lim, Pei J., Luhmann, Andreas, Watson, Angus J. M., Richards, Colin H., Nicol, Laura, Madurska, Marta, Harrison, Ewen, Boyce, Kathryn M., Roebuck, Amanda, Ferguson, Graeme, Pati, Pradeep, Wilson, Michael S. J., Dalgaty, Faith, Fothergill, Laura, Driscoll, Peter J., Mozolowski, Kirsty L., Banwell, Victoria, Bennett, Stephen P., Rogers, Paul N., Skelly, Brendan L., Rutherford, Claire L., Mirza, Ahmed K., Lazim, Taha, Lim, Henry C. C., Duke, Diana, Ahmed, Talat, Beasley, William D., Wilkinson, Marc D., Maharaj, Geta, Malcolm, Cathy, Brown, Timothy H., Al-Sarireh, Bilal, Shingler, Guy M., Mowbray, Nicholas, Radwan, Rami, Morcous, Paul, Wood, Simon, Kadhim, Abbas, Stewart, Duncan J., Baker, Andrew L., Tanner, Nicola, Shenoy, Hrishikesh, Hafiz, Shazia, De Marchi, Joshua A., Singh-Ranger, Deepak, Hisham, Elzanati, Ainley, Paul, John Terrace, Stephen O’Neill., Napetti, Sara, Hopwood, Benjamin, Rhys, Thomas, Downing, Justine, Kanavati, Osama, Coats, Maria, Aleksandrov, Danail, Kallaway, Charlotte, Yahya, Salama, Templeton, Alexa, Trotter, Martin, Christina, Lo, Dhillon, Ajit, Heywood, Nick, Aawsaj, Yousif, Hamdan, Alhafidz, Reece-Bolton, Obuobi, Mcguigan, Andrew, Shahin, Yousef, Aymon, Null, Luther, Ali Alison, Nicholson, James A., Rajendran, Ilayaraja, Boal, Matthew, and Ritchie, Judith

Subjects
Surgery
Published
2018

25. F193. Overexpression of NOS1AP in Dorsal Hippocampus and Medial Prefrontal Cortex Induces Schizophrenia-Related Phenotypic Changes

Author

Candemir, Esin, primary, Fattakhov, Nikolai, additional, Li, Li-Li, additional, Chen, Xufeng, additional, Esen, Dilhan, additional, Frerichs, Veronika, additional, Arshad, Saleha, additional, Grünewald, Lena, additional, O'Leary, Aet, additional, Slattery, David A., additional, von Engelhardt, Jakob, additional, Courtney, Michael J., additional, Reif, Andreas, additional, and Freudenberg, Florian, additional

Published
2018
Full Text
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33. Preoperative risk factors for conversion from laparoscopic to open cholecystectomy: a validated risk score derived from a prospective U.K. database of 8820 patients

