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453 results on '"Court W"'

3. Refractory CRPS pain treated with psilocybin: A case report

Author

David S. Jevotovsky, Harman Chopra, Court Wing, Carlton J. Spotswood, and Joel Castellanos

Subjects
chronic pain, complex regional pain syndrome, psilocybin, psychedelics, Medicine, Medicine (General), R5-920
Abstract

Key Clinical Message Psilocybin shows promise as a treatment for CRPS, offering significant pain relief and functional improvement in a patient with refractory symptoms. This case highlights the need for further research into psilocybin's efficacy and optimal dosing for chronic pain management.

Published
2024
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8. Integration of multiple platforms for the analysis of multifluorescent marking technology applied to pediatric GBM and dipg

Author

Pericoli, G., Petrini, S., Giorda, E., Ferretti, R., Ajmone-Cat, M. A., Court, W., Conti, L. A., De Simone, R., Bencivenga, P., Palma, A., Di Giannatale, A., Jones, C., Carai, A., Mastronuzzi, A., de Billy, E., Locatelli, Franco, Vinci, M., Locatelli F. (ORCID:0000-0002-7976-3654), Pericoli, G., Petrini, S., Giorda, E., Ferretti, R., Ajmone-Cat, M. A., Court, W., Conti, L. A., De Simone, R., Bencivenga, P., Palma, A., Di Giannatale, A., Jones, C., Carai, A., Mastronuzzi, A., de Billy, E., Locatelli, Franco, Vinci, M., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

The intratumor heterogeneity represents one of the most difficult challenges for the development of effective therapies to treat pediatric glioblastoma (pGBM) and diffuse intrinsic pontine glioma (DIPG). These brain tumors are composed of heterogeneous cell subpopulations that coexist and cooperate to build a functional network responsible for their aggressive phenotype. Understanding the cellular and molecular mechanisms sustaining such network will be crucial for the identification of new therapeutic strategies. To study more in-depth these mechanisms, we sought to apply the Multifluorescent Marking Technology. We generated multifluorescent pGBM and DIPG bulk cell lines randomly expressing six different fluorescent proteins and from which we derived stable optical barcoded single cell-derived clones. In this study, we focused on the application of the Multifluorescent Marking Technology in 2D and 3D in vitro/ex vivo culture systems. We discuss how we integrated different multimodal fluorescence analysis platforms, identifying their strengths and limitations, to establish the tools that will enable further studies on the intratumor heterogeneity and interclonal interactions in pGBM and DIPG.

Published
2020

19. p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis

Author

Hw, Stürzbecher, Maimets T, Peter Chumakov, Brain R, Addison C, Simanis V, Rudge K, Philp R, Grimaldi M, and Court W

Subjects
DNA Replication, Oncogene Proteins, Cell Cycle, Molecular Sequence Data, Haplorhini, Phosphoproteins, Transfection, Precipitin Tests, Cell Line, CDC2 Protein Kinase, Animals, Humans, Amino Acid Sequence, Phosphorylation, Tumor Suppressor Protein p53, Protein Kinases, HeLa Cells
Abstract

The p53 gene product has been implicated in both human and animal tumorigenesis. p53 complexes with the transforming proteins encoded by several different DNA tumour viruses. We demonstrate that human p53 is phosphorylated by the mammalian p34cdc2 kinase in vitro and coprecipitates with p34cdc2 in vivo. Our observations suggest that phosphorylation of p53 by p34cdc2 kinase may regulate the known activities of p53 in the initiation steps of DNA replication in mammalian cells.

Published
1990

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