Author

Sutcliffe, Robert P., primary, Hollyman, Marianne, additional, Hodson, James, additional, Bonney, Glenn, additional, Vohra, Ravi S., additional, Griffiths, Ewen A., additional, Fenwick, Stephen, additional, Elmasry, Mohamed, additional, Nunes, Quentin, additional, Kennedy, David, additional, Khan, Raja B., additional, Khan, Muhammad A.S., additional, Magee, Conor J., additional, Jones, Steven M., additional, Mason, Denise, additional, Parappally, Ciny P., additional, Mathur, Pawan, additional, Saunders, Michael, additional, Jamel, Sara, additional, Haque, Samer U.l., additional, Zafar, Sara, additional, Shiwani, Muhammad H., additional, Samuel, Nehemiah, additional, Dar, Farooq, additional, Jackson, Andrew, additional, Lovett, Bryony, additional, Dindyal, Shiva, additional, Winter, Hannah, additional, Rahman, Saquib, additional, Wheatley, Kevin, additional, Nieto, Tom, additional, Ayaani, Soofiyah, additional, Youssef, Haney, additional, Nijjar, Rajwinder S., additional, Watkin, Helen, additional, Naumann, David, additional, Emeshi, Sophie, additional, Sarmah, Piyush B., additional, Lee, Kathryn, additional, Joji, Nikita, additional, Heath, Jonathan, additional, Teasdale, Rebecca L., additional, Weerasinghe, Chamindri, additional, Needham, Paul J., additional, Welbourn, Hannah, additional, Forster, Luke, additional, Finch, David, additional, Blazeby, Jane M., additional, Robb, William, additional, McNair, Angus G.K., additional, Hrycaiczuk, Alex, additional, Charalabopoulos, Alexandros, additional, Kadirkamanathan, Sritharan, additional, Tang, Cheuk-Bong, additional, Jayanthi, Naga V.G., additional, Noor, Nigel, additional, Dobbins, Brian, additional, Cockbain, Andrew J., additional, Nilsen-Nunn, April, additional, de Siqueira, Jonathan, additional, Pellen, Mike, additional, Cowley, Jonathan B., additional, Ho, Wei-Min, additional, Miu, Victor, additional, White, Timothy J., additional, Hodgkins, Kathryn A., additional, Kinghorn, Alison, additional, Tutton, Matthew G., additional, Al-Abed, Yahya A., additional, Menzies, Donald, additional, Ahmad, Anwar, additional, Reed, Joanna, additional, Khan, Shabuddin, additional, Monk, David, additional, Vitone, Louis J., additional, Murtaza, Ghulam, additional, Joel, Abraham, additional, Brennan, Stephen, additional, Shier, David, additional, Zhang, Catherine, additional, Yoganathan, Thusidaran, additional, Robinson, Steven J., additional, McCallum, Iain J.D., additional, Jones, Michael J., additional, Elsayed, Mohammed, additional, Tuck, Liz, additional, Wayman, John, additional, Carney, Kate, additional, Aroori, Somaiah, additional, Hosie, Kenneth B., additional, Kimble, Adam, additional, Bunting, David M., additional, Fawole, Adeshina S., additional, Basheer, Mohammed, additional, Dave, Rajiv V., additional, Sarveswaran, Janahan, additional, Jones, Elinor, additional, Kendal, Chris, additional, Tilston, Michael P., additional, Gough, Martin, additional, Wallace, Tom, additional, Singh, Shailendra, additional, Downing, Justine, additional, Mockford, Katherine A., additional, Issa, Eyad, additional, Shah, Nayab, additional, Chauhan, Neal, additional, Wilson, Timothy R., additional, Forouzanfar, Amir, additional, Wild, Jonathan R.L., additional, Nofal, Emma, additional, Bunnell, Catherine, additional, Madbak, Khaliel, additional, Rao, Sudhindra T.V., additional, Devoto, Laurence, additional, Siddiqi, Najaf, additional, Khawaja, Zechan, additional, Hewes, James C., additional, Gould, Laura, additional, Chambers, Alice, additional, Rodriguez, Daniel U., additional, Sen, Gourab, additional, Robinson, Stuart, additional, Bartlett, Francis, additional, Rae, David M., additional, Stevenson, Thomas E.J., additional, Sarvananthan, Kas, additional, Dwerryhouse, Simon J., additional, Higgs, Simon M., additional, Old, Oliver J., additional, Hardy, Thomas J., additional, Shah, Reena, additional, Hornby, Steve T., additional, Keogh, Ken, additional, Frank, Lucinda, additional, Al-Akash, Musallam, additional, Upchurch, Emma A., additional, Frame, Richard J., additional, Hughes, Michael, additional, Jelley, Clare, additional, Weaver, Simon, additional, Roy, Sudipta, additional, Sillo, Toritseju O., additional, Galanopoulos, Giorgios, additional, Cuming, Tamzin, additional, Cunha, Pedro, additional, Tayeh, Salim, additional, Kaptanis, Sarantos, additional, Heshaishi, Mohamed, additional, Eisawi, Abdalla, additional, Abayomi, Michael, additional, Ngu, Wee S., additional, Fleming, Katie, additional, Bajwa, Dalvir S., additional, Chitre, Vivek, additional, Aryal, Kamal, additional, Ferris, Paul, additional, Silva, Michael, additional, Lammy, Simon, additional, Mohamed, Sarah, additional, Khawaja, Amir, additional, Hussain, Adnan, additional, Ghazanfar, Mudassar A., additional, Bellini, Maria I., additional, Ebdewi, Hamdi, additional, Elshaer, Mohamed, additional, Gravante, Gianpiero, additional, Drake, Benjamin, additional, Ogedegbe, Arikoge, additional, Mukherjee, Dipankar, additional, Arhi, Chanpreet, additional, Giwa, Lola, additional, Iqbal, Nusrat, additional, Watson, Nicholas F., additional, Aggarwal, Smeer K., additional, Orchard, Philippa, additional, Villatoro, Eduardo, additional, Willson, Peter D., additional, Mok, Kam W.J., additional, Woodman, Thomas, additional, Deguara, Jean, additional, Garcea, Giuseppe, additional, Babu, Benoy I., additional, Dennison, Alistair R., additional, Malde, Deep, additional, Lloyd, David, additional, Slavin, John P., additional, Jones, Robert P., additional, Ballance, Laura, additional, Gerakopoulos, Stratos, additional, Jambulingam, Periyathambi, additional, Mansour, Sami, additional, Sakai, Naomi, additional, Acharya, Vikas, additional, Sadat, Mohammed M., additional, Karim, Lawen, additional, Larkin, David, additional, Amin, Khalid, additional, Khan, Amarah, additional, Law, Jennifer, additional, Jamdar, Saurabh, additional, Smith, Stella R., additional, Sampat, Keerthika, additional, O'shea, Kathryn M., additional, Manu, Mangta, additional, Asprou, Fotini M., additional, Malik, Nabeela S., additional, Chang, Jessica, additional, Johnstone, Marianne, additional, Lewis, Michael, additional, Roberts, Geoffrey P., additional, Karavadra, Babu, additional, Photi, Evangelos, additional, Hewes, James, additional, Rodriguez, Dan, additional, O'Reilly, Derek A., additional, Rate, Anthony J., additional, Sekhar, Hema, additional, Henderson, Lucy T., additional, Starmer, Benjamin Z., additional, Coe, Peter O., additional, Tolofari, Sotonye, additional, Barrie, Jenifer, additional, Bashir, Gareth, additional, Sloane, Jake, additional, Madanipour, Suroosh, additional, Halkias, Constantine, additional, Trevatt, Alexander E.J., additional, Borowski, David W., additional, Hornsby, Jane, additional, Courtney, Michael J., additional, Virupaksha, Suvi, additional, Seymour, Keith, additional, Robinson, Sarah, additional, Hawkins, Helen, additional, Bawa, Sadiq, additional, Gallagher, Paul V., additional, Reid, Alistair, additional, Wood, Peter, additional, Finch, Jonathan G., additional, Finch, J.Guy, additional, Parmar, Jitesh, additional, Stirland, Euan, additional, Gardner-Thorpe, James, additional, Al-Muhktar, Ahmed, additional, Peterson, Mark, additional, Majeed, Ali, additional, Bajwa, Farrukh M., additional, Martin, Jack, additional, Choy, Alfred, additional, Tsang, Andrew, additional, Pore, Naresh, additional, Andrew, David R., additional, Al-Khyatt, Waleed, additional, Santosh Bhandari, Christopher Taylor, additional, Chambers, Adam, additional, Subramanium, Dhivya, additional, Toh, Simon K.C., additional, Carter, Nicholas C., additional, Mercer, Stuart J., additional, Knight, Benjamin, additional, Vijay, Vardhini, additional, Alagaratnam, Swethan, additional, Sinha, Sidhartha, additional, Khan, Shahab, additional, El-Hasani, Shamsi S., additional, Hussain, Abdulzahra A., additional, Bhattacharya, Vish, additional, Kansal, Nisheeth, additional, Fasih, Tani, additional, Jackson, Claire, additional, Siddiqui, Midhat N., additional, Chishti, Imran A., additional, Fordham, Imogen J., additional, Siddiqui, Zohaib, additional, Bausbacher, Harald, additional, Geogloma, Ileana, additional, Gurung, Kabita, additional, Tsavellas, George, additional, Basynat, Pradeep, additional, Shrestha, Ashish K., additional, Basu, Sanjoy, additional, Chhabra, Alok, additional, Harilingam, Mohan, additional, Rabie, Mohamed, additional, Akhtar, Mansoor, additional, Kumar, Pradeep, additional, Jafferbhoy, Sadaf F., additional, Hussain, Najam, additional, Raza, Soulat, additional, Haque, Manzarul, additional, Alam, Imran, additional, Aseem, Rabiya, additional, Patel, Shakira, additional, Asad, Mehek, additional, Booth, Michael I., additional, Ball, William R., additional, Wood, Christopher P.J., additional, Pinho-Gomes, Ana C., additional, Kausar, Ambareen, additional, Obeidallah, Mohammed, additional, Varghase, Joseph, additional, Lodhia, Joshil, additional, Bradley, Donal, additional, Rengifo, Carla, additional, Lindsay, David, additional, Gopalswamy, Sivakumar, additional, Finlay, Ian, additional, Wardle, Stacy, additional, Bullen, Naomi, additional, Iftikhar, Syed Y., additional, Awan, Altaf, additional, Ahmed, Javed, additional, Leeder, Paul, additional, Fusai, Guiseppe, additional, Bond-Smith, Giles, additional, Psica, Alicja, additional, Puri, Yogesh, additional, Hou, David, additional, Noble, Fergus, additional, Szentpali, Karoly, additional, Broadhurst, Jack, additional, Date, Ravindra, additional, Hossack, Martin R., additional, Goh, Yan L., additional, Turner, Paul, additional, Shetty, Vinutha, additional, Riera, Manel, additional, Macano, Christina A.W., additional, Sukha, Anisha, additional, Preston, Shaun R., additional, Hoban, Jennifer R., additional, Puntis, Daniel J., additional, Williams, Sophie V., additional, Krysztopik, Richard, additional, Kynaston, James, additional, Batt, Jeremy, additional, Doe, Matthew, additional, Goscimski, Andrzej, additional, Jones, Gareth H., additional, Hall, Claire, additional, Carty, Nick, additional, Ahmed, Jamil, additional, Panteleimonitis, Sofoklis, additional, Gunasekera, Rohan T., additional, Sheel, Andrea R.G., additional, Lennon, Hannah, additional, Hindley, Caroline, additional, Reddy, Marcus, additional, Kenny, Ross, additional, Elkheir, Natalie, additional, McGlone, Emma R., additional, Rajaganeshan, Rajasundaram, additional, Hancorn, Kate, additional, Hargreaves, Anita, additional, Prasad, Raj, additional, Longbotham, David A., additional, Vijayanand, Dhakshinamoorthy, additional, Wijetunga, Imeshi, additional, Ziprin, Paul, additional, Nicolay, Christopher R., additional, Yeldham, Geoffrey, additional, Read, Edward, additional, Gossage, James A., additional, Rolph, Rachel C., additional, Ebied, Husam, additional, Phull, Manraj, additional, Khan, Mohammad A., additional, Popplewell, Matthew, additional, Kyriakidis, Dimitrios, additional, Hussain, Anwar, additional, Henley, Natasha, additional, Packer, Jessica R., additional, Derbyshire, Laura, additional, Porter, Jonathan, additional, Appleton, Shaun, additional, Farouk, Marwan, additional, Basra, Melvinder, additional, Jennings, Neil A., additional, Ali, Shahda, additional, Kanakala, Venkatesh, additional, Ali, Haythem, additional, Lane, Risha, additional, Dickson-Lowe, Richard, additional, Zarsadias, Prizzi, additional, Mirza, Darius, additional, Puig, Sonia, additional, Al Amari, Khalid, additional, Vijayan, Deepak, additional, Sutcliffe, Robert, additional, Marudanayagam, Ravi, additional, Hamady, Zayed, additional, Prasad, Abheesh R., additional, Patel, Abhilasha, additional, Durkin, Damien, additional, Kaur, Parminder, additional, Bowen, Laura, additional, Byrne, James P., additional, Pearson, Katherine L., additional, Delisle, Theo G., additional, Davies, James, additional, Tomlinson, Mark A., additional, Johnpulle, Michelle A., additional, Slawinski, Corinna, additional, Macdonald, Andrew, additional, Nicholson, James, additional, Newton, Katy, additional, Mbuvi, James, additional, Farooq, Ansar, additional, Mothe, Bhavani S., additional, Zafrani, Zakhi, additional, Brett, Daniel, additional, Francombe, James, additional, Spreadborough, Philip, additional, Barnes, James, additional, Cheung, Melanie, additional, Al-Bahrani, Ahmed Z., additional, Preziosi, Giuseppe, additional, Urbonas, Tomas, additional, Alberts, Justin, additional, Mallik, Mekhlola, additional, Patel, Krashna, additional, Segaran, Ashvina, additional, Doulias, Triantafyllos, additional, Sufi, Pratik A., additional, Yao, Caroline, additional, Pollock, Sarah, additional, Manzelli, Antonio, additional, Wajed, Saj, additional, Kourkulos, Michail, additional, Pezzuto, Roberto, additional, Wadley, Martin, additional, Hamilton, Emma, additional, Jaunoo, Shameen, additional, Padwick, Robert, additional, Sayegh, Mazin, additional, Newton, Richard C., additional, Hebbar, Madhusoodhana, additional, Farag, Sameh F., additional, Hebbar, Madhu, additional, Spearman, John, additional, Hamdan, Mohammed F., additional, D'Costa, Conrad, additional, Blane, Christine, additional, Giles, Mathew, additional, Peter, Mark B., additional, Hirst, Natalie A., additional, Hossain, Tanvir, additional, Pannu, Arslan, additional, El-Dhuwaib, Yesar, additional, Morrison, Tamsin E.M., additional, Taylor, Greg W., additional, Thompson, Ronald L.E., additional, McCune, Ken, additional, Loughlin, Paula, additional, Lawther, Roger, additional, Byrnes, Colman K., additional, Simpson, Duncan J., additional, Mawhinney, Abi, additional, Warren, Conor, additional, McKay, Damian, additional, McIlmunn, Colin, additional, Martin, Serena, additional, MacArtney, Matthew, additional, Diamond, Tom, additional, Davey, Phil, additional, Jones, Claire, additional, Clements, Joshua M., additional, Digney, Ruairi, additional, Chan, Wei M., additional, McCain, Stephen, additional, Gull, Sadaf, additional, Janeczko, Adam, additional, Dorrian, Emmet, additional, Harris, Andrew, additional, Dawson, Suzanne, additional, Johnston, Dorothy, additional, McAree, Barry, additional, Ghareeb, Essam, additional, Thomas, George, additional, Connelly, Martin, additional, McKenzie, Stephen, additional, Cieplucha, Krzysztos, additional, Spence, Gary, additional, Campbell, William, additional, Hooks, Gareth, additional, Bradley, Neil, additional, Hill, Arnold D.K., additional, Cassidy, John T., additional, Boland, Michael, additional, Burke, Paul, additional, Nally, Deirdre M., additional, Khogali, Elmoataz, additional, Shabo, Wael, additional, Iskandar, Edrin, additional, McEntee, Gerry P., additional, O'Neill, Maeve A., additional, Peirce, Colin, additional, Lyons, Emma M., additional, O'Sullivan, Adrian W., additional, Thakkar, Rohan, additional, Carroll, Paul, additional, Ivanovski, Ivan, additional, Balfe, Paul, additional, Lee, Matthew, additional, Winter, Des C., additional, Kelly, Michael E., additional, Hoti, Emir, additional, Maguire, Donal, additional, Karunakaran, Priyadarssini, additional, Geoghegan, Justin G., additional, Martin, Sean T., additional, Cross, Keith S., additional, Cooke, Fiachra, additional, Zeeshan, Saquib, additional, Murphy, James O., additional, Mealy, Ken, additional, Mohan, Helen M., additional, Nedujchelyn, Yuwaraja, additional, Ullah, Muhammad F., additional, Ahmed, Irfan, additional, Giovinazzo, Francesco, additional, Milburn, James, additional, Prince, Sarah, additional, Brooke, Eleanor, additional, Buchan, Joanna, additional, Khalil, Ahmed M., additional, Vaughan, Elizabeth M., additional, Ramage, Michael I., additional, Aldridge, Roland C., additional, Gibson, Simon, additional, Nicholson, Gary A., additional, Vass, David G., additional, Grant, Alan J., additional, Holroyd, David J., additional, Jones, Angharad, additional, Sutton, Cherith M.L.R., additional, O'Dwyer, Patrick, additional, Nilsson, Frida, additional, Weber, Beatrix, additional, Williamson, Tracey K., additional, Lalla, Kushik, additional, Bryant, Alice, additional, Carter, Ross, additional, Forrest, Craig R., additional, Hunter, David I., additional, Nassar, Ahmad H., additional, Orizu, Mavis N., additional, Knight, Katrina, additional, Qandeel, Haitham, additional, Suttie, Stuart, additional, Belding, Rowena, additional, McClarey, Andrew, additional, Boyd, Alan T., additional, Guthrie, Graeme J.K., additional, Lim, Pei J., additional, Luhmann, Andreas, additional, Watson, Angus J.M., additional, Richards, Colin H., additional, Nicol, Laura, additional, Madurska, Marta, additional, Harrison, Ewen, additional, Boyce, Kathryn M., additional, Roebuck, Amanda, additional, Ferguson, Graeme, additional, Pati, Pradeep, additional, Wilson, Michael S.J., additional, Dalgaty, Faith, additional, Fothergill, Laura, additional, Driscoll, Peter J., additional, Mozolowski, Kirsty L., additional, Banwell, Victoria, additional, Bennett, Stephen P., additional, Rogers, Paul N., additional, Skelly, Brendan L., additional, Rutherford, Claire L., additional, Mirza, Ahmed K., additional, Lazim, Taha, additional, Lim, Henry C.C., additional, Duke, Diana, additional, Ahmed, Talat, additional, Beasley, William D., additional, Wilkinson, Marc D., additional, Maharaj, Geta, additional, Malcolm, Cathy, additional, Brown, Timothy H., additional, Shingler, Guy M., additional, Mowbray, Nicholas, additional, Radwan, Rami, additional, Morcous, Paul, additional, Wood, Simon, additional, Kadhim, Abbas, additional, Stewart, Duncan J., additional, Baker, Andrew L., additional, Tanner, Nicola, additional, and Shenoy, Hrishikesh, additional

Published
2016
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35. Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models

Author

Li, Lili, De Mera, Raquel M. Melero-Fernandez, Chen, Jia, Ba, Wei, Kasri, Nael Nadif, Zhang, Mingjie, Courtney, Michael J., Li, Lili, De Mera, Raquel M. Melero-Fernandez, Chen, Jia, Ba, Wei, Kasri, Nael Nadif, Zhang, Mingjie, and Courtney, Michael J.

Abstract

The protein NOS1AP/CAPON mediates signaling from a protein complex of NMDA receptor, PSD95 and nNOS. The only stroke trial for neuroprotectants that showed benefit to patients targeted this ternary complex. NOS1AP/nNOS interaction regulates small GTPases, iron transport, p38MAPK-linked excitotoxicity, and anxiety. Moreover, the nos1ap gene is linked to disorders from schizophrenia, post-traumatic stress disorder, and autism to cardiovascular disorders and breast cancer. Understanding protein interactions required for NOS1AP function, therefore, has broad implications for numerous diseases. Here we show that the interaction of NOS1AP with nNOS differs radically from the classical PDZ docking assumed to be responsible. The NOS1AP PDZ motif does not bind nNOS as measured by multiple methods. In contrast, full-length NOS1AP forms an unusually stable interaction with nNOS. We mapped the discrepancy between full-length and C-terminal PDZ motif to a novel internal region we call the ExF motif. The C-terminal PDZ motif, although neither sufficient nor necessary for binding, nevertheless promotes the stability of the complex. It therefore potentially affects signal transduction and suggests that functional interaction of nNOS with NOS1AP might be targetable at two distinct sites. We demonstrate that excitotoxic pathways can be regulated, in cortical neuron and organotypic hippocampal slice cultures from rat, either by the previously described PDZ ligand TAT-GESV or by the ExF motif-bearing region of NOS1AP, even when lacking the critical PDZ residues as long as the ExF motif is intact and not mutated. This previously unrecognized heterodivalent interaction of nNOS with NOS1AP may therefore provide distinct opportunities for pharmacological intervention in NOS1AP-dependent signaling and excitotoxicity.

Published
2015

36. ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOSI AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.

Author

Wan-Hung Lee, Hohmann, Andrea G., Carey, Lawrence M., Zhili Xu, Lai, Yvonne Y., Li-Li Li, and Courtney, Michael J.

Subjects
METHYL aspartate receptors, PROTEIN-protein interactions, NITRIC oxide, POSTSYNAPTIC density protein, DRUG development
Abstract

Elevated N-methyl-D-aspartate receptor activity contributes to central sensitization. Our laboratories and others recently reported that disrupting protein-protein interactions downstream of N-methyl-D-aspartate receptors suppresses pain. Specifically, disrupting binding between the enzyme neuronal nitric oxide synthase and either its upstream (postsynaptic density 95 kDa, PSD95) or downstream (e.g. nitric oxide synthase 1 adaptor protein, NOS1AP) protein partners suppressed inflammatory and/or neuropathic pain. However, the lack of a small-molecule neuronal nitric oxide synthase-NOS1AP inhibitor has hindered efforts to validate the therapeutic utility of disrupting the neuronal nitric oxide synthase-NOS1AP interface as an analgesic strategy. We, therefore, evaluated the ability of a putative small-molecule neuronal nitric oxide synthase-NOS1AP inhibitor ZLc002 to disrupt binding between neuronal nitric oxide synthase and NOS1AP using ex vivo, in vitro, and purified recombinant systems and asked whether ZLc002 would suppress inflammatory and neuropathic pain in vivo. In vitro, ZLc002 reduced co-immunoprecipitation of full-length NOS1AP and neuronal nitric oxide synthase in cultured neurons and in HEK293T cells co-expressing full-length neuronal nitric oxide synthase and NOS1AP. However, using a cellfree biochemical binding assay, ZLc002 failed to disrupt the in vitro binding between His-neuronal nitric oxide synthase1-299 and glutathione S-transferase-NOS1AP400-506, protein sequences containing the required binding domains for this protein-protein interaction, suggesting an indirect mode of action in intact cells. ZLc002 (4-10mg/kg i.p.) suppressed formalinevoked inflammatory pain in rats and reduced Fos protein-like immunoreactivity in the lumbar spinal dorsal horn. ZLc002 also suppressed mechanical and cold allodynia in a mouse model of paclitaxel-induced neuropathic pain. Anti-allodynic efficacy was sustained for at least four days of once daily repeated dosing. ZLc002 also synergized with paclitaxel when administered in combination to reduce breast (4T1) or ovarian (HeyA8) tumor cell line viability but did not alter tumor cell viability without paclitaxel. Our results verify that ZLc002 disrupts neuronal nitric oxide synthase-NOS1AP interaction in intact cells and demonstrate, for the first time, that systemic administration of a putative small-molecule inhibitor of neuronal nitric oxide synthase-NOS1AP suppresses inflammatory and neuropathic pain. [ABSTRACT FROM AUTHOR]

Published
2018
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41. Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate

Author

Westerlund, Nina, Zdrojewska, Justyna, Padzik, Artur, Komulainen, Emilia, Björkblom, Benny, Rannikko, Emmy, Tararuk, Tanya, Garcia-Frigola, Cristina, Sandholm, Jouko, Nguyen, Laurent, Kallunki, Tuula, Courtney, Michael J, Coffey, Eleanor T, Westerlund, Nina, Zdrojewska, Justyna, Padzik, Artur, Komulainen, Emilia, Björkblom, Benny, Rannikko, Emmy, Tararuk, Tanya, Garcia-Frigola, Cristina, Sandholm, Jouko, Nguyen, Laurent, Kallunki, Tuula, Courtney, Michael J, and Coffey, Eleanor T

Abstract

Cell migration is the consequence of the sum of positive and negative regulatory mechanisms. Although appropriate migration of neurons is a principal feature of brain development, the negative regulatory mechanisms remain obscure. We found that JNK1 was highly active in developing cortex and that selective inhibition of JNK in the cytoplasm markedly increased both the frequency of exit from the multipolar stage and radial migration rate and ultimately led to an ill-defined cellular organization. Moreover, regulation of multipolar-stage exit and radial migration in Jnk1−/− (also known as Mapk8) mice, resulted from consequential changes in phosphorylation of the microtubule regulator SCG10 (also called stathmin-2). Expression of an SCG10 mutant that mimics the JNK1-phosphorylated form restored normal migration in the brains of Jnk1−/− mouse embryos. These findings indicate that the phosphorylation of SCG10 by JNK1 is a fundamental mechanism that governs the transition from the multipolar stage and the rate of neuronal cell movement during cortical development.

Published
2011
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42. Concurrent protective and destructive signaling of JNK2 in neuroblastoma cells

Author

Waetzig, Vicki, Wacker, Ute, Haeusgen, Wiebke, Björkblom, Benny, Courtney, Michael J., Coffey, Eleanor T., Herdegen, Thomas, Waetzig, Vicki, Wacker, Ute, Haeusgen, Wiebke, Björkblom, Benny, Courtney, Michael J., Coffey, Eleanor T., and Herdegen, Thomas

Abstract

Investigation of the c-Jun N-terminal kinases (JNKs) has mainly focused on their response to stress and their pro-apoptotic effects. In this regard, JNKs are crucial mediators of chemotherapy-induced killing of tumor cells. Importantly, however, JNKs also have physiological functions in cancer involving cell cycle regulation or oncogenesis. Hypothetically, the composition of JNK signalosomes determines the signaling outcome which, in turn, implies a multitude of different, sometimes opposing and interfering functions. In the present study, the well-characterized human neuroblastoma cell line SH-SY5Y served as a model system to separate physiological and pro-apoptotic JNK actions in the response to the cytoskeleton-interfering substances colchicine, cytochalasin D and taxol. Basically, JNKs mediated both cell death and proliferation. Using the chemical JNK inhibitor SP600125 as well as compartment-specific JNK-inhibiting constructs and dominant-negative isoform mutants, we show that the nuclear subgroup of JNK2 is the dominant effector in colchicine- and taxol-induced apoptosis, while cell cycle promotion is mediated by both cytoplasmic and nuclear JNK2. In contrast, cytochalasin D-triggered apoptosis is independent of JNK signaling. Interestingly, the data of the present study demonstrate for the first time that both cell protective (cell cycle progression) and destructive mechanisms (apoptosis) are simultaneously controlled by a single JNK isoform in the same cell system even under the influence of one stimulus. This has implications for the therapeutic application of JNK inhibitors and cytoskeleton-interfering substances in oncologic disorders.

Published
2009
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43. All JNKs Can Kill, but Nuclear Localization Is Critical for Neuronal Death

Author

Björkblom, Benny, Vainio, Jenni C., Hongisto, Vesa, Herdegen, Thomas, Courtney, Michael J., Coffey, Eleanor T., Björkblom, Benny, Vainio, Jenni C., Hongisto, Vesa, Herdegen, Thomas, Courtney, Michael J., and Coffey, Eleanor T.

Abstract

JNKs are implicated in a range of brain pathologies and receive considerable attention as potential therapeutic targets. However, JNKs also regulate physiological and homeostatic processes. An attractive hypothesis from the drug development perspective is that distinct JNK isoforms mediate “physiological” and “pathological” responses. However, this lacks experimental evaluation. Here we investigate the isoforms, subcellular pools, and c-Jun/ATF2 targets of JNK in death of central nervous system neurons following withdrawal of trophic support. We use gene knockouts, gene silencing, subcellularly targeted dominant negative constructs, and pharmacological inhibitors. Combined small interfering RNA knockdown of all JNKs 1, 2, and 3, provides substantial neuroprotection. In contrast, knockdown or knock-out of individual JNKs or two JNKs together does not protect. This explains why the evidence for JNK in neuronal death has to date been largely pharmacological. Complete knockdown of c-Jun and ATF2 using small interfering RNA also fails to protect, casting doubt on c-Jun as a critical effector of JNK in neuronal death. Nonetheless, the death requires nuclear but not cytosolic JNK activity as nuclear dominant negative inhibitors of JNK protect, whereas cytosolic inhibitors only block physiological JNK function. Thus any one of the three JNKs is capable of mediating apoptosis and inhibition of nuclear JNK is protective.

Published
2008
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45. Constitutively Active Cytoplasmic c-Jun N-Terminal Kinase 1 Is a Dominant Regulator of Dendritic Architecture: Role of Microtubule-Associated Protein 2 as an Effector

Author

Björkblom, Benny, Östman, Nina, Hongisto, Vesa, Komarovski, Vladislav, Filén, Jan-Jonas, Nyman, Tuula A., Kallunki, Tuula, Courtney, Michael J., Coffey, Eleanor T., Björkblom, Benny, Östman, Nina, Hongisto, Vesa, Komarovski, Vladislav, Filén, Jan-Jonas, Nyman, Tuula A., Kallunki, Tuula, Courtney, Michael J., and Coffey, Eleanor T.

Abstract

Normal functioning of the nervous system requires precise regulation of dendritic shape and synaptic connectivity. Here, we report a severe impairment of dendritic structures in the cerebellum and motor cortex of c-Jun N-terminal kinase 1 (JNK1)-deficient mice. Using an unbiased screen for candidate mediators, we identify the dendrite-specific high-molecular-weight microtubule-associated protein 2 (MAP2) as a JNK substrate in the brain. We subsequently show that MAP2 is phosphorylated by JNK in intact cells and that MAP2 proline-rich domain phosphorylation is decreased in JNK1-/- brain. We developed compartment-targeted JNK inhibitors to define whether a functional relationship exists between the physiologically active, cytosolic pool of JNK and dendritic architecture. Using these, we demonstrate that cytosolic, but not nuclear, JNK determines dendritic length and arbor complexity in cultured neurons. Moreover, we confirm that MAP2-dependent process elongation is enhanced after activation of JNK. Using JNK1-/- neurons, we reveal a dominant role for JNK1 over ERK in regulating dendritic arborization, whereas ERK only regulates dendrite shape under conditions in which JNK activity is low (JNK1-/- neurons). These results reveal a novel antagonism between JNK and ERK, potentially providing a mechanism for fine-tuning the dendritic arbor. Together, these data suggest that JNK phosphorylation of MAP2 plays an important role in defining dendritic architecture in the brain.

Published
2005
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46. c-Jun N-Terminal Kinase Phosphorylation of MARCKSL1 Determines Actin Stability and Migration in Neurons and in Cancer Cells

Author

Björkblom, Benny, primary, Padzik, Artur, additional, Mohammad, Hasan, additional, Westerlund, Nina, additional, Komulainen, Emilia, additional, Hollos, Patrik, additional, Parviainen, Lotta, additional, Papageorgiou, Anastassios C., additional, Iljin, Kristiina, additional, Kallioniemi, Olli, additional, Kallajoki, Markku, additional, Courtney, Michael J., additional, Mågård, Mats, additional, James, Peter, additional, and Coffey, Eleanor T., additional

Published
2012
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48. Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate

Author

Westerlund, Nina, primary, Zdrojewska, Justyna, additional, Padzik, Artur, additional, Komulainen, Emilia, additional, Björkblom, Benny, additional, Rannikko, Emmy, additional, Tararuk, Tanya, additional, Garcia-Frigola, Cristina, additional, Sandholm, Jouko, additional, Nguyen, Laurent, additional, Kallunki, Tuula, additional, Courtney, Michael J, additional, and Coffey, Eleanor T, additional

Published
2011
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50. Tasks, talk and teaching : task-based language learning and the negotiation of meaning in oral interaction

Author

Courtney, Michael J. and Courtney, Michael J.

Abstract

Undergraduates in Hong Kong universities are taught in an English-medium environment but come from an educational background where classroom opportunities to practise speaking in English are limited. Stimulating and motivating oral materials are an essential tool to help students to practise in the classroom in meaningful ways. Interactive peer-group oral tasks not only provide a practical basis for oral development within a language syllabus, but they can also promote the essential skill of critical thinking. A theoretical justification for their use can be derived from second language acquisition research but the best justification is from learners themselves. This report explores the key theoretical issues surrounding the use of such pedagogy. The main issue is so-called “negotiated meaning”, specifically in relation to such classroom tasks. However, exploration of this theoretical area inevitably takes us into a general discussion of the role of interaction in discourse analysis – particularly in relation to developments in the fairly recent field of conversation analysis. Previous studies have made strong claims in relation to the potential of interactive communication tasks for language acquisition. However, researchers have based their claims on small samples and limited descriptions of task design and task performance. The present study used a much larger intact sample and a more detailed and inclusive task taxonomy. The first part of the investigation establishes a method for classifying the design of commonly used oral interactive tasks (the input). A method is developed to quantify the performance (the output) of such tasks statistically. Finally, the central performance activity of negotiated meaning is discussed in some detail in relation to task participant interaction and the theoretical question of language acquisition. The investigation concludes that statistically significant links between input and output were evident, thereby offering a principle

Published
2001

